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Aliases for AKT2 Gene

Aliases for AKT2 Gene

  • V-Akt Murine Thymoma Viral Oncogene Homolog 2 2 3
  • Protein Kinase B Beta 3 4
  • Protein Kinase Akt-2 3 4
  • RAC-PK-Beta 3 4
  • EC 2.7.11.1 4 63
  • PKB Beta 3 4
  • HIHGHH 3 6
  • RAC-Beta Serine/Threonine-Protein Kinase 3
  • Murine Thymoma Viral (V-Akt) Homolog-2 3
  • Rac Protein Kinase Beta 3
  • EC 2.7.11 63
  • RAC-BETA 3
  • PKBBETA 3
  • PRKBB 3
  • PKBB 3

External Ids for AKT2 Gene

Previous GeneCards Identifiers for AKT2 Gene

  • GC19M041377
  • GC19M041129
  • GC19M045414
  • GC19M045431
  • GC19M045430
  • GC19M040736
  • GC19M037171

Summaries for AKT2 Gene

Entrez Gene Summary for AKT2 Gene

  • This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKT2 Gene

AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2) is a Protein Coding gene. Diseases associated with AKT2 include hypoinsulinemic hypoglycemia with hemihypertrophy and hypoinsulinemic hypoglycemia and body hemihypertrophy. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include protein serine/threonine kinase activity and kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot for AKT2 Gene

  • AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at Ser-50 negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at Ser-21 and GSK3B at Ser-9, resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of Ser-83 decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at Ser-939 and Thr-1462, thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at Thr-24, Ser-256 and Ser-319. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates Ser-454 on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of Ser-273, resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on Ser-318, which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development

  • One of the few specific substrates of AKT2 identified recently is PITX2. Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake. Phosphorylates C2CD5 on Ser-197 during insulin-stimulated adipocytes. AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. Phosphorylates CLK2 on Thr-343

Tocris Summary for AKT2 Gene

  • Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, insulin signaling, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway, resulting in the recruitment of Akt to the plasma membrane via the PH (plexstrin homology domain) of Akt. Akt is fully activated by phosphorylation at two key sites: Ser308 (phosphorylated by PDK1) and Thr478 (phosphorylated by mTOR and DNA-PK). Akt can then phosphorylated a wide range of substrates including transcription factors (e.g. FOXO1), kinases (GSK-3, Raf-1, ASK, Chk1) and other proteins with important signaling roles (e.g. Bad, MDM2). There are three isoforms of Akt; Akt 1, 2 and 3 (also known as PKBalpha, beta and gamma).

Gene Wiki entry for AKT2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKT2 Gene

Genomics for AKT2 Gene

Regulatory Elements for AKT2 Gene

Genomic Location for AKT2 Gene

Start:
40,230,317 bp from pter
End:
40,285,536 bp from pter
Size:
55,220 bases
Orientation:
Minus strand

Genomic View for AKT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKT2 Gene

Proteins for AKT2 Gene

  • Protein details for AKT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31751-AKT2_HUMAN
    Recommended name:
    RAC-beta serine/threonine-protein kinase
    Protein Accession:
    P31751
    Secondary Accessions:
    • B2RBD8
    • Q05BV0
    • Q0VAN0
    • Q0VAN1
    • Q68GC0

    Protein attributes for AKT2 Gene

    Size:
    481 amino acids
    Molecular mass:
    55769 Da
    Quaternary structure:
    • Interacts with BTBD10 (By similarity). Interacts with KCTD20 (By similarity). Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with CLK2, PBH2 and TRAF6. Interacts (when phosphorylated) with CLIP3, the interaction promotes cell membrane localization (PubMed:19139280).

    Three dimensional structures from OCA and Proteopedia for AKT2 Gene

    Alternative splice isoforms for AKT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKT2 Gene

Proteomics data for AKT2 Gene at MOPED

Post-translational modifications for AKT2 Gene

  • O-GlcNAcylation at Thr-306 and Thr-313 inhibits activating phosphorylation at Thr-309 via disrupting the interaction between AKT and PDK1.
  • Phosphorylation on Thr-309 and Ser-474 is required for full activity.
  • Ubiquitinated; undergoes both Lys-48- and Lys-63-linked polyubiquitination. TRAF6-induced Lys-63-linked AKT2 ubiquitination. When fully phosphorylated and translocated into the nucleus, undergoes Lys-48-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome.
  • Ubiquitination at Lys30 and Lys378
  • Glycosylation at Ser128, Ser131, Thr306, and Thr313
  • Modification sites at PhosphoSitePlus

Domains for AKT2 Gene

Gene Families for AKT2 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P31751

UniProtKB/Swiss-Prot:

AKT2_HUMAN :
  • P31751
Domain:
  • Binding of the PH domain to phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) following phosphatidylinositol 3-kinase alpha (PIK3CA) activity results in its targeting to the plasma membrane
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
genes like me logo Genes that share domains with AKT2: view

Function for AKT2 Gene

Molecular function for AKT2 Gene

GENATLAS Biochemistry: V-akt murine thymoma viral oncogen homolog 2,general mediator of cell survival induced by insulin growth factor 1,AKT2 and others,activated by phosphatidylinositol 3-
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=358.4 uM for ATP (for purified and in vitro activated AKT2) {ECO:0000269 PubMed:16540465}; KM=3.4 uM for peptide substrate (for purified and in vitro activated AKT2) {ECO:0000269 PubMed:16540465}; KM=564 uM for ATP (for recombinant myristoylated AKT2 expressed and immunoprecipitated from Rat-1 cells) {ECO:0000269 PubMed:16540465}; KM=2.3 uM for peptide substrate (for recombinant myristoylated AKT2 expressed and immunoprecipitated from Rat-1 cells) {ECO:0000269 PubMed:16540465};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Two specific sites, one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation. Aminofurazans are potent AKT2 inhibitors.
UniProtKB/Swiss-Prot Function: AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at Ser-50 negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at Ser-21 and GSK3B at Ser-9, resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of Ser-83 decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at Ser-939 and Thr-1462, thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at Thr-24, Ser-256 and Ser-319. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates Ser-454 on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of Ser-273, resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on Ser-318, which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development
UniProtKB/Swiss-Prot Function: One of the few specific substrates of AKT2 identified recently is PITX2. Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake. Phosphorylates C2CD5 on Ser-197 during insulin-stimulated adipocytes. AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. Phosphorylates CLK2 on Thr-343

Enzyme Numbers (IUBMB) for AKT2 Gene

Gene Ontology (GO) - Molecular Function for AKT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS 21432781
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 10490823
GO:0005524 ATP binding IDA 16540465
genes like me logo Genes that share ontologies with AKT2: view
genes like me logo Genes that share phenotypes with AKT2: view

Animal Models for AKT2 Gene

MGI Knock Outs for AKT2:

No data available for Transcription Factor Targeting and HOMER Transcription for AKT2 Gene

Localization for AKT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKT2 Gene

Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKT2 Gene COMPARTMENTS Subcellular localization image for AKT2 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4
mitochondrion 2
cytoskeleton 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AKT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 21432781
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS 21432781
GO:0005938 cell cortex ISS --
genes like me logo Genes that share ontologies with AKT2: view

Pathways for AKT2 Gene

SuperPathways for AKT2 Gene

Superpath Contained pathways
1 PI-3K cascade
2 Signaling by FGFR
3 Insulin receptor signalling cascade
4 Translation Insulin regulation of translation
5 IL-9 Signaling Pathways
genes like me logo Genes that share pathways with AKT2: view

Pathways by source for AKT2 Gene

Gene Ontology (GO) - Biological Process for AKT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0005978 glycogen biosynthetic process IEA --
GO:0006006 glucose metabolic process IEA --
GO:0006417 regulation of translation IEA --
GO:0006464 cellular protein modification process TAS 1409633
genes like me logo Genes that share ontologies with AKT2: view

