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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALB Gene

protein-coding   GIFtS: 69
GCID: GC04P074259

albumin
 Explore 531 diseases affiliated with
ALB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ALB    

Aliases
for ALB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Albumin1     Albumin (AA 34)2
PRO08832     Cell Growth Inhibiting Protein 422
PRO09032     Growth-Inhibiting Protein 202
PRO13412     Serum Albumin2
Albumin (32 AA)2     

External Ids:    HGNC: 3991   Entrez Gene: 2132   Ensembl: ENSG000001636317   OMIM: 1036005   UniProtKB: P027683   

Export aliases for ALB gene to outside databases

Previous GC identifers: GC04P074509 GC04P074670 GC04P074736 GC04P074635 GC04P070083


Summaries
for ALB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ALB:
Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions
primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing
extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. Albumin is
synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein
is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to
produce the secreted albumin. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty
acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood.
Major zinc transporter in plasma, typically binds about 80% of all plasma zinc

Gene Wiki entry for ALB (Serum albumin)


Genomic Views
for ALB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALB gene promoter:
         STAT5B   TBP   STAT1   STAT4   STAT1beta   STAT5A   STAT1alpha   C/EBPalpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 15): ALB promoter sequence
   Search SABiosciences Chromatin IP Primers for ALB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

ALB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALB gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074259:  view genomic region     (about GC identifiers)

Start:
 74,262,831 bp from pter      End:
 74,287,129 bp from pter
Size:
 24,299 bases      Orientation:
 plus strand

Proteins
for ALB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768 (See protein sequence)
Recommended Name: Serum albumin precursor  
Size: 609 amino acids; 69367 Da
Subcellular location: Secreted
Caution: A peptide arising from positions 166 to 174 was originally (PubMed:3087352 and PubMed:2437111) termed
neurotensin-related peptide (NRP) or kinetensin and was thought to regulate fat digestion, lipid absorption, and blood
flow
Sequence caution: Sequence=AAF22034.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAF69644.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAG35503.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
6/72 PDB 3D structures from and Proteopedia for ALB (see all 72):
1AO6 (3D)        1BJ5 (3D)        1BKE (3D)        1BM0 (3D)        1E78 (3D)        1E7A (3D)    
Secondary accessions: O95574 P04277 Q13140 Q645G4 Q68DN5 Q6UXK4 Q86YG0 Q9P157 Q9P1I7 Q9UHS3 Q9UJZ0
Alternative splicing: 2 isoforms:  P02768-1   P02768-2   

Explore the universe of human proteins at neXtProt for ALB: NX_P02768

Post-translational modifications:

  • Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601
    • to Cys-6061
  • Glycated in diabetic patients1
  • Phosphorylation sites are present in the extracellular medium1
  • Acetylated on Lys-223 by acetylsalicylic acid1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P02768

    • ALB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000468.1  
    ENSEMBL proteins: 
     ENSP00000392541   ENSP00000295897   ENSP00000401820   ENSP00000423727   ENSP00000421027  
     ENSP00000422784   ENSP00000384695   ENSP00000426179  
    Reactome Protein details: P02768
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for ALB
    OriGene Purified Protein: ALB
    OriGene Protein Over-expression Lysate: ALB
    OriGene Custom Protein Services for ALB 
    GenScript Custom Purified and Recombinant Proteins Services for ALB
    Novus Biologicals ALB Proteins
    Novus Biologicals ALB Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for ALB
    Uscn Proteins for ALB

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IDA19996109
    GO:0005737cytoplasm ----
    GO:0031093platelet alpha granule lumen TAS--


    ALB for ontologies           About GeneDecksing



    ALB Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ALB  (albumin)
    OriGene Antibodies (see all 5): ALB
    OriGene Custom Antibody Services for ALB 
    GenScript Superior Antibodies for ALB
    Novus Biologicals ALB Antibodies
    Abcam antibodies for ALB 
    Uscn Antibodies for ALB
    ThermoFisher Antibody for ALB

    Assay Products for ALB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ALB
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ALB

    Protein Domains /
    Families
    for ALB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ALB for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR020858 Serum_albumin-like
     IPR000264 Serum_albumin
     IPR014760 Serum_albumin_N
     IPR020857 Serum_albumin_CS
     IPR021177 Serum_albumin_subgr

    Graphical View of Domain Structure for InterPro Entry P02768

    ProtoNet protein and cluster: P02768

    1 Blocks protein family: IPB000264 Serum albumin family

    UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
    Similarity: Belongs to the ALB/AFP/VDB family
    Similarity: Contains 3 albumin domains


    Function
    for ALB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
    Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty
    acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood.
    Major zinc transporter in plasma, typically binds about 80% of all plasma zinc

         Genatlas biochemistry entry for ALB:
    albumin,putative down-regulated c-Myc target gene,

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ALB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALB
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ALB
    SwitchGear 3'UTR luciferase reporter plasmid: ALB 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALB (see all 4)
    OriGene shRNA RFP: ALB
    OriGene siRNA: ALB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ALB

