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ALAS1 Gene

protein-coding GIFtS: 59

GC03P052207

aminolevulinate, delta-, synthase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ALAS3, ALAS)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ALAS ^²
ALAS-H ^³
ALAS3 ^², ³
ALASH ^², ³
EC 2.3.1.37 ^³
MIG4 ^²

Descriptions
5-aminolevulinate synthase 1 ^²
5-aminolevulinic acid synthase ^³
Delta-ALA synthetase ^³
Delta-aminolevulinate synthase ^³
aminolevulinate, delta-, synthase 1 ^²
migration-inducing protein 4 ^²

External Ids
HGNC: 396¹
Entrez Gene: 211²
UniProtKB: P13196³
Ensembl: ENSG00000023330⁷

Search outside databases for aliases for ALAS1 gene

Previous GC identifers: GC03P051324 GC03P051484 GC03P052088 GC03P052190

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ALAS1:

Delta-aminolevulinate synthase (ALAS; EC 2.3.1.37) catalyzes the condensation of glycine with

succinyl-CoA to form delta-aminolevulinic acid. This nuclear-encoded mitochondrial enzyme is the

first and rate-limiting enzyme in the mammalian heme biosynthetic pathway. There are 2

tissue-specific isozymes: a housekeeping enzyme encoded by the ALAS1 gene and an erythroid

tissue-specific enzyme encoded by ALAS2 (MIM 301300).[supplied by OMIM]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALAS1 gene

Entrez Gene cytogenetic band: 3p21.1 Ensembl cytogenetic band: 3p21.1 HGNC cytogenetic band: 3p21

ALAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P052207: (about GC identifiers)

Start:	52,207,156 bp from pter
End:	52,223,383 bp from pter
Size:	16,228 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: HEM1_HUMAN, P13196 (See protein sequence)

Recommended Name: 5-aminolevulinate synthase, nonspecific, mitochondrial precursor

Size: 640 amino acids; 70581 Da

Cofactor: Pyridoxal phosphate

Subunit: Homodimer

Subcellular location: Mitochondrion matrix

Miscellaneous: There are two delta-ALA synthetase in vertebrates: an erythroid- specific form and

one (housekeeping) which is expressed in all tissues

Sequence caution: Sequence=CAA68506.1; Type=Frameshift; Positions=Several;

Alternative splicing: 2 isoforms: P13196-1 P13196-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000679.1 NP_954635.1

ENSEMBL proteins:

ENSP00000309259 ENSP00000378416

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Alas1)
	Human Recombinant Proteins from Abnova (ALAS1)

OriGene Purified Recombinant Human Protein: ALAS1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005759	mitochondrial matrix	IEA	--

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Antibodies for ALAS1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ALAS1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Alas1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ALAS1)
	Novus Biologicals Antibodies for ALAS1

Assays for ALAS1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P13196

ProtoNet protein and cluster: P13196

2 Blocks protein families:

IPB001917 Aminotransferase

IPB004839 Aminotransferase

UniProtKB/Swiss-Prot: HEM1_HUMAN, P13196

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALAS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALAS1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000688

Applied Biosystems Silencer® siRNAs for ALAS1

Sigma-Aldrich siRNA for ALAS1

Sigma-Aldrich shRNA for ALAS1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000688
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000688
untagged cDNA clones in CMV expression vector (see all 3): NM_000688

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000688

UniProtKB/Swiss-Prot: HEM1_HUMAN, P13196

Catalytic activity: Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2)

Enzyme Number (IUBMB): EC 2.3.1.37

Genatlas biochemistry entry for ALAS1:

aminolevulinate,delta-,synthase 1,housekeeping gene,liver,mitochondrial,pyridoxal

dependent,catalyzing the first step of porphyrin biosynthesis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003870	5-aminolevulinate synthase activity	IEA	--
GO:0008415	acyltransferase activity	IEA	--
GO:0016769	transferase activity, transferring nitrogenous groups	IEA	--
GO:0030170	pyridoxal phosphate binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for ALAS1 (Your Favorite Gene powered by Ingenuity) (see all 7 )

