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AKTIP Gene

protein-coding   GIFtS: 55
GCID: GC16M053524

AKT Interacting Protein

(Previous names: fused toes (mouse) homolog, fused toes homolog (mouse))
(Previous symbol: FTS)
  See AKTIP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
AKT Interacting Protein1 2     Fused Toes Homolog (Mouse)1
FTS1 2 3 5     AKT-Interacting Protein2
Fused Toes Protein Homolog2 3     Fused Toes Homolog2
FT12 5     Ft13
Fused Toes (Mouse) Homolog1     

External Ids:    HGNC: 167101   Entrez Gene: 644002   Ensembl: ENSG000001669717   OMIM: 6084835   UniProtKB: Q9H8T03   

Export aliases for AKTIP gene to outside databases

Previous GC identifers: GC16M052082 GC16M039412


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AKTIP Gene:
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while
homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological
abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is
similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine
residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly
with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the
phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the
same protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for AKTIP Gene:
AKTIP (AKT interacting protein) is a protein-coding gene. Diseases associated with AKTIP include balanitis, and balanitis xerotica obliterans. GO annotations related to this gene include small conjugating protein ligase activity.

UniProtKB/Swiss-Prot: AKTIP_HUMAN, Q9H8T0
Function: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle
trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates
apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the
AKT1/GSK3B/NFATC1 signaling cascade

Gene Wiki entry for AKTIP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AKTIP gene promoter:
         Oct-B1   LHX3b/Lhx3b   oct-B3   oct-B2   p53   ATF-2   MyoD   AP-4   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAKTIP promoter sequence
   Search Chromatin IP Primers for AKTIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKTIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.2   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q12.2

AKTIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKTIP gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M053524:  view genomic region     (about GC identifiers)

Start:
53,524,952 bp from pter      End:
53,538,323 bp from pter
Size:
13,372 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AKTIP_HUMAN, Q9H8T0 (See protein sequence)
Recommended Name: AKT-interacting protein  
Size: 292 amino acids; 33128 Da
Subunit: Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more
members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with HOOK1, HOOK2 and
HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Also interacts
with AKT1
Caution: Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity
Secondary accessions: Q503B1 Q53H38
Alternative splicing: 2 isoforms:  Q9H8T0-1   Q9H8T0-2   

Explore the universe of human proteins at neXtProt for AKTIP: NX_Q9H8T0

Explore proteomics data for AKTIP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AKTIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001012398.1  NP_071921.1  

    ENSEMBL proteins: 
     ENSP00000378152   ENSP00000300245   ENSP00000455874   ENSP00000454269   ENSP00000456418  
     ENSP00000458118   ENSP00000454771   ENSP00000456922   ENSP00000456398  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    2 InterPro protein domains:
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry Q9H8T0

    ProtoNet protein and cluster: Q9H8T0

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: AKTIP_HUMAN, Q9H8T0
    Similarity: Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily


    Find genes that share domains with AKTIP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKTIP_HUMAN, Q9H8T0
    Function: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle
    trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates
    apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the
    AKT1/GSK3B/NFATC1 signaling cascade

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18799622
    GO:0016881acid-amino acid ligase activity ----
    GO:0019787NOT small conjugating protein ligase activity NAS18799622
         
    Find genes that share ontologies with AKTIP           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for AKTIP:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         1 MGI phenotypic allele for Aktip (no phenotypes)

    Find genes that share phenotypes with AKTIP           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AKTIP
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AKTIP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AKTIP

    miRNA
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    miRTarBase miRNAs that target AKTIP:
    hsa-mir-615-3p (MIRT040167)

    Block miRNA regulation of human, mouse, rat AKTIP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AKTIP (see all 23):
    hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-302e hsa-miR-3162-5p hsa-miR-520a-3p hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidAKTIP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AKTIP

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    Sino Biological Human cDNA Clone for AKTIP
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    Addgene plasmids for AKTIP 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AKTIP_HUMAN, Q9H8T0: Cytoplasm. Cell membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus4
    nucleus4
    cytosol3
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus ----
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus ----
    GO:0005886plasma membrane IDA14749367
    GO:0030897colocalizes with HOPS complex IDA18799622

