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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALB Gene

protein-coding   GIFtS: 70
GCID: GC04P074259

Albumin

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
albumin1 2     Albumin (AA 34)2
PRO08832     Cell Growth Inhibiting Protein 422
PRO09032     Growth-Inhibiting Protein 202
PRO13412     Serum Albumin2
Albumin (32 AA)2     

External Ids:    HGNC: 3991   Entrez Gene: 2132   Ensembl: ENSG000001636317   OMIM: 1036005   UniProtKB: P027683   

Export aliases for ALB gene to outside databases

Previous GC identifers: GC04P074509 GC04P074670 GC04P074736 GC04P074635 GC04P070083


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALB Gene:
Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin
functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in
stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight
65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed
before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn
cleaved in the Golgi vesicles to produce the secreted albumin. (provided by RefSeq, Jul 2008)

GeneCards Summary for ALB Gene: 
ALB (albumin) is a protein-coding gene. Diseases associated with ALB include hepatorenal syndrome, and dysalbuminemic hyperthyroxinemia, and among its related super-pathways are Lipoprotein metabolism and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include drug binding and enzyme binding. An important paralog of this gene is AFM.

UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+),
fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure
of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc

Gene Wiki entry for ALB (Serum albumin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_022778.16  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALB gene promoter:
         STAT5B   TBP   STAT1   STAT4   STAT1beta   STAT5A   STAT1alpha   C/EBPalpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 15): ALB promoter sequence
   Search SABiosciences Chromatin IP Primers for ALB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

ALB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALB gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074259:  view genomic region     (about GC identifiers)

Start:
74,262,831 bp from pter      End:
74,287,129 bp from pter
Size:
24,299 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768 (See protein sequence)
Recommended Name: Serum albumin precursor  
Size: 609 amino acids; 69367 Da
Subcellular location: Secreted
Caution: A peptide arising from positions 166 to 174 was originally (PubMed:3087352 and PubMed:2437111) termed
neurotensin-related peptide (NRP) or kinetensin and was thought to regulate fat digestion, lipid absorption, and
blood flow
Sequence caution: Sequence=AAF22034.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAF69644.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAG35503.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
6/77 PDB 3D structures from and Proteopedia for ALB (see all 77):
1AO6 (3D)        1BJ5 (3D)        1BKE (3D)        1BM0 (3D)        1E78 (3D)        1E7A (3D)    
Secondary accessions: O95574 P04277 Q13140 Q645G4 Q68DN5 Q6UXK4 Q86YG0 Q9P157 Q9P1I7 Q9UHS3
Q9UJZ0
Alternative splicing: 2 isoforms:  P02768-1   P02768-2   

Explore the universe of human proteins at neXtProt for ALB: NX_P02768

Explore proteomics data for ALB at MOPED 

Post-translational modifications:

  • UniProtKB: Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and
    Cys-601 to Cys-606
  • UniProtKB: Glycated in diabetic patients
  • UniProtKB: Phosphorylation sites are present in the extracellular medium
  • UniProtKB: Acetylated on Lys-223 by acetylsalicylic acid
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P02768

  • ALB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALB Protein Expression
    REFSEQ proteins: NP_000468.1  
    ENSEMBL proteins: 
     ENSP00000392541   ENSP00000295897   ENSP00000401820   ENSP00000423727   ENSP00000421027  
     ENSP00000422784   ENSP00000384695   ENSP00000426179  
    Reactome Protein details: P02768
    Human Recombinant Protein Products for ALB: 
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    Enzo Life Sciences proteins for ALB
    OriGene Purified Protein for ALB
    OriGene Protein Over-expression Lysate for ALB
    OriGene MassSpec for ALB 
    OriGene Custom Protein Services for ALB
    GenScript Custom Purified and Recombinant Proteins Services for ALB
    Novus Biologicals ALB Proteins
    Novus Biologicals ALB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ALB
    Cloud-Clone Corp. Proteins for ALB 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IDA19996109
    GO:0005737cytoplasm ----
    GO:0031093platelet alpha granule lumen TAS--

    ALB for ontologies           About GeneDecksing



    ALB Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for ALB
    Cloud-Clone Corp. Antibodies for ALB 
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    LSBio Antibodies in human, mouse, rat for ALB 

    Assay Products for ALB: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ALB 
    Cloud-Clone Corp. CLIAs for ALB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR020858 Serum_albumin-like
     IPR000264 ALB/AFP/VDB
     IPR014760 Serum_albumin_N
     IPR020857 Serum_albumin_CS
     IPR021177 Serum_albumin/AFP

    Graphical View of Domain Structure for InterPro Entry P02768

    ProtoNet protein and cluster: P02768

    1 Blocks protein domain: IPB000264 Serum albumin family

    UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
    Similarity: Belongs to the ALB/AFP/VDB family
    Similarity: Contains 3 albumin domains


    ALB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALBU_HUMAN, P02768
    Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+),
    fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure
    of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc

         Genatlas biochemistry entry for ALB:
    albumin,putative down-regulated c-Myc target gene,

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA16405401
    GO:0005504fatty acid binding NAS9731778
    GO:0005507copper ion binding NAS14726550
    GO:0005515protein binding IPI16099937
    GO:0008144drug binding NAS10940303
         
    ALB for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Alb):
     digestive/alimentary  homeostasis/metabolism  liver/biliary system  mortality/aging  normal 
     renal/urinary system  tumorigenesis 

