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ALB Gene

protein-coding   GIFtS: 71
GCID: GC04P074259

Albumin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
albumin1 2     Albumin (AA 34)2
PRO08832     Cell Growth Inhibiting Protein 422
PRO09032     Growth-Inhibiting Protein 202
PRO13412     Serum Albumin2
Albumin (32 AA)2     

External Ids:    HGNC: 3991   Entrez Gene: 2132   Ensembl: ENSG000001636317   OMIM: 1036005   UniProtKB: P027683   

Export aliases for ALB gene to outside databases

Previous GC identifers: GC04P074509 GC04P074670 GC04P074736 GC04P074635 GC04P070083


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ALB Gene:
Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin
functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in
stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight
65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed
before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn
cleaved in the Golgi vesicles to produce the secreted albumin. (provided by RefSeq, Jul 2008)

GeneCards Summary for ALB Gene:
ALB (albumin) is a protein-coding gene. Diseases associated with ALB include hepatorenal syndrome, and systemic capillary leak syndrome. GO annotations related to this gene include drug binding and enzyme binding. An important paralog of this gene is AFM.

UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+),
fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure
of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc

Gene Wiki entry for ALB (Serum albumin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALB gene promoter:
         STAT5B   TBP   STAT1   STAT4   STAT1beta   STAT5A   STAT1alpha   C/EBPalpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 15): ALB promoter sequence
   Search Chromatin IP Primers for ALB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

ALB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALB gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074259:  view genomic region     (about GC identifiers)

Start:
74,262,831 bp from pter      End:
74,287,129 bp from pter
Size:
24,299 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768 (See protein sequence)
Recommended Name: Serum albumin precursor  
Size: 609 amino acids; 69367 Da
Caution: A peptide arising from positions 166 to 174 was originally (PubMed:3087352 and PubMed:2437111) termed
neurotensin-related peptide (NRP) or kinetensin and was thought to regulate fat digestion, lipid absorption, and
blood flow
Sequence caution: Sequence=AAF22034.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAF69644.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAG35503.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Selected PDB 3D structures from and Proteopedia for ALB (see all 86):
1AO6 (3D)        1BJ5 (3D)        1BKE (3D)        1BM0 (3D)        1E78 (3D)        1E7A (3D)    
Secondary accessions: O95574 P04277 Q13140 Q645G4 Q68DN5 Q6UXK4 Q86YG0 Q9P157 Q9P1I7 Q9UHS3
Q9UJZ0
Alternative splicing: 2 isoforms:  P02768-1   P02768-2   

Explore the universe of human proteins at neXtProt for ALB: NX_P02768

Explore proteomics data for ALB at MOPED

Post-translational modifications: 

  • Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and
    Cys-601 to Cys-6061
  • Glycated in diabetic patients1
  • Phosphorylation sites are present in the extracellular medium1
  • Acetylated on Lys-223 by acetylsalicylic acid1
  • Ubiquitination2 at Lys229
  • Glycosylation2 at Lys36, Lys75, Lys161, Lys186, Lys223, Lys249, Lys257, Lys300, Lys305, Lys337,
                                 Lys341, Asn342, Lys347, Lys375, Lys402, Lys437, Thr444, Lys463, Lys468, Asp518 (see all 25)
  • Modification sites at PhosphoSitePlus

  • See ALB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000468.1  
    ENSEMBL proteins: 
     ENSP00000392541   ENSP00000295897   ENSP00000401820   ENSP00000423727   ENSP00000421027  
     ENSP00000422784   ENSP00000384695   ENSP00000426179  
    Reactome Protein details: P02768

    ALB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for ALB
    OriGene Purified Protein for ALB
    OriGene Protein Over-expression Lysate for ALB
    OriGene MassSpec for ALB
    OriGene Custom Protein Services for ALB
    GenScript Custom Purified and Recombinant Proteins Services for ALB
    Novus Biologicals ALB Proteins
    Novus Biologicals ALB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ALB
    Cloud-Clone Corp. Proteins for ALB

    ALB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ALB
    R&D Systems Antibodies for ALB (Albumin)
    Cell Signaling Technology (CST) Antibodies for ALB  (albumin)
    OriGene Antibodies for ALB
    OriGene Custom Antibody Services for ALB
    Novus Biologicals ALB Antibodies
    Abcam antibodies for ALB
    Cloud-Clone Corp. Antibodies for ALB
    ThermoFisher Antibody for ALB
    LSBio Antibodies in human, mouse, rat for ALB

    ALB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ALB
    R&D Systems ELISAs for ALB (Albumin)
    GenScript Custom Assay Services for ALB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ALB
    Cloud-Clone Corp. CLIAs for ALB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR000264 ALB/AFP/VDB
     IPR014760 Serum_albumin_N
     IPR020858 Serum_albumin-like
     IPR020857 Serum_albumin_CS
     IPR021177 Serum_albumin/AFP

    Graphical View of Domain Structure for InterPro Entry P02768

    ProtoNet protein and cluster: P02768

    1 Blocks protein domain: IPB000264 Serum albumin family

    UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
    Similarity: Belongs to the ALB/AFP/VDB family
    Similarity: Contains 3 albumin domains


    ALB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALBU_HUMAN, P02768
    Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+),
    fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure
    of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc

         Genatlas biochemistry entry for ALB:
    albumin,putative down-regulated c-Myc target gene,