LPS/IL-1 Mediated Inhibition of RXR Function
PXR/RXR Activation
Aminophosphonate Metabolism
Methionine Metabolism
Lysine Biosynthesis

GeneDecks ALAS1 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: HEM1_HUMAN, P13196

Pathway: Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step

1/1

Gene Network Central^TM Interacting Genes and Proteins Network for ALAS1

5/33 Interacting proteins for ALAS1 (ENSP00000309259³) via UniProtKB, MINT, and/or STRING (see all 33 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALAD	ENSP00000363288³	STRING (score=.983)
GCAT	ENSP00000248924³	STRING (score=.914)
NF1	ENSP00000351015³	STRING (score=.909)
AGXT	ENSP00000302620³	STRING (score=.906)
ALAS2	ENSP00000332369³	STRING (score=.906)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006783	heme biosynthetic process	TAS	2347585
GO:0009058	biosynthetic process	IEA	--
GO:0033014	tetrapyrrole biosynthetic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ALAS1
10 Novoseek chemical compound relationships for ALAS1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
5-aminolevulinic acid	92.87	53	11343251 (3), 11267664 (2), 12191993 (2), 1859461 (1) (see all 38)
porphobilinogen	71.79	4	2032026 (1), 15144063 (1), 11343251 (1)
actb	70.88	2	16600798 (1), 16211407 (1)
haem	66.11	5	11202048 (1), 11267664 (1), 15134506 (1), 15269772 (1)
porphyrin	44.46	2	17975826 (1), 8171439 (1)
iron	40.42	8	9521555 (2), 8645006 (1), 1415186 (1), 2095458 (1) (see all 5)
histidine	6.11	2	17469798 (1), 9488633 (1)
leucine	4.23	1	16234850 (1)
phosphatidylinositol	4.05	1	11716532 (1)
oxygen	0.00	1	16234850 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALAS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALAS1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000688

Sigma-Aldrich siRNA for ALAS1

Sigma-Aldrich shRNA for ALAS1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000688 NM_199166

REFSEQ mRNAs for ALAS1 gene (2 alternative transcripts):

NM_000688.4 NM_199166.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000688 NM_199166

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000688
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000688
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000688

Additional cDNA sequence:

AB063322.1 AK293190.1 AK300993.1 AK312566.1 AY260745.1 BC011798.2 BC063005.1 CR590706.1

CR596499.1 CR606089.1 X56351.1 Y00451.1

18 DOTS entries:

DT.448881 DT.100825677 DT.100825666 DT.100825667 DT.100825673 DT.120879853 DT.91759072 DT.95217360

DT.100702945 DT.95246281 DT.100030041 DT.100650319 DT.100825670 DT.91759069 DT.95217385 DT.100825669

DT.91673142 DT.92028635

24/369 AceView cDNA sequences (see all 369 ):

AL531651 AV719828 BF309801 BG177527 AA434424 F02941 BQ641463 CA438637

CN479671 BI826786 BC011798 AL555603 BM993790 BG768228 AA431231 CF272420

NM_000688 CA392829 AA921941 AI092380 BI334617 AL553505 CR590706 BU623798

highest scoring ESTs for ALAS1:

Y00451 AA070207 AA099824 AA348927 AA431231 AA432252 AA434197 AA434424 AA447761 AA470668

Unigene Cluster for ALAS1:

Aminolevulinate, delta-, synthase 1

Hs.476308 [show with all ESTs]

Unigene Representative Sequence: NM_000688

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ALAS1 (see all 7 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b
SP1:											-
SP2:									-		-
SP3:									-		-		-
SP4:									-		-
SP5:											-		-

About this scheme

ECgene alternative splicing isoforms for ALAS1

2 Ensembl transcripts including schematic representations:

ENST00000310271 ENST00000394965

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ALAS1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALAS1

¹ / ² / ³

3 probe-sets matching ALAS1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37674_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	Y00451	1.00	1.00	1.00	1
205633_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000688	0.60	1.00	0.82	1
205633_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ALAS1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACCTCAATTA

SOURCE GeneReport for Unigene cluster: Hs.476308
Expression variation in blood from EXPOLDB for ALAS1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALAS1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALAS1¹	--	aminolevulinate, delta-, synthase 1	91.72(n) 95.31(a)	476600 XM_533804.2 XP_533804.2
chimpanzee (Pan troglodytes)	ALAS1¹	--	aminolevulinate, delta-, synthase 1	99.58(n) 100(a)	460416 XM_001171508.1 XP_001171508.1
cow (Bos taurus)	ALAS1¹	--	aminolevulinate, delta-, synthase 1	88.28(n) 90.78(a)	534286 XM_866156.2 XP_871249.2
mouse (Mus musculus)	Alas1^{1, 5}	9⁵	aminolevulinic acid synthase 1^{1, 5}	87.53(n)¹ 91.71(a)¹	11655¹ NM_020559.1¹ NP_065584.1¹ AF255616⁵ AK077152⁵ (see all 11)
chicken (Gallus gallus)	ALAS1¹	--	aminolevulinate, delta-, synthase 1	76.57(n) 84.04(a)	552895 NM_001018012.1 NP_001018012.1

About this table Species with no ortholog for ALAS1

ENSEMBL Gene Tree for ALAS1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALAS1 gene

GCAT² ALAS2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/62 NCBI SNPs in ALAS1 are shown (see all 62 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 42)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs709315^1,2	C,F,H	52207225(-)	`GTCCGG/AGAGCA`	2	--	ut5¹ ese³		8		EA NA EU WA	640
	rs17052020^1,2	F,H	52223615(+)	`CTGTAT/CTCTAG`	2	--	ng3¹		7		NA EU EA WA	560
--	rs104903^1,2	A	52205515(+)	`gctcaA/Tgccta`	2	--	ng5¹		0	--	--	--	--
--	rs17052017^1,2	H	52220375(+)	`CGCCAG/ACACGA`	2	N/S	mis¹ ese³		5		MN EU EA WA	588
--	rs104902^1,2	A	52205480(+)	`CCCCCA/CAAAAA`	2	--	ng5¹		0	--	--	--	--
	rs352168^1,2	A,C,F,H,O	52213010(-)	`TGCATG/AATGTC`	2	I/I	syn¹		9		MN EU EA WA NA	820
	rs352169^1,2	A,C,F,H,O	52211802(-)	`CACAAC/TTCATC`	2	--	int¹		26		EA NA MN EU WA	3462
	rs352166^1,2	A,C,F,H,O	52213717(-)	`GAATGG/ATGGTT`	2	--	int¹		14		EA NA EU WA	1036
	rs352165^1,2	A,C,F,H,O	52217942(-)	`AATGTT/CTATAA`	2	--	int¹		14		EA NA EU WA	738
	rs352167^1,2	A,C,F,H,O	52213696(-)	`GCTGCA/GTTTTG`	2	--	int¹		13		NA EU EA WA	1160

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HapMap Linkage Disequilibrium images for ALAS1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 125290

5 Novoseek disease relationships for ALAS1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
anemia sideroblastic	92.18	11	1415186 (4), 8089650 (1), 7592563 (1), 10496043 (1) (see all 6)
anemia congenital sideroblastic	83.09	1	15217771 (1)
porphyria hepatic	78.33	2	11343251 (2)
porphyria acute intermittent	73.40	1	2095458 (1)
porphyria	71.20	2	10692079 (1), 2095458 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/89 PubMed articles for ALAS1 gene (see all 89 ):