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALB (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALB (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ALB (NM_000477)
    Sino Biological Human cDNA Clone for ALB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALB 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ALB
    Search LifeMap BioReagents cell lines for ALB

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALB

    Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA16405401
    GO:0005504fatty acid binding NAS9731778
    GO:0005507copper ion binding NAS14726550
    GO:0005515protein binding IPI16099937
    GO:0008144drug binding NAS10940303


    ALB for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for ALB: Albtm1Lex Afp/AlbAfp/tm1.1Brts
         6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Alb):
     digestive/alimentary  homeostasis/metabolism  liver/biliary system  mortality/aging  normal 
     renal/urinary system 

    ALB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ALB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lipoprotein metabolism
    		Lipoprotein metabolism1.00
    		Lipid digestion, mobilization, and transport0.56
    		HDL-mediated lipid transport0.57
    2Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43
    3Platelet degranulation
    		Platelet degranulation 1.00
    		Response to elevated platelet cytosolic Ca2+0.94
    4Transport of organic anions
    		Transport of organic anions1.00
    		Transport of vitamins, nucleosides, and related molecules0.35
    5SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for ALB
        Selected targets of HNF1
    Selected targets of C/EBPalpha


    2 BioSystems Pathways for ALB 
        Selenium Pathway
    FOXA2 and FOXA3 transcription factor networks

    5/17        Reactome Pathways for ALB (see all 17)
        Metabolism
    Recycling of bile acids and salts
    Response to elevated platelet cytosolic Ca2+
    Transmembrane transport of small molecules
    SLC-mediated transmembrane transport