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA16405401
    GO:0005504fatty acid binding NAS9731778
    GO:0005507copper ion binding NAS14726550
    GO:0005515protein binding IPI16099937
    GO:0008144drug binding NAS10940303
         
    ALB for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Alb):
     cellular  digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism  liver/biliary system 
     mortality/aging  muscle  normal  renal/urinary system  tumorigenesis 

    ALB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ALB: Albtm1Lex Afp/AlbAfp/tm1.1Brts

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ALB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALB

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ALB using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ALB
    SwitchGear 3'UTR luciferase reporter plasmidALB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ALB
    Predesigned siRNA for gene silencing in human, mouse, rat ALB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ALB

    Clone
    Products:
         
    OriGene clones in human, mouse for ALB (see all 8)
    OriGene ORF clones in mouse, rat for ALB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALB (NM_000477)
    Sino Biological Human cDNA Clone for ALB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALB

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ALB
    Browse ESI BIO Cell Lines and PureStem Progenitors for ALB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ALBU_HUMAN, P02768: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton3
    cytosol3
    endoplasmic reticulum3
    mitochondrion3
    nucleus3
    plasma membrane3
    chloroplast2
    endosome2
    golgi apparatus2
    lysosome2
    peroxisome2
    vacuole2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IDA19996109
    GO:0005737cytoplasm ----
    GO:0031093platelet alpha granule lumen TAS--

    ALB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ALB About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Lipoprotein metabolism
    Lipoprotein metabolism0.59
    HDL-mediated lipid transport0.00
    Lipid digestion, mobilization, and transport0.59
    2Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    3Synthesis of bile acids and bile salts
    Bile acid and bile salt metabolism0.73
    Recycling of bile acids and salts0.00
    4Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.53
    Scavenging of Heme from Plasma0.53
    5Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ALB
        Ca, cAMP and Lipid Signaling

    2 BioSystems Pathways for ALB
        Selenium Pathway
    FOXA2 and FOXA3 transcription factor networks


    5 Reactome Pathways for ALB
        Platelet degranulation
    Scavenging of heme from plasma
    Recycling of bile acids and salts
    Transport of organic anions
    HDL-mediated lipid transport



    ALB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ALB: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Oxidative Stress in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ALB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ALB (P027681, 2, 3 ENSP000002958974) via UniProtKB, MINT, STRING, and/or I2D (see all 262)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IMMTQ168912, 3, ENSP000003872624MINT-8258723 I2D: score=2 STRING: ENSP00000387262
    TFRCP027861, 2EBI-714423,EBI-355727 MINT-8413175 MINT-8412660
    PFDN1O609252, 3MINT-8265687 I2D: score=2 
    TK1P041832, 3MINT-8272905 I2D: score=2 
    ENSG00000237112Q9UBS53, ENSP000004112864I2D: score=1 STRING: ENSP00000411286
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    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001895retina homeostasis IEP--
    GO:0002576platelet degranulation TAS--
    GO:0006810transport TAS12617161
    GO:0007584response to nutrient IEA--
    GO:0007596blood coagulation TAS--

    ALB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ALB (ALBU)

    10 HMDB Compounds for ALB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Bilirubin(4Z,15Z)-Bilirubin IXa (see all 17)635-65-418498776
    BismuthBi (see all 2)7440-69-9--
    ChlorpheniramineChlor-trimeton (see all 8)113-92-8--
    Estrone(+)-Estrone (see all 7)53-16-7--
    Estrone sulfateConestoral (see all 12)481-97-0--
    Ibuprofenalpha-(4-Isobutylphenyl)propionate (see all 9)15687-27-1--
    Liothyronine3,3',5-Triiodo-L-thyronine (see all 20)6893-02-3--
    Pyridoxine2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine (see all 16)65-23-6--
    Sodium lauryl sulfateAdeka Hope LS 35 (see all 243)151-21-3--
    Testosterone(+)-testosterone (see all 86)58-22-0--

    Selected DrugBank Compounds for ALB (see all 134)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sodium lauryl sulfateDodecyl alcohol, hydrogen sulfate, sodium salt (see all 27)151-21-3carrierbinder16457837 16085141 16256620 16256532 11752352 16379295
    CefoperazoneCefoperazono [inn-spanish] (see all 2)62893-19-0carrierother/unknown2311445 2496656 3339510 16379298 8950041
    PhenprocoumonFenprocumone [DCIT] (see all 5)435-97-2carrier--1205658 1642965 4762907 2751413 12543492
    Auranofin-- 34031-32-8carrier--11666224 7925457 2403377 3655788
    CaptoprilCaptoprilum [INN-Latin] (see all 3)62571-86-2carrierother/unknown16469467 8216349 9040098 15093593
    Diflunisal-- 22494-42-4carrier--17132209 11673972 7371361 2751413
    DigitoxinDigitoksin (see all 3)71-63-6carrier--11678517 10774625 10604823 10202961
    Ethacrynic acidEtacrinic acid (see all 6)58-54-8carrier--9275312 3714803 9863950 2792351
    Gadobenate Dimeglumine-- 113662-23-0carrierbinder9055236 16118549 11752352 9406019
    Gadofosveset trisodiumAblavar (see all 4)193901-90-5carriersubstrate16706555 19222207 17625839 17650553

