ALAS1 Gene

Aliases
for ALAS1 gene

Previous GC identifers: GC03P051324 GC03P051484 GC03P052088 GC03P052190

Summaries
for ALAS1 gene

Genomic Views
for ALAS1 gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_022517.18  

SwitchGear Promoter luciferase reporter plasmid: ALAS1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALAS1

ALAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P052207:  view genomic region     (about GC identifiers)

Proteins
for ALAS1 gene

Explore the universe of human proteins at neXtProt for ALAS1: NX_P13196

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): ALAS1 OriGene Custom Protein Services for ALAS1
	GenScript Custom Purified and Recombinant Proteins Services for ALAS1
	Novus Biologicals ALAS1 Protein Novus Biologicals ALAS1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ALAS1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ALAS1
	GenScript Custom Superior Antibodies Services for ALAS1
	Novus Biologicals ALAS1 Antibodies
	Abcam antibodies for ALAS1
	Uscn Antibodies for ALAS1
	ThermoFisher Antibodies for ALAS1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ALAS1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ALAS1

Protein Domains /
Families
for ALAS1 gene

ProtoNet protein and cluster: P13196

Function
for ALAS1 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ALAS1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALAS1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ALAS1
		SwitchGear 3'UTR luciferase reporter plasmid: ALAS1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALAS1 (see all 7) OriGene shRNA RFP: ALAS1 OriGene siRNA: ALAS1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALAS1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ALAS1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALAS1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALAS1 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ALAS1 (NM_000688)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALAS1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALAS1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ALAS1
		Search LifeMap BioReagents cell lines for ALAS1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALAS1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Alas1)

Pathways & Interactions
for ALAS1 gene

	Super-pathway	contained gene-specific pathways
1	heme biosynthesis II	heme biosynthesis II 1.00 tetrapyrrole biosynthesis II 0.57 Heme biosynthesis 0.78 Metabolism of porphyrins 0.50 Heme Biosynthesis 0.78
2	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 1.00 Fatty acid, triacylglycerol, and ketone body metabolism 0.52 PPARA Activates Gene Expression 0.74
3	Metabolism	Metabolism 1.00 Metabolism of lipids and lipoproteins 0.34 Metabolic pathways 0.38
4	Expression of ALAS1	Expression of ALAS1 1.00
5	FOXA2 and FOXA3 transcription factor networks	FOXA2 and FOXA3 transcription factor networks 1.00

4 BioSystems Pathways for ALAS1

	Heme Biosynthesis
	tetrapyrrole biosynthesis II
	FOXA2 and FOXA3 transcription factor networks
	heme biosynthesis II

5/8        Reactome Pathways for ALAS1

	Expression of ALAS1
	Heme biosynthesis
	Metabolism
	Fatty acid, triacylglycerol, and ketone body metabolism
	Metabolism of porphyrins

3         Kegg Pathways  (Kegg details for ALAS1)

	Glycine, serine and threonine metabolism
	Porphyrin and chlorophyll metabolism
	Metabolic pathways

ALAS1 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ALAS1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/42 Interacting proteins for ALAS1 (P13196^{2, 3} ENSP00000309259⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 42)

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for ALAS1 gene

Transcripts
for ALAS1 gene

Expression
for ALAS1 gene

ALAS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTCAATTA

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	TestisTestis Interstitium			Testis
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALAS1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALAS1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALAS1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALAS1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALAS1

Orthologs
for ALAS1 gene

Paralogs
for ALAS1 gene

Paralogs for ALAS1 gene

ALAS2²  GCAT²  

1 SIMAP similar gene for ALAS1 using alignment to 4 protein entries:     HEM1_HUMAN (see all proteins):

ALAS2

ALAS1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for ALAS1
PGOHUM00000239424