    ALB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    227/248 Interacting proteins for ALB (P027682, 3 ENSP000002958974) via UniProtKB, MINT, STRING, and/or I2D (see all 248) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IMMTQ168912, 3, ENSP000003872624MINT-8258723 I2D: score=2 STRING: ENSP00000387262
    PFDN1O609252, 3MINT-8265687 I2D: score=2 
    TK1P041832, 3MINT-8272905 I2D: score=2 
    LUC7L2Q9Y3833, ENSP000003470054I2D: score=4 STRING: ENSP00000347005
    C7orf55-LUC7L2Q9Y3833I2D: score=4 
    DMWDQ090193, ENSP000002702234I2D: score=2 STRING: ENSP00000270223
    F7P087093, ENSP000003647314I2D: score=2 STRING: ENSP00000364731
    FCGRTP558993, ENSP000002214664I2D: score=2 STRING: ENSP00000221466
    RYR2Q927363, ENSP000003555334I2D: score=2 STRING: ENSP00000355533
    UIMC1Q96RL13, ENSP000003664344I2D: score=2 STRING: ENSP00000366434
    USP37Q86T823, ENSP000002583994I2D: score=2 STRING: ENSP00000258399
    YWHAGP619813, ENSP000003063304I2D: score=2 STRING: ENSP00000306330
    ADRA1BP353683, ENSP000003066624I2D: score=1 STRING: ENSP00000306662
    AGAP209333, ENSP000002645954I2D: score=1 STRING: ENSP00000264595
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    APOC1P026543, ENSP000002524914I2D: score=1 STRING: ENSP00000252491
    ATMQ133153, ENSP000002786164I2D: score=1 STRING: ENSP00000278616
    BBC3Q9BXH13, ENSP000004045034I2D: score=1 STRING: ENSP00000404503
    CACNA1IQ9P0X43, ENSP000003850194I2D: score=1 STRING: ENSP00000385019
    CAMTA1Q9Y6Y13, ENSP000003065224I2D: score=1 STRING: ENSP00000306522
    CDC45O754193, ENSP000002632014I2D: score=1 STRING: ENSP00000263201
    CDCP1Q9H5V83, ENSP000002961294I2D: score=1 STRING: ENSP00000296129
    CFDP007463, ENSP000003321394I2D: score=1 STRING: ENSP00000332139
    CLCA2Q9UQC93, ENSP000003595964I2D: score=1 STRING: ENSP00000359596
    CST3P010343, ENSP000003661244I2D: score=1 STRING: ENSP00000366124
    CTSL1P077113, ENSP000003453444I2D: score=1 STRING: ENSP00000345344
    DCCP431463, ENSP000003891404I2D: score=1 STRING: ENSP00000389140
    DCDP816053, ENSP000002933714I2D: score=1 STRING: ENSP00000293371
    DERL1Q9BUN83, ENSP000002595124I2D: score=1 STRING: ENSP00000259512
    DGKGP496193, ENSP000002650224I2D: score=1 STRING: ENSP00000265022
    EXOC6Q8TAG93, ENSP000002607624I2D: score=1 STRING: ENSP00000260762
    F2P007343, ENSP000003085414I2D: score=1 STRING: ENSP00000308541
    FGAP026713, ENSP000003063614I2D: score=1 STRING: ENSP00000306361
    FN1P027513, ENSP000003468394I2D: score=1 STRING: ENSP00000346839
    GCN1L1Q926163, ENSP000003006484I2D: score=1 STRING: ENSP00000300648
    GJC2Q5T4423, ENSP000003556754I2D: score=1 STRING: ENSP00000355675
    GSNP063963, ENSP000003629244I2D: score=1 STRING: ENSP00000362924
    HNF1AP208233, ENSP000002575554I2D: score=1 STRING: ENSP00000257555
    HPP007383, ENSP000003481704I2D: score=1 STRING: ENSP00000348170
    HPXP027903, ENSP000002659834I2D: score=1 STRING: ENSP00000265983
    ITGA2P173013, ENSP000002965854I2D: score=1 STRING: ENSP00000296585
    ITGB5P180843, ENSP000002961814I2D: score=1 STRING: ENSP00000296181
    ITIH1P198273, ENSP000002732834I2D: score=1 STRING: ENSP00000273283
    KRT14P025333, ENSP000001675864I2D: score=1 STRING: ENSP00000167586
    KRT6AP025383, ENSP000003693174I2D: score=1 STRING: ENSP00000369317
    LATO435613, ENSP000003541194I2D: score=1 STRING: ENSP00000354119
    LRP2P981643, ENSP000002638164I2D: score=1 STRING: ENSP00000263816
    MYL4P128293, ENSP000003470554I2D: score=1 STRING: ENSP00000347055
    NCOA3Q9Y6Q93, ENSP000003610664I2D: score=1 STRING: ENSP00000361066
    NPHS1O605003, ENSP000003681904I2D: score=1 STRING: ENSP00000368190
    OR2T6Q8NHC83, ENSP000003479654I2D: score=1 STRING: ENSP00000347965
    OR3A2P478933, ENSP000003861804I2D: score=1 STRING: ENSP00000386180
    OR8D2Q9GZM63, ENSP000003500224I2D: score=1 STRING: ENSP00000350022
    ORM1P027633, ENSP000002593964I2D: score=1 STRING: ENSP00000259396
    PALB2Q86YC23, ENSP000002615844I2D: score=1 STRING: ENSP00000261584
    PCDH1Q081743, ENSP000002870084I2D: score=1 STRING: ENSP00000287008
    PDZRN4Q6ZMN73, ENSP000002989194I2D: score=1 STRING: ENSP00000298919
    PLA2G4FQ68DD23, ENSP000003718334I2D: score=1 STRING: ENSP00000371833
    PLAG1Q6DJT93, ENSP000003255464I2D: score=1 STRING: ENSP00000325546
    PRB3Q041183, ENSP000003712644I2D: score=1 STRING: ENSP00000371264
    SACSQ9NZJ43, ENSP000003717294I2D: score=1 STRING: ENSP00000371729
    SERPING1P051553, ENSP000002784074I2D: score=1 STRING: ENSP00000278407
    SLA2Q9H6Q33, ENSP000002628664I2D: score=1 STRING: ENSP00000262866
