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Aliases for ALB Gene

Aliases for ALB Gene

  • Albumin 2 3 5
  • Cell Growth Inhibiting Protein 42 3
  • Growth-Inhibiting Protein 20 3
  • Albumin (32 AA) 3
  • Albumin (AA 34) 3
  • PRO0883 3
  • PRO0903 3
  • PRO1341 3
  • ANALBA 3
  • FDAH 3

External Ids for ALB Gene

Previous GeneCards Identifiers for ALB Gene

  • GC04P074259
  • GC04P074509
  • GC04P074670
  • GC04P074736
  • GC04P074635
  • GC04P070083

Summaries for ALB Gene

Entrez Gene Summary for ALB Gene

  • Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALB Gene

ALB (Albumin) is a Protein Coding gene. Diseases associated with ALB include analbuminemia and congenital analbuminemia. Among its related pathways are Ca, cAMP and Lipid Signaling and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include enzyme binding and chaperone binding. An important paralog of this gene is AFM.

UniProtKB/Swiss-Prot for ALB Gene

  • Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Gene Wiki entry for ALB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALB Gene

Genomics for ALB Gene

Regulatory Elements for ALB Gene

Enhancers for ALB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ALB on UCSC Golden Path with GeneCards custom track

Genomic Location for ALB Gene

Chromosome:
4
Start:
73,397,114 bp from pter
End:
73,421,412 bp from pter
Size:
24,299 bases
Orientation:
Plus strand

Genomic View for ALB Gene

Genes around ALB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALB Gene

Proteins for ALB Gene

  • Protein details for ALB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02768-ALBU_HUMAN
    Recommended name:
    Serum albumin
    Protein Accession:
    P02768
    Secondary Accessions:
    • E7ESS9
    • O95574
    • P04277
    • Q13140
    • Q645G4
    • Q68DN5
    • Q6UXK4
    • Q86YG0
    • Q8IUK7
    • Q9P157
    • Q9P1I7
    • Q9UHS3
    • Q9UJZ0

    Protein attributes for ALB Gene

    Size:
    609 amino acids
    Molecular mass:
    69367 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF22034.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF69644.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAG35503.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ALB Gene

    Alternative splice isoforms for ALB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALB Gene

Proteomics data for ALB Gene at MOPED

Post-translational modifications for ALB Gene

  • Acetylated on Lys-223 by acetylsalicylic acid.
  • Glycated in diabetic patients.
  • Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.
  • Phosphorylated by FAM20C in the extracellular medium.
  • Ubiquitination at Lys 229
  • Glycosylation at Lys 36, Lys 75, Lys 161, Lys 186, Lys 223, Lys 249, Lys 257, Lys 300, Lys 305, Lys 337, Lys 341, Asn 342, Lys 347, Lys 375, Lys 402, Lys 437, Thr 444, Lys 463, Lys 468, Asp 518, Lys 549, Lys 558, Lys 560, Lys 569, and Lys 597
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ALB (albumin)

No data available for DME Specific Peptides for ALB Gene

Domains & Families for ALB Gene

Suggested Antigen Peptide Sequences for ALB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02768

UniProtKB/Swiss-Prot:

ALBU_HUMAN :
  • Contains 3 albumin domains.
  • Belongs to the ALB/AFP/VDB family.
Domain:
  • Contains 3 albumin domains.
Family:
  • Belongs to the ALB/AFP/VDB family.
genes like me logo Genes that share domains with ALB: view

No data available for Gene Families for ALB Gene

Function for ALB Gene

Molecular function for ALB Gene

GENATLAS Biochemistry:
albumin,putative down-regulated c-Myc target gene,
UniProtKB/Swiss-Prot Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Gene Ontology (GO) - Molecular Function for ALB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 16405401
GO:0005507 copper ion binding NAS 14726550
GO:0016209 antioxidant activity NAS 14726550
genes like me logo Genes that share ontologies with ALB: view
genes like me logo Genes that share phenotypes with ALB: view

Human Phenotype Ontology for ALB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ALB Gene

MGI Knock Outs for ALB:

Animal Model Products

  • Taconic Biosciences Mouse Models for ALB

miRNA for ALB Gene

miRTarBase miRNAs that target ALB

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ALB Gene

Localization for ALB Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALB Gene COMPARTMENTS Subcellular localization image for ALB gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 5
nucleus 5
cytosol 4
cytoskeleton 3
lysosome 3
mitochondrion 3
plasma membrane 3
vacuole 3
chloroplast 2
endosome 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for ALB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
GO:0005783 endoplasmic reticulum IDA --
genes like me logo Genes that share ontologies with ALB: view

Pathways & Interactions for ALB Gene

genes like me logo Genes that share pathways with ALB: view

Gene Ontology (GO) - Biological Process for ALB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA,TAS 12617161
GO:0009267 cellular response to starvation IDA 16245148
GO:0010033 response to organic substance IEA --
GO:0030168 platelet activation TAS --
GO:0043066 negative regulation of apoptotic process IDA 16153637
genes like me logo Genes that share ontologies with ALB: view

No data available for SIGNOR curated interactions for ALB Gene

Drugs & Compounds for ALB Gene

(205) Drugs for ALB Gene - From: DrugBank, ApexBio, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ibuprofen Approved Pharma Channel blocker, Carrier 467
Vandetanib Approved April 2011 Pharma Carrier, binder VEGFR, EGFR, and RET inhibitor, EGFR Inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Estrone Approved Pharma Agonist, Carrier Estrogenic hormone 19
Liothyronine Approved Pharma Carrier 0
Testosterone Approved, Investigational Pharma Carrier, other/unknown Endogenous androgen receptor agonist 519

(73) Additional Compounds for ALB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
estrone sulfate
  • Conestoral
  • Estrogenic substances
  • Estrone
  • Estrone hydrogen sulfate
  • Estrone hydrogen sulphate
481-97-0

(1) ApexBio Compounds for ALB Gene

Compound Action Cas Number
p-Cresyl sulfate Protein-bound uremic retention solute 3233-58-7
genes like me logo Genes that share compounds with ALB: view

Transcripts for ALB Gene

Unigene Clusters for ALB Gene

Albumin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a ·
SP1: - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - -
SP6: -
SP7: - - -
SP8: - -
SP9:
SP10:

ExUns: 14b ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for ALB Gene

GeneLoc Exon Structure for
ALB
ECgene alternative splicing isoforms for
ALB

Expression for ALB Gene

mRNA expression in normal human tissues for ALB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALB Gene

This gene is overexpressed in Liver (x51.9).

Protein differential expression in normal tissues from HIPED for ALB Gene

This gene is overexpressed in Nasopharynx (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALB Gene



SOURCE GeneReport for Unigene cluster for ALB Gene Hs.418167

mRNA Expression by UniProt/SwissProt for ALB Gene

P02768-ALBU_HUMAN
Tissue specificity: Plasma.
genes like me logo Genes that share expression patterns with ALB: view

Protein tissue co-expression partners for ALB Gene

Primer Products

In Situ Assay Products

Orthologs for ALB Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ALB 35
  • 82.32 (n)
  • 76.44 (a)
ALB 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALB 35
  • 82.43 (n)
  • 80.4 (a)
ALB 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alb 35
  • 77.08 (n)
  • 72.37 (a)
Alb 16
Alb 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ALB 35
  • 99.34 (n)
  • 98.85 (a)
ALB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alb 35
  • 76.26 (n)
  • 73.52 (a)
oppossum
(Monodelphis domestica)
Mammalia ALB 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALB 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves ALB 35
  • 60.37 (n)
  • 47.95 (a)
ALB 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cars2 35
  • 54.04 (n)
  • 39.87 (a)
Species with no ortholog for ALB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ALB Gene

ENSEMBL:
Gene Tree for ALB (if available)
TreeFam:
Gene Tree for ALB (if available)

Paralogs for ALB Gene

Paralogs for ALB Gene

(2) SIMAP similar genes for ALB Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ALB: view

Variants for ALB Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ALB Gene

P02768-ALBU_HUMAN
A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood. The sequence shown is that of variant albumin A.

Sequence variations from dbSNP and Humsavar for ALB Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_000499 -
VAR_000500 -
VAR_000501 -
VAR_000502 -
VAR_000503 -

Structural Variations from Database of Genomic Variants (DGV) for ALB Gene

Variant ID Type Subtype PubMed ID
nsv879490 CNV Gain 21882294
dgv956e199 CNV Deletion 23128226
esv274665 CNV Insertion 20981092
nsv879491 CNV Loss 21882294

Variation tolerance for ALB Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALB Gene

HapMap Linkage Disequilibrium report
ALB
Human Gene Mutation Database (HGMD)
ALB

Disorders for ALB Gene

MalaCards: The human disease database

(236) MalaCards diseases for ALB Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ALB in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ALBU_HUMAN
  • Analbuminemia (ANALBA) [MIM:616000]: A rare autosomal recessive disorder manifested by the presence of a very low amount of circulating serum albumin. Affected individuals manifest mild edema, hypotension, fatigue, and, occasionally, lower body lipodystrophy (mainly in adult females). The most common biochemical finding is hyperlipidemia, with a significant increase in the total and LDL cholesterol concentrations, but normal concentrations of HDL cholesterol and triglycerides. {ECO:0000269 PubMed:8134387}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hyperthyroxinemia, familial dysalbuminemic (FDAH) [MIM:615999]: A disorder characterized by abnormally elevated levels of total serum thyroxine (T4) in euthyroid patients. It is due to abnormal serum albumin that binds T4 with enhanced affinity. {ECO:0000269 PubMed:7852505, ECO:0000269 PubMed:8048949, ECO:0000269 PubMed:9329347, ECO:0000269 PubMed:9589637}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ALB

Genetic Association Database (GAD)
ALB
Human Genome Epidemiology (HuGE) Navigator
ALB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALB
genes like me logo Genes that share disorders with ALB: view

No data available for Genatlas for ALB Gene

Publications for ALB Gene

  1. A nucleotide insertion and frameshift cause albumin Kenitra, an extended and O-glycosylated mutant of human serum albumin with two additional disulfide bridges. (PMID: 11168369) Minchiotti L. … Galliano M. (Eur. J. Biochem. 2001) 3 4 23 67
  2. Identification of human plasma proteins as major clients for the extracellular chaperone clusterin. (PMID: 19996109) Wyatt A.R. … Wilson M.R. (J. Biol. Chem. 2010) 3 23
  3. Human serum albumin binding ibuprofen: a 3D description of the unfolding pathway in urea. (PMID: 20117876) Galantini L. … Pavel N.V. (Biophys. Chem. 2010) 23 25
  4. Influence of non-enzymatic post-translation modifications on the ability of human serum albumin to bind iron. Implications for non-transferrin-bound iron speciation. (PMID: 19505594) Silva A.M. … Hider R.C. (Biochim. Biophys. Acta 2009) 3 23
  5. Human serum albumin inhibits Abeta fibrillization through a "monomer-competitor" mechanism. (PMID: 19883602) Milojevic J. … Melacini G. (Biophys. J. 2009) 3 23

Products for ALB Gene

  • Addgene plasmids for ALB

Sources for ALB Gene

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