    Selected Novoseek inferred chemical compound relationships for ALB gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 90.6 3964 10727680 (8), 8831085 (7), 9080259 (7), 17405790 (7) (see all 99)
    fibrinogen 83.7 1545 16703327 (7), 9610611 (7), 11422756 (7), 12969171 (7) (see all 99)
    cholesterol 79.9 2000 15082432 (7), 8524502 (6), 18563300 (6), 17279492 (5) (see all 99)
    rhsa 78.5 72 9167443 (2), 10502345 (2), 18199895 (2), 9688461 (2) (see all 38)
    dansylsarcosine 78.2 30 1382424 (6), 9430764 (3), 8720306 (2), 1706921 (2) (see all 16)
    urea 77.8 659 8366899 (5), 8573919 (4), 17361319 (4), 10666933 (4) (see all 99)
    uric acid 76.4 495 10910618 (5), 10898045 (4), 18442624 (4), 16554340 (3) (see all 99)
    hydroxyethyl starch 76.4 487 10703679 (8), 11515893 (7), 9261899 (6), 10361869 (6) (see all 99)
    glucose 73.8 1576 19349048 (6), 9103700 (6), 8575721 (6), 16920285 (5) (see all 99)
    fructosamine 71.2 212 10326628 (7), 1597333 (5), 8893144 (5), 8502341 (5) (see all 95)



    ALB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ALB gene: 
    NM_000477.5  

    Unigene Clusters for ALB:

    Albumin
    Hs.418167  [show with all ESTs], Hs.592379  [show with all ESTs]
    Unigene Representative Sequences: NM_000477, BX436222
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441319 ENST00000295897(uc003hgs.4 uc011cbe.2 uc003hgw.4 uc011cbf.2)
    ENST00000510166 ENST00000515133 ENST00000415165 ENST00000514786 ENST00000476441
    ENST00000503124 ENST00000509063 ENST00000401494 ENST00000505649 ENST00000511370
    ENST00000507673 ENST00000484992 ENST00000504043 ENST00000486939 ENST00000508932
    ENST00000495173
    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate ALB
    SwitchGear 3'UTR luciferase reporter plasmidALB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ALB
    Clone
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    OriGene ORF clones in mouse, rat for ALB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALB (NM_000477)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALB
    Primer
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    OriGene qPCR primer pairs and template standards for ALB
    OriGene qSTAR qPCR primer pairs in human, mouse for ALB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALB
      QuantiTect SYBR Green Assays in human, mouse, rat ALB
      QuantiFast Probe-based Assays in human, mouse, rat ALB

    Additional mRNA sequence: X51365.1 

    Selected DOTS entries (see all 209):

    DT.100864734  DT.98132054  DT.95377482  DT.100746389  DT.87011119  DT.100861910  DT.100746447  DT.100746541 
    DT.91816166  DT.95377906  DT.95376610  DT.100746432  DT.95376706  DT.100844172  DT.95376678  DT.100861974 
    DT.100746557  DT.100746613  DT.95376631  DT.91998425  DT.92056056  DT.98132061  DT.100746529  DT.95376639 