    SORBS3O605043, ENSP000002401234I2D: score=1 STRING: ENSP00000240123
    SRGNP101243, ENSP000002424654I2D: score=1 STRING: ENSP00000242465
    THRAP3Q9Y2W13, ENSP000003466344I2D: score=1 STRING: ENSP00000346634
    TRAPPC11Q7Z3923, ENSP000003353714I2D: score=1 STRING: ENSP00000335371
    TTPALQ9BTX73, ENSP000002626054I2D: score=1 STRING: ENSP00000262605
    TTRP027663, ENSP000002370144I2D: score=1 STRING: ENSP00000237014
    ZNF232Q9UNY53, ENSP000002500764I2D: score=1 STRING: ENSP00000250076
    IGHA1P018763, ENSP000003749894I2D: score=1 STRING: ENSP00000374989
    IGKCP018343, ENSP000003747774I2D: score=1 STRING: ENSP00000374777
    APOEP026493, ENSP000002524864I2D: score=2 STRING: ENSP00000252486
    AMBPP027603, ENSP000002651324I2D: score=2 STRING: ENSP00000265132
    CRYAAP024893, ENSP000002915544I2D: score=1 STRING: ENSP00000291554
    CUBNO604943, ENSP000003670644I2D: score=2 STRING: ENSP00000367064
    PON1P271693, ENSP000002223814I2D: score=1 STRING: ENSP00000222381
    RBP4P027533, ENSP000003605194I2D: score=1 STRING: ENSP00000360519
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=1 STRING: ENSP00000268607
    AHSGP027653, ENSP000003938874I2D: score=1 STRING: ENSP00000393887
    AP1M1Q9BXS53, ENSP000003889964I2D: score=1 STRING: ENSP00000388996
    AP4E1Q9UPM83, ENSP000002618424I2D: score=1 STRING: ENSP00000261842
    APOA2P026523, ENSP000003569694I2D: score=1 STRING: ENSP00000356969
    APOA4P067273, ENSP000003504254I2D: score=1 STRING: ENSP00000350425
    APOC3P026563, ENSP000002276674I2D: score=1 STRING: ENSP00000227667
    C4AP0C0L43, ENSP000003966884I2D: score=1 STRING: ENSP00000396688
    CABLES1Q8TDN43, ENSP000002569254I2D: score=1 STRING: ENSP00000256925
    CEP44Q9C0F13, ENSP000003894274I2D: score=1 STRING: ENSP00000389427
    CFBP007513, ENSP000004165614I2D: score=1 STRING: ENSP00000416561
    CFHP086033, ENSP000003563994I2D: score=1 STRING: ENSP00000356399
    CHKBQ9Y2593, ENSP000003844004I2D: score=1 STRING: ENSP00000384400
    CNOT1A5YKK63, ENSP000003209494STRING: ENSP00000320949 I2D: score=1 
    CRB1P822793, ENSP000003563704I2D: score=1 STRING: ENSP00000356370
    CROTQ9UKG93, ENSP000004135754I2D: score=1 STRING: ENSP00000413575
    CTAGE5O153203, ENSP000002800834I2D: score=1 STRING: ENSP00000280083
    DDB1Q165313, ENSP000003017644I2D: score=1 STRING: ENSP00000301764
    DICER1Q9UPY33, ENSP000003437454I2D: score=1 STRING: ENSP00000343745
    DMDP115323, ENSP000003549234I2D: score=1 STRING: ENSP00000354923
    ETF1P624953, ENSP000003537414I2D: score=1 STRING: ENSP00000353741
    GFAPP141363, ENSP000002534084I2D: score=1 STRING: ENSP00000253408
    GRAP2O757913, ENSP000003391864I2D: score=1 STRING: ENSP00000339186
    IGDCC4Q8TDY83, ENSP000003196234I2D: score=1 STRING: ENSP00000319623
    IGHG1P018573, ENSP000003749904I2D: score=1 STRING: ENSP00000374990
    IGHG2P018593, ENSP000003749874I2D: score=1 STRING: ENSP00000374987
    JARID2Q928333, ENSP000003412804I2D: score=1 STRING: ENSP00000341280
    KCNMA1Q127913, ENSP000002866274I2D: score=2 STRING: ENSP00000286627
    KIAA0232Q926283, ENSP000003039284I2D: score=1 STRING: ENSP00000303928
    KIAA1551Q9HCM13, ENSP000003103384I2D: score=1 STRING: ENSP00000310338
    KLK3P072883, ENSP000003141514I2D: score=2 STRING: ENSP00000314151
    KRT1P042643, ENSP000002522444I2D: score=1 STRING: ENSP00000252244
    KRT10P136453, ENSP000002695764I2D: score=1 STRING: ENSP00000269576
    KRT13P136463, ENSP000002466354I2D: score=1 STRING: ENSP00000246635
    KRT16P087793, ENSP000003016534I2D: score=1 STRING: ENSP00000301653
    KRT5P136473, ENSP000002522424I2D: score=1 STRING: ENSP00000252242
    KRT6BP042593, ENSP000002522524I2D: score=1 STRING: ENSP00000252252
    KRT9P355273, ENSP000002466624I2D: score=1 STRING: ENSP00000246662
    LDB3O751123, ENSP000003552964I2D: score=1 STRING: ENSP00000355296
    MYLK3Q32MK03, ENSP000003782884I2D: score=1 STRING: ENSP00000378288
    OBSL1O751473, ENSP000003856364I2D: score=1 STRING: ENSP00000385636
    PDE4BQ073433, ENSP000003321164I2D: score=1 STRING: ENSP00000332116
    PEG3Q9GZU23, ENSP000003265814I2D: score=1 STRING: ENSP00000326581
    PF4V1P107203, ENSP000002265244I2D: score=1 STRING: ENSP00000226524
    PPBPP027753, ENSP000002960284I2D: score=1 STRING: ENSP00000296028
    PRSS1P074773, ENSP000003087204I2D: score=1 STRING: ENSP00000308720
    PRSS3P350303, ENSP000003542804I2D: score=1 STRING: ENSP00000354280
    QTRTD1Q9H9743, ENSP000002812734I2D: score=1 STRING: ENSP00000281273
    RANBP2P497923, ENSP000002831954I2D: score=1 STRING: ENSP00000283195
    RANBP3Q9H6Z43, ENSP000003414834I2D: score=1 STRING: ENSP00000341483
