Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AKT3 Gene

protein-coding   GIFtS: 71
GCID: GC01M243653

v-akt murine thymoma viral oncogene homolog 3 (protein kinase...
 Explore 60 diseases affiliated with
AKT3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AKT3    

Aliases
for AKT3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma)1 2     MPPH2
PKBG1 2 3 5     PKB-GAMMA2
PRKBG1 2     RAC-Gamma Serine/Threonine Protein Kinase2
RAC-Gamma1     RAC-Gamma Serine/Threonine-Protein Kinase2
RAC-PK-Gamma1     Protein Kinase Akt-33
STK-22 3     Protein Kinase B Gamma3
PKB Gamma2 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    HGNC: 3931   Entrez Gene: 100002   Ensembl: ENSG000001170207   OMIM: 6112235   UniProtKB: Q9Y2433   

Export aliases for AKT3 gene to outside databases

Previous GC identifers: GC01M241568 GC01M238913 GC01M239853 GC01M240598 GC01M239977 GC01M241718 GC01M214031


Summaries
for AKT3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AKT3:
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT
kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a
wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well
as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth
factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding
distinct isoforms have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AKT3_HUMAN, Q9Y243
Function: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT
kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis.
This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100
substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3
is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of
malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via
IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular
energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD,
resulting in the induction of caspase-dependent apoptosis

summary for AKT3:
Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival,
insulin signaling, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway,
resulting in the recruitment of Akt to the plasma membrane via the PH (plexstrin homology domain) of Akt.
Akt is fully activated by phosphorylation at two key sites: Ser308 (phosphorylated by PDK1) and Thr478
(phosphorylated by mTOR and DNA-PK). Akt can then phosphorylated a wide range of substrates including
transcription factors (e.g. FOXO1), kinases (GSK-3, Raf-1, ASK, Chk1) and other proteins with important
signaling roles (e.g. Bad, MDM2). There are three isoforms of Akt; Akt 1, 2 and 3 (also known as PKBalpha,
beta and gamma).

Gene Wiki entry for AKT3


Genomic Views
for AKT3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AKT3 gene promoter:
         MEF-2A   FAC1   Sp1   POU3F2   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): AKT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for AKT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

AKT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKT3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M243653:  view genomic region     (about GC identifiers)

Start:
 243,651,535 bp from pter      End:
 244,014,381 bp from pter
Size:
 362,847 bases      Orientation:
 minus strand

Proteins
for AKT3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AKT3_HUMAN, Q9Y243 (See protein sequence)
Recommended Name: RAC-gamma serine/threonine-protein kinase  
Size: 479 amino acids; 55775 Da
Subunit: Interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation. Interacts with TRAF6
Subcellular location: Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell
stimulation leading to its translocation
Caution: In light of strong homologies in the primary amino acid sequence, the 3 AKT kinases were long surmised to play
redundant and overlapping roles. More recent studies has brought into question the redundancy within AKT kinase
isoforms and instead pointed to isoform specific functions in different cellular events and diseases. AKT1 is more
specifically involved in cellular survival pathways, by inhibiting apoptotic processes; whereas AKT2 is more specific
for the insulin receptor signaling pathway. Moreover, while AKT1 and AKT2 are often implicated in many aspects of
cellular transformation, the 2 isoforms act in a complementary opposing manner. The role of AKT3 is less clear, though
it appears to be predominantly expressed in brain
1 PDB 3D structure from and Proteopedia for AKT3:
2X18 (3D)    
Secondary accessions: Q0VAA6 Q5VTI1 Q5VTI2 Q96QV3 Q9UFP5
Alternative splicing: 2 isoforms:  Q9Y243-1   Q9Y243-2   

Explore the universe of human proteins at neXtProt for AKT3: NX_Q9Y243

Post-translational modifications:

  • Phosphorylation on Thr-305 and Ser-472 is required for full activity (By similarity)1
  • Ubiquitinated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination
    • catalyzed by TTC3, leading to its degradation by the proteasome1
  • O-GlcNAcylation at Thr-302 and Thr-309 inhibits activating phosphorylation at Thr-305 via disrupting the interaction
    • between AKT and PDK1 (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y243

    • 4/33 DME Specific Peptides for AKT3 (Q9Y243) (see all 33)
     YYAMKIL  GVVMYEM  AEIVSAL  IKITDFG 

    AKT3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001193658.1  NP_005456.1  NP_859029.1  