Compounds for AKT2 Gene

(12) ApexBio Compounds for AKT2 Gene

Compound Action Cas Number
A-674563 potent selective protein kinase B/Akt inhibitor. [552325-73-2]
AT7867 potent ATP-competitive inhibitor of Akt1, Akt2 and Akt3 [857531-00-1]
AZD5363 Orally bioavailable, selective and potent inhibitor of all PKB/AKT iso-forms [1143532-39-1]
BX795 Cell-permeable, ATP-competitive and reversible PDK1 inhibitor [702675-74-9]
CCT128930 novel potent ATP-competitive AKT inhibitor [885499-61-6]
GDC-0068 (RG7440) Akt inhibitor [1001264-89-6]
GSK690693 Potent, ATP-competitive pan-Akt inhibitor [937174-76-0]
MK-2206 dihydrochloride a highly selective non-ATP competitive allosteric Akt inhibitor [1032350-13-2]
Palomid 529 novel potent antitumour PI3K/Akt/mTOR inhibitor. [914913-88-5]
Perifosine AKT inhibitor [157716-52-4]
PHT-427 pleckstrin homology domain inhibitor with dual Akt and PKB Kinase (PDPK1) inhibitory activity [1191951-57-1]
Triciribine suppresses the phosphorylation level and kinase activity of Akt. [35943-35-2]

(5) Tocris Compounds for AKT2 Gene

Compound Action Cas Number
10-DEBC hydrochloride Selective Akt/PKB inhibitor [925681-41-0]
API-1 Selective Akt/PKB inhibitor. Antitumor [36707-00-3]
API-2 Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral [35943-35-2]
FPA 124 Akt/PKB inhibitor [902779-59-3]
SC 79 Akt activator [305834-79-1]

(2) HMDB Compounds for AKT2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(16) Novoseek inferred chemical compound relationships for AKT2 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylinositol 76.9 21
ly294002 68.4 2
threonine 67.1 13
serine 56.9 11
rapamycin 52.8 4
genes like me logo Genes that share compounds with AKT2: view

Transcripts for AKT2 Gene

Unigene Clusters for AKT2 Gene

V-akt murine thymoma viral oncogene homolog 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKT2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - - - -
SP4:
SP5: - - - - - - - - -
SP6: - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - - - - - - -
SP13: - - - - - - - -
SP14: -
SP15:
SP16:

ExUns: 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b · 24c ^ 25
SP1: - - - -
SP2: -
SP3:
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: - -
SP11: - - -
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for AKT2 Gene

GeneLoc Exon Structure for
AKT2
ECgene alternative splicing isoforms for
AKT2

Expression for AKT2 Gene

mRNA expression in normal human tissues for AKT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKT2 Gene

SOURCE GeneReport for Unigene cluster for AKT2 Gene Hs.631535

mRNA Expression by UniProt/SwissProt for AKT2 Gene

P31751-AKT2_HUMAN
Tissue specificity: Expressed in all cell types so far analyzed
genes like me logo Genes that share expressions with AKT2: view

No data available for mRNA differential expression in normal tissues for AKT2 Gene

Orthologs for AKT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AKT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKT2 35
  • 99.17 (n)
  • 99.79 (a)
AKT2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AKT2 35
  • 92.38 (n)
  • 98.75 (a)
AKT2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKT2 35
  • 91.89 (n)
  • 97.61 (a)
AKT2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akt2 35
  • 90.51 (n)
  • 98.13 (a)
Akt2 16
Akt2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AKT2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKT2 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akt2 35
  • 90.85 (n)
  • 97.71 (a)
lizard
(Anolis carolinensis)
Reptilia AKT2 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia akt2 35
  • 73.67 (n)
  • 87.94 (a)
zebrafish
(Danio rerio)
Actinopterygii akt2 35
  • 75.3 (n)
  • 86.64 (a)
akt2 36
  • 86 (a)
OneToMany
akt2l 36
  • 76 (a)
OneToMany
Dr.11393 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002161 35
  • 67.31 (n)
  • 65.17 (a)
fruit fly
(Drosophila melanogaster)
Insecta Akt1 35
  • 62.45 (n)
  • 63.92 (a)
Akt1 36
  • 49 (a)
OneToMany
Akt1 37
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea akt-1 36
  • 50 (a)
ManyToMany
akt-2 36
  • 48 (a)
ManyToMany
F28C10.3 37
  • 35 (a)
akt-1 37
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCH9 36
  • 22 (a)
OneToMany
SCH9 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9149 36
  • 60 (a)
OneToMany
Species with no ortholog for AKT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AKT2 Gene

ENSEMBL:
Gene Tree for AKT2 (if available)
TreeFam:
Gene Tree for AKT2 (if available)

Paralogs for AKT2 Gene

genes like me logo Genes that share paralogs with AKT2: view

Variants for AKT2 Gene

Sequence variations from dbSNP and Humsavar for AKT2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs748236 -- 40,267,403(+) TGTTA(C/T)GCTTC intron-variant, upstream-variant-2KB
rs873143 -- 40,267,411(+) TTCTG(C/T)CACTC intron-variant, upstream-variant-2KB
rs892118 -- 40,268,346(-) GGCGC(C/T)AGGCA intron-variant, upstream-variant-2KB
rs892119 -- 40,254,165(-) AATCA(A/G)AAGAG intron-variant
rs892120 -- 40,253,753(-) AGTGA(A/G)ATAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKT2 Gene

Variant ID Type Subtype PubMed ID
dgv1083e1 CNV Complex 17122850
nsv911699 CNV Loss 21882294
esv2718561 CNV Deletion 23290073
esv2718563 CNV Deletion 23290073
esv1037738 CNV Deletion 17803354
esv1005660 CNV Deletion 20482838

Relevant External Links for AKT2 Gene

HapMap Linkage Disequilibrium report
AKT2
Human Gene Mutation Database (HGMD)
AKT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKT2 Gene

Disorders for AKT2 Gene

(2) OMIM Diseases for AKT2 Gene (164731)

UniProtKB/Swiss-Prot

AKT2_HUMAN
  • Note=Defects in AKT2 are a cause of susceptibility to breast cancer (BC). AKT2 promotes metastasis of tumor cells without affecting the latency of tumor development. With AKT3, plays also a pivotal role in the biology of glioblastoma.
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:15166380, ECO:0000269 PubMed:19164855}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hypoinsulinemic hypoglycemia with hemihypertrophy (HIHGHH) [MIM:240900]: A disorder characterized by hypoglycemia, low insulin levels, low serum levels of ketone bodies and branched-chain amino acids, left-sided hemihypertrophy, neonatal macrosomia, reduced consciousness and hypoglycemic seizures. {ECO:0000269 PubMed:21979934}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for AKT2 Gene

(22) Novoseek inferred disease relationships for AKT2 Gene

Disease -log(P) Hits PubMed IDs
ovarian cancer 64.1 22
pancreatic cancer 50.7 12
ovarian carcinoma 45.8 10
cancer 42.8 26
tumors 42.6 36

Relevant External Links for AKT2

Genetic Association Database (GAD)
AKT2
Human Genome Epidemiology (HuGE) Navigator
AKT2
Tumor Gene Database (TGDB):
AKT2
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Publications for AKT2 Gene

  1. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. (PMID: 1409633) Cheng J.Q. … Testa J.R. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 23
  2. A family with severe insulin resistance and diabetes due to a mutation in AKT2. (PMID: 15166380) George S. … Barroso I. (Science 2004) 3 4 23
  3. Analysis of genetic variation in Akt2/PKB-beta in severe insulin resistance, lipodystrophy, type 2 diabetes, and related metabolic phenotypes. (PMID: 17327441) Tan K. … Barroso I. (Diabetes 2007) 3 23 48
  4. Akt2 Gene common allelic variants in insulin resistance and the metabolic syndrome. (PMID: 17576055) Tassi V. … Trischitta V. (Nutr Metab Cardiovasc Dis 2008) 3 23 48
  5. First evidence of genetic association between AKT2 and polycystic ovary syndrome. (PMID: 18768676) Goodarzi M.O. … Azziz R. (Diabetes Care 2008) 3 23 48

Products for AKT2 Gene

  • Addgene plasmids for AKT2

Sources for AKT2 Gene

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