    RLFQ131293, ENSP000003618574I2D: score=1 STRING: ENSP00000361857
    SCAF1Q9H7N43, ENSP000003537694I2D: score=1 STRING: ENSP00000353769
    SCN5AQ145243, ENSP000003289684I2D: score=1 STRING: ENSP00000328968
    SETXQ7Z3333, ENSP000002241404I2D: score=1 STRING: ENSP00000224140
    SH3BP5O602393, ENSP000003733014I2D: score=1 STRING: ENSP00000373301
    SLC25A13Q9UJS03, ENSP000002656314I2D: score=1 STRING: ENSP00000265631
    SLC9A8Q9Y2E83, ENSP000003549664I2D: score=1 STRING: ENSP00000354966
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    SPASTQ9UBP03, ENSP000003208854I2D: score=1 STRING: ENSP00000320885
    SPATA31A7Q8IWB43, ENSP000003471534I2D: score=1 STRING: ENSP00000347153
    ST13P505023, ENSP000002162184I2D: score=2 STRING: ENSP00000216218
    TFP027873, ENSP000002649984I2D: score=1 STRING: ENSP00000264998
    TIAM1Q130093, ENSP000002868274I2D: score=1 STRING: ENSP00000286827
    TLN2Q9Y4G63, ENSP000003034764I2D: score=1 STRING: ENSP00000303476
    TSC22D1Q157143, ENSP000003974354I2D: score=1 STRING: ENSP00000397435
    ZNF292O602813, ENSP000003585904I2D: score=1 STRING: ENSP00000358590
    TFRCP027862MINT-8413175 MINT-8412660
    GABARAPO951663I2D: score=2 
    GRB2P629933I2D: score=2 
    NR5A2O004823I2D: score=2 
    PLCB1Q9NQ663I2D: score=2 
    YWHAEP622583I2D: score=2 
    ACTA1P681333I2D: score=1 
    ALDH16A1Q8IZ833I2D: score=1 
    AMPD3Q014323I2D: score=1 
    APOC2P026553I2D: score=1 
    ATG10Q9H0Y03I2D: score=1 
    ATG12O948173I2D: score=1 
    ATG4BQ9Y4P13I2D: score=1 
    ATG5Q9H1Y03I2D: score=1 
    C12orf44Q9BSB43I2D: score=1 
    DDIT3P356383I2D: score=1 
    GABARAPL1Q9H0R83I2D: score=1 
    GABBR1Q9UBS53I2D: score=1 
    GOSR1O952493I2D: score=1 
    IL7RP168713I2D: score=1 
    KBTBD7Q8WVZ93I2D: score=1 
    MAP1LC3AQ9H4923I2D: score=1 
    MLST8Q9BVC43I2D: score=1 
    NR3C1P041503I2D: score=1 
    NSMAFQ926363I2D: score=1 
    PCED1BQ96HM73I2D: score=1 
    PHC3Q8NDX53I2D: score=1 
    PRKAB2O437413I2D: score=1 
    PSMA3P257883I2D: score=1 
    PSMD4P550363I2D: score=1 
    SETQ011053I2D: score=1 
    SH3GLB2Q9NR463I2D: score=1 
    SLC1A5Q157583I2D: score=1 
    TTNQ8WZ423I2D: score=1 
    ACADVLP497482MINT-6549314
    CDK1P064932MINT-6549314
    DENRO435832MINT-6549314
    EEF2KO004182MINT-6549314
    EIF4A3P389192MINT-6549314
    METAP2P505792MINT-6549314
    PA2G4Q9UQ802MINT-6549314
    A2MENSP000003239294STRING: ENSP00000323929
    ABCB11ENSP000002638174STRING: ENSP00000263817
    ABCC3ENSP000002852384STRING: ENSP00000285238
    ACTN1ENSP000003779414STRING: ENSP00000377941
    ACTN2ENSP000003555374STRING: ENSP00000355537
    ACTN4ENSP000002526994STRING: ENSP00000252699
    ALDOAENSP000003369274STRING: ENSP00000336927
    APPENSP000002849814STRING: ENSP00000284981
    CLUENSP000003151304STRING: ENSP00000315130
    EGFENSP000002651714STRING: ENSP00000265171
    F13A1ENSP000002648704STRING: ENSP00000264870
    F5ENSP000003567714STRING: ENSP00000356771
    F8ENSP000003533934STRING: ENSP00000353393
    FABP6ENSP000003775494STRING: ENSP00000377549
    FIGFENSP000002979044STRING: ENSP00000297904
    FOXA1ENSP000002504484STRING: ENSP00000250448
    FOXA3ENSP000003040044STRING: ENSP00000304004
    GAS6ENSP000003318314STRING: ENSP00000331831
    KNG1ENSP000002650234STRING: ENSP00000265023
    LCATENSP000002640054STRING: ENSP00000264005
    MMRN1ENSP000002647904STRING: ENSP00000264790
    PF4ENSP000002960294STRING: ENSP00000296029
    PLGENSP000003089384STRING: ENSP00000308938
    SERPINA1ENSP000003480684STRING: ENSP00000348068
    SERPINE1ENSP000002230954STRING: ENSP00000223095
    SERPINF2ENSP000003218534STRING: ENSP00000321853
    SLC10A1ENSP000002165404STRING: ENSP00000216540
    SLC10A2ENSP000002453124STRING: ENSP00000245312
    SLC27A5ENSP000002630934STRING: ENSP00000263093
    SLCO1A2ENSP000003059744STRING: ENSP00000305974
    SLCO1B1ENSP000002569584STRING: ENSP00000256958
    SLCO1B3ENSP000002611964STRING: ENSP00000261196
    SPARCENSP000002310614STRING: ENSP00000231061
    TGFB1ENSP000002219304STRING: ENSP00000221930
    TGFB2ENSP000003558964STRING: ENSP00000355896
    TGFB3ENSP000002386824STRING: ENSP00000238682
    TIMP1ENSP000002183884STRING: ENSP00000218388
    VEGFCENSP000002801934STRING: ENSP00000280193
    PPP2R2BENSP000003365914STRING: ENSP00000336591
    FBXO25ENSP000002763264STRING: ENSP00000276326
    IQCB1ENSP000003115054STRING: ENSP00000311505
    AMIGO2ENSP000003208484STRING: ENSP00000320848
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0006629lipid metabolic process TAS--
    GO:0006810transport TAS12617161
    GO:0006950response to stress ----
    GO:0007584response to nutrient IEA--