    Find genes that share ontologies with AKTIP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AKTIP
    Interactions:

        Search GeneGlobe Interaction Network for AKTIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AKTIP (Q9H8T02, 3 ENSP000003002454) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLA2Q141812, 3, ENSP000002654654MINT-64326 I2D: score=5 STRING: ENSP00000265465
    GTF3C1Q127892, 3MINT-64321 I2D: score=5 
    IMMTQ168912, 3MINT-64322 I2D: score=5 
    KIAA1377Q9P2H02, 3MINT-64328 I2D: score=5 
    RPA1P276942, 3MINT-64320 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation IDA14749367
    GO:0006915apoptotic process IEA--
    GO:0007032endosome organization IMP18799622
    GO:0007040lysosome organization IMP18799622
    GO:0008333endosome to lysosome transport IMP18799622

    Find genes that share ontologies with AKTIP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AKTIP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AKTIP gene (2 alternative transcripts): 
    NM_001012398.1  NM_022476.2  

    Unigene Cluster for AKTIP:

    AKT interacting protein
    Hs.380897  [show with all ESTs]
    Unigene Representative Sequence: AK098222
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394657(uc002ehk.3 uc002ehl.3 uc002ehm.3) ENST00000300245
    ENST00000571523 ENST00000565431 ENST00000570004 ENST00000568022 ENST00000563928
    ENST00000563108(uc010vgx.2) ENST00000565408 ENST00000568596 ENST00000566045
    ENST00000561799 ENST00000570041 ENST00000564497
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate AKTIP (see all 23):
    hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-302e hsa-miR-3162-5p hsa-miR-520a-3p hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidAKTIP 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): AKTIP (NM_022476)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKTIP
    Addgene plasmids for AKTIP 
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    OriGene qSTAR qPCR primer pairs in human, mouse for AKTIP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AKTIP
      QuantiTect SYBR Green Assays in human, mouse, rat AKTIP
      QuantiFast Probe-based Assays in human, mouse, rat AKTIP

    Additional mRNA sequence: 

    AK023320.1 AK098222.1 AK222743.1 AK303503.1 AL133106.1 BC001134.2 BC095401.1 CR457308.1 

    14 DOTS entries:

    DT.91760647  DT.448175  DT.100653052  DT.100653002  DT.95360281  DT.100653049  DT.100810221  DT.100686955 
    DT.91760640  DT.120660010  DT.95360300  DT.100876483  DT.99958778  DT.120848711 

    Selected AceView cDNA sequences (see all 216):

    F01365 CB164563 NM_022476 CK823054 AA677646 AA426333 CB993009 AI399852 
    AK023320 BE408328 BU507920 AI367047 AA731397 AA557333 CD721976 AW592536 
    CR457308 BQ100988 BE467093 CK429727 AI128672 BQ215485 AA417985 BF724708 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AKTIP (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ·
    SP1:              -     -     -     -     -                                   -                 -                 -                       -                     
    SP2:              -     -     -     -     -                                   -                 -                 -                       -                     
    SP3:                    -     -     -     -                                   -                 -                 -                       -                     
    SP4:                    -     -     -     -                                   -                 -                 -                                             
    SP5:                                -     -                                   -                 -                 -                                             

    ExUns: 15c · 15d
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for AKTIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AKTIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGCATAGG
    AKTIP Expression
    About this image


    AKTIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             T-Cytotoxic Cells Peripheral Blood
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
    AKTIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKTIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.380897
        Custom PCR Arrays for AKTIP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKTIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AKTIP gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aktip1 , 5 thymoma viral proto-oncogene 1 interacting protein1, 5 89.61(n)1
    96.23(a)1
      8 (44.25 cM)5
    143391  NM_010241.41  NP_034371.11 
     911120415 
    chicken
    (Gallus gallus)
    Aves AKTIP1 AKT interacting protein 80.71(n)
    87.67(a)
      415720  NM_001005838.1  NP_001005838.1 
    lizard
    (Anolis carolinensis)
    Reptilia AKTIP6
    AKT interacting protein
    87(a)
    1 ↔ 1
    LGc(454053-474162)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.339302 Xenopus laevis transcribed sequence with moderate similarity more 77.52(n)    BJ622387.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fts2 fused toes homolog 78.39(n)   378716  BC044455.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cbx1 crossbronx 50.08(n)
    39.34(a)
      47272  NM_080149.4  NP_524888.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-196
    Protein UBC-19 (ubc-19) mRNA, complete cds
    28(a)
    1 ↔ 1
    V(18686321-18689843) WBGene00006714


