Aliases for ALAD Gene
External Ids for ALAD Gene
Previous GeneCards Identifiers for ALAD Gene
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
GeneCards Summary for ALAD Gene
ALAD (Aminolevulinate Dehydratase) is a Protein Coding gene. Diseases associated with ALAD include porphyria, acute hepatic and porphyria due to ala dehydratase deficiency. Among its related pathways are Metabolism and Porphyrin and chlorophyll metabolism. GO annotations related to this gene include identical protein binding and lead ion binding.
UniProtKB/Swiss-Prot for ALAD Gene
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.