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GIFtS

AKT1 Gene

protein-coding   GIFtS: 79
GCID: GC14M105235

v-akt murine thymoma viral oncogene homolog 1
 Explore 200 diseases affiliated with
AKT1 via
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Biological research products
for AKT1    

Aliases
for AKT1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
V-Akt Murine Thymoma Viral Oncogene Homolog 11 2     PKB Alpha2 3
PKB1 2 3     EC 2.7.11.13 8
RAC1 2 3     PKB-ALPHA2
AKT1 2     RAC-ALPHA2
PRKBA1 2     Rac Protein Kinase Alpha2
Protein Kinase B Alpha2 3     RAC-Alpha Serine/Threonine-Protein Kinase2
Proto-Oncogene C-Akt2 3     Protein Kinase B3
RAC-PK-Alpha1     EC 2.7.118

External Ids:    HGNC: 3911   Entrez Gene: 2072   Ensembl: ENSG000001422087   OMIM: 1647305   UniProtKB: P317493   

Export aliases for AKT1 gene to outside databases

Previous GC identifers: GC14M102614 GC14M099226 GC14M103207 GC14M104361 GC14M085432


Summaries
for AKT1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AKT1:
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and
immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is
rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the
activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator
of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent
manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the
apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively
spliced transcript variants have been found for this gene. (provided by RefSeq, Jul 2011)

UniProtKB/Swiss-Prot: AKT1_HUMAN, P31749
Function: AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT
kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis.
This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100
substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is
responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose
transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity
preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of
TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated
glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at
'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT
is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the
phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase
activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein
synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both
phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO
factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic
localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are
phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene
transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The
phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of
pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby
potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide
phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of
lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho
GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell
proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the
tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning,
dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate
the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF),
insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the
SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation
of the placental development. Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase
activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at
'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180,
binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and
ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity.
Phosphorylation of BAD stimulates its pro-apoptotic activity
Function: AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation
modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism
and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic
relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and
proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation

summary for AKT1:
Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival,
insulin signaling, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway,
resulting in the recruitment of Akt to the plasma membrane via the PH (plexstrin homology domain) of Akt.
Akt is fully activated by phosphorylation at two key sites: Ser308 (phosphorylated by PDK1) and Thr478
(phosphorylated by mTOR and DNA-PK). Akt can then phosphorylated a wide range of substrates including
transcription factors (e.g. FOXO1), kinases (GSK-3, Raf-1, ASK, Chk1) and other proteins with important
signaling roles (e.g. Bad, MDM2). There are three isoforms of Akt; Akt 1, 2 and 3 (also known as PKBalpha,
beta and gamma).

Gene Wiki entry for AKT1


Genomic Views
for AKT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AKT1 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AKT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AKT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.32   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.32-q32.33

AKT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKT1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M105235:  view genomic region     (about GC identifiers)

Start:
 105,235,686 bp from pter      End:
 105,262,088 bp from pter
Size:
 26,403 bases      Orientation:
 minus strand

Proteins
for AKT1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AKT1_HUMAN, P31749 (See protein sequence)
Recommended Name: RAC-alpha serine/threonine-protein kinase  
Size: 480 amino acids; 55686 Da
Subunit: Interacts (via the C-terminus) with CCDC88A (via its C-terminus). Interacts with GRB10; the interaction leads
to GRB10 phosphorylation thus promoting YWHAE-binding (By similarity). Interacts with AGAP2 (isoform 2/PIKE-A); the
interaction occurs in the presence of guanine nucleotides. Interacts with AKTIP. Interacts (via PH domain) with MTCP1,
TCL1A AND TCL1B. Interacts with CDKN1B; the interaction phosphorylates CDKN1B promoting 14-3-3 binding and cell-cycle
progression. Interacts with MAP3K5 and TRAF6. Interacts with BAD, PPP2R5B, STK3 and STK4. Interacts (via PH domain)
with SIRT1. Interacts with SRPK2 in a phosphorylation-dependent manner. Interacts with RAF1. Interacts with TRIM13;
the interaction ubiquitinates AKT1 leading to its proteasomal degradation. Interacts with TNK2 and CLK2. Interacts
(via the C-terminus) with THEM4 (via its C-terminus). Interacts with and phosphorylated by PDPK1
Subcellular location: Cytoplasm. Nucleus. Cell membrane. Note=Nucleus after activation by integrin-linked protein
kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2
results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and
Ser-473 leading to its activation and the activated form translocates to the nucleus
Caution: In light of strong homologies in the primary amino acid sequence, the 3 AKT kinases were long surmised to play
redundant and overlapping roles. More recent studies has brought into question the redundancy within AKT kinase
isoforms and instead pointed to isoform specific functions in different cellular events and diseases. AKT1 is more
specifically involved in cellular survival pathways, by inhibiting apoptotic processes; whereas AKT2 is more specific
for the insulin receptor signaling pathway. Moreover, while AKT1 and AKT2 are often implicated in many aspects of
cellular transformation, the 2 isoforms act in a complementary opposing manner. The role of AKT3 is less clear, though
it appears to be predominantly expressed in brain
6/20 PDB 3D structures from and Proteopedia for AKT1 (see all 20):
1H10 (3D)        1UNP (3D)        1UNQ (3D)        1UNR (3D)        2UVM (3D)        2UZR (3D)    
Secondary accessions: B2RAM5 Q9BWB6

Explore the universe of human proteins at neXtProt for AKT1: NX_P31749

Post-translational modifications:

  • O-GlcNAcylation at Thr-305 and Thr-312 inhibits activating phosphorylation at Thr-308 via disrupting the interaction
    • between AKT1 and PDPK1. O-GlcNAcylation at Ser-473 also probably interferes with phosphorylation at this site1
  • Phosphorylation on Thr-308, Ser-473 and Tyr-474 is required for full activity. Activated TNK2 phosphorylates it on
    • Tyr-176 resulting in its binding to the anionic plasma membrane phospholipid PA. This phosphorylated form localizes to
    the cell membrane, where it is targeted by PDPK1 and PDPK2 for further phosphorylations on Thr-308 and Ser-473 leading
    to its activation. Ser-473 phosphorylation by mTORC2 favors Thr-308 phosphorylation by PDPK1. Ser-473 phosphorylation
    is enhanced by interaction with AGAP2 isoform 2 (PIKE-A). Ser-473 phosphorylation is enhanced in focal cortical
    dysplasias with Taylor-type balloon cells. Ser-473 phosphorylation is enhanced by signaling through activated FLT3.
    Dephosphorylated at Thr-308 and Ser-473 by PP2A phosphatase. The phosphorylated form of PPP2R5B is required for
    bridging AKT1 with PP2A phosphatase1
  • Ubiquitinated via 'Lys-48'-linked polyubiquitination by ZNRF1, leading to its degradation by the proteasome (By
    • similarity). Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. TRAF6-induced
    'Lys-63'-linked AKT1 ubiquitination is critical for phosphorylation and activation. When ubiquitinated, it
    translocates to the plasma membrane, where it becomes phosphorylated. When fully phosphorylated and translocated into
    the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome.
    Also ubiquitinated by TRIM13 leading to its proteasomal degradation1
  • Acetylated on Lys-14 and Lys-20 by the histone acetyltransferases EP300 and KAT2B. Acetylation results in reduced
    • phosphorylation and inhibition of activity. Deacetylated at Lys-14 and Lys-20 by SIRT1. SIRT1-mediated deacetylation
    relieves the inhibition1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P31749

    • 4/35 DME Specific Peptides for AKT1 (P31749) (see all 35)
     VVYRDLK  YYAMKIL  GVVMYEM  AEIVSAL 

    AKT1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001014431.1  NP_001014432.1  NP_005154.2  

    ENSEMBL proteins: 
     ENSP00000451828   ENSP00000384293   ENSP00000270202   ENSP00000385326   ENSP00000450688  
     ENSP00000451470   ENSP00000450681   ENSP00000443897   ENSP00000451166   ENSP00000451290  
     ENSP00000451824  
    Reactome Protein details: P31749
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant AKT1 Protein
    R&D Systems Recombinant & Natural Proteins for AKT1
    Enzo Life Sciences proteins for AKT1
    OriGene Purified Proteins (see all 3): AKT1
    OriGene Protein Over-expression Lysate (see all 4): AKT1
    OriGene Custom Protein Services for AKT1 
    GenScript Custom Purified and Recombinant Proteins Services for AKT1
    Novus Biologicals AKT1 Proteins
    Novus Biologicals AKT1 Lysates
    Sino Biological Recombinant Protein for AKT1
    ProSpec Recombinant Protein for AKT1
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005634nucleus TAS--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS--
    GO:0005819spindle IEA--


    AKT1 for ontologies           About GeneDecksing



    AKT1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of AKT1
    R&D Systems Antibodies for AKT1
    Cell Signaling Technology (CST) Antibodies for AKT1 
    OriGene Antibodies (see all 20): AKT1
    OriGene Custom Antibody Services for AKT1 
    GenScript Superior Antibodies for AKT1
    Novus Biologicals AKT1 Antibodies
    Abcam antibodies for AKT1 
    Browse Antibodies at Uscn
    ThermoFisher Antibody for AKT1

    Assay Products for AKT1: 
    EMD Millipore Kits and Assays for the Analysis of AKT1
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for AKT1         (see all)
    GenScript AKT1-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for AKT1
    Enzo Life Sciences assays for AKT1
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for AKT1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AKT1 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry P31749

    ProtoNet protein and cluster: P31749

    2 Blocks protein families:
    IPB000961 Protein kinase C-terminal domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: AKT1_HUMAN, P31749
    Domain: Binding of the PH domain to phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) following
    phosphatidylinositol 3-kinase alpha (PIK3CA) activity results in its targeting to the plasma membrane. The PH domain
    mediates interaction with TNK2 and Tyr-176 is also essential for this interaction
    Domain: The AGC-kinase C-terminal mediates interaction with THEM4
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 protein kinase domain


    Function
    for AKT1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AKT1_HUMAN, P31749
    Function: AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT
    kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis.
    This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100
    substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is
    responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose
    transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity
    preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of
    TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated
    glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at
    'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT
    is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the
    phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase
    activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein
    synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both
    phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO
    factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic
    localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are
    phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene
    transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The
    phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of
    pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby
    potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide
    phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of
    lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho
    GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell
    proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the
    tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning,
    dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate
    the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF),
    insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the
    SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation
    of the placental development. Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase
    activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at
    'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180,
    binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and
    ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity.
    Phosphorylation of BAD stimulates its pro-apoptotic activity
    Function: AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation
    modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism
    and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic
    relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and
    proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Three specific sites, one in the kinase domain (Thr-308) and the two other ones in the C-terminal
    regulatory region (Ser-473 and Tyr-474), need to be phosphorylated for its full activation. Inhibited by
    pyrrolopyrimidine inhibitors like aniline triazole and spiroindoline
    Biophysicochemical properties: Kinetic parameters: KM=52.8 uM for ATP (for purified and in vitro activated AKT1);
    KM=0.5 uM for peptide substrate (for purified and in vitro activated AKT1); KM=143.3 uM for ATP (for recombinant
    myristoylated AKT1 expressed and immunoprecipitated from Rat-1 cells); KM=2.9 uM for peptide substrate (for
    recombinant myristoylated AKT1 expressed and immunoprecipitated from Rat-1 cells);

         Genatlas biochemistry entry for AKT1:
    V-akt murine thymoma viral oncogen homolog 1,general mediator of cell survival induced by insulin growth factor 1,AKT1
    and others activated by phosphadidylinositol 3-kinase in the antiapoptotic PIK3 pathway,phosphorylating and
    inactivating components of the apoptotic machinery including BAD,CASP9 and the transcription factor FKHRL1

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
    Products:            		miRTarBase miRNAs that target AKT1:
    hsa-mir-451 (MIRT005740), hsa-mir-125b (MIRT004363), hsa-mir-185 (MIRT004701), hsa-mir-149 (MIRT005355)