    ENSEMBL Gene Tree for AKTIP (if available)
    TreeFam Gene Tree for AKTIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AKTIP gene
    1 SIMAP similar gene for AKTIP using alignment to 7 protein entries:     AKTIP_HUMAN (see all proteins):
    DKFZp434G1122

    Find genes that share paralogs with AKTIP           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for AKTIP
    PGOHUM00000242433 PGOHUM00000247893 PGOHUM00000238041 PGOHUM00000235533


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AKTIP (see all 272)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1119048061,2
    C--53526062(+) AAAAATACT/-  
            
    TACTT
    2 -- ut311Minor allele frequency- -:0.50CSA 2
    rs3710043891,2
    C--53526064(+) ACTTA-/CTTA  
            
    CTTAA
    4 -- ut310--------
    rs38642461,2
    --53526093(+) AATAAC/TTTGGA 2 -- ut310--------
    rs40021621,2
    --53526136(-) ACTTCG/TGTCAG 2 -- ut31 ese30--------
    rs1501270201,2
    C--53526172(+) CAAACC/GCTGCT 2 -- ut310--------
    rs39562811,2
    --53526242(-) TGCCTG/TAAGAG 2 -- ut31 ese30--------
    rs28924381,2
    --53526302(-) TGCACC/TATGCA 2 -- ut31 ese30--------
    rs1458471181,2
    C,F--53526365(+) CTGTAC/TTGAGC 4 I V mis12Minor allele frequency- T:0.00NA EU 5873
    rs169522721,2
    C,F,H--53526366(+) TGTACT/CGAGCC 4 /S syn1 ese310Minor allele frequency- C:0.01NA NS EA WA 5230
    rs2019815791,2
    C--53526377(+) AGGCTT/CTACCC 4 /K /E mis11Minor allele frequency- C:0.00EU 1323

    HapMap Linkage Disequilibrium report for AKTIP (53524952 - 53538323 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AKTIP: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AKTIP
    DNA2.0 Custom Variant and Variant Library Synthesis for AKTIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608483    OMIM disorders: --

    3 diseases for AKTIP:    
    About MalaCards
    balanitis    balanitis xerotica obliterans    thymic hyperplasia

    1 disease from the University of Copenhagen DISEASES database for AKTIP:
    Balanitis xerotica obliterans

    Find genes that share disorders with AKTIP           About GenesLikeMe

    Genetic Association Database (GAD): AKTIP
    Human Genome Epidemiology (HuGE) Navigator: AKTIP (3 documents)

    Export disorders for AKTIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AKTIP gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with AKTIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients. (PubMed id 20132317)1, 4 Magno L.A....Romano-Silva M.A. (Genes Brain Behav. 2010)
    2. Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. (PubMed id 19270026)1, 4 Quaye L.... Gayther S.A. (Hum. Mol. Genet. 2009)
    3. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. (PubMed id 18799622)1, 2 Xu L.... Harper J.W. (Mol. Biol. Cell 2008)
    4. Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. (PubMed id 14749367)1, 2 Remy I. and Michnick S.W. (Mol. Cell. Biol. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. A cDNA encoding the calcitonin gene-related peptide type 1 receptor. (PubMed id 8626685)1, 3 Aiyar N.... Li Y. (J. Biol. Chem. 1996)
    8. Ft1, a novel gene related to ubiquitin-conjugating enzymes, is deleted in the Fused toes mouse mutation. (PubMed id 9383278)1, 9 Lesche R....RA1ther U. (Mamm. Genome 1997)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Fused Toes Homolog modulates radiation cytotoxicity in uterine cervical cancer cells. (PubMed id 21424602)1 Anandharaj A....Park W.Y. (Mol. Biol. Rep. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64400 HGNC: 16710 AceView: FTS Ensembl:ENSG00000166971 euGenes: HUgn64400
    ECgene: AKTIP H-InvDB: AKTIP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AKTIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AKTIP gene:
    Search GeneIP for patents involving AKTIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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