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Two different genes encode delta-aminolevulinate synthase in humans: nucleotide sequences of cDNAs for the housekeeping and erythroid genes. (PubMed id 2263504)^{3, 4} Bishop D.F. (1990)
Sequence of human 5-aminolevulinate synthase cDNA. (PubMed id 3671094)^{3, 4} Bawden M.J....Elliott W.H. (1987)
Human delta-aminolevulinate synthase: assignment of the housekeeping gene to 3p21 and the erythroid-specific gene to the X chromosome. (PubMed id 2347585)^{1, 3} Bishop D.F....Astrin K.H. (1990)
Peroxisome proliferator-activated receptor alpha controls hepatic heme biosynthesis through ALAS1. (PubMed id 19289130)^{1, 3} Degenhardt T....Carlberg C. (2009)
Hepatic nuclear factor 3 and nuclear factor 1 regulate 5-aminolevulinate synthase gene expression and are involved in insulin repression. (PubMed id 15123725)^{1, 3} Scassa M.E....Canepa E.T. (2004)
Molecular regulation of 5-aminolevulinate synthase. Diseases related to heme biosynthesis. (PubMed id 2095458)^{1, 3} May B.K....Cox T.C. (1990)
Inhibitory effect of AP-1 complex on 5-aminolevulinate synthase gene expression through sequestration of cAMP-response element protein (CRE)-binding protein (CBP) coactivator. (PubMed id 12433930)^{1, 3} Guberman A.S....Canepa E.T. (2003)
Alternative splicing and tissue-specific transcription of human and rodent ubiquitous 5-aminolevulinate synthase (ALAS1) genes. (PubMed id 11267664)^{1, 3} Roberts A.G. and Elder G.H. (2001)
Assignment of the human housekeeping delta-aminolevulinate synthase gene (ALAS1) to chromosome band 3p21.1 by PCR analysis of somatic cell hybrids. (PubMed id 7698013)^{1, 3} Cotter P.D....Bishop D.F. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 211	HGNC: 396	AceView: ALAS1	Ensembl:ENSG00000023330	euGenes: HUgn211
ECgene: ALAS1	H-InvDB: ALAS1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ALAS1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ALAS1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALAS1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALAS1		Antibodies for ALAS1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ALAS1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ALAS1

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Antibodies for ALAS1

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ALAS1 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for ALAS1

Summaries
for ALAS1

Genomic Location
for ALAS1

Proteins
for ALAS1

Protein Domains/
Families
for ALAS1

Gene Function
for ALAS1

Pathways & Interactions
for ALAS1

Drugs & Compounds
for ALAS1

Transcripts
for ALAS1

Expression
for ALAS1

Orthologs
for ALAS1

Paralogs
for ALAS1

SNPs/Variants
for ALAS1

Disorders & Mutations
for ALAS1

Medical News
for ALAS1

Publications
for ALAS1

Search for ALAS1

Genome Databases showing ALAS1

Other Databases showing ALAS1

Specialized Databases showing ALAS1

Licensable Technologies
for ALAS1

Services
for ALAS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALAS1 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor ALAS1

Summariesfor ALAS1

Genomic Locationfor ALAS1

Proteinsfor ALAS1

Protein Domains/Familiesfor ALAS1

Gene Functionfor ALAS1

Pathways & Interactionsfor ALAS1

Drugs & Compoundsfor ALAS1

Transcriptsfor ALAS1

Expression for ALAS1

Orthologsfor ALAS1

Paralogsfor ALAS1

SNPs/Variantsfor ALAS1

Disorders & Mutationsfor ALAS1

Medical Newsfor ALAS1

Publicationsfor ALAS1

Search for ALAS1

Genome Databases showing ALAS1

Other Databases showing ALAS1

Specialized Databases showing ALAS1

Licensable Technologiesfor ALAS1

Servicesfor ALAS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALAS1

Summaries
for ALAS1

Genomic Location
for ALAS1

Proteins
for ALAS1

Protein Domains/
Families
for ALAS1

Gene Function
for ALAS1

Pathways & Interactions
for ALAS1

Drugs & Compounds
for ALAS1

Transcripts
for ALAS1

Expression
for ALAS1

Orthologs
for ALAS1

Paralogs
for ALAS1

SNPs/Variants
for ALAS1

Disorders & Mutations
for ALAS1

Medical News
for ALAS1

Publications
for ALAS1

Licensable Technologies
for ALAS1

Services
for ALAS1