    ALB for ontologies           About GeneDecksing



    Drugs & Compounds
    for ALB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALB

    10 HMDB Compounds for ALB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Bilirubin(4Z,15Z)-Bilirubin IXa (see all 17)635-65-418498776
    BismuthBi (see all 2)7440-69-9--
    ChlorpheniramineChlor-trimeton (see all 8)113-92-8--
    Estrone(+)-Estrone (see all 7)53-16-7--
    Estrone sulfateConestoral (see all 12)481-97-0--
    Ibuprofenalpha-(4-Isobutylphenyl)propionate (see all 9)15687-27-1--
    Liothyronine3,3',5-Triiodo-L-thyronine (see all 20)6893-02-3--
    Pyridoxine2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine (see all 16)65-23-6--
    Sodium lauryl sulfateAdeka Hope LS 35 (see all 243)151-21-3--
    Testosterone(+)-testosterone (see all 86)58-22-0--

    10/107 DrugBank Compounds for ALB (see all 107)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sodium lauryl sulfateDodecyl alcohol, hydrogen sulfate, sodium salt (see all 27)151-21-3carrierbinder16457837 16085141 16256620 16256532 11752352 16379295
    CefoperazoneCefoperazono [inn-spanish] (see all 2)62893-19-0carrierother/unknown2311445 2496656 3339510 16379298 8950041
    PhenprocoumonFenprocumone [DCIT] (see all 5)435-97-2carrier--1205658 1642965 4762907 2751413 12543492
    Auranofin-- 34031-32-8carrier--11666224 7925457 2403377 3655788
    CaptoprilCaptoprilum [INN-Latin] (see all 3)62571-86-2carrierother/unknown16469467 8216349 9040098 15093593
    Diflunisal-- 22494-42-4carrier--17132209 11673972 7371361 2751413
    DigitoxinDigitoksin (see all 3)71-63-6carrier--11678517 10774625 10604823 10202961
    Ethacrynic acidEtacrinic acid (see all 6)58-54-8carrier--9275312 3714803 9863950 2792351
    Fospropofol-- 258516-87-9carrier--16032968 15791110 15449957 17311911
    Gadobenate Dimeglumine-- 113662-23-0carrierbinder9055236 16118549 11752352 9406019

    10/140 Novoseek chemical compound relationships for ALB gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 90.6 3964 10727680 (8), 8831085 (7), 9080259 (7), 17405790 (7) (see all 99)
    fibrinogen 83.7 1545 16703327 (7), 9610611 (7), 11422756 (7), 12969171 (7) (see all 99)
    cholesterol 79.9 2000 15082432 (7), 8524502 (6), 18563300 (6), 17279492 (5) (see all 99)
    rhsa 78.5 72 9167443 (2), 10502345 (2), 18199895 (2), 9688461 (2) (see all 38)
    dansylsarcosine 78.2 30 1382424 (6), 9430764 (3), 8720306 (2), 1706921 (2) (see all 16)
    urea 77.8 659 8366899 (5), 8573919 (4), 17361319 (4), 10666933 (4) (see all 99)
    uric acid 76.4 495 10910618 (5), 10898045 (4), 18442624 (4), 16554340 (3) (see all 99)
    hydroxyethyl starch 76.4 487 10703679 (8), 11515893 (7), 9261899 (6), 10361869 (6) (see all 99)
    glucose 73.8 1576 19349048 (6), 9103700 (6), 8575721 (6), 16920285 (5) (see all 99)
    fructosamine 71.2 212 10326628 (7), 1597333 (5), 8893144 (5), 8502341 (5) (see all 95)

    Search CenterWatch for drugs/clinical trials and news about ALB / ALBU 

    Transcripts
    for ALB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ALB gene: 
    NM_000477.5  

    Unigene Clusters for ALB:

