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AKT2 Gene

protein-coding   GIFtS: 80
GCID: GC19M040736

V-Akt Murine Thymoma Viral Oncogene Homolog 2

  See AKT2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Akt Murine Thymoma Viral Oncogene Homolog 21 2     PKBBETA2
Protein Kinase Akt-22 3     PRKBB2
Protein Kinase B Beta2 3     RAC-BETA2
RAC-PK-beta2 3     Murine Thymoma Viral (V-Akt) Homolog-22
PKB Beta2 3     Rac Protein Kinase Beta2
EC 2.7.11.13 8     RAC-Beta Serine/Threonine-Protein Kinase2
HIHGHH2 5     EC 2.7.118
PKBB2     

External Ids:    HGNC: 3921   Entrez Gene: 2082   Ensembl: ENSG000001052217   OMIM: 1647315   UniProtKB: P317513   

Export aliases for AKT2 gene to outside databases

Previous GC identifers: GC19M041377 GC19M041129 GC19M045414 GC19M045431 GC19M045430 GC19M037171


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

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Entrez Gene summary for AKT2 Gene:
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases
containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8
ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant
phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable
of phophorylating several known proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for AKT2 Gene:
AKT2 (v-akt murine thymoma viral oncogene homolog 2) is a protein-coding gene. Diseases associated with AKT2 include hypoinsulinemic hypoglycemia with hemihypertrophy, and thymoma. GO annotations related to this gene include protein serine/threonine kinase activity and kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot: AKT2_HUMAN, P31751
Function: AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT
kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and
angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream
substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity
has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced
translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50'
negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the
attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory
14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of
glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in
inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by
which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis
signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative
stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2
at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1
and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead
family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In
particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on
equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and
positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The
phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of
pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby
potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide
phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition
of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho
GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell
proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling
the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron
positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase
(PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF),
epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic
effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and
disassembly. May be involved in the regulation of the placental development
Function: One of the few specific substrates of AKT2 identified recently is PITX2. Phosphorylation of PITX2
impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2
seems also to be the principal isoform responsible of the regulation of glucose uptake. Phosphorylates C2CD5 on
'Ser-197' during insulin-stimulated adipocytes. AKT2 is also specifically involved in skeletal muscle
differentiation, one of its substrates in this process being ANKRD2. Down-regulation by RNA interference reduces
the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
Phosphorylates CLK2 on 'Thr-343'

summary for AKT2 Gene:
Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival,
insulin signaling, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway,
resulting in the recruitment of Akt to the plasma membrane via the PH (plexstrin homology domain) of Akt.
Akt is fully activated by phosphorylation at two key sites: Ser308 (phosphorylated by PDK1) and Thr478
(phosphorylated by mTOR and DNA-PK). Akt can then phosphorylated a wide range of substrates including
transcription factors (e.g. FOXO1), kinases (GSK-3, Raf-1, ASK, Chk1) and other proteins with important
signaling roles (e.g. Bad, MDM2). There are three isoforms of Akt; Akt 1, 2 and 3 (also known as PKBalpha,
beta and gamma).

Gene Wiki entry for AKT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AKT2 gene promoter:
         c-Fos   AP-1   ATF-2   p300   CREB   deltaCREB   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAKT2 promoter sequence
   Search Chromatin IP Primers for AKT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1-q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1-q13.2

AKT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKT2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M040736:  view genomic region     (about GC identifiers)

Start:
40,736,224 bp from pter      End:
40,791,443 bp from pter
Size:
55,220 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AKT2_HUMAN, P31751 (See protein sequence)
Recommended Name: RAC-beta serine/threonine-protein kinase  
Size: 481 amino acids; 55769 Da
Subunit: Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with CLK2, PBH2 and TRAF6. Interacts
(when phosphorylated) with CLIP3, the interaction promotes cell membrane localization
Caution: In light of strong homologies in the primary amino acid sequence, the 3 AKT kinases were long surmised to
play redundant and overlapping roles. More recent studies has brought into question the redundancy within AKT
kinase isoforms and instead pointed to isoform specific functions in different cellular events and diseases. AKT1
is more specifically involved in cellular survival pathways, by inhibiting apoptotic processes; whereas AKT2 is
more specific for the insulin receptor signaling pathway. Moreover, while AKT1 and AKT2 are often implicated in
many aspects of cellular transformation, the 2 isoforms act in a complementary opposing manner. The role of AKT3
is less clear, though it appears to be predominantly expressed in brain
Selected PDB 3D structures from and Proteopedia for AKT2 (see all 17):
1GZK (3D)        1GZN (3D)        1GZO (3D)        1MRV (3D)        1MRY (3D)        1O6K (3D)    
Secondary accessions: B2RBD8 Q05BV0 Q0VAN1 Q68GC0

Explore the universe of human proteins at neXtProt for AKT2: NX_P31751

Explore proteomics data for AKT2 at MOPED

Post-translational modifications: 

  • Phosphorylation on Thr-309 and Ser-474 is required for full activity1
  • Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. TRAF6-induced 'Lys-63'-linked AKT2
    ubiquitination. When fully phosphorylated and translocated into the nucleus, undergoes
    'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome1
  • O-GlcNAcylation at Thr-306 and Thr-313 inhibits activating phosphorylation at Thr-309 via disrupting the
    interaction between AKT and PDK1 (By similarity)1
  • Ubiquitination2 at Lys30, Lys378
  • Glycosylation2 at Ser128, Ser131, Thr306, Thr313
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for AKT2 (P31751) (see all 33)
     RDIKLEN  TPPDRYD  YYAMKIL  GVVMYEM 


    See AKT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001229956.1  NP_001229957.1  NP_001617.1  

    ENSEMBL proteins: 
     ENSP00000375892   ENSP00000470822   ENSP00000375719   ENSP00000463368   ENSP00000462469  
     ENSP00000309428   ENSP00000472382   ENSP00000471369   ENSP00000463262   ENSP00000462919  
     ENSP00000472371   ENSP00000462776   ENSP00000463086   ENSP00000396968   ENSP00000463686  
     ENSP00000470604   ENSP00000404083   ENSP00000375891   ENSP00000407999   ENSP00000462022  
     ENSP00000403842   ENSP00000351095   ENSP00000396532   ENSP00000462715   ENSP00000463806  
     ENSP00000392458   ENSP00000403890   ENSP00000399532  
    Reactome Protein details: P31751

    AKT2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant AKT2 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for AKT2
    OriGene Purified Protein for AKT2
    OriGene Protein Over-expression Lysate for AKT2
    OriGene MassSpec for AKT2
    OriGene Custom Protein Services for AKT2
    GenScript Custom Purified and Recombinant Proteins Services for AKT2
    Novus Biologicals AKT2 Proteins
    Novus Biologicals AKT2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for AKT2 

     
    antibodies-online proteins for AKT2 (8 products) 

     
    antibodies-online peptides for AKT2

    AKT2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of AKT2
    R&D Systems Antibodies for AKT2
    Cell Signaling Technology (CST) Antibodies for AKT2 
    OriGene Antibodies for AKT2
    OriGene Custom Antibody Services for AKT2
    Novus Biologicals AKT2 Antibodies
    Abcam antibodies for AKT2 (P31751, P31749)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for AKT2
    antibodies-online antibodies for AKT2 (264 products) 

    AKT2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AKT2
    R&D Systems ELISAs for AKT2         (see all)
    GenScript Custom Assay Services for AKT2
    Cell Signaling Technology (CST) Sandwich ELISA Kits for AKT2
    Enzo Life Sciences assays for AKT2
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for AKT2 
    antibodies-online kits for AKT2 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: v-akt murine thymoma viral oncogene homolog 2
    Protein kinase B

    Selected InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry P31751

    ProtoNet protein and cluster: P31751

    2 Blocks protein domains:
    IPB000961 Protein kinase C-terminal domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: AKT2_HUMAN, P31751
    Domain: Binding of the PH domain to phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) following
    phosphatidylinositol 3-kinase alpha (PIK3CA) activity results in its targeting to the plasma membrane
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with AKT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKT2_HUMAN, P31751
    Function: AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT
    kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and
    angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream
    substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity
    has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced
    translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50'
    negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the
    attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory
    14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of
    glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in
    inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by
    which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis
    signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative
    stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2
    at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1
    and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead
    family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In
    particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on
    equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and
    positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The
    phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of
    pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby
    potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide
    phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition
    of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho
    GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell
    proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling
    the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron
    positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase
    (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF),
    epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic
    effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and
    disassembly. May be involved in the regulation of the placental development
    Function: One of the few specific substrates of AKT2 identified recently is PITX2. Phosphorylation of PITX2
    impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2
    seems also to be the principal isoform responsible of the regulation of glucose uptake. Phosphorylates C2CD5 on
    'Ser-197' during insulin-stimulated adipocytes. AKT2 is also specifically involved in skeletal muscle
    differentiation, one of its substrates in this process being ANKRD2. Down-regulation by RNA interference reduces
    the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
    Phosphorylates CLK2 on 'Thr-343'
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Two specific sites, one in the kinase domain (Thr-309) and the other in the C-terminal
    regulatory region (Ser-474), need to be phosphorylated for its full activation. Aminofurazans are potent AKT2
    inhibitors
    Biophysicochemical properties: Kinetic parameters: KM=358.4 uM for ATP (for purified and in vitro activated AKT2);
    KM=3.4 uM for peptide substrate (for purified and in vitro activated AKT2); KM=564 uM for ATP (for recombinant
    myristoylated AKT2 expressed and immunoprecipitated from Rat-1 cells); KM=2.3 uM for peptide substrate (for
    recombinant myristoylated AKT2 expressed and immunoprecipitated from Rat-1 cells);

         Genatlas biochemistry entry for AKT2:
    V-akt murine thymoma viral oncogen homolog 2,general mediator of cell survival induced by insulin growth factor
    1,AKT2 and others,activated by phosphatidylinositol 3-

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI10490823
    GO:0005524ATP binding IDA16540465
         
    Find genes that share ontologies with AKT2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for AKT2:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased apoptosis  Increased cell transformation 
     Increased mitotic index 

         Selected MGI mutant phenotypes (inferred from 5 alleles(MGI details for Akt2) (see all 18):
     adipose tissue  cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     muscle  nervous system  no phenotypic analysis  normal  reproductive system 

    Find genes that share phenotypes with AKT2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for AKT2: Akt2tm1Rsg Akt2tm1Hem Akt2tm1.1Mbb

       genOway: Develop your customized and physiologically relevant rodent model for AKT2

    miRNA
    Products:
        
    miRTarBase miRNAs that target AKT2:
    hsa-mir-149-5p (MIRT045569), hsa-mir-877-3p (MIRT036895), hsa-mir-124-3p (MIRT022768), hsa-mir-1296-5p (MIRT036081), hsa-mir-423-3p (MIRT042572), hsa-mir-184 (MIRT000425), hsa-mir-744-5p (MIRT037571), hsa-mir-708-5p (MIRT006473), hsa-mir-21-5p (MIRT031019)

    Block miRNA regulation of human, mouse, rat AKT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AKT2 (see all 51):
    hsa-let-7d hsa-miR-429 hsa-miR-3678-5p hsa-miR-650 hsa-let-7g hsa-miR-3667-5p hsa-miR-124 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidAKT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AKT2
    Predesigned siRNA for gene silencing in human, mouse, rat AKT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AKT2

    Clone
    Products:
         
    OriGene clones in human, mouse for AKT2 (see all 9)
    OriGene ORF clones in mouse, rat for AKT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AKT2 (NM_001626)
    Sino Biological Human cDNA Clone for AKT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKT2
    Addgene plasmids for AKT2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKT2

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12296) for AKT2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    AKT2_HUMAN, P31751: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Localizes within both
    nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary
    myoblasts. By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containing
    increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol4
    mitochondrion2
    cytoskeleton1
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0005938cell cortex ISS--
    GO:0030027lamellipodium ----

    Find genes that share ontologies with AKT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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    SuperPaths for AKT2 About   (see all 135)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF signaling pathway0.39
    Immune response BCR pathway0.43
    VEGF - VEGF R2 Signaling Pathways0.35
    Fc epsilon RI signaling pathway0.41
    2Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    Immune response IL 4 signaling pathway0.39
    3Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    HGF Pathway0.34
    4Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Cell adhesion PLAU signaling0.35
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Transcription PPAR Pathway0.34
    Transcription Receptor mediated HIF regulation0.51
    Development Growth hormone signaling via PI3K AKT and MAPK cascades0.34
    Translation Regulation activity of EIF20.47
    mTOR signaling pathway0.34
    5IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-15 Signaling Pathways0.88
    IL-7 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-21 Signaling Pathways0.90
    Development Thrombopoietin regulated cell processes0.38
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    Adipocytokines and Insulin Signaling0.34


    Find genes that share SuperPaths with AKT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for AKT2 (see all 12)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AKT2 (see all 35)
        LT-BetaR Pathway
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    TRKA Signaling
    PI3K Signaling in B-Lymphocyte

    2 Cell Signaling Technology (CST) Pathways for AKT2
        PI3K / Akt Signaling
    Glucose / Energy Metabolism

    Selected Tocris Bioscience Pathways for AKT2 (see all 8)
        Akt Pathway
    Insulin Pathway
    Toll-like Receptor Pathway
    Apoptosis Pathway
    TGF-beta Pathway

    Selected GeneGo (Thomson Reuters) Pathways for AKT2 (see all 69)
        Development A2A receptor signaling
    Development CNTF receptor signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Signal transduction AKT signaling

    Selected BioSystems Pathways for AKT2 (see all 20)
        MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Integrin-mediated cell adhesion
    Signal Transduction of S1P Receptor

    Selected Sino Biological Pathways for AKT2 (see all 6)
        TNF Signaling
    EGFR Signaling Pathway
    p53 Pathway
    VEGF Signaling
    Death Receptor Signaling

    Selected Reactome Pathways for AKT2 (see all 17)
        deactivation of the beta-catenin transactivating complex
    AKT phosphorylates targets in the nucleus
    AKT-mediated inactivation of FOXO1A
    Activation of PKB
    Downregulation of ERBB2:ERBB3 signaling

    2 PharmGKB Pathways for AKT2
        EGFR Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for AKT2) (see all 55):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AKT2 (see all 9): 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              VEGF Signaling in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AKT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AKT2 (P317511, 2, 3 ENSP000003758924) via UniProtKB, MINT, STRING, and/or I2D (see all 147)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498411, 3, ENSP000003248064EBI-296058,EBI-373586 I2D: score=5 STRING: ENSP00000324806
    CASP3P425742, 3, ENSP000003110324MINT-4820707 I2D: score=2 STRING: ENSP00000311032
    APPL1Q9UKG13, ENSP000002882664I2D: score=4 STRING: ENSP00000288266
    CHUKO151113, ENSP000003594244I2D: score=4 STRING: ENSP00000359424
    FOXO4P981773, ENSP000003633774I2D: score=2 STRING: ENSP00000363377
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation ISS--
    GO:0005978glycogen biosynthetic process IEA--
    GO:0006006glucose metabolic process IEA--
    GO:0006417regulation of translation IEA--
    GO:0006464cellular protein modification process TAS1409633

    Find genes that share ontologies with AKT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for AKT2 (see all 12)     About this table
    CompoundAction CAS #
    A-674563potent selective protein kinase B/Akt inhibitor[552325-73-2]
    AT7867potent ATP-competitive inhibitor of Akt1, Akt2 and Akt3[857531-00-1]
    AZD5363Orally bioavailable, selective and potent inhibitor of all PKB/AKT iso-forms[1143532-39-1]
    BX795Cell-permeable, ATP-competitive and reversible PDK1 inhibitor[702675-74-9]
    CCT128930novel potent ATP-competitive AKT inhibitor[885499-61-6]
    GDC-0068 (RG7440)Akt inhibitor[1001264-89-6]
    GSK690693Potent, ATP-competitive pan-Akt inhibitor[937174-76-0]
    MK-2206 dihydrochloridea highly selective non-ATP competitive allosteric Akt inhibitor[1032350-13-2]
    Palomid 529novel potent antitumour PI3K/Akt/mTOR inhibitor[914913-88-5]
    PerifosineAKT inhibitor[157716-52-4]

    Compounds for AKT2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    10-DEBC hydrochlorideSelective Akt/PKB inhibitor[201788-90-1]
    API-2Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral[35943-35-2]
    FPA 124Akt/PKB inhibitor[902779-59-3]
    API-1Selective Akt/PKB inhibitor. Antitumor[36707-00-3]
    SC 79Akt activator[305834-79-1]

    2 HMDB Compounds for AKT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    4 DrugBank Compounds for AKT2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE-- --target--10592235
    4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE-- --target--10592235
    ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE-- --target--10592235
    N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for AKT2 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 76.9 30 9679957 (3), 12048203 (2), 15082758 (1), 16095999 (1) (see all 18)
    ly294002 68.4 3 17849421 (1), 18171600 (1)
    threonine 67.1 14 1409633 (3), 19861406 (1), 7566964 (1), 19270695 (1) (see all 11)
    serine 56.9 13 17804734 (2), 19861406 (1), 19270695 (1), 17311912 (1) (see all 10)
    rapamycin 52.8 5 17908691 (3), 15713898 (1)
    wortmannin 51.1 6 9679957 (2), 9712142 (2), 11507039 (1)
    glycogen 42.8 7 9712142 (2), 10446150 (1), 17021050 (1)
    cisplatin 26.6 26 15350374 (3), 12697749 (3), 14612499 (2), 18788627 (2) (see all 6)
    paclitaxel 24.8 11 17332325 (2), 18842333 (2), 20407875 (2), 10769688 (1) (see all 5)
    glucose 23.6 23 20203102 (3), 17021050 (3), 17576055 (1), 18972094 (1) (see all 14)



    Find genes that share compounds with AKT2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for AKT2 gene (3 alternative transcripts): 
    NM_001243027.2  NM_001243028.2  NM_001626.5  

    Unigene Cluster for AKT2:

    V-akt murine thymoma viral oncogene homolog 2
    Hs.631535  [show with all ESTs]
    Unigene Representative Sequence: NM_001626
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 42):
    ENST00000392038(uc002one.3 uc010egs.3 uc002onf.3 uc010xvj.2 uc010egt.3)
    ENST00000483166 ENST00000476266 ENST00000489375 ENST00000391844 ENST00000496089
    ENST00000476247 ENST00000584288 ENST00000311278 ENST00000497948 ENST00000579047(uc010egu.2)
    ENST00000578615 ENST00000391845 ENST00000486647 ENST00000578282 ENST00000579345
    ENST00000480878 ENST00000580878
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AKT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AKT2 (see all 51):
    hsa-let-7d hsa-miR-429 hsa-miR-3678-5p hsa-miR-650 hsa-let-7g hsa-miR-3667-5p hsa-miR-124 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidAKT2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AKT2
    Predesigned siRNA for gene silencing in human, mouse, rat AKT2
    Clone
    Products:
         
    OriGene clones in human, mouse for AKT2 (see all 9)
    OriGene ORF clones in mouse, rat for AKT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AKT2 (NM_001626)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKT2
    Addgene plasmids for AKT2 
    Primer
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    OriGene qPCR primer pairs and template standards for AKT2
    OriGene qSTAR qPCR primer pairs in human, mouse for AKT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AKT2
      QuantiTect SYBR Green Assays in human, mouse, rat AKT2
      QuantiFast Probe-based Assays in human, mouse, rat AKT2
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12296) for AKT2 

    Additional mRNA sequence: 

    AK054771.1 AK055779.1 AK098099.1 AK122839.1 AK294453.1 AK304209.1 AK308006.1 AK308906.1 
    AK314619.1 BC022779.1 BC032709.1 BC040028.1 BC063421.1 BC120994.1 BC120995.1 BC127856.1 
    M77198.1 M95936.1 

    Selected DOTS entries (see all 40):

    DT.100800195  DT.97860143  DT.100800189  DT.118043  DT.95258547  DT.95314444  DT.86841526  DT.100800196 
    DT.87015983  DT.95233305  DT.121643439  DT.95258561  DT.91854020  DT.121409985  DT.102843087  DT.95258562 
    DT.121410002  DT.95251898  DT.100800199  DT.100800200  DT.121409952  DT.121409961  DT.86839008  DT.91784301 

    Selected AceView cDNA sequences (see all 376):

    BM929828 BX954130 AW027538 M79014 AI283491 AI197948 AI197839 BQ962885 
    CK724891 AI082336 AW449482 AA421068 BF109550 AI886883 AI568587 AI675180 
    AW027245 BQ219902 AW571615 BU589608 CA453915 BF733046 BM905688 CA448265 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AKT2 (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
    SP1:              -     -     -     -     -     -     -     -     -     -     -     -                                                           -     -         
    SP2:              -     -     -     -     -     -     -     -     -     -     -     -     -                                                     -     -         
    SP3:                                                                          -     -     -                                                     -     -         
    SP4:                                                                                                                                                            
    SP5:                                -     -     -     -     -     -     -     -     -                                                                           

    ExUns: 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b · 24c ^ 25
    SP1:  -                 -           -                 -                                 
    SP2:  -                                                                                 
    SP3:                                                                                    
    SP4:  -                 -           -                                                   
    SP5:                                                                                    


    ECgene alternative splicing isoforms for AKT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    AKT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGGGTGGG
    AKT2 Expression
    About this image


    AKT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    AKT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631535

    UniProtKB/Swiss-Prot: AKT2_HUMAN, P31751
    Tissue specificity: Expressed in all cell types so far analyzed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AKT2 (see all 9): 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              VEGF Signaling in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Diabetes in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat AKT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AKT2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akt21 , 5 thymoma viral proto-oncogene 21, 5 90.51(n)1
    98.13(a)1
      7 (15.94 cM)5
    116521  NM_001110208.11  NP_001103678.11 
     275915525 
    lizard
    (Anolis carolinensis)
    Reptilia AKT26
    v-akt murine thymoma viral oncogene homolog 2
    93(a)
    1 ↔ 1
    LGf(2296158-2311318)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC046261.12   -- 74.76(n)    BC046261.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.113932 Danio rerio mRNA similar to v-akt murine thymoma viral more 78.53(n)    BC046892.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Akt11 , 3 anti-apoptosis protein serine/threonine
    kinase3
    Akt11
    61(a)3
    62.45(n)1
    63.92(a)1
      89B63
    419571  NM_169706.11  NP_732114.11 
    worm
    (Caenorhabditis elegans)
    Secernentea akt-13 PH (pleckstrin homology) domain,
    Protein kinase more
    53(a)
    (best of 2)
      V(10251544-10255039)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SCH9(YHR205W)4 Protein kinase involved in transcriptional activation more   --   8(509363-511837) 856612  NP_012075.1 


    ENSEMBL Gene Tree for AKT2 (if available)
    TreeFam Gene Tree for AKT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AKT2 gene
    AKT12  GRK72  RPS6KB12  GRK12  SGK32  GRK42  GRK62  C8orf44-SGK32  
    SGK22  ADRBK22  AKT32  SGK12  RPS6KB22  GRK52  ADRBK12  
    Selected SIMAP similar genes for AKT2 using alignment to 25 protein entries:     AKT2_HUMAN (see all proteins) (see all similar genes):
    AKT1    AKT3    PKN2    PHKG2    PRKCH    MARK4
    PKN1    PRKCI    SGK2    PRKCD    KIN27    PRKCE
    RPS6KA5    PRKACB    STK38L    RPS6KA2    RPS6KA1    RPS6KA3

    Find genes that share paralogs with AKT2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for AKT2 (see all 1081)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0673094
    Hypoinsulinemic hypoglycemia with hemihypertrophy (HIHGHH)4--see VAR_0673092 E K mis40--------
    VAR_0673104
    Diabetes mellitus, non-insulin-dependent (NIDDM)4--see VAR_0673102 R H mis40--------
    rs105814691,2
    C--40735924(+) TATGCTATT/-  
            
    TATTT
    3 -- int11Minor allele frequency- -:0.50NA 2
    rs1114079031,2
    C--40754718(+) GACAGG/AGAGGA 3 -- int11Minor allele frequency- A:0.50WA 2
    rs1133945951,2
    C--40756316(+) GAGGCG/CTGAGA 3 -- int11Minor allele frequency- C:0.50CSA 2
    rs671349721,2
    C--40758508(+) GGATC-/TCCACCT 3 -- int11Minor allele frequency- TC:0.00NA 2
    rs106893981,2
    C--40759367(+) AGACA-/AGA   
      C
    /GACA
    ATATA
    3 -- int10--------
    rs1139503781,2
    C,F--40760366(+) GGAGGC/TGGAGG 3 -- int11Minor allele frequency- T:0.50WA 2
    rs133465231,2
    C--40763493(+) acacaA/Cacaca 3 -- int12Minor allele frequency- C:0.00NA 4
    rs107133091,2
    C--40765203(+) ATGTGC/-CCAGA 3 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for AKT2 (40736224 - 40791443 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for AKT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718561CNV Deletion23290073
    esv1005660CNV Deletion20482838
    esv2718563CNV Deletion23290073
    esv1037738CNV Deletion17803354
    nsv911699CNV Loss21882294
    dgv1083e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): AKT2
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing AKT2:
    Oncogenes & Tumor Suppressor Genes 384HC
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing AKT2
    DNA2.0 Custom Variant and Variant Library Synthesis for AKT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 164731   
    OMIM disorders: 125853  240900  
    UniProtKB/Swiss-Prot: AKT2_HUMAN, P31751
  • Note=Defects in AKT2 are a cause of susceptibility to breast cancer (BC). AKT2 promotes metastasis of
    tumor cells without affecting the latency of tumor development. With AKT3, plays also a pivotal role in the
    biology of glioblastoma
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose
    homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese
    body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance,
    hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes,
    kidneys, nerves, and blood vessels. Note=The disease is caused by mutations affecting the gene represented in
    this entry
  • Hypoinsulinemic hypoglycemia with hemihypertrophy (HIHGHH) [MIM:240900]: A disorder characterized by
    hypoglycemia, low insulin levels, low serum levels of ketone bodies and branched-chain amino acids, left-sided
    hemihypertrophy, neonatal macrosomia, reduced consciousness and hypoglycemic seizures. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 15 diseases for AKT2:    
    About MalaCards
    hypoinsulinemic hypoglycemia with hemihypertrophy    thymoma    familial partial lipodystrophy due to akt2 mutations    hypertension, insulin resistance-related
    diabetes mellitus, noninsulin-dependent, late onset    diabetes mellitus, type 2, susceptiblity to    diabetes mellitus, noninsulin-dependent, 2    diabetes mellitus, noninsulin-dependent, association with
    diabetes, type 2    ovarian epithelial cancer    warfarin resistance    type 2 diabetes mellitus
    insulin resistance    hemihypertrophy    diabetes mellitus, noninsulin-dependent

    2 diseases from the University of Copenhagen DISEASES database for AKT2:
    Thymoma     Ovarian cancer

    Find genes that share disorders with AKT2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for AKT2 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 64.1 30 10822383 (6), 18842333 (2), 7657393 (2), 12144681 (1) (see all 15)
    pancreatic cancer 50.7 15 8780719 (3), 8622988 (1), 10490823 (1), 9190895 (1) (see all 10)
    ovarian carcinoma 45.8 13 1409633 (4), 7657393 (3), 9712142 (1), 8646743 (1) (see all 5)
    cancer 42.8 32 17047397 (2), 20409325 (2), 18353613 (2), 10594016 (2) (see all 21)
    tumors 42.6 45 17804734 (4), 10822383 (2), 14654898 (2), 16721043 (2) (see all 26)
    insulin resistance 38.4 9 17327441 (2), 17576055 (2), 15166380 (1), 15910615 (1) (see all 6)
    breast cancer 37.1 17 17332325 (3), 18353613 (3), 7657393 (2), 16088978 (1) (see all 10)
    breast carcinoma 35.6 2 11507039 (1), 7657393 (1)
    lipodystrophy 31.5 3 17327441 (1), 16409151 (1), 16722806 (1)
    somatic mutations 28.1 6 17047397 (3), 20354455 (1)

    Genetic Association Database (GAD): AKT2
    Human Genome Epidemiology (HuGE) Navigator: AKT2 (24 documents)
    Tumor Gene Database (TGDB): AKT2

    Export disorders for AKT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AKT2 gene, integrated from 10 sources (see all 359):
    (articles sorted by number of sources associating them with AKT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. (PubMed id 1409633)1, 2, 3, 9 Cheng J.Q.... Testa J.R. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. MEK1 and AKT2 mutations in Japanese lung cancer. (PubMed id 20354455)1, 4, 9 Sasaki H....Fujii Y. (J Thorac Oncol 2010)
    3. Akt2 and Akt3 play a pivotal role in malignant gliomas. (PubMed id 20167810)1, 2, 9 Mure H.... Nagahiro S. (Neuro-oncol. 2010)
    4. Akt2 Gene common allelic variants in insulin resistance and the metabolic syndrome. (PubMed id 17576055)1, 4, 9 Tassi V....Trischitta V. (Nutr Metab Cardiovasc Dis 2008)
    5. First evidence of genetic association between AKT2 and polycystic ovary syndrome. (PubMed id 18768676)1, 4, 9 Goodarzi M.O....Azziz R. (Diabetes Care 2008)
    6. Analysis of genetic variation in Akt2/PKB-beta in severe insulin resistance, lipodystrophy, type 2 diabetes, and related metabolic phenotypes. (PubMed id 17327441)1, 4, 9 Tan K....Barroso I. (Diabetes 2007)
    7. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. (PubMed id 19164214)1, 4, 9 Hildebrandt M.A....Wu X. (J. Clin. Oncol. 2009)
    8. Kinetic mechanism of AKT/PKB enzyme family. (PubMed id 16540465)1, 2, 9 Zhang X....Kendall R.L. (J. Biol. Chem. 2006)
    9. Mutational and immunohistochemical study of the PI3K/Akt pathway in papillary thyroid carcinoma in Greece. (PubMed id 20186503)1, 4, 9 Sozopoulos E....Tseleni-Balafouta S. (Endocr. Pathol. 2010)
    10. A family with severe insulin resistance and diabetes due to a mutation in AKT2. (PubMed id 15166380)1, 2, 9 George S.... Barroso I. (Science 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 208 HGNC: 392 AceView: AKT2 Ensembl:ENSG00000105221 euGenes: HUgn208
    ECgene: AKT2 Kegg: 208 H-InvDB: AKT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AKT2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AKT2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/akt2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AKT2 gene:
    Search GeneIP for patents involving AKT2

    Licensable Technologies for AKT2 gene:
     Salk Institute: Protein Kinase B/AKT Modulators and Methods of Use Thereof
     Tufts University:  Regulation of Oncogenesis by Akt-Specific Isoforms
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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