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Aliases for AKT1 Gene

Aliases for AKT1 Gene

  • V-Akt Murine Thymoma Viral Oncogene Homolog 1 2 3
  • Protein Kinase B Alpha 3 4
  • Proto-Oncogene C-Akt 3 4
  • RAC-PK-Alpha 3 4
  • EC 2.7.11.1 4 64
  • PKB Alpha 3 4
  • CWS6 3 6
  • PKB 3 4
  • RAC 3 4
  • RAC-Alpha Serine/Threonine-Protein Kinase 3
  • Rac Protein Kinase Alpha 3
  • Protein Kinase B 4
  • PKB-ALPHA 3
  • RAC-ALPHA 3
  • EC 2.7.11 64
  • AKT1m 3
  • PRKBA 3
  • AKT 3

External Ids for AKT1 Gene

Summaries for AKT1 Gene

Entrez Gene Summary for AKT1 Gene

  • The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for AKT1 Gene

AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1) is a Protein Coding gene. Diseases associated with AKT1 include cowden syndrome 6 and breast adenocarcinoma. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include identical protein binding and enzyme binding. An important paralog of this gene is GRK6.

UniProtKB/Swiss-Prot for AKT1 Gene

  • AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at Ser-50 negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at Ser-21 and GSK3B at Ser-9, resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of Ser-83 decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at Ser-939 and Thr-1462, thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at Thr-24, Ser-256 and Ser-319. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates Ser-454 on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of Ser-273, resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on Ser-318, which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Phosphorylates STK4/MST1 at Thr-120 and Thr-387 leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at Thr-117 and Thr-384 leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at Ser-259 and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity. Phosphorylates KAT6A at Thr-369 and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53

  • AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at Thr-145 induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation

Tocris Summary for AKT1 Gene

  • Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, insulin signaling, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway, resulting in the recruitment of Akt to the plasma membrane via the PH (plexstrin homology domain) of Akt. Akt is fully activated by phosphorylation at two key sites: Ser308 (phosphorylated by PDK1) and Thr478 (phosphorylated by mTOR and DNA-PK). Akt can then phosphorylated a wide range of substrates including transcription factors (e.g. FOXO1), kinases (GSK-3, Raf-1, ASK, Chk1) and other proteins with important signaling roles (e.g. Bad, MDM2). There are three isoforms of Akt; Akt 1, 2 and 3 (also known as PKBalpha, beta and gamma).

Gene Wiki entry for AKT1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKT1 Gene

Genomics for AKT1 Gene

Genomic Location for AKT1 Gene

Start:
104,769,349 bp from pter
End:
104,795,751 bp from pter
Size:
26,403 bases
Orientation:
Minus strand

Genomic View for AKT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKT1 Gene

Regulatory Elements for AKT1 Gene

Proteins for AKT1 Gene

  • Protein details for AKT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31749-AKT1_HUMAN
    Recommended name:
    RAC-alpha serine/threonine-protein kinase
    Protein Accession:
    P31749
    Secondary Accessions:
    • B2RAM5
    • B7Z5R1
    • Q9BWB6

    Protein attributes for AKT1 Gene

    Size:
    480 amino acids
    Molecular mass:
    55686 Da
    Quaternary structure:
    • Interacts with BTBD10 (By similarity). Interacts with KCTD20 (By similarity). Interacts (via the C-terminus) with CCDC88A (via its C-terminus). Interacts with GRB10; the interaction leads to GRB10 phosphorylation thus promoting YWHAE-binding (By similarity). Interacts with AGAP2 (isoform 2/PIKE-A); the interaction occurs in the presence of guanine nucleotides. Interacts with AKTIP. Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with CDKN1B; the interaction phosphorylates CDKN1B promoting 14-3-3 binding and cell-cycle progression. Interacts with MAP3K5 and TRAF6. Interacts with BAD, PPP2R5B, STK3 and STK4. Interacts (via PH domain) with SIRT1. Interacts with SRPK2 in a phosphorylation-dependent manner. Interacts with RAF1. Interacts with TRIM13; the interaction ubiquitinates AKT1 leading to its proteasomal degradation. Interacts with TNK2 and CLK2. Interacts (via the C-terminus) with THEM4 (via its C-terminus). Interacts with and phosphorylated by PDPK1. Interacts with PA2G4 (By similarity). Interacts with KIF14; the interaction is detected in the plasma membrane upon INS stimulation and promotes AKT1 phosphorylation (PubMed:24784001).

    Three dimensional structures from OCA and Proteopedia for AKT1 Gene

    Alternative splice isoforms for AKT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKT1 Gene

Proteomics data for AKT1 Gene at MOPED

Post-translational modifications for AKT1 Gene

  • Acetylated on Lys-14 and Lys-20 by the histone acetyltransferases EP300 and KAT2B. Acetylation results in reduced phosphorylation and inhibition of activity. Deacetylated at Lys-14 and Lys-20 by SIRT1. SIRT1-mediated deacetylation relieves the inhibition.
  • O-GlcNAcylation at Thr-305 and Thr-312 inhibits activating phosphorylation at Thr-308 via disrupting the interaction between AKT1 and PDPK1. O-GlcNAcylation at Ser-473 also probably interferes with phosphorylation at this site.
  • Phosphorylation on Thr-308, Ser-473 and Tyr-474 is required for full activity. Activated TNK2 phosphorylates it on Tyr-176 resulting in its binding to the anionic plasma membrane phospholipid PA. This phosphorylated form localizes to the cell membrane, where it is targeted by PDPK1 and PDPK2 for further phosphorylations on Thr-308 and Ser-473 leading to its activation. Ser-473 phosphorylation by mTORC2 favors Thr-308 phosphorylation by PDPK1. Phosphorylated at Thr-308 and Ser-473 by IKBKE and TBK1. Ser-473 phosphorylation is enhanced by interaction with AGAP2 isoform 2 (PIKE-A). Ser-473 phosphorylation is enhanced in focal cortical dysplasias with Taylor-type balloon cells. Ser-473 phosphorylation is enhanced by signaling through activated FLT3. Dephosphorylated at Thr-308 and Ser-473 by PP2A phosphatase. The phosphorylated form of PPP2R5B is required for bridging AKT1 with PP2A phosphatase. Ser-473 is dephosphorylated by CPPED1, leading to termination of signaling.
  • Ubiquitinated via Lys-48-linked polyubiquitination by ZNRF1, leading to its degradation by the proteasome (By similarity). Ubiquitinated; undergoes both Lys-48- and Lys-63-linked polyubiquitination. TRAF6-induced Lys-63-linked AKT1 ubiquitination is critical for phosphorylation and activation. When ubiquitinated, it translocates to the plasma membrane, where it becomes phosphorylated. When fully phosphorylated and translocated into the nucleus, undergoes Lys-48-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome. Also ubiquitinated by TRIM13 leading to its proteasomal degradation. Phosphorylated, undergoes Lys-48-linked polyubiquitination preferentially at Lys-284 catalyzed by MUL1, leading to its proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys8, Lys30, Lys39, and Lys276
  • Glycosylation at Ser126, Ser129, Thr305, Thr312, and Ser473

Domains for AKT1 Gene

Gene Families for AKT1 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
IUPHAR :

UniProtKB/Swiss-Prot:

AKT1_HUMAN
Domain:
  • Binding of the PH domain to phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) following phosphatidylinositol 3-kinase alpha (PIK3CA) activity results in its targeting to the plasma membrane. The PH domain mediates interaction with TNK2 and Tyr-176 is also essential for this interaction:
    • P31749
  • The AGC-kinase C-terminal mediates interaction with THEM4:
    • P31749
  • Contains 1 AGC-kinase C-terminal domain.:
    • P31749
  • Contains 1 PH domain.:
    • P31749
  • Contains 1 protein kinase domain.:
    • P31749
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.:
    • P31749
genes like me logo Genes that share domains with AKT1: view

Function for AKT1 Gene

Molecular function for AKT1 Gene

GENATLAS Biochemistry: V-akt murine thymoma viral oncogen homolog 1,general mediator of cell survival induced by insulin growth factor 1,AKT1 and others activated by phosphadidylinositol 3-kinase in the antiapoptotic PIK3 pathway,phosphorylating and inactivating components of the apoptotic machinery including BAD,CASP9 and the transcription factor FKHRL1
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=52.8 uM for ATP (for purified and in vitro activated AKT1) {ECO:0000269 PubMed:16540465}; KM=0.5 uM for peptide substrate (for purified and in vitro activated AKT1) {ECO:0000269 PubMed:16540465}; KM=143.3 uM for ATP (for recombinant myristoylated AKT1 expressed and immunoprecipitated from Rat-1 cells) {ECO:0000269 PubMed:16540465}; KM=2.9 uM for peptide substrate (for recombinant myristoylated AKT1 expressed and immunoprecipitated from Rat-1 cells) {ECO:0000269 PubMed:16540465};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Three specific sites, one in the kinase domain (Thr-308) and the two other ones in the C-terminal regulatory region (Ser-473 and Tyr-474), need to be phosphorylated for its full activation. Inhibited by pyrrolopyrimidine inhibitors like aniline triazole and spiroindoline.
UniProtKB/Swiss-Prot Function: AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at Ser-50 negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at Ser-21 and GSK3B at Ser-9, resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of Ser-83 decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at Ser-939 and Thr-1462, thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at Thr-24, Ser-256 and Ser-319. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates Ser-454 on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of Ser-273, resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on Ser-318, which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Phosphorylates STK4/MST1 at Thr-120 and Thr-387 leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at Thr-117 and Thr-384 leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at Ser-259 and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity. Phosphorylates KAT6A at Thr-369 and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53
UniProtKB/Swiss-Prot Function: AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at Thr-145 induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation

Enzyme Numbers (IUBMB) for AKT1 Gene

Gene Ontology (GO) - Molecular Function for AKT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10570282
GO:0004674 protein serine/threonine kinase activity TAS 21432781
GO:0004712 protein serine/threonine/tyrosine kinase activity IDA 22797923
GO:0004713 protein tyrosine kinase activity --
GO:0005080 protein kinase C binding IEA --
genes like me logo Genes that share ontologies with AKT1: view
genes like me logo Genes that share phenotypes with AKT1: view

Animal Models for AKT1 Gene

MGI Knock Outs for AKT1:

No data available for Transcription Factor Targeting and HOMER Transcription for AKT1 Gene

Localization for AKT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKT1 Gene

Cytoplasm. Nucleus. Cell membrane. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKT1 Gene COMPARTMENTS Subcellular localization image for AKT1 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
cytoskeleton 4
extracellular 3
mitochondrion 3
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 2
vacuole 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for AKT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 21432781
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 21432781
GO:0005739 mitochondrion IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with AKT1: view

Pathways for AKT1 Gene

SuperPathways for AKT1 Gene

Superpath Contained pathways
1 PI-3K cascade
2 Signaling by FGFR
3 Translation Insulin regulation of translation
4 IL-9 Signaling Pathways
5 Apoptotic Pathways in Synovial Fibroblasts
genes like me logo Genes that share pathways with AKT1: view

Pathways by source for AKT1 Gene

Gene Ontology (GO) - Biological Process for AKT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IMP 16280327
GO:0001649 osteoblast differentiation IEA --
GO:0001893 maternal placenta development IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 19057511
GO:0001938 positive regulation of endothelial cell proliferation IMP 19850054
genes like me logo Genes that share ontologies with AKT1: view

Compounds for AKT1 Gene

(12) ApexBio Compounds for AKT1 Gene

Compound Action Cas Number
A-674563 potent selective protein kinase B/Akt inhibitor. [552325-73-2]
AT7867 potent ATP-competitive inhibitor of Akt1, Akt2 and Akt3 [857531-00-1]
AZD5363 Orally bioavailable, selective and potent inhibitor of all PKB/AKT iso-forms [1143532-39-1]
BX795 Cell-permeable, ATP-competitive and reversible PDK1 inhibitor [702675-74-9]
CCT128930 novel potent ATP-competitive AKT inhibitor [885499-61-6]
GDC-0068 (RG7440) Akt inhibitor [1001264-89-6]
GSK690693 Potent, ATP-competitive pan-Akt inhibitor [937174-76-0]
MK-2206 dihydrochloride a highly selective non-ATP competitive allosteric Akt inhibitor [1032350-13-2]
Palomid 529 novel potent antitumour PI3K/Akt/mTOR inhibitor. [914913-88-5]
Perifosine AKT inhibitor [157716-52-4]
PHT-427 pleckstrin homology domain inhibitor with dual Akt and PKB Kinase (PDPK1) inhibitory activity [1191951-57-1]
Triciribine suppresses the phosphorylation level and kinase activity of Akt. [35943-35-2]

(5) Tocris Compounds for AKT1 Gene

Compound Action Cas Number
10-DEBC hydrochloride Selective Akt/PKB inhibitor [201788-90-1]
API-1 Selective Akt/PKB inhibitor. Antitumor [36707-00-3]
API-2 Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral [35943-35-2]
FPA 124 Akt/PKB inhibitor [902779-59-3]
SC 79 Akt activator [305834-79-1]

(3) HMDB Compounds for AKT1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Sumatriptan
  • Imigran
103628-46-2

(1) IUPHAR Ligand for AKT1 Gene

Ligand Type Action Affinity Pubmed IDs
GSK690693 Inhibitor Inhibition

(125) Novoseek inferred chemical compound relationships for AKT1 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylinositol 88.5 120
phosphoinositide 83.7 107
ly294002 83.6 58
wortmannin 83.4 70
threonine 78 99

(4) PharmGKB related drug/compound annotations for AKT1 Gene

Drug/compound Annotation
carboplatin CA
cisplatin CA
everolimus
risperidone CA
genes like me logo Genes that share compounds with AKT1: view

Transcripts for AKT1 Gene

mRNA/cDNA for AKT1 Gene

Unigene Clusters for AKT1 Gene

V-akt murine thymoma viral oncogene homolog 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^
SP1: - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:
SP7:
SP8: -
SP9:
SP10:

ExUns: 16 ^ 17a · 17b ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10:

Relevant External Links for AKT1 Gene

GeneLoc Exon Structure for
AKT1
ECgene alternative splicing isoforms for
AKT1

Expression for AKT1 Gene

mRNA expression in normal human tissues for AKT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKT1 Gene

SOURCE GeneReport for Unigene cluster for AKT1 Gene Hs.525622

mRNA Expression by UniProt/SwissProt for AKT1 Gene

P31749-AKT1_HUMAN
Tissue specificity: Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.
genes like me logo Genes that share expressions with AKT1: view

Orthologs for AKT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AKT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKT1 36
  • 92.55 (n)
  • 91.29 (a)
AKT1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AKT1 36
  • 90.83 (n)
  • 96.25 (a)
AKT1 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKT1 36
  • 91.25 (n)
  • 96.87 (a)
AKT1 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akt1 36
  • 90.9 (n)
  • 98.33 (a)
Akt1 16
Akt1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AKT1 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKT1 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akt1 36
  • 90.9 (n)
  • 98.12 (a)
chicken
(Gallus gallus)
Aves AKT1 36
  • 76.94 (n)
  • 96.04 (a)
AKT1 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKT1 37
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia akt1 36
  • 75.5 (n)
  • 93.11 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01115725.1 37
  • 91 (a)
ManyToMany
LOC100331515 36
  • 74.93 (n)
  • 82.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta Akt1 37
  • 49 (a)
OneToMany
Akt1 38
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea akt-1 36
  • 57.05 (n)
  • 60.47 (a)
akt-1 37
  • 51 (a)
ManyToMany
akt-2 37
  • 49 (a)
ManyToMany
F28C10.3 38
  • 35 (a)
akt-1 38
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCH9 37
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9149 37
  • 62 (a)
OneToMany
Species with no ortholog for AKT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AKT1 Gene

ENSEMBL:
Gene Tree for AKT1 (if available)
TreeFam:
Gene Tree for AKT1 (if available)

Paralogs for AKT1 Gene

genes like me logo Genes that share paralogs with AKT1: view

Variants for AKT1 Gene

Sequence variations from dbSNP and Humsavar for AKT1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1130214 -- 104,793,397(-) TTTTG(G/T)GCTTG intron-variant, utr-variant-5-prime
rs1130233 -- 104,773,557(-) CGGGA(A/G)CGTGT synonymous-codon, reference
rs2230506 -- 104,774,967(-) GCGTC(C/T)TGCAG reference, synonymous-codon
rs2230508 -- 104,773,473(-) AACGT(A/G)GTGTA synonymous-codon, reference
rs2494731 -- 104,771,343(+) AGGAT(C/G)AAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKT1 Gene

Variant ID Type Subtype PubMed ID
dgv2009n71 CNV Loss 21882294
nsv902389 CNV Loss 21882294
nsv470678 CNV Gain 18288195
nsv470677 CNV Loss 18288195
dgv2012n71 CNV Loss 21882294
nsv517038 CNV Loss 19592680
nsv820230 CNV Gain 19587683
dgv2015n71 CNV Loss 21882294
nsv456455 CNV Loss 19166990
nsv902407 CNV Gain 21882294
dgv2016n71 CNV Loss 21882294
dgv2017n71 CNV Loss 21882294
esv2749227 CNV Deletion 23290073

Relevant External Links for AKT1 Gene

HapMap Linkage Disequilibrium report
AKT1
Human Gene Mutation Database (HGMD)
AKT1

Disorders for AKT1 Gene

(6) OMIM Diseases for AKT1 Gene (164730)

UniProtKB/Swiss-Prot

AKT1_HUMAN
  • Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. {ECO:0000269 PubMed:17611497}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene represented in this entry may be involved in disease pathogenesis.
  • Note=Genetic variations in AKT1 may play a role in susceptibility to ovarian cancer.
  • Proteus syndrome (PROTEUSS) [MIM:176920]: A highly variable, severe disorder of asymmetric and disproportionate overgrowth of body parts, connective tissue nevi, epidermal nevi, dysregulated adipose tissue, and vascular malformations. Many features of Proteus syndrome overlap with other overgrowth syndromes. {ECO:0000269 PubMed:21793738}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Cowden syndrome 6 (CWS6) [MIM:615109]: A form of Cowden syndrome, a hamartomatous polyposis syndrome with age-related penetrance. Cowden syndrome is characterized by hamartomatous lesions affecting derivatives of ectodermal, mesodermal and endodermal layers, macrocephaly, facial trichilemmomas (benign tumors of the hair follicle infundibulum), acral keratoses, papillomatous papules, and elevated risk for development of several types of malignancy, particularly breast carcinoma in women and thyroid carcinoma in both men and women. Colon cancer and renal cell carcinoma have also been reported. Hamartomas can be found in virtually every organ, but most commonly in the skin, gastrointestinal tract, breast and thyroid. Note=The disease is caused by mutations affecting the gene represented in this entry.

(84) Novoseek inferred disease relationships for AKT1 Gene

Disease -log(P) Hits PubMed IDs
cancer 53.2 80
insulin resistance 47.2 15
wiskott-aldrich syndrome 47.1 7
tumors 45 111
glioblastoma 36.1 6

Relevant External Links for AKT1

Genetic Association Database (GAD)
AKT1
Human Genome Epidemiology (HuGE) Navigator
AKT1
Tumor Gene Database (TGDB):
AKT1
genes like me logo Genes that share disorders with AKT1: view

Publications for AKT1 Gene

  1. Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes. (PMID: 11508278) Matsubara A. … Permutt M.A. (Diabetologia 2001) 3 4 23 49
  2. CREB is a regulatory target for the protein kinase Akt/PKB. (PMID: 9829964) Du K. … Montminy M. (J. Biol. Chem. 1998) 3 4 23
  3. PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. (PMID: 14761976) Ahn J.-Y. … Ye K. (J. Biol. Chem. 2004) 3 4 23
  4. Association of AKT1 with schizophrenia confirmed in a Japanese population. (PMID: 15522255) Ikeda M. … Ozaki N. (Biol. Psychiatry 2004) 3 23 49
  5. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PMID: 15718470) Sarbassov D.D. … Sabatini D.M. (Science 2005) 3 4 23

Products for AKT1 Gene

  • Addgene plasmids for AKT1

Sources for AKT1 Gene

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