    ENSEMBL proteins: 
     ENSP00000336943   ENSP00000355498   ENSP00000355497   ENSP00000447820   ENSP00000263826  
    Reactome Protein details: Q9Y243
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant AKT3 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for AKT3
    OriGene Purified Proteins (see all 2): AKT3
    OriGene Protein Over-expression Lysate (see all 2): AKT3
    OriGene Custom Protein Services for AKT3 
    GenScript Custom Purified and Recombinant Proteins Services for AKT3
    Novus Biologicals AKT3 Proteins
    Novus Biologicals AKT3 Lysates
    Sino Biological Recombinant Protein for AKT3
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane IDA--


    AKT3 for ontologies           About GeneDecksing



    AKT3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of AKT3
    R&D Systems Antibodies for AKT3
    Cell Signaling Technology (CST) Antibodies for AKT3 
    OriGene Antibodies (see all 6): AKT3
    OriGene Custom Antibody Services for AKT3 
    GenScript Superior Antibodies for AKT3
    Novus Biologicals AKT3 Antibodies
    Search for Antibodies for AKT3 at Abcam  
    Browse Antibodies at Uscn
    ThermoFisher Antibody for AKT3

    Assay Products for AKT3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for AKT3         (see all)
    GenScript AKT3-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for AKT3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for AKT3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AKT3 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry Q9Y243

    ProtoNet protein and cluster: Q9Y243

    2 Blocks protein families:
    IPB000961 Protein kinase C-terminal domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: AKT3_HUMAN, Q9Y243
    Domain: Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the
    plasma membrane
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 protein kinase domain


    Function
    for AKT3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AKT3_HUMAN, Q9Y243
    Function: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT
    kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis.
    This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100
    substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3
    is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of
    malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via
    IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular
    energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD,
    resulting in the induction of caspase-dependent apoptosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Two specific sites, one in the kinase domain (Thr-305) and the other in the C-terminal regulatory
    region (Ser-472), need to be phosphorylated for its full activation (By similarity). IGF-1 leads to the activation of
    AKT3, which may play a role in regulating cell survival
    Biophysicochemical properties: Kinetic parameters: KM=87.9 uM for ATP (for purified and in vitro activated AKT3);
    KM=12.4 uM for peptide substrate (for purified and in vitro activated AKT3); KM=118.7 uM for ATP (for recombinant
    myristoylated AKT3 expressed and immunoprecipitated from Rat-1 cells); KM=2.3 uM for peptide substrate (for
    recombinant myristoylated AKT3 expressed and immunoprecipitated from Rat-1 cells);

         Genatlas biochemistry entry for AKT3:
    V-akt murine thymoma viral oncogen homolog 3,general mediator of cell survival,induced by insulin growth factor 1,AKT3
    and others,widely expressed but not in liver and skeletal muscle

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
    Products:            		miRTarBase miRNAs that target AKT3:
    hsa-mir-122 (MIRT003099)

    OriGene 3'-UTR Clone (see all 2): AKT3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKT3
    8/89 QIAGEN miScript miRNA Assays for microRNAs that regulate AKT3 (see all 89):
    hsa-miR-124* hsa-miR-520f hsa-miR-1321 hsa-miR-106a hsa-miR-15a hsa-miR-3653 hsa-miR-519a hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmid: AKT3 3' UTR sequence
    Inhib. RNA
    Products:            		EMD Millipore RNAi Products for the Analysis of AKT3 Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKT3 (see all 7)
    OriGene shRNA RFP: AKT3
    OriGene siRNA: AKT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKT3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for AKT3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKT3 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKT3 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): AKT3 (NM_005465)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKT3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for AKT3
    Search LifeMap BioReagents cell lines for AKT3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKT3

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10092583
    GO:0004674protein serine/threonine kinase activity IDA16540465
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IDA16540465
    GO:0005543phospholipid binding IEA--


    AKT3 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for AKT3:
     Cell cycle / mitosis defect  Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased mitotic index 

    Animal Models:
         Mouse knock-outs for AKT3: Akt3tm1Mbb Akt3tm1Hem
         12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Akt3):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system  normal 
     reproductive system  tumorigenesis 

    AKT3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for AKT3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/118 super-pathways (see all 118) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_CNTF receptor signaling
    8/18 pathways (see all 18)
    		Development_CNTF receptor signaling1.00
    		Translation Insulin regulation of translation0.35
    		Development CNTF receptor signaling1.00
    		Development_Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Transcription Receptor-mediated HIF regulation0.43
    		Development Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Transcription_Receptor-mediated HIF regulation0.43
    		Translation _Regulation of EIF4F activity0.32
    2Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    3IL-9 Signaling Pathways
    8/12 pathways (see all 12)
    		IL-9 Signaling Pathways1.00
    		IL-4 Signaling Pathways0.80
    		IL-21 Signaling Pathways0.90
    		Development_Thrombopoietin-regulated cell processes0.36
    		IL-7 Signaling Pathways0.90
    		Development Thrombopoietin-regulated cell processes0.36
    		Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    		Adipocytokines & Insulin Signaling0.33
    4Development HGF signaling pathway
    8/12 pathways (see all 12)
    		Development_HGF signaling pathway0.78
    		Apoptosis and survival NGF signaling pathway0.25
    		Development_Neurotrophin family signaling0.45
    		Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR10.24
    		Development Neurotrophin family signaling0.45
    		Apoptosis and survival Anti-apoptotic action of membrane-bound ESR10.24
    		Development EGFR signaling via PIP30.26
    		Apoptosis and survival_Role of CDK5 in neuronal death and survival0.24
    5PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/66 EMD Millipore Pathways for AKT3 (see all 66)
        Cytoskeleton remodeling FAK signaling
    G-protein signaling G-Protein beta/gamma signaling cascades
    Transcription NF-kB signaling pathway
    Development A2A receptor signaling
    Immune response IL-4 signaling pathway

    5/9 R&D Systems Pathways for AKT3 (see all 9)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    IL-7 Signaling Pathways

    5/35 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AKT3 (see all 35)
        LT-BetaR Pathway
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    TRKA Signaling
    PI3K Signaling in B-Lymphocyte

    1 Cell Signaling Technology (CST) Pathway for AKT3
        PI3K / Akt Signaling

    5/8 Tocris Bioscience Pathways for AKT3 (see all 8)
        Akt Pathway
    Insulin Pathway
    Toll-like Receptor Pathway
    Apoptosis Pathway
    TGF-beta Pathway

    5/69 GeneGo (Thomson Reuters) Pathways for AKT3 (see all 69)
        Development A2A receptor signaling
    Development CNTF receptor signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Signal transduction AKT signaling

    5/9 BioSystems Pathways for AKT3 (see all 9) 
        MAPK signaling pathway
    Integrin-mediated cell adhesion
    Focal Adhesion
    Signal Transduction of S1P Receptor
    ErbB signaling pathway

    5/52        Reactome Pathways for AKT3 (see all 52)
        Costimulation by the CD28 family
    Signaling by EGFR in Cancer
    Downregulation of ERBB2:ERBB3 signaling
    Negative regulation of the PI3K/AKT network
    Downstream signal transduction

    3 PharmGKB Pathways for AKT3
        EGFR Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    5/39         Kegg Pathways  (Kegg details for AKT3) (see all 39):
        MAPK signaling pathway
    ErbB signaling pathway
    Chemokine signaling pathway
    mTOR signaling pathway
    Apoptosis


    AKT3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AKT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/83 Interacting proteins for AKT3 (Q9Y2432, 3 ENSP000002638264) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP3P425742, 3, ENSP000003110324MINT-4820732 I2D: score=2 STRING: ENSP00000311032
    PRKCZQ055133, ENSP000003678304I2D: score=4 STRING: ENSP00000367830
    PDPK1O155303, ENSP000003442204I2D: score=2 STRING: ENSP00000344220
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    TSC2P498153, ENSP000002194764I2D: score=2 STRING: ENSP00000219476
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000002mitochondrial genome maintenance IMP18524868
    GO:0006468protein phosphorylation TAS10092583
    GO:0007165signal transduction IMP18524868


    AKT3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AKT3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AKT3 for compounds           About GeneDecksing

    EMD Millipore small molecules for AKT3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for AKT3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    10-DEBC hydrochlorideSelective Akt/PKB inhibitor[201788-90-1]
    API-2Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral[35943-35-2]
    GSK 690693Akt kinase inhibitor. Antitumor[937174-76-0]
    FPA 124Akt/PKB inhibitor[902779-59-3]

    2 HMDB Compounds for AKT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    5 Novoseek chemical compound relationships for AKT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ly294002 68 1 11322783 (1)
    phosphatidylinositol 57.5 2 10187787 (1)
    threonine 51.9 1 11387345 (1)
    serine 44.6 6 10208883 (3), 19401561 (1), 11387345 (1)
    lipid 0 1 10419456 (1)

