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AKT3 Gene

protein-coding   GIFtS: 74
GCID: GC01M243653

V-Akt Murine Thymoma Viral Oncogene Homolog 3

  See AKT3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Akt Murine Thymoma Viral Oncogene Homolog 31 2     PKB-GAMMA2
PKBG2 3 5     PRKBG2
RAC-PK-gamma2 3     RAC-gamma2
STK-22 3     RAC-Gamma Serine/Threonine Protein Kinase2
PKB Gamma2 3     RAC-Gamma Serine/Threonine-Protein Kinase2
EC 2.7.11.13 8     V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma)2
MPPH2 5     Protein Kinase Akt-33
gamma1     Protein Kinase B Gamma3
Protein Kinase B1     EC 2.7.118

External Ids:    HGNC: 3931   Entrez Gene: 100002   Ensembl: ENSG000001170207   OMIM: 6112235   UniProtKB: Q9Y2433   

Export aliases for AKT3 gene to outside databases

Previous GC identifers: GC01M241568 GC01M238913 GC01M239853 GC01M240598 GC01M239977 GC01M241718 GC01M214031


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AKT3 Gene:
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family.
AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are
involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis,
tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by
platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice
transcript variants encoding distinct isoforms have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for AKT3 Gene:
AKT3 (v-akt murine thymoma viral oncogene homolog 3) is a protein-coding gene. Diseases associated with AKT3 include hemimegalencephaly, and megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot: AKT3_HUMAN, Q9Y243
Function: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT
kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and
angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream
substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity
has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is
crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation
and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth
factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression
of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis

summary for AKT3 Gene:
Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival,
insulin signaling, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway,
resulting in the recruitment of Akt to the plasma membrane via the PH (plexstrin homology domain) of Akt.
Akt is fully activated by phosphorylation at two key sites: Ser308 (phosphorylated by PDK1) and Thr478
(phosphorylated by mTOR and DNA-PK). Akt can then phosphorylated a wide range of substrates including
transcription factors (e.g. FOXO1), kinases (GSK-3, Raf-1, ASK, Chk1) and other proteins with important
signaling roles (e.g. Bad, MDM2). There are three isoforms of Akt; Akt 1, 2 and 3 (also known as PKBalpha,
beta and gamma).

Gene Wiki entry for AKT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_167186.2  NT_187519.1  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AKT3 gene promoter:
         MEF-2A   FAC1   Sp1   POU3F2   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): AKT3 promoter sequence
   Search Chromatin IP Primers for AKT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

AKT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKT3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M243653:  view genomic region     (about GC identifiers)

Start:
243,651,535 bp from pter      End:
244,014,381 bp from pter
Size:
362,847 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AKT3_HUMAN, Q9Y243 (See protein sequence)
Recommended Name: RAC-gamma serine/threonine-protein kinase  
Size: 479 amino acids; 55775 Da
Subunit: Interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation. Interacts with
TRAF6
Caution: In light of strong homologies in the primary amino acid sequence, the 3 AKT kinases were long surmised to
play redundant and overlapping roles. More recent studies has brought into question the redundancy within AKT
kinase isoforms and instead pointed to isoform specific functions in different cellular events and diseases. AKT1
is more specifically involved in cellular survival pathways, by inhibiting apoptotic processes; whereas AKT2 is
more specific for the insulin receptor signaling pathway. Moreover, while AKT1 and AKT2 are often implicated in
many aspects of cellular transformation, the 2 isoforms act in a complementary opposing manner. The role of AKT3
is less clear, though it appears to be predominantly expressed in brain
1 PDB 3D structure from and Proteopedia for AKT3:
2X18 (3D)    
Secondary accessions: Q0VAA6 Q5VTI1 Q5VTI2 Q96QV3 Q9UFP5
Alternative splicing: 2 isoforms:  Q9Y243-1   Q9Y243-2   

Explore the universe of human proteins at neXtProt for AKT3: NX_Q9Y243

Explore proteomics data for AKT3 at MOPED

Post-translational modifications: 