    Albumin
    Hs.418167  [show with all ESTs], Hs.592379  [show with all ESTs]
    Unigene Representative Sequences: NM_000477, BX436222
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441319 ENST00000295897(uc003hgs.4 uc011cbe.2 uc003hgw.4 uc011cbf.2)
    ENST00000510166 ENST00000515133 ENST00000415165 ENST00000514786 ENST00000476441
    ENST00000503124 ENST00000509063 ENST00000401494 ENST00000505649 ENST00000511370
    ENST00000507673 ENST00000484992 ENST00000504043 ENST00000486939 ENST00000508932
    ENST00000495173

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ALB
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALB
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ALB
    SwitchGear 3'UTR luciferase reporter plasmid: ALB 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALB (see all 4)
    OriGene shRNA RFP: ALB
    OriGene siRNA: ALB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALB
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALB (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALB (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ALB (NM_000477)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALB 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALB

    Additional cDNA sequence: X51365.1 

    24/209 DOTS entries (see all 209):

    DT.100864734  DT.98132054  DT.95377482  DT.100746389  DT.87011119  DT.100861910  DT.100746447  DT.100746541 
    DT.91816166  DT.95377906  DT.95376610  DT.100746432  DT.95376706  DT.100844172  DT.95376678  DT.100861974 
    DT.100746557  DT.100746613  DT.95376631  DT.91998425  DT.92056056  DT.98132061  DT.100746529  DT.95376639 

    24/3197 AceView cDNA sequences (see all 3197):

    CR597211 AA333868 CB154310 AI338727 BX346129 AI065100 AU121366 AI110642 
    R29144 CR599721 BC036003 BX448686 T40025 AL557745 AA343603 R28850 
    CB116624 T40773 T39951 AL531680 BX462983 AL531846 BX400101 AL558090 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ALB (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a ·
    SP1:                                                              -                             -                       -                                       
    SP2:                                                  -     -     -     -     -     -     -     -     -     -           -                                       
    SP3:                    -     -     -     -     -     -     -     -     -     -                 -                       -                                       
    SP4:                          -     -     -     -     -     -     -     -     -     -           -                       -                                       
    SP5:                                      -     -     -     -     -     -                       -                                                               

    ExUns: 14b ^ 15 ^ 16a · 16b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ALB

    Expression
    for ALB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAATAAGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ALB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeVentral Foregut EndodermHepatic Endoderm CellsLiver
    LiverHepatic DiverticulumHepatic Diverticulum CellsLiver
    LiverLiver BudHepatoblastsLiver
    LiverLiver LobuleHepatocytesLiver
    LiverLiver LobuleMature HepatocytesLiver
    LiverIntrahepatic Biliary TreeOval CellsLiver
    LiverLiver LobuleFetal HepatocytesLiver
    AdiposeBody Subcutaneous White AdiposeAdipose
    HeartRight VentricleHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/12 LifeMap Cells (see all 12) 
    NameCategory
    Hepatocyte-like cells (Generation of hepato...)
    Hepatocyte-like cells (Mouse embryonic stem...)
    Endocrine progenitors (Generation of pancre...)
    Hepatocyte-like cells (Functional hepatocyt...)
    Immature hepatocytes (Functional, immature...)
    Immature hepatocyte-like cells (Hepatocyte-like cell...)
    Early hepatocyte like-cells (Hepatocyte-like cell...)
    Chondrocyte-like cells (Direct differentiati...)Bone, Cartilage
    Primitive Streak Mesendoderm cells (Direct differentiati...)
    Mesoderm-like cells (Direct differentiati...)Mesoderm

    See ALB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALB

    SOURCE GeneReport for Unigene clusters: Hs.418167 Hs.592379

    UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
    Tissue specificity: Plasma

        SABiosciences Expression via Pathway-Focused PCR Arrays including ALB: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Oxidative Stress in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALB
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALB

    Orthologs
    for ALB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ALB gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ALB1 albumin 60.37(n)
    47.95(a)    		   396197  NM_205261.1  NP_990592.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii gc6
    		 group-specific component (vitamin D binding protei...
    		 20(a)
    		 1 → many
    		 5(47282879-47303096)


    ENSEMBL Gene Tree for ALB (if available)
    TreeFam Gene Tree for ALB (if available) 

    Paralogs
    for ALB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALB gene
    AFM2  GC2  AFP2  
    2 SIMAP similar genes for ALB using alignment to 8 protein entries:     ALBU_HUMAN (see all proteins):
    AFP    AFM

    ALB for paralogs           About GeneDecksing



    Genomic Variants
    for ALB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
    Polymorphism: A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic
    augmentation of zinc concentration in the blood. The sequence shown is that of variant albumin A


    Human Gene Mutation Database (HGMD): ALB

    Locus Specific Mutation Databases (LSDB): ALB

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    Disorders / Diseases
    for ALB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ALB for disorders           About GeneDecksing

    OMIM gene information: 103600   
    OMIM disorders: 194470  
    UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
  • Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:103600]. FDH is a form of
    • euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of
    inherited euthyroid hyperthyroxinemia in Caucasian population