    OriGene 3'-UTR Clone (see all 3): AKT1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKT1
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate AKT1 (see all 21):
    hsa-miR-520e hsa-miR-302d hsa-miR-374a hsa-miR-302e hsa-miR-520a-3p hsa-miR-633 hsa-miR-372 hsa-miR-520d-3p
    SwitchGear 3'UTR luciferase reporter plasmid: AKT1 3' UTR sequence
    Inhib. RNA
    Products:            		EMD Millipore RNAi Products for the Analysis of AKT1 Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKT1 (see all 7)
    OriGene shRNA RFP: AKT1
    OriGene siRNA: AKT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKT1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for AKT1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKT1 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKT1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): AKT1 (NM_005163)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKT1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for AKT1
    Search LifeMap BioReagents cell lines for AKT1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKT1

    Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10570282
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0005080protein kinase C binding IEA--
    GO:0005515protein binding IPI19162005
    GO:0005524ATP binding IDA16540465


    AKT1 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for AKT1:
     Decreased p24 protein expressi  Decreased viability after Chla  Decreased viability with TRAIL  Increases Tamoxifen sensitivit 
     Weaker migration  Wnt reporter downregulated 

    Animal Models:
         Mouse knock-outs for AKT1: Akt1tm1Nhy Akt1tm1Mbb Akt1tm2.1Mbb
         15/20 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Akt1) (see all 20):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  embryogenesis 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  muscle  nervous system 

    AKT1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for AKT1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/223 super-pathways (see all 223) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_CNTF receptor signaling
    8/19 pathways (see all 19)
    		Development_CNTF receptor signaling1.00
    		Development_Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Development CNTF receptor signaling1.00
    		Development Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Transcription Receptor-mediated HIF regulation0.43
    		Translation _Regulation of EIF4F activity0.32
    		Transcription_Receptor-mediated HIF regulation0.43
    		Translation Regulation activity of EIF4F0.32
    2IL-9 Signaling Pathways
    8/14 pathways (see all 14)
    		IL-9 Signaling Pathways1.00
    		IL-9 Signaling Pathway0.42
    		IL-21 Signaling Pathways0.90
    		IL-7 Signaling Pathway0.38
    		IL-7 Signaling Pathways0.90
    		Development_Thrombopoietin-regulated cell processes0.36
    		Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    		Development Thrombopoietin-regulated cell processes0.36
    3Development HGF signaling pathway
    8/13 pathways (see all 13)
    		Development_HGF signaling pathway0.78
    		Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR10.24
    		Development_Neurotrophin family signaling0.45
    		Apoptosis and survival Anti-apoptotic action of membrane-bound ESR10.24
    		Development Neurotrophin family signaling0.45
    		Apoptosis and survival_Role of CDK5 in neuronal death and survival0.24
    		Development EGFR signaling via PIP30.26
    		Apoptosis and survival Role of CDK5 in neuronal death and survival0.24
    4Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    5PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/67 EMD Millipore Pathways for AKT1 (see all 67)
        Cytoskeleton remodeling FAK signaling
    G-protein signaling G-Protein beta/gamma signaling cascades
    Transcription NF-kB signaling pathway
    Development A2A receptor signaling
    Immune response IL-4 signaling pathway

    5/9 R&D Systems Pathways for AKT1 (see all 9)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    IL-7 Signaling Pathways

    5/90 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AKT1 (see all 90)
        Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    ERK5 Signaling

    2 Cell Signaling Technology (CST) Pathways for AKT1
        PI3K / Akt Signaling
    Glucose / Energy Metabolism

    5/8 Tocris Bioscience Pathways for AKT1 (see all 8)
        Akt Pathway
    Insulin Pathway
    Toll-like Receptor Pathway
    Apoptosis Pathway
    TGF-beta Pathway

    5/70 GeneGo (Thomson Reuters) Pathways for AKT1 (see all 70)
        Development A2A receptor signaling
    Development CNTF receptor signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Signal transduction AKT signaling

    5/102 BioSystems Pathways for AKT1 (see all 102) 
        AMPK signaling
    TOR signaling
    Signal Transduction of S1P Receptor
    Focal Adhesion
    AGE/RAGE pathway

    5/69        Reactome Pathways for AKT1 (see all 69)
        Downregulation of ERBB2:ERBB3 signaling
    AKT1/2 Phosphorylates AS160 (TBC1D4)
    Intrinsic Pathway for Apoptosis
    Signaling by PDGF
    Downstream Signaling Events Of B Cell Receptor (BCR)

    5 PharmGKB Pathways for AKT1
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
    Celecoxib Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics
    VEGF Signaling Pathway

    5/39         Kegg Pathways  (Kegg details for AKT1) (see all 39):
        MAPK signaling pathway
    ErbB signaling pathway
    Chemokine signaling pathway
    mTOR signaling pathway
    Apoptosis


    AKT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AKT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/369 Interacting proteins for AKT1 (P317491, 2, 3 ENSP000002702024) via UniProtKB, MINT, STRING, and/or I2D (see all 369)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK4Q130432, 3, ENSP000003618924MINT-6175011 MINT-6175193 MINT-6175251 MINT-6175225 MINT-6174722 MINT-6175034 MINT-6175070 MINT-6175132 MINT-6175047 MINT-6175025 MINT-6175115 MINT-6175085 MINT-6175239 I2D: score=2 STRING: ENSP00000361892
    SORBS2O948752, 3, ENSP000002847764MINT-61344 MINT-61469 MINT-61464 MINT-61466 MINT-61479 MINT-61468 MINT-61467 MINT-61463 MINT-61346 MINT-61345 MINT-61462 MINT-61465 I2D: score=2 STRING: ENSP00000284776
    PLCG1P191742, 3, ENSP000002440074MINT-7146749 MINT-7146647 MINT-7146716 MINT-7146688 MINT-7146767 MINT-7146702 MINT-7146731 MINT-7146657 MINT-7146671 I2D: score=1 STRING: ENSP00000244007
    GSK3BP498411, 2, 3, ENSP000003248064EBI-296087,EBI-373586 MINT-8392173 I2D: score=6 STRING: ENSP00000324806
    PPP1CAP621362, 3, ENSP000003260314MINT-8291728 MINT-8291740 MINT-8291812 MINT-8291704 MINT-8291680 MINT-8291788 I2D: score=1 STRING: ENSP00000326031
    About this table

    Gene Ontology (GO): 5/99 biological process terms (GO ID links to tree view) (see all 99):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IMP16280327
    GO:0001649osteoblast differentiation IEA--
    GO:0001893maternal placenta development IEA--
    GO:0001934positive regulation of protein phosphorylation IDA19057511
    GO:0005977glycogen metabolic process ----


    AKT1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AKT1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AKT1 for compounds           About GeneDecksing

    EMD Millipore small molecules for AKT1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for AKT1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    10-DEBC hydrochlorideSelective Akt/PKB inhibitor[201788-90-1]
    SC 66Allosteric Akt inhibitor[871361-88-5]
    API-2Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral[35943-35-2]
    FPA 124Akt/PKB inhibitor[902779-59-3]
    GSK 690693Akt kinase inhibitor. Antitumor[937174-76-0]

    3 HMDB Compounds for AKT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    SumatriptanImigran (see all 4)103628-46-2--

    5 DrugBank Compounds for AKT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Arsenic trioxideAcide Arsenieux [French] (see all 11)1327-53-3targetinducer16239170 12472888 15580309 12529330 15916724
    Inositol 1,3,4,5-Tetrakisphosphate-- --target--17139284 17016423
    5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-- --target--10592235
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17041888
    N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine-- --target--10592235

    10/125 Novoseek chemical compound relationships for AKT1 gene (see all 125)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 88.5 246 12551955 (5), 10578066 (5), 8645157 (3), 10671514 (3) (see all 99)
    phosphoinositide 83.7 125 10454216 (4), 10102683 (3), 9671484 (2), 15292195 (2) (see all 88)
    ly294002 83.6 78 15752900 (3), 15347471 (3), 16842970 (3), 10623881 (2) (see all 48)
    wortmannin 83.4 88 17380453 (3), 16458614 (2), 9346964 (2), 9755080 (2) (see all 62)
    threonine 78 116 10362672 (1), 10411946 (1), 10491192 (1), 11279265 (1) (see all 99)
    phosphatidylinositol-3,4,5-trisphosphate 77.6 20 7738099 (1), 15107457 (1), 9228007 (1), 12421919 (1) (see all 18)
    serine 71.1 120 16780593 (3), 16141217 (2), 10362672 (1), 10411946 (1) (see all 99)
    rapamycin 70 48 10623881 (2), 17565979 (2), 10567225 (2), 17616691 (2) (see all 35)
    glycogen 69.9 112 11574400 (5), 10623881 (4), 9478990 (3), 10446195 (2) (see all 68)
    tyrosine 69.3 113 9593727 (3), 7616102 (3), 9415029 (3), 10623881 (2) (see all 79)

    2 PharmGKB related drug/compound annotation for AKT1 gene
    Drug/compound PharmGKB Annotation
    risperidoneCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about AKT1 

    Transcripts
    for AKT1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AKT1 gene (3 alternative transcripts): 
    NM_001014431.1  NM_001014432.1  NM_005163.2  

    Unigene Cluster for AKT1:

    V-akt murine thymoma viral oncogene homolog 1
    Hs.525622  [show with all ESTs]
    Unigene Representative Sequence: AK122894
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554581(uc001ypk.3 uc001ypl.3) ENST00000407796 ENST00000349310(uc001ypm.3 uc001ypn.3)
    ENST00000553506 ENST00000557552(uc001ypj.3 uc010tyk.2) ENST00000402615(uc010axa.3)
    ENST00000555528 ENST00000555458 ENST00000554192 ENST00000544168 ENST00000554585
    ENST00000554848 ENST00000554826 ENST00000556836 ENST00000555380 ENST00000555926
    ENST00000557494 ENST00000553797

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): AKT1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKT1
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate AKT1 (see all 21):
    hsa-miR-520e hsa-miR-302d hsa-miR-374a hsa-miR-302e hsa-miR-520a-3p hsa-miR-633 hsa-miR-372 hsa-miR-520d-3p
    SwitchGear 3'UTR luciferase reporter plasmid: AKT1 3' UTR sequence
    Inhib. RNA
    Products:             		EMD Millipore RNAi Products for the Analysis of AKT1 Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKT1 (see all 7)
    OriGene shRNA RFP: AKT1
    OriGene siRNA: AKT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKT1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKT1 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKT1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): AKT1 (NM_005163)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKT1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKT1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AKT1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKT1

    Additional cDNA sequence: 

    AB451242.1 AB451367.1 AK122894.1 AK299310.1 AK314256.1 BC000479.2 BC001737.1 BC063408.1 
    BC084538.1 BX648205.1 M63167.1 X61037.1 

    24 DOTS entries:

    DT.450038  DT.100059722  DT.100824191  DT.100059719  DT.95090241  DT.100733482  DT.120765970  DT.92461206 
    DT.100824203  DT.102829546  DT.75100119  DT.95341680  DT.100824190  DT.100824201  DT.120765944  DT.95090231 
    DT.95090239  DT.95090245  DT.120765955  DT.120765973  DT.92461194  DT.92461227  DT.95124889  DT.100059721 

    13 AceView cDNA sequences:

    BC000479 AK131465 CR611982 BX648205 BC001737 AK127193 NM_005163 AK122894 
    M63167 BX647722 AK094287 X61037 BC063408 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for AKT1 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^
    SP1:                                                                                      -     -                                                               
    SP2:                                                                                      -     -                                                           -   
    SP3:                                                                                      -     -                                                               
    SP4:                                                                                -     -     -                                                               
    SP5:                                                                                                                                -                       -   

    ExUns: 16 ^ 17a · 17b ^ 18
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for AKT1

    Expression
    for AKT1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AKT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AKT1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Lateral Plate MesodermEmbryonic Blood IslandsAngioblastsEndothelium
    Lateral Plate MesodermEmbryonic Capillary PlexusAngioblastsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See AKT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AKT1

    SOURCE GeneReport for Unigene cluster: Hs.525622

    UniProtKB/Swiss-Prot: AKT1_HUMAN, P31749
    Tissue specificity: Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein
    level). Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant
    increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal
    carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages

        SABiosciences Expression via Pathway-Focused PCR Arrays including AKT1 (see all 37): 
              Lung Cancer in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat
              Mitochondria in human mouse rat
              Breast Cancer in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKT1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AKT1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKT1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKT1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKT1

    Orthologs
    for AKT1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for AKT1 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves AKT11 v-akt murine thymoma viral oncogene homolog 1 76.94(n)
    96.04(a)    		   395928  NM_205055.1  NP_990386.1 
    lizard
    (Anolis carolinensis)    		 Reptilia AKT16
    		 --
    		 96(a)
    		 1 ↔ 1
    		 1(3699783-3754440)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AF317656.12   -- 76.92(n)    AF317656.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii akt2l1 v-akt murine thymoma viral oncogene homolog 2, like 76.02(n)
    77.22(a)    		   403146  NM_212815.1  NP_997980.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Akt13 anti-apoptosis protein serine/threonine
    kinase    		 61(a)   89B6   --
    worm
    (Caenorhabditis elegans)    		 Secernentea akt-11 , 3 PH (pleckstrin homology) domain, Protein
    kinase more3
    Protein AKT-11    		 55(a)
    (best of 2)3
    55.84(n)1
    59.62(a)1    		   V(10251544-10255039)3
    1794241  NM_001028474.31  NP_001023645.11 


    ENSEMBL Gene Tree for AKT1 (if available)
    TreeFam Gene Tree for AKT1 (if available) 

    Paralogs
    for AKT1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AKT1 gene
    RPS6KA62  RPS6KB12  SGK32  SGK22  RPS6KA12  AKT32  RPS6KA52  RPS6KA42  
    SGK12  RPS6KB22  RPS6KA22  AKT22  RPS6KA32  
    18/77 SIMAP similar genes for AKT1 using alignment to 7 protein entries:     AKT1_HUMAN (see all proteins) (see all similar genes):
    AKT2    AKT3    KIN27    PRKCH    SGK2    PRKCZ
    PRKCA    PKN2    PKN1    PRKACB    PRKCE    PRKACA
    PRKCI    RPS6KA2    DKFZp781N0293    SGK3    SGKL    MARK4

    AKT1 for paralogs           About GeneDecksing



    Genomic Variants
    for AKT1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/628 NCBI SNPs in AKT1 are shown (see all 628)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1214345921,2
    		Cother105246551(-) TAGGGA/GAGTAC 6 K E mis10--------
    rs617597971,2
    		C,F,--85446389(-) GACCCG/AGAGTA 1 -- int14Minor allele frequency- A:0.06NS WA 212
    rs617597961,2
    		C,--85447162(-) GCACCT/GAGCCG 1 -- int12Minor allele frequency- G:0.01NS 86
    rs58111531,2
    		C,--85447304(+) AAGGGGGAA/-  
                GGAAG     		1 -- int1 trp31Minor allele frequency- -:0.50CSA 2
    rs617597951,2
    		C,--85447577(-) TGGTGG/AGGAGG 1 -- int12Minor allele frequency- A:0.01NS 92
    rs617597941,2
    		F--85447588(-) GATGTG/CCTGGC 1 -- int12Minor allele frequency- C:0.02NS 92
    rs617597931,2
    		C,F,--85447657(-) AGGAGT/CCTGGC 1 -- int14Minor allele frequency- C:0.07NS CSA WA 212
    rs617597921,2
    		C,F,--85447885(-) ACCCCG/AGTATT 1 -- int14Minor allele frequency- A:0.06NS CSA WA 194
    rs617597911,2
    		C,--85448035(-) GTGCCG/ACTTTG 1 -- int12Minor allele frequency- A:0.01NS 82
    rs740900281,2
    		C,--85448091(+) GGGTGG/AGCCCC 1 -- int12Minor allele frequency- A:0.03WA 120

    HapMap Linkage Disequilibrium report for AKT1 (105235686 - 105262088 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for AKT1
         6 CNVs: 29963 49291 29962 29964 49292 59556
    Human Gene Mutation Database (HGMD): AKT1

    4 SABiosciences Cancer Mutation PCR Assays for AKT1:
    Cosmic IdAA Change
    33765p.E17K
    36918p.E49K
    33765p.E17K
    48226p.F35L
    5/19 SABiosciences Cancer Mutation PCR Arrays containing AKT1 (see all 19):
    Breast Cancer
    Receptor Tyrosine Kinase (RTK) (Panel II)
    Cancer Comprehensive Panel 384HT
    Lung Cancer
    KIT Pathway
    4 SABiosciences qBiomarker Copy Number PCR Arrays containing AKT1:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    Lung Cancer
    Kinases & Phosphatases
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKT1
    DNA2.0 Custom Variant and Variant Library Synthesis for AKT1

    Disorders / Diseases
    for AKT1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AKT1 for disorders           About GeneDecksing

    OMIM gene information: 164730   
    OMIM disorders: 114480  114500  604370  181500  
    UniProtKB/Swiss-Prot: AKT1_HUMAN, P31749
  • Defects in AKT1 are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancy
    • originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive
    ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous.
    Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than
    one locus can be involved in different families or even in the same case
  • Defects in AKT1 are associated with colorectal cancer (CRC) [MIM:114500]
  • Note=Genetic variations in AKT1 may play a role in susceptibility to ovarian cancer
  • Defects in AKT1 are a cause of Proteus syndrome (PROTEUSS) [MIM:176920]. A highly variable, severe disorder of
    • asymmetric and disproportionate overgrowth of body parts, connective tissue nevi, epidermal nevi, dysregulated adipose
    tissue, and vascular malformations. Many features of Proteus syndrome overlap with other overgrowth syndromes

    20/200 diseases for AKT1 (see all 200):    About MalaCards
    proteus syndrome    thymoma    limb-girdle muscular dystrophy    wiskott-aldrich syndrome
    high blood pressure    serous cystadenocarcinoma    diffuse large b-cell lymphoma    focal cortical dysplasia
    ovarian serous cystadenocarcinoma    b-cell lymphomas    salivary gland cancer    smooth muscle tumor
    anaplastic large cell lymphoma    waldenstrom macroglobulinemia    anal squamous cell carcinoma    malignant pleural mesothelioma
    tardive dyskinesia    type 2 diabetes mellitus    fragile x syndrome    major depressive disorder

    20/28 diseases from the University of Copenhagen DISEASES database for AKT1 (see all 28):
    Vascular disease     Breast cancer     Diabetes mellitus     Prostate cancer
    Malignant glioma     Lung cancer     Leukemia     Carcinoma
    Heart disease     Hyperglycemia     Hepatocellular carcinoma     Colorectal cancer
    Ovarian cancer     Melanoma     Pancreatic cancer     Lymphoma
    Brain disease     Neuroblastoma     Alzheimer's disease     Retinoblastoma

    10/84 Novoseek disease relationships for AKT1 gene (see all 84)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 53.2 97 11571628 (5), 19216065 (3), 19876913 (3), 17611497 (3) (see all 66)
    insulin resistance 47.2 15 15634339 (2), 10373517 (1), 20101593 (1), 11274905 (1) (see all 14)
    wiskott-aldrich syndrome 47.1 7 15657136 (1), 10488099 (1), 18198193 (1), 11580754 (1) (see all 7)
    tumors 45 142 17027002 (4), 12191616 (4), 11593437 (4), 17639041 (4) (see all 80)
    glioblastoma 36.1 7 10958682 (2), 11439092 (1), 18250332 (1), 19234490 (1) (see all 5)
    breast cancer 34.4 50 16782806 (5), 16711509 (3), 18087195 (3), 16428439 (3) (see all 30)
    thymoma 29.8 12 16251502 (1), 15522255 (1), 17464696 (1), 17611497 (1) (see all 10)
    metastasis 27.4 17 19305425 (2), 15886842 (2), 19487299 (1), 20360004 (1) (see all 13)
    insulin sensitivity 27.2 2 18599621 (1), 18573875 (1)
    hyperinsulinemia 22.8 1 17513702 (1)

    Genetic Association Database (GAD): AKT1
    Human Genome Epidemiology (HuGE) Navigator: AKT1 (87 documents)
    Tumor Gene Database (TGDB): AKT1