  • Phosphorylation on Thr-305 and Ser-472 is required for full activity (By similarity)1
  • Ubiquitinated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination
    catalyzed by TTC3, leading to its degradation by the proteasome1
  • O-GlcNAcylation at Thr-302 and Thr-309 inhibits activating phosphorylation at Thr-305 via disrupting the
    interaction between AKT and PDK1 (By similarity)1
  • Ubiquitination2 at Lys273
  • Glycosylation2 at Thr302, Thr309
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for AKT3 (Q9Y243) (see all 33)
     YYAMKIL  GVVMYEM  AEIVSAL  IKITDFG 


    See AKT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001193658.1  NP_005456.1  NP_859029.1  

    ENSEMBL proteins: 
     ENSP00000336943   ENSP00000355498   ENSP00000355497   ENSP00000447820   ENSP00000263826  
    Reactome Protein details: Q9Y243

    AKT3 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant AKT3 Protein
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    Enzo Life Sciences proteins for AKT3
    OriGene Purified Proteins for AKT3
    OriGene Protein Over-expression Lysate for AKT3
    OriGene MassSpec for AKT3
    OriGene Custom Protein Services for AKT3
    GenScript Custom Purified and Recombinant Proteins Services for AKT3
    Novus Biologicals AKT3 Proteins
    Novus Biologicals AKT3 Lysates
    Sino Biological Recombinant Protein for AKT3
    Sino Biological Cell Lysate for AKT3
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for AKT3 

     
    antibodies-online proteins for AKT3 (8 products) 

     
    antibodies-online peptides for AKT3

    AKT3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of AKT3
    R&D Systems Antibodies for AKT3
    Cell Signaling Technology (CST) Antibodies for AKT3 
    OriGene Antibodies for AKT3
    OriGene Custom Antibody Services for AKT3
    Novus Biologicals AKT3 Antibodies
    Abcam antibodies for AKT3 (P31749, Q9Y243)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for AKT3
    LSBio Antibodies in human, mouse, rat for AKT3
    antibodies-online antibodies for AKT3 (166 products) 

    AKT3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AKT3
    R&D Systems ELISAs for AKT3         (see all)
    GenScript AKT3-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for AKT3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for AKT3 
    antibodies-online kits for AKT3 (27 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
    Protein kinase B

    Selected InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry Q9Y243

    ProtoNet protein and cluster: Q9Y243

    2 Blocks protein domains:
    IPB000961 Protein kinase C-terminal domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: AKT3_HUMAN, Q9Y243
    Domain: Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to
    the plasma membrane
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with AKT3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKT3_HUMAN, Q9Y243
    Function: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT
    kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and
    angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream
    substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity
    has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is
    crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation
    and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth
    factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression
    of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Two specific sites, one in the kinase domain (Thr-305) and the other in the C-terminal
    regulatory region (Ser-472), need to be phosphorylated for its full activation (By similarity). IGF-1 leads to
    the activation of AKT3, which may play a role in regulating cell survival
    Biophysicochemical properties: Kinetic parameters: KM=87.9 uM for ATP (for purified and in vitro activated AKT3);
    KM=12.4 uM for peptide substrate (for purified and in vitro activated AKT3); KM=118.7 uM for ATP (for recombinant
    myristoylated AKT3 expressed and immunoprecipitated from Rat-1 cells); KM=2.3 uM for peptide substrate (for
    recombinant myristoylated AKT3 expressed and immunoprecipitated from Rat-1 cells);

         Genatlas biochemistry entry for AKT3:
    V-akt murine thymoma viral oncogen homolog 3,general mediator of cell survival,induced by insulin growth factor
    1,AKT3 and others,widely expressed but not in liver and skeletal muscle

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10092583
    GO:0004674protein serine/threonine kinase activity IDA16540465
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI19713527
    GO:0005524ATP binding IDA16540465
         
    Find genes that share ontologies with AKT3           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for AKT3:
     Cell cycle / mitosis defect  Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased mitotic index 

         12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Akt3):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system  normal 
     reproductive system  tumorigenesis 

    Find genes that share phenotypes with AKT3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for AKT3: Akt3tm1Mbb Akt3tm1Hem

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AKT3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AKT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AKT3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AKT3

    miRNA
    Products:
        
    miRTarBase miRNAs that target AKT3:
    hsa-mir-15a-5p (MIRT003334), hsa-mir-16-5p (MIRT003329), hsa-mir-146b-5p (MIRT041618), hsa-mir-124-3p (MIRT022432), hsa-mir-122-5p (MIRT003099), hsa-mir-519d-3p (MIRT006197), hsa-mir-29c-3p (MIRT020391)

    Block miRNA regulation of human, mouse, rat AKT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AKT3 (see all 89):
    hsa-miR-124* hsa-miR-520f hsa-miR-1321 hsa-miR-106a hsa-miR-15a hsa-miR-3653 hsa-miR-519a hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidAKT3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AKT3
    Predesigned siRNA for gene silencing in human, mouse, rat AKT3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AKT3

    Clone
    Products:
         
    OriGene clones in human, mouse for AKT3 (see all 13)
    OriGene ORF clones in mouse, rat for AKT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): AKT3 (NM_005465)
    Sino Biological Human cDNA Clone for AKT3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKT3
    Addgene plasmids for AKT3 

    Cell Line
    Products:
         
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKT3

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12098) for AKT3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AKT3_HUMAN, Q9Y243: Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after
    cell stimulation leading to its translocation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    plasma membrane4
    cytosol3
    extracellular1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with AKT3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AKT3 About   (see all 123)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF signaling pathway0.39
    Immune response BCR pathway0.43
    VEGF - VEGF R2 Signaling Pathways0.35
    Fc epsilon RI signaling pathway0.41
    2Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    Immune response IL 4 signaling pathway0.39
    3Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    HGF Pathway0.34
    4ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    5Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Cell adhesion PLAU signaling0.35
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Transcription PPAR Pathway0.34
    Transcription Receptor mediated HIF regulation0.51
    Development Growth hormone signaling via PI3K AKT and MAPK cascades0.34
    Translation Regulation activity of EIF20.47
    mTOR signaling pathway0.34


    Find genes that share SuperPaths with AKT3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for AKT3 (see all 12)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AKT3 (see all 35)
        LT-BetaR Pathway
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    TRKA Signaling
    PI3K Signaling in B-Lymphocyte

    1 Cell Signaling Technology (CST) Pathway for AKT3
        PI3K / Akt Signaling

    Selected Tocris Bioscience Pathways for AKT3 (see all 8)
        Akt Pathway
    Insulin Pathway
    Toll-like Receptor Pathway
    Apoptosis Pathway
    TGF-beta Pathway

    Selected GeneGo (Thomson Reuters) Pathways for AKT3 (see all 69)
        Development A2A receptor signaling
    Development CNTF receptor signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Signal transduction AKT signaling

    Selected BioSystems Pathways for AKT3 (see all 11)
        MAPK signaling pathway
    Focal Adhesion
    Integrin-mediated cell adhesion
    Signal Transduction of S1P Receptor
    DNA damage response (only ATM dependent)

    Selected Sino Biological Pathways for AKT3 (see all 6)
        TNF Signaling
    EGFR Signaling Pathway
    p53 Pathway
    VEGF Signaling
    Death Receptor Signaling

    Selected Reactome Pathways for AKT3 (see all 12)
        AKT phosphorylates targets in the cytosol
    AKT phosphorylates targets in the nucleus
    AKT-mediated inactivation of FOXO1A
    Activation of BAD and translocation to mitochondria
    Downregulation of ERBB2:ERBB3 signaling

    3 PharmGKB Pathways for AKT3
        EGFR Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for AKT3) (see all 55):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AKT3 (see all 7): 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Insulin Resistance in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AKT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AKT3 (Q9Y2432, 3 ENSP000002638264) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP3P425742, 3, ENSP000003110324MINT-4820732 I2D: score=2 STRING: ENSP00000311032
    PRKCZQ055133, ENSP000003678304I2D: score=4 STRING: ENSP00000367830
    PDPK1O155303, ENSP000003442204I2D: score=2 STRING: ENSP00000344220
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    TSC2P498153, ENSP000002194764I2D: score=2 STRING: ENSP00000219476
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000002mitochondrial genome maintenance IMP18524868
    GO:0006468protein phosphorylation TAS10092583
    GO:0007165signal transduction IMP18524868

    Find genes that share ontologies with AKT3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for AKT3 (see all 12)     About this table
    CompoundAction CAS #
    A-674563potent selective protein kinase B/Akt inhibitor[552325-73-2]
    AT7867potent ATP-competitive inhibitor of Akt1, Akt2 and Akt3[857531-00-1]
    AZD5363Orally bioavailable, selective and potent inhibitor of all PKB/AKT iso-forms[1143532-39-1]
    BX795Cell-permeable, ATP-competitive and reversible PDK1 inhibitor[702675-74-9]
    CCT128930novel potent ATP-competitive AKT inhibitor[885499-61-6]
    GDC-0068 (RG7440)Akt inhibitor[1001264-89-6]
    GSK690693Potent, ATP-competitive pan-Akt inhibitor[937174-76-0]
    MK-2206 dihydrochloridea highly selective non-ATP competitive allosteric Akt inhibitor[1032350-13-2]
    Palomid 529novel potent antitumour PI3K/Akt/mTOR inhibitor[914913-88-5]
    PerifosineAKT inhibitor[157716-52-4]

    Compounds for AKT3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    10-DEBC hydrochlorideSelective Akt/PKB inhibitor[201788-90-1]
    API-2Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral[35943-35-2]
    FPA 124Akt/PKB inhibitor[902779-59-3]
    API-1Selective Akt/PKB inhibitor. Antitumor[36707-00-3]
    SC 79Akt activator[305834-79-1]

    2 HMDB Compounds for AKT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    5 Novoseek inferred chemical compound relationships for AKT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ly294002 68 1 11322783 (1)
    phosphatidylinositol 57.5 2 10187787 (1)
    threonine 51.9 1 11387345 (1)
    serine 44.6 6 10208883 (3), 19401561 (1), 11387345 (1)
    lipid 0 1 10419456 (1)



    Find genes that share compounds with AKT3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for AKT3 gene (3 alternative transcripts): 
    NM_001206729.1  NM_005465.4  NM_181690.2  

    Unigene Cluster for AKT3:

    V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
    Hs.498292  [show with all ESTs]
    Unigene Representative Sequence: NM_005465
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336199(uc001hzz.1) ENST00000366540(uc021plu.1) ENST00000366539(uc001iab.2)
    ENST00000492957 ENST00000552631 ENST00000463991 ENST00000491219 ENST00000490018
    ENST00000550388 ENST00000263826
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate AKT3 (see all 89):
    hsa-miR-124* hsa-miR-520f hsa-miR-1321 hsa-miR-106a hsa-miR-15a hsa-miR-3653 hsa-miR-519a hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidAKT3 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 3): AKT3 (NM_005465)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKT3
    Addgene plasmids for AKT3 
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12098) for AKT3 

    Additional mRNA sequence: 

    AF085234.1 AF124141.1 AF135794.1 AJ245709.1 AK055109.1 AK308052.1 AL080074.1 AL117525.1 
    AY005799.1 BC019085.2 BC020479.1 BC121154.2 U79271.1 

    15 DOTS entries:

    DT.456229  DT.100779293  DT.444498  DT.95169925  DT.95169929  DT.408249  DT.427466  DT.70103881 
    DT.92438232  DT.86856078  DT.207558  DT.91966549  DT.92062989  DT.95169930  DT.97859779 

    Selected AceView cDNA sequences (see all 301):

    BF476021 BM450091 BI491093 NM_181690 AV705889 BQ084082 R69631 W72147 
    BQ100707 N28376 BM693993 BU785650 BU790247 AL080074 BM714561 AI148323 
    AI348454 BG035303 AW264381 AJ245709 F35739 CB129928 AA249299 CA943632 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AKT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGGTAACT
    AKT3 Expression
    About this image


    AKT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Liver (Hepatobiliary System)
             Liver Bud
    AKT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.498292

    UniProtKB/Swiss-Prot: AKT3_HUMAN, Q9Y243
    Tissue specificity: In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart,
    testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AKT3 (see all 7): 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Insulin Resistance in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AKT3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akt31 , 5 thymoma viral proto-oncogene 31, 5 94.08(n)1
    99.58(a)1
      1 (82.66 cM)5
    237971  NM_011785.31  NP_035915.31 
     1770200735 
    chicken
    (Gallus gallus)
    Aves AKT31 v-akt murine thymoma viral oncogene homolog 3 (protein more 90.05(n)
    99.58(a)
      421497  XM_419544.4  XP_419544.1 
    lizard
    (Anolis carolinensis)
    Reptilia AKT36
    v-akt murine thymoma viral oncogene homolog 3
    100(a)
    1 ↔ 1
    GL343285.1(492046-659629)
    zebrafish
    (Danio rerio)
    Actinopterygii akt3a1 v-akt murine thymoma viral oncogene homolog 3a 80.17(n)
    95.82(a)
      560549  NM_001197201.2  NP_001184130.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Akt13 anti-apoptosis protein serine/threonine
    kinase
    63(a)   89B6   --
    worm
    (Caenorhabditis elegans)
    Secernentea akt-13 PH (pleckstrin homology) domain,
    Protein kinase more
    53(a)
    (best of 2)
      V(10251544-10255039)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SCH96
    Protein kinase involved in transcriptional activat...
    23(a)
    1 → many
    VIII(509363-511837) YHR205W


    ENSEMBL Gene Tree for AKT3 (if available)
    TreeFam Gene Tree for AKT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AKT3 gene
    AKT12  GRK72  RPS6KB12  GRK12  SGK32  GRK42  GRK62  C8orf44-SGK32  
    SGK22  ADRBK22  SGK12  RPS6KB22  GRK52  ADRBK12  AKT22  
    Selected SIMAP similar genes for AKT3 using alignment to 3 protein entries:     AKT3_HUMAN (see all proteins) (see all similar genes):
    AKT1    AKT2    SGK2    PRKCH    PKN1    PRKCZ
    KIN27    PRKACB    RPS6KB1    MARK4    PRKCE    PRKACA
    PRKCB    PRKCI    RPS6KA5    RPS6KA2    RPS6KA1    PRKCA

    Find genes that share paralogs with AKT3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AKT3 (see all 6122)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0692604
    Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH)4--see VAR_0692602 N S mis40--------
    VAR_0403584
    A glioblastoma multiforme sample4--see VAR_0403582 G R mis40--------
    VAR_0658304
    Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH)4--see VAR_0658302 E K mis40--------
    VAR_0692614
    Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH)4--see VAR_0692612 R W mis40--------
    rs107190171,2
    C,F--214087127(+) TCTTCT/-TTTTT 3 -- int1 trp33Minor allele frequency- -:0.50NA CSA 6
    rs1508230551,2
    C--214127658(+) AGAAG-/AAAAAA 3 -- int10--------
    rs1116183571,2
    C,F--214156652(+) GAATCG/ACTTGA 3 -- int11Minor allele frequency- A:0.50WA 2
    rs113867121,2
    C--214216294(+) TTTTTT/-TTTTT 3 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs2015724591,2
    --214229316(+) TATAT-/AT    
       ATATA
    TTTTT
    3 -- int10--------
    rs1998452691,2
    --214229318(+) TATAT-/ATATA 
            
    TTTTT
    3 -- int10--------

    HapMap Linkage Disequilibrium report for AKT3 (243651535 - 243901535 bp, first 250kb of AKT3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AKT3 (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677365CNV Deletion23128226
    esv2606093CNV Deletion19546169
    esv2182482CNV Deletion18987734
    esv5138CNV Deletion18987735
    esv2726518CNV Deletion23290073
    nsv821560CNV Deletion20802225
    esv2674959CNV Deletion23128226
    esv2648270CNV Deletion19546169
    esv2575701CNV Insertion19546169
    nsv509724CNV Insertion20534489

    Human Gene Mutation Database (HGMD): AKT3
    2 Site Specific Mutation Identification with PCR Assays for AKT3:
    Cosmic IdAA Change
    48227p.Q124L
    13303p.G171R
    2 Site Specific Cancer Mutation PCR Panels containing AKT3:
    PI3K-PTEN Pathway
    Cancer Comprehensive Panel 384HT
    1 Copy Number PCR Panel containing AKT3:
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing AKT3
    DNA2.0 Custom Variant and Variant Library Synthesis for AKT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 611223   
    OMIM disorders: 603387  
    UniProtKB/Swiss-Prot: AKT3_HUMAN, Q9Y243
  • Note=AKT3 is a key modulator of several tumors like melanoma, glioma and ovarian cancer. Active AKT3
    increases progressively during melanoma tumor progression with highest levels present in advanced-stage
    metastatic melanomas. Promotes melanoma tumorigenesis by decreasing apoptosis. Plays a key role in the genesis of
    ovarian cancers through modulation of G2/M phase transition. With AKT2, plays a pivotal role in the biology of
    glioblastoma
  • Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH) [MIM:603387]: A syndrome
    characterized by megalencephaly, hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is
    considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 7 diseases for AKT3:    
    About MalaCards
    hemimegalencephaly    megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome    megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome, somatic    thymoma
    naxos disease    corpus callosum agenesis    megalencephaly


    Find genes that share disorders with AKT3           About GenesLikeMe

    8 Novoseek inferred disease relationships for AKT3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    skin cancer 33.2 1 18813315 (1)
    ovarian cancer 32.7 4 17178867 (3)
    melanoma 32.2 29 18451171 (7), 15466193 (6), 17440074 (5), 18813315 (3) (see all 6)
    tumors 31.5 20 15466193 (3), 18451171 (2), 10419456 (2), 17440074 (2) (see all 9)
    metastatic melanoma 29.1 1 15466193 (1)
    cancer 27.6 6 18813315 (2), 17047397 (1), 16552185 (1), 18392055 (1) (see all 5)
    breast cancer 12.3 5 10419456 (4), 20102399 (1)
    prostate cancer 2.37 7 10419456 (3), 20102399 (2), 16721361 (2)

    Genetic Association Database (GAD): AKT3
    Human Genome Epidemiology (HuGE) Navigator: AKT3 (9 documents)

    Export disorders for AKT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AKT3 gene, integrated from 10 sources (see all 152):
    (articles sorted by number of sources associating them with AKT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site. (PubMed id 10208883)1, 2, 3, 9 Nakatani K.... Roth R.A. (Biochem. Biophys. Res. Commun. 1999)
    2. A human protein kinase B gamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. (PubMed id 10092583)1, 2, 3 Brodbeck D.... Hemmings B.A. (J. Biol. Chem. 1999)
    3. A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition. (PubMed id 17178867)1, 2, 9 Cristiano B.E.... Pearson R.B. (Cancer Res. 2006)
    4. Deregulated Akt3 activity promotes development of malignant melanoma. (PubMed id 15466193)1, 2, 9 Stahl J.M.... Robertson G.P. (Cancer Res. 2004)
    5. Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3. (PubMed id 10491192)1, 2, 9 Masure S.... Richardson A. (Eur. J. Biochem. 1999)
    6. Akt2 and Akt3 play a pivotal role in malignant gliomas. (PubMed id 20167810)1, 2, 9 Mure H.... Nagahiro S. (Neuro-oncol. 2010)
    7. A novel AKT3 mutation in melanoma tumours and cell lines. (PubMed id 18813315)1, 2, 9 Davies M.A.... Mills G.B. (Br. J. Cancer 2008)
    8. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PubMed id 11707444)1, 2, 9 Laine J.... Noguchi M. (J. Biol. Chem. 2002)
    9. Two splice variants of PKB gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site Ser-472 in the C-terminal hydrophobic domain. (PubMed id 11387345)1, 2, 9 Brodbeck D.... Hemmings B.A. (J. Biol. Chem. 2001)
    10. Mutational and immunohistochemical study of the PI3K/Akt pathway in papillary thyroid carcinoma in Greece. (PubMed id 20186503)1, 4, 9 Sozopoulos E....Tseleni-Balafouta S. (Endocr. Pathol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10000 HGNC: 393 AceView: AKT3 Ensembl:ENSG00000117020 euGenes: HUgn10000
    ECgene: AKT3 Kegg: 10000 H-InvDB: AKT3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AKT3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AKT3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AKT3 gene:
    Search GeneIP for patents involving AKT3

    Licensable Technologies for AKT3 gene:
     Salk Institute: Protein Kinase B/AKT Modulators and Methods of Use Thereof
     Tufts University:  Regulation of Oncogenesis by Akt-Specific Isoforms
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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