    20/531 diseases for ALB (see all 531):    About MalaCards
    protein-losing enteropathy    protein-energy malnutrition    hypoproteinemia, hypercatabolic    cronkhite-canada syndrome
    twin-to-twin transfusion syndrome    apo a-i deficiency    open-angle glaucoma    pure red-cell aplasia
    heparin-induced thrombocytopenia    capillary leak syndrome    maple syrup urine disease    twin twin transfusion syndrome
    dysalbuminemic hyperzincemia    tick-borne encephalitis    spinal cord injury    intestinal pseudo-obstruction
    porphyria cutanea tarda    immune-complex glomerulonephritis    steroid-resistant nephrotic syndrome    hydrops fetalis

    20/68 diseases from the University of Copenhagen DISEASES database for ALB (see all 68):
    Diabetes mellitus     Proteinuria     Liver disease     Kidney failure
    Hypertension     Nephrotic syndrome     Lung disease     Nephritis
    protein-energy malnutrition     Peritonitis     protein-losing enteropathy     Hepatocellular carcinoma
    Heart disease     Anemia     Kernicterus     Hepatitis B
    Bilirubin metabolic disorder     Cerebrovascular accident     Hypersensitivity reaction type II disease     Peripheral vascular disease

    10/96 Novoseek disease relationships for ALB gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    microalbuminuria 94.9 1034 7634745 (5), 9759691 (5), 15717883 (5), 12788992 (4) (see all 99)
    albuminuria 92.5 360 16703327 (5), 17405790 (5), 10489399 (4), 9179466 (4) (see all 99)
    hypoalbuminemia 90.4 275 1569418 (4), 19615208 (4), 9397418 (4), 10428270 (3) (see all 99)
    diabetic nephropathies 89.2 362 1881577 (4), 8264568 (3), 11131103 (3), 10198605 (3) (see all 99)
    renal disease 87 640 8163055 (4), 8593760 (4), 19729498 (3), 17928473 (3) (see all 99)
    proteinuria 86.2 625 12521234 (5), 9915226 (5), 16425574 (5), 1831839 (5) (see all 99)
    malnutrition 86 406 17957127 (4), 19218044 (4), 11592443 (3), 17321950 (3) (see all 99)
    renal failure chronic 80.6 103 2082760 (2), 1951474 (2), 9101098 (2), 1282889 (1) (see all 98)
    nephrotic syndrome 79.7 186 2082057 (6), 8502517 (5), 1379421 (3), 15481604 (3) (see all 99)
    protein-energy malnutrition 76.8 30 10219494 (2), 15695952 (2), 9106105 (1), 10433138 (1) (see all 24)

    Genetic Association Database (GAD): ALB
    Human Genome Epidemiology (HuGE) Navigator: ALB (17 documents)

    Export disorders for ALB gene to outside databases

    Publications
    for ALB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALB gene, integrated from 9 sources (see all 8810):
    (articles sorted by number of sources associating them with ALB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids. (PubMed id 11743713)1, 2, 7 Petitpas I.... Curry S. (2001)
    2. Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. (PubMed id 7852505)1, 2, 9 Rushbrook J.I.... Divino C.M. (1995)
    3. [The interaction of vitamin B6 with the human serum albumin] (PubMed id 16201370)1, 7, 9 Wang J.L....Song Z.F. (2005)
    4. A nucleotide insertion and frameshift cause albumin Kenitra, an extended and O-glycosylated mutant of human serum albumin with two additional disulfide bridges. (PubMed id 11168369)1, 2, 9 Minchiotti L....Galliano M. (2001)
    5. Crystal structure of human serum albumin at 2.5-A resolution. (PubMed id 10388840)1, 2, 9 Sugio S.... Kobayashi K. (1999)
    6. Protein and DNA sequence analysis of a 'private' genetic variant: albumin Ortonovo (Glu-505-->Lys). (PubMed id 7902134)1, 2, 9 Galliano M.... Putnam F.W. (1993)
    7. Two alloalbumins with identical electrophoretic mobility are produced by differently charged amino acid substitutions. (PubMed id 1347703)1, 2, 9 Minchiotti L.... Porta F. (1992)
    8. Genetic variants of serum albumin in Americans and Japanese. (PubMed id 1946412)1, 2, 9 Madison J.... Putnam F.W. (1991)
    9. Allostery in a monomeric protein: the case of human s erum albumin. (PubMed id 20346571)1, 7 Ascenzi P. and Fasano M. (2010)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for ALB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing ALB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 213 HGNC: 399 AceView: ALB Ensembl:ENSG00000163631 euGenes: HUgn213
    ECgene: ALB H-InvDB: ALB

    Other Databases showing ALB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ALB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALB Pharmacogenomics, SNPs, Pathways
    Albumin Websitehttp://www.albumin.org
    Wikipedia http://en.wikipedia.org/wiki/Serum_albumin
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ALB
    SeattleSNPshttp://pga.gs.washington.edu/data/alb/

    Intellectual Property
    for ALB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ALB gene:
    Search GeneIP for patents involving ALB

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