    3197 AceView cDNA sequences (see top 24):

    CB154702 T73709 BX463249 BX496355 AV718020 BX448763 T64294 AL531120 
    CR601390 BX422186 BG618609 CR607762 AL531299 BX422283 CR593838 AL558034 
    AL531579 BX382948 BX494684 BX340572 BX445210 BX494860 AI207701 BX462983 
    BG564126 Z20536 T64300 AL558093 CR603842 BG617320 BG566581 AI065100 
    CB154318 D17029 CR601553 AU120196 CR606332 CB113367 BX496334 BX445212 
    BX346202 BX422456 BU162704 AI114530 AL557771 AL531048 AA878749 BG566650 
    AA343688 CR612869 AU121150 AV693204 AI061645 AL532055 CR606436 AL564293 
    BX499263 CR615080 AU120497 CB153817 T40118 T73749 CB154342 BX498822 
    BX361690 BG569552 BX495682 CB147220 AU120504 BX447958 CB154103 CR618745 
    BX646865 BX340561 BG569183 AI133304 CR605103 CR624085 AU121313 BX427558 
    CR599721 BX448746 AI110757 BG565036 AL531415 R29455 CR617086 BX951535 
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    AI174852 BX497529 BX643363 BX448359 BX498042 BX494532 BX499259 BG618062 
    BG617889 AI064979 BX448026 BX506695 BX494681 AV687948 W20178 BQ064577 
    BX643444 BX495011 BX497107 AI114478 BX495407 BG564978 BG545171 BX423727 
    BG618534 BG565610 AV683057 BX494875 BC041789 AV689135 BG564470 AA333704 
    BG566032 D11536 BG564539 BG533551 BG564841 BX506480 AI913748 BX496816 
    AA313192 BX496526 BG569083 BX494610 BG569261 AI065087 CB147350 BG545043 
    BG564388 BX478761 BG563340 BX406148 AU121201 AI064826 CB123002 BX506608 
    BX494613 BX496691 BG568743 AW950619 BX494756 CB117054 BX643339 BX494406 
    AV689242 BX494757 BG618890 AL531119 BG533510 BX495156 BG565700 CB154275 
    BX406665 AV692621 BG568127 AA342690 BG617829 BX498293 CB122953 BX643406 
    BX955282 D11603 BX448171 BG562576 AA334461 BG568277 BX494642 AL564326 
    BX405474 BX498002 N64454 CB148280 BX509042 AI133647 BG564947 BX494895 
    BX346156 BG618315 BG617192 BG562968 AF075298 BG568231 BG567682 BX494704 
    BX643464 BG568664 BX494846 BX478675 BX448804 T69561 BG617737 CB130114 
    CB154711 BX643332 AL580413 AI114840 BG533262 CB148253 BX494702 BG569336 
    AV709846 R29351 BG562711 CB148267 BG565848 BX448579 AI133214 BX426997 
    BG567414 BG618471 BX346118 CB148260 CB162153 R29086 BX494654 BX506448 
    BX444015 AV681940 BG618717 AL532071 BX506453 CB138260 AV683628 BX495737 
    BG567415 BG565496 BG566104 AV693579 BX497301 BX495978 BX494789 BF195866 
    CB144748 AI963890 T58857 BX506637 AW779711 AL558012 AI913646 AA334661 
    BX494617 AI150977 CB148975 BG617092 BX427745 BQ646699 BG616720 AL532008 
    BG562770 BX494795 BG618872 BX494491 BX448005 BX346139 AV694019 BX506596 
    BG545232 AV696784 BX494468 BG533362 BX494585 BG564783 BX426948 AL531817 
    BX499111 BX423838 AI207675 BX506425 CB154107 BG563498 BG567266 BX367014 
    CB116998 BG617939 BX494935 AV691395 AA343347 CB124840 CB115646 BG618122 
    BX643460 AV690673 AA334232 H62140 BX506657 AI133654 BG568668 AV689405 
    AF075308 BG618605 AL532229 T68650 BX502662 BG566259 AA343592 BX494552 
    AW025528 CB147157 BG566084 BG618858 BX495483 BX494662 BG562867 AA333988 
    BG618354 BX509038 AA337556 BX497093 BX646885 BG565327 BG618140 BX494700 
    R28763 AV696577 BX494767 CB148248 BG566977 T95338 AA334608 BG616503 
    BX951485 AV686442 T68347 AY728024 AI061612 BG568126 BX427459 BG568609 
    BX506598 BX382958 CB142763 T39917 BX495658 T58867 CB141768 BX427638 
    BX494858 BX496899 BX496749 BX494362 BX495449 BX427967 BE326964 BX494821 
    BG562773 BX509071 AV694095 BX498990 BX506419 BX448017 BG568569 AI373076 
    AL531140 AL557799 BG564159 R29100 AW771519 AA343156 AV684346 AL557948 
    BX506550 BG618205 CB120380 BG616721 BG567568 BG568638 BX405713 BM919804 
    BX506990 BG617106 BX503378 BX346080 BX505588 BG568121 T39931 AV688146 
    AV717963 BX427135 AV684815 AV681846 BX955702 CB121452 BG533370 BG616893 
    BX498977 CB142753 T53287 BX496267 BX427047 BX499106 BG562447 BX497219 
    BG617963 BG569673 BX643293 BG533500 CB111931 CB114871 AL564622 BX496838 
    BG545080 BX494878 AV691266 T68284 BX373894 AV684190 BX405431 BG617949 
    CB158488 T39998 AI114679 AV689721 BG567916 T40103 BX494793 BG562829 
    BX494889 CB141205 BG618102 BG618272 CD608581 BG566641 BX427905 BG566795 
    BX507397 CB115655 AI133098 BG569108 BX478569 BG566383 BG618020 AI064701 
    AI635538 BG563955 AI133090 CB115376 W02621 BG565324 BX506615 BX494837 
    BG562717 BG562945 BX506656 BX463015 BX346017 AI110799 BX494489 BX495923 
    AV694744 BX955700 CB122280 AU120615 BG568327 BX494576 BG617108 BX497633 
    BX494867 AI190374 BX495801 T40972 T60491 BX448751 BG569130 BG568125 
    BG564616 BX494635 BX646224 BX346157 BX498302 BF105265 BG568321 BG568152 
    BG562691 BG569149 BX951491 BX494396 BM172031 BG564777 AU120138 BG568759 
    BX494799 BX494554 BG616972 BG564955 BX494364 BG567787 BX406749 BG617863 
    BX405616 BX494465 AI110671 BX951471 BX496849 BX498015 BX346053 AV687061 
    BX495643 T67814 BX509069 CB120379 BX427976 BX951529 AU120701 AV698085 
    AI110704 BX494845 BX346203 AU120831 BG617994 AL564759 AA334255 BG564634 
    AA333828 BG616951 BX643324 BG565123 BG617942 BG567807 CB141701 BX494820 
    BG564370 CB158427 CB154339 BX494955 BX325218 AV693872 BX427133 AA343023 
    BG618105 BX495216 BX509034 BX494703 BX505489 BX500990 AI337801 BX506723 
    BX494472 CB141769 BX448670 BG617149 BG617245 CB153374 BX497195 H47634 
    AV687241 AV690725 AI207490 AI613071 AV687092 BX505618 T53194 AV695875 
    CB146957 BX509081 AW051713 AV698176 BG569093 BX506415 BX448306 BG569259 
    CB153868 AA732830 CB114888 BX495391 BG533422 AA342578 BG564014 BG568293 
    AL531135 R28825 CB122997 AI114468 BG566495 BG616687 BX346016 BX494723 
    AA345784 AV688136 BX494488 AL557929 BX495015 BX494458 BX406402 BG545285 
    BG562524 T58192 BG618960 BX388044 AI765970 BG617810 BX506440 BX951452 
    BG567214 BI764872 BX447935 BX494608 AL531253 AA344644 CB154709 BX496840 
    AV684140 BX496738 BX478154 T67405 AU121284 AU121038 AV696218 BG564940 
    BG617088 BG567978 CB158433 BG617753 BX505362 BG564589 BX496067 AL557788 
    T39896 AA360370 BX406261 CB154286 BG616596 BX951517 BX427794 BX497184 
    BX494432 BX497467 BX406290 AI133263 BG568409 BX464255 BG562402 T40040 
    AV692942 BG616920 BG567129 BX406550 T61120 BG617589 AV685365 BX463206 
    R09237 AL531139 T40938 BE465170 CB122972 CB142722 BG567141 AI174724 
    BX496991 BX494800 BX495006 BG617079 AV691830 BG618090 CB116643 AI207432 
    D11839 BX509054 BX496410 CB115402 CB111966 BX494583 BX346081 AV683006 
    BG568931 BX507361 BX495035 AV681550 BG563896 AF074648 BG569340 BX495384 
    CB116974 BG567752 AV682048 BX506492 AI097221 BX406775 AV698487 BX494943 
    BV202313 AI613084 BX494746 N74333 T55693 AV686712 BG569159 BX646896 
    AL532203 BX496423 CB144713 BG568707 CB148294 AI064926 N80495 BX494672 
    BX422297 BX464212 BG568727 BG562594 BG617053 CB147260 AL532003 BX427687 
    AI140227 BX406782 AV690799 BG564534 BX494559 BG533390 BG567011 AV692452 
    BX495034 AA788868 BG616619 BX422386 AA343257 BX422310 BX494912 BX406528 
    BX494653 BX497079 BX507323 BX494869 BG565546 AV687353 BG617736 CB135755 
    BX494772 BX494718 CB149004 AV686090 BG565029 BX509085 BX496356 AA342898 
    AV685390 BX951514 BG567871 BV199990 BG564890 BG563858 AA313174 AW027940 
    CB146627 AI133207 BG562925 BX495026 BX497260 BX346224 BX367178 BG533527 
    AV695303 BG567103 CB147223 BX507360 BX497021 BX494740 BX646799 BG569637 
    T40946 AL565686 BX445314 AI174710 BX405340 BG569040 BX494918 AI628079 
    AA343350 BX495371 AL580423 AA342878 BX494402 CB158465 AV685305 BG569110 
    AV682304 BX496539 CB162698 BX494386 BG562736 BX382945 BG567991 BX494916 
    BG617545 T40045 BG562871 AL564448 AL532040 BX503452 BX494905 BX494461 
    BX406311 CB154358 BX494978 BX448299 BG563669 BX494436 BG564980 BX494516 
    BG568234 BX448107 BX405730 BG567447 BX505490 CB113322 BG565234 BX495023 
    T24032 BX951523 BG562588 BX325034 BG568977 AV682667 AI132936 AI133345 
    BX496736 CB113353 BX463245 CB116969 BX494530 BX494715 AI444620 BF126547 
    BG562547 BX509041 BG563201 BG533261 BX494442 BX509045 BX496768 BX494930 
    BX509061 BG563524 BQ643982 BG533566 BG568489 AI671745 R09733 BX494838 
    BG568416 BG563158 AV682805 AI985002 CB120365 BX494523 AI133118 AV691565 
    BX643355 T40032 AV687308 BG567983 AV684727 CB147244 T41051 BX494902 
    BX646894 BG567834 BX507374 AI061615 BG562715 BX494558 CB124855 AI140200 
    BG567408 BG569605 BX499075 BG566779 BX445315 BX494553 CB138256 AL563996 
    BG565237 BG563255 AV683679 BG564299 CB114886 BG564874 BX494752 BX497214 
    CB148976 BX498264 BX494452 CB115675 BX495855 BX643391 BX462967 AA334140 
    AI766232 BG568869 BX448374 BX509035 CB139145 BG569404 BG617883 BX325194 
    AV695169 BX509023 T40000 BX494990 AI313176 CB121432 BG562693 AV694470 
    AV698913 BG533534 BX494524 BX427151 BX496545 BG562531 CB116940 BG562949 
    BX346044 AV681806 BG618750 N57903 AI133671 AL564324 CB117052 AI064838 
    AI133120 BG567223 BX494531 BG564957 BG568812 BG568195 AI133473 BX643443 
    CB148967 AL563958 BG568788 BG618546 BG618453 BX427105 BG567629 BX427795 
    BG566335 BX951494 BX448898 AW242644 BX427060 BX506592 BG545166 AI110741 
    BX495441 AI949897 D11557 D11897 BX406372 BX506420 BX449082 BX495020 
    CB153814 AV688874 BX503393 CB154305 BG617214 BG568502 BG564508 BX495553 
    BX494550 CB116663 AV682396 BG566425 AV689241 BX951487 BX496259 AI132977 
    BG569690 AI207568 BX494577 AL579827 BG568353 BX427597 BG616988 BX405506 
    CB137774 BX494954 BX494685 BG401649 BG565918 CB154111 CB162427 BX643432 
    BX367025 BG616518 AL531382 BG562422 BX388080 AI110779 BX494540 BG569283 
    BX449067 BX497022 BG617879 AA342279 AV687060 BX646858 CB154694 BX406425 
    AI913643 CB115357 BX478566 BX951457 T50776 CB148232 BX406746 BG617480 
    BX951498 BG563528 BG562650 BX427018 BG565048 BX509063 BX405631 T39835 
    AL531055 AV681899 AI207652 AI480100 BG618610 AA342362 AL531947 BX367092 
    BX448101 BX494851 BX951480 BX494686 AV688476 BG562863 AU120923 BX406490 
    BG565778 AA342692 AA342371 BG618071 BX495515 BX505463 BG565646 BX346119 
    BG618823 BX426916 BG567035 BX325175 BX448216 AV699248 BX496800 BG616850 
    AU120135 BX426808 AV684724 BX494679 BG568009 BG565449 AV651382 CB147185 
    BG563718 BX494606 BX506412 BM926765 BG568242 BG568141 AV689263 BX496666 
    AA342131 BX494630 AL564422 BG564278 R01842 BX646839 AV687549 T40012 
    AI110809 BX478794 BX494815 AA343367 BX427997 BX495440 T84124 AI133063 
    AV691346 BG567304 AV691486 BG567464 AI373319 AL531616 BG567421 AL531673 
    BG569436 BX444164 AI133525 BX496182 BX448210 BX494972 BG563273 CB114872 
    BX494616 BX367187 BG566796 AI312891 AI064778 BX346198 T39927 T40907 
    BX498469 BG565639 BG565011 AL563998 AU118934 BG563708 BX494515 AI065042 
    AI064736 AA334527 CB153783 AF063579 BG562977 AI133622 BX506704 BX448987 
    BX507329 BG563726 BX426762 BX509067 BG564568 BX496171 BX956278 AI064758 
    BX506447 BX495721 T24081 AF074686 BG567386 BG618095 BG567423 CB113363 
    BG567225 BG563700 BG616735 BG564047 BG562589 BX494950 AV698586 AL557950 
    CB153800 BX494942 BX427210 AI065049 BG565405 BX506532 BX497175 BX346074 
    BG566428 CB153885 BG616725 BF196465 AI114590 T58858 BX509079 BG565136 
    BX506417 BX494355 BG545051 BG564265 BG567422 BX494804 BX346223 AL564582 
    AL564275 BG564703 T41004 BG568466 AI174821 BX494917 BX405824 AI478817 
    BX406675 AI133272 AA344424 AA344219 BX509060 BG565517 T39739 AL564312 
    BX494392 BG562861 AV690477 AA342401 BX506562 AA936693 BX494886 BX643462 
    BX506690 BG563658 BG569491 BG564377 BX447937 AV696099 AV686894 CB122306 
    BG545183 BG566478 BF740008 BX494473 AL580415 BX494805 BX506424 T40926 
    BX497150 BG566683 AV691680 BX499187 CB148259 BG564846 AI478644 BX346128 
    BG568934 BX951451 BM172063 BX509025 CB122251 T40876 BX494683 BG567926 
    AA343431 BX496975 BX463028 BX405657 BX956610 AL557960 BG533360 BX494467 
    BG562959 BG568095 BG567039 BG564149 BX643338 BG563343 BG567253 BQ652594 
    AI114666 CB141743 BX495004 AV696757 BG618716 AI207501 BG618602 BX494412 
    BX346050 AI110629 AV682640 BX507372 AV681691 BX497248 AI110619 BX494440 
    BG617293 T40962 CB154141 BG568704 BX426661 BG618240 BX643354 BX494786 
    AI133726 BX367162 BG562788 AI203974 AL532234 AV682076 AL580001 BF126542 
    BG565840 AA334810 BX494459 BG533414 BX423835 AV686400 BM721034 CB154295 
    BX646882 AV692658 BX643424 AV691598 AV688292 CB154134 BG568699 AL564714 
    BX494597 BX499134 AL557966 BG567245 AU120645 AI336158 BX497194 AI114710 
    AV685207 BX367169 BG533413 AV695883 CB141196 AV685417 BG567092 BX494451 
    BX643416 BG617940 AL532187 BX494578 BG533547 AV681931 BX494952 AV696219 
    AV695330 BX494819 BG569523 BG569505 AI823481 BX498083 BX427621 BX478860 
    BX365466 BX388009 BG565375 BC034026 BX478716 BG618293 CB153867 CB147219 
    BX498093 BE326887 BX497039 BX494872 T53977 BG563897 BG617971 BG545366 
    BX494582 CB142735 BX497547 BG563883 BX494900 BG568063 BG565085 BX497210 
    BG562651 BX494426 BX506418 AI133100 BX494573 BG567352 BX498115 BX506638 
    BX494741 BX405709 AI652144 BX951532 BX449015 BG566403 BX505611 BX956653 
    BX426711 BG565376 BX951515 BG617980 BX497121 AV681715 BX496920 BX405738 
    CB114910 BX497624 AV696503 BX506423 AF063503 AA334670 BX448140 BX405760 
    BG567812 BX498839 BG569188 BG617591 AA334306 BX506410 AL558064 BG565490 
    BG617692 BX406759 CB154300 AW300438 BG566839 CB117009 BG562906 AV697409 
    BG618377 BG617359 BG616943 T55956 BG565446 AV691025 BX494474 BX506565 
    BX497111 BG563555 CB134868 BG618464 N93851 BX509072 AA313523 BG567169 
    CB113368 AA342121 BG617416 BX406679 BG616949 AL531074 BX494650 BG564904 
    BX494769 BX494569 BX494490 BG564704 AL564251 BX494721 BG533321 BX497012 
    CB111915 AV694156 BG533267 BX427064 AL579895 BX496572 T68296 AA341961 
    AL579783 T40880 AL579840 AL564286 AA342736 AL580418 AV694522 AL563932 
    AA948088 AL563961 T61879 AA342230 AL564067 AL564121 AL579975 H72085 
    T40716 AL580002 AV691912 AL579720 AL564073 T40882 AL564047 T74681 
    T40970 AL580408 AL532186 AV688139 T40749 N76438 AL564313 AA342398 
    AL564323 BX426979 T56825 W05241 AA343950 AL564018 AL579777 T67485 
    T95428 AL564029 AL564320 AL579999 BX506617 AI174713 R28744 AL579785 
    AL579786 AV693412 AL563968 BG568492 AV685668 AL564260 T55237 T48227 
    AL564325 AV694172 T40047 T61291 AL563957 BX448194 BX325118 AV695837 
    AV686013 AV685329 AV696991 BG533570 BX494657 AL564328 H90143 AV689797 
    AA343176 AV684709 AL564102 T58966 AL579789 AL564044 AL579792 AL579990 
    T74880 AL580427 BM171974 T64684 T58917 H90242 W65337 AV695935 
    AL564734 T60361 T71779 AL563948 H47938 T61286 T40952 AL563981 
    AL579941 T69631 AL580422 AL579939 AL564267 AL580007 AV693556 T60576 
    AL580419 AL564701 AL564163 T57381 AL564256 T68695 AL564562 R09734 
    T67566 H71319 AL563923 BM172086 AL579880 AL564264 T64672 AL579797 
    T57320 W40324 T61713 R09351 BG566727 AL564509 AL564156 AL564178 
    T61335 T57203 H71366 AL579933 T72884 T69627 AL564194 T73776 
    AL564288 T74548 T74936 AL564195 AL564198 T48228 AL564090 BG533491 
    AL564304 AL563984 R06692 T71739 AL564177 AL564223 BG545099 T61233 
    T62153 AL564193 AL564245 AL564165 AL580428 T51173 AL564115 AL579870 
    AL564183 AL564248 T58916 BM172081 R98207 AL579885 T68361 AL563926 
    T60978 T51681 T89358 AL579766 AL579891 AL564064 R01843 T70454 
    T67964 AL579938 AL564179 T53288 AL579854 T81874 T58905 T53918 
    W35144 T50808 T53195 AL564164 T50938 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ALB (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a ·
    SP1:                                                              -                             -                       -                                       
    SP2:                                                  -     -     -     -     -     -     -     -     -     -           -                                       
    SP3:                    -     -     -     -     -     -     -     -     -     -                 -                       -                                       
    SP4:                          -     -     -     -     -     -     -     -     -     -           -                       -                                       
    SP5:                                      -     -     -     -     -     -                       -                                                               

    ExUns: 14b ^ 15 ^ 16a · 16b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ALB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ALB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATAAGAG
    ALB Expression
    About this image


    ALB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 21 entries
             Mature Hepatocytes Liver Lobule
             Adult liver progenitor cells
             Immature hepatocytes
             Human Hepatocyte (HH)   
     
     Epithelial Cells
             Hepatic Endoderm Cells Ventral Foregut Endoderm
     
     Gut Tube (Gastrointestinal Tract)
             Hepatic Endoderm Cells Ventral Foregut Endoderm
     
     Blood (Cardiovascular System)
             Fetal Liver CD34+ Cells   
     
     Pancreas (Endocrine System)
             Endocrine progenitors
    ALB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALB Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.418167 Hs.592379

    UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
    Tissue specificity: Plasma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ALB: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Oxidative Stress in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ALB
    OriGene qSTAR qPCR primer pairs in human, mouse for ALB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALB
    QuantiTect SYBR Green Assays in human, mouse, rat ALB
    QuantiFast Probe-based Assays in human, mouse, rat ALB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ALB gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alb1 , 5 albumin1, 5 77.08(n)1
    72.37(a)1
      5 (44.70 cM)5
    116571  NM_009654.31  NP_033784.21 
     904608895 
    chicken
    (Gallus gallus)
    Aves ALB1 albumin 60.37(n)
    47.95(a)
      396197  NM_205261.1  NP_990592.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cars21 cysteinyl-tRNA synthetase 2, mitochondrial (putative) 54.04(n)
    39.87(a)
      448227  NM_001004887.2  NP_001004887.2 


    ENSEMBL Gene Tree for ALB (if available)
    TreeFam Gene Tree for ALB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ALB gene
    AFM2  GC2  AFP2  
    2 SIMAP similar genes for ALB using alignment to 8 protein entries:     ALBU_HUMAN (see all proteins):
    AFP    AFM

    ALB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ALBU_HUMAN, P02768: A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic
    augmentation of zinc concentration in the blood. The sequence shown is that of variant albumin A


    Selected SNPs for ALB (see all 598)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0130114
    Dysalbuminemic hyperthyroxinemia (DH)4--see VAR_0130112 L P mis40--------
    VAR_0005144
    Dysalbuminemic hyperthyroxinemia (DH)4--see VAR_0005142 R H mis40--------
    VAR_0130134
    Dysalbuminemic hyperthyroxinemia (DH)4--see VAR_0130132 R P mis40--------
    rs774081631,2
    Cpathogenic174148127(+) TGCACA/GTAAGA 1 -- spd10--------
    rs778923781,2
    Cpathogenic174150480(+) ATCACC/TTGTAA 2 P L mis10--------
    rs773353741,2
    Cpathogenic174155714(+) TTTTTA/G/TGGGCA 1 -- spa11CSA 1
    rs750026281,2
    Cpathogenic174155727(+) AGCTCA/C/GCCTGA 3 H P R mis10--------
    rs792280411,2
    Cpathogenic174163355(+) TTGCCA/GAGGAG 2 K E mis10--------
    rs762420871,2
    Cuntested174157309(+) TAAGGA/G/TTGTTT 3 D G V mis10--------
    rs782840521,2,,4
    C,Funtested174163244(+) AGCTCG/ATGAAA 2 /M /V mis11Minor allele frequency- A:0.00NA 4548

    HapMap Linkage Disequilibrium report for ALB (74262831 - 74287129 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ALB:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv956e199CNV Deletion23128226
    esv274665CNV Insertion20981092
    nsv879491CNV Loss21882294
    nsv879490CNV Gain21882294

    Human Gene Mutation Database (HGMD): ALB
    Locus Specific Mutation Databases (LSDB): ALB

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ALB
    DNA2.0 Custom Variant and Variant Library Synthesis for ALB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 103600   
    OMIM disorders: 194470  
    UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
  • Dysalbuminemic hyperthyroxinemia (DH) [MIM:103600]: A disorder characterized by abnormally elevated
    levels of total serum thyroxine (T4) in euthyroid patients. It is due to abnormal serum albumin that binds T4
    with enhanced affinity. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for ALB (see all 504):    
    About MalaCards
    hepatorenal syndrome    systemic capillary leak syndrome    analbuminemia    bilateral choanal atresia
    blastomycosis    kallikrein hypertension    immunotactoid glomerulopathy    dysalbuminemic hyperthyroxinemia
    congenital analbuminemia    hepatopulmonary syndrome    peptic ulcer perforation    hypertensive retinopathy
    hyperthyroxinemia    tricuspid atresia    acute generalized exanthematous pustulosis    apo a-i deficiency
    chylous ascites    protein-losing enteropathy    perinephritis    cap polyposis

    Selected diseases from the University of Copenhagen DISEASES database for ALB (see all 69):
    Diabetes mellitus     Proteinuria     Liver disease     Kidney failure
    Hypertension     Nephrotic syndrome     Lung disease     Nephritis
    Peritonitis     protein-energy malnutrition     protein-losing enteropathy     Hepatocellular carcinoma
    Heart disease     Anemia     Hepatitis B     Cerebrovascular accident
    Kernicterus     Hypersensitivity reaction type II disease     Peripheral vascular disease     Atherosclerosis

    ALB for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ALB gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    microalbuminuria 94.9 1034 7634745 (5), 9759691 (5), 15717883 (5), 12788992 (4) (see all 99)
    albuminuria 92.5 360 16703327 (5), 17405790 (5), 10489399 (4), 9179466 (4) (see all 99)
    hypoalbuminemia 90.4 275 1569418 (4), 19615208 (4), 9397418 (4), 10428270 (3) (see all 99)
    diabetic nephropathies 89.2 362 1881577 (4), 8264568 (3), 11131103 (3), 10198605 (3) (see all 99)
    renal disease 87 640 8163055 (4), 8593760 (4), 19729498 (3), 17928473 (3) (see all 99)
    proteinuria 86.2 625 12521234 (5), 9915226 (5), 16425574 (5), 1831839 (5) (see all 99)
    malnutrition 86 406 17957127 (4), 19218044 (4), 11592443 (3), 17321950 (3) (see all 99)
    renal failure chronic 80.6 103 2082760 (2), 1951474 (2), 9101098 (2), 1282889 (1) (see all 98)
    nephrotic syndrome 79.7 186 2082057 (6), 8502517 (5), 1379421 (3), 15481604 (3) (see all 99)
    protein-energy malnutrition 76.8 30 10219494 (2), 15695952 (2), 9106105 (1), 10433138 (1) (see all 24)

    Genetic Association Database (GAD): ALB
    Human Genome Epidemiology (HuGE) Navigator: ALB (17 documents)

    Export disorders for ALB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ALB gene, integrated from 10 sources (see all 8844):
    (articles sorted by number of sources associating them with ALB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids. (PubMed id 11743713)1, 2, 7 Petitpas I.... Curry S. (J. Mol. Biol. 2001)
    2. Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. (PubMed id 7852505)1, 2, 9 Rushbrook J.I.... Divino C.M. (J. Clin. Endocrinol. Metab. 1995)
    3. A nucleotide insertion and frameshift cause albumin Kenitra, an extended and O-glycosylated mutant of human serum albumin with two additional disulfide bridges. (PubMed id 11168369)1, 2, 9 Minchiotti L....Galliano M. (Eur. J. Biochem. 2001)
    4. Crystal structure of human serum albumin at 2.5-A resolution. (PubMed id 10388840)1, 2, 9 Sugio S.... Kobayashi K. (Protein Eng. 1999)
    5. Protein and DNA sequence analysis of a 'private' genetic variant: albumin Ortonovo (Glu-505-->Lys). (PubMed id 7902134)1, 2, 9 Galliano M.... Putnam F.W. (Biochim. Biophys. Acta 1993)
    6. Two alloalbumins with identical electrophoretic mobility are produced by differently charged amino acid substitutions. (PubMed id 1347703)1, 2, 9 Minchiotti L.... Porta F. (Biochim. Biophys. Acta 1992)
    7. Genetic variants of serum albumin in Americans and Japanese. (PubMed id 1946412)1, 2, 9 Madison J.... Putnam F.W. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    8. Allostery in a monomeric protein: the case of human serum albumin. (PubMed id 20346571)1, 7 Ascenzi P. and Fasano M. (Biophys. Chem. 2010)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders