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AKT3 Gene

protein-coding GIFtS: 69

GC01M241718

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp434N0250 ^²
EC 2.7.11.1 ^³
OTTHUMP00000037911 ^²
OTTHUMP00000037912 ^²
PKB-GAMMA ^²
PKBG ^¹, ², ³, ⁵
PRKBG ^¹, ²
RAC-PK-gamma ^², ³
RAC-gamma ^¹, ²
STK-2 ^², ³

Descriptions
AKT3 kinase ^²
PKB gamma ^³
Protein kinase Akt-3 ^³
Protein kinase B, gamma ^³
RAC-gamma serine/threonine protein kinase ^²
protein kinase B gamma ^²
serine threonine protein kinase, Akt-3 ^²
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) ^²

External Ids
HGNC: 393¹
Entrez Gene: 10000²
UniProtKB: Q9Y243³
Ensembl: ENSG00000117020⁷

Search outside databases for aliases for AKT3 gene

Previous GC identifers: GC01M241568 GC01M238913 GC01M239853 GC01M240598 GC01M239977

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AKT3:

The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein

kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and

growth factors. They are involved in a wide variety of biological processes including cell

proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and

glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor

(PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants

encoding distinct isoforms have been described. [provided by RefSeq]

UniProtKB/Swiss-Prot: AKT3_HUMAN, Q9Y243

Function: IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival.

Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the

second serine phosphorylation site could still be stimulated but to a lesser extent

Gene Wiki entry for AKT3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AKT3 gene

Entrez Gene cytogenetic band: 1q43-q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44

AKT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M241718: (about GC identifiers)

Start:	241,718,158 bp from pter
End:	242,080,053 bp from pter
Size:	361,896 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004836.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AKT3_HUMAN, Q9Y243 (See protein sequence)

Recommended Name: RAC-gamma serine/threonine-protein kinase

Size: 479 amino acids; 55775 Da

Subunit: Interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation

Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated

after cell stimulation leading to its translocation

Secondary accessions: Q0VAA6 Q5VTI1 Q5VTI2 Q96QV3 Q9UFP5

Alternative splicing: 2 isoforms: Q9Y243-1 Q9Y243-2

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_005456.1 NP_859029.1

ENSEMBL proteins:

ENSP00000375720 ENSP00000336943 ENSP00000355498 ENSP00000263826 ENSP00000375719 ENSP00000355497

Human Recombinant Proteins

	Invitrogen human recombinant proteins for AKT3
	Millipore Purified and/or Recombinant AKT3 Protein
	Sigma-Aldrich Proteins for AKT3
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for AKT3
	Recombinant Proteins from Abcam (AKT3, AKT1/2/3, AKT1/3)
	Human Recombinant Proteins from Abnova (AKT3)

OriGene Purified Recombinant Human Proteins (see all 2): AKT3

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0016020	membrane	IEA	--

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Antibodies for AKT3:

	Invitrogen Antibodies for AKT3
	Millipore Mono- and Polyclonal Antibodies for the study of AKT3
	Sigma-Aldrich Antibodies for AKT3
	R&D Systems Antibodies for AKT3
	Cell Signaling Technology (CST) Antibodies for AKT3
	Antibodies from Abcam (AKT3, AKT1/2/3, AKT1/3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AKT3)
	Novus Biologicals Antibodies for AKT3

Assays for AKT3:

	Invitrogen Assays for AKT3
	Millipore Kits and Assays for the Analysis of AKT3
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9Y243

ProtoNet protein and cluster: Q9Y243

2 Blocks protein families:

IPB000961 Protein kinase C-terminal domain

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: AKT3_HUMAN, Q9Y243

Domain: Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its

targeting to the plasma membrane

Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC

subfamily

Similarity: Contains 1 AGC-kinase C-terminal domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AKT3)
		Millipore RNAi Products for the Analysis of AKT3 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (AKT3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005465

Applied Biosystems Silencer® siRNAs for AKT3

Sigma-Aldrich siRNA and siRNA Panels for AKT3

Sigma-Aldrich shRNA Panels and shRNA for AKT3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005465
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005465
untagged cDNA clones in CMV expression vector (see all 4): NM_005465

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005465

UniProtKB/Swiss-Prot: AKT3_HUMAN, Q9Y243

Function: IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival.

Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the

second serine phosphorylation site could still be stimulated but to a lesser extent

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Two specific sites, one in the kinase domain (Thr-305) and the other in the

C-terminal regulatory region (Ser-472), need to be phosphorylated for its full activation (By

similarity)

Enzyme Number (IUBMB): EC 2.7.11.1

Genatlas biochemistry entry for AKT3:

V-akt murine thymoma viral oncogen homolog 3,general mediator of cell survival,induced by insulin

growth factor 1,AKT3 and others,widely expressed but not in liver and skeletal muscle

10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Akt3):

endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism	immune system
lethality-prenatal/perinatal	nervous system	normal	reproductive system	tumorigenesis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0005515	protein binding	IPI	12176997
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/73 Sigma-Aldrich "Your Favorite Gene" Pathways for AKT3 (Your Favorite Gene powered by Ingenuity) (see all 73 )

Amyloid Processing
PTEN Signaling
Neuregulin Signaling
IL-15 Signaling
Natural Killer Cell Signaling

GeneDecks AKT3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for AKT3

5/63 Interacting proteins for AKT3 (Q9Y243^{1, 2} ENSP00000263826³) via UniProtKB, MINT, and/or STRING (see all 63 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDC37	Q16543¹	EBI-296115, EBI-295634
CASP3	P42574²	MINT-4820732
PDPK1	ENSP00000344220³	STRING (score=.963)
TCL1A	ENSP00000216612³	STRING (score=.955)
PTEN	ENSP00000361021³	STRING (score=.945)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	TAS	10092583
GO:0007165	signal transduction	TAS	10092583

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for AKT3

Browse Small Molecules at Sigma-Aldrich

Compounds for AKT3 available from Tocris Bioscience

Compound	Action	CAS number
10-DEBC hydrochloride	Selective Akt/PKB inhibitor	[201788-90-1]
API-2	Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral	[35943-35-2]
FPA 124	Akt/PKB inhibitor	[902779-59-3]

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3 Novoseek chemical compound relationships for AKT3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylinositol	56.26	2	10187787 (1)
threonine	55.66	1	11387345 (1)
lipid	0.00	1	10419456 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AKT3)
		Millipore RNAi Products for the Analysis of AKT3 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (AKT3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005465

Sigma-Aldrich siRNA and siRNA Panels for AKT3

Sigma-Aldrich shRNA Panels and shRNA for AKT3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005465 NM_181690

REFSEQ mRNAs for AKT3 gene (2 alternative transcripts):

NM_005465.3 NM_181690.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005465 NM_181690

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005465
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005465
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_005465

Additional cDNA sequence:

AF085234.1 AF124141.1 AF135794.1 AJ245709.1 AK055109.1 AK308052.1 AL080074.1 AL117525.1

AY005799.1 BC019085.2 BC020479.1 BC121154.2 U79271.1

12 DOTS entries:

DT.456229 DT.100779293 DT.444498 DT.95169925 DT.95169929 DT.408249 DT.70103881 DT.207558

DT.91966549 DT.95169930 DT.97859779 DT.427466

24/301 AceView cDNA sequences (see all 301 ):

BM722611 AL117525 BM671327 BM679254 BM714561 AI074114 BQ100974 BF476021

AA134107 BM722084 BX481572 BF793776 AA829894 BQ100736 BM666408 CA867967

BC019085 NM_181690 BM714984 BX504095 AW948952 AL080074 N27253 BQ890571

highest scoring ESTs for AKT3:

AA381040 AA780156 AF085234 AF124141 AJ245709 AL117525 AW960221 AY005799 BC020479 AA028079

Unigene Cluster for AKT3:

V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

Hs.498292 [show with all ESTs]

Unigene Representative Sequence: NM_005465

GeneLoc Exon Structure

6 Ensembl transcripts including schematic representations:

ENST00000391845 ENST00000336199 ENST00000366540 ENST00000263826 ENST00000391844 ENST00000366539

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AKT3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AKT3

¹ / ² / ³

14 probe-sets matching AKT3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
87279_at²^{, 3}	U95-E	1	0.94	1.00	0.76	0.88	AA780156	0.80	1.00	0.91	1
83997_r_at²^{, 3}	U95-E	1	0.31	1.00	0.35	1.27	AI939442	0.40	1.00	0.76	1
80409_at²^{, 3}	U95-D	1	0.31	1.00	0.02	0.75	AI937218	0.60	1.00	0.82	1
40781_at*²^{, 3}	U95-A	1	0.81	1.00	0.74	1.16	U79271	0.60	1.00	0.82	1
219393_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005465	0.60	1.00	0.82	1
222880_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF135794	0.60	1.00	0.82	1
212607_at²^{, 3}	U133-A	1	1.00	1.00	--	--	N32526	0.60	1.00	0.82	1
224229_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL117525	0.80	1.00	0.91	1
212609_s_at*²^{, 3}	U133-A	1	1.00	1.00	--	--	U79271	0.60	1.00	0.82	1
219393_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222880_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212607_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224229_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212609_s_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AKT3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGGGTAACT

SOURCE GeneReport for Unigene cluster: Hs.498292
UniProtKB/Swiss-Prot: AKT3_HUMAN, Q9Y243
Tissue specificity: In adult tissues, it is highly expressed in brain, lung and kidney, but weakly
in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and
not at all in kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AKT3 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AKT3¹	--	v-akt murine thymoma viral oncogene homolog 3 (protein more	95.27(n) 99.58(a)	442964 XM_547496.2 XP_547496.2
rat (Rattus norvegicus)	Akt3¹	--	v-akt murine thymoma viral oncogene homolog 3 (protein more	94.09(n) 99.56(a)	29414 NM_031575.1 NP_113763.1
mouse (Mus musculus)	Akt3^{1, 5}	1⁵	thymoma viral proto-oncogene 3^{1, 5}	93.95(n)¹ 99.16(a)¹	23797¹ NM_011785.2¹ NP_035915.2¹ AA387194⁵ AF124142⁵ (see all 12)
chicken (Gallus gallus)	AKT3¹	--	v-akt murine thymoma viral oncogene homolog 3 (protein more	90.05(n) 99.58(a)	421497 XM_419544.2 XP_419544.1
zebrafish (Danio rerio)	LOC560549¹	--	similar to RAC-gamma serine/threonine-protein kinase more	80.1(n) 95.82(a)	560549 XM_001922486.1 XP_001922521.1

About this table Species with no ortholog for AKT3

ENSEMBL Gene Tree for AKT3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AKT3 gene

AKT1² AKT2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1249 NCBI SNPs in AKT3 are shown (see all 1249 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 353)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs9428966^1,2	F,H	241734523(+)	`GGGCTT/GCTTCT`	2	--	ut3¹ int¹		3	EA WA	298
	rs7521027^1,2	F,H	241732959(+)	`CAAGAC/AAACTT`	2	--	ng5¹ int¹ ese³		4	EU EA WA	420
	rs11588441^1,2	H	242074986(+)	`ACATAG/TCAGTT`	2	--	ng3¹		4	EU EA WA	408
	rs2275521^1,2	H	241733541(-)	`TTTCTC/GCTTCA`	2	--	ut3¹ int¹ ese³ trp³		4	EU EA WA	416
	rs167661^1,2	A,C,F,H,O	241894929(+)	`TATGGA/TTCTCC`	2	--	int¹		8	MN EU EA WA NA	744
	rs1458021^1,2	A,C,F,H,O	241968593(+)	`ATGAAT/CAGATA`	2	--	int¹		20	NS MN EA NA EU WA	1526
	rs1379700^1,2	A,C,F,H,O	241976025(+)	`TTTTTT/CACTTT`	2	--	int¹		11	MN EU EA WA NA	1202
--	rs1531244^1,2	A,C,F,H	242006593(-)	`tcttcT/Cgtaaa`	2	--	int¹ trp³		7	EU EA WA NA	530
	rs2345994^1,2	A,C,F,H	241998898(+)	`aaataT/Caaatc`	2	--	int¹		4	EU EA WA	368
	rs2291410^1,2	A,C,F,H	241783277(-)	`TGCACG/TTTATG`	2	--	int¹		9	EA EU WA NA	2260

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HapMap Linkage Disequilibrium images for AKT3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 611223

8 Novoseek disease relationships for AKT3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
skin cancer	38.03	1	18813315 (1)
ovarian cancer	37.54	4	17178867 (3)
metastatic melanoma	33.84	1	15466193 (1)
melanoma	32.32	28	18451171 (7), 15466193 (6), 17440074 (5), 18813315 (3) (see all 5)
tumors	24.27	20	15466193 (3), 18451171 (2), 10419456 (2), 17440074 (2) (see all 9)
cancer	22.71	5	18813315 (2), 17047397 (1), 16552185 (1), 18392055 (1)
breast cancer	11.94	4	10419456 (4)
prostate cancer	0.00	5	10419456 (3), 16721361 (2)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/79 PubMed articles for AKT3 gene (see all 79 ):

Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site. (PubMed id 10208883)^{1, 2, 3, 4} Nakatani K....Roth R.A. (1999)
A human protein kinase B gamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. (PubMed id 10092583)^{2, 3, 4} Brodbeck D.... Hemmings B.A. (1999)
Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3. (PubMed id 10491192)^{1, 3, 4} Masure S.... Richardson A. (1999)
Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PubMed id 11707444)^{1, 3, 4} Laine J....Noguchi M. (2002)
Two splice variants of PKB gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site Ser-472 in the C-terminal hydrophobic domain. (PubMed id 11387345)^{1, 3, 4} Brodbeck D.... Hemmings B.A. (2001)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{3, 4} Wiemann S.... Poustka A. (2001)
Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. (PubMed id 9512493)^{3, 4} Walker K.S.... Alessi D.R. (1998)
Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. (PubMed id 10419456)^{1, 3} Nakatani K....Roth R.A. (1999)
Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development. (PubMed id 18451171)^{1, 3} Cheung M....Robertson G.P. (2008)
A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition. (PubMed id 17178867)^{1, 3} Cristiano B.E....Pearson R.B. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10000	HGNC: 393	AceView: AKT3	Ensembl:ENSG00000117020	euGenes: HUgn10000
ECgene: AKT3	H-InvDB: AKT3

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for AKT3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for AKT3
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for AKT3 gene:

	Salk Institute:	Protein Kinase B/AKT Modulators and Methods of Use Thereof
	Tufts University:	Regulation of Oncogenesis by Akt-Specific Isoforms

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AKT3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AKT3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AKT3		Antibodies for AKT3
	Explore super-pooled esiRNAs		Proteins for AKT3
	Lentivirus-delivered shRNAs for AKT3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (AKT3)
	Antibodies (AKT3)
	Chimera RNAi (AKT3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for AKT3

	Recombinant Proteins (AKT3, AKT1/2/3, AKT1/3)
	Antibodies (AKT3, AKT1/2/3, AKT1/3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for AKT3

	Drugs/Proteins for AKT3
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for AKT3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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AKT3 Gene at Home site.
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AKT3 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for AKT3

Summaries
for AKT3

Genomic Location
for AKT3

Proteins
for AKT3

Protein Domains/
Families
for AKT3

Gene Function
for AKT3

Pathways & Interactions
for AKT3

Drugs & Compounds
for AKT3

Transcripts
for AKT3

Expression
for AKT3

Orthologs
for AKT3

Paralogs
for AKT3

SNPs/Variants
for AKT3

Disorders & Mutations
for AKT3

Medical News
for AKT3

Publications
for AKT3

Search for AKT3

Genome Databases showing AKT3

Other Databases showing AKT3

Specialized Databases showing AKT3

Licensable Technologies
for AKT3

Services
for AKT3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AKT3 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor AKT3

Summariesfor AKT3

Genomic Locationfor AKT3

Proteinsfor AKT3

Protein Domains/Familiesfor AKT3

Gene Functionfor AKT3

Pathways & Interactionsfor AKT3

Drugs & Compoundsfor AKT3

Transcriptsfor AKT3

Expression for AKT3

Orthologsfor AKT3

Paralogsfor AKT3

SNPs/Variantsfor AKT3

Disorders & Mutationsfor AKT3

Medical Newsfor AKT3

Publicationsfor AKT3

Search for AKT3

Genome Databases showing AKT3

Other Databases showing AKT3

Specialized Databases showing AKT3

Licensable Technologiesfor AKT3

Servicesfor AKT3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AKT3

Summaries
for AKT3

Genomic Location
for AKT3

Proteins
for AKT3

Protein Domains/
Families
for AKT3

Gene Function
for AKT3

Pathways & Interactions
for AKT3

Drugs & Compounds
for AKT3

Transcripts
for AKT3

Expression
for AKT3

Orthologs
for AKT3

Paralogs
for AKT3

SNPs/Variants
for AKT3

Disorders & Mutations
for AKT3

Medical News
for AKT3

Publications
for AKT3

Licensable Technologies
for AKT3

Services
for AKT3