Genomic Variants
for ALAS1 gene

10/294 NCBI SNPs in ALAS1 are shown (see all 294)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1145456711,2		--	52230123(+)	AGTTGC/TTTACA	2	--	us2k1		0	--	--	--	--
rs1868705561,2		--	52230319(+)	CAAGCC/TTTGAA	2	--	us2k1		0	--	--	--	--
rs1049021,2	C,F,A,	--	52230440(+)	CCCCCA/CAAAAA	2	--	us2k1		3		NA WA	122
rs1049031,2	C,F,A,	--	52230475(+)	GCTCAA/TGCCTA	2	--	us2k1		9		NA WA EA	370
rs1917616701,2		--	52230509(+)	GAGGGC/TGATCA	2	--	us2k1		0	--	--	--	--
rs1473387251,2		--	52230641(+)	GAATCA/GCTTGA	2	--	us2k1		0	--	--	--	--
rs1487116571,2		--	52230669(+)	TGCAGC/TGAGCC	2	--	us2k1		0	--	--	--	--
rs1165357031,2	C,F,	--	52230786(+)	CAGGGA/TTTATG	2	--	us2k1		1		WA	118
rs600979541,2	C,,	--	52230799(+)	CCTATC/TGCCCA	2	--	us2k1		1		WA	2
rs1414334631,2		--	52230884(+)	CTTGGG/TTCCAA	2	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for ALAS1 (52232102 - 52248343 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ALAS1
     2 CNVs: 51113 4337

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALAS1

DNA2.0 Custom Variant and Variant Library Synthesis for ALAS1

Disorders / Diseases
for ALAS1 gene

20/24 diseases for ALAS1

5 Novoseek disease relationships for ALAS1 gene    About this table

Publications
for ALAS1 gene

PubMed articles for ALAS1 gene, integrated from 9 sources (see all 108) (see top 10): (articles sorted by number of sources associating them with ALAS1)