    Export disorders for AKT1 gene to outside databases

    Publications
    for AKT1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AKT1 gene, integrated from 9 sources (see all 2934) (see top 10):
    (articles sorted by number of sources associating them with AKT1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes. (PubMed id 11508278)1, 2, 4, 9 Matsubara A....Permutt M.A. (2001)
    2. Association of AKT1 with schizophrenia confirmed in a Japanese population. (PubMed id 15522255)1, 4, 9 Ikeda M....Ozaki N. (2004)
    3. The actin-bundling protein palladin is an Akt1-specif ic substrate that regulates breast cancer cell migration. (PubMed id 20471940)1, 2, 9 Chin Y.R. and Toker A. (2010)
    4. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. (PubMed id 17611497)1, 2, 9 Carpten J.D.... Thomas J.E. (2007)
    5. The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. (PubMed id 17932490)1, 2, 9 Cinar B....Freeman M.R. (2007)
    6. Kinetic mechanism of AKT/PKB enzyme family. (PubMed id 16540465)1, 2, 9 Zhang X....Kendall R.L. (2006)
    7. Cotreatment with a novel phosphoinositide analogue inhibitor and carmustine enhances chemotherapeutic efficacy by attenuating AKT activity in gliomas. (PubMed id 17041888)1, 7, 9 Van Meter T.E....Fillmore H. (2006)
    8. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PubMed id 15718470)1, 2, 9 Sarbassov D.D.... Sabatini D.M. (2005)
    9. PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. (PubMed id 14761976)1, 2, 9 Ahn J.-Y.... Ye K. (2004)
    10. High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate. (PubMed id 12176338)1, 2, 9 Thomas C.C....van Aalten D.M. (2002)
    11. CREB is a regulatory target for the protein kinase Akt/PKB. (PubMed id 9829964)1, 2, 9 Du K. and Montminy M. (1998)
    12. A mosaic activating mutation in AKT1 associated with the Proteus syndrome. (PubMed id 21793738)1, 2 Lindhurst M.J.... Biesecker L.G. (2011)
    13. The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy. (PubMed id 21775285)1, 2 Sundaresan N.R.... Gupta M.P. (2011)
    14. Ret finger protein 2 enhances ionizing radiation-indu ced apoptosis via degradation of AKT and MDM2. (PubMed id 21333377)1, 2 Joo H.M....Jin Y.W. (2011)
    15. Akt1 and Akt2: differentiating the aktion. (PubMed id 21432781)1, 2 Heron-Milhavet L....Lamb N.J. (2011)
    16. Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120. (PubMed id 19940129)1, 2 Yuan Z....Cheng J.Q. (2010)
    17. Ack1 mediated AKT/PKB tyrosine 176 phosphorylation re gulates its activation. (PubMed id 20333297)1, 2 Mahajan K....Mahajan N.P. (2010)
    18. Phosphorylation of CLK2 at serine 34 and threonine 12 7 by AKT controls cell survival after ionizing radiation. (PubMed id 20682768)1, 2 Nam S.Y....Jin Y.W. (2010)
    19. Proapoptotic kinase MST2 coordinates signaling crosst alk between RASSF1A, Raf-1, and Akt. (PubMed id 20086174)1, 2 Romano D....Kolch W. (2010)
    20. Crystal structure of human AKT1 with an allosteric in hibitor reveals a new mode of kinase inhibition. (PubMed id 20886116)1, 2 Wu W.I....Brandhuber B.J. (2010)
    21. Regulation of proapoptotic mammalian ste20-like kinas e MST2 by the IGF1-Akt pathway. (PubMed id 20231902)1, 2 Kim D....Cheng J.Q. (2010)
    22. A novel human dynactin-associated protein, dynAP, pro motes activation of Akt, and ergosterol-related compounds induce dynAP-dependen t apoptosis of human cancer cells. (PubMed id 20978158)1, 2 Kunoh T....Mizukami T. (2010)
    23. The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. (PubMed id 20059950)1, 2 Suizu F.... Noguchi M. (2009)
    24. Interaction of Akt-phosphorylated SRPK2 with 14-3-3 m ediates cell cycle and cell death in neurons. (PubMed id 19592491)1, 2 Jang S.W....Ye K. (2009)
    25. The Rho-family GEF Asef2 activates Rac to modulate ad hesion and actin dynamics and thereby regulate cell migration. (PubMed id 19934221)1, 2 Bristow J.M....Webb D.J. (2009)
    26. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. (PubMed id 19713527)1, 2 Yang W.-L.... Lin H.-K. (2009)
    27. Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain. (PubMed id 18954143)1, 2 Landgraf K.E....Falke J.J. (2008)
    28. Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation. (PubMed id 17726016)1, 2 Jang S.W....Ye K. (2007)
    29. Absence of significant associations between four AKT1 SNP markers and schizophrenia in the Taiwanese population. (PubMed id 16395129)1, 4 Liu Y.L....Hwu H.G. (2006)
    30. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    31. Positive association of AKT1 haplotype to Japanese methamphetamine use disorder. (PubMed id 15982448)1, 4 Ikeda M....Ozaki N. (2006)
    32. Akt/PKB regulates actin organization and cell motility via Girdin/APE. (PubMed id 16139227)1, 2 Enomoto A.... Takahashi M. (2005)
    33. Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. (PubMed id 14749367)1, 2 Remy I. and Michnick S.W. (2004)
    34. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    35. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    36. PIKE-A is amplified in human cancers and prevents apoptosis by up- regulating Akt. (PubMed id 15118108)1, 2 Ahn J.-Y.... Ye K. (2004)
    37. PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. (PubMed id 12244301)1, 2 Shin I....Arteaga C.L. (2002)
    38. A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. (PubMed id 11994271)1, 2 Kane S....Lienhard G.E. (2002)
    39. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)1, 2 Fujita N.... Tsuruo T. (2002)
    40. Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase. (PubMed id 12149249)1, 2 Conus N.M.... Pearson R.B. (2002)
    41. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. (PubMed id 12150915)1, 2 Manning B.D.... Cantley L.C. (2002)
    42. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. (PubMed id 11154276)1, 2 Kim A.H....Chao M.V. (2001)
    43. Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. (PubMed id 11598301)1, 2 Maira S.-M....Hemmings B.A. (2001)
    44. Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage. (PubMed id 10926925)1, 2 Koh H....Chung J. (2000)
    45. The protooncogene TCL1 is an Akt kinase coactivator. (PubMed id 10983986)1, 2 Laine J....Noguchi M. (2000)
    46. Phosphorylation and regulation of Raf by Akt (protein kinase B). (PubMed id 10576742)1, 2 Zimmermann S. and Moelling K. (1999)
    47. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. (PubMed id 9736715)1, 2 Delcommenne M.... Dedhar S. (1998)
    48. Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. (PubMed id 9512493)1, 2 Walker K.S.... Alessi D.R. (1998)
    49. Mechanism of activation of protein kinase B by insulin and IGF-1. (PubMed id 8978681)1, 2 Alessi D.R.... Hemmings B.A. (1996)
    50. Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. (PubMed id 1533586)1, 2 Coffer P.J. and Woodgett J.R. (1992)
    51. Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. (PubMed id 1851997)1, 2 Jones P.F.... Hemmings B.A. (1991)
    52. Molecular cloning and characterisation of a novel putative protein- serine kinase related to the cAMP-dependent and protein kinase C families. (PubMed id 1718748)1, 2 Coffer P.J. and Woodgett J.R. (1991)
    53. Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway. (PubMed id 16174774)1, 9 Park S....Cheng J.Q. (2005)
    54. Rapid activation of Rac GTPase in living cells by for ce is independent of Src. (PubMed id 19924282)1, 9 Poh Y.C....Wang N. (2009)
    55. Protein kinase Czeta is a negative regulator of protein kinase B activity. (PubMed id 10085094)1, 9 Doornbos R.P....van Bergen en Henegouwen P.M. (1999)
    56. Epistatic and functional interactions of catechol-o-m ethyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models. (PubMed id 20520724)1, 9 Sei Y....Weinberger D.R. (2010)
    57. AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families. (PubMed id 17825267)1, 9 Thiselton D.L....Riley B.P. (2008)
    58. Differential activation of CREB by Akt1 and Akt2. (PubMed id 17276404)1, 9 Kato S....Du K. (2007)
    59. Regulation of protein kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines. (PubMed id 16842970)1, 9 Sharrard R.M. and Maitland N.J. (2007)
    60. Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. (PubMed id 10716693)2, 9 Pekarsky Y.... Croce C.M. (2000)
    61. Association of polymorphisms in AKT1 and EGFR with cl inical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib. (PubMed id 20159991)1, 9 Giovannetti E....Tibaldi C. (2010)
    62. Genetic inactivation of AKT1, AKT2, and PDPK1 in huma n colorectal cancer cells clarifies their roles in tumor growth regulation. (PubMed id 20133737)1, 9 Ericson K....Papadopoulos N. (2010)
    63. PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity. (PubMed id 18249092)1, 9 Ma K....Duronio V. (2008)
    64. The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation. (PubMed id 17914025)1, 9 Yin H....Du X. (2008)
    65. AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway. (PubMed id 17616691)1, 9 Liu L.Z....Jiang B.H. (2007)
    66. Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells. (PubMed id 15888491)1, 9 Dihlmann S....von Knebel Doeberitz M. (2005)
    67. WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate. (PubMed id 14611643)1, 9 Vitari A.C....Alessi D.R. (2004)
    68. Scaffold proteins IRSp53 and spinophilin regulate loc alized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1) . (PubMed id 20360004)1, 9 Rajagopal S....Buchsbaum R.J. (2010)
    69. The oncogenic mutation in the pleckstrin homology dom ain of AKT1 in endometrial carcinomas. (PubMed id 19491896)1, 9 Shoji K....Taketani Y. (2009)
    70. Complex formation of p65/RelA with nuclear Akt1 for enhanced transcriptional activation of NF-kappaB. (PubMed id 18035048)1, 9 Kwon O....Kim B.Y. (2008)
    71. Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1. (PubMed id 17580302)1, 9 Dong B....Liu R. (2007)
    72. Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains. (PubMed id 17635910)1, 9 Cinar B....Freeman M.R. (2007)
    73. Dissociation of gemcitabine sensitivity and protein kinase B signaling in pancreatic ductal adenocarcinoma models. (PubMed id 17895832)1, 9 Pham N.A....Hedley D.W. (2007)
    74. Phosphatidylinositol 3-kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation. (PubMed id 17716861)1, 9 Sun L....Zha X. (2007)
    75. Involvement of insulin-like growth factor type 1 receptor and protein kinase Cdelta in bis(maltolato)oxovanadium(IV)-induced phosphorylation of protein kinase B in HepG2 cells. (PubMed id 16981720)1, 9 Mehdi M.Z....Srivastava A.K. (2006)
    76. Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. (PubMed id 16982699)2, 9 Heron-Milhavet L....Lamb N.J. (2006)
    77. Akt1 is dynamically modified with O-GlcNAc following treatments with PUGNAc and insulin-like growth factor-1. (PubMed id 16684529)1, 9 Gandy J.C....Bijur G.N. (2006)
    78. Reversal of multidrug resistance of gastric cancer cells by downregulation of Akt1 with Akt1 siRNA. (PubMed id 17310852)1, 9 Han Z....Fan D. (2006)
    79. Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop. (PubMed id 15998799)1, 9 Song J.J. and Lee Y.J. (2005)
    80. JNK-interacting protein 1 promotes Akt1 activation. (PubMed id 12783873)1, 9 Kim A.H....Chao M.V. (2003)
    81. Binding of protein kinase B to the plakin family member periplakin. (PubMed id 12244133)1, 9 van den Heuvel A.P.... Burgering B.M.T. (2002)
    82. Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI. (PubMed id 11825911)1, 9 Barry F.A. and Gibbins J.M. (2002)
    83. The PI3K-PDK1 connection: more than just a road to PKB. (PubMed id 10698680)1, 9 Vanhaesebroeck B. and Alessi D.R. (2000)
    84. Studies on the phosphorylation of protein kinase B by Ca(2+)/calmodulin-dependent protein kinases. (PubMed id 10833263)1, 9 Okuno S....Fujisawa H. (2000)
    85. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. (PubMed id 19164214)1, 9 Hildebrandt M.A....Wu X. (2009)
    86. Association of AKT1 gene polymorphisms with risk of schizophrenia and with response to antipsychotics in the Chinese population. (PubMed id 17915974)1, 9 Xu M.Q....He L. (2007)
    87. Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophrenia. (PubMed id 16987250)1, 9 Ide M....Yoshikawa T. (2006)
    88. Glucose uptake via glucose transporter 3 by human platelets is regulated by protein kinase B. (PubMed id 16049004)1, 9 Ferreira I.A....Akkerman J.W. (2005)
    89. R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho. (PubMed id 15525681)1, 9 Wozniak M.A....Keely P.J. (2005)
    90. Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sib-pair families. (PubMed id 16026766)1, 9 Schwab S.G....Wildenauer D.B. (2005)
    91. Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. (PubMed id 14560023)1, 9 Powell D.J....Hundal H.S. (2003)
    92. Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH. (PubMed id 20102399)1, 9 Kirkegaard T....Bartlett J.M. (2010)
    93. Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylino sitol 3 kinase. (PubMed id 20361045)1, 9 Ding Z....Mills G.B. (2010)
    94. Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic ro les for BRAF, PIK3CA, and AKT1. (PubMed id 19487299)1, 9 Ricarte-Filho J.C....Fagin J.A. (2009)
    95. Suppression of Akt1 expression by small interference RNA inhibits SGC7901 cell growth in vitro and in vivo. (PubMed id 19885581)1, 9 Cui X.W....Zhang Q.Y. (2009)
    96. Associations between Notch-2, Akt-1 and HER2/neu expression in invasive human breast cancer: a tissue microarray immunophenotypic analysis on 98 patients. (PubMed id 18087195)1, 9 Florena A.M....Franco V. (2007)
    97. Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4. (PubMed id 16428439)1, 9 Yang C....Kazanietz M.G. (2006)
    98. Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression. (PubMed id 16775835)1, 9 Xia C....Jiang B.H. (2006)
    99. Arsenite induces endothelial cytotoxicity by down-regulation of vascular endothelial nitric oxide synthase. (PubMed id 16239170)7, 9 Tsou T.C....Chang L.W. (2005)
    100. Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors. (PubMed id 15545269)1, 9 Sugatani T. and Hruska K.A. (2005)
    101. Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix. (PubMed id 15306850)1, 9 Feng Q....Cerione R.A. (2004)
    102. Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1. (PubMed id 12529330)7, 9 He Z....Dong Z. (2003)
    103. Hotspot mutations of PIK3CA and AKT1 genes are absent in multiple myeloma. (PubMed id 20022634)1, 9 Ismail S.I....Sughayer M.A. (2010)
    104. Expression of Akt and Mdm2 in human esophageal squamo us cell carcinoma. (PubMed id 19124015)1, 9 Takahashi K....Tajiri T. (2009)
    105. AKT1 Gene Polymorphisms and Obstetric Complications i n the Patients with Schizophrenia. (PubMed id 20046382)1, 9 Joo E.J....Kim Y.S. (2009)
    106. Expression of p-Akt and COX-2 in gastric adenocarcino mas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric ad enocarcinoma and U251 glioma cell growth in vitro and in vivo. (PubMed id 19925030)1, 9 Zhang J....Kang C.S. (2009)
    107. AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51. (PubMed id 19010915)1, 9 Plo I....Lopez B.S. (2008)
    108. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. (PubMed id 18676830)1, 9 Stemke-Hale K....Hennessy B.T. (2008)
    109. The transforming mutation E17K/AKT1 is not a major event in B-cell-derived lymphoid leukaemias. (PubMed id 18665177)1, 9 Mahmoud I.S....Ismail S.I. (2008)
    110. Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors. (PubMed id 17804734)1, 9 O'Shaughnessy R.F....Byrne C. (2007)
    111. Role of receptor and nonreceptor protein tyrosine kinases in H2O2-induced PKB and ERK1/2 signaling. (PubMed id 17406055)1, 9 Mehdi M.Z....Srivastava A.K. (2007)
    112. Association of AKT1 haplotype with the risk of schizophrenia in Iranian population. (PubMed id 16583435)1, 9 Bajestan S.N....Osame M. (2006)
    113. Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch. (PubMed id 16651639)1, 9 Birukova A.A....Birukov K.G. (2006)
    114. Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588. (PubMed id 16141217)1, 9 Katsanakis K.D. and Pillay T.S. (2005)
    115. Regulation of protein kinase B tyrosine phosphorylation by thyroid-specific oncogenic RET/PTC kinases. (PubMed id 15994200)1, 9 Jung H.S....Shong M. (2005)
    116. Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes. (PubMed id 15833736)1, 9 Wijayanti N....Immenschuh S. (2005)
    117. Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. (PubMed id 12446767)1, 9 Ming X.F....Yang Z. (2002)
    118. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PubMed id 11707444)1, 9 Laine J.... Noguchi M. (2002)
    119. AKT1 polymorphisms are associated with tuberculosis i n the Chinese population. (PubMed id 20141546)1, 9 Wang X....Cheng X. (2010)
    120. AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K. (PubMed id 19802009)1, 9 Askham J.M....Knowles M.A. (2010)
    121. High prevalence of PIK3CA/AKT pathway mutations in pa pillary neoplasms of the breast. (PubMed id 19898424)1, 9 Troxell M.L....Corless C.L. (2010)
    122. Serotonin 1A receptor gene is associated with Japanes e methamphetamine-induced psychosis patients. (PubMed id 19747927)1, 9 Kishi T....Iwata N. (2010)
    123. Knock in of the AKT1 E17K mutation in human breast ep ithelial cells does not recapitulate oncogenic PIK3CA mutations. (PubMed id 20101210)1, 9 Lauring J....Park B.H. (2010)
    124. Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex. (PubMed id 20086095)1, 9 BjA...TaskAcn K. (2010)
    125. Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts. (PubMed id 20398329)1, 9 Wickenden J.A. and Watson C.J. (2010)
    126. Regulation of Akt signaling activation by ubiquitinat ion. (PubMed id 20081374)1, 9 Yang W.L....Lin H.K. (2010)
    127. Overcoming amino-Nogo-induced inhibition of cell spre ading and neurite outgrowth by 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters. (PubMed id 20018888)1, 9 Deng K....Walsh F.S. (2010)
    128. Functional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of beta-parvin. (PubMed id 20164304)1, 9 Kimura M....Kobayashi E. (2010)
    129. AKT1 pleckstrin homology domain E17K activating mutat ion in endometrial carcinoma. (PubMed id 19853286)1, 9 Cohen Y....Rechavi G. (2010)
    130. AKT1 E17 K pleckstrin homology domain mutation in urothelial carcinoma. (PubMed id 19389506)1, 9 Zilberman D.E....Rechavi G. (2009)
    131. PI3K/Akt pathway mutations in Retinoblastoma. (PubMed id 19420344)1, 9 Cohen Y....Goldenberg-Cohen N. (2009)
    132. Expression of selected tumor suppressor and oncogenes in endometrium of women with endometriosis. (PubMed id 19429661)1, 9 Laudanski P....Chyczewski L. (2009)
    133. Activation-induced Degradation of FLIPL Is Mediated via the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Macrophages. (PubMed id 19339247)1, 9 Shi B....Pope R.M. (2009)
    134. Inhibitory effects of adenovirus mediated COX-2, Akt1 and PIK3R1 shRNA on the growth of malignant tumor cells in vitro and in vivo. (PubMed id 19639178)1, 9 Fu Y....Wang T. (2009)
    135. Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma. (PubMed id 19418217)1, 9 Dunlap J....Troxell M.L. (2009)
    136. Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice. (PubMed id 18668138)1, 9 Goren I....Frank S. (2009)
    137. Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses. (PubMed id 18048359)1, 9 Altman J.K....Platanias L.C. (2008)
    138. Lack of association between AKT1 variances versus clinical manifestations and social function in patients with schizophrenia. (PubMed id 18635704)1, 9 Liu Y.C....Lane H.Y. (2008)
    139. AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition. (PubMed id 18413665)1, 9 Caporali S....D'Atri S. (2008)
    140. VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation. (PubMed id 18332868)1, 9 Huang J. and Chen J. (2008)
    141. Characterization of Akt overexpression in MiaPaCa-2 cells: prohibitin is an Akt substrate both in vitro and in cells. (PubMed id 18507042)2, 9 Han E.K....Luo Y. (2008)
    142. AKT1 (E17K) mutation in pancreatic cancer. (PubMed id 18783292)1, 9 Mohamedali A....Kocher H.M. (2008)
    143. Overexpression of Akt1 upregulates glycogen synthase activity and phosphorylation of mTOR in IRS-1 knockdown HepG2 cells. (PubMed id 17721885)1, 9 Varma S. and Khandelwal R.L. (2008)
    144. Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent. (PubMed id 18332138)1, 9 Litherland G.J....Rowan A.D. (2008)
    145. The potential role of Akt phosphorylation in human cancers. (PubMed id 18409144)1, 9 Cicenas J. (2008)
    146. Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting. (PubMed id 18611285)1, 9 Do H....Dobrovic A. (2008)
    147. Association of a Nonsynonymous Variant of DAOA with Visuospatial Ability in a Bipolar Family Sample. (PubMed id 18466879)1, 9 Soronen P....Paunio T. (2008)
    148. Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair. (PubMed id 18644989)1, 9 Toulany M....Rodemann H.P. (2008)
    149. Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients. (PubMed id 18204829)1, 9 Cozzone D....Vidal H. (2008)
    150. Role of Akt isoforms in HGF-induced invasive growth of human salivary gland cancer cells. (PubMed id 18355439)1, 9 Hara S....Hamakawa H. (2008)
    151. Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids. (PubMed id 18676874)1, 9 Birukova A.A....Birukov K.G. (2008)
    152. Absence of E17K mutation in the pleckstrin homology domain of AKT1 in gastrointestinal and liver cancers in the Korean population. (PubMed id 18754328)1, 9 Cao Z....Park W.S. (2008)
    153. TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells. (PubMed id 19050243)1, 9 Bekeredjian-Ding I....Heeg K. (2008)
    154. Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia. (PubMed id 18855532)1, 9 Ikeda M....Iwata N. (2008)
    155. The Par6alpha/aPKC complex regulates Akt1 activity by phosphorylating Thr34 in the PH-domain. (PubMed id 17335965)1, 9 Weyrich P....Lammers R. (2007)
    156. Lysophosphatidylcholine mediates melanocyte dendricity through PKCzeta activation. (PubMed id 17024099)1, 9 Scott G.A....Jacobs S.E. (2007)
    157. Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression. (PubMed id 17577629)1, 9 Gao H....Ma R. (2007)
    158. P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. (PubMed id 17565979)1, 9 Hernandez-Negrete I....Vazquez-Prado J. (2007)
    159. Regulation of the pro-apoptotic scaffolding protein POSH by Akt. (PubMed id 17535800)1, 9 Lyons T.R....Kassenbrock C.K. (2007)
    160. Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor-alpha activity. (PubMed id 17505062)1, 9 Ma Y....Rosen E.M. (2007)
    161. Investigation of interleukin 1beta-mediated regulation of NF-kappaB activation in colonic cells reveals divergence between PKB and PDK-transduced events. (PubMed id 17136479)1, 9 Parhar K....Salh B. (2007)
    162. Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses. (PubMed id 17925406)1, 9 Jensen M....Urso B. (2007)
    163. Real-time imaging nuclear translocation of Akt1 in HCC cells. (PubMed id 17400190)1, 9 Zhu L....Gu J. (2007)
    164. FGFR1 over-expression in primary rhabdomyosarcoma tumors is associated with hypomethylation of a 5' CpG island and abnormal expression of the AKT1, NOG, and BMP4 genes. (PubMed id 17696196)1, 9 Goldstein M....Orr-Urtreger A. (2007)
    165. Following the tracks of AKT1 gene. (PubMed id 17921701)1, 9 Vogiatzi P. and Giordano A. (2007)
    166. Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160. (PubMed id 17513702)1, 9 Frosig C....Wojtaszewski J.F. (2007)
    167. Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway. (PubMed id 17827393)1, 9 Hers I. (2007)
    168. Activated Akt signaling pathway in invasive ductal carcinoma of the breast: correlation with HER2 overexpression. (PubMed id 17549359)1, 9 Park S.S. and Kim S.W. (2007)
    169. Expression of caveolin-1 is correlated with Akt-1 in colorectal cancer tissues. (PubMed id 16202996)1, 9 Kim H.A....Lee R.A. (2006)
    170. Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway. (PubMed id 16839745)1, 9 Meng Q....Jiang B.H. (2006)
    171. Tryptase activates PKB in inflammatory reaction in ECV304 cells. (PubMed id 16564100)1, 9 Ma Y....Yin L. (2006)
    172. Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway. (PubMed id 16849522)1, 9 Pore N....Maity A. (2006)
    173. Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients. (PubMed id 16049961)1, 9 Tokunaga E....Maehara Y. (2006)
    174. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. (PubMed id 16537497)1, 9 Liu H....Bissell M.J. (2006)
    175. CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12. (PubMed id 16114056)1, 9 Chinni S.R....Cher M.L. (2006)
    176. Hypoxia-inducible factor-1alpha expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas. (PubMed id 16682946)1, 9 Gort E.H....Shvarts A. (2006)
    177. Protein kinase B inhibits endostatin-induced apoptosis in HUVECs. (PubMed id 16466644)1, 9 Kang H.Y....Kim H.Y. (2006)
    178. Akt1 contains a functional leucine-rich nuclear export sequence. (PubMed id 15896313)1, 9 Saji M....Ringel M.D. (2005)
    179. Thyroid hormone induces rapid activation of Akt/protein kinase B-mammalian target of rapamycin-p70S6K cascade through phosphatidylinositol 3-kinase in human fibroblasts. (PubMed id 15388791)1, 9 Cao X....Seo H. (2005)
    180. Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. (PubMed id 15806160)1, 9 Sutherland B.W.... Dunn S.E. (2005)
    181. Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120. (PubMed id 15689238)1, 9 Langford D....Masliah E. (2005)
    182. The role of Akt on arsenic trioxide suppression of 3T 3-L1 preadipocyte differentiation. (PubMed id 15916724)7, 9 Wang Z.X....Chen Q. (2005)
    183. Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators. (PubMed id 15911620)1, 9 Song J.J. and Lee Y.J. (2005)
    184. Albumin endocytosis in proximal tubule cells is modulated by angiotensin II through an AT2 receptor-mediated protein kinase B activation. (PubMed id 16293694)1, 9 Caruso-Neves C....Guggino W.B. (2005)
    185. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. (PubMed id 15808505)1, 9 Gao T.... Newton A.C. (2005)
    186. Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2. (PubMed id 15987444)1, 9 Cicenas J....Eppenberger-Castori S. (2005)
    187. Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation. (PubMed id 16266983)2, 9 Brandts C.H....Serve H. (2005)
    188. Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors. (PubMed id 15047604)1, 9 Kwon H.S....Harris R.A. (2004)
    189. AKT participates in endothelial dysfunction in hypertension. (PubMed id 15136501)1, 9 Iaccarino G....Trimarco B. (2004)
    190. Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration. (PubMed id 15149849)1, 9 Berven L.A....Crouch M.F. (2004)
    191. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). (PubMed id 14645242)1, 9 Dan H.C.... Cheng J.Q. (2004)
    192. Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes. (PubMed id 15010337)1, 9 Gosmanov A.R....Thomason D.B. (2004)
    193. The activity of the plexin-A1 receptor is regulated by Rac. (PubMed id 15187088)1, 9 Turner L.J....Hall A. (2004)
    194. Normal function of HERG K+ channels expressed in HEK293 cells requires basal protein kinase B activity. (PubMed id 12527373)1, 9 Zhang Y....Wang Z. (2003)
    195. Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation. (PubMed id 12592338)1, 9 Bortul R....Martelli A.M. (2003)
    196. Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. (PubMed id 12964941)2, 9 Milburn C.C....Van Aalten D.M. (2003)
    197. Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. (PubMed id 12458207)1, 9 Barthwal M.K....Rana A. (2003)
    198. Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1. (PubMed id 12176337)1, 9 Hill M.M....Hemmings B.A. (2002)
    199. Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. (PubMed id 12167664)1, 9 Dan H.C....Cheng J.Q. (2002)
    200. Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. (PubMed id 12167717)1, 9 Scheid M.P....Woodgett J.R. (2002)
    201. PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2. (PubMed id 11782427)1, 9 Lynch D.K. and Daly R.J. (2002)
    202. Insulin suppresses transactivation by CAAT/enhancer-binding proteins beta (C/EBPbeta). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPbeta. (PubMed id 11116148)1, 9 Guo S....Unterman T.G. (2001)
    203. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). (PubMed id 11154281)1, 9 Brunet A.... Greenberg M.E. (2001)
    204. Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3. (PubMed id 10491192)1, 9 Masure S.... Richardson A. (1999)
    205. Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function. (PubMed id 10497255)1, 9 Paz K....Zick Y. (1999)
    206. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. (PubMed id 10358075)2, 9 Rena G.... Cohen P. (1999)
    207. Role of translocation in the activation and function of protein kinase B. (PubMed id 9395488)1, 9 Andjelkovic M....Hemmings B.A. (1997)
    208. 3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. (PubMed id 9368760)1, 9 Alessi D.R.... Bownes M. (1997)
    209. Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216. (PubMed id 9373175)1, 9 Shaw M....Alessi D.R. (1997)
    210. Positive feedback regulation of heat shock protein 70 (Hsp70) is mediated through Toll-like receptor 4-PI3K/Akt-glycogen synthase kina se-3b pathway. (PubMed id 23043959)1 Lee K.H....Yoo C.G. (2013)
    211. The microRNA-302-367 cluster suppresses the proliferat ion of cervical carcinoma cells through the novel target AKT1. (PubMed id 23185040)1 Cai N....Zheng P.S. (2013)
    212. HuR inhibits apoptosis by amplifying Akt signaling thr ough a positive feedback loop. (PubMed id 22674407)1 Singh M....Lee B.S. (2013)
    213. Clinicopathological correlations of mTOR and pAkt expression in non-small cell lung cancer. (PubMed id 22562131)1 Oh M.H....Chung J.H. (2012)
    214. Molecular alterations in AKT and its protein activatio n in human lung carcinomas. (PubMed id 22748472)1 Dobashi Y....Ooi A. (2012)
    215. MEK inhibition leads to PI3K/AKT activation by relievi ng a negative feedback on ERBB receptors. (PubMed id 22552284)1 Turke A.B....Engelman J.A. (2012)
    216. Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling. (PubMed id 22629392)2 Wang S.... Geng M. (2012)
    217. JNK- and Akt-mediated Puma expression in the apoptosis of cisplatin-resistant ovarian cancer cells. (PubMed id 22394200)1 Zhao Z....Wei Y. (2012)
    218. ON 01910.Na is selectively cytotoxic for chronic lymph ocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhi bition and induction of oxidative stress. (PubMed id 22351695)1 Chapman C.M....Wiestner A. (2012)
    219. Overexpression of the /-opioid receptor in human non-s mall cell lung cancer promotes Akt and mTOR activation, tumor growth, and metast asis. (PubMed id 22343475)1 Lennon F.E....Singleton P.A. (2012)
    220. Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromoso me 10 to regulate phosphorylation of Akt kinase. (PubMed id 22184110)1 Das F....Choudhury G.G. (2012)
    221. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    222. High-resolution melting analysis as a sensitive prescr eening diagnostic tool to detect KRAS , BRAF , PIK3CA , and AKT1 mutations in fo rmalin-fixed, paraffin-embedded tissues. (PubMed id 22938585)1 Ney J.T....Merkelbach-Bruse S. (2012)
    223. Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-in duced autophagy in cancer cells. (PubMed id 22535956)1 Lo Re A.E....Fernandez-Zapico M.E. (2012)
    224. Silencing of ETV6/RUNX1 abrogates PI3K/AKT/mTOR signal ing and impairs reconstitution of leukemia in xenografts. (PubMed id 22094587)1 Fuka G....Panzer-Grumayer R. (2012)
    225. Redox modification of Akt mediated by the dopaminergic neurotoxin MPTP, in mouse midbrain, leads to down-regulation of pAkt. (PubMed id 22198382)1 Durgadoss L....Ravindranath V. (2012)
    226. Effect of phosphatase and tensin homology deleted on c hromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K56 2/ADM cells. (PubMed id 22185283)1 Cheng Z....Pan L. (2012)
    227. Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apo ptosis. (PubMed id 22768179)1 Hussain A.R....Uddin S. (2012)
    228. Threonine-120 phosphorylation regulated by phosphoinos itide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits th e antitumor activity of mammalian sterile 20-like kinase 1. (PubMed id 22619175)1 Collak F.K....Cinar B. (2012)
    229. Marked reduction of AKT1 expression and deregulation o f AKT1-associated pathways in peripheral blood mononuclear cells of schizophreni a patients. (PubMed id 22393424)1 van Beveren N.J....Elgersma Y. (2012)
    230. Transforming growth factor-b1 induces epithelial-to-me senchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 sign aling pathways. (PubMed id 21713404)1 Chen X.F....Wang H.Y. (2012)
    231. AKT signaling pathway activated by HIN-1 methylation i n non-small cell lung cancer. (PubMed id 22095135)1 Yu Y....Guo M. (2012)
    232. CD133 negatively regulates tumorigenicity via AKT path way in synovial sarcoma. (PubMed id 22571340)1 Kimura T....Tanaka S. (2012)
    233. The protein kinase Akt1 regulates the interferon respo nse through phosphorylation of the transcriptional repressor EMSY. (PubMed id 22315412)1 Ezell S.A....Tsichlis P.N. (2012)
    234. Erufosine suppresses breast cancer in vitro and in viv o for its activity on PI3K, c-Raf and Akt proteins. (PubMed id 22752602)1 Dineva I.K....Berger M.R. (2012)
    235. EGCG inhibits Tat-induced LTR transactivation: role of Nrf2, AKT, AMPK signaling pathway. (PubMed id 22480519)1 Zhang H.S....Ruan Z. (2012)
    236. Selective effects of PD-1 on Akt and Ras pathways regu late molecular components of the cell cycle and inhibit T cell proliferation. (PubMed id 22740686)1 Patsoukis N....Boussiotis V.A. (2012)
    237. Cyr61 induces IL-6 production by fibroblast-like synov iocytes promoting Th17 differentiation in rheumatoid arthritis. (PubMed id 22547695)1 Lin J....Li N. (2012)
    238. miR-122 regulates p53/Akt signalling and the chemother apy-induced apoptosis in cutaneous T-cell lymphoma. (PubMed id 22235305)1 Manfe V....Gniadecki R. (2012)
    239. Differential function of Akt1 and Akt2 in human adipoc ytes. (PubMed id 22480544)1 Fischer-Posovszky P....Wabitsch M. (2012)
    240. Epidermal growth factor receptor (EGFR)-mediated posit ive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells. (PubMed id 22117074)1 Nunes-Xavier C.E....Pulido R. (2012)
    241. FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer. (PubMed id 22590527)1 Hou J. and Wang L. (2012)
    242. Chronic modulation of AMP-Kinase, Akt and mTOR pathway s by ionizing radiation in human lung cancer xenografts. (PubMed id 22607554)1 Storozhuk Y....Tsakiridis T. (2012)
    243. A comprehensive immunohistochemical and molecular appr oach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma. (PubMed id 23107319)1 Korkolopoulou P....Saetta A.A. (2012)
    244. SPARC overexpression inhibits cell proliferation in ne uroblastoma and is partly mediated by tumor suppressor protein PTEN and AKT. (PubMed id 22567126)1 Bhoopathi P....Rao J.S. (2012)
    245. AKT1 loss correlates with episomal HPV16 in vulval int raepithelial neoplasia. (PubMed id 22685591)1 Ekeowa-Anderson A.L....O'Shaughnessy R.F. (2012)
    246. CXCR7 mediated Gia independent activation of ERK and A kt promotes cell survival and chemotaxis in T cells. (PubMed id 22070874)1 Kumar R....Luthra K. (2012)
    247. 18b-glycyrrhetinic acid induces apoptosis through modu lation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells. (PubMed id 21732363)1 Sharma G....Das P.K. (2012)
    248. XB130 mediates cancer cell proliferation and survival through multiple signaling events downstream of Akt. (PubMed id 22928011)1 Shiozaki A....Liu M. (2012)
    249. Distinct roles of AKT isoforms in regulating b1-integr in activity, migration, and invasion in prostate cancer. (PubMed id 22809628)1 Virtakoivu R....Ivaska J. (2012)
    250. Increased activation of the PI3K/AKT pathway compromis es decidualization of stromal cells from endometriosis. (PubMed id 22072736)1 Yin X....Kim J.J. (2012)
    251. Akt is negatively regulated by the MULAN E3 ligase. (PubMed id 22410793)1 Bae S....An S. (2012)
    252. Modulation of AKT activity is associated with reversi ble dormancy in ascites-derived epithelial ovarian cancer spheroids. (PubMed id 22045027)1 Correa R.J....Shepherd T.G. (2012)
    253. Roles of genetic variants in the PI3K and RAS/RAF path ways in susceptibility to endometrial cancer and clinical outcomes. (PubMed id 22146979)1 Wang L.E....Mills G.B. (2012)
    254. The expression of phospho-AKT1 and phospho-MTOR is ass ociated with a favorable prognosis independent of PTEN expression in intrahepati c cholangiocarcinomas. (PubMed id 21874010)1 Lee D....Kim D.S. (2012)
    255. Expression of pERK and pAKT in pediatric high grade as trocytomas: correlation with YKL40 and prognostic significance. (PubMed id 21978279)1 Antonelli M....Giangaspero F. (2012)
    256. Activation of Akt is associated with poor prognosis an d chemotherapeutic resistance in pediatric B-precursor acute lymphoblastic leuke mia. (PubMed id 22183914)1 Morishita N....Morishima T. (2012)
    257. RNA interference of PARG could inhibit the metastatic potency of colon carcinoma cells via PI3-kinase/Akt pathway. (PubMed id 22508044)1 Li Q....Lazar A. (2012)
    258. EGFR and downstream genetic alterations in KRAS/BRAF a nd PI3K/AKT pathways in colorectal cancer: implications for targeted therapy. (PubMed id 23021375)1 Berg M. and Soreide K. (2012)
    259. Src, Akt, NF-kB, BCL-2 and c-IAP1 may be involved in a n anti-apoptotic effect in patients with BCR-ABL positive and BCR-ABL negative a cute lymphoblastic leukemia. (PubMed id 22591684)1 Vazquez-Franco J.E....Lezama R.A. (2012)
    260. AKT1 polymorphisms and survival of early stage non-sm all cell lung cancer. (PubMed id 21842521)1 Kim M.J....Park J.Y. (2012)
    261. Akt activation is responsible for enhanced migratory a nd invasive behavior of arsenic-transformed human bronchial epithelial cells. (PubMed id 21954225)1 Wang Z....Yang C. (2012)
    262. Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implic ations for drug design and development. (PubMed id 22391209)1 Caracciolo V....Giordano A. (2012)
    263. Insulin fails to enhance mTOR phosphorylation, mitocho ndrial protein synthesis, and ATP production in human skeletal muscle without am ino acid replacement. (PubMed id 22967500)1 Barazzoni R....Nair K.S. (2012)
    264. GUCY2C opposes systemic genotoxic tumorigenesis by reg ulating AKT-dependent intestinal barrier integrity. (PubMed id 22384056)1 Lin J.E....Waldman S.A. (2012)
    265. Nuclear import of hTERT requires a bipartite nuclear l ocalization signal and Akt-mediated phosphorylation. (PubMed id 22366458)1 Chung J....Chung I.K. (2012)
    266. Differential effects of AKT1(p.E17K) expression on hum an mammary luminal epithelial and myoepithelial cells. (PubMed id 22505016)1 Salhia B....Carpten J. (2012)
    267. Amplified in breast cancer 1 enhances human cholangioc arcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 p athways. (PubMed id 22213475)1 Chen Q....Li W. (2012)
    268. Genomic complexity and AKT dependence in serous ovaria n cancer. (PubMed id 22328975)1 Hanrahan A.J....Solit D.B. (2012)
    269. The miRNA-17?192 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. (PubMed id 22116552)1 Rao E....Fu K. (2012)
    270. Requirement of transmembrane domain for CD154 associat ion to lipid rafts and subsequent biological events. (PubMed id 22905203)1 Benslimane N....Mourad W. (2012)
    271. Genetic overlap between schizophrenia and bipolar diso rder: a study with AKT1 gene variants and clinical phenotypes. (PubMed id 22277669)1 Karege F....Schurhoff F. (2012)
    272. RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells. (PubMed id 22231444)1 Lin F.C....Lu P.J. (2012)
    273. CYLD negatively regulates transforming growth factor-b -signalling via deubiquitinating Akt. (PubMed id 22491319)1 Lim J.H....Li J.D. (2012)
    274. The Akt-SRPK-SR axis constitutes a major pathway in tr ansducing EGF signaling to regulate alternative splicing in the nucleus. (PubMed id 22727668)1 Zhou Z....Fu X.D. (2012)
    275. CaM kinase control of AKT and LNCaP cell survival. (PubMed id 22173970)1 Schmitt J.M....Fletcher L. (2012)
    276. Proximity ligation assays for isoform-specific Akt act ivation in breast cancer identify activated Akt1 as a driver of progression. (PubMed id 22430898)1 Spears M....Bartlett J.M. (2012)
    277. PTEN-mediated AKT activation contributes to the reduce d apoptosis among Indian oral squamous cell carcinoma patients. (PubMed id 22033727)1 Alyasiri N.S....Rizvi M.M. (2012)
    278. CXCL8 enhances proliferation and growth and reduces ap optosis in endometrial stromal cells in an autocrine manner via a CXCR1-triggere d PTEN/AKT signal pathway. (PubMed id 22563025)1 Li M.Q....Li D.J. (2012)
    279. Long isoform of ErbB3 binding protein, p48, mediates protein kinase B/Akt-dependent HDM2 stabilization and nuclear localization. (PubMed id 21930127)1 Kim C.K....Ahn J.Y. (2012)
    280. Diverse regulation of AKT and GSK-3b by O-GlcNAcylatio n in various types of cells. (PubMed id 22687243)1 Shi J....Gong C.X. (2012)
    281. Protein kinase G and focal adhesion kinase converge on Src/Akt/b-catenin signaling module in osteoblast mechanotransduction. (PubMed id 22563076)1 Rangaswami H....Pilz R.B. (2012)
    282. [Expression and significance of p-AKT, p-GSK3b and b-c atenin in epithelial carcinoma of ovary]. (PubMed id 22455883)1 Wei X....Cao C.C. (2012)
    283. Receptor-specific mechanisms regulate phosphorylation of AKT at Ser473: role of RICTOR in b1 integrin-mediated cell survival. (PubMed id 22384145)1 Riaz A....Johansson S. (2012)
    284. Alteration in methylation pattern of oncogene Akt1 pro moter region in bladder cancer. (PubMed id 22189542)1 Sun X.F....Shen W. (2012)
    285. Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. (PubMed id 23112296)1 Wang R.C....Levine B. (2012)
    286. NAMPT (visfatin) and AKT1 genetic variants associate w ith myocardial infarction. (PubMed id 22251423)1 Leander K....Hogberg J. (2012)
    287. Promotion of the induction of cell pluripotency throug h metabolic remodeling by thyroid hormone triiodothyronine-activated PI3K/AKT si gnal pathway. (PubMed id 22575839)1 Chen M....Li T. (2012)
    288. Epstein-Barr virus latent membrane protein-1 protects B-cell lymphoma from rituximab-induced apoptosis through miR-155-mediated Akt ac tivation and up-regulation of Mcl-1. (PubMed id 22268450)1 Kim J.H....Park C. (2012)
    289. Mutations in FGFR3 and PIK3CA, singly or combined with RAS and AKT1, are associated with AKT but not with MAPK pathway activation in u rothelial bladder cancer. (PubMed id 22417847)1 Juanpere N....Hernandez S. (2012)
    290. Disruption of PH-kinase domain interactions leads to o ncogenic activation of AKT in human cancers. (PubMed id 23134728)1 Parikh C....Seshagiri S. (2012)
    291. Identification of Akt interaction protein PHF20/TZP th at transcriptionally regulates p53. (PubMed id 22334668)1 Park S....Cheng J.Q. (2012)
    292. Genetic variants in the PI3K/PTEN/AKT/mTOR pathway pre dict platinum-based chemotherapy response of advanced non-small cell lung cancer s in a Chinese population. (PubMed id 22901187)1 Xu J.L....Shu Y.Q. (2012)
    293. Transient activation of the PI3K-AKT pathway by hepati tis C virus to enhance viral entry. (PubMed id 23095753)1 Liu Z....Ou J.H. (2012)
    294. Cyclin G1-mediated epithelial-mesenchymal transition v ia phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression. (PubMed id 22271581)1 Wen W....Wang H. (2012)
    295. Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway. (PubMed id 22301279)1 Kong L....Klocker H. (2012)
    296. Differential expression of gastric MUC5AC in colonic e pithelial cells: TFF3-wired IL1 b/Akt crosstalk-induced mucosal immune response against Shigella dysenteriae infection. (PubMed id 22389405)1 Raja S.B....Devaraj S.N. (2012)
    297. Leptin-induced epithelial-mesenchymal transition in br east cancer cells requires b-catenin activation via Akt/GSK3- and MTA1/Wnt1 prot ein-dependent pathways. (PubMed id 22270359)1 Yan D....Sharma D. (2012)
    298. Role of PRAS40 in Akt and mTOR signaling in health and disease. (PubMed id 22354785)1 Wiza C....Ouwens D.M. (2012)
    299. The Akt/mammalian target of rapamycin pathway is activ ated and associated with adverse prognosis in soft tissue leiomyosarcomas. (PubMed id 21837670)1 Setsu N....Oda Y. (2012)
    300. Altered AKT1 and MAPK1 gene expression on peripheral b lood mononuclear cells and correlation with T-helper-transcription factors in sy stemic lupus erythematosus patients. (PubMed id 23125486)1 Garcia-Rodriguez S....Zubiaur M. (2012)
    301. Activation of AKT is associated with metastasis of na sopharyngeal carcinoma. (PubMed id 22116667)1 Liu Y....Guan J. (2012)
    302. USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-b type I receptor. (PubMed id 22706160)1 Zhang L....ten Dijke P. (2012)
    303. Targeting PI3 kinase/AKT/mTOR signaling in cancer. (PubMed id 22471665)1 Sheppard K....Phillips W.A. (2012)
    304. Hyperphosphorylation of Tau induced by naturally secre ted amyloid-b at nanomolar concentrations is modulated by insulin-dependent Akt- GSK3b signaling pathway. (PubMed id 22910909)1 Tokutake T....Ikeuchi T. (2012)
    305. Increased apoptosis in human knee osteoarthritis carti lage related to the expression of protein kinase B and protein kinase C&#945 ; in chondrocytes. (PubMed id 22532149)1 Chen Q....Xia C. (2012)
    306. Akt augments the oncogenic potential of the HBx protei n of hepatitis B virus by phosphorylation. (PubMed id 22309289)1 Khattar E....Kumar V. (2012)
    307. Endothelial derived factors inhibit anoikis of head an d neck cancer stem cells. (PubMed id 22014666)1 Campos M.S....Nor J.E. (2012)
    308. USP1 regulates AKT phosphorylation by modulating the s tability of PHLPP1 in lung cancer cells. (PubMed id 22426999)1 Zhiqiang Z....Yuepeng G. (2012)
    309. CXCL12/CXCR4 protein signaling axis induces sonic hedg ehog expression in pancreatic cancer cells via extracellular regulated kinase- a nd Akt kinase-mediated activation of nuclear factor kB: implications for bidirec tional tumor-stromal interactions. (PubMed id 22995914)1 Singh A.P....Singh S. (2012)
    310. The novel Akt inhibitor API-1 induces c-FLIP degradati on and synergizes with TRAIL to augment apoptosis independent of Akt inhibition. (PubMed id 22345097)1 Li B....Sun S.Y. (2012)
    311. A phytoestrogen diarylheptanoid mediates estrogen rece ptor/Akt/glycogen synthase kinase 3b protein-dependent activation of the Wnt/b-c atenin signaling pathway. (PubMed id 22936801)1 Bhukhai K....Chairoungdua A. (2012)
    312. AKT-mediated regulation of polarization in differentia ted human neutrophil-like HL-60 cells. (PubMed id 22588279)1 Zou W....Zou F. (2012)
    313. Exogenous and autocrine growth factors stimulate human intervertebral disc cell proliferation via the ERK and Akt pathways. (PubMed id 22105580)1 Pratsinis H....Kletsas D. (2012)
    314. PHF19 and Akt control the switch between proliferative and invasive states in melanoma. (PubMed id 22487681)1 Ghislin S....Alcaide-Loridan C. (2012)
    315. PTEN protein phosphatase activity correlates with cont rol of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity. (PubMed id 22375056)1 Tibarewal P....Leslie N.R. (2012)
    316. Simultaneous modulation of COX-2, p300, Akt, and Apaf- 1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells. (PubMed id 22335196)1 Wang J....Deng W. (2012)
    317. Hedgehog signaling is a novel therapeutic target in ta moxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway. (PubMed id 22875023)1 Ramaswamy B....Majumder S. (2012)
    318. 14-3-3s regulation by p53 mediates a chemotherapy resp onse to 5-fluorouracil in MCF-7 breast cancer cells via Akt inactivation. (PubMed id 22192357)1 Zheng G....He Z. (2012)
    319. Activation of the PI3K/AKT pathway in Merkel cell carc inoma. (PubMed id 22363598)1 Hafner C....Becker J.C. (2012)
    320. Effective connectivity of AKT1-mediated dopaminergic w orking memory networks and pharmacogenetics of anti-dopaminergic treatment. (PubMed id 22525159)1 Tan H.Y....Weinberger D.R. (2012)
    321. Multiple site acetylation of Rictor stimulates mammali an target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt prote in. (PubMed id 22084251)1 Glidden E.J....Mayo M.W. (2012)
    322. Overexpression of hyaluronan-binding protein 1 (HABP1/ p32/gC1qR) in HepG2 cells leads to increased hyaluronan synthesis and cell proli feration by up-regulation of cyclin D1 in AKT-dependent pathway. (PubMed id 22451658)1 Kaul R....Datta K. (2012)
    323. RGD-peptide lunasin inhibits Akt-mediated NF-kB activa tion in human macrophages through interaction with the aVb3 integrin. (PubMed id 22945510)1 Cam A. and de Mejia E.G. (2012)
    324. Synemin promotes AKT-dependent glioblastoma cell proli feration by antagonizing PP2A. (PubMed id 22337773)1 Pitre A....Skalli O. (2012)
    325. Integrin a5b1 simultaneously controls EGFR-dependent p roliferation and Akt-dependent pro-survival signaling in epidermoid carcinoma ce lls. (PubMed id 22626691)1 Morozevich G.E....Berman A.E. (2012)
    326. Notch1 promotes glioma cell migration and invasion by stimulating b-catenin and NF-kB signaling via AKT activation. (PubMed id 22093097)1 Zhang X....Ge J. (2012)
    327. IL-22 induced cell proliferation is regulated by PI3K/ Akt/mTOR signaling cascade. (PubMed id 22840496)1 Mitra A....Raychaudhuri S.P. (2012)
    328. HIV-1 matrix protein p17 promotes angiogenesis via che mokine receptors CXCR1 and CXCR2. (PubMed id 22904195)1 Caccuri F....Caruso A. (2012)
    329. CD40 stimulation induces vincristine resistance via AK T activation and MRP1 expression in a human multiple myeloma cell line. (PubMed id 22445357)1 Lee S.W....Choi I. (2012)
    330. Fascin, a novel marker of human hepatic stellate cell s, may regulate their proliferation, migration, and collagen gene expression th rough the FAK-PI3K-Akt pathway. (PubMed id 22005766)1 Uyama N....Fujimoto J. (2012)
    331. Long non-coding RNA UCA1 regulated cell cycle distribu tion via CREB through PI3-K dependent pathway in bladder carcinoma cells. (PubMed id 22285928)1 Yang C....Chen W. (2012)
    332. A conserved role of IQGAP1 in regulating TOR complex 1 . (PubMed id 22328503)1 Tekletsadik Y.K....Osman M.A. (2012)
    333. Akt and ERK control the proliferative response of mamm ary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2. (PubMed id 22394561)1 Worster D.T....Albeck J.G. (2012)
    334. PDGF enhances store-operated Ca2+ entry by upregulatin g STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth musc le cells. (PubMed id 22031597)1 Ogawa A....Yuan J.X. (2012)
    335. Grape proanthocyanidin inhibit pancreatic cancer cell growth in vitro and in vivo through induction of apoptosis and by targeting the PI3K/Akt pathway. (PubMed id 22905202)1 Prasad R....Katiyar S.K. (2012)
    336. Akt1 deficiency in schizophrenia and impairment of hip pocampal plasticity and function. (PubMed id 21049487)1 Balu D.T....Lucki I. (2012)
    337. Hepatocyte growth factor increases osteopontin express ion in human osteoblasts through PI3K, Akt, c-Src, and AP-1 signaling pathway. (PubMed id 22675553)1 Chen H.T....Tang C.H. (2012)
    338. Mucinous breast carcinomas lack PIK3CA and AKT1 mutati ons. (PubMed id 22705004)1 Kehr E.L....Troxell M.L. (2012)
    339. MicroRNA-7 inhibits tumor growth and metastasis by tar geting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma. (PubMed id 22234835)1 Fang Y....Tian L. (2012)
    340. Reciprocal regulation of Akt and Oct4 promotes the sel f-renewal and survival of embryonal carcinoma cells. (PubMed id 23041284)1 Lin Y....Wang Y.J. (2012)
    341. Integrin b1 mediates vaccinia virus entry through acti vation of PI3K/Akt signaling. (PubMed id 22496232)1 Izmailyan R....Chang W. (2012)
    342. HT-29 human colon cancer cell proliferation is regulat ed by cytosolic phospholipase A(2)a dependent PGE(2)via both PKA and PKB pathway s. (PubMed id 22728329)1 Kisslov L....Levy R. (2012)
    343. EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex. (PubMed id 22314363)1 Li G....Xie D. (2012)
    344. Involvement of microRNA-93, a new regulator of PTEN/Ak t signaling pathway, in regulation of chemotherapeutic drug cisplatin chemosensi tivity in ovarian cancer cells. (PubMed id 22465665)1 Fu X....Hao Q. (2012)
    345. Expression of podoplanin in human astrocytic brain tum ors is controlled by the PI3K-AKT-AP-1 signaling pathway and promoter methylatio n. (PubMed id 22394497)1 Peterziel H....Angel P. (2012)
    346. Selective modulation of subtype III IP_3R by Akt regul ates ER Ca^^+ release and apoptosis. (PubMed id 22552281)1 Marchi S....Pinton P. (2012)
    347. Activation of protein kinase B/Akt by alpha1-adrenocep tors in the human prostate. (PubMed id 22280833)1 Strittmatter F....Hennenberg M. (2012)
    348. Nitric oxide synthase and breast cancer: role of TIMP- 1 in NO-mediated Akt activation. (PubMed id 22957045)1 Ridnour L.A....Wink D.A. (2012)
    349. GATA2 negatively regulates PTEN by preventing nuclear translocation of androgen receptor and by androgen-independent suppression of PT EN transcription in breast cancer. (PubMed id 22021428)1 Wang Y....Eng C. (2012)
    350. Phosphorylated AKT protein is overexpressed in human p eripheral T-cell lymphomas and predicts decreased patient survival. (PubMed id 22297255)1 Cai Q....Lin T. (2012)
    351. Epstein-Barr virus latent membrane protein-2A induces ITAM/Syk- and Akt-dependent epithelial migration through av-integrin membrane tr anslocation. (PubMed id 22837212)1 Fotheringham J.A....Raab-Traub N. (2012)
    352. Knockdown of c-Met enhances sensitivity to bortezomib in human multiple myeloma U266 cells via inhibiting Akt/mTOR activity. (PubMed id 22339676)1 Que W....Jiang D. (2012)
    353. Pathobiological implications of the expression of EGFR , pAkt, NF-kB and MIC-1 in prostate cancer stem cells and their progenies. (PubMed id 22384099)1 Mimeault M....Batra S.K. (2012)
    354. Signaling networks associated with AKT activation in n on-small cell lung cancer (NSCLC): new insights on the role of phosphatydil-inos itol-3 kinase. (PubMed id 22363436)1 Scrima M....Viglietto G. (2012)
    355. Sp1 is involved in regulation of cystathionine g-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocell ular carcinoma cell lines. (PubMed id 22360859)1 Yin P....Zha X. (2012)
    356. Overexpression of the autoimmunity-associated phosphat ase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively acti vating AKT. (PubMed id 22569400)1 Negro R....Efremov D.G. (2012)
    357. Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model. (PubMed id 22952709)1 Loganathan S....Srivastava S.K. (2012)
    358. BMP signalling controls the malignant potential of asc ites-derived human epithelial ovarian cancer spheroids via AKT kinase activation . (PubMed id 22249415)1 Peart T.M....Shepherd T.G. (2012)
    359. VE-cadherin trans-interactions modulate Rac activation and enhancement of lung endothelial barrier by iloprost. (PubMed id 22213015)1 Birukova A.A....Birukov K.G. (2012)
    360. Akt, FoxO and regulation of apoptosis. (PubMed id 21440011)1 Zhang X....Rishi A.K. (2011)
    361. Caffeine modulates tau phosphorylation and affects Ak t signaling in postmitotic neurons. (PubMed id 20838929)1 Currais A....Soriano S. (2011)
    362. Akt/protein B and estradiol receptor alpha expression s in postmenopausal endometrium. (PubMed id 21295396)1 Wilhelm F....SzabA^ I. (2011)
    363. Nuclear translocation of epidermal growth factor rece ptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells. (PubMed id 21487020)1 Huang W.C....Hung M.C. (2011)
    364. Spatial relationship of phosphorylated epidermal growt h factor receptor and activated AKT in head and neck squamous cell carcinoma. (PubMed id 21775008)1 Nijkamp M.M....Kaanders J.H. (2011)
    365. PI3K/Akt signaling requires spatial compartmentalizat ion in plasma membrane microdomains. (PubMed id 21873248)1 Gao X....Zhang J. (2011)
    366. Angiopoietin-2, an angiogenic regulator, promotes ini tial growth and survival of breast cancer metastases to the lung through the in tegrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway. (PubMed id 21680733)1 Imanishi Y....Cheng S.Y. (2011)
    367. Activation of Akt/GSK3I^ and Akt/Bcl-2 signaling pathw ays in nickel-transformed BEAS-2B cells. (PubMed id 21837363)1 Pan J.J....Shi X. (2011)
    368. Scribble-mediated membrane targeting of PHLPP1 is req uired for its negative regulation of Akt. (PubMed id 21701506)1 Li X....Gao T. (2011)
    369. Akt phosphorylates and regulates the osteogenic activ ity of Osterix. (PubMed id 21777568)1 Choi Y.H....Lee K.Y. (2011)
    370. Myotubularin regulates Akt-dependent survival signali ng via phosphatidylinositol 3-phosphate. (PubMed id 21478156)1 Razidlo G.L....Taylor G.S. (2011)
    371. Dopaminergic pathway reconstruction by Akt/Rheb-induc ed axon regeneration. (PubMed id 21437936)1 Kim S.R....Burke R.E. (2011)
    372. The PKB/FOXO switch in aging and cancer. (PubMed id 21539865)1 Kloet D.E. and Burgering B.M. (2011)
    373. Hepatocyte growth factor inhibits anoikis of pancreat ic carcinoma cells through phosphatidylinositol 3-kinase pathway. (PubMed id 21499215)1 Watanabe S....Yokosuka O. (2011)
    374. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    375. Novel PI3K/Akt inhibitors screened by the cytoprotecti ve function of human immunodeficiency virus type 1 Tat. (PubMed id 21765914)1 Kim Y....Kim B. (2011)
    376. IkappaB kinase epsilon and TANK-binding kinase 1 acti vate AKT by direct phosphorylation. (PubMed id 21464307)1 Xie X....Guan K.L. (2011)
    377. Calcium-induced apoptosis is delayed by HER1 receptor signalling through the Akt and PLCI^ pathways in bladder cancer cells. (PubMed id 21087080)1 Memon A.A....Sorensen B.S. (2011)
    378. The phosphatidylinositol 3' kinase-Akt-mammalian targ et of rapamycin pathway in smooth muscle tumors of the uterus: selected protein expression patterns and their clinicopathologic implications. (PubMed id 21464729)1 Fadare O....Liang S.X. (2011)
    379. Chemokine CXCL12 uses CXCR4 and a signaling core form ed by bifunctional Akt, extracellular signal-regulated kinase (ERK)1/2, and mam malian target of rapamycin complex 1 (mTORC1) proteins to control chemotaxis an d survival simultaneously in mature dendritic cells. (PubMed id 21878648)1 Delgado-MartA-n C....RodrA-guez-FernA!ndez J.L. (2011)
    380. DNA-PK mediates AKT activation and apoptosis inhibitio n in clinically acquired platinum resistance. (PubMed id 22131882)1 Stronach E.A....Gabra H. (2011)
    381. Co-administration of perifosine with paclitaxel syner gistically induces apoptosis in ovarian cancer cells: more than just AKT inhibi tion. (PubMed id 21775054)1 Sun H....Li J. (2011)
    382. Mislocalization of the E3 ligase, I^-transducin repeat -containing protein 1 (I^-TrCP1), in glioblastoma uncouples negative feedback be tween the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt. (PubMed id 21454620)1 Warfel N.A....Newton A.C. (2011)
    383. Mild stretch activates cPLA2 in alveolar type II epit helial cells independently through the MEK/ERK and PI3K pathways. (PubMed id 21185392)1 Letsiou E....Lekka M.E. (2011)
    384. Genetic polymorphisms in inflammation pathway genes a nd prostate cancer risk. (PubMed id 21430300)1 Kwon E.M....Ostrander E.A. (2011)
    385. Targeting the Akt/mTOR pathway in Brca1-deficient can cers. (PubMed id 21242970)1 Xiang T....Yang Q. (2011)
    386. The tumor suppressor protein menin inhibits AKT activ ation by regulating its cellular localization. (PubMed id 21127195)1 Wang Y....Marx S.J. (2011)
    387. Resistance of Akt kinases to dephosphorylation throug h ATP-dependent conformational plasticity. (PubMed id 22031698)1 Chan T.O....Feldman A.M. (2011)
    388. The vanilloid capsaicin induces IL-6 secretion in pro state PC-3 cancer cells. (PubMed id 21474332)1 Malagarie-Cazenave S....DA-az-Laviada I. (2011)
    389. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    390. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    391. Downregulation of uPAR inhibits migration, invasion, proliferation, FAK/PI3K/Akt signaling and induces senescence in papillary thyro id carcinