Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AKT1 Gene

protein-coding   GIFtS: 78
GCID: GC14M105235

V-Akt Murine Thymoma Viral Oncogene Homolog 1

  See AKT1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
V-Akt Murine Thymoma Viral Oncogene Homolog 11 2     AKT2
Protein Kinase B Alpha2 3     PKB-ALPHA2
Proto-Oncogene C-Akt2 3     PRKBA2
PKB2 3     RAC-ALPHA2
RAC2 3     Rac Protein Kinase Alpha2
RAC-PK-alpha2 3     RAC-Alpha Serine/Threonine-Protein Kinase2
PKB Alpha2 3     Protein Kinase B3
EC 2.7.11.13 8     EC 2.7.118
CWS62 5     

External Ids:    HGNC: 3911   Entrez Gene: 2072   Ensembl: ENSG000001422087   OMIM: 1647305   UniProtKB: P317493   

Export aliases for AKT1 gene to outside databases

Previous GC identifers: GC14M102614 GC14M099226 GC14M103207 GC14M104361 GC14M085432


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for AKT1 Gene:
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary
and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The
activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It
was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT
is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a
transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and
inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus
syndrome. Multiple alternatively spliced transcript variants have been found for this gene. (provided by RefSeq,
Jul 2011)

GeneCards Summary for AKT1 Gene:
AKT1 (v-akt murine thymoma viral oncogene homolog 1) is a protein-coding gene. Diseases associated with AKT1 include proteus syndrome, and cowden syndrome 6. GO annotations related to this gene include enzyme binding and identical protein binding. An important paralog of this gene is GRK7.

UniProtKB/Swiss-Prot: AKT1_HUMAN, P31749
Function: AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT
kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and
angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream
substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity
has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced
translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50'
negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the
attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory
14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of
glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in
inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by
which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis
signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative
stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2
at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1
and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead
family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In
particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on
equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and
positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The
phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of
pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby
potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide
phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition
of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho
GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell
proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling
the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron
positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase
(PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF),
epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic
effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and
disassembly. May be involved in the regulation of the placental development. Phosphorylates STK4/MST1 at
'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation
and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of
its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation.
Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear
translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD
stimulates its pro-apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the
interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53
Function: AKT1-specific substrates have been recently identified, including palladin (PALLD), which
phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important
role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release
from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more
specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to
ionizing radiation

summary for AKT1 Gene:
Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival,
insulin signaling, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway,
resulting in the recruitment of Akt to the plasma membrane via the PH (plexstrin homology domain) of Akt.
Akt is fully activated by phosphorylation at two key sites: Ser308 (phosphorylated by PDK1) and Thr478
(phosphorylated by mTOR and DNA-PK). Akt can then phosphorylated a wide range of substrates including
transcription factors (e.g. FOXO1), kinases (GSK-3, Raf-1, ASK, Chk1) and other proteins with important
signaling roles (e.g. Bad, MDM2). There are three isoforms of Akt; Akt 1, 2 and 3 (also known as PKBalpha,
beta and gamma).

Gene Wiki entry for AKT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AKT1 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AKT1 promoter sequence
   Search Chromatin IP Primers for AKT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.32   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.32-q32.33

AKT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKT1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M105235:  view genomic region     (about GC identifiers)

Start:
105,235,686 bp from pter      End:
105,262,088 bp from pter
Size:
26,403 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AKT1_HUMAN, P31749 (See protein sequence)
Recommended Name: RAC-alpha serine/threonine-protein kinase  
Size: 480 amino acids; 55686 Da
Subunit: Interacts (via the C-terminus) with CCDC88A (via its C-terminus). Interacts with GRB10; the interaction
leads to GRB10 phosphorylation thus promoting YWHAE-binding (By similarity). Interacts with AGAP2 (isoform
2/PIKE-A); the interaction occurs in the presence of guanine nucleotides. Interacts with AKTIP. Interacts (via PH
domain) with MTCP1, TCL1A AND TCL1B. Interacts with CDKN1B; the interaction phosphorylates CDKN1B promoting
14-3-3 binding and cell-cycle progression. Interacts with MAP3K5 and TRAF6. Interacts with BAD, PPP2R5B, STK3 and
STK4. Interacts (via PH domain) with SIRT1. Interacts with SRPK2 in a phosphorylation-dependent manner. Interacts
with RAF1. Interacts with TRIM13; the interaction ubiquitinates AKT1 leading to its proteasomal degradation.
Interacts with TNK2 and CLK2. Interacts (via the C-terminus) with THEM4 (via its C-terminus). Interacts with and
phosphorylated by PDPK1
Caution: In light of strong homologies in the primary amino acid sequence, the 3 AKT kinases were long surmised to
play redundant and overlapping roles. More recent studies has brought into question the redundancy within AKT
kinase isoforms and instead pointed to isoform specific functions in different cellular events and diseases. AKT1
is more specifically involved in cellular survival pathways, by inhibiting apoptotic processes; whereas AKT2 is
more specific for the insulin receptor signaling pathway. Moreover, while AKT1 and AKT2 are often implicated in
many aspects of cellular transformation, the 2 isoforms act in a complementary opposing manner. The role of AKT3
is less clear, though it appears to be predominantly expressed in brain
Selected PDB 3D structures from and Proteopedia for AKT1 (see all 21):
1H10 (3D)        1UNP (3D)        1UNQ (3D)        1UNR (3D)        2UVM (3D)        2UZR (3D)    
Secondary accessions: B2RAM5 Q9BWB6

Explore the universe of human proteins at neXtProt for AKT1: NX_P31749

Explore proteomics data for AKT1 at MOPED

Post-translational modifications: 

  • O-GlcNAcylation at Thr-305 and Thr-312 inhibits activating phosphorylation at Thr-308 via disrupting the
    interaction between AKT1 and PDPK1. O-GlcNAcylation at Ser-473 also probably interferes with phosphorylation at
    this site1
  • Phosphorylation on Thr-308, Ser-473 and Tyr-474 is required for full activity. Activated TNK2 phosphorylates it on
    Tyr-176 resulting in its binding to the anionic plasma membrane phospholipid PA. This phosphorylated form
    localizes to the cell membrane, where it is targeted by PDPK1 and PDPK2 for further phosphorylations on Thr-308
    and Ser-473 leading to its activation. Ser-473 phosphorylation by mTORC2 favors Thr-308 phosphorylation by PDPK1.
    Phosphorylated at Thr-308 and Ser-473 by IKBKE and TBK1. Ser-473 phosphorylation is enhanced by interaction with
    AGAP2 isoform 2 (PIKE-A). Ser-473 phosphorylation is enhanced in focal cortical dysplasias with Taylor-type
    balloon cells. Ser-473 phosphorylation is enhanced by signaling through activated FLT3. Dephosphorylated at
    Thr-308 and Ser-473 by PP2A phosphatase. The phosphorylated form of PPP2R5B is required for bridging AKT1 with
    PP2A phosphatase1
  • Ubiquitinated via 'Lys-48'-linked polyubiquitination by ZNRF1, leading to its degradation by the proteasome (By
    similarity). Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. TRAF6-induced
    'Lys-63'-linked AKT1 ubiquitination is critical for phosphorylation and activation. When ubiquitinated, it
    translocates to the plasma membrane, where it becomes phosphorylated. When fully phosphorylated and translocated
    into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the
    proteasome. Also ubiquitinated by TRIM13 leading to its proteasomal degradation. Phosphorylated, undergoes
    'Lys-48'-linked polyubiquitination preferentially at Lys-284 catalyzed by MUL1, leading to its proteasomal
    degradation1
  • Acetylated on Lys-14 and Lys-20 by the histone acetyltransferases EP300 and KAT2B. Acetylation results in reduced
    phosphorylation and inhibition of activity. Deacetylated at Lys-14 and Lys-20 by SIRT1. SIRT1-mediated
    deacetylation relieves the inhibition1
  • Ubiquitination2 at Lys8, Lys30, Lys39, Lys276
  • Glycosylation2 at Ser126, Ser129, Thr305, Thr312, Ser473
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for AKT1 (P31749) (see all 35)
     VVYRDLK  YYAMKIL  GVVMYEM  AEIVSAL 


    See AKT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001014431.1  NP_001014432.1  NP_005154.2  

    ENSEMBL proteins: 
     ENSP00000451828   ENSP00000384293   ENSP00000270202   ENSP00000385326   ENSP00000450688  
     ENSP00000451470   ENSP00000450681   ENSP00000443897   ENSP00000451166   ENSP00000451290  
     ENSP00000451824  
    Reactome Protein details: P31749

    AKT1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant AKT1 Protein
    R&D Systems Recombinant & Natural Proteins for AKT1
    Enzo Life Sciences proteins for AKT1
    OriGene Purified Proteins for AKT1
    OriGene Protein Over-expression Lysate for AKT1
    OriGene MassSpec for AKT1
    OriGene Custom Protein Services for AKT1
    GenScript Custom Purified and Recombinant Proteins Services for AKT1
    Novus Biologicals AKT1 Proteins
    Novus Biologicals AKT1 Lysates
    Sino Biological Recombinant Protein for AKT1
    Sino Biological Cell Lysate for AKT1
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for AKT1 

    AKT1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of AKT1
    R&D Systems Antibodies for AKT1
    Cell Signaling Technology (CST) Antibodies for AKT1 
    OriGene Antibodies for AKT1
    OriGene Custom Antibody Services for AKT1
    Novus Biologicals AKT1 Antibodies
    Abcam antibodies for AKT1 (P31751, P31749)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for AKT1
    LSBio Antibodies in human, mouse, rat for AKT1

    AKT1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of AKT1
    OriGene Custom Assay Services for AKT1
    R&D Systems ELISAs for AKT1         (see all)
    GenScript AKT1-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for AKT1
    Enzo Life Sciences assays for AKT1
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for AKT1: (see all 2
                        AKT Activation InstantOne ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: v-akt murine thymoma viral oncogene homolog 1
    Protein kinase B

    Selected InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry P31749

    ProtoNet protein and cluster: P31749

    2 Blocks protein domains:
    IPB000961 Protein kinase C-terminal domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: AKT1_HUMAN, P31749
    Domain: Binding of the PH domain to phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) following
    phosphatidylinositol 3-kinase alpha (PIK3CA) activity results in its targeting to the plasma membrane. The PH
    domain mediates interaction with TNK2 and Tyr-176 is also essential for this interaction
    Domain: The AGC-kinase C-terminal mediates interaction with THEM4
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with AKT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKT1_HUMAN, P31749
    Function: AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT
    kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and
    angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream
    substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity
    has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced
    translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50'
    negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the
    attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory
    14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of
    glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in
    inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by
    which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis
    signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative
    stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2
    at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1
    and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead
    family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In
    particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on
    equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and
    positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The
    phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of
    pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby
    potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide
    phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition
    of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho
    GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell
    proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling
    the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron
    positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase
    (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF),
    epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic
    effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and
    disassembly. May be involved in the regulation of the placental development. Phosphorylates STK4/MST1 at
    'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation
    and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of
    its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation.
    Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear
    translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD
    stimulates its pro-apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the
    interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53
    Function: AKT1-specific substrates have been recently identified, including palladin (PALLD), which
    phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important
    role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release
    from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more
    specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to
    ionizing radiation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Three specific sites, one in the kinase domain (Thr-308) and the two other ones in the
    C-terminal regulatory region (Ser-473 and Tyr-474), need to be phosphorylated for its full activation. Inhibited
    by pyrrolopyrimidine inhibitors like aniline triazole and spiroindoline
    Biophysicochemical properties: Kinetic parameters: KM=52.8 uM for ATP (for purified and in vitro activated AKT1);
    KM=0.5 uM for peptide substrate (for purified and in vitro activated AKT1); KM=143.3 uM for ATP (for recombinant
    myristoylated AKT1 expressed and immunoprecipitated from Rat-1 cells); KM=2.9 uM for peptide substrate (for
    recombinant myristoylated AKT1 expressed and immunoprecipitated from Rat-1 cells);

         Genatlas biochemistry entry for AKT1:
    V-akt murine thymoma viral oncogen homolog 1,general mediator of cell survival induced by insulin growth factor
    1,AKT1 and others activated by phosphadidylinositol 3-kinase in the antiapoptotic PIK3 pathway,phosphorylating
    and inactivating components of the apoptotic machinery including BAD,CASP9 and the transcription factor FKHRL1

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10570282
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005080protein kinase C binding IEA--
    GO:0005515protein binding IPI11154276
         
    Find genes that share ontologies with AKT1           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for AKT1:
     Decreased p24 protein expressi  Decreased viability after Chla  Decreased viability with TRAIL  Increases Tamoxifen sensitivit 
     Weaker migration  Wnt reporter downregulated 

         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Akt1) (see all 20):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  muscle  nervous system 

    Find genes that share phenotypes with AKT1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for AKT1: Akt1tm1Nhy Akt1tm1Mbb Akt1tm2.1Mbb

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AKT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AKT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AKT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AKT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target AKT1:
    hsa-mir-302b-3p (MIRT007172), hsa-mir-451a (MIRT005740), hsa-mir-143-3p (MIRT007179), hsa-mir-302c-3p (MIRT007173), hsa-mir-193b-3p (MIRT041236), hsa-mir-185-5p (MIRT004701), hsa-mir-149-3p (MIRT005355), hsa-mir-26b-5p (MIRT029530), hsa-mir-125b-5p (MIRT004363), hsa-mir-302a-3p (MIRT007171), hsa-mir-302d-3p (MIRT007174)

    Block miRNA regulation of human, mouse, rat AKT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AKT1 (see all 21):
    hsa-miR-520e hsa-miR-302d hsa-miR-374a hsa-miR-302e hsa-miR-520a-3p hsa-miR-633 hsa-miR-372 hsa-miR-520d-3p
    SwitchGear 3'UTR luciferase reporter plasmidAKT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AKT1
    Predesigned siRNA for gene silencing in human, mouse, rat AKT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AKT1

    Clone
    Products:
         
    OriGene clones in human, mouse for AKT1 (see all 18)
    OriGene ORF clones in mouse, rat for AKT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): AKT1 (NM_005163)
    Sino Biological Human cDNA Clone for AKT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKT1
    Addgene plasmids for AKT1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AKT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for AKT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKT1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12111) for AKT1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AKT1_HUMAN, P31749: Cytoplasm. Nucleus. Cell membrane. Note=Nucleus after activation by integrin-linked protein
    kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2
    results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and
    Ser-473 leading to its activation and the activated form translocates to the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    plasma membrane5
    cytoskeleton4
    extracellular3
    mitochondrion3
    endoplasmic reticulum2
    endosome2
    lysosome2
    peroxisome2
    vacuole2
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS--
    GO:0005819spindle IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with AKT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for AKT1 About   (see all 230)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF signaling pathway0.39
    Immune response BCR pathway0.43
    VEGF - VEGF R2 Signaling Pathways0.35
    Fc epsilon RI signaling pathway0.41
    Fc-epsilon receptor I signaling in mast cells0.34
    2Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Cell adhesion PLAU signaling0.35
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Transcription PPAR Pathway0.34
    Transcription Receptor mediated HIF regulation0.51
    Development Growth hormone signaling via PI3K AKT and MAPK cascades0.34
    Translation Regulation activity of EIF20.47
    mTOR signaling pathway0.34
    3IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-7 Signaling Pathways0.90
    IL-9 Signaling Pathway0.42
    IL-21 Signaling Pathways0.90
    IL-7 Signaling Pathway0.40
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    Development Thrombopoietin regulated cell processes0.38
    4Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    Immune response IL 4 signaling pathway0.39
    5B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    T cell receptor signaling pathway0.38
    BCR signaling pathway0.42
    TCR Signaling Pathway0.36


    Find genes that share SuperPaths with AKT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for AKT1 (see all 12)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AKT1 (see all 90)
        Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    ERK5 Signaling

    2 Cell Signaling Technology (CST) Pathways for AKT1
        PI3K / Akt Signaling
    Glucose / Energy Metabolism

    Selected Tocris Bioscience Pathways for AKT1 (see all 8)
        Akt Pathway
    Insulin Pathway
    Toll-like Receptor Pathway
    Apoptosis Pathway
    TGF-beta Pathway

    Selected GeneGo (Thomson Reuters) Pathways for AKT1 (see all 70)
        Development A2A receptor signaling
    Development CNTF receptor signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Signal transduction AKT signaling

    Selected BioSystems Pathways for AKT1 (see all 109)
        MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Angiogenesis
    Focal Adhesion
    Apoptosis

    Selected Sino Biological Pathways for AKT1 (see all 6)
        TNF Signaling
    EGFR Signaling Pathway
    p53 Pathway
    VEGF Signaling
    Death Receptor Signaling

    Selected Reactome Pathways for AKT1 (see all 19)
        deactivation of the beta-catenin transactivating complex
    AKT phosphorylates targets in the nucleus
    AKT-mediated inactivation of FOXO1A
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    Downregulation of ERBB2:ERBB3 signaling

    5 PharmGKB Pathways for AKT1
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
    Celecoxib Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for AKT1) (see all 55):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AKT1 (see all 37): 
              Lung Cancer in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat
              Mitochondria in human mouse rat
              Breast Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AKT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AKT1 (P317491, 2, 3 ENSP000002702024) via UniProtKB, MINT, STRING, and/or I2D (see all 397)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK4Q130431, 2, 3, ENSP000003618924EBI-296087,EBI-367376 MINT-6175011 MINT-6175193 MINT-6175251 MINT-6175225 MINT-6174722 MINT-6175034 MINT-6175070 MINT-6175132 MINT-6175047 MINT-6175025 MINT-6175115 MINT-6175085 MINT-6175239 I2D: score=2 STRING: ENSP00000361892
    SORBS2O948752, 3, ENSP000002847764MINT-61344 MINT-61469 MINT-61464 MINT-61466 MINT-61479 MINT-61468 MINT-61467 MINT-61463 MINT-61346 MINT-61345 MINT-61462 MINT-61465 I2D: score=2 STRING: ENSP00000284776
    PLCG1P191741, 2, 3, ENSP000002440074EBI-296087,EBI-79387 MINT-7146749 MINT-7146647 MINT-7146716 MINT-7146688 MINT-7146767 MINT-7146702 MINT-7146731 MINT-7146671 MINT-7146657 I2D: score=1 STRING: ENSP00000244007
    PPP1CAP621361, 2, 3, ENSP000003260314EBI-296087,EBI-357253 MINT-8291728 MINT-8291740 MINT-8291812 MINT-8291704 MINT-8291680 MINT-8291788 I2D: score=1 STRING: ENSP00000326031
    PPP2CAP677751, 2, 3, ENSP000004184474EBI-296087,EBI-712311 MINT-8203971 MINT-8288050 MINT-8288043 MINT-74931 MINT-74941 I2D: score=4 STRING: ENSP00000418447
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 109):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IMP16280327
    GO:0001649osteoblast differentiation IEA--
    GO:0001893maternal placenta development IEA--
    GO:0001934positive regulation of protein phosphorylation IDA19057511
    GO:0001938positive regulation of endothelial cell proliferation IMP19850054

    Find genes that share ontologies with AKT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for AKT1 (see all 12)     About this table
    CompoundAction CAS #
    A-674563potent selective protein kinase B/Akt inhibitor[552325-73-2]
    AT7867potent ATP-competitive inhibitor of Akt1, Akt2 and Akt3[857531-00-1]
    AZD5363Orally bioavailable, selective and potent inhibitor of all PKB/AKT iso-forms[1143532-39-1]
    BX795Cell-permeable, ATP-competitive and reversible PDK1 inhibitor[702675-74-9]
    CCT128930novel potent ATP-competitive AKT inhibitor[885499-61-6]
    GDC-0068 (RG7440)Akt inhibitor[1001264-89-6]
    GSK690693Potent, ATP-competitive pan-Akt inhibitor[937174-76-0]
    MK-2206 dihydrochloridea highly selective non-ATP competitive allosteric Akt inhibitor[1032350-13-2]
    Palomid 529novel potent antitumour PI3K/Akt/mTOR inhibitor[914913-88-5]
    PerifosineAKT inhibitor[157716-52-4]

    Compounds for AKT1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    10-DEBC hydrochlorideSelective Akt/PKB inhibitor[201788-90-1]
    API-2Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral[35943-35-2]
    FPA 124Akt/PKB inhibitor[902779-59-3]
    API-1Selective Akt/PKB inhibitor. Antitumor[36707-00-3]
    SC 79Akt activator[305834-79-1]

    3 HMDB Compounds for AKT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    SumatriptanImigran (see all 4)103628-46-2--

    5 DrugBank Compounds for AKT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Arsenic trioxideAcide Arsenieux [French] (see all 11)1327-53-3targetinducer16239170 12472888 15580309 12529330 15916724
    Inositol 1,3,4,5-Tetrakisphosphate-- --target--17139284 17016423
    5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-- --target--10592235
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17041888
    N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine-- --target--10592235

    1 IUPHAR Ligand for AKT1 (v-akt murine thymoma viral oncogene homolog 1)    About this table
    LigandTypeActionAffinityPubmed IDs
    GSK690693
    InhibitorInhibition18800763

    Selected Novoseek inferred chemical compound relationships for AKT1 gene (see all 125)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 88.5 246 12551955 (5), 10578066 (5), 8645157 (3), 10671514 (3) (see all 99)
    phosphoinositide 83.7 125 10454216 (4), 10102683 (3), 9671484 (2), 15292195 (2) (see all 88)
    ly294002 83.6 78 15752900 (3), 15347471 (3), 16842970 (3), 10623881 (2) (see all 48)
    wortmannin 83.4 88 17380453 (3), 16458614 (2), 9346964 (2), 9755080 (2) (see all 62)
    threonine 78 116 10362672 (1), 10411946 (1), 10491192 (1), 11279265 (1) (see all 99)
    phosphatidylinositol-3,4,5-trisphosphate 77.6 20 7738099 (1), 15107457 (1), 9228007 (1), 12421919 (1) (see all 18)
    serine 71.1 120 16780593 (3), 16141217 (2), 10362672 (1), 10411946 (1) (see all 99)
    rapamycin 70 48 10623881 (2), 17565979 (2), 10567225 (2), 17616691 (2) (see all 35)
    glycogen 69.9 112 11574400 (5), 10623881 (4), 9478990 (3), 10446195 (2) (see all 68)
    tyrosine 69.3 113 9593727 (3), 7616102 (3), 9415029 (3), 10623881 (2) (see all 79)

    4 PharmGKB related drug/compound annotations for AKT1 gene    About this table
    Drug/compound PharmGKB Annotation
    carboplatinCA  
    cisplatinCA  
    everolimus
    risperidoneCA  



    Find genes that share compounds with AKT1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AKT1 gene (3 alternative transcripts): 
    NM_001014431.1  NM_001014432.1  NM_005163.2  

    Unigene Cluster for AKT1:

    V-akt murine thymoma viral oncogene homolog 1
    Hs.525622  [show with all ESTs]
    Unigene Representative Sequence: AK122894
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554581(uc001ypk.3 uc001ypl.3) ENST00000407796 ENST00000349310(uc001ypm.3 uc001ypn.3)
    ENST00000553506 ENST00000557552(uc001ypj.3 uc010tyk.2) ENST00000402615(uc010axa.3)
    ENST00000555528 ENST00000555458 ENST00000554192 ENST00000544168 ENST00000554585
    ENST00000554848 ENST00000554826 ENST00000556836 ENST00000555380 ENST00000555926
    ENST00000557494 ENST00000553797
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AKT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AKT1 (see all 21):
    hsa-miR-520e hsa-miR-302d hsa-miR-374a hsa-miR-302e hsa-miR-520a-3p hsa-miR-633 hsa-miR-372 hsa-miR-520d-3p
    SwitchGear 3'UTR luciferase reporter plasmidAKT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AKT1
    Predesigned siRNA for gene silencing in human, mouse, rat AKT1
    Clone
    Products:
         
    OriGene clones in human, mouse for AKT1 (see all 18)
    OriGene ORF clones in mouse, rat for AKT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): AKT1 (NM_005163)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKT1
    Addgene plasmids for AKT1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AKT1
    OriGene qSTAR qPCR primer pairs in human, mouse for AKT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AKT1
      QuantiTect SYBR Green Assays in human, mouse, rat AKT1
      QuantiFast Probe-based Assays in human, mouse, rat AKT1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12111) for AKT1 

    Additional mRNA sequence: 

    AB451242.1 AB451367.1 AK122894.1 AK299310.1 AK314256.1 BC000479.2 BC001737.1 BC063408.1 
    BC084538.1 BX648205.1 M63167.1 X61037.1 

    24 DOTS entries:

    DT.450038  DT.100059722  DT.100824191  DT.100059719  DT.95090241  DT.100733482  DT.120765970  DT.92461206 
    DT.100824190  DT.100824203  DT.102829546  DT.100824201  DT.75100119  DT.95341680  DT.100059721  DT.120765944 
    DT.95090231  DT.95090239  DT.95090245  DT.120765955  DT.120765973  DT.92461194  DT.92461227  DT.95124889 

    13 AceView cDNA sequences:

    BC001737 AK131465 BC000479 BX648205 CR611982 AK122894 AK094287 BX647722 
    AK127193 M63167 NM_005163 X61037 BC063408 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AKT1 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^
    SP1:                                                                                      -     -                                                               
    SP2:                                                                                      -     -                                                           -   
    SP3:                                                                                      -     -                                                               
    SP4:                                                                                -     -     -                                                               
    SP5:                                                                                                                                -                       -   

    ExUns: 16 ^ 17a · 17b ^ 18
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for AKT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AKT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AKT1 Expression
    About this image


    AKT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Endothelium (Cardiovascular System)
             Angioblasts Embryonic Blood Islands
    AKT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525622

    UniProtKB/Swiss-Prot: AKT1_HUMAN, P31749
    Tissue specificity: Expressed in prostate cancer and levels increase from the normal to the malignant state (at
    protein level). Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a
    significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia
    (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AKT1 (see all 37): 
              Lung Cancer in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat
              Mitochondria in human mouse rat
              Breast Cancer in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AKT1
    OriGene qSTAR qPCR primer pairs in human, mouse for AKT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AKT1
    QuantiTect SYBR Green Assays in human, mouse, rat AKT1
    QuantiFast Probe-based Assays in human, mouse, rat AKT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AKT1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akt11 , 5 thymoma viral proto-oncogene 11, 5 90.9(n)1
    98.33(a)1
      12 (61.20 cM)5
    116511  NM_009652.31  NP_033782.11 
     1126538215 
    chicken
    (Gallus gallus)
    Aves AKT11 v-akt murine thymoma viral oncogene homolog 1 76.94(n)
    96.04(a)
      395928  NM_205055.1  NP_990386.1 
    lizard
    (Anolis carolinensis)
    Reptilia AKT16
    v-akt murine thymoma viral oncogene homolog 1
    96(a)
    1 ↔ 1
    1(3696188-3809503)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF317656.12   -- 76.92(n)    AF317656.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003315151 RAC-alpha serine/threonine-protein kinase-like 74.93(n)
    82.84(a)
      100331515  XM_003200288.2  XP_003200336.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Akt13 anti-apoptosis protein serine/threonine
    kinase
    61(a)   89B6   --
    worm
    (Caenorhabditis elegans)
    Secernentea akt-11 , 3 PH (pleckstrin homology) domain,
    Protein kinase more3
    akt-11
    55(a)
    (best of 2)3
    57.05(n)1
    60.47(a)1
      V(10251544-10255039)3
    1794241  NM_001028475.21  NP_001023646.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SCH96
    Protein kinase involved in transcriptional activat...
    24(a)
    1 → many
    VIII(509363-511837) YHR205W


    ENSEMBL Gene Tree for AKT1 (if available)
    TreeFam Gene Tree for AKT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for AKT1 gene
    GRK72  RPS6KB12  GRK12  SGK32  GRK42  GRK62  C8orf44-SGK32  SGK22  
    ADRBK22  AKT32  SGK12  RPS6KB22  GRK52  ADRBK12  AKT22  
    Selected SIMAP similar genes for AKT1 using alignment to 7 protein entries:     AKT1_HUMAN (see all proteins) (see all similar genes):
    AKT2    AKT3    KIN27    PRKCH    PRKCZ    SGK2
    PRKACB    PRKCA    PKN2    PRKCE    PKN1    PRKACA
    PRKCI    RPS6KA2    DKFZp781N0293    SGK3    SGKL    MARK4

    Find genes that share paralogs with AKT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for AKT1 (see all 514)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1214345921,2,,4
    CProteus syndrome (PROTEUSS)4 pathogenic1105246551(-) TAGGGA/GAGTAC 6 K E mis10--------
    rs617612541,2
    C,F--105235233(-) GCCAAG/CGTCAT 3 -- ds50013Minor allele frequency- C:0.15NS WA 210
    rs1467312121,2
    --105235369(+) CTGGGG/TTGAAG 3 -- ds50010--------
    rs24988011,2
    C,F,A--105235558(-) CCCCAA/GCAGGT 3 -- ds50018Minor allele frequency- G:0.46NA NS CSA WA EA 451
    rs617612531,2
    C,F--105235640(-) GGAGGG/CAGTGG 3 -- ds50013Minor allele frequency- C:0.01NS WA 212
    rs1906051781,2
    --105235787(+) GTGGTA/GCAGCG 3 -- ut310--------
    rs1403207431,2
    --105235791(+) TGCAGC/TGGCAG 3 -- ut310--------
    rs1833602001,2
    --105235804(+) GCAGCA/GTCTGG 3 -- ut310--------
    rs178468291,2
    C,F--105235818(-) TCCACG/ACCTCC 3 -- ut31 ese35Minor allele frequency- A:0.13NS NA WA 254
    rs585652161,2
    C,F--105235824(+) GTGGAG/CGGGCC 3 -- ut314Minor allele frequency- C:0.25NS WA 208

    HapMap Linkage Disequilibrium report for AKT1 (105235686 - 105262088 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AKT1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749227CNV Deletion23290073
    dgv2017n71CNV Loss21882294
    dgv2016n71CNV Loss21882294
    dgv2015n71CNV Loss21882294
    nsv517038CNV Loss19592680
    dgv2009n71CNV Loss21882294
    dgv2012n71CNV Loss21882294
    nsv470677CNV Loss18288195
    nsv456455CNV Loss19166990
    nsv902389CNV Loss21882294

    Human Gene Mutation Database (HGMD): AKT1
    4 Site Specific Mutation Identification with PCR Assays for AKT1:
    Cosmic IdAA Change
    33765p.E17K
    36918p.E49K
    33765p.E17K
    48226p.F35L
    Selected Site Specific Cancer Mutation PCR Panels containing AKT1 (see all 19):
    Breast Cancer
    Receptor Tyrosine Kinase (RTK) (Panel II)
    Cancer Comprehensive Panel 384HT
    Lung Cancer
    KIT Pathway
    4 Copy Number PCR Panels containing AKT1:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    Lung Cancer
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing AKT1
    DNA2.0 Custom Variant and Variant Library Synthesis for AKT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 164730   
    OMIM disorders: 114480  114500  167000  181500  176920  615109  
    UniProtKB/Swiss-Prot: AKT1_HUMAN, P31749
  • Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast
    neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common
    type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated
    by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different
    families or even in the same case. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from
    the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with
    progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon
    and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene
    represented in this entry may be involved in disease pathogenesis
  • Note=Genetic variations in AKT1 may play a role in susceptibility to ovarian cancer
  • Proteus syndrome (PROTEUSS) [MIM:176920]: A highly variable, severe disorder of asymmetric and
    disproportionate overgrowth of body parts, connective tissue nevi, epidermal nevi, dysregulated adipose tissue,
    and vascular malformations. Many features of Proteus syndrome overlap with other overgrowth syndromes. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Cowden syndrome 6 (CWS6) [MIM:615109]: A form of Cowden syndrome, a hamartomatous polyposis syndrome with
    age-related penetrance. Cowden syndrome is characterized by hamartomatous lesions affecting derivatives of
    ectodermal, mesodermal and endodermal layers, macrocephaly, facial trichilemmomas (benign tumors of the hair
    follicle infundibulum), acral keratoses, papillomatous papules, and elevated risk for development of several
    types of malignancy, particularly breast carcinoma in women and thyroid carcinoma in both men and women. Colon
    cancer and renal cell carcinoma have also been reported. Hamartomas can be found in virtually every organ, but
    most commonly in the skin, gastrointestinal tract, breast and thyroid. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for AKT1 (see all 28):    
    About MalaCards
    proteus syndrome    cowden syndrome 6    proteus syndrome, somatic    breast cancer, protection against
    breast cancer, lobular    anal squamous cell carcinoma    breast cancer, invasive ductal    breast cancer, early-onset
    cowden syndrome 1    polycystic kidney disease, autosomal dominant    breast cancer, somatic    thymoma
    serous cystadenocarcinoma    overnutrition    male breast cancer    ovarian cancer, somatic
    ovarian serous cystadenocarcinoma    breast cancer susceptibility    mitral valve disease    nonepidermolytic palmoplantar keratoderma

    Selected diseases from the University of Copenhagen DISEASES database for AKT1 (see all 29):
    Vascular disease     Breast cancer     Diabetes mellitus     Prostate cancer
    Malignant glioma     Lung cancer     Leukemia     Carcinoma
    Heart disease     Hyperglycemia     Hepatocellular carcinoma     Colorectal cancer
    Ovarian cancer     Melanoma     Pancreatic cancer     Lymphoma
    Brain disease     Neuroblastoma     Retinoblastoma     Thymoma

    Find genes that share disorders with AKT1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for AKT1 gene (see all 84)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 53.2 97 11571628 (5), 19216065 (3), 19876913 (3), 17611497 (3) (see all 66)
    insulin resistance 47.2 15 15634339 (2), 10373517 (1), 20101593 (1), 11274905 (1) (see all 14)
    wiskott-aldrich syndrome 47.1 7 15657136 (1), 10488099 (1), 18198193 (1), 11580754 (1) (see all 7)
    tumors 45 142 17027002 (4), 12191616 (4), 11593437 (4), 17639041 (4) (see all 80)
    glioblastoma 36.1 7 10958682 (2), 11439092 (1), 18250332 (1), 19234490 (1) (see all 5)
    breast cancer 34.4 50 16782806 (5), 16711509 (3), 18087195 (3), 16428439 (3) (see all 30)
    thymoma 29.8 12 16251502 (1), 15522255 (1), 17464696 (1), 17611497 (1) (see all 10)
    metastasis 27.4 17 19305425 (2), 15886842 (2), 19487299 (1), 20360004 (1) (see all 13)
    insulin sensitivity 27.2 2 18599621 (1), 18573875 (1)
    hyperinsulinemia 22.8 1 17513702 (1)

    Genetic Association Database (GAD): AKT1
    Human Genome Epidemiology (HuGE) Navigator: AKT1 (87 documents)
    Tumor Gene Database (TGDB): AKT1

    Export disorders for AKT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AKT1 gene, integrated from 10 sources (see all 3154) (see top 10):
    (articles sorted by number of sources associating them with AKT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes. (PubMed id 11508278)1, 2, 4, 9 Matsubara A....Permutt M.A. (Diabetologia 2001)
    2. Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib. (PubMed id 20159991)1, 4, 9 Giovannetti E....Tibaldi C. (Mol. Cancer Ther. 2010)
    3. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. (PubMed id 19164214)1, 4, 9 Hildebrandt M.A....Wu X. (J. Clin. Oncol. 2009)
    4. Association of AKT1 gene polymorphisms with risk of schizophrenia and with response to antipsychotics in the Chinese population. (PubMed id 17915974)1, 4, 9 Xu M.Q....He L. (J Clin Psychiatry 2007)
    5. Association of AKT1 with schizophrenia confirmed in a Japanese population. (PubMed id 15522255)1, 4, 9 Ikeda M....Ozaki N. (Biol. Psychiatry 2004)
    6. Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1. (PubMed id 19487299)1, 4, 9 Ricarte-Filho J.C....Fagin J.A. (Cancer Res. 2009)
    7. The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration. (PubMed id 20471940)1, 2, 9 Chin Y.R. and Toker A. (Mol. Cell 2010)
    8. AKT1 Gene Polymorphisms and Obstetric Complications in the Patients with Schizophrenia. (PubMed id 20046382)1, 4, 9 Joo E.J....Kim Y.S. (Psychiatry Investig 2009)
    9. Association of AKT1 haplotype with the risk of schizophrenia in Iranian population. (PubMed id 16583435)1, 4, 9 Bajestan S.N....Osame M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006)
    10. AKT1 polymorphisms are associated with tuberculosis in the Chinese population. (PubMed id 20141546)1, 4, 9 Wang X....Cheng X. (Int. J. Immunogenet. 2010)
    11. Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients. (PubMed id 19747927)1, 4, 9 Kishi T....Iwata N. (Neuropharmacology 2010)
    12. AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma. (PubMed id 19853286)1, 4, 9 Cohen Y....Rechavi G. (Gynecol. Oncol. 2010)
    13. Lack of association between AKT1 variances versus clinical manifestations and social function in patients with schizophrenia. (PubMed id 18635704)1, 4, 9 Liu Y.C....Lane H.Y. (J. Psychopharmacol. (Oxford) 2009)
    14. PI3K/Akt pathway mutations in retinoblastoma. (PubMed id 19420344)1, 4, 9 Cohen Y....Goldenberg-Cohen N. (amp 2009)
    15. Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting. (PubMed id 18611285)1, 4, 9 Do H....Dobrovic A. (BMC Res Notes 2008)
    16. Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample. (PubMed id 18466879)1, 4, 9 Soronen P....Paunio T. (Biol. Psychiatry 2008)
    17. Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia. (PubMed id 18855532)1, 4, 9 Ikeda M....Iwata N. (Pharmacogenomics 2008)
    18. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. (PubMed id 17611497)1, 2, 9 Carpten J.D.... Thomas J.E. (Nature 2007)
    19. The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. (PubMed id 17932490)1, 2, 9 Cinar B.... Freeman M.R. (EMBO J. 2007)
    20. Kinetic mechanism of AKT/PKB enzyme family. (PubMed id 16540465)1, 2, 9 Zhang X....Kendall R.L. (J. Biol. Chem. 2006)
    21. Cotreatment with a novel phosphoinositide analogue inhibitor and carmustine enhances chemotherapeutic efficacy by attenuating AKT activity in gliomas. (PubMed id 17041888)1, 7, 9 Van Meter T.E....Fillmore H. (Cancer 2006)
    22. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PubMed id 15718470)1, 2, 9 Sarbassov D.D.... Sabatini D.M. (Science 2005)
    23. PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. (PubMed id 14761976)1, 2, 9 Ahn J.-Y.... Ye K. (J. Biol. Chem. 2004)
    24. High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)- trisphosphate. (PubMed id 12176338)1, 2, 9 Thomas C.C.... van Aalten D.M. (Curr. Biol. 2002)
    25. CREB is a regulatory target for the protein kinase Akt/PKB. (PubMed id 9829964)1, 2, 9 Du K. and Montminy M. (J. Biol. Chem. 1998)
    26. Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes. (PubMed id 23246288)1, 2 Orloff M.S....Eng C. (Am. J. Hum. Genet. 2013)
    27. Akt is negatively regulated by the MULAN E3 ligase. (PubMed id 22410793)1, 2 Bae S....An S. (Cell Res. 2012)
    28. IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. (PubMed id 21464307)1, 2 Xie X....Guan K.L. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    29. A mosaic activating mutation in AKT1 associated with the Proteus syndrome. (PubMed id 21793738)1, 2 Lindhurst M.J.... Biesecker L.G. (N. Engl. J. Med. 2011)
    30. The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy. (PubMed id 21775285)1, 2 Sundaresan N.R.... Gupta M.P. (Sci. Signal. 2011)
    31. Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer. (PubMed id 21035469)1, 4 Slattery M.L....Wolff R.K. (Mutat. Res. 2011)
    32. Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2. (PubMed id 21333377)1, 2 Joo H.M.... Jin Y.W. (Eur. J. Cell Biol. 2011)
    33. Akt1 and Akt2: differentiating the aktion. (PubMed id 21432781)1, 2 Heron-Milhavet L.... Lamb N.J. (Histol. Histopathol. 2011)
    34. Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up. (PubMed id 21041608)1, 4 van Winkel R. (Arch. Gen. Psychiatry 2011)
    35. Endometrial cancer and genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2 within a population-based case-control study. (PubMed id 21093899)1, 4 Lacey J.V....Garcia-Closas M. (Gynecol. Oncol. 2011)
    36. PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-based chemotherapy. (PubMed id 20447721)1, 4 Pu X....Wu X. (Lung Cancer 2011)
    37. AKT1 polymorphisms are associated with risk for metabolic syndrome. (PubMed id 21061022)1, 4 Devaney J.M....Hoffman E.P. (Hum. Genet. 2011)
    38. Mutational and immunohistochemical study of the PI3K/Akt pathway in papillary thyroid carcinoma in Greece. (PubMed id 20186503)1, 4 Sozopoulos E....Tseleni-Balafouta S. (Endocr. Pathol. 2010)
    39. Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns. (PubMed id 20526288)1, 4 Rivera M....Ghossein R.A. (Mod. Pathol. 2010)
    40. Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population. (PubMed id 20033742)1, 4 Zhang K....Shen Y. (J Neural Transm 2010)
    41. Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120. (PubMed id 19940129)1, 2 Yuan Z.... Cheng J.Q. (J. Biol. Chem. 2010)
    42. Genetic association of the AKT1 gene with schizophrenia in a British population. (PubMed id 20421846)1, 4 Mathur A....Wei J. (Psychiatr. Genet. 2010)
    43. Preliminary evidence of ethnic divergence in associations of putative genetic variants for methamphetamine dependence. (PubMed id 20478633)1, 4 Bousman C.A....Everall I.P. (Psychiatry Res 2010)
    44. Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients. (PubMed id 20132317)1, 4 Magno L.A....Romano-Silva M.A. (Genes Brain Behav. 2010)
    45. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    46. Absence of activating somatic mutations of PI3KCA and AKT1 genes in South Indian women with endometriosis. (PubMed id 20493625)1, 4 Rai P....Shivaji S. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2010)
    47. No association between AKT1 polymorphism and schizophrenia: a case-control study in a Korean population and a meta-analysis. (PubMed id 19931325)1, 4 Lee K.Y....Kim Y.S. (Neurosci. Res. 2010)
    48. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    49. Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. (PubMed id 20333297)1, 2 Mahajan K.... Mahajan N.P. (PLoS ONE 2010)
    50. Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation. (PubMed id 20682768)1, 2 Nam S.Y.... Jin Y.W. (J. Biol. Chem. 2010)
    51. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    52. Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt. (PubMed id 20086174)1, 2 Romano D.... Kolch W. (Cancer Res. 2010)
    53. E17K substitution in AKT1 in prostate cancer. (PubMed id 20407443)1, 4 Boormans J.L....Trapman J. (Br. J. Cancer 2010)
    54. Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition. (PubMed id 20886116)1, 2 Wu W.I....Brandhuber B.J. (PLoS ONE 2010)
    55. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    56. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    57. Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. (PubMed id 20921115)1, 4 Nicodemus K.K....Weinberger D.R. (Arch. Gen. Psychiatry 2010)
    58. Single-nucleotide polymorphisms in the p53 pathway genes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent. (PubMed id 20306497)1, 4 Yarden R.I....Papa M.Z. (Mol. Carcinog. 2010)
    59. Molecular, morphologic, and outcome analysis of thyroid carcinomas according to degree of extrathyroid extension. (PubMed id 20860430)1, 4 Rivera M....Ghossein R. (Thyroid 2010)
    60. Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway. (PubMed id 20231902)1, 2 Kim D.... Cheng J.Q. (PLoS ONE 2010)
    61. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    62. A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells. (PubMed id 20978158)1, 2 Kunoh T.... Mizukami T. (Mol. Cancer Ther. 2010)
    63. Chronic myeloid leukemia and BCR/ABL signal pathways are not associated with AKT1 pleckstrin homology domain (E17K) mutations. (PubMed id 19744127)1, 4 He Y....Huang S. (Eur. J. Haematol. 2010)
    64. Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. (PubMed id 20622004)1, 4 Slattery M.L....Wolff R.K. (Carcinogenesis 2010)
    65. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (Gastroenterology 2010)
    66. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    67. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)1, 4 GregA^rio S.P....Dias-Neto E. (Psychiatry Res 2009)
    68. High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. (PubMed id 19458356)1, 4 Gutierrez A....Look A.T. (Blood 2009)
    69. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    70. The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. (PubMed id 20059950)1, 2 Suizu F.... Noguchi M. (Dev. Cell 2009)
    71. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    72. Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins. (PubMed id 19051289)1, 4 PietilAoinen O.P....Peltonen L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    73. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    74. Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. (PubMed id 19592491)1, 2 Jang S.W.... Ye K. (J. Biol. Chem. 2009)
    75. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)
    76. Genetic association studies of methamphetamine use disorders: A systematic review and synthesis. (PubMed id 19219857)1, 4 Bousman C.A....Tsuang M.T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    77. Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T&gt;C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin. (PubMed id 19219602)1, 4 Kim J.G....Jun S.H. (Cancer Chemother. Pharmacol. 2009)
    78. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    79. FGFR2 is associated with hair thickness in Asian populations. (PubMed id 19590514)1, 4 Fujimoto A....Ohashi J. (J. Hum. Genet. 2009)
    80. The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration. (PubMed id 19934221)1, 2 Bristow J.M....Webb D.J. (J. Cell Sci. 2009)
    81. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. (PubMed id 19713527)1, 2 Yang W.-L.... Lin H.-K. (Science 2009)
    82. No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. (PubMed id 18198266)1, 4 Sanders A.R....Gejman P.V. (Am J Psychiatry 2008)
    83. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. (PubMed id 18583979)1, 4 Allen N.C....Bertram L. (Nat. Genet. 2008)
    84. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    85. Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain. (PubMed id 18954143)1, 2 Landgraf K.E.... Falke J.J. (Biochemistry 2008)
    86. Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans. (PubMed id 18497887)1, 4 Tan H.Y....Weinberger D.R. (J. Clin. Invest. 2008)
    87. Genetic study of eight AKT1 gene polymorphisms and their interaction with DRD2 gene polymorphisms in tardive dyskinesia. (PubMed id 18838251)1, 4 Zai C.C....Kennedy J.L. (Schizophr. Res. 2008)
    88. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    89. Association between AKT1 gene and Parkinson's disease: a protective haplotype. (PubMed id 18395980)1, 4 Xiromerisiou G....Singleton A.B. (Neurosci. Lett. 2008)
    90. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    91. Association analysis of AKT1 and schizophrenia in a UK case control sample. (PubMed id 17383860)1, 4 Norton N....O'Donovan M.C. (Schizophr. Res. 2007)
    92. The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland. (PubMed id 17300918)1, 4 Turunen J.A....Peltonen L. (Schizophr. Res. 2007)
    93. Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation. (PubMed id 17726016)1, 2 Jang S.W.... Ye K. (J. Biol. Chem. 2007)
    94. Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia. (PubMed id 17233643)1, 4 Ikeda M....Iwata N. (Genes Brain Behav. 2007)
    95. Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha. (PubMed id 16417524)1, 2 Srinivas H.... Kurie J.M. (Biochem. J. 2006)
    96. Absence of significant associations between four AKT1 SNP markers and schizophrenia in the Taiwanese population. (PubMed id 16395129)1, 4 Liu Y.L....Hwu H.G. (Psychiatr. Genet. 2006)
    97. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    98. Positive association of AKT1 haplotype to Japanese methamphetamine use disorder. (PubMed id 15982448)1, 4 Ikeda M....Ozaki N. (Int. J. Neuropsychopharmacol. 2006)
    99. Akt/PKB regulates actin organization and cell motility via Girdin/APE. (PubMed id 16139227)1, 2 Enomoto A.... Takahashi M. (Dev. Cell 2005)
    100. Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. (PubMed id 14749367)1, 2 Remy I. and Michnick S.W. (Mol. Cell. Biol. 2004)
    101. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    102. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    103. PIKE-A is amplified in human cancers and prevents apoptosis by up- regulating Akt. (PubMed id 15118108)1, 2 Ahn J.-Y.... Ye K. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    104. PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. (PubMed id 12244301)1, 2 Shin I....Arteaga C.L. (Nat. Med. 2002)
    105. A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. (PubMed id 11994271)1, 2 Kane S....Lienhard G.E. (J. Biol. Chem. 2002)
    106. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)1, 2 Fujita N.... Tsuruo T. (J. Biol. Chem. 2002)
    107. Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase. (PubMed id 12149249)1, 2 Conus N.M.... Pearson R.B. (J. Biol. Chem. 2002)
    108. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. (PubMed id 12150915)1, 2 Manning B.D.... Cantley L.C. (Mol. Cell 2002)
    109. Akt phosphorylates and negatively regulates apoptosis signal- regulating kinase 1. (PubMed id 11154276)1, 2 Kim A.H.... Chao M.V. (Mol. Cell. Biol. 2001)
    110. Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. (PubMed id 11598301)1, 2 Maira S.-M....Hemmings B.A. (Science 2001)
    111. Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage. (PubMed id 10926925)1, 2 Koh H.... Chung J. (J. Biol. Chem. 2000)
    112. The protooncogene TCL1 is an Akt kinase coactivator. (PubMed id 10983986)1, 2 Laine J.... Noguchi M. (Mol. Cell 2000)
    113. Phosphorylation and regulation of Raf by Akt (protein kinase B). (PubMed id 10576742)1, 2 Zimmermann S. and Moelling K. (Science 1999)
    114. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. (PubMed id 9736715)1, 2 Delcommenne M.... Dedhar S. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    115. Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. (PubMed id 9512493)1, 2 Walker K.S.... Alessi D.R. (Biochem. J. 1998)
    116. Mechanism of activation of protein kinase B by insulin and IGF-1. (PubMed id 8978681)1, 2 Alessi D.R.... Hemmings B.A. (EMBO J. 1996)
    117. Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. (PubMed id 1533586)1, 2 Coffer P.J. and Woodgett J.R. (Eur. J. Biochem. 1992)
    118. Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. (PubMed id 1851997)1, 2 Jones P.F.... Hemmings B.A. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    119. Molecular cloning and characterisation of a novel putative protein- serine kinase related to the cAMP-dependent and protein kinase C families. (PubMed id 1718748)1, 2 Coffer P.J. and Woodgett J.R. (Eur. J. Biochem. 1991)
    120. Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway. (PubMed id 16174774)1, 9 Park S....Cheng J.Q. (J. Biol. Chem. 2005)
    121. Rapid activation of Rac GTPase in living cells by force is independent of Src. (PubMed id 19924282)1, 9 Poh Y.C....Wang N. (PLoS ONE 2009)
    122. Protein kinase Czeta is a negative regulator of protein kinase B activity. (PubMed id 10085094)1, 9 Doornbos R.P....van Bergen en Henegouwen P.M. (J. Biol. Chem. 1999)
    123. Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models. (PubMed id 20520724)1, 9 Sei Y....Weinberger D.R. (PLoS ONE 2010)
    124. AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families. (PubMed id 17825267)1, 9 Thiselton D.L....Riley B.P. (Biol. Psychiatry 2008)
    125. Differential activation of CREB by Akt1 and Akt2. (PubMed id 17276404)1, 9 Kato S....Du K. (Biochem. Biophys. Res. Commun. 2007)
    126. Regulation of protein kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines. (PubMed id 16842970)1, 9 Sharrard R.M. and Maitland N.J. (Cell. Signal. 2007)
    127. Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. (PubMed id 10716693)2, 9 Pekarsky Y.... Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    128. Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation. (PubMed id 20133737)1, 9 Ericson K....Papadopoulos N. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    129. PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity. (PubMed id 18249092)1, 9 Ma K....Duronio V. (Cell. Signal. 2008)
    130. The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation. (PubMed id 17914025)1, 9 Yin H....Du X. (Blood 2008)
    131. AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway. (PubMed id 17616691)1, 9 Liu L.Z....Jiang B.H. (Cancer Res. 2007)
    132. Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells. (PubMed id 15888491)1, 9 Dihlmann S....von Knebel Doeberitz M. (Carcinogenesis 2005)
    133. WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate. (PubMed id 14611643)1, 9 Vitari A.C....Alessi D.R. (Biochem. J. 2004)
    134. Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1). (PubMed id 20360004)1, 9 Rajagopal S....Buchsbaum R.J. (J. Biol. Chem. 2010)
    135. The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas. (PubMed id 19491896)1, 9 Shoji K....Taketani Y. (Br. J. Cancer 2009)
    136. Complex formation of p65/RelA with nuclear Akt1 for enhanced transcriptional activation of NF-kappaB. (PubMed id 18035048)1, 9 Kwon O....Kim B.Y. (Biochem. Biophys. Res. Commun. 2008)
    137. Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1. (PubMed id 17580302)1, 9 Dong B....Liu R. (J. Biol. Chem. 2007)
    138. Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains. (PubMed id 17635910)1, 9 Cinar B....Freeman M.R. (J. Biol. Chem. 2007)
    139. Dissociation of gemcitabine sensitivity and protein kinase B signaling in pancreatic ductal adenocarcinoma models. (PubMed id 17895832)1, 9 Pham N.A....Hedley D.W. (Pancreas 2007)
    140. Phosphatidylinositol 3-kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation. (PubMed id 17716861)1, 9 Sun L....Zha X. (Cell. Signal. 2007)
    141. Involvement of insulin-like growth factor type 1 receptor and protein kinase Cdelta in bis(maltolato)oxovanadium(IV)-induced phosphorylation of protein kinase B in HepG2 cells. (PubMed id 16981720)1, 9 Mehdi M.Z....Srivastava A.K. (Biochemistry 2006)
    142. Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. (PubMed id 16982699)2, 9 Heron-Milhavet L.... Lamb N.J. (Mol. Cell. Biol. 2006)
    143. Akt1 is dynamically modified with O-GlcNAc following treatments with PUGNAc and insulin-like growth factor-1. (PubMed id 16684529)1, 9 Gandy J.C....Bijur G.N. (FEBS Lett. 2006)
    144. Reversal of multidrug resistance of gastric cancer cells by downregulation of Akt1 with Akt1 siRNA. (PubMed id 17310852)1, 9 Han Z....Fan D. (amp 2006)
    145. Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop. (PubMed id 15998799)1, 9 Song J.J. and Lee Y.J. (J. Cell Biol. 2005)
    146. JNK-interacting protein 1 promotes Akt1 activation. (PubMed id 12783873)1, 9 Kim A.H....Chao M.V. (J. Biol. Chem. 2003)
    147. Binding of protein kinase B to the plakin family member periplakin. (PubMed id 12244133)1, 9 van den Heuvel A.P.... Burgering B.M.T. (J. Cell Sci. 2002)
    148. Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI. (PubMed id 11825911)1, 9 Barry F.A. and Gibbins J.M. (J. Biol. Chem. 2002)
    149. The PI3K-PDK1 connection: more than just a road to PKB. (PubMed id 10698680)1, 9 Vanhaesebroeck B. and Alessi D.R. (Biochem. J. 2000)
    150. Studies on the phosphorylation of protein kinase B by Ca(2+)/calmodulin-dependent protein kinases. (PubMed id 10833263)1, 9 Okuno S....Fujisawa H. (J. Biochem. 2000)
    151. Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophrenia. (PubMed id 16987250)1, 9 Ide M....Yoshikawa T. (J. Neurochem. 2006)
    152. Glucose uptake via glucose transporter 3 by human platelets is regulated by protein kinase B. (PubMed id 16049004)1, 9 Ferreira I.A....Akkerman J.W. (J. Biol. Chem. 2005)
    153. R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho. (PubMed id 15525681)1, 9 Wozniak M.A....Keely P.J. (Mol. Biol. Cell 2005)
    154. Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sib-pair families. (PubMed id 16026766)1, 9 Schwab S.G....Wildenauer D.B. (Biol. Psychiatry 2005)
    155. Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. (PubMed id 14560023)1, 9 Powell D.J....Hundal H.S. (Mol. Cell. Biol. 2003)
    156. Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH. (PubMed id 20102399)1, 9 Kirkegaard T....Bartlett J.M. (Histopathology 2010)
    157. Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase. (PubMed id 20361045)1, 9 Ding Z....Mills G.B. (PLoS ONE 2010)
    158. Suppression of Akt1 expression by small interference RNA inhibits SGC7901 cell growth in vitro and in vivo. (PubMed id 19885581)1, 9 Cui X.W....Zhang Q.Y. (Oncol. Rep. 2009)
    159. Associations between Notch-2, Akt-1 and HER2/neu expression in invasive human breast cancer: a tissue microarray immunophenotypic analysis on 98 patients. (PubMed id 18087195)1, 9 Florena A.M....Franco V. (Pathobiology 2007)
    160. Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4. (PubMed id 16428439)1, 9 Yang C....Kazanietz M.G. (Mol. Cell. Biol. 2006)
    161. Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression. (PubMed id 16775835)1, 9 Xia C....Jiang B.H. (J. Cell. Physiol. 2006)
    162. Arsenite induces endothelial cytotoxicity by down-regulation of vascular endothelial nitric oxide synthase. (PubMed id 16239170)7, 9 Tsou T.C....Chang L.W. (Toxicol. Appl. Pharmacol. 2005)
    163. Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors. (PubMed id 15545269)1, 9 Sugatani T. and Hruska K.A. (J. Biol. Chem. 2005)
    164. Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix. (PubMed id 15306850)1, 9 Feng Q....Cerione R.A. (EMBO J. 2004)
    165. Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1. (PubMed id 12529330)7, 9 He Z....Dong Z. (J. Biol. Chem. 2003)
    166. Hotspot mutations of PIK3CA and AKT1 genes are absent in multiple myeloma. (PubMed id 20022634)1, 9 Ismail S.I....Sughayer M.A. (Leuk. Res. 2010)
    167. Expression of Akt and Mdm2 in human esophageal squamous cell carcinoma. (PubMed id 19124015)1, 9 Takahashi K....Tajiri T. (Exp. Mol. Pathol. 2009)
    168. Expression of p-Akt and COX-2 in gastric adenocarcinomas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric adenocarcinoma and U251 glioma cell growth in vitro and in vivo. (PubMed id 19925030)1, 9 Zhang J....Kang C.S. (amp 2009)
    169. AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51. (PubMed id 19010915)1, 9 Plo I....Lopez B.S. (Cancer Res. 2008)
    170. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. (PubMed id 18676830)1, 9 Stemke-Hale K....Hennessy B.T. (Cancer Res. 2008)
    171. The transforming mutation E17K/AKT1 is not a major event in B-cell-derived lymphoid leukaemias. (PubMed id 18665177)1, 9 Mahmoud I.S....Ismail S.I. (Br. J. Cancer 2008)
    172. Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors. (PubMed id 17804734)1, 9 O'Shaughnessy R.F....Byrne C. (Cancer Res. 2007)
    173. Role of receptor and nonreceptor protein tyrosine kinases in H2O2-induced PKB and ERK1/2 signaling. (PubMed id 17406055)1, 9 Mehdi M.Z....Srivastava A.K. (Cell Biochem. Biophys. 2007)
    174. Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch. (PubMed id 16651639)1, 9 Birukova A.A....Birukov K.G. (Am. J. Pathol. 2006)
    175. Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588. (PubMed id 16141217)1, 9 Katsanakis K.D. and Pillay T.S. (J. Biol. Chem. 2005)
    176. Regulation of protein kinase B tyrosine phosphorylation by thyroid-specific oncogenic RET/PTC kinases. (PubMed id 15994200)1, 9 Jung H.S....Shong M. (Mol. Endocrinol. 2005)
    177. Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes. (PubMed id 15833736)1, 9 Wijayanti N....Immenschuh S. (J. Biol. Chem. 2005)
    178. Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. (PubMed id 12446767)1, 9 Ming X.F....Yang Z. (Mol. Cell. Biol. 2002)
    179. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PubMed id 11707444)1, 9 Laine J.... Noguchi M. (J. Biol. Chem. 2002)
    180. AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K. (PubMed id 19802009)1, 9 Askham J.M....Knowles M.A. (Oncogene 2010)
    181. High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast. (PubMed id 19898424)1, 9 Troxell M.L....Corless C.L. (Mod. Pathol. 2010)
    182. Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations. (PubMed id 20101210)1, 9 Lauring J....Park B.H. (Oncogene 2010)
    183. Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex. (PubMed id 20086095)1, 9 BjA...TaskAcn K. (Mol. Cell. Biol. 2010)
    184. Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts. (PubMed id 20398329)1, 9 Wickenden J.A. and Watson C.J. (Breast Cancer Res. 2010)
    185. Regulation of Akt signaling activation by ubiquitination. (PubMed id 20081374)1, 9 Yang W.L....Lin H.K. (Cell Cycle 2010)
    186. Overcoming amino-Nogo-induced inhibition of cell spreading and neurite outgrowth by 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters. (PubMed id 20018888)1, 9 Deng K....Walsh F.S. (J. Biol. Chem. 2010)
    187. Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma. (PubMed id 19418217)1, 9 Dunlap J....Troxell M.L. (Breast Cancer Res. Treat. 2010)
    188. Functional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of beta-parvin. (PubMed id 20164304)1, 9 Kimura M....Kobayashi E. (J. Cell. Sci. 2010)
    189. AKT1 E17 K pleckstrin homology domain mutation in urothelial carcinoma. (PubMed id 19389506)1, 9 Zilberman D.E....Rechavi G. (Cancer Genet. Cytogenet. 2009)
    190. Expression of selected tumor suppressor and oncogenes in endometrium of women with endometriosis. (PubMed id 19429661)1, 9 Laudanski P....Chyczewski L. (Hum. Reprod. 2009)
    191. Activation-induced degradation of FLIP(L) is mediated via the phosphatidylinositol 3-kinase/Akt signaling pathway in macrophages. (PubMed id 19339247)1, 9 Shi B....Pope R.M. (J. Biol. Chem. 2009)
    192. Inhibitory effects of adenovirus mediated COX-2, Akt1 and PIK3R1 shRNA on the growth of malignant tumor cells in vitro and in vivo. (PubMed id 19639178)1, 9 Fu Y....Wang T. (Int. J. Oncol. 2009)
    193. Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice. (PubMed id 18668138)1, 9 Goren I....Frank S. (J. Invest. Dermatol. 2009)
    194. Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses. (PubMed id 18048359)1, 9 Altman J.K....Platanias L.C. (J. Biol. Chem. 2008)
    195. AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition. (PubMed id 18413665)1, 9 Caporali S....D'Atri S. (Mol. Pharmacol. 2008)
    196. VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation. (PubMed id 18332868)1, 9 Huang J. and Chen J. (Oncogene 2008)
    197. Characterization of Akt overexpression in MiaPaCa-2 cells: prohibitin is an Akt substrate both in vitro and in cells. (PubMed id 18507042)2, 9 Han E.K.... Luo Y. (Anticancer Res. 2008)
    198. AKT1 (E17K) mutation in pancreatic cancer. (PubMed id 18783292)1, 9 Mohamedali A....Kocher H.M. (amp 2008)
    199. Overexpression of Akt1 upregulates glycogen synthase activity and phosphorylation of mTOR in IRS-1 knockdown HepG2 cells. (PubMed id 17721885)1, 9 Varma S. and Khandelwal R.L. (J. Cell. Biochem. 2008)
    200. Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent. (PubMed id 18332138)1, 9 Litherland G.J....Rowan A.D. (J. Biol. Chem. 2008)
    201. The potential role of Akt phosphorylation in human cancers. (PubMed id 18409144)1, 9 Cicenas J. (Int. J. Biol. Markers 2008)
    202. Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair. (PubMed id 18644989)1, 9 Toulany M....Rodemann H.P. (Mol. Cancer Ther. 2008)
    203. Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients. (PubMed id 18204829)1, 9 Cozzone D....Vidal H. (Diabetologia 2008)
    204. Role of Akt isoforms in HGF-induced invasive growth of human salivary gland cancer cells. (PubMed id 18355439)1, 9 Hara S....Hamakawa H. (Biochem. Biophys. Res. Commun. 2008)
    205. Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids. (PubMed id 18676874)1, 9 Birukova A.A....Birukov K.G. (Am. J. Physiol. Lung Cell Mol. Physiol. 2008)
    206. Absence of E17K mutation in the pleckstrin homology domain of AKT1 in gastrointestinal and liver cancers in the Korean population. (PubMed id 18754328)1, 9 Cao Z....Park W.S. (APMIS 2008)
    207. TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells. (PubMed id 19050243)1, 9 Bekeredjian-Ding I....Heeg K. (J. Immunol. 2008)
    208. The Par6alpha/aPKC complex regulates Akt1 activity by phosphorylating Thr34 in the PH-domain. (PubMed id 17335965)1, 9 Weyrich P....Lammers R. (Mol. Cell. Endocrinol. 2007)
    209. Lysophosphatidylcholine mediates melanocyte dendricity through PKCzeta activation. (PubMed id 17024099)1, 9 Scott G.A....Jacobs S.E. (J. Invest. Dermatol. 2007)
    210. Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression. (PubMed id 17577629)1, 9 Gao H....Ma R. (Mol. Cell. Biochem. 2007)
    211. P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. (PubMed id 17565979)1, 9 HernA!ndez-Negrete I....VA!zquez-Prado J. (J. Biol. Chem. 2007)
    212. Regulation of the pro-apoptotic scaffolding protein POSH by Akt. (PubMed id 17535800)1, 9 Lyons T.R....Kassenbrock C.K. (J. Biol. Chem. 2007)
    213. Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor-alpha activity. (PubMed id 17505062)1, 9 Ma Y....Rosen E.M. (Mol. Endocrinol. 2007)
    214. Investigation of interleukin 1beta-mediated regulation of NF-kappaB activation in colonic cells reveals divergence between PKB and PDK-transduced events. (PubMed id 17136479)1, 9 Parhar K....Salh B. (Mol. Cell. Biochem. 2007)
    215. Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses. (PubMed id 17925406)1, 9 Jensen M.... B. (J. Biol. Chem. 2007)
    216. Real-time imaging nuclear translocation of Akt1 in HCC cells. (PubMed id 17400190)1, 9 Zhu L....Gu J. (Biochem. Biophys. Res. Commun. 2007)
    217. FGFR1 over-expression in primary rhabdomyosarcoma tumors is associated with hypomethylation of a 5' CpG island and abnormal expression of the AKT1, NOG, and BMP4 genes. (PubMed id 17696196)1, 9 Goldstein M....Orr-Urtreger A. (amp 2007)
    218. Following the tracks of AKT1 gene. (PubMed id 17921701)1, 9 Vogiatzi P. and Giordano A. (amp 2007)
    219. Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160. (PubMed id 17513702)1, 9 FrA...Wojtaszewski J.F. (Diabetes 2007)
    220. Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway. (PubMed id 17827393)1, 9 Hers I. (Blood 2007)
    221. Activated Akt signaling pathway in invasive ductal carcinoma of the breast: correlation with HER2 overexpression. (PubMed id 17549359)1, 9 Park S.S. and Kim S.W. (Oncol. Rep. 2007)
    222. BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites. (PubMed id 17030608)1, 9 Benjamin D....Moroni C. (Mol. Cell. Biol. 2006)
    223. Expression of caveolin-1 is correlated with Akt-1 in colorectal cancer tissues. (PubMed id 16202996)1, 9 Kim H.A....Lee R.A. (Exp. Mol. Pathol. 2006)
    224. Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway. (PubMed id 16839745)1, 9 Meng Q....Jiang B.H. (Cell. Signal. 2006)
    225. Tryptase activates PKB in inflammatory reaction in ECV304 cells. (PubMed id 16564100)1, 9 Ma Y....Yin L. (Biochim. Biophys. Acta 2006)
    226. Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway. (PubMed id 16849522)1, 9 Pore N....Maity A. (Mol. Cancer Res. 2006)
    227. Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients. (PubMed id 16049961)1, 9 Tokunaga E....Maehara Y. (Int. J. Cancer 2006)
    228. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. (PubMed id 16537497)1, 9 Liu H....Bissell M.J. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    229. CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12. (PubMed id 16114056)1, 9 Chinni S.R....Cher M.L. (Prostate 2006)
    230. Hypoxia-inducible factor-1alpha expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas. (PubMed id 16682946)1, 9 Gort E.H....Shvarts A. (Oncogene 2006)
    231. Protein kinase B inhibits endostatin-induced apoptosis in HUVECs. (PubMed id 16466644)1, 9 Kang H.Y....Kim H.Y. (J. Biochem. Mol. Biol. 2006)
    232. Akt1 contains a functional leucine-rich nuclear export sequence. (PubMed id 15896313)1, 9 Saji M....Ringel M.D. (Biochem. Biophys. Res. Commun. 2005)
    233. Thyroid hormone induces rapid activation of Akt/protein kinase B-mammalian target of rapamycin-p70S6K cascade through phosphatidylinositol 3-kinase in human fibroblasts. (PubMed id 15388791)1, 9 Cao X....Seo H. (Mol. Endocrinol. 2005)
    234. Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. (PubMed id 15806160)1, 9 Sutherland B.W.... Dunn S.E. (Oncogene 2005)
    235. Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120. (PubMed id 15689238)1, 9 Langford D....Masliah E. (BMC Neurosci 2005)
    236. The role of Akt on arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation. (PubMed id 15916724)7, 9 Wang Z.X....Chen Q. (Cell Res. 2005)
    237. Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators. (PubMed id 15911620)1, 9 Song J.J. and Lee Y.J. (J. Biol. Chem. 2005)
    238. Albumin endocytosis in proximal tubule cells is modulated by angiotensin II through an AT2 receptor-mediated protein kinase B activation. (PubMed id 16293694)1, 9 Caruso-Neves C....Guggino W.B. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    239. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. (PubMed id 15808505)1, 9 Gao T.... Newton A.C. (Mol. Cell 2005)
    240. Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2. (PubMed id 15987444)1, 9 Cicenas J....Eppenberger-Castori S. (Breast Cancer Res. 2005)
    241. Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation. (PubMed id 16266983)2, 9 Brandts C.H.... Serve H. (Cancer Res. 2005)
    242. Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors. (PubMed id 15047604)1, 9 Kwon H.S....Harris R.A. (Diabetes 2004)
    243. AKT participates in endothelial dysfunction in hypertension. (PubMed id 15136501)1, 9 Iaccarino G....Trimarco B. (Circulation 2004)
    244. Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration. (PubMed id 15149849)1, 9 Berven L.A....Crouch M.F. (Exp. Cell Res. 2004)
    245. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). (PubMed id 14645242)1, 9 Dan H.C.... Cheng J.Q. (J. Biol. Chem. 2004)
    246. Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes. (PubMed id 15010337)1, 9 Gosmanov A.R....Thomason D.B. (Am. J. Physiol. Endocrinol. Metab. 2004)
    247. The activity of the plexin-A1 receptor is regulated by Rac. (PubMed id 15187088)1, 9 Turner L.J....Hall A. (J. Biol. Chem. 2004)
    248. Normal function of HERG K+ channels expressed in HEK293 cells requires basal protein kinase B activity. (PubMed id 12527373)1, 9 Zhang Y....Wang Z. (FEBS Lett. 2003)
    249. Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation. (PubMed id 12592338)1, 9 Bortul R....Martelli A.M. (Leukemia 2003)
    250. Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. (PubMed id 12964941)2, 9 Milburn C.C....Van Aalten D.M. (Biochem. J. 2003)
    251. Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. (PubMed id 12458207)1, 9 Barthwal M.K....Rana A. (J. Biol. Chem. 2003)
    252. Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1. (PubMed id 12176337)1, 9 Hill M.M....Hemmings B.A. (Curr. Biol. 2002)
    253. Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. (PubMed id 12167664)1, 9 Dan H.C....Cheng J.Q. (J. Biol. Chem. 2002)
    254. Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. (PubMed id 12167717)1, 9 Scheid M.P.... Woodgett J.R. (Mol. Cell. Biol. 2002)
    255. PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2. (PubMed id 11782427)1, 9 Lynch D.K. and Daly R.J. (EMBO J. 2002)
    256. Insulin suppresses transactivation by CAAT/enhancer-binding proteins beta (C/EBPbeta). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPbeta. (PubMed id 11116148)1, 9 Guo S....Unterman T.G. (J. Biol. Chem. 2001)
    257. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). (PubMed id 11154281)1, 9 Brunet A.... Greenberg M.E. (Mol. Cell. Biol. 2001)
    258. Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3. (PubMed id 10491192)1, 9 Masure S.... Richardson A. (Eur. J. Biochem. 1999)
    259. Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function. (PubMed id 10497255)1, 9 Paz K....Zick Y. (J. Biol. Chem. 1999)
    260. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. (PubMed id 10358075)2, 9 Rena G.... Cohen P. (J. Biol. Chem. 1999)
    261. Role of translocation in the activation and function of protein kinase B. (PubMed id 9395488)1, 9 AndjelkoviA8 M....Hemmings B.A. (J. Biol. Chem. 1997)
    262. 3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. (PubMed id 9368760)1, 9 Alessi D.R.... Bownes M. (Curr. Biol. 1997)
    263. Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216. (PubMed id 9373175)1, 9 Shaw M....Alessi D.R. (FEBS Lett. 1997)
    264. Alkylphosphocholines and curcumin induce programmed cell death in cutaneous T-cell lymphoma cell lines. (PubMed id 24225136)1 Yosifov D.Y....Konstantinov S.M. (Leuk. Res. 2014)
    265. Emodin represses TWIST1-induced epithelial-mesenchymal transitions in head and neck squamous cell carcinoma cells by inhibiting the I^-catenin and Akt pathways. (PubMed id 24157255)1 Way T.D....Ho C.T. (Eur. J. Cancer 2014)
    266. Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis. (PubMed id 24458280)1 Douda D.N....Palaniyar N. (Blood 2014)
    267. The contribution of heavy metals in cigarette smoke condensate to malignant transformation of breast epithelial cells and in vivo initiation of neoplasia through induction of a PI3K-AKT-NFI_B cascade. (PubMed id 24099783)1 Mohapatra P....Kundu C.N. (Toxicol. Appl. Pharmacol. 2014)
    268. Soluble E-cadherin: a critical oncogene modulating receptor tyrosine kinases, MAPK and PI3K/Akt/mTOR signaling. (PubMed id 23318419)1 Brouxhon S.M....Ma L. (Oncogene 2014)
    269. AKT1 Gene Mutation Levels Are Correlated with the Type of Dermatologic Lesions in Patients with Proteus Syndrome. (PubMed id 23884311)1 Lindhurst M.J....Biesecker L.G. (J. Invest. Dermatol. 2014)
    270. Significance of Akt activation and AKT gene increases in soft tissue tumors. (PubMed id 24321521)1 Dobashi Y....Ooi A. (Hum. Pathol. 2014)
    271. Bcr-Abl activates AURKA and AURKB in chronic myeloid leukemia cells via AKT signaling. (PubMed id 23934627)1 Yang J....Yokoyama A. (Int. J. Cancer 2014)
    272. Down-regulation of lipid raft-associated onco-proteins via cholesterol-dependent lipid raft internalization in docosahexaenoic acid-induced apoptosis. (PubMed id 24120917)1 Lee E.J....Kim Y.N. (Biochim. Biophys. Acta 2014)
    273. A signal transduction pathway from TGF-I^1 to SKP2 via Akt1 and c-Myc and its correlation with progression in human melanoma. (PubMed id 23792459)1 Qu X....Liu J. (J. Invest. Dermatol. 2014)
    274. In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated I^1 integrin and induction of FAK/PI3K/Akt motility signaling. (PubMed id 23208492)1 Casar B....Deryugina E.I. (Oncogene 2014)
    275. Dengue virus subgenomic RNA induces apoptosis through the Bcl-2-mediated PI3k/Akt signaling pathway. (PubMed id 24314632)1 Liu Y....Yuan Z. (Virology 2014)
    276. Molecular cross talk between Notch1, Shh and Akt pathways during erythroid differentiation of K562 and HEL cell lines. (PubMed id 24095799)1 Roy A....Banerjee S. (Exp. Cell Res. 2014)
    277. PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma. (PubMed id 23840064)1 Pfeifer M....Lenz G. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    278. RAF1-MEK1-ERK/AKT axis may confer NSCLC cell lines resistance to erlotinib. (PubMed id 23923067)1 Xu Z.H....Gao B.L. (Int J Clin Exp Pathol 2013)
    279. Survey of activated kinase proteins reveals potential targets for cholangiocarcinoma treatment. (PubMed id 23812726)1 Dokduang H....Loilome W. (Tumour Biol. 2013)
    280. Absence of human papillomavirus infection and activation of PI3K-AKT pathway in cervical clear cell carcinoma. (PubMed id 23792604)1 Ueno S....Nishimura R. (Int. J. Gynecol. Cancer 2013)
    281. Photofrin based photodynamic therapy and miR-99a transfection inhibited FGFR3 and PI3K/Akt signaling mechanisms to control growth of human glioblastoma In vitro and in vivo. (PubMed id 23409016)1 Chakrabarti M....Ray S.K. (PLoS ONE 2013)
    282. A novel function of protein kinase B as an inducer of the mismatch repair gene hPMS2 degradation. (PubMed id 23499907)1 Jia J....Wang Z. (Cell. Signal. 2013)
    283. Fas apoptosis inhibitory molecule is upregulated by IGF-1 signaling and modulates Akt activation and IRF4 expression in multiple myeloma. (PubMed id 23138182)1 Huo J....Lam K.P. (Leukemia 2013)
    284. Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids. (PubMed id 23457334)1 Novellasdemunt L....Rosa J.L. (J. Biol. Chem. 2013)
    285. mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells. (PubMed id 23092880)1 Le Bacquer O....Pattou F. (J. Endocrinol. 2013)
    286. Multinucleation regulated by the Akt/PTEN signaling pathway is a survival strategy for HepG2 cells. (PubMed id 23796964)1 Mukherjee A....Karmakar P. (Mutat. Res. 2013)
    287. The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression. (PubMed id 23430973)1 Bertacchini J....Marmiroli S. (FASEB J. 2013)
    288. Genetic variation in AKT1, PTEN and the 8q24 locus, and the risk of testicular germ cell tumor. (PubMed id 23639623)1 Andreassen K.E....Grotmol T. (Hum. Reprod. 2013)
    289. The expression of chitinase 3-like 1: a novel prognostic predictor for hepatocellular carcinoma. (PubMed id 23525579)1 Pan J.J....Liu W.B. (J. Cancer Res. Clin. Oncol. 2013)
    290. Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response. (PubMed id 23195959)1 Fan C.D....Wang X. (J. Biol. Chem. 2013)
    291. Gene expression profiling in treatment-naive schizophrenia patients identifies abnormalities in biological pathways involving AKT1 that are corrected by antipsychotic medication. (PubMed id 23442539)1 Kumarasinghe N....Tooney P.A. (Int. J. Neuropsychopharmacol. 2013)
    292. Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway. (PubMed id 23686362)1 Sandri M....Schiaffino S. (Biogerontology 2013)
    293. Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy. (PubMed id 23169238)1 Huang H....Zhao Z. (Autophagy 2013)
    294. Glutathione prevents free fatty acids-induced oxidative stress and apoptosis in human brain vascular endothelial cells through Akt pathway. (PubMed id 23521913)1 Zhou H.G....Dong Q. (amp 2013)
    295. AKT isoforms 1 and 3 regulate basal and epidermal growth factor-stimulated SGHPL-5 trophoblast cell migration in humans. (PubMed id 23303682)1 Haslinger P....KnAPfler M. (Biol. Reprod. 2013)
    296. Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. (PubMed id 23348505)1 Clark V.E....GA1nel M. (Science 2013)
    297. The AKT1/NF-kappaB/Notch1/PTEN axis has an important role in chemoresistance of gastric cancer cells. (PubMed id 24113181)1 Zhou W....Yu H.G. (amp 2013)
    298. Contactin-1 reduces E-cadherin expression via activating AKT in lung cancer. (PubMed id 23724143)1 Yan J....Tang D. (PLoS ONE 2013)
    299. Lactotransferrin acts as a tumor suppressor in nasopharyngeal carcinoma by repressing AKT through multiple mechanisms. (PubMed id 23069661)1 Deng M....Li G. (Oncogene 2013)
    300. Positive feedback regulation of heat shock protein 70 (Hsp70) is mediated through Toll-like receptor 4-PI3K/Akt-glycogen synthase kinase-3I^ pathway. (PubMed id 23043959)1 Lee K.H....Yoo C.G. (Exp. Cell Res. 2013)
    301. The microRNA-302-367 cluster suppresses the proliferation of cervical carcinoma cells through the novel target AKT1. (PubMed id 23185040)1 Cai N....Zheng P.S. (RNA 2013)
    302. SLIT2 inhibits cell migration in colorectal cancer through the AKT-GSK3I^ signaling pathway. (PubMed id 23314850)1 Chen W.F....Yao L.Q. (Int J Colorectal Dis 2013)
    303. TRAF4 is a critical molecule for Akt activation in lung cancer. (PubMed id 24154876)1 Li W....Dong Z. (Cancer Res. 2013)
    304. Loss of fatty acid synthase inhibits the &quot;HER2-PI3K/Akt axis&quot; activity and malignant phenotype of Caco-2 cells. (PubMed id 23725225)1 Li N....Huang P. (Lipids Health Dis 2013)
    305. ADAM17 mediates hypoxia-induced drug resistance in hepatocellular carcinoma cells through activation of EGFR/PI3K/Akt pathway. (PubMed id 23625205)1 Wang X.J....Li M. (Mol. Cell. Biochem. 2013)
    306. Reactivation of AKT signaling following treatment of cancer cells with PI3K inhibitors attenuates their antitumor effects. (PubMed id 23867821)1 Dufour M....Dormond O. (Biochem. Biophys. Res. Commun. 2013)
    307. Glioma is formed by active Akt1 alone and promoted by active Rac1 in transgenic zebrafish. (PubMed id 23325864)1 Jung I.H....Park S.W. (Neuro-oncology 2013)
    308. Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism. (PubMed id 23624506)1 Yang Y.L....Chen C.S. (Biochem. Biophys. Res. Commun. 2013)
    309. Nir1 promotes invasion of breast cancer cells by binding to chemokine (C-C motif) ligand 18 through the PI3K/Akt/GSK3I^/Snail signalling pathway. (PubMed id 24001613)1 Zhang B....Qi Y. (Eur. J. Cancer 2013)
    310. The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer. (PubMed id 22391563)1 Li X....Gao T. (Oncogene 2013)
    311. Overexpression of AKT decreases the chemosensitivity of gastric cancer cells to cisplatin inA vitro and inA vivo. (PubMed id 23546174)1 Zhang L.L....Yu H.G. (Mol Med Rep 2013)
    312. Akt kinase mediates the prosurvival effect of smoking compounds in pancreatic ductal cells. (PubMed id 23271397)1 Park C.H....Edderkaoui M. (Pancreas 2013)
    313. Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca(2+)-dependent pathway. (PubMed id 23261389)1 Figueroa V....Retamal M.A. (Biochim. Biophys. Acta 2013)
    314. Functional screen analysis reveals miR-26b and miR-128 as central regulators of pituitary somatomammotrophic tumor growth through activation of the PTEN-AKT pathway. (PubMed id 22614013)1 Palumbo T....Stratakis C.A. (Oncogene 2013)
    315. Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA. (PubMed id 24297901)1 Nguyen l.e. .X.T. and Mitchell B.S. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    316. MicroRNA-451 inhibits growth of human colorectal carcinoma cells via downregulation of Pi3k/Akt pathway. (PubMed id 23886157)1 Li H.Y....Bian H.L. (Asian Pac. J. Cancer Prev. 2013)
    317. Marine algal carotenoids inhibit angiogenesis by down-regulating FGF-2-mediated intracellular signals in vascular endothelial cells. (PubMed id 23613227)1 Ganesan P....Hirata T. (Mol. Cell. Biochem. 2013)
    318. AKT collaborates with ERG and Gata1s to dysregulate megakaryopoiesis and promote AMKL. (PubMed id 23380710)1 Stankiewicz M.J. and Crispino J.D. (Leukemia 2013)
    319. Dual phosphorylation of Btk by Akt/protein kinase b provides docking for 14-3-3IP, regulates shuttling, and attenuates both tonic and induced signaling in B cells. (PubMed id 23754751)1 Mohammad D.K....Smith C.I. (Mol. Cell. Biol. 2013)
    320. microRNA-133a regulates the cell cycle and proliferation of breast cancer cells by targeting epidermal growth factor receptor through the EGFR/Akt signaling pathway. (PubMed id 23786162)1 Cui W....Zhou Z. (FEBS J. 2013)
    321. Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis. (PubMed id 24005670)1 Cao H....Xiao G. (J. Biol. Chem. 2013)
    322. Basic fibroblast growth factor upregulates survivin expression in hepatocellular carcinoma cells via a protein kinase B-dependent pathway. (PubMed id 23677479)1 Sun B....Hou G. (Oncol. Rep. 2013)
    323. Induction of CCL8/MCP-2 by mycobacteria through the activation of TLR2/PI3K/Akt signaling pathway. (PubMed id 23418602)1 Liu H....Ge B. (PLoS ONE 2013)
    324. Phase II trial of MEK inhibitor selumetinib (AZD6244, ARRY-142886) in patients with BRAFV600E/K-mutated melanoma. (PubMed id 23444215)1 Catalanotti F....Chapman P.B. (Clin. Cancer Res. 2013)
    325. Inhibition of constitutively activated phosphoinositide 3-kinase/AKT pathway enhances antitumor activity of chemotherapeutic agents in breast cancer susceptibility gene 1-defective breast cancer cells. (PubMed id 22488590)1 Yi Y.W....Bae I. (Mol. Carcinog. 2013)
    326. CDK inhibitor p57 (Kip2) is downregulated by Akt during HER2-mediated tumorigenicity. (PubMed id 23421998)1 Zhao R....Lee M.H. (Cell Cycle 2013)
    327. Oncogenic B-Raf(V600E) abrogates the AKT/B-Raf/Mps1 interaction in melanoma cells. (PubMed id 23726842)1 Zhang L....Cui Y. (Cancer Lett. 2013)
    328. Negative regulation of the RalGAP complex by 14-3-3. (PubMed id 23386617)1 Leto D....Saltiel A.R. (J. Biol. Chem. 2013)
    329. Increased phosphorylation of AKT in high-risk gastric mucosa. (PubMed id 23898095)1 Sasaki T....Yamashita Y. (Anticancer Res. 2013)
    330. AKT1 fails to replicate as a longevity-associated gene in Danish and German nonagenarians and centenarians. (PubMed id 22929028)1 Nygaard M....Christiansen L. (Eur. J. Hum. Genet. 2013)
    331. Asymmetric dimethylarginine induces endothelial nitric-oxide synthase mitochondrial redistribution through the nitration-mediated activation of Akt1. (PubMed id 23255608)1 Rafikov R....Black S.M. (J. Biol. Chem. 2013)
    332. AIB1 predicts bladder cancer outcome and promotes bladder cancer cell proliferation through AKT and E2F1. (PubMed id 23511556)1 Tong Z.T....Luo J.H. (Br. J. Cancer 2013)
    333. Enrichment of ovarian cancer stem-like cells is associated with epithelial to mesenchymal transition through an miRNA-activated AKT pathway. (PubMed id 23869765)1 Luo X....Lai D. (Cell Prolif. 2013)
    334. Angiogenin in Parkinson disease models: role of Akt phosphorylation and evaluation of AAV-mediated angiogenin expression in MPTP treated mice. (PubMed id 23409128)1 Steidinger T.U....Yacoubian T.A. (PLoS ONE 2013)
    335. Development of Akt-activated GSK3I^ inhibitory peptide. (PubMed id 23583197)1 Kim J.S....Ha N.C. (Biochem. Biophys. Res. Commun. 2013)
    336. c-Src regulates cell cycle proteins expression through protein kinase B/glycogen synthase kinase 3 beta and extracellular signal-regulated kinases 1/2 pathways in MCF-7 cells. (PubMed id 23615537)1 Liu X....Feng R. (Acta Biochim. Biophys. Sin. (Shanghai) 2013)
    337. Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology. (PubMed id 23852728)1 Betz C....Hall M.N. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    338. Phosphoinositide 3-kinase I^ inhibits cardiac GSK-3 independently of Akt. (PubMed id 23354687)1 Mohan M.L....Naga Prasad S.V. (Sci Signal 2013)
    339. The PTEN-Akt pathway impacts the integrity and composition of mitotic centrosomes. (PubMed id 23574721)1 Leonard M.K....Kadakia M.P. (Cell Cycle 2013)
    340. A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. (PubMed id 23459592)1 Read R.D....Thomas J.B. (PLoS Genet. 2013)
    341. AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve. (PubMed id 23757022)1 Er E.E....Blenis J. (Sci Signal 2013)
    342. SGT1 regulates Akt signaling by promoting beta-TrCP-dependent PHLPP1 degradation in gastric cancer cells. (PubMed id 23440515)1 Gao G....Zhang X. (Mol. Biol. Rep. 2013)
    343. AKT primes snail-induced EMT concomitantly with the collective migration of squamous cell carcinoma cells. (PubMed id 23553960)1 Okui G....Kamata N. (J. Cell. Biochem. 2013)
    344. Hydrogen peroxide inhibits transforming growth factor-I^1-induced cell cycle arrest by promoting Smad3 linker phosphorylation through activation of Akt-ERK1/2-linked signaling pathway. (PubMed id 23685151)1 Choi J....Kim B.C. (Biochem. Biophys. Res. Commun. 2013)
    345. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. (PubMed id 23563706)1 Meng Z.X....Lin J.D. (Nat. Med. 2013)
    346. Akt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization. (PubMed id 24081328)1 Liu K....Lin W.C. (Mol. Cell. Biol. 2013)
    347. Akt/mTOR signalling in myelination. (PubMed id 23863161)1 NorrmAcn C. and Suter U. (Biochem. Soc. Trans. 2013)
    348. Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice. (PubMed id 22923366)1 Abekhoukh S....Janel N. (Mol. Neurobiol. 2013)
    349. Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways. (PubMed id 23561972)1 Zhang J.G....Wang C.Y. (Pancreatology 2013)
    350. Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling. (PubMed id 23300340)1 Yang W.L....Lin H.K. (Sci Signal 2013)
    351. Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. (PubMed id 23334667)1 Brastianos P.K....Beroukhim R. (Nat. Genet. 2013)
    352. Platelet-derived growth factor-BB activates calcium/calmodulin-dependent and -independent mechanisms that mediate Akt phosphorylation in the neurofibromin-deficient human Schwann cell line ST88-14. (PubMed id 23457304)1 Farrer R.G....DeVries G.H. (J. Biol. Chem. 2013)
    353. Interleukin-6 upregulates paraoxonase 1 gene expression via an AKT/NF-I_B-dependent pathway. (PubMed id 23791833)1 Cheng C.C....Hsu S.L. (Biochem. Biophys. Res. Commun. 2013)
    354. Casitas B-lineage lymphoma mutants activate AKT to induce transformation in cooperation with class III receptor tyrosine kinases. (PubMed id 23127761)1 Polzer H....Spiekermann K. (Exp. Hematol. 2013)
    355. Activation of the small G-protein Rac by human rhinovirus attenuates the TLR3/IFN-I+ axis while promoting CCL2 release in human monocyte-lineage cells. (PubMed id 23060458)1 Schreiber M.T....Hall D.J. (Innate Immun 2013)
    356. Akt kinase targets the association of CBP with histone H3 to regulate the acetylation of lysine K18. (PubMed id 23434580)1 Liu Y....Fang Y. (FEBS Lett. 2013)
    357. Cancer associated E17K mutation causes rapid conformational drift in AKT1 pleckstrin homology (PH) domain. (PubMed id 23741320)1 Kumar A. and Purohit R. (PLoS ONE 2013)
    358. AKT inhibition mitigates GRP78 (glucose-regulated protein) expression and contribution to chemoresistance in endometrial cancers. (PubMed id 23280503)1 Gray M.J....Lin Y.G. (Int. J. Cancer 2013)
    359. MOZ increases p53 acetylation and premature senescence through its complex formation with PML. (PubMed id 23431171)2 Rokudai S....Prives C. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    360. ROS-mediated activation of AKT induces apoptosis via pVHL in prostate cancer cells. (PubMed id 23315288)1 Chetram M.A....Hinton C.V. (Mol. Cell. Biochem. 2013)
    361. Pkb/Akt1 mediates Wnt/GSK3I^/I^-catenin signaling-induced apoptosis in human cord blood stem cells exposed to organophosphate pesticide monocrotophos. (PubMed id 22897592)1 Kashyap M.P....Pant A.B. (Stem Cells Dev. 2013)
    362. Nicotinamide N-methyltransferase overexpression is associated with Akt phosphorylation and indicates worse prognosis in patients with nasopharyngeal carcinoma. (PubMed id 23838801)1 Win K.T....Li C.F. (Tumour Biol. 2013)
    363. A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung cancer: correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features. (PubMed id 23728071)1 Trigka E.A....Korkolopoulou P. (Oncol. Rep. 2013)
    364. MicroRNA-7-regulated TLR9 signaling-enhanced growth and metastatic potential of human lung cancer cells by altering the phosphoinositide-3-kinase, regulatory subunit 3/Akt pathway. (PubMed id 23135998)1 Xu L....Ren T. (Mol. Biol. Cell 2013)
    365. HuR inhibits apoptosis by amplifying Akt signaling through a positive feedback loop. (PubMed id 22674407)1 Singh M....Lee B.S. (J. Cell. Physiol. 2013)
    366. Inhibition of the PI3K/Akt pathway increases the chemosensitivity of gastric cancer to vincristine. (PubMed id 23743572)1 Xie X....Zhang P. (Oncol. Rep. 2013)
    367. Distinct and specific roles of AKT1 and AKT2 in androgen-sensitive and androgen-independent prostate cancer cells. (PubMed id 23567263)1 Cariaga-Martinez A.E....ColA!s B. (Cell. Signal. 2013)
    368. Overexpression of 4EBP1, p70S6K, Akt1 or Akt2 differentially promotes Coxsackievirus B3-induced apoptosis in HeLa cells. (PubMed id 24030155)1 Li X....Yang Z. (amp 2013)
    369. miRNA-200c increases the sensitivity of breast cancer cells to doxorubicin through the suppression of E-cadherin-mediated PTEN/Akt signaling. (PubMed id 23546450)1 Chen Y....Liu W. (Mol Med Rep 2013)
    370. Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma. (PubMed id 23824745)1 Zeng L....Cohen H.T. (Cancer Res. 2013)
    371. Chronic low-dose radiation inhibits the cells death by cytotoxic high-dose radiation increasing the level of AKT and acinus proteins via NF-I_B activation. (PubMed id 23205493)1 Park H.S....Nam S.Y. (Int. J. Radiat. Biol. 2013)
    372. A genetic variant of the anti-apoptotic protein Akt predicts natalizumab-induced lymphocytosis and post-natalizumab multiple sclerosis reactivation. (PubMed id 22577119)1 Rossi S....Centonze D. (Mult. Scler. 2013)
    373. Inhibition of protein synthesis alters protein degradation through activation of protein kinase B (AKT). (PubMed id 23843462)1 Dai C.L....Gong C.X. (J. Biol. Chem. 2013)
    374. Akt and c-Myc induce stem-cell markers in mature primary p53a8>/a8> astrocytes and render these cells gliomagenic in the brain of immunocompetent mice. (PubMed id 23424671)1 Radke J....Pagenstecher A. (PLoS ONE 2013)
    375. IGF-I signaling is essential for FSH stimulation of AKT and steroidogenic genes in granulosa cells. (PubMed id 23340251)1 Zhou P....Stocco C. (Mol. Endocrinol. 2013)
    376. The AKT1 gene is associated with attention and brain morphology in schizophrenia. (PubMed id 22150081)1 Ohi K....Takeda M. (World J. Biol. Psychiatry 2013)
    377. Transcriptional regulation of serine/threonine protein kinase (AKT) genes by glioma-associated oncogene homolog 1. (PubMed id 23580656)1 Agarwal N.K....Vega F. (J. Biol. Chem. 2013)
    378. Increased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy. (PubMed id 23832540)1 Yothaisong S....Loilome W. (Tumour Biol. 2013)
    379. Scutellaria barbata D. Don induces G1/S arrest via modulation of p53 and Akt pathways in human colon carcinoma cells. (PubMed id 23354912)1 Wei L....Peng J. (Oncol. Rep. 2013)
    380. Dexamethasone inhibits podocyte apoptosis by stabilizing the PI3K/Akt signal pathway. (PubMed id 23710442)1 Yu-Shengyou . and Li Y. (Biomed Res Int 2013)
    381. Correlation of breast cancer axillary lymph node metastases with stem cell mutations. (PubMed id 23884447)1 Donovan C.A....Pommier S.J. (JAMA Surg 2013)
    382. Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells. (PubMed id 23389849)1 Pande S....Stein G.S. (J. Cell. Physiol. 2013)
    383. Stromal cell-derived factor-1 (SDF-1) enhances cells invasion by I+vI^6 integrin-mediated signaling in ovarian cancer. (PubMed id 23615713)1 Xue B....Yu Y. (Mol. Cell. Biochem. 2013)
    384. The PI3K/AKT/mTOR signaling pathway is overactivated in primary aldosteronism. (PubMed id 23626817)1 Su H....Sun F. (PLoS ONE 2013)
    385. Akt SUMOylation regulates cell proliferation and tumorigenesis. (PubMed id 23884910)1 Li R....Wang P. (Cancer Res. 2013)
    386. Increased insulin receptor substrate 2 expression is associated with steatohepatitis and altered lipid metabolism in obese subjects. (PubMed id 23147115)1 Rametta R....Valenti L. (Int J Obes (Lond) 2013)
    387. Up-regulation of the inwardly rectifying Ka8_ channel Kir2.1 (KCNJ2) by protein kinase B (PKB/Akt) and PIKfyve. (PubMed id 23188060)1 Munoz C....Lang F. (J. Membr. Biol. 2013)
    388. Selective Akt inhibitors synergize with tyrosine kinase inhibitors and effectively override stroma-associated cytoprotection of mutant FLT3-positive AML cells. (PubMed id 23437141)1 Weisberg E....Gray N. (PLoS ONE 2013)
    389. Vascular endothelial growth factor induces multidrug resistance-associated protein 1 overexpression through phosphatidylinositol-3-kinase /protein kinase B signaling pathway and transcription factor specificity protein 1 in BGC823 cell line. (PubMed id 23765166)1 Li J....Xu W. (Acta Biochim. Biophys. Sin. (Shanghai) 2013)
    390. Withaferin A inhibits matrix metalloproteinase-9 activity by suppressing the Akt signaling pathway. (PubMed id 23708780)1 Lee D.H....Lee T.J. (Oncol. Rep. 2013)
    391. RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis. (PubMed id 23135917)1 Kazerounian S....Benjamin L.E. (Cancer Res. 2013)
    392. Roles of EGFR, PI3K, AKT, and mTOR in heavy metal-induced cancer. (PubMed id 23297824)1 Carpenter R.L. and Jiang B.H. (Curr Cancer Drug Targets 2013)
    393. Circulating vascular endothelial growth factor receptor 2/pAkt-positive cells as a functional pharmacodynamic marker in metastatic colorectal cancers treated with antiangiogenic agent. (PubMed id 22539090)1 Shin S.J....Chung H.C. (Invest New Drugs 2013)
    394. Molecular dissection of AKT activation in lung cancer cell lines. (PubMed id 23319332)1 Guo Y....Kwiatkowski D.J. (Mol. Cancer Res. 2013)
    395. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    396. Notch1 receptor regulates AKT protein activation loop (Thr308) dephosphorylation through modulation of the PP2A phosphatase in phosphatase and tensin homolog (PTEN)-null T-cell acute lymphoblastic leukemia cells. (PubMed id 23788636)1 Hales E.C....Matherly L.H. (J. Biol. Chem. 2013)
    397. Upregulation of genes for C-reactive protein and related pentraxin/complement proteins in photodynamic therapy-treated human tumor cells: enrolment of PI3K/Akt and AP-1. (PubMed id 23182717)1 Merchant S. and Korbelik M. (Immunobiology 2013)
    398. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    399. Characterization of heparanase-induced phosphatidylinositol 3-kinase-AKT activation and its integrin dependence. (PubMed id 23504323)1 Riaz A....Johansson S. (J. Biol. Chem. 2013)
    400. Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression. (PubMed id 23896866)1 Kshirsagar S....Edelbauer M. (Arthritis Rheum. 2013)
    401. Downregulation of Src enhances the cytotoxic effect of temozolomide through AKT in glioma. (PubMed id 23338526)1 Wang Z....Yang W. (Oncol. Rep. 2013)
    402. Suppression of survival signalling pathways by the phosphatase PHLPP. (PubMed id 22340730)1 O'Neill A.K....Newton A.C. (FEBS J. 2013)
    403. Akt inhibition promotes hexokinase 2 redistribution and glucose uptake in cancer cells. (PubMed id 23629924)1 Neary C.L. and Pastorino J.G. (J. Cell. Physiol. 2013)
    404. 15-lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation. (PubMed id 23474367)1 Ma J....Zhu D. (amp 2013)
    405. Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine. (PubMed id 23237847)1 Yi K.H....Lauring J. (Oncotarget 2013)
    406. HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression. (PubMed id 23507869)1 Cheshenko N....Herold B.C. (FASEB J. 2013)
    407. Downregulation of Erbin in Her2-overexpressing breast cancer cells promotes cell migration and induces trastuzumab resistance. (PubMed id 23711387)1 Liu D....Guo N. (Mol. Immunol. 2013)
    408. Hypoxia regulation of phosphokinases and the prognostic value of pAKT in breast cancer. (PubMed id 23558942)1 Wennemers M....Span P.N. (Int. J. Biol. Markers 2013)
    409. ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer. (PubMed id 22907434)1 Du W....Yu J. (Oncogene 2013)
    410. Moscatilin inhibits migration and metastasis of human breast cancer MDA-MB-231 cells through inhibition of Akt and Twist signaling pathway. (PubMed id 22961111)1 Pai H.C....Pan S.L. (J. Mol. Med. 2013)
    411. Critical roles for Akt kinase in controlling HIV envelope-mediated depletion of CD4 T cells. (PubMed id 23742646)1 Li H. and Pauza C.D. (Retrovirology 2013)
    412. Polyethylene glycated leukemia inhibitory factor antagonist inhibits human blastocyst implantation and triggers apoptosis by down-regulating embryonic AKT. (PubMed id 23876532)1 Lalitkumar S....Lalitkumar L.P. (Fertil. Steril. 2013)
    413. Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1. (PubMed id 23512990)1 Huang P.H....Chen C.S. (Sci Signal 2013)
    414. Protein kinase B/Akt1 inhibits autophagy by down-regulating UVRAG expression. (PubMed id 23200933)1 Yang W....Shin I. (Exp. Cell Res. 2013)
    415. Knockdown of the cochaperone SGTA results in the suppression of androgen and PI3K/Akt signaling and inhibition of prostate cancer cell proliferation. (PubMed id 23740762)1 Trotta A.P....Buchanan G. (Int. J. Cancer 2013)
    416. PIK3CA-AKT pathway mutations in micropapillary breast carcinoma. (PubMed id 23352210)1 Flatley E....Troxell M.L. (Hum. Pathol. 2013)
    417. TLR3-mediated apoptosis and activation of phosphorylated Akt in the salivary gland epithelial cells of primary SjAPgren's syndrome patients. (PubMed id 22457005)1 Nakamura H....Kawakami A. (Rheumatol. Int. 2013)
    418. Varicella-zoster virus ORF12 protein activates the phosphatidylinositol 3-kinase/Akt pathway to regulate cell cycle progression. (PubMed id 23192871)1 Liu X. and Cohen J.I. (J. Virol. 2013)
    419. CIB1 prevents nuclear GAPDH accumulation and non-apoptotic tumor cell death via AKT and ERK signaling. (PubMed id 22964641)1 Leisner T.M....Parise L.V. (Oncogene 2013)
    420. The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53. (PubMed id 23841076)1 Shin S....Lim K. (Biomed Res Int 2013)
    421. GLP-1 promotes angiogenesis in human endothelial cells in a dose-dependent manner, through the Akt, Src and PKC pathways. (PubMed id 23684008)1 Aronis K.N....Mantzoros C.S. (Metab. Clin. Exp. 2013)
    422. Sodium valproate potentiates staurosporine-induced apoptosis in neuroblastoma cells via Akt/survivin independently of HDAC inhibition. (PubMed id 23097134)1 Shah R.D....Shastry P. (J. Cell. Biochem. 2013)
    423. Heterogeneity of neuroblastoma cell lines in insulin-like growth factor 1 receptor/Akt pathway-mediated cell proliferative responses. (PubMed id 23710710)1 Qi L....Komada Y. (Cancer Sci. 2013)
    424. 17I^-estradiol activates glucose uptake via GLUT4 translocation and PI3K/Akt signaling pathway in MCF-7 cells. (PubMed id 23546602)1 Garrido P....GonzA!lez C. (Endocrinology 2013)
    425. RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation. (PubMed id 23419514)1 Lee J.T....Gu W. (Cell Res. 2013)
    426. Markers CD40, VEGF, AKT, PI3K, and S100 correlate with tumor stage in gastric cancer. (PubMed id 23429328)1 Tian W.Y....Liu L. (Onkologie 2013)
    427. Akt1 enhances CA916798 expression through mTOR pathway. (PubMed id 23667466)1 Wang Y.L....Zhou X.D. (PLoS ONE 2013)
    428. PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage. (PubMed id 22975685)1 Li Y....Park J. (Cell. Signal. 2013)
    429. Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway. (PubMed id 23563091)1 Gao A.M....Chen H. (Carcinogenesis 2013)
    430. Inhibition of the PI3K/AKT-NF-I_B pathway with curcumin enhanced radiation-induced apoptosis in human Burkitt's lymphoma. (PubMed id 23603894)1 Qiao Q....Li G. (J. Pharmacol. Sci. 2013)
    431. An emerging role for Wnt and GSK3 signaling pathways in schizophrenia. (PubMed id 23379509)1 Singh K.K. (Clin. Genet. 2013)
    432. Sorafenib induces endometrial carcinoma apoptosis by inhibiting Elk-1-dependent Mcl-1 transcription and inducing Akt/GSK3I^-dependent protein degradation. (PubMed id 23463670)1 Sun N.K....Chao C.C. (J. Cell. Biochem. 2013)
    433. Caffeic acid phenethyl ester suppresses melanoma tumor growth by inhibiting PI3K/AKT/XIAP pathway. (PubMed id 23640046)1 Pramanik K.C....Srivastava S.K. (Carcinogenesis 2013)
    434. Endothelial microparticles increase in mitral valve disease and impair mitral valve endothelial function. (PubMed id 23384770)1 Ci H.B....Ou J.S. (Am. J. Physiol. Endocrinol. Metab. 2013)
    435. A comparison between manual and automated evaluations of tissue microarray patterns of protein expression. (PubMed id 23340270)1 Alvarenga A.W....Hajj G.N. (J. Histochem. Cytochem. 2013)
    436. Protective effect of allograft inflammatory factor-1 on the apoptosis of fibroblast-like synoviocytes in patients with rheumatic arthritis induced by nitro oxide donor sodium nitroprusside. (PubMed id 23547889)1 Liu Y....Shen L. (Scand. J. Rheumatol. 2013)
    437. The G protein-coupled receptor GPR30 mediates the nontranscriptional effect of estrogen on the activation of PI3K/Akt pathway in endometrial cancer cells. (PubMed id 23235274)1 Ge X....Hu D. (Int. J. Gynecol. Cancer 2013)
    438. DUOX enzyme activity promotes AKT signalling in prostate cancer cells. (PubMed id 23225414)1 Pettigrew C.A....Cotter T.G. (Anticancer Res. 2012)
    439. Clinicopathological correlations of mTOR and pAkt expression in non-small cell lung cancer. (PubMed id 22562131)1 Oh M.H....Chung J.H. (Virchows Arch. 2012)
    440. Integrin I+IIb-mediated PI3K/Akt activation in platelets. (PubMed id 23082158)1 Niu H....Liu J. (PLoS ONE 2012)
    441. Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/MicroRNA-21 pathway. (PubMed id 23272133)1 Sheth S....Ramkumar V. (PLoS ONE 2012)
    442. Molecular alterations in AKT and its protein activation in human lung carcinomas. (PubMed id 22748472)1 Dobashi Y....Ooi A. (Hum. Pathol. 2012)
    443. MEK inhibition leads to PI3K/AKT activation by relieving a negative feedback on ERBB receptors. (PubMed id 22552284)1 Turke A.B....Engelman J.A. (Cancer Res. 2012)
    444. Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling. (PubMed id 22629392)2 Wang S.... Geng M. (PLoS ONE 2012)
    445. JNK- and Akt-mediated Puma expression in the apoptosis of cisplatin-resistant ovarian cancer cells. (PubMed id 22394200)1 Zhao Z....Wei Y. (Biochem. J. 2012)
    446. ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. (PubMed id 22351695)1 Chapman C.M....Wiestner A. (Clin. Cancer Res. 2012)
    447. Dysadherin expression promotes the motility and survival of human breast cancer cells by AKT activation. (PubMed id 22494103)1 Lee Y.K....Nam J.S. (Cancer Sci. 2012)
    448. Overexpression of the I1-opioid receptor in human non-small cell lung cancer promotes Akt and mTOR activation, tumor growth, and metastasis. (PubMed id 22343475)1 Lennon F.E....Singleton P.A. (Anesthesiology 2012)
    449. Zerumbone suppresses IKKI+, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells. (PubMed id 23035900)1 Weng H.Y....Lin C.H. (J. Biomed. Sci. 2012)
    450. Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase. (PubMed id 22184110)1 Das F....Choudhury G.G. (J. Biol. Chem. 2012)
    451. Akt mediates metastasis-associated gene 1 (MTA1) regulating the expression of E-cadherin and promoting the invasiveness of prostate cancer cells. (PubMed id 23227138)1 Wang H....Wang C. (PLoS ONE 2012)
    452. Effects of simulated microgravity on human umbilical vein endothelial cell angiogenesis and role of the PI3K-Akt-eNOS signal pathway. (PubMed id 22808143)1 Shi F....Sun X.Q. (PLoS ONE 2012)
    453. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    454. Concurrent blockade of NF-I_B and Akt pathways potentiates cisplatin's antitumor activity in vivo. (PubMed id 22760211)1 Sun H....Wang X. (Anticancer Drugs 2012)
    455. High-resolution melting analysis as a sensitive prescreening diagnostic tool to detect KRAS , BRAF , PIK3CA , and AKT1 mutations in formalin-fixed, paraffin-embedded tissues. (PubMed id 22938585)1 Ney J.T....Merkelbach-Bruse S. (amp 2012)
    456. Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells. (PubMed id 22535956)1 Lo RAc A.E....Fernandez-Zapico M.E. (J. Biol. Chem. 2012)
    457. Silencing of ETV6/RUNX1 abrogates PI3K/AKT/mTOR signaling and impairs reconstitution of leukemia in xenografts. (PubMed id 22094587)1 Fuka G....Panzer-GrA1mayer R. (Leukemia 2012)
    458. Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus. (PubMed id 23092893)1 Liu Y....Nimer S.D. (Sci Signal 2012)
    459. Redox modification of Akt mediated by the dopaminergic neurotoxin MPTP, in mouse midbrain, leads to down-regulation of pAkt. (PubMed id 22198382)1 Durgadoss L....Ravindranath V. (FASEB J. 2012)
    460. [Molecular mechanism of erlotinib resistance in epidermal growth factor receptor mutant non-small cell lung cancer cell line H1650]. (PubMed id 23249714)1 Han R....Zhang J. (Zhongguo Fei Ai Za Zhi 2012)
    461. Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells. (PubMed id 22185283)1 Cheng Z....Pan L. (amp 2012)
    462. Cytoplasmic Skp2 expression is associated with p-Akt1 and predicts poor prognosis in human breast carcinomas. (PubMed id 23300741)1 Liu J....Zhang G.J. (PLoS ONE 2012)
    463. Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: a pattern distinct from other sarcomas with complex genomics. (PubMed id 22648906)1 Italiano A....Antonescu C.R. (Cancer 2012)
    464. Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis. (PubMed id 22768179)1 Hussain A.R....Uddin S. (PLoS ONE 2012)
    465. Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1. (PubMed id 22619175)1 Collak F.K....Cinar B. (J. Biol. Chem. 2012)
    466. Marked reduction of AKT1 expression and deregulation of AKT1-associated pathways in peripheral blood mononuclear cells of schizophrenia patients. (PubMed id 22393424)1 van Beveren N.J....Elgersma Y. (PLoS ONE 2012)
    467. Transforming growth factor-I^1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways. (PubMed id 21713404)1 Chen X.F....Wang H.Y. (Mol. Biol. Rep. 2012)
    468. AKT signaling pathway activated by HIN-1 methylation in non-small cell lung cancer. (PubMed id 22095135)1 Yu Y....Guo M. (Tumour Biol. 2012)
    469. CD133 negatively regulates tumorigenicity via AKT pathway in synovial sarcoma. (PubMed id 22571340)1 Kimura T....Tanaka S. (Cancer Invest. 2012)
    470. The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY. (PubMed id 22315412)1 Ezell S.A....Tsichlis P.N. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    471. Erufosine suppresses breast cancer in vitro and in vivo for its activity on PI3K, c-Raf and Akt proteins. (PubMed id 22752602)1 Dineva I.K....Berger M.R. (J. Cancer Res. Clin. Oncol. 2012)
    472. EGCG inhibits Tat-induced LTR transactivation: role of Nrf2, AKT, AMPK signaling pathway. (PubMed id 22480519)1 Zhang H.S....Ruan Z. (Life Sci. 2012)
    473. Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation. (PubMed id 22740686)1 Patsoukis N....Boussiotis V.A. (Sci Signal 2012)
    474. Cyr61 induces IL-6 production by fibroblast-like synoviocytes promoting Th17 differentiation in rheumatoid arthritis. (PubMed id 22547695)1 Lin J....Li N. (J. Immunol. 2012)
    475. miR-122 regulates p53/Akt signalling and the chemotherapy-induced apoptosis in cutaneous T-cell lymphoma. (PubMed id 22235305)1 ManfA" V....Gniadecki R. (PLoS ONE 2012)
    476. Differential function of Akt1 and Akt2 in human adipocytes. (PubMed id 22480544)1 Fischer-Posovszky P....Wabitsch M. (Mol. Cell. Endocrinol. 2012)
    477. Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells. (PubMed id 22117074)1 Nunes-Xavier C.E....Pulido R. (J. Biol. Chem. 2012)
    478. Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab. (PubMed id 22842582)1 Grell P....Svoboda M. (Int. J. Oncol. 2012)
    479. FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer. (PubMed id 22590527)1 Hou J. and Wang L. (PLoS ONE 2012)
    480. Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts. (PubMed id 22607554)1 Storozhuk Y....Tsakiridis T. (Radiat Oncol 2012)
    481. A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma. (PubMed id 23107319)1 Korkolopoulou P....Saetta A.A. (BJU Int. 2012)
    482. SPARC overexpression inhibits cell proliferation in neuroblastoma and is partly mediated by tumor suppressor protein PTEN and AKT. (PubMed id 22567126)1 Bhoopathi P....Rao J.S. (PLoS ONE 2012)
    483. AKT1 loss correlates with episomal HPV16 in vulval intraepithelial neoplasia. (PubMed id 22685591)1 Ekeowa-Anderson A.L....O'Shaughnessy R.F. (PLoS ONE 2012)
    484. An ATP-site on-off switch that restricts phosphatase accessibility of Akt. (PubMed id 22569334)1 Lin K....Brandhuber B.J. (Sci Signal 2012)
    485. CXCR7 mediated GiI+ independent activation of ERK and Akt promotes cell survival and chemotaxis in T cells. (PubMed id 22070874)1 Kumar R....Luthra K. (Cell. Immunol. 2012)
    486. 18I^-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells. (PubMed id 21732363)1 Sharma G....Das P.K. (J. Cell. Physiol. 2012)
    487. XB130 mediates cancer cell proliferation and survival through multiple signaling events downstream of Akt. (PubMed id 22928011)1 Shiozaki A....Liu M. (PLoS ONE 2012)
    488. Distinct roles of AKT isoforms in regulating I^1-integrin activity, migration, and invasion in prostate cancer. (PubMed id 22809628)1 Virtakoivu R....Ivaska J. (Mol. Biol. Cell 2012)
    489. Increased activation of the PI3K/AKT pathway compromises decidualization of stromal cells from endometriosis. (PubMed id 22072736)1 Yin X....Kim J.J. (J. Clin. Endocrinol. Metab. 2012)
    490. Modulation of AKT activity is associated with reversible dormancy in ascites-derived epithelial ovarian cancer spheroids. (PubMed id 22045027)1 Correa R.J....Shepherd T.G. (Carcinogenesis 2012)
    491. Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes. (PubMed id 22146979)1 Wang L.E....Mills G.B. (J. Cancer Res. Clin. Oncol. 2012)
    492. The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas. (PubMed id 21874010)1 Lee D....Kim D.S. (Mod. Pathol. 2012)
    493. Expression of pERK and pAKT in pediatric high grade astrocytomas: correlation with YKL40 and prognostic significance. (PubMed id 21978279)1 Antonelli M....Giangaspero F. (Neuropathology 2012)
    494. Activation of Akt is associated with poor prognosis and chemotherapeutic resistance in pediatric B-precursor acute lymphoblastic leukemia. (PubMed id 22183914)1 Morishita N....Morishima T. (amp 2012)
    495. Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck. (PubMed id 23046567)1 Stegeman H....Bussink J. (BMC Cancer 2012)
    496. RNA interference of PARG could inhibit the metastatic potency of colon carcinoma cells via PI3-kinase/Akt pathway. (PubMed id 22508044)1 Li Q....Lazar A. (Cell. Physiol. Biochem. 2012)
    497. EGFR and downstream genetic alterations in KRAS/BRAF and PI3K/AKT pathways in colorectal cancer: implications for targeted therapy. (PubMed id 23021375)1 Berg M. and Soreide K. (Discov Med 2012)
    498. Src, Akt, NF-I_B, BCL-2 and c-IAP1 may be involved in an anti-apoptotic effect in patients with BCR-ABL positive and BCR-ABL negative acute lymphoblastic leukemia. (PubMed id 22591684)1 VA!zquez-Franco J.E....Lezama R.A. (Leuk. Res. 2012)
    499. AKT1 polymorphisms and survival of early stage non-small cell lung cancer. (PubMed id 21842521)1 Kim M.J....Park J.Y. (J Surg Oncol 2012)
    500. Akt activation is responsible for enhanced migratory and invasive behavior of arsenic-transformed human bronchial epithelial cells. (PubMed id 21954225)1 Wang Z....Yang C. (Environ. Health Perspect. 2012)
    501. Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development. (PubMed id 22391209)1 Caracciolo V....Giordano A. (Cell Cycle 2012)
    502. Insulin fails to enhance mTOR phosphorylation, mitochondrial protein synthesis, and ATP production in human skeletal muscle without amino acid replacement. (PubMed id 22967500)1 Barazzoni R....Nair K.S. (Am. J. Physiol. Endocrinol. Metab. 2012)
    503. GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. (PubMed id 22384056)1 Lin J.E....Waldman S.A. (PLoS ONE 2012)
    504. Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation. (PubMed id 22366458)1 Chung J.... Chung I.K. (J. Cell Sci. 2012)
    505. Differential effects of AKT1(p.E17K) expression on human mammary luminal epithelial and myoepithelial cells. (PubMed id 22505016)1 Salhia B....Carpten J. (Hum. Mutat. 2012)
    506. Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways. (PubMed id 22213475)1 Chen Q....Li W. (Hepatology 2012)
    507. Genomic complexity and AKT dependence in serous ovarian cancer. (PubMed id 22328975)1 Hanrahan A.J....Solit D.B. (Cancer Discov 2012)
    508. The miRNA-17a8192 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. (PubMed id 22116552)1 Rao E....Fu K. (Leukemia 2012)
    509. Requirement of transmembrane domain for CD154 association to lipid rafts and subsequent biological events. (PubMed id 22905203)1 Benslimane N....Mourad W. (PLoS ONE 2012)
    510. Heat Shock Protein 90 is overexpressed in high-risk myelodysplastic syndromes and associated with higher expression and activation of Focal Adhesion Kinase. (PubMed id 23047954)1 Flandrin-Gresta P....Campos L. (Oncotarget 2012)
    511. Genetic overlap between schizophrenia and bipolar disorder: a study with AKT1 gene variants and clinical phenotypes. (PubMed id 22277669)1 Karege F....SchA1rhoff F. (Schizophr. Res. 2012)
    512. RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells. (PubMed id 22231444)1 Lin F.C....Lu P.J. (Oncogene 2012)
    513. CYLD negatively regulates transforming growth factor-I^-signalling via deubiquitinating Akt. (PubMed id 22491319)1 Lim J.H....Li J.D. (Nat Commun 2012)
    514. The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus. (PubMed id 22727668)1 Zhou Z....Fu X.D. (Mol. Cell 2012)
    515. CaM kinase control of AKT and LNCaP cell survival. (PubMed id 22173970)1 Schmitt J.M....Fletcher L. (J. Cell. Biochem. 2012)
    516. Proximity ligation assays for isoform-specific Akt activation in breast cancer identify activated Akt1 as a driver of progression. (PubMed id 22430898)1 Spears M....Bartlett J.M. (J. Pathol. 2012)
    517. PTEN-mediated AKT activation contributes to the reduced apoptosis among Indian oral squamous cell carcinoma patients. (PubMed id 22033727)1 Alyasiri N.S....Rizvi M.M. (J. Cancer Res. Clin. Oncol. 2012)
    518. CXCL8 enhances proliferation and growth and reduces apoptosis in endometrial stromal cells in an autocrine manner via a CXCR1-triggered PTEN/AKT signal pathway. (PubMed id 22563025)1 Li M.Q....Li D.J. (Hum. Reprod. 2012)
    519. Long isoform of ErbB3 binding protein, p48, mediates protein kinase B/Akt-dependent HDM2 stabilization and nuclear localization. (PubMed id 21930127)1 Kim C.K....Ahn J.Y. (Exp. Cell Res. 2012)
    520. Diverse regulation of AKT and GSK-3I^ by O-GlcNAcylation in various types of cells. (PubMed id 22687243)1 Shi J....Gong C.X. (FEBS Lett. 2012)
    521. Protein kinase G and focal adhesion kinase converge on Src/Akt/I^-catenin signaling module in osteoblast mechanotransduction. (PubMed id 22563076)1 Rangaswami H....Pilz R.B. (J. Biol. Chem. 2012)
    522. [Expression and significance of p-AKT, p-GSK3I^ and I^-catenin in epithelial carcinoma of ovary]. (PubMed id 22455883)1 Wei X....Cao C.C. (Zhonghua Bing Li Xue Za Zhi 2012)
    523. Receptor-specific mechanisms regulate phosphorylation of AKT at Ser473: role of RICTOR in I^1 integrin-mediated cell survival. (PubMed id 22384145)1 Riaz A....Johansson S. (PLoS ONE 2012)
    524. Alteration in methylation pattern of oncogene Akt1 promoter region in bladder cancer. (PubMed id 22189542)1 Sun X.F....Shen W. (Mol. Biol. Rep. 2012)
    525. Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. (PubMed id 23112296)1 Wang R.C....Levine B. (Science 2012)
    526. NAMPT (visfatin) and AKT1 genetic variants associate with myocardial infarction. (PubMed id 22251423)1 Leander K....HAPgberg J. ( international journal of clinical chemistry 2012)
    527. Promotion of the induction of cell pluripotency through metabolic remodeling by thyroid hormone triiodothyronine-activated PI3K/AKT signal pathway. (PubMed id 22575839)1 Chen M....Li T. (Biomaterials 2012)
    528. Epstein-Barr virus latent membrane protein-1 protects B-cell lymphoma from rituximab-induced apoptosis through miR-155-mediated Akt activation and up-regulation of Mcl-1. (PubMed id 22268450)1 Kim J.H....Park C. (amp 2012)
    529. Mutations in FGFR3 and PIK3CA, singly or combined with RAS and AKT1, are associated with AKT but not with MAPK pathway activation in urothelial bladder cancer. (PubMed id 22417847)1 Juanpere N....HernA!ndez S. (Hum. Pathol. 2012)
    530. Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users. (PubMed id 22831980)1 Di Forti M....Murray R.M. (Biol. Psychiatry 2012)
    531. Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers. (PubMed id 23134728)1 Parikh C....Seshagiri S. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    532. Identification of Akt interaction protein PHF20/TZP that transcriptionally regulates p53. (PubMed id 22334668)1 Park S....Cheng J.Q. (J. Biol. Chem. 2012)
    533. Genetic variants in the PI3K/PTEN/AKT/mTOR pathway predict platinum-based chemotherapy response of advanced non-small cell lung cancers in a Chinese population. (PubMed id 22901187)1 Xu J.L....Shu Y.Q. (Asian Pac. J. Cancer Prev. 2012)
    534. Transient activation of the PI3K-AKT pathway by hepatitis C virus to enhance viral entry. (PubMed id 23095753)1 Liu Z....Ou J.H. (J. Biol. Chem. 2012)
    535. Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression. (PubMed id 22271581)1 Wen W....Wang H. (Hepatology 2012)
    536. Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway. (PubMed id 22301279)1 Kong L....Klocker H. (Carcinogenesis 2012)
    537. Differential expression of gastric MUC5AC in colonic epithelial cells: TFF3-wired IL1 I^/Akt crosstalk-induced mucosal immune response against Shigella dysenteriae infection. (PubMed id 22389405)1 Raja S.B....Devaraj S.N. (J. Cell. Sci. 2012)
    538. Loss of Akt1 evokes epithelial-mesenchymal transition by autocrine regulation of transforming growth factor-I^1. (PubMed id 21925532)1 Kim E.K....Bae S.S. (Adv Biol Regul 2012)
    539. Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires I^-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways. (PubMed id 22270359)1 Yan D....Sharma D. (J. Biol. Chem. 2012)
    540. Role of PRAS40 in Akt and mTOR signaling in health and disease. (PubMed id 22354785)1 Wiza C....Ouwens D.M. (Am. J. Physiol. Endocrinol. Metab. 2012)
    541. Difference in expression of EGFR, pAkt, and PTEN between oropharyngeal and oral cavity squamous cell carcinoma. (PubMed id 22682934)1 Won H.S....Kim M.S. (Oral Oncol. 2012)
    542. The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas. (PubMed id 21837670)1 Setsu N....Oda Y. (Cancer 2012)
    543. Growth inhibitory effect of dihydroartemisinin on Bcr/Abl+ chronic myeloid leukemia K562 cells involve AKT, ERK and NF-I_B modulation. (PubMed id 22833150)1 Lee J....Zhang X. (J. Cancer Res. Clin. Oncol. 2012)
    544. Altered AKT1 and MAPK1 gene expression on peripheral blood mononuclear cells and correlation with T-helper-transcription factors in systemic lupus erythematosus patients. (PubMed id 23125486)1 Garcia-Rodriguez S....Zubiaur M. (Mediators Inflamm. 2012)
    545. Activation of AKT is associated with metastasis of nasopharyngeal carcinoma. (PubMed id 22116667)1 Liu Y....Guan J. (Tumour Biol. 2012)
    546. USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-I^ type I receptor. (PubMed id 22706160)1 Zhang L....ten Dijke P. (Nat. Cell Biol. 2012)
    547. Targeting PI3 kinase/AKT/mTOR signaling in cancer. (PubMed id 22471665)1 Sheppard K....Phillips W.A. (Crit Rev Oncog 2012)
    548. Hyperphosphorylation of Tau induced by naturally secreted amyloid-I^ at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3I^ signaling pathway. (PubMed id 22910909)1 Tokutake T....Ikeuchi T. (J. Biol. Chem. 2012)
    549. Phospho-Akt immunoreactivity in prostate cancer: relationship to disease severity and outcome, Ki67 and phosphorylated EGFR expression. (PubMed id 23133535)1 Hammarsten P....Fowler C.J. (PLoS ONE 2012)
    550. Epistatic interactions of AKT1 on human medial temporal lobe biology and pharmacogenetic implications. (PubMed id 21788944)1 Tan H.Y....Weinberger D.R. (Mol. Psychiatry 2012)
    551. Increased apoptosis in human knee osteoarthritis cartilage related to the expression of protein kinase B and protein kinase C&amp;#945; in chondrocytes. (PubMed id 22532149)1 Chen Q....Xia C. (Folia Histochem. Cytobiol. 2012)
    552. Akt augments the oncogenic potential of the HBx protein of hepatitis B virus by phosphorylation. (PubMed id 22309289)1 Khattar E....Kumar V. (FEBS J. 2012)
    553. Endothelial derived factors inhibit anoikis of head and neck cancer stem cells. (PubMed id 22014666)1 Campos M.S....NAPr J.E. (Oral Oncol. 2012)
    554. USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells. (PubMed id 22426999)1 Zhiqiang Z....Yuepeng G. (J. Cancer Res. Clin. Oncol. 2012)
    555. A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling. (PubMed id 22895078)1 Liu L....Jove R. (amp 2012)
    556. Notch1 activation promotes renal cell carcinoma growth via PI3K/Akt signaling. (PubMed id 22463491)1 Xu L....Lin Z. (Cancer Sci. 2012)
    557. CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor I_B: implications for bidirectional tumor-stromal interactions. (PubMed id 22995914)1 Singh A.P....Singh S. (J. Biol. Chem. 2012)
    558. The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition. (PubMed id 22345097)1 Li B....Sun S.Y. (Cancer Prev Res (Phila) 2012)
    559. Regulation of inflammatory breast cancer cell invasion through Akt1/PKBI+ phosphorylation of RhoC GTPase. (PubMed id 22896661)1 Lehman H.L....van Golen K.L. (Mol. Cancer Res. 2012)
    560. A phytoestrogen diarylheptanoid mediates estrogen receptor/Akt/glycogen synthase kinase 3I^ protein-dependent activation of the Wnt/I^-catenin signaling pathway. (PubMed id 22936801)1 Bhukhai K....Chairoungdua A. (J. Biol. Chem. 2012)
    561. AKT-mediated regulation of polarization in differentiated human neutrophil-like HL-60 cells. (PubMed id 22588279)1 Zou W....Zou F. (Inflamm. Res. 2012)
    562. Exogenous and autocrine growth factors stimulate human intervertebral disc cell proliferation via the ERK and Akt pathways. (PubMed id 22105580)1 Pratsinis H....Kletsas D. (J. Orthop. Res. 2012)
    563. Akt- and Erk-mediated regulation of proliferation and differentiation during PDGFRI^-induced MSC self-renewal. (PubMed id 22805337)1 Gharibi B....Hughes F.J. (J. Cell. Mol. Med. 2012)
    564. PHF19 and Akt control the switch between proliferative and invasive states in melanoma. (PubMed id 22487681)1 Ghislin S....Alcaide-Loridan C. (Cell Cycle 2012)
    565. PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity. (PubMed id 22375056)1 Tibarewal P....Leslie N.R. (Sci Signal 2012)
    566. Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells. (PubMed id 22335196)1 Wang J....Deng W. (J. Pineal Res. 2012)
    567. LEDGF gene silencing impairs the tumorigenicity of prostate cancer DU145 cells by abating the expression of Hsp27 and activation of the Akt/ERK signaling pathway. (PubMed id 22647853)1 Bhargavan B....Singh D.P. (amp 2012)
    568. Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway. (PubMed id 22875023)1 Ramaswamy B....Majumder S. (Cancer Res. 2012)
    569. The role of Akt signalling in the mammalian ovary. (PubMed id 23417403)1 Cecconi S....Patacchiola F. (Int. J. Dev. Biol. 2012)
    570. 14-3-3I8 regulation by p53 mediates a chemotherapy response to 5-fluorouracil in MCF-7 breast cancer cells via Akt inactivation. (PubMed id 22192357)1 Zheng G....He Z. (FEBS Lett. 2012)
    571. Activation of the PI3K/AKT pathway in Merkel cell carcinoma. (PubMed id 22363598)1 Hafner C....Becker J.C. (PLoS ONE 2012)
    572. Effective connectivity of AKT1-mediated dopaminergic working memory networks and pharmacogenetics of anti-dopaminergic treatment. (PubMed id 22525159)1 Tan H.Y....Weinberger D.R. (Brain 2012)
    573. Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein. (PubMed id 22084251)1 Glidden E.J....Mayo M.W. (J. Biol. Chem. 2012)
    574. Overexpression of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) in HepG2 cells leads to increased hyaluronan synthesis and cell proliferation by up-regulation of cyclin D1 in AKT-dependent pathway. (PubMed id 22451658)1 Kaul R....Datta K. (J. Biol. Chem. 2012)
    575. RGD-peptide lunasin inhibits Akt-mediated NF-I_B activation in human macrophages through interaction with the I+VI^3 integrin. (PubMed id 22945510)1 Cam A. and de Mejia E.G. (amp 2012)
    576. Synemin promotes AKT-dependent glioblastoma cell proliferation by antagonizing PP2A. (PubMed id 22337773)1 Pitre A....Skalli O. (Mol. Biol. Cell 2012)
    577. Involvement of Akt/NF-I_B pathway in antitumor effects of parthenolide on glioblastoma cells in vitro and in vivo. (PubMed id 23039130)1 Nakabayashi H. and Shimizu K. (BMC Cancer 2012)
    578. Integrin I+5I^1 simultaneously controls EGFR-dependent proliferation and Akt-dependent pro-survival signaling in epidermoid carcinoma cells. (PubMed id 22626691)1 Morozevich G.E....Berman A.E. (Aging (Albany NY) 2012)
    579. Akt phosphorylation in human chondrocytes is regulated by p53R2 in response to mechanical stress. (PubMed id 22954457)1 Kawakita K....Kurosaka M. (Osteoarthr. Cartil. 2012)
    580. Notch1 promotes glioma cell migration and invasion by stimulating I^-catenin and NF-I_B signaling via AKT activation. (PubMed id 22093097)1 Zhang X....Ge J. (Cancer Sci. 2012)
    581. IL-22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade. (PubMed id 22840496)1 Mitra A....Raychaudhuri S.P. (Cytokine 2012)
    582. HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2. (PubMed id 22904195)1 Caccuri F....Caruso A. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    583. CD40 stimulation induces vincristine resistance via AKT activation and MRP1 expression in a human multiple myeloma cell line. (PubMed id 22445357)1 Lee S.W....Choi I. (Immunol. Lett. 2012)
    584. Fascin, a novel marker of human hepatic stellate cells, may regulate their proliferation, migration, and collagen gene expression through the FAK-PI3K-Akt pathway. (PubMed id 22005766)1 Uyama N....Fujimoto J. ( a journal of technical methods and pathology 2012)
    585. Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells. (PubMed id 22285928)1 Yang C....Chen W. (Gene 2012)
    586. Genetic variations in a PTEN/AKT/mTOR axis and prostate cancer risk in a Chinese population. (PubMed id 22815832)1 Chen J....Yin C. (PLoS ONE 2012)
    587. A conserved role of IQGAP1 in regulating TOR complex 1. (PubMed id 22328503)1 Tekletsadik Y.K....Osman M.A. (J. Cell. Sci. 2012)
    588. Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2. (PubMed id 22394561)1 Worster D.T....Albeck J.G. (Sci Signal 2012)
    589. PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells. (PubMed id 22031597)1 Ogawa A....Yuan J.X. (Am. J. Physiol., Cell Physiol. 2012)
    590. Grape proanthocyanidin inhibit pancreatic cancer cell growth in vitro and in vivo through induction of apoptosis and by targeting the PI3K/Akt pathway. (PubMed id 22905202)1 Prasad R....Katiyar S.K. (PLoS ONE 2012)
    591. Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function. (PubMed id 21049487)1 Balu D.T....Lucki I. (Hippocampus 2012)
    592. Hepatocyte growth factor increases osteopontin expression in human osteoblasts through PI3K, Akt, c-Src, and AP-1 signaling pathway. (PubMed id 22675553)1 Chen H.T....Tang C.H. (PLoS ONE 2012)
    593. Autophagy limits the cytotoxic effects of the AKT inhibitor AZ7328 in human bladder cancer cells. (PubMed id 22895070)1 Dickstein R.J....McConkey D.J. (amp 2012)
    594. Mucinous breast carcinomas lack PIK3CA and AKT1 mutations. (PubMed id 22705004)1 Kehr E.L....Troxell M.L. (Hum. Pathol. 2012)
    595. MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma. (PubMed id 22234835)1 Fang Y....Tian L. (Hepatology 2012)
    596. Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells. (PubMed id 23041284)1 Lin Y....Wang Y.J. (Mol. Cell 2012)
    597. Integrin I^1 mediates vaccinia virus entry through activation of PI3K/Akt signaling. (PubMed id 22496232)1 Izmailyan R....Chang W. (J. Virol. 2012)
    598. Akt and phospholipase CI^ are involved in the regulation of growth and migration of MDA-MB-468 breast cancer and SW480 colon cancer cells when cultured with diabetogenic levels of glucose and insulin. (PubMed id 22554284)1 Tomas N.M....ZAonker K.S. (BMC Res Notes 2012)
    599. HT-29 human colon cancer cell proliferation is regulated by cytosolic phospholipase A(2)I+ dependent PGE(2)via both PKA and PKB pathways. (PubMed id 22728329)1 Kisslov L....Levy R. (Biochim. Biophys. Acta 2012)
    600. EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex. (PubMed id 22314363)1 Li G....Xie D. (Nat Commun 2012)
    601. Involvement of microRNA-93, a new regulator of PTEN/Akt signaling pathway, in regulation of chemotherapeutic drug cisplatin chemosensitivity in ovarian cancer cells. (PubMed id 22465665)1 Fu X....Hao Q. (FEBS Lett. 2012)
    602. Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells. (PubMed id 23167739)1 Grabinski N....JA1cker M. (Mol. Cancer 2012)
    603. Expression of podoplanin in human astrocytic brain tumors is controlled by the PI3K-AKT-AP-1 signaling pathway and promoter methylation. (PubMed id 22394497)1 Peterziel H....Angel P. (Neuro-oncology 2012)
    604. Selective modulation of subtype III IPa88R by Akt regulates ER CaA^a8_ release and apoptosis. (PubMed id 22552281)1 Marchi S....Pinton P. (amp 2012)
    605. Protein kinase B phosphorylation correlates with vascular endothelial growth factor A and microvessel density in gastric adenocarcinoma. (PubMed id 23321169)1 Zhou X.D....Lv N.H. (J. Int. Med. Res. 2012)
    606. Activation of protein kinase B/Akt by alpha1-adrenoceptors in the human prostate. (PubMed id 22280833)1 Strittmatter F....Hennenberg M. (Life Sci. 2012)
    607. Activation of GABA(B) receptors inhibits protein kinase B/glycogen synthase kinase 3 signaling. (PubMed id 23192081)1 Lu F.F....Daskalakis Z.J. (Mol Brain 2012)
    608. Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation. (PubMed id 22957045)1 Ridnour L.A....Wink D.A. (PLoS ONE 2012)
    609. GATA2 negatively regulates PTEN by preventing nuclear translocation of androgen receptor and by androgen-independent suppression of PTEN transcription in breast cancer. (PubMed id 22021428)1 Wang Y....Eng C. (Hum. Mol. Genet. 2012)
    610. Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt. (PubMed id 23176396)1 Kuo S.Z....Ongkeko W.M. (BMC Cancer 2012)
    611. Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer. (PubMed id 23236232)1 Sukawa Y....Shinomura Y. (World J. Gastroenterol. 2012)
    612. Phosphorylated AKT protein is overexpressed in human peripheral T-cell lymphomas and predicts decreased patient survival. (PubMed id 22297255)1 Cai Q....Lin T. (amp 2012)
    613. Epstein-Barr virus latent membrane protein-2A induces ITAM/Syk- and Akt-dependent epithelial migration through I+v-integrin membrane translocation. (PubMed id 22837212)1 Fotheringham J.A....Raab-Traub N. (J. Virol. 2012)
    614. Knockdown of c-Met enhances sensitivity to bortezomib in human multiple myeloma U266 cells via inhibiting Akt/mTOR activity. (PubMed id 22339676)1 Que W....Jiang D. (APMIS 2012)
    615. Pathobiological implications of the expression of EGFR, pAkt, NF-I_B and MIC-1 in prostate cancer stem cells and their progenies. (PubMed id 22384099)1 Mimeault M....Batra S.K. (PLoS ONE 2012)
    616. Signaling networks associated with AKT activation in non-small cell lung cancer (NSCLC): new insights on the role of phosphatydil-inositol-3 kinase. (PubMed id 22363436)1 Scrima M....Viglietto G. (PLoS ONE 2012)
    617. Sp1 is involved in regulation of cystathionine I^-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular carcinoma cell lines. (PubMed id 22360859)1 Yin P....Zha X. (Cell. Signal. 2012)
    618. Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. (PubMed id 22569400)1 Negro R....Efremov D.G. (Blood 2012)
    619. Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model. (PubMed id 22952709)1 Loganathan S....Srivastava S.K. (PLoS ONE 2012)
    620. BMP signalling controls the malignant potential of ascites-derived human epithelial ovarian cancer spheroids via AKT kinase activation. (PubMed id 22249415)1 Peart T.M....Shepherd T.G. (amp 2012)
    621. VE-cadherin trans-interactions modulate Rac activation and enhancement of lung endothelial barrier by iloprost. (PubMed id 22213015)1 Birukova A.A....Birukov K.G. (J. Cell. Physiol. 2012)
    622. Akt, FoxO and regulation of apoptosis. (PubMed id 21440011)1 Zhang X....Rishi A.K. (Biochim. Biophys. Acta 2011)
    623. Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons. (PubMed id 20838929)1 Currais A....Soriano S. (J. Mol. Neurosci. 2011)
    624. Akt/protein B and estradiol receptor alpha expressions in postmenopausal endometrium. (PubMed id 21295396)1 Wilhelm F....SzabA^ I. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2011)
    625. Nuclear translocation of epidermal growth factor receptor by Akt- dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells. (PubMed id 21487020)1 Huang W.C.... Hung M.C. (J. Biol. Chem. 2011)
    626. Spatial relationship of phosphorylated epidermal growth factor receptor and activated AKT in head and neck squamous cell carcinoma. (PubMed id 21775008)1 Nijkamp M.M....Kaanders J.H. (Radiother Oncol 2011)
    627. PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains. (PubMed id 21873248)1 Gao X....Zhang J. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    628. Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway. (PubMed id 21680733)1 Imanishi Y....Cheng S.Y. (J. Biol. Chem. 2011)
    629. Activation of Akt/GSK3I^ and Akt/Bcl-2 signaling pathways in nickel-transformed BEAS-2B cells. (PubMed id 21837363)1 Pan J.J....Shi X. (Int. J. Oncol. 2011)
    630. Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt. (PubMed id 21701506)1 Li X....Gao T. (EMBO Rep. 2011)
    631. Akt phosphorylates and regulates the osteogenic activity of Osterix. (PubMed id 21777568)1 Choi Y.H....Lee K.Y. (Biochem. Biophys. Res. Commun. 2011)
    632. Myotubularin regulates Akt-dependent survival signaling via phosphatidylinositol 3-phosphate. (PubMed id 21478156)1 Razidlo G.L....Taylor G.S. (J. Biol. Chem. 2011)
    633. Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration. (PubMed id 21437936)1 Kim S.R....Burke R.E. (Ann. Neurol. 2011)
    634. The PKB/FOXO switch in aging and cancer. (PubMed id 21539865)1 Kloet D.E. and Burgering B.M. (Biochim. Biophys. Acta 2011)
    635. Hepatocyte growth factor inhibits anoikis of pancreatic carcinoma cells through phosphatidylinositol 3-kinase pathway. (PubMed id 21499215)1 Watanabe S....Yokosuka O. (Pancreas 2011)
    636. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    637. Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat. (PubMed id 21765914)1 Kim Y....Kim B. (PLoS ONE 2011)
    638. Calcium-induced apoptosis is delayed by HER1 receptor signalling through the Akt and PLCI^ pathways in bladder cancer cells. (PubMed id 21087080)1 Memon A.A....Sorensen B.S. (Scand. J. Clin. Lab. Invest. 2011)
    639. The phosphatidylinositol 3' kinase-Akt-mammalian target of rapamycin pathway in smooth muscle tumors of the uterus: selected protein expression patterns and their clinicopathologic implications. (PubMed id 21464729)1 Fadare O....Liang S.X. (Int. J. Gynecol. Pathol. 2011)
    640. Chemokine CXCL12 uses CXCR4 and a signaling core formed by bifunctional Akt, extracellular signal-regulated kinase (ERK)1/2, and mammalian target of rapamycin complex 1 (mTORC1) proteins to control chemotaxis and survival simultaneously in mature dendritic cells. (PubMed id 21878648)1 Delgado-MartA-n C....RodrA-guez-FernA!ndez J.L. (J. Biol. Chem. 2011)
    641. DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance. (PubMed id 22131882)1 Stronach E.A....Gabra H. (Neoplasia 2011)
    642. Co-administration of perifosine with paclitaxel synergistically induces apoptosis in ovarian cancer cells: more than just AKT inhibition. (PubMed id 21775054)1 Sun H....Li J. (Cancer Lett. 2011)
    643. Mislocalization of the E3 ligase, I^-transducin repeat-containing protein 1 (I^-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt. (PubMed id 21454620)1 Warfel N.A....Newton A.C. (J. Biol. Chem. 2011)
    644. Mild stretch activates cPLA2 in alveolar type II epithelial cells independently through the MEK/ERK and PI3K pathways. (PubMed id 21185392)1 Letsiou E....Lekka M.E. (Biochim. Biophys. Acta 2011)
    645. Genetic polymorphisms in inflammation pathway genes and prostate cancer risk. (PubMed id 21430300)1 Kwon E.M....Ostrander E.A. (amp 2011)
    646. Targeting the Akt/mTOR pathway in Brca1-deficient cancers. (PubMed id 21242970)1 Xiang T....Yang Q. (Oncogene 2011)
    647. The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization. (PubMed id 21127195)1 Wang Y....Marx S.J. (Cancer Res. 2011)
    648. Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity. (PubMed id 22031698)1 Chan T.O....Feldman A.M. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    649. The vanilloid capsaicin induces IL-6 secretion in prostate PC-3 cancer cells. (PubMed id 21474332)1 Malagarie-Cazenave S....DA-az-Laviada I. (Cytokine 2011)
    650. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    651. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    652. Downregulation of uPAR inhibits migration, invasion, proliferation, FAK/PI3K/Akt signaling and induces senescence in papillary thyroid carcinoma cells. (PubMed id 21191179)1 Nowicki T.S....Geliebter J. (Cell Cycle 2011)
    653. Ghrelin inhibits AGEs-induced apoptosis in human endothelial cells involving ERK1/2 and PI3K/Akt pathways. (PubMed id 21370247)1 Xiang Y....Zhang J. (Cell Biochem. Funct. 2011)
    654. Regulation of FoxO transcription factors by acetylation and protein-protein interactions. (PubMed id 21396404)1 Daitoku H....Fukamizu A. (Biochim. Biophys. Acta 2011)
    655. Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation. (PubMed id 21890492)1 Sharma L.K....Bai Y. (Hum. Mol. Genet. 2011)
    656. Overexpression of MUC1 enhances proangiogenic activity of non-small-cell lung cancer cells through activation of Akt and extracellular signal-regulated kinase pathways. (PubMed id 21959954)1 Yao M....Cui B. (Lung 2011)
    657. mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected]. (PubMed id 21592956)1 Moore S.F....Hers I. (J. Biol. Chem. 2011)
    658. Overexpression of CREG attenuates atherosclerotic endothelium apoptosis via VEGF/PI3K/AKT pathway. (PubMed id 21872252)1 Wang N....Yan C. (Atherosclerosis 2011)
    659. Gq protein-induced apoptosis is mediated by AKT kinase inhibition that leads to protein kinase C-induced c-Jun N-terminal kinase activation. (PubMed id 21757743)1 Ben-Ami I....Seger R. (J. Biol. Chem. 2011)
    660. Akt cross-links IL-4 priming, stem cell factor signaling, and IgE-dependent activation in mature human mast cells. (PubMed id 21106245)1 Feuser K....Lorentz A. (Mol. Immunol. 2011)
    661. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    662. Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2. (PubMed id 21908613)1 Warfel N.A....Newton A.C. (J. Biol. Chem. 2011)
    663. Human immunodeficiency virus type 1 induces lytic cycle replication of Kaposi's-sarcoma-associated herpesvirus: role of Ras/c-Raf/MEK1/2, PI3K/AKT, and NF-I_B signaling pathways. (PubMed id 21763505)1 Zhu X....Lu C. (J. Mol. Biol. 2011)
    664. Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling. (PubMed id 21131356)1 Tato I....Rosa J.L. (J. Biol. Chem. 2011)
    665. AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: role of AIP4/Itch-mediated JUNB degradation. (PubMed id 21135252)1 Vartanian R....Gera J. (Mol. Cancer Res. 2011)
    666. Phosphomimetic substitution of heterogeneous nuclear ribonucleoprotein A1 at serine 199 abolishes AKT-dependent internal ribosome entry site-transacting factor (ITAF) function via effects on strand annealing and results in mammalian target of rapamycin complex 1 (mTORC1) inhibitor sensitivity. (PubMed id 21454539)1 Martin J....Gera J. (J. Biol. Chem. 2011)
    667. Paradigm of kinase-driven pathway downstream of epidermal growth factor receptor/Akt in human lung carcinomas. (PubMed id 21040950)1 Dobashi Y....Ooi A. (Hum. Pathol. 2011)
    668. Activation of PI3 kinase/Akt signaling in chronic subdural hematoma outer membranes. (PubMed id 21309701)1 Funai M....Takayasu M. (J. Neurotrauma 2011)
    669. N-cadherin mediates angiogenesis by regulating monocyte chemoattractant protein-1 expression via PI3K/Akt signaling in prostate cancer cells. (PubMed id 21855541)1 Nalla A.K....Rao J.S. (Exp. Cell Res. 2011)
    670. Phagocytosis of melanized Aspergillus conidia by macrophages exerts cytoprotective effects by sustained PI3K/Akt signalling. (PubMed id 21501368)1 Volling K....Saluz H.P. (Cell. Microbiol. 2011)
    671. Akt isoform-specific inhibition of MDA-MB-231 cell proliferation. (PubMed id 20688159)1 Yang W....Shin I. (Cell. Signal. 2011)
    672. Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways. (PubMed id 22029423)1 Rashid A....Tsakiridis T. (Radiat Oncol 2011)
    673. Regulation of IGF-1/PI3K/Akt signalling by the phosphoinositide phosphatase pharbin. (PubMed id 21436142)1 Wang F....Takenawa T. (J. Biochem. 2011)
    674. p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1I+ pathways. (PubMed id 21254169)1 Fu J....Wang H.Y. (Hepatology 2011)
    675. Dynamic regulation of GEF-H1 localization at microtubules by Par1b/MARK2. (PubMed id 21513698)1 Yoshimura Y. and Miki H. (Biochem. Biophys. Res. Commun. 2011)
    676. Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells. (PubMed id 21405945)1 De Salvo M....Bucci B. (Int. J. Radiat. Biol. 2011)
    677. MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors. (PubMed id 21394210)1 Clegg N.J....Sawyers C.L. (PLoS ONE 2011)
    678. [Significance of phosphoinositide 3 kinase/AKT pathway alterations in endometrial carcinoma]. (PubMed id 22336203)1 Yang X....Liao Q.P. (Zhonghua Bing Li Xue Za Zhi 2011)
    679. Actin-independent exclusion of CD95 by PI3K/AKT signalling: implications for apoptosis. (PubMed id 21557211)1 Pizon M....Legembre P. (Eur. J. Immunol. 2011)
    680. p16(INK4a) suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms. (PubMed id 21390332)1 Li Y. and Tollefsbol T.O. (PLoS ONE 2011)
    681. Beta-HPV 5 and 8 E6 promote p300 degradation by blocking AKT/p300 association. (PubMed id 21901101)1 Howie H.L....Galloway D.A. (PLoS Pathog. 2011)
    682. Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN. (PubMed id 21169559)1 Tang M....Devreotes P. (Mol. Biol. Cell 2011)
    683. Asymmetric cancer cell division regulated by AKT. (PubMed id 21757645)1 Dey-Guha I....Ramaswamy S. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    684. E3 ubiquitin protein ligase, E6-associated protein (E6-AP) regulates PI3K-Akt signaling and prostate cell growth. (PubMed id 20826237)1 Srinivasan S. and Nawaz Z. (Biochim. Biophys. Acta 2011)
    685. The E-box binding factors Max/Mnt, MITF, and USF1 act coordinately with FoxO to regulate expression of proapoptotic and cell cycle control genes by phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 signaling. (PubMed id 21873430)1 Terragni J....Cooper G.M. (J. Biol. Chem. 2011)
    686. PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation. (PubMed id 20956948)1 Deng R....Zhu X.F. (Oncogene 2011)
    687. A growth factor attenuates HIV-1 Tat and morphine induced damage to human neurons: implication in HIV/AIDS-drug abuse cases. (PubMed id 21483469)1 Malik S....Seth P. (PLoS ONE 2011)
    688. Inhibition of Akt (ser473) phosphorylation and rapamycin-resistant cell growth by knockdown of mammalian target of rapamycin with small interfering RNA in vascular endothelial growth factor receptor-1-targeting vector. (PubMed id 21532145)1 Koide H....Oku N. (amp 2011)
    689. Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt, independent of the effects of EEA1. (PubMed id 21468601)1 Cheng R....Guo X.R. (Mol Med Rep 2011)
    690. mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling. (PubMed id 22140653)1 Rodrik-Outmezguine V.S....Rosen N. (Cancer Discov 2011)
    691. Valproic acid induces monoamine oxidase A via Akt/forkhead box O1 activation. (PubMed id 21775495)1 Wu J.B. and Shih J.C. (Mol. Pharmacol. 2011)
    692. Activation of I^-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters. (PubMed id 21284870)1 Li J. and Zhou B.P. (BMC Cancer 2011)
    693. Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-I_B pathways in monocytes/macrophages. (PubMed id 21742938)1 Shim Y.J....Min B.H. (J. Leukoc. Biol. 2011)
    694. AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer. (PubMed id 21878679)1 Chan J.C....Pearson R.B. (Sci Signal 2011)
    695. The mTOR/AKT inhibitor temsirolimus prevents deep infiltrating endometriosis in mice. (PubMed id 21718677)1 Leconte M....Batteux F. (Am. J. Pathol. 2011)
    696. On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN). (PubMed id 21646525)1 Numajiri N....Uehara T. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    697. AKT has an anti-apoptotic role in ABCA12-deficient keratinocytes. (PubMed id 21633372)1 Yanagi T....Shimizu H. (J. Invest. Dermatol. 2011)
    698. CNK1 and other scaffolds for Akt/FoxO signaling. (PubMed id 21320536)1 Fritz R.D. and Radziwill G. (Biochim. Biophys. Acta 2011)
    699. FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. (PubMed id 21708191)1 Tzivion G....Ramakrishnan G. (Biochim. Biophys. Acta 2011)
    700. Omentin inhibits osteoblastic differentiation of calcifying vascular smooth muscle cells through the PI3K/Akt pathway. (PubMed id 21082206)1 Duan X.Y....Tang S.Y. (Amino Acids 2011)
    701. The effect of leucine restriction on Akt/mTOR signaling in breast cancer cell lines in vitro and in vivo. (PubMed id 21294052)1 Singh G....Meric-Bernstam F. (Nutr Cancer 2011)
    702. OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling. (PubMed id 21289304)1 So T....Croft M. (J. Immunol. 2011)
    703. Angiopoietin-1/Tie2 signal augments basal Notch signal controlling vascular quiescence by inducing delta-like 4 expression through AKT-mediated activation of beta-catenin. (PubMed id 21212269)1 Zhang J....Mochizuki N. (J. Biol. Chem. 2011)
    704. [Expression and clinical significance of epidermal growth factor receptor and protein kinase B in gastric carcinoma]. (PubMed id 21365510)1 Zhang H.Y....Chen H.T. (Zhonghua Wei Chang Wai Ke Za Zhi 2011)
    705. A switch toward angiostatic gene expression impairs the angiogenic properties of endothelial progenitor cells in low birth weight preterm infants. (PubMed id 21659549)1 Ligi I....Anfosso F. (Blood 2011)
    706. ER stress inhibits mTORC2 and Akt signaling through GSK-3I^-mediated phosphorylation of rictor. (PubMed id 21343617)1 Chen C.H....Sarbassov d.o.s. .D. (Sci Signal 2011)
    707. NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox. (PubMed id 21118808)1 Edderkaoui M....Gukovskaya A.S. (J. Biol. Chem. 2011)
    708. mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif. (PubMed id 21321111)1 Wu Y.T....Su B. (J. Biol. Chem. 2011)
    709. Deciphering the signaling pathways of cancer stem cells of glioblastoma multiforme: role of Akt/mTOR and MAPK pathways. (PubMed id 21035497)1 Jhanwar-Uniyal M....Murali R. (Adv. Enzyme Regul. 2011)
    710. Tissue microarray analysis of ezrin, KBA.62, CD166, nestin, and p-Akt in melanoma versus banal and atypical nevi, and nonmelanocytic lesions. (PubMed id 21915031)1 Shanesmith R.P....Cassarino D.S. (Am J Dermatopathol 2011)
    711. A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2. (PubMed id 21177249)1 Murata H....Huh N.H. (J. Biol. Chem. 2011)
    712. ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks. (PubMed id 21263216)1 Khalil A....Valerie K. (Cell Cycle 2011)
    713. Peripheral expression of key regulatory kinases in Alzheimer's disease and Parkinson's disease. (PubMed id 20106550)1 Armentero M.T....Blandini F. (Neurobiol. Aging 2011)
    714. PI3K/Akt signaling pathway is involved in the pathogenesis of ulcerative colitis. (PubMed id 21442372)1 Huang X.L....Gan H.T. (Inflamm. Res. 2011)
    715. Campylobacter jejuni induces an anti-inflammatory response in human intestinal epithelial cells through activation of phosphatidylinositol 3-kinase/Akt pathway. (PubMed id 20863633)1 Li Y.P....Bang D.D. (Vet. Microbiol. 2011)
    716. Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively. (PubMed id 21705328)1 Chung Y.W....Chock P.B. (J. Biol. Chem. 2011)
    717. The skeleton: a multi-functional complex organ: new insights into osteoblasts and their role in bone formation: the central role of PI3Kinase. (PubMed id 21673026)1 Guntur A.R. and Rosen C.J. (J. Endocrinol. 2011)
    718. Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis. (PubMed id 21209368)1 Wang S. and Basson M.D. (Am. J. Physiol., Cell Physiol. 2011)
    719. Heat shock protein 90 maintains the tumour-like character of rheumatoid synovial cells by stabilizing integrin-linked kinase, extracellular signal-regulated kinase and protein kinase B. (PubMed id 21177334)1 Hashiramoto A....Shiozawa S. (Rheumatology (Oxford) 2011)
    720. BDNF promotes EGF-induced proliferation and migration of human fetal neural stem/progenitor cells via the PI3K/Akt pathway. (PubMed id 22146375)1 Zhang Q....Jia J. (Molecules 2011)
    721. Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins. (PubMed id 21289308)1 Yoshimi A....Kurokawa M. (Blood 2011)
    722. Akt/mTOR counteract the antitumor activities of cixutumumab, an anti-insulin-like growth factor I receptor monoclonal antibody. (PubMed id 21980128)1 Shin D.H....Lee H.Y. (Mol. Cancer Ther. 2011)
    723. Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. (PubMed id 21159778)1 Coloff J.L....Rathmell J.C. (J. Biol. Chem. 2011)
    724. PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma. (PubMed id 21113787)1 Rodriguez E.F....Rodriguez F.J. (Acta Neuropathol. 2011)
    725. Alternative HER/PTEN/Akt pathway activation in HPV positive and negative penile carcinomas. (PubMed id 21407808)1 Stankiewicz E....Berney D.M. (PLoS ONE 2011)
    726. Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2I+ contributes to human bladder cancer cell survival. (PubMed id 21592330)1 Shimada K....Konishi N. (BMC Urol 2011)
    727. Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1. (PubMed id 21355052)1 Cheng C.J. and Huang C.L. (J. Am. Soc. Nephrol. 2011)
    728. The serine/threonine kinase ULK1 is a target of multiple phosphorylation events. (PubMed id 21819378)1 Bach M....Ramm G. (Biochem. J. 2011)
    729. The relationship among neuregulin 1-stimulated phosphorylation of AKT, psychosis proneness, and habituation of arousal in nonclinical individuals. (PubMed id 19549627)1 KAcri S....Benedek G. (Schizophr Bull 2011)
    730. Genetic studies of the protein kinase AKT1 in Parkinson's disease. (PubMed id 21741444)1 Ran C....Belin A.C. (Neurosci. Lett. 2011)
    731. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    732. Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt. (PubMed id 21444773)1 Sakamaki J....Fukamizu A. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    733. Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration. (PubMed id 21480388)1 Yadav V. and Denning M.F. (Mol. Carcinog. 2011)
    734. Dominant inhibition of Akt/protein kinase B signaling by the matrix protein of a negative-strand RNA virus. (PubMed id 20980511)1 Dunn E.F. and Connor J.H. (J. Virol. 2011)
    735. AKT1 moderation of cannabis-induced cognitive alterations in psychotic disorder. (PubMed id 21775978)1 van Winkel R....Simons C. (Neuropsychopharmacology 2011)
    736. Autophagy and Akt promote survival in glioma. (PubMed id 21266843)1 Fan Q.W. and Weiss W.A. (Autophagy 2011)
    737. A regulatory mechanism involving TBP-1/Tat-Binding Protein 1 and Akt/PKB in the control of cell proliferation. (PubMed id 21991300)1 Sepe M....Pollice A. (PLoS ONE 2011)
    738. Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway. (PubMed id 21799016)1 Mittal Y....Ghosh P. (J. Biol. Chem. 2011)
    739. Targeting AKT protein kinase in gastric cancer. (PubMed id 22199303)1 Almhanna K....Malafa M. (Anticancer Res. 2011)
    740. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. (PubMed id 21670080)1 Coloff J.L....Rathmell J.C. (Cancer Res. 2011)
    741. Targeting PI3K/Akt/HSP90 signaling sensitizes gastric cancer cells to deoxycholate-induced apoptosis. (PubMed id 20585984)1 Redlak M.J. and Miller T.A. (Dig. Dis. Sci. 2011)
    742. Antioxidant c-FLIP inhibits Fas ligand-induced NF-kappaB activation in a phosphatidylinositol 3-kinase/Akt-dependent manner. (PubMed id 21856935)1 Iyer A.K....Rojanasakul Y. (J. Immunol. 2011)
    743. Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells. (PubMed id 21881167)1 Taylor J.R....McCubrey J.A. (Oncotarget 2011)
    744. Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells. (PubMed id 21777670)1 Grabinski N....JA1cker M. (Cell. Signal. 2011)
    745. I+VI^3 integrin regulates macrophage inflammatory responses via PI3 kinase/Akt-dependent NF-I_B activation. (PubMed id 20672329)1 Antonov A.S....Verin A.D. (J. Cell. Physiol. 2011)
    746. Constitutively expressed COX-2 in osteoblasts positively regulates Akt signal transduction via suppression of PTEN activity. (PubMed id 20854947)1 Li C.J....Ho M.L. (Bone 2011)
    747. PPAR-I^ ligands repress TGFI^-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis. (PubMed id 21253589)1 Kulkarni A.A....Sime P.J. (PLoS ONE 2011)
    748. Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas. (PubMed id 21945955)1 Yamaguchi H....Furukawa T. (Am. J. Surg. Pathol. 2011)
    749. Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells. (PubMed id 21869603)1 Steelman L.S....McCubrey J.A. (Cell Cycle 2011)
    750. Vimentin is a novel AKT1 target mediating motility and invasion. (PubMed id 20856200)1 Zhu Q.S....Lev D. (Oncogene 2011)
    751. Critical role of PI3K/Akt/GSK3I^ in motoneuron specification from human neural stem cells in response to FGF2 and EGF. (PubMed id 21887250)1 Ojeda L....Wu P. (PLoS ONE 2011)
    752. TGF-beta1-induced PI3K/Akt/NF-kappaB/MMP9 signalling pathway is activated in Philadelphia chromosome-positive chronic myeloid leukaemia hemangioblasts. (PubMed id 21288887)1 Zhu X....Zhao R.C. (J. Biochem. 2011)
    753. Effective targeting of triple-negative breast cancer cells by PF-4942847, a novel oral inhibitor of Hsp 90. (PubMed id 21715568)1 Mehta P.P....Yin M.J. (Clin. Cancer Res. 2011)
    754. Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladder. (PubMed id 21707707)1 Sun C.H....Pan C.C. (Histopathology 2011)
    755. Akt1 is essential for postnatal mammary gland development, function, and the expression of Btn1a1. (PubMed id 21915327)1 LaRocca J....Hixon M. (PLoS ONE 2011)
    756. Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells. (PubMed id 21308747)1 Thayyullathil F....Galadari S. (J. Cell. Biochem. 2011)
    757. An Akt-dependent increase in canonical Wnt signaling and a decrease in sclerostin protein levels are involved in strontium ranelate-induced osteogenic effects in human osteoblasts. (PubMed id 21566129)1 Rybchyn M.S....Mason R.S. (J. Biol. Chem. 2011)
    758. I^-catenin/Tcf-4 complex transcriptionally regulates AKT1 in glioma. (PubMed id 21720709)1 Chen L....Kang C. (Int. J. Oncol. 2011)
    759. EGFR-AKT-Smad signaling promotes formation of glioma stem-like cells and tumor angiogenesis by ID3-driven cytokine induction. (PubMed id 21975932)1 Jin X....Kim H. (Cancer Res. 2011)
    760. Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines. (PubMed id 21380726)1 Jang E.R....Lee C.S. (Mol. Cell. Biochem. 2011)
    761. Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma. (PubMed id 22199277)1 Schulten H.J....Al-Qahtani M. (Anticancer Res. 2011)
    762. Akt/Nox2/NF-I_B signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation. (PubMed id 21029719)1 Zhang H.S....Wang Y.O. (Arch. Biochem. Biophys. 2011)
    763. Clk2 and B56-beta mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt. (PubMed id 21329884)2 Rodgers J.T.... Puigserver P. (Mol. Cell 2011)
    764. Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis. (PubMed id 21339740)1 Kim E.K....Bae S.S. (Oncogene 2011)
    765. IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation. (PubMed id 21908616)1 Guo J.P....Cheng J.Q. (J. Biol. Chem. 2011)
    766. Differences in myocardial PTEN expression and Akt signalling in type 2 diabetic and nondiabetic patients undergoing coronary bypass surgery. (PubMed id 21521253)1 Wang B....Ansley D.M. (Clin. Endocrinol. (Oxf) 2011)
    767. Icariside II enhances Nrf2 nuclear translocation to upregulate phase II detoxifying enzyme expression coupled with the ERK, Akt and JNK signaling pathways. (PubMed id 22051934)1 Gu J....Chi M. (Molecules 2011)
    768. Cell-type-specific regulation of raft-associated Akt signaling. (PubMed id 21490677)1 Liu Y....Jia W. (amp 2011)
    769. Nef inhibits glucose uptake in adipocytes and contributes to insulin resistance in human immunodeficiency virus type I infection. (PubMed id 21606541)1 Cheney L....Steigbigel R.T. (J. Infect. Dis. 2011)
    770. Glucose deprivation activates AMPK and induces cell death through modulation of Akt in ovarian cancer cells. (PubMed id 21570709)1 Priebe A....Liu J.R. (Gynecol. Oncol. 2011)
    771. The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling. (PubMed id 21914810)1 Rapley J....Avruch J. (J. Biol. Chem. 2011)
    772. A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt. (PubMed id 21667138)1 Mehta R.R....Das Gupta T.K. (Angiogenesis 2011)
    773. mda-9/Syntenin protein positively regulates the activation of Akt protein by facilitating integrin-linked kinase adaptor function during adhesion to type I collagen. (PubMed id 21828040)1 Hwangbo C....Lee J.H. (J. Biol. Chem. 2011)
    774. Low expression of PP2A regulatory subunit B55I+ is associated with T308 phosphorylation of AKT and shorter complete remission duration in acute myeloid leukemia patients. (PubMed id 21660042)1 Ruvolo P.P....Kornblau S.M. (Leukemia 2011)
    775. Syk activation of phosphatidylinositol 3-kinase/Akt prevents HtrA2-dependent loss of X-linked inhibitor of apoptosis protein (XIAP) to promote survival of Epstein-Barr virus+ (EBV+) B cell lymphomas. (PubMed id 21908615)1 Hatton O....Martinez O.M. (J. Biol. Chem. 2011)
    776. MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks. (PubMed id 21623170)1 Fraser M....Bristow R.G. (Cell Cycle 2011)
    777. Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endothelium. (PubMed id 22174934)1 Dellinger M.T. and Brekken R.A. (PLoS ONE 2011)
    778. Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. (PubMed id 21507933)1 Endersby R....Baker S.J. (Cancer Res. 2011)
    779. Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway. (PubMed id 22208359)1 Tarassishin L....Lee S.C. (J Neuroinflammation 2011)
    780. Normal endometrial stromal cells regulate survival and apoptosis signaling through PI3K/AKt/Survivin pathway in endometrial adenocarcinoma cells in vitro. (PubMed id 21794903)1 Shi M....Zhao X. (Gynecol. Oncol. 2011)
    781. Id1 promotes lung cancer cell proliferation and tumor growth through Akt-related pathway. (PubMed id 21536374)1 Cheng Y.J....Yuan S.S. (Cancer Lett. 2011)
    782. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
    783. Genomewide analysis of inherited variation associated with phosphorylation of PI3K/AKT/mTOR signaling proteins. (PubMed id 21949775)1 Hutz J.E....McLeod H.L. (PLoS ONE 2011)
    784. RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3-K/Akt pathway. (PubMed id 21212275)1 Wang F.... Shibuya M. (J. Biol. Chem. 2011)
    785. The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas. (PubMed id 22107784)1 Valkov A....Busund L.T. (J Transl Med 2011)
    786. Herpes simplex virus requires VP11/12 to activate Src family kinase-phosphoinositide 3-kinase-Akt signaling. (PubMed id 21228233)1 Wagner M.J. and Smiley J.R. (J. Virol. 2011)
    787. TLR2 ligand induces protection against cerebral ischemia/reperfusion injury via activation of phosphoinositide 3-kinase/Akt signaling. (PubMed id 21709150)1 Lu C....Li C. (J. Immunol. 2011)
    788. E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via I^-catenin-Egr1-mediated PTEN expression. (PubMed id 21297666)1 Lau M.T....Leung P.C. (Oncogene 2011)
    789. Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3I^ and TGF-I^1-Smad signalling. (PubMed id 21632881)1 Yan L....Li H. (Cardiovasc. Res. 2011)
    790. PML-RARI+ enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway. (PubMed id 21673516)1 Huang Y....Chen G.Q. (Autophagy 2011)
    791. Akt fine-tunes NF-I_B-dependent gene expression during T cell activation. (PubMed id 21862580)1 Cheng J....Kane L.P. (J. Biol. Chem. 2011)
    792. Akt signalling in health and disease. (PubMed id 21620960)2 Hers I.... Tavare J.M. (Cell. Signal. 2011)
    793. Role of peroxisome proliferator-activated receptor gamma coactivator 1alpha in AKT/PKB-mediated inhibition of hepatitis B virus biosynthesis. (PubMed id 21880746)1 Ondracek C.R. and McLachlan A. (J. Virol. 2011)
    794. Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling. (PubMed id 21168265)1 He X....Eng C. (Cancer Lett. 2011)
    795. Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer. (PubMed id 21975935)1 Yoo Y.A....Oh S.C. (Cancer Res. 2011)
    796. Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model. (PubMed id 21460223)1 Jimenez S....Vitorica J. (J. Biol. Chem. 2011)
    797. Serotonin activates MAP kinase and PI3K/Akt signaling pathways in prostate cancer cell lines. (PubMed id 19926313)1 Dizeyi N....Abrahamsson P.A. (Urol. Oncol. 2011)
    798. Phospho-ERK and AKT status, but not KRAS mutation status, are associated with outcomes in rectal cancer treated with chemoradiotherapy. (PubMed id 21910869)1 Davies J.M....O'Neil B.H. (Radiat Oncol 2011)
    799. Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer. (PubMed id 21406404)1 Gonzalez M.E....Kleer C.G. (Cancer Res. 2011)
    800. Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis. (PubMed id 21646299)1 Numata T....Kuwano K. (J. Immunol. 2011)
    801. Recent development of anticancer therapeutics targeting Akt. (PubMed id 21110830)1 Morrow J.K....Zhang S. (Recent Pat Anticancer Drug Discov 2011)
    802. Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. (PubMed id 21464312)1 Jo H....Luo H.R. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    803. PPARI+ and PPARI^ protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling. (PubMed id 21840940)1 Huang W....Toborek M. (FASEB J. 2011)
    804. Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway. (PubMed id 21697490)1 Lin P.H....Chang S.Y. (J. Virol. 2011)
    805. AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. (PubMed id 21884932)1 Sykes S.M....Scadden D.T. (Cell 2011)
    806. Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. (PubMed id 21669872)1 Buhrmann C....Shakibaei M. (J. Biol. Chem. 2011)
    807. Norovirus RNA-dependent RNA polymerase is phosphorylated by an important survival kinase, Akt. (PubMed id 21849454)1 Eden J.S....Brown A.J. (J. Virol. 2011)
    808. Mutational analysis of PTEN/PIK3CA/AKT pathway in oral squamous cell carcinoma. (PubMed id 21824802)1 Cohen Y....Hirshberg A. (Oral Oncol. 2011)
    809. Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase. (PubMed id 21767636)1 Su C.H....Lee W.P. (Cell. Signal. 2011)
    810. von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage. (PubMed id 21358672)1 Roe J.S....Youn H.D. (Oncogene 2011)
    811. Roles of AKT1 and AKT2 in non-small cell lung cancer cell survival, growth, and migration. (PubMed id 21722267)1 Lee M.W....Koo H.H. (Cancer Sci. 2011)
    812. Effect of eccentric exercise velocity on akt/mtor/p70(s6k) signaling in human skeletal muscle. (PubMed id 21609291)1 Roschel H....Tricoli V. (Appl Physiol Nutr Metab 2011)
    813. Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma. (PubMed id 21859846)1 Schatz J.H....Wendel H.G. (J. Exp. Med. 2011)
    814. PTEN, pAKT, and pmTOR expression and subcellular distribution in primary renal cell carcinomas and their metastases. (PubMed id 21696297)1 Hager M....Kolbitsch C. (Cancer Invest. 2011)
    815. IKKI^ and NF-I_B transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1. (PubMed id 21987722)1 Sommermann T.G....Cahir-McFarland E. (Cancer Res. 2011)
    816. Akt/PKB isoforms expression in the human lumbar herniated disc: correlation with clinical and MRI findings. (PubMed id 21590431)1 Pasku D....Spandidos D.A. (Eur Spine J 2011)
    817. Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating the Src/PI3K/Akt pathway. (PubMed id 21994334)1 Liu H....Gu J. (Cancer Res. 2011)
    818. Cigarette smoke induces Akt protein degradation by the ubiquitin-proteasome system. (PubMed id 21778238)1 Kim S.Y....Lee Y.S. (J. Biol. Chem. 2011)
    819. PrLZ protects prostate cancer cells from apoptosis induced by androgen deprivation via the activation of Stat3/Bcl-2 pathway. (PubMed id 21385902)1 Zhang D....Li L. (Cancer Res. 2011)
    820. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    821. LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations. (PubMed id 21658387)1 Ohta E....Obata F. (FEBS Lett. 2011)
    822. Opposite effects of HIV-1 p17 variants on PTEN activation and cell growth in B cells. (PubMed id 21423810)1 Giagulli C....Caruso A. (PLoS ONE 2011)
    823. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (Haematologica 2011)
    824. Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression. (PubMed id 21276823)1 Kwiatkowska A....Kaminska B. (Biochim. Biophys. Acta 2011)
    825. Insulin-activated Akt rescues AI^ oxidative stress-induced cell death by orchestrating molecular trafficking. (PubMed id 21624038)1 Picone P....Di Carlo M. (Aging Cell 2011)
    826. Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner. (PubMed id 21445305)1 Yung H.W....Burton G.J. (PLoS ONE 2011)
    827. Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation. (PubMed id 21742779)1 Castino R....Isidoro C. (Toxicol. Sci. 2011)
    828. Interleukin-10-induced gene expression and suppressive function are selectively modulated by the PI3K-Akt-GSK3 pathway. (PubMed id 21255011)1 Antoniv T.T. and Ivashkiv L.B. (Immunology 2011)
    829. Growth factor receptors gene expression and Akt phosphorylation in benign human thyroid nodules are unaffected by chronic thyrotropin suppression. (PubMed id 20886414)1 Sponziello M.L....Russo D. (Horm. Metab. Res. 2011)
    830. A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability. (PubMed id 21151116)1 Esteve P.O.... Pradhan S. (Nat. Struct. Mol. Biol. 2011)
    831. Bimodal regulation of FoxO3 by AKT and 14-3-3. (PubMed id 21621563)1 Dobson M....Tzivion G. (Biochim. Biophys. Acta 2011)
    832. Modulation of PGE2-induced EP4 expression on snail signaling and the impact on epithelial-mesenchymal transition: significance of EP4 antagonism. (PubMed id 22199300)1 Kim H.N....Narayanan B. (Anticancer Res. 2011)
    833. Discovery and SAR of spirochromane Akt inhibitors. (PubMed id 21392984)2 Kallan N.C.... Skelton N.J. (Bioorg. Med. Chem. Lett. 2011)
    834. ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells. (PubMed id 22169232)1 Shen Z....Wang X. (Cold Spring Harb. Symp. Quant. Biol. 2011)
    835. Lack of compensatory pAKT activation and eIF4E phosphorylation of lymphoma cells towards mTOR inhibitor, RAD001. (PubMed id 21334199)1 Kuo S.H....Cheng A.L. (Eur. J. Cancer 2011)
    836. Interplay between FOXO, TOR, and Akt. (PubMed id 21440577)1 Hay N. (Biochim. Biophys. Acta 2011)
    837. TGF-I^ stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle. (PubMed id 21913799)1 Osman N....Little P.J. (Growth Factors 2011)
    838. Cellular repressor of E1A-stimulated genes regulates vascular endothelial cell migration by the ILK/AKT/mTOR/VEGF(165) signaling pathway. (PubMed id 21939655)1 Zhang H....Li S. (Exp. Cell Res. 2011)
    839. Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial colon cells. (PubMed id 21482133)1 KoA8A- L....KozubA-k A. (Cytokine 2011)
    840. Direct interaction of I+-synuclein and AKT regulates IGF-1 signaling: implication of Parkinson disease. (PubMed id 21474915)1 Chung J.Y....Park B.J. (Neurosignals 2011)
    841. GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment. (PubMed id 21454528)1 Elsawa S.F....Fernandez-Zapico M.E. (J. Biol. Chem. 2011)
    842. IL-17 induces AKT-dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma. (PubMed id 22171994)1 Gu F.M....Zhou J. (Mol. Cancer 2011)
    843. Matrix-dependent regulation of AKT in Hepsin-overexpressing PC3 prostate cancer cells. (PubMed id 21750652)1 Wittig-Blaich S.M....Wittig R. (Neoplasia 2011)
    844. SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival. (PubMed id 21685937)1 Fenouille N....Tartare-Deckert S. (Oncogene 2011)
    845. Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells. (PubMed id 21828127)1 Wehrens E.J....van Wijk F. (Blood 2011)
    846. Regulation of FOXO protein stability via ubiquitination and proteasome degradation. (PubMed id 21238503)1 Huang H. and Tindall D.J. (Biochim. Biophys. Acta 2011)
    847. Critical role for programmed death 1 signaling and protein kinase B in augmented regulatory T-cell induction in cord blood. (PubMed id 21868077)1 de Roock S....de Kleer I.M. (J. Allergy Clin. Immunol. 2011)
    848. Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/I^-catenin signaling. (PubMed id 21325624)1 Kolegraff K....Nusrat A. (Mol. Biol. Cell 2011)
    849. Wnt/I^-catenin signaling regulates MAPK and Akt1 expression and growth of hepatocellular carcinoma cells. (PubMed id 21391741)1 Wang X.H....Xu W. (Neoplasma 2011)
    850. Akt associates with nuclear factor kappaB and plays an important role in chemoresistance of gastric cancer cells. (PubMed id 20514451)1 Yu L.L....Si J.M. (Oncol. Rep. 2010)
    851. The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors. (PubMed id 19897009)1 Saji M. and Ringel M.D. (Mol. Cell. Endocrinol. 2010)
    852. In vitro evaluation of pan-PI3-kinase inhibitor SF1126 in trastuzumab-sensitive and trastuzumab-resistant HER2-over-expressing breast cancer cells. (PubMed id 19636556)1 Ozbay T....Nahta R. (Cancer Chemother. Pharmacol. 2010)
    853. Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways. (PubMed id 19609946)1 Ghayad S.E....Cohen P.A. (Int. J. Cancer 2010)
    854. Reciprocal regulation of AKT and MAP kinase dictates virus-host cell fusion. (PubMed id 20164223)1 Sharma N.R....Sarkar D.P. (J. Virol. 2010)
    855. miR-22 forms a regulatory loop in PTEN/AKT pathway and modulates signaling kinetics. (PubMed id 20523723)1 Bar N. and Dikstein R. (PLoS ONE 2010)
    856. Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage. (PubMed id 20187936)1 GarcA-a S....Conde C. (amp 2010)
    857. The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin. (PubMed id 20395438)1 Metalli D....Morrione A. (Am. J. Pathol. 2010)
    858. Stathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway. (PubMed id 20657188)1 Wang X....Zhang H.Z. (amp 2010)
    859. Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling. (PubMed id 20488790)1 van de Laar L....Woltman A.M. (J. Immunol. 2010)
    860. Upregulation of DLX5 promotes ovarian cancer cell proliferation by enhancing IRS-2-AKT signaling. (PubMed id 21045156)1 Tan Y....Testa J.R. (Cancer Res. 2010)
    861. Beta-arrestin-1 mediates the endothelin-1-induced activation of Akt and integrin-linked kinase. (PubMed id 20725137)1 Cianfrocca R....Bagnato A. (Can. J. Physiol. Pharmacol. 2010)
    862. Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2. (PubMed id 20534535)1 Mund T. and Pelham H.R. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    863. Immunosuppressive cyclosporin A activates AKT in keratinocytes through PTEN suppression: implications in skin carcinogenesis. (PubMed id 20154081)1 Han W....He Y.Y. (J. Biol. Chem. 2010)
    864. Wingless (Wnt)-3A induces trophoblast migration and matrix metalloproteinase-2 secretion through canonical Wnt signaling and protein kinase B/AKT activation. (PubMed id 19887570)1 Sonderegger S....KnAPfler M. (Endocrinology 2010)
    865. Ovarian cancer ascites protects from TRAIL-induced cell death through alphavbeta5 integrin-mediated focal adhesion kinase and Akt activation. (PubMed id 20400979)1 Lane D....PichAc A. (Oncogene 2010)
    866. DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4. (PubMed id 20829512)1 Sanematsu F....Fukui Y. (Circ. Res. 2010)
    867. Inhibitory effect of baicalein on IL-6-mediated signaling cascades in human myeloma cells. (PubMed id 19878271)1 Liu S....Kawano M. (Eur. J. Haematol. 2010)
    868. miR-149* induces apoptosis by inhi