Utopia: connect your pdf to the dynamic world of online information

1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
2. Two different genes encode delta-aminolevulinate synthase in humans: nucleotide sequences of cDNAs for the housekeeping and erythroid genes. (PubMed id 2263504)^{1, 2} Bishop D.F. (1990)
3. Sequence of human 5-aminolevulinate synthase cDNA. (PubMed id 3671094)^{1, 2} Bawden M.J....Elliott W.H. (1987)
4. Human delta-aminolevulinate synthase: assignment of the housekeeping gene to 3p21 and the erythroid-specific gene to the X chromosome. (PubMed id 2347585)^{1, 9} Bishop D.F....Astrin K.H. (1990)
5. Conversion of 5-aminolevulinate synthase into a more active enzyme by linking the two subunits: spectroscopic and kinetic properties. (PubMed id 15840827)^{7, 9} Zhang J....Ferreira G.C. (2005)
6. Hepatic nuclear factor 3 and nuclear factor 1 regulate 5-aminolevulinate synthase gene expression and are involved in insulin repression. (PubMed id 15123725)^{1, 9} Scassa M.E....Canepa E.T. (2004)
7. Transient state kinetic investigation of 5-aminolevulinate synthase reaction mechanism. (PubMed id 12191993)^{7, 9} Zhang J. and Ferreira G.C. (2002)
8. Molecular regulation of 5-aminolevulinate synthase. Diseases related to heme biosynthesis. (PubMed id 2095458)^{1, 9} May B.K....Cox T.C. (1990)
9. Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibition. (PubMed id 16234850)^{1, 9} Abu-Farha M....Willmore W.G. (2005)
10. Inhibitory effect of AP-1 complex on 5-aminolevulinate synthase gene expression through sequestration of cAMP-response element protein (CRE)-binding protein (CBP) coactivator. (PubMed id 12433930)^{1, 9} Guberman A.S....Canepa E.T. (2003)
11. Alternative splicing and tissue-specific transcription of human and rodent ubiquitous 5-aminolevulinate synthase (ALAS1) genes. (PubMed id 11267664)^{1, 9} Roberts A.G. and Elder G.H. (2001)
12. Assignment of the human housekeeping delta-aminolevulinate synthase gene (ALAS1) to chromosome band 3p21.1 by PCR analysis of somatic cell hybrids. (PubMed id 7698013)^{1, 9} Cotter P.D....Bishop D.F. (1995)
13. Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin. (PubMed id 18719978)^{1, 9} Zheng J....Bonkovsky H.L. (2008)
14. Histidine 282 in 5-aminolevulinate synthase affects substrate binding and catalysis. (PubMed id 17469798)^{7, 9} Turbeville T.D....Ferreira G.C. (2007)
15. Repression of 5-aminolevulinate synthase gene by the potent tumor promoter, TPA, involves multiple signal transduction pathways. (PubMed id 15797241)^{1, 9} Guberman A.S....Canepa E.T. (2005)
16. An alternatively-spliced exon in the 5'-UTR of human ALAS1 mRNA inhibits translation and renders it resistant to haem-mediated decay. (PubMed id 15710391)^{1, 9} Roberts A.G....Llewellyn D.H. (2005)
17. Down-regulation of aminolevulinate synthase, the rate -limiting enzyme for heme biosynthesis in Alzheimer's disease. (PubMed id 19477221)^{1, 9} Dwyer B.E....Zhu X. (2009)
18. Increased heme oxygenase-1 and decreased delta-aminolevulinate synthase expression in the liver of patients with acute liver failure. (PubMed id 15547665)^{1, 9} Fujii H....Morita K. (2004)
19. Mechanism of 5-aminolevulinate synthase and the role of the protein environment in controlling the cofactor chemistry. (PubMed id 12699240)^{7, 9} Ferreira G.C. and Zhang J.S. (2002)
20. Nuclear receptor 5A (NR5A) family regulates 5-aminolev ulinic acid synthase 1 (ALAS1) gene expression in steroidogenic cells. (PubMed id 23024262)¹ Ju Y....Miyamoto K. (2012)
21. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
22. Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)¹ Sklar P....Purcell S.M. (2011)
23. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
24. Lon peptidase 1 (LONP1)-dependent breakdown of mitoch ondrial 5-aminolevulinic acid synthase protein by heme in human liver cells. (PubMed id 21659532)¹ Tian Q....Bonkovsky H.L. (2011)
25. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
26. Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)¹ Casabonne D....de Sanjose S. (2010)
27. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
28. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
29. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
30. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
31. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
32. Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PubMed id 17672918)¹ Szafranski K....Platzer M. (2007)
33. [Quantifying gene expression in prostate carcinoma. Which endogenous reference genes are suitable?] (PubMed id 17628775)¹ Jung M....Jung K. (2007)
34. A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)¹ Girard A....Carmell M.A. (2006)
35. A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. (PubMed id 16730941)¹ Tsang H.T.H....Sanderson C.M. (2006)
36. Cloning, expression, and characterization of 5-aminol evulinic acid synthase from Rhodopseudomonas palustris KUGB306. (PubMed id 15251194)⁷ Choi H.P....Sung H.C. (2004)
37. PCR isolation and cloning of novel splice variant mRNAs from known drug target genes. (PubMed id 15028279)¹ Jin P.... Stuve L.L. (2004)
38. Onset of X-linked sideroblastic anemia in the fourth decade. (PubMed id 15477213)¹ Cortesao E....Tamagnini G. (2004)
39. Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. (PubMed id 12878157)¹ Imabayashi H.... Umezawa A. (2003)
40. Multiple mechanisms for hereditary sideroblastic anemia. (PubMed id 11929048)¹ Furuyama K. and Sassa S. (2002)
41. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
42. Circular permutation of 5-aminolevulinate synthase as a tool to evaluate folding, structure and function. (PubMed id 11929042)¹ Ferreira G.C. and Cheltsov A.V. (2002)
43. The solution structure and heme binding of the presequence of murine 5-aminolevulinate synthase. (PubMed id 11566198)¹ Goodfellow B.J....Macedo A.L. (2001)
44. Regulation by heme of mitochondrial protein transport through a conserved amino acid motif. (PubMed id 8424176)¹ Lathrop J.T. and Timko M.P. (1993)
45. Elevation of delta-aminolevulinic acid synthase and cytochrome PB1 P450 messenger RNA levels by dihydropyridines, dihydroquinolines, sydnones, and N-ethylprotoporphyrin IX. (PubMed id 1859461)⁹ Mackie J.E....Marks G.S. (1991)
46. 5-Aminolevulinate synthase in sideroblastic anemias: mRNA and enzyme activity levels in bone marrow cells. (PubMed id 1415186)⁹ Bottomley S.S....May B.K. (1992)
47. Peroxisome proliferator-activated receptor alpha controls hepatic heme biosynthesis through ALAS1. (PubMed id 19289130)⁹ Degenhardt T....Carlberg C. (2009)
48. Zinc mesoporphyrin represses induced hepatic 5-aminolevulinic acid synthase and reduces heme oxygenase activity in a mouse model of acute hepatic porphyria. (PubMed id 11343251)⁹ Schuurmans M.M....Meyer U.A. (2001)
49. Alteration of mRNA levels of delta-aminolevulinic acid synthase, ferrochelatase and heme oxygenase-1 in griseofulvin induced protoporphyria mice. (PubMed id 10215191)⁹ Inafuku K....Nonaka S. (1999)
50. Regulation of human liver delta-aminolevulinic acid synthase by bile acids. (PubMed id 17975826)⁹ Peyer A.K....Meyer U.A. (2007)
51. Phosphatidylinositol 3-kinase and Ras/mitogen-activated protein kinase signaling pathways are required for the regulation of 5-aminolevulinate synthase gene expression by insulin. (PubMed id 11716532)⁹ Scassa M.E....Canepa E.T. (2001)
52. Superinduction by cycloheximide of cytochrome P4502H1 and 5-aminolevulinate synthase gene transcription in chick embryo liver. (PubMed id 7678728)⁹ Dogra S.C....May B.K. (1993)
53. Functional analysis of the 5' regulatory region of th e 5-aminolevulinate synthase (ALAS1) gene in response to estrogen. (PubMed id 19656447)⁹ du Plessis N....Warnich L. (2009)
54. Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans. (PubMed id 16121195)⁹ Astner I....Heinz D.W. (2005)
55. Identification of the xenosensors regulating human 5-aminolevulinate synthase. (PubMed id 15178759)⁹ Podvinec M....Meyer U.A. (2004)
56. Mechanism of the synergistic induction of CYP2H by isopentanol plus ethanol: comparison to glutethimide and relation to induction of 5-aminolevulinate synthase. (PubMed id 9851836)⁹ Louis C.A....Sinclair J.F. (1998)
57. The role of heme in gene expression. (PubMed id 8936331)⁹ Sassa S. and Nagai T. (1996)
58. Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA. (PubMed id 2050125)⁹ Cox T.C.... May B.K. (1991)
59. Heme as a magnificent molecule with multiple missions: heme determines its own fate and governs cellular homeostasis. (PubMed id 17785948)⁹ Furuyama K....Vargas P.D. (2007)
60. Gene expression studies in prostate cancer tissue: which reference gene should be selected for normalization? (PubMed id 16211407)⁹ Ohl F....Jung K. (2005)
61. Induction of 5-aminolevulinate synthase by drugs is independent of increased apocytochrome P450 synthesis. (PubMed id 8806606)⁹ Jover R....Meyer U.A. (1996)
62. The effect of short-time active listening training. (PubMed id 20168051)⁹ Tatsumi A....Sano Y. (2010)
63. (Far) Outside the box: genomic approach to acute porphyria. (PubMed id 17298222)⁹ Thunell S. (2006)
64. Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is disrupted in sideroblastic anemia. (PubMed id 10727444)⁹ Furuyama K. and Shigeru S. (2000)
65. Heme biosynthesis by the malarial parasite. Import of delta-aminolevulinate dehydrase from the host red cell. (PubMed id 9268315)⁹ Bonday Z.Q....Padmanaban G. (1997)
66. Molecular mechanism of heme biosynthesis. (PubMed id 9526800)⁹ Fujita H. (1997)
67. Control of hemoglobin synthesis in erythroid differentiating K562 cells. I. Role of iron in erythroid cell heme synthesis. (PubMed id 8645006)⁹ Kawasaki N....Hayakawa T. (1996)
68. [Molecular regulation of heme biosynthesis] (PubMed id 7616645)⁹ Fujita H....Takagawa M. (1995)
69. Reference gene selection for head and neck squamous c ell carcinoma gene expression studies. (PubMed id 19650912)⁹ Lallemant B....Brouillet J.P. (2009)
70. [Effectiveness of mental health training including ac tive listening for managers] (PubMed id 18552457)⁹ Ikegami K....Nagata S. (2008)
71. Effects of repeated administration with CP-55,940, a cannabinoid CB1 receptor agonist on the metabolism of the hepatic heme. (PubMed id 15896668)⁹ Fontanellas A....Enriquez de Salamanca R. (2005)
72. Examination of mitochondrial protein targeting of haem synthetic enzymes: in vivo identification of three functional haem-responsive motifs in 5-aminolaevulinate synthase. (PubMed id 15482256)⁹ Dailey T.A....Dailey H.A. (2005)
73. [Progress of study on sideroblastic anemia and its possible gene therapy--review] (PubMed id 15972158)⁹ Wang Y.Q. and Zhu P. (2005)
74. [Delta-aminolevulinate synthase (ALAS)] (PubMed id 15628518)⁹ Kondo M. (2004)
75. A study of the effects of active listening on listeni ng attitudes of middle managers. (PubMed id 14960831)⁹ Kubota S....Nagata S. (2004)
76. Reciprocal regulation of haem biosynthesis and the circadian clock in mammals. (PubMed id 15269772)⁹ Kaasik K. and Lee C.C. (2004)
77. 5-Aminolevulinic acid synthase: mechanism, mutations and medicine. (PubMed id 12686158)⁹ Shoolingin-Jordan P.M....Wang S.F. (2003)
78. Regulation of erythroid 5-aminolevulinate synthase expression during erythropoiesis. (PubMed id 10582344)⁹ Sadlon T.J....May B.K. (1999)
79. [X-linked sideroblastic anemia] (PubMed id 10483144)⁹ Muramatsu M....Urabe A. (1999)
80. [delta-Aminolevulinate synthase (ALAS)] (PubMed id 10543122)⁹ Kondo M. (1999)
81. [An infant case of sideroblastic anemia that responded to oral pyridoxine] (PubMed id 10496043)⁹ Kudo K....Kojima S. (1999)
82. X-linked sideroblastic anaemia due to a mutation in the erythroid 5-aminolaevulinate synthase gene leading to an arginine170 to leucine substitution. (PubMed id 9688293)⁹ Edgar A.J....Wickramasinghe S.N. (1998)
83. R411C mutation of the ALAS2 gene encodes a pyridoxine-responsive enzyme with low activity. (PubMed id 9858242)⁹ Furuyama K.... Yamamoto M. (1998)
84. Control of hemoglobin synthesis in erythroid differentiating K562 cells. II. Studies of iron mobilization in erythroid cells by high-performance liquid chromatography-electrochemical detection. (PubMed id 9521555)⁹ Kawasaki N....Hayakawa T. (1998)
85. Tissue-specific stability of nuclear- and mitochondrially encoded mRNAs. (PubMed id 8806759)⁹ Connor M.K....Hood D.A. (1996)
86. Molecular regulation--biological role of heme in hematopoiesis. (PubMed id 2032026)⁹ Abraham N.G. (1991)
87. Guide to drug porphyrogenicity prediction and drug prescription in the acute porphyrias. (PubMed id 17578481)⁹ Thunell S....Brun A. (2007)
88. Supervisors' attitudes and skills for active listenin g with regard to working conditions and psychological stress reactions among su bordinate workers. (PubMed id 17429164)⁹ Mineyama S....Kawakami N. (2007)
89. Identification and validation of suitable endogenous reference genes for gene expression studies of human bladder cancer. (PubMed id 16600798)⁹ Ohl F....Jung K. (2006)
90. Up-regulation of heme biosynthesis during differentiation of Neuro2a cells. (PubMed id 16567402)⁹ Shinjyo N. and Kita K. (2006)
91. On the selectivity of 5-aminolevulinic acid-induced protoporphyrin IX formation. (PubMed id 15134506)⁹ Collaud S....Lange N. (2004)
92. Enzymes for heme biosynthesis are found in both the mitochondrion and plastid of the malaria parasite Plasmodium falciparum. (PubMed id 15144063)⁹ Sato S....Wilson R.J. (2004)
93. [Hereditary sideroblastic anemia: a rare diagnosis] (PubMed id 15217771)⁹ Brahem-Jmili N....Kortas M. (2004)
94. Circular permutation of 5-aminolevulinate synthase: effect on folding, conformational stability, and structure. (PubMed id 12736261)⁹ Cheltsov A.V....Ferreira G.C. (2003)
95. Porphyrins, porphyrin metabolism and porphyrias. I. Update. (PubMed id 11202048)⁹ Thunell S. (2000)
96. Molecular aspects of the inherited porphyrias. (PubMed id 10692079)⁹ Sassa S. and Kappas A. (2000)
97. A novel mutation of the erythroid-specific delta-aminolaevulinate synthase gene in a patient with X-linked sideroblastic anaemia. (PubMed id 10444183)⁹ Harigae H....Sasaki T. (1999)
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