    ALB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ALB: Albtm1Lex Afp/AlbAfp/tm1.1Brts

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALB 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALB
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ALB
    SwitchGear 3'UTR luciferase reporter plasmidALB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALB

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ALB

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ALB (see all 8)
    OriGene ORF clones in mouse, rat for ALB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALB (NM_000477)
    Sino Biological Human cDNA Clone for ALB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALB
    Sirion Biotech Customized lentivirus for stable overexpression of ALB 
                         Customized lentivirus expression plasmids for stable overexpression of ALB 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALB About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Lipoprotein metabolism
    Lipoprotein metabolism0.57
    Lipid digestion, mobilization, and transport0.56
    HDL-mediated lipid transport0.57
    2Platelet degranulation
    Platelet degranulation 0.94
    Response to elevated platelet cytosolic Ca2+0.94
    3Synthesis of bile acids and bile salts
    Bile acid and bile salt metabolism0.74
    Recycling of bile acids and salts0.35
    4Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.63
    Scavenging of Heme from Plasma0.63
    5SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ALB
        Selected targets of HNF1
    Selected targets of C/EBPalpha


    1 Cell Signaling Technology (CST) Pathway for ALB
        Ca, cAMP and Lipid Signaling

    2 BioSystems Pathways for ALB
        Selenium Pathway
    FOXA2 and FOXA3 transcription factor networks


    5/17        Reactome Pathways for ALB (see all 17)
        Metabolism
    Recycling of bile acids and salts
    Response to elevated platelet cytosolic Ca2+
    Transmembrane transport of small molecules
    SLC-mediated transmembrane transport



    ALB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/260 Interacting proteins for ALB (P027682, 3 ENSP000002958974) via UniProtKB, MINT, STRING, and/or I2D (see all 260)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IMMTQ168912, 3, ENSP000003872624MINT-8258723 I2D: score=2 STRING: ENSP00000387262
    PFDN1O609252, 3MINT-8265687 I2D: score=2 
    TK1P041832, 3MINT-8272905 I2D: score=2 
    ENSG00000237112Q9UBS53, ENSP000004112864I2D: score=1 STRING: ENSP00000411286
    ENSG00000206466Q9UBS53I2D: score=1 
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0006810transport TAS12617161
    GO:0006950response to stress ----
    GO:0007584response to nutrient IEA--
    GO:0007596blood coagulation TAS--

    ALB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALB (ALBU)

    10 HMDB Compounds for ALB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Bilirubin(4Z,15Z)-Bilirubin IXa (see all 17)635-65-418498776
    BismuthBi (see all 2)7440-69-9--
    ChlorpheniramineChlor-trimeton (see all 8)113-92-8--
    Estrone(+)-Estrone (see all 7)53-16-7--
    Estrone sulfateConestoral (see all 12)481-97-0--
    Ibuprofenalpha-(4-Isobutylphenyl)propionate (see all 9)15687-27-1--
    Liothyronine3,3',5-Triiodo-L-thyronine (see all 20)6893-02-3--
    Pyridoxine2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine (see all 16)65-23-6--
    Sodium lauryl sulfateAdeka Hope LS 35 (see all 243)151-21-3--
    Testosterone(+)-testosterone (see all 86)58-22-0--

    10/134 DrugBank Compounds for ALB (see all 134)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sodium lauryl sulfateDodecyl alcohol, hydrogen sulfate, sodium salt (see all 27)151-21-3carrierbinder16457837 16085141 16256620 16256532 11752352 16379295
    CefoperazoneCefoperazono [inn-spanish] (see all 2)62893-19-0carrierother/unknown2311445 2496656 3339510 16379298 8950041
    PhenprocoumonFenprocumone [DCIT] (see all 5)435-97-2carrier--1205658 1642965 4762907 2751413 12543492
    Auranofin-- 34031-32-8carrier--11666224 7925457 2403377 3655788
    CaptoprilCaptoprilum [INN-Latin] (see all 3)62571-86-2carrierother/unknown16469467 8216349 9040098 15093593
    Diflunisal-- 22494-42-4carrier--17132209 11673972 7371361 2751413
    DigitoxinDigitoksin (see all 3)71-63-6carrier--11678517 10774625 10604823 10202961
    Ethacrynic acidEtacrinic acid (see all 6)58-54-8carrier--9275312 3714803 9863950 2792351
    Gadobenate Dimeglumine-- 113662-23-0carrierbinder9055236 16118549 11752352 9406019
    Gadofosveset trisodiumAblavar (see all 4)193901-90-5carriersubstrate16706555 19222207 17625839 17650553

    10/140 Novoseek inferred chemical compound relationships for ALB gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 90.6 3964 10727680 (8), 8831085 (7), 9080259 (7), 17405790 (7) (see all 99)
    fibrinogen 83.7 1545 16703327 (7), 9610611 (7), 11422756 (7), 12969171 (7) (see all 99)
    cholesterol 79.9 2000 15082432 (7), 8524502 (6), 18563300 (6), 17279492 (5) (see all 99)
    rhsa 78.5 72 9167443 (2), 10502345 (2), 18199895 (2), 9688461 (2) (see all 38)
    dansylsarcosine 78.2 30 1382424 (6), 9430764 (3), 8720306 (2), 1706921 (2) (see all 16)
    urea 77.8 659 8366899 (5), 8573919 (4), 17361319 (4), 10666933 (4) (see all 99)
    uric acid 76.4 495 10910618 (5), 10898045 (4), 18442624 (4), 16554340 (3) (see all 99)
    hydroxyethyl starch 76.4 487 10703679 (8), 11515893 (7), 9261899 (6), 10361869 (6) (see all 99)
    glucose 73.8 1576 19349048 (6), 9103700 (6), 8575721 (6), 16920285 (5) (see all 99)
    fructosamine 71.2 212 10326628 (7), 1597333 (5), 8893144 (5), 8502341 (5) (see all 95)

    Search CenterWatch for drugs/clinical trials and news about ALB / ALBU

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALB gene: 
    NM_000477.5  

    Unigene Clusters for ALB:

    Albumin
    Hs.418167  [show with all ESTs], Hs.592379  [show with all ESTs]
    Unigene Representative Sequences: NM_000477, BX436222
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441319 ENST00000295897(uc003hgs.4 uc011cbe.2 uc003hgw.4 uc011cbf.2)
    ENST00000510166 ENST00000515133 ENST00000415165 ENST00000514786 ENST00000476441
    ENST00000503124 ENST00000509063 ENST00000401494 ENST00000505649 ENST00000511370
    ENST00000507673 ENST00000484992 ENST00000504043 ENST00000486939 ENST00000508932
    ENST00000495173
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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    OriGene ORF clones in mouse, rat for ALB
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    GenScript: all cDNA clones in your preferred vector: ALB (NM_000477)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALB
    Sirion Biotech Customized lentivirus for stable overexpression of ALB 
                         Customized lentivirus expression plasmids for stable overexpression of ALB 
    Primer
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    OriGene qPCR primer pairs and template standards for ALB
    OriGene qSTAR qPCR primer pairs in human, mouse for ALB
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALB

    Additional mRNA sequence: X51365.1 

    24/209 DOTS entries (see all 209):

    DT.100864734  DT.98132054  DT.95377482  DT.100746389  DT.87011119  DT.100861910  DT.100746447  DT.100746541 
    DT.91816166  DT.95377906  DT.95376610  DT.100746432  DT.95376706  DT.100844172  DT.95376678  DT.100861974 
    DT.100746557  DT.100746613  DT.95376631  DT.91998425  DT.92056056  DT.98132061  DT.100746529  DT.95376639 

    3197 AceView cDNA sequences (see top 24):

    CB154190 CB137645 AI114852 AA330058 BX445228 BG617320 AW779704 T40728 
    AU120853 T61204 BG569475 BG618550 D11974 CR594508 AL531773 CR617173 
    CB154103 CB154090 AI064742 BX462898 BG568563 BX423747 BX427484 CB117011 
    CR618825 T41022 BG563690 BG568381 BX427558 BG617841 BG533253 AL557825 
    BX462915 CR622690 AA334583 AA343473 D17171 BG568551 CR617306 BG617571 
    AI338727 BX422293 AL557822 BG563203 BX406422 BX400104 AL557840 CR625546 
    AI187111 BX400100 BX951534 AI207567 T40937 BX495682 CR618745 BG569034 
    BG565833 AI110642 BX494684 BG618756 CR593996 AU121150 T71587 BX643316 
    AL564786 CR613537 BX361723 CR620317 AL532143 BX494787 CR604028 AL558656 
    BG564176 AA342380 BX443933 AI139674 CR592642 CR596141 AA343334 CR613656 
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    CB147350 BX494862 BG564382 AI373319 BG567421 BX496953 BX447915 AL579949 
    AL564312 AL564251 BG565376 CB115655 BX507397 BX426808 BX507374 AV685417 
    BG565514 BX507338 BX423838 BG567918 BX325034 BG562588 BX496171 AI064758 
    BX956278 BG617810 BG569446 BX494760 AU120899 BX494454 AA342692 AA342371 
    BG618071 BG562524 BX499075 BG545285 T41012 BG565840 AA334810 BX494569 
    BG569584 AU120831 BX346203 T95338 BG567983 AV687308 BG562906 BG618377 
    AA313105 BX494863 BG567408 BX494603 BX505490 BX494937 BG567223 BX405616 
    AI133120 BX494370 AL531845 BX422278 BX406290 BG564159 BG565324 AI133207 
    BX506420 BX449082 BG569108 CB153866 BX405760 BX494935 R29640 BG618091 
    BX509085 CB148967 BX643443 AV681715 BG567423 AV692452 BX495034 AA788868 
    BX646858 BG567771 BX423724 T58849 BX448002 BG617994 BG569453 AV687014 
    AI114750 AV696099 AV683407 T46889 BX462967 AI766232 AA334140 BG568790 
    BX494501 AL532229 BX497107 AA333704 BG618388 BX498093 H62140 AI133525 
    BX495020 CB153814 BX448359 AI110799 CB113513 BX494401 BX464181 BG563142 
    AV684140 BG562459 CB147223 BX643293 BG569673 N64454 BX509042 BG568677 
    BX495440 AI065050 CB142739 BX951487 BX495156 BG565700 AI989725 BF105265 
    BX498302 BG617162 AV688062 BX497022 CB111919 BX498839 BG565646 R28763 
    AV683930 BX495035 AF190168 CB147188 BX494970 BG568321 AI110779 BX427060 
    CB117052 BX426739 BX506608 AV689412 BX495001 BX367187 BX448277 AI207694 
    BG566738 BG617659 BG568152 BX494577 AL579827 T55693 BX497305 N74333 
    BG566374 BX346108 BG618003 BG618194 CB154711 BX496267 BX499106 BX494885 
    BX346223 AL564582 BX500990 BE326964 BG562871 CB141743 BX406759 BX361747 
    BX448306 BG568864 CB154141 BG533390 AV688410 AA313523 BG617949 BM918840 
    BG617193 BG564331 AI061615 BX494558 BG562715 BX497547 T39835 AL531055 
    BX494616 BX494573 BG533541 BX497186 BX494879 BG618292 AI064736 CB153783 
    AA334527 N63649 BG566565 BX507384 BG568293 CB154200 AV683057 BX494875 
    BC041789 BG618102 AL531816 BX494704 BX428026 BG568453 BG533350 BG564888 
    BX506412 BM926765 BG617192 BX494867 BX499187 BG617545 CB142773 AL557929 
    AV684583 BX496470 BX448132 BX506419 BG618453 BX427105 BX427795 CB123002 
    BG618856 BX951542 BG564014 BG618610 T71188 BX494386 BX496899 BG565136 
    AL532184 BG565822 BG563043 BG562968 BG564946 BX427621 BX365466 BX478860 
    AU120645 BX346119 BX426916 BG618354 BG533362 AI628100 T40994 BX495391 
    CB114888 BM721034 BG567245 BG562576 BG568277 AA334461 BG618327 CB142722 
    BX367047 BX497256 BG618173 CB114890 AL558077 BG563669 BX494436 T40050 
    AI132954 BX426786 AL531616 BX643328 BX494539 BG545183 CB122306 BX494582 
    BV204305 BX447982 BX951541 AL557799 BG569488 BX494695 BX494468 BX497214 
    BG568699 BG569336 BG617736 AV687353 BG568765 BC035969 BG617878 BX494813 
    CB153800 BX406311 BX494978 BX494490 BX495090 BX497207 AI207432 BG567141 
    BX496991 BX497079 BG568853 AV691435 AL557939 AV683628 CB138260 BX478547 
    BX509081 AW051713 AV698496 R06691 AI936354 CB163702 BX427794 BX509046 
    BX494474 BX497111 BX506565 AL531673 BX507410 AV693600 BX448101 BG562447 
    BG617963 BX497219 BX494956 BX955700 AU120615 AA343367 BX423835 AF542069 
    AI312883 BX494812 BX495642 AW950619 BX494615 T74865 BG564777 BG617525 
    BG564783 BG566432 BG568878 AI114710 BX497194 AA334608 BX498728 BX494809 
    CB158433 BG617939 BG567978 BG568759 BX494554 BX382947 BX646378 BX406551 
    BG533370 CB121452 AI207520 AI613084 CB154694 BV202313 AV685076 BF126554 
    BX951517 BX643338 BG563343 AV686442 CB120379 BX951485 AI065020 BX448215 
    BX643460 BG618122 BX494900 CB115675 BX496539 BX427133 BX956610 CB154230 
    BX405657 T40961 BG617979 BG618567 BG562589 BX494950 AV698586 BX497015 
    BX447946 BG563039 BX497092 BG562863 AV688476 BG567573 BG618501 CB148259 
    AV686400 AA342801 BG565910 BG562736 BG567394 BG617922 AI796570 AV690490 
    AA343023 BG618105 BX495216 BG565029 AV686090 T40938 AU121038 AL580413 
    BX643332 AV696577 T61120 T39998 AV687060 BG618960 AV651382 BX494402 
    BX496749 AI064826 AA313092 BX496853 BX495553 AV694855 AI061612 AI097221 
    BX507375 BX497529 AI313181 BX464255 AI133263 BX443801 T40075 BC034026 
    BX496691 BX506704 AI949897 BX505611 BG566403 BG564704 BG565490 BX506410 
    BX346157 BX423806 BX494701 T69175 BG616530 D82117 BX427943 BG567579 
    AA342401 BX506562 BG563658 CB115357 BX498115 BG567352 BX447937 BX494786 
    AI133726 BG566697 AI114438 T24032 BX405381 AW027940 BX427638 BG565405 
    BX346075 AI110619 BG563555 BX646860 AV689241 BX494406 AI133684 BX494987 
    BG617359 AV687630 AI207490 AI613071 BX426997 BG567414 AA342193 BG563976 
    BG563966 BX495643 AV690863 BX405474 BX498002 AV687174 R01842 CB162427 
    AI114759 AI133671 BG565496 BX494870 BG564299 NM_000477 CB135178 AV687241 
    AV690725 BX494685 BG401649 BG565918 BG563255 AF063545 BX494858 BG568476 
    AI203974 BG562788 BG564904 BX494650 BF196465 BX497174 BX494497 AV695396 
    BX498469 BX955702 CB116663 BX367120 BX505489 AV695966 AV688742 AI192792 
    BX427130 AA360370 AV692986 BX499264 BX325194 BX346198 BG562861 CB154311 
    BX494593 AV681806 BG565098 BG564047 BG616735 BX494952 AV681931 AI065042 
    AI114504 R29385 BX494779 BX346044 BX427135 BG566620 BX494681 AV684346 
    AL557948 BX494838 BG568833 BG564265 BG569027 CB147157 BX427905 BG566084 
    BX494905 BX509063 AV691486 CB122309 AI114676 BX506480 AI110741 BG564841 
    AA360354 BX388009 CB114898 AI065128 BG618058 AV681693 BX497275 BG618452 
    AV692458 AI133622 AI963890 BX494902 BX646894 BX494491 BG564485 BX387936 
    AI114666 BX448864 BX494555 BX506856 BX494686 CB142735 BX495023 BG617986 
    BX494730 AA313192 BX496526 BX494728 BX496920 BX643388 BG533384 BG617214 
    BX494510 BX643374 BG567871 AV688136 BG617666 AA501730 BX951480 BX494851 
    BX643339 AI207675 CB153867 BX496753 BX643391 BX495855 BX496962 BX494655 
    BG562773 BX494821 BX422297 AI207487 BG563896 AV681550 BE465170 BX509060 
    BX951529 BX427976 BE971240 BG563158 BX509079 BG533422 BX494789 BX494470 
    BG617308 BX494559 AV681970 CB113372 BG565158 BX503297 BG617591 BX406782 
    BX427687 CB137774 BG533261 BG563201 BG563273 BG567808 AL564135 AV681899 
    BX494620 BG564637 BG562867 BX494442 BX496768 BX509045 T67814 BX509069 
    AV687948 AI110671 BX494465 BX423727 BG618534 BG565610 R09237 BX448216 
    BG565237 AL563996 BX463028 BG568556 BX494564 BG533505 BX509027 CB123018 
    BG565949 BG562478 AA342129 BG617943 BG617889 AI064979 AI312891 BX325217 
    BX495515 BX499118 BQ644404 BC014308 BG564388 BG568294 CB121410 T67405 
    BX478154 BX494846 BG562949 T39907 AV689263 BG568141 T40093 BG566001 
    BG564818 BX494613 CB153885 BG566428 BG563943 BX507329 BX494523 BG617088 
    BX495721 BX646882 BX346016 CB154295 AV692305 BX405693 BG617971 BG563897 
    BG562402 BG618716 AV696757 BX448898 CB146627 BX405730 BG565123 BG568683 
    BX951523 BQ064577 BX422310 BG618663 CB116976 BX496672 BX448005 BX346139 
    AV685390 BG545080 AF062727 BG617954 BX498242 BX506644 BX494642 BX643428 
    W20178 T40000 BG617859 V00494 AL564326 BX449015 BX494845 BX643462 
    T40012 AL557960 D11603 T39896 AL557788 AL564714 BX497210 BG568931 
    BG566795 CB141768 BX496801 BG617071 BX507334 AV686894 CB122986 BX382945 
    BG567991 BX494916 BG568063 AA344219 BX494461 BX503452 AL532187 CB124840 
    AA343347 AV691395 BG617879 BX449067 BG618460 BX494413 BG566614 BX509023 
    BX346156 BX496677 BX495011 BX494426 AI065049 T60331 T68819 AU120627 
    BX494662 BG564125 T40876 BX494683 AF074648 AV717963 BG563977 BG564377 
    BG569491 BG565031 AL557744 CB137661 AL531377 BG563105 CB120390 AI337801 
    BX494472 BX506723 BG569605 BX494645 BX506675 D11536 AV687016 AI110629 
    AV682640 AV691830 BG567011 T60970 AV686434 BG564874 CB114886 BX506447 
    T41004 BG567266 BG562521 BX507385 AI628079 BG567217 AV699038 BX494419 
    R29351 CB148267 BG562711 BX346128 BG564276 AI478644 AI140200 BX447935 
    BI764872 BG618464 BX494742 BX447981 BX507364 BX405738 BG566666 BX494919 
    T71003 BX427459 AI207463 BG565970 BX448003 BX494307 AV682633 BG569443 
    AV681904 AL558012 BG618823 BX422189 BX951453 BG565368 BG617061 AU120135 
    BX496800 AI133404 BG568664 BX494617 CB148975 AV684311 CB158445 BG565750 
    AV686712 BX427981 BX496410 CB115402 CB111966 CB141200 AL564504 BX503378 
    AU121201 BX406148 BX494635 BG618062 BX499259 BX367015 AL564574 AI478130 
    AI174724 BE671892 AI114840 CB148253 BG533262 AA343791 CB111929 AV689242 
    AI207542 CB157578 AV683679 AF075298 BG568231 BX496759 BG545232 BX405714 
    BX494521 BX448751 BX506596 AL531135 CB115646 BX406665 AI174690 R28881 
    BX406478 BX346148 AL564489 BG616988 BX497301 AV687997 BG533356 BG564980 
    BX494516 BG568234 AL532040 AU120923 AL564448 BX494824 BX494595 BG563604 
    BX495737 BX494843 BG616721 BG568638 BG567568 T50776 BX405631 BG568505 
    BX495611 BX405709 BX494575 BG563726 T39662 AL579937 CB116969 BX463245 
    AL532008 BG616720 AV685052 AI064689 AI114478 BX506425 BX494792 BX367169 
    AL564136 AV685207 BG563464 BG618836 BG533500 AV698913 AU120322 BG566779 
    BG563522 BX494398 BG545171 AV696784 R98206 CB153842 BX406375 BX427209 
    AI313176 AL563974 AV681691 BX494520 BG564947 BX494637 BG564950 BX463018 
    R28946 BX494933 CB116974 BG567752 CB120380 CB148260 BG618205 BX506707 
    BG569518 AV682304 BX507396 BG568977 CB120375 AV693579 AI174852 BG616893 
    T58858 BG563188 BF740008 BG616687 BG568710 BX494361 T71203 T40962 
    BG568121 T40946 BX494550 BX503393 BX646224 BX494654 BX494886 CB148280 
    AV689071 BX497199 AI150977 CB154120 BQ645094 AL531140 BX951510 BG569188 
    AA334306 BX426884 AF063579 BG616951 BG569607 BX494658 BX496924 AV691266 
    BX373894 AU120701 AV698085 BG562717 BG562945 BF196528 BX497351 BX448804 
    BX478675 BG618272 BF195866 BG566383 AI064701 BG618020 BX494440 AL557966 
    BX494597 BG618046 BX497029 BG617131 BX506656 BX509067 BX444056 BG618463 
    T40172 BX643403 BG568705 CB162153 CB113322 BG563584 BX494820 CB124875 
    BX463004 T68347 AA345784 BX496473 BG568126 BX427745 BX494763 AI133118 
    BG616619 BX325175 BG564703 AV696219 AV683198 BX494940 T40163 BG617863 
    BX367162 BG567386 CB162653 N57903 AA342690 BG617829 BX497018 BX405824 
    BX494917 AA343431 BX509038 AL532003 CB153868 BG566824 BX494529 CB114871 
    CB111931 BG568925 BG533321 AI064855 AL564265 T69564 AV692937 BX497633 
    AI190374 BX956653 BX427151 BX951515 CB142763 AV693803 BX496722 BG568489 
    BQ643982 AL531203 BG569442 BG565011 BX509054 D11839 BX494804 AA343125 
    BX497220 BX509071 BG562643 AI985002 CB120365 AI061595 AV689676 BX497012 
    BX406679 BX494532 BG565697 BX494815 CB154358 T39739 AL558064 AI133473 
    T40045 CB113363 BX494721 BX427980 BG617589 AV685365 AA732830 BX478566 
    BX494458 BG563880 AI114626 R29086 BX506448 CB158465 AV685305 BG569110 
    BX494392 BX346050 BG568409 AI174786 AI132925 BG617106 AI652144 BG618072 
    BX507333 BG569637 BX646799 BG618890 BG618090 BG565639 AL563998 AI174729 
    AI114572 BX497184 BX497467 BX494432 T39981 CB114870 AI444620 BF126547 
    W02621 BX506615 BX498729 BX643354 BX509072 BX325218 BG568522 BX346109 
    BX449017 R29469 AL564625 BG566657 BX405562 BX507414 BX494799 AA334001 
    AV694065 BG618935 BG569106 AI654177 BG618240 CB147219 AL557950 BX494553 
    BG566575 BG566284 CB124883 BG563718 BG616920 T40040 BX494451 BG567092 
    BG565449 CB148976 BX494452 CB115376 BG567035 CB122251 BX499399 BM172063 
    AA342121 BX496356 BX448210 BG562977 T40965 AV694744 BX494800 BX495923 
    BX448707 AA334019 BX494723 CB154305 BX951498 CB154266 BX509024 BX427047 
    W65307 BX448140 AL531615 T69116 AL565686 BX494403 AV693799 BF196427 
    BG565010 BX495483 BX346053 AV687061 BG562651 BX509068 BG564562 AA342578 
    CB148232 BX405431 BG616949 CB114910 BX388044 BX494585 BX367119 CB135244 
    BX444015 BG618717 BX427120 AF075308 AV689405 BG567464 AA334290 BX495018 
    BX494530 AV682667 AI133345 BG565546 BG617980 AA344424 BG569261 AI133100 
    BX494610 CB122953 BX498293 BG562648 AL531139 BX463206 AV691565 BX643355 
    T40032 AL558630 BX494580 BG569283 BX494540 BG567129 BG617626 AU121284 
    BX494583 BX346081 BG566683 AV691680 CD608581 BX494663 BG568869 BX445315 
    BX426661 BX506532 BX643416 BG562422 BX509075 BX497213 BX325193 CB121476 
    BX494628 CB122985 CB137651 BX494703 BX509035 CB141769 BG617149 BX494412 
    BG618602 BX646896 BG562547 BX509041 T40043 BX494679 BX498424 AV684724 
    CB148294 BG568707 BX406402 BQ646699 AV693112 AA342078 CB122280 CB130114 
    T69561 AI174839 CB158427 BX494955 BX494531 BG564957 BG567812 BX507323 
    BX444164 AV691598 BX643424 T55956 BG616943 BX346017 AV693795 BX463015 
    BX506623 CB117054 T71709 CB154223 BG566104 BX325079 BG569436 BX367092 
    BX448297 BX506809 BX406749 BG563349 BG617883 BG569404 BX478794 AI061603 
    BX496976 BX494609 BX496727 BX494543 CR749331 AI065087 BX505463 AA337556 
    V00495 T40749 T40882 AL564029 R28744 AI174713 BX448194 AL579895 
    H90143 N76438 AL579975 AL579786 W05241 AL564067 AV694522 BX506617 
    AV694172 AA342230 AL580408 BX496572 AV694156 T40970 AV685668 T61879 
    AL579783 AL563961 AL564323 AL564320 T56825 T40880 BX325118 T40047 
    AL564325 AL564313 T48227 T40716 AA342736 BG533267 AL579777 T68296 
    AV691912 AV685329 AL532186 AV696991 BG533570 T55237 T61291 AL563957 
    AL564286 AV684709 H72085 BG568492 AA341961 AL579840 AL580418 AL579999 
    T74681 AA948088 AL563932 AV686013 AA342398 AV688139 AL579720 AA343950 
    T67485 AL564121 T95428 AV689797 AL564328 AL564073 AL563968 AL579785 
    AL580002 AL564018 BX427064 AA343176 AV693412 AV695837 BX426979 AL564047 
    BX494657 AL564260 AL579990 T57381 AL564044 AL580427 AL579941 AL579792 
    T61286 T71779 T64684 AV695935 AL564701 T69631 AL564562 T74880 
    AL580419 AL579939 T68695 R09734 AL580007 T60576 AL564163 AL579789 
    W65337 T58917 AL564734 T40952 H47938 AL564267 AV693556 T58966 
    AL564102 BM171974 H90242 AL563981 AL580422 AL564256 T60361 AL563948 
    R09351 T64672 AL579933 T61713 AL564194 BM172086 AL564178 AL579880 
    AL564264 AL579797 W40324 T73776 T57320 T72884 T74548 AL564288 
    T67566 H71366 H71319 T69627 T61335 T57203 AL564509 AL563923 
    AL564156 BG566727 AL563984 T74936 BG533491 BG545099 AL564195 AL564177 
    AL564223 T61233 T48228 R06692 T71739 AL564198 AL564090 AL564193 
    AL564304 T62153 AL564064 T67964 T58905 R98207 T60978 BM172081 
    AL563926 T68361 T51173 T51681 AL580428 AL564245 T70454 R01843 
    AL564248 T58916 T81874 AL564165 AL579870 AL564115 AL579885 AL564179 
    AL579854 AL564183 AL579766 AL579938 T53288 AL579891 T89358 T50808 
    T53918 W35144 AL564164 T53195 T50938 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ALB (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a ·
    SP1:                                                              -                             -                       -                                       
    SP2:                                                  -     -     -     -     -     -     -     -     -     -           -                                       
    SP3:                    -     -     -     -     -     -     -     -     -     -                 -                       -                                       
    SP4:                          -     -     -     -     -     -     -     -     -     -           -                       -                                       
    SP5:                                      -     -     -     -     -     -                       -                                                               

    ExUns: 14b ^ 15 ^ 16a · 16b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ALB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALB expression in normal human tissues (normalized intensities)      ALB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATAAGAG
    ALB Expression
    About this image


    ALB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 15 entries
             Mature Hepatocytes Liver Lobule
             Adult liver progenitor cells
             Hepatocyte-like cells ( Functional hepatocyte generation from human embryonic stem...
             Human Hepatocyte (HH)   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
             cervix   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Endocrine progenitors ( Generation of pancreatic progenitor cells from clinical-grade...
             Pancreatic Islet   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
             colon ; endothelial cells   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             kidney ; cells in tubules   

    See ALB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALB

    SOURCE GeneReport for Unigene clusters: Hs.418167 Hs.592379

    UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
    Tissue specificity: Plasma

        SABiosciences Expression via Pathway-Focused PCR Arrays including ALB: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Oxidative Stress in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ALB
    OriGene qSTAR qPCR primer pairs in human, mouse for ALB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ALB gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alb1 , 5 albumin1, 5 77.1(n)1
    72.49(a)1
      5 (44.70 cM)5
    116571  NM_009654.31  NP_033784.21 
     904608895 
    chicken
    (Gallus gallus)
    Aves ALB1 albumin 60.37(n)
    47.95(a)
      396197  NM_205261.1  NP_990592.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gc6
    group-specific component (vitamin D binding protei...
    20(a)
    1 → many
    5(47282879-47303096)


    ENSEMBL Gene Tree for ALB (if available)
    TreeFam Gene Tree for ALB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALB gene
    AFM2  GC2  AFP2  
    2 SIMAP similar genes for ALB using alignment to 8 protein entries:     ALBU_HUMAN (see all proteins):
    AFP    AFM

    ALB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
    Polymorphism: A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic
    augmentation of zinc concentration in the blood. The sequence shown is that of variant albumin A


    10/598 SNPs in ALB are shown (see all 598)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0130114
    Familial dysalbuminemic hyperthyroxinemia (FDH)4--see VAR_0130112 L P mis40--------
    VAR_0005144
    Familial dysalbuminemic hyperthyroxinemia (FDH)4--see VAR_0005142 R H mis40--------
    VAR_0130134
    Familial dysalbuminemic hyperthyroxinemia (FDH)4--see VAR_0130132 R P mis40--------
    rs774081631,2
    Cpathogenic174148127(+) TGCACA/GTAAGA 1 -- spd10--------
    rs778923781,2
    Cpathogenic174150480(+) ATCACC/TTGTAA 2 P L mis10--------
    rs773353741,2
    Cpathogenic174155714(+) TTTTTA/G/TGGGCA 1 -- spa11CSA 1
    rs750026281,2
    Cpathogenic174155727(+) AGCTCA/C/GCCTGA 3 H P R mis10--------
    rs792280411,2
    Cpathogenic174163355(+) TTGCCA/GAGGAG 2 K E mis10--------
    rs762420871,2
    Cuntested174157309(+) TAAGGA/G/TTGTTT 3 D G V mis10--------
    rs782840521,2,4
    C,Funtested174163244(+) AGCTCG/ATGAAA 2 /M /V mis11Minor allele frequency- A:0.00NA 4548

    HapMap Linkage Disequilibrium report for ALB (74262831 - 74287129 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ALB:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv956e199CNV Deletion23128226
    esv274665CNV Insertion20981092
    nsv879491CNV Loss21882294
    nsv879490CNV Gain21882294


    Human Gene Mutation Database (HGMD): ALB

    Locus Specific Mutation Databases (LSDB): ALB
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ALB
    DNA2.0 Custom Variant and Variant Library Synthesis for ALB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 103600   
    OMIM disorders: 194470  
    UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
  • Familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:103600]: Form of euthyroid hyperthyroxinemia that is
    due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia
    in Caucasian population. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/483 diseases for ALB (see all 483):    About MalaCards
    hepatorenal syndrome    dysalbuminemic hyperthyroxinemia    systemic capillary leak syndrome    bilateral choanal atresia
    blastomycosis    kallikrein hypertension    immunotactoid glomerulopathy    congenital analbuminemia
    dysalbuminemic hyperzincemia    peritonitis    protein-losing enteropathy    metabolic acidosis
    familial dysalbuminemic hyperthyroxinemia    hepatopulmonary syndrome    cronkhite-canada syndrome    hypertensive retinopathy
    tricuspid atresia    scurvy    peptic ulcer perforation    acute generalized exanthematous pustulosis

    20/69 diseases from the University of Copenhagen DISEASES database for ALB (see all 69):
    Diabetes mellitus     Proteinuria     Liver disease     Kidney failure
    Hypertension     Nephrotic syndrome     Lung disease     Nephritis
    Peritonitis     protein-energy malnutrition     protein-losing enteropathy     Hepatocellular carcinoma
    Heart disease     Anemia     Hepatitis B     Cerebrovascular accident
    Kernicterus     Hypersensitivity reaction type II disease     Peripheral vascular disease     Atherosclerosis

    ALB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/96 Novoseek inferred disease relationships for ALB gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    microalbuminuria 94.9 1034 7634745 (5), 9759691 (5), 15717883 (5), 12788992 (4) (see all 99)
    albuminuria 92.5 360 16703327 (5), 17405790 (5), 10489399 (4), 9179466 (4) (see all 99)
    hypoalbuminemia 90.4 275 1569418 (4), 19615208 (4), 9397418 (4), 10428270 (3) (see all 99)
    diabetic nephropathies 89.2 362 1881577 (4), 8264568 (3), 11131103 (3), 10198605 (3) (see all 99)
    renal disease 87 640 8163055 (4), 8593760 (4), 19729498 (3), 17928473 (3) (see all 99)
    proteinuria 86.2 625 12521234 (5), 9915226 (5), 16425574 (5), 1831839 (5) (see all 99)
    malnutrition 86 406 17957127 (4), 19218044 (4), 11592443 (3), 17321950 (3) (see all 99)
    renal failure chronic 80.6 103 2082760 (2), 1951474 (2), 9101098 (2), 1282889 (1) (see all 98)
    nephrotic syndrome 79.7 186 2082057 (6), 8502517 (5), 1379421 (3), 15481604 (3) (see all 99)
    protein-energy malnutrition 76.8 30 10219494 (2), 15695952 (2), 9106105 (1), 10433138 (1) (see all 24)

    Genetic Association Database (GAD): ALB
    Human Genome Epidemiology (HuGE) Navigator: ALB (17 documents)

    Export disorders for ALB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALB gene, integrated from 9 sources (see all 8833):
    (articles sorted by number of sources associating them with ALB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids. (PubMed id 11743713)1, 2, 7 Petitpas I.... Curry S. (2001)
    2. Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. (PubMed id 7852505)1, 2, 9 Rushbrook J.I.... Divino C.M. (1995)
    3. A nucleotide insertion and frameshift cause albumin Kenitra, an extended and O-glycosylated mutant of human serum albumin with two additional disulfide bridges. (PubMed id 11168369)1, 2, 9 Minchiotti L....Galliano M. (2001)
    4. Crystal structure of human serum albumin at 2.5-A resolution. (PubMed id 10388840)1, 2, 9 Sugio S.... Kobayashi K. (1999)
    5. Protein and DNA sequence analysis of a 'private' genetic variant: albumin Ortonovo (Glu-505-->Lys). (PubMed id 7902134)1, 2, 9 Galliano M.... Putnam F.W. (1993)
    6. Two alloalbumins with identical electrophoretic mobility are produced by differently charged amino acid substitutions. (PubMed id 1347703)1, 2, 9 Minchiotti L.... Porta F. (1992)
    7. Genetic variants of serum albumin in Americans and Japanese. (PubMed id 1946412)1, 2, 9 Madison J.... Putnam F.W. (1991)
    8. Allostery in a monomeric protein: the case of human s erum albumin. (PubMed id 20346571)1, 7 Ascenzi P. and Fasano M. (2010)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 213 HGNC: 399 AceView: ALB Ensembl:ENSG00000163631 euGenes: HUgn213
    ECgene: ALB H-InvDB: ALB

    (According to HUGE)