    Search CenterWatch for drugs/clinical trials and news about AKT3 

    Transcripts
    for AKT3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AKT3 gene (3 alternative transcripts): 
    NM_001206729.1  NM_005465.4  NM_181690.2  

    Unigene Cluster for AKT3:

    V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
    Hs.498292  [show with all ESTs]
    Unigene Representative Sequence: NM_005465
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336199(uc001hzz.1) ENST00000366540(uc021plu.1) ENST00000366539(uc001iab.2)
    ENST00000492957 ENST00000552631 ENST00000463991 ENST00000491219 ENST00000490018
    ENST00000550388 ENST00000263826

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): AKT3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKT3
    8/89 QIAGEN miScript miRNA Assays for microRNAs that regulate AKT3 (see all 89):
    hsa-miR-124* hsa-miR-520f hsa-miR-1321 hsa-miR-106a hsa-miR-15a hsa-miR-3653 hsa-miR-519a hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmid: AKT3 3' UTR sequence
    Inhib. RNA
    Products:             		EMD Millipore RNAi Products for the Analysis of AKT3 Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKT3 (see all 7)
    OriGene shRNA RFP: AKT3
    OriGene siRNA: AKT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKT3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKT3 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKT3 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): AKT3 (NM_005465)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKT3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKT3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AKT3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKT3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKT3

    Additional cDNA sequence: 

    AF085234.1 AF124141.1 AF135794.1 AJ245709.1 AK055109.1 AK308052.1 AL080074.1 AL117525.1 
    AY005799.1 BC019085.2 BC020479.1 BC121154.2 U79271.1 

    15 DOTS entries:

    DT.456229  DT.100779293  DT.444498  DT.95169925  DT.95169929  DT.408249  DT.427466  DT.70103881 
    DT.92438232  DT.86856078  DT.207558  DT.91966549  DT.92062989  DT.95169930  DT.97859779 

    24/301 AceView cDNA sequences (see all 301):

    AW262782 CA943693 BX281089 CK431145 BF476021 AA479072 AW873705 BI917703 
    CA443079 R69631 T96180 BM724435 CA943632 AF135794 BM722084 AA398371 
    BQ100707 W72147 CA943661 D44972 CB129928 AA249299 BQ084082 BQ100985 

    GeneLoc Exon Structure


    Expression
    for AKT3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AKT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGGGTAACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AKT3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver BudLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See AKT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AKT3

    SOURCE GeneReport for Unigene cluster: Hs.498292

    UniProtKB/Swiss-Prot: AKT3_HUMAN, Q9Y243
    Tissue specificity: In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and
    liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including AKT3 (see all 7): 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Insulin Resistance in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKT3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AKT3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKT3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKT3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKT3

    Orthologs
    for AKT3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for AKT3 gene from 5/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves AKT31 v-akt murine thymoma viral oncogene homolog 3 (protein more 90.05(n)
    99.58(a)    		   421497  XM_419544.3  XP_419544.1 
    lizard
    (Anolis carolinensis)    		 Reptilia AKT36
    		 --
    		 98(a)
    		 1 ↔ 1
    		 GL343285.1(492046-548701)
    zebrafish
    (Danio rerio)    		 Actinopterygii akt3a1 v-akt murine thymoma viral oncogene homolog 3a 80.17(n)
    95.82(a)    		   560549  NM_001197201.1  NP_001184130.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Akt11 , 3 anti-apoptosis protein serine/threonine
    kinase3
    Akt11    		 63(a)3
    62.34(n)1
    67.32(a)1    		   89B63
    419571  NM_169705.11  NP_732113.31 
    worm
    (Caenorhabditis elegans)    		 Secernentea akt-13 PH (pleckstrin homology) domain, Protein
    kinase more    		 53(a)
    (best of 2)    		   V(10251544-10255039)   --


    ENSEMBL Gene Tree for AKT3 (if available)
    TreeFam Gene Tree for AKT3 (if available) 

    Paralogs
    for AKT3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AKT3 gene
    AKT12  RPS6KA62  RPS6KB12  SGK32  SGK22  RPS6KA12  RPS6KA52  RPS6KA42  
    SGK12  RPS6KB22  RPS6KA22  AKT22  RPS6KA32  
    18/72 SIMAP similar genes for AKT3 using alignment to 3 protein entries:     AKT3_HUMAN (see all proteins) (see all similar genes):
    AKT1    AKT2    SGK2    PRKCH    PKN1    PRKCZ
    KIN27    RPS6KB1    MARK4    PRKACB    PRKCE    PRKACA
    PRKCB    PRKCI    RPS6KA5    RPS6KA2    RPS6KA1    PRKCA

    AKT3 for paralogs           About GeneDecksing



    Genomic Variants
    for AKT3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5080 NCBI SNPs in AKT3 are shown (see all 5080)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs413158681,2
    		--214031163(+) CCCGGC/GACAGG 1 -- ds50010--------
    rs799497591,2
    		--214031364(+) AGCAGC/TGCCGG 1 -- ds50012Minor allele frequency- T:0.05CSA WA 119
    rs1138730481,2
    		--214033675(+) GGAGCG/AGGCCG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs783193611,2
    		--214033694(+) CCGAGC/TCACAG 1 -- int12Minor allele frequency- T:0.10CSA WA 119
    rs779089951,2
    		F,--214033796(+) ATGATT/GCTGGA 1 -- int11Minor allele frequency- G:0.02WA 118
    rs66952291,2
    		C,--214035582(+) CCCGGC/TGCTGT 1 -- int14Minor allele frequency- T:0.09NA WA 124
    rs66593421,2
    		C,A,--214035807(+) accacA/Gcctag 1 -- int13Minor allele frequency- G:0.17NA WA 6
    rs769138431,2
    		C--214036172(+) GGTCTT/CGAACT 1 -- int11Minor allele frequency- C:0.00NA 2
    rs593265411,2
    		--214036185(+) TGACCC/TCAGGT 1 -- int10--------
    rs752428921,2
    		C,F,--214037159(+) AGAGCC/TGAAAA 1 -- int11Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for AKT3 (243651535 - 243901535 bp, first 250kb of AKT3)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 19 variations for AKT3
         15/17 CNVs (see all 17): 71578 84947 84950 74964 34790 43767 84945 43289 60966 84946 84949 84951 97697 34791 74963
         2 Indels: 97695 84948
    Human Gene Mutation Database (HGMD): AKT3

    2 SABiosciences Cancer Mutation PCR Assays for AKT3:
    Cosmic IdAA Change
    48227p.Q124L
    13303p.G171R
    2 SABiosciences Cancer Mutation PCR Arrays containing AKT3:
    PI3K-PTEN Pathway
    Cancer Comprehensive Panel 384HT
    1 SABiosciences qBiomarker Copy Number PCR Array containing AKT3:
    Kinases & Phosphatases
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKT3
    DNA2.0 Custom Variant and Variant Library Synthesis for AKT3

    Disorders / Diseases
    for AKT3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AKT3 for disorders           About GeneDecksing

    OMIM gene information: 611223    OMIM disorders: --

    UniProtKB/Swiss-Prot: AKT3_HUMAN, Q9Y243
  • Note=AKT3 is a key modulator of several tumors like melanoma, glioma and ovarian cancer. Active AKT3 increases
    • progressively during melanoma tumor progression with highest levels present in advanced-stage metastatic melanomas.
    Promotes melanoma tumorigenesis by decreasing apoptosis. Plays a key role in the genesis of ovarian cancers through
    modulation of G2/M phase transition. With AKT2, plays a pivotal role in the biology of glioblastoma

    20/60 diseases for AKT3 (see all 60):    About MalaCards
    thymoma    corpus callosum agenesis    corpus callosum    salivary gland cancer
    primitive neuroectodermal tumor    neuroectodermal tumors    oral squamous cell carcinoma    squamous cell carcinoma
    myeloid leukemia    pancreatic ductal adenocarcinoma    anaplastic meningioma    papillary thyroid carcinoma
    tuberous sclerosis    chronic lymphocytic leukemia    chronic myeloid leukemia    acute myeloid leukemia
    lymphocytic leukemia    insulin resistance    kaposi's sarcoma    carcinoid tumors

    8 Novoseek disease relationships for AKT3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    skin cancer 33.2 1 18813315 (1)
    ovarian cancer 32.7 4 17178867 (3)
    melanoma 32.2 29 18451171 (7), 15466193 (6), 17440074 (5), 18813315 (3) (see all 6)
    tumors 31.5 20 15466193 (3), 18451171 (2), 10419456 (2), 17440074 (2) (see all 9)
    metastatic melanoma 29.1 1 15466193 (1)
    cancer 27.6 6 18813315 (2), 17047397 (1), 16552185 (1), 18392055 (1) (see all 5)
    breast cancer 12.3 5 10419456 (4), 20102399 (1)
    prostate cancer 2.37 7 10419456 (3), 20102399 (2), 16721361 (2)

    Human Genome Epidemiology (HuGE) Navigator: AKT3 (9 documents)

    Export disorders for AKT3 gene to outside databases

    Publications
    for AKT3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AKT3 gene, integrated from 9 sources (see all 142):
    (articles sorted by number of sources associating them with AKT3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site. (PubMed id 10208883)1, 2, 3, 9 Nakatani K....Roth R.A. (1999)
    2. A human protein kinase B gamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. (PubMed id 10092583)1, 2, 3 Brodbeck D.... Hemmings B.A. (1999)
    3. A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition. (PubMed id 17178867)1, 2, 9 Cristiano B.E....Pearson R.B. (2006)
    4. Deregulated Akt3 activity promotes development of malignant melanoma. (PubMed id 15466193)1, 2, 9 Stahl J.M....Robertson G.P. (2004)
    5. Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3. (PubMed id 10491192)1, 2, 9 Masure S.... Richardson A. (1999)
    6. Akt2 and Akt3 play a pivotal role in malignant glioma s. (PubMed id 20167810)1, 2, 9 Mure H....Nagahiro S. (2010)
    7. A novel AKT3 mutation in melanoma tumours and cell lines. (PubMed id 18813315)1, 2, 9 Davies M.A....Mills G.B. (2008)
    8. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PubMed id 11707444)1, 2, 9 Laine J.... Noguchi M. (2002)
    9. Two splice variants of PKB gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site Ser-472 in the C-terminal hydrophobic domain. (PubMed id 11387345)1, 2, 9 Brodbeck D.... Hemmings B.A. (2001)
    10. Kinetic mechanism of AKT/PKB enzyme family. (PubMed id 16540465)1, 2, 9 Zhang X....Kendall R.L. (2006)

    External Searches for AKT3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing AKT3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10000 HGNC: 393 AceView: AKT3 Ensembl:ENSG00000117020 euGenes: HUgn10000
    ECgene: AKT3 Kegg: 10000 H-InvDB: AKT3

    Other Databases showing AKT3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AKT3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AKT3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AKT3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for AKT3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AKT3 gene:
    Search GeneIP for patents involving AKT3

    Licensable Technologies for AKT3 gene:
     Salk Institute: Protein Kinase B/AKT Modulators and Methods of Use Thereof
     Tufts University:  Regulation of Oncogenesis by Akt-Specific Isoforms
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for AKT3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant AKT3 Protein
     EMD Millipore small molecules (inhibitor) for AKT3
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore RNAi Products for the Analysis of AKT3 Gene knock-down
     EMD Millipore Mono- and Polyclonal Antibodies for the study of AKT3
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for AKT3 (Akt3)   Browse Cell Culture Products  
     ELISAs for AKT3 (Akt3)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for AKT3 (Akt3)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for AKT3   OriGene shRNA RFP for AKT3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKT3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKT3  
     OriGene Protein Over-expression Lysate for AKT3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for AKT3   OriGene 3'-UTR Clone for AKT3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKT3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKT3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for AKT3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AKT3   OriGene Custom Protein Services for AKT3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AKT3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKT3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKT3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKT3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKT3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKT3
     GenScript Custom Purified and Recombinant Proteins Services for AKT3 GenScript cDNA clones with any tag delivered in your preferred vector for AKT3
     GenScript AKT3-Activity-based Kinase Assay for Compound Screening GenScript Superior Antibodies for AKT3
     GenScript Custom overexpressing Cell Line Services for AKT3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for AKT3 

     Regulatory tfbs in AKT3 promoter
     Search Chromatin IP Primers for AKT3
     RT2 qPCR Primer Assay in human, mouse, rat AKT3
     GNC Network for AKT3
     SABiosciences PCR Arrays including human, mouse, rat AKT3
     Tocris compounds for AKT3
     Proteins and Antibodies for AKT3
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Proteins for AKT3
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AKT3 antibodies
     AKT3 proteins
     AKT3 lysates
     Search for Antibodies for AKT3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for AKT3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for AKT3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKT3
     SwitchGear 3'UTR luciferase reporter plasmids for AKT3
     SwitchGear Promoter luciferase reporter plasmids for AKT3
     ThermoFisher Antibody for AKT3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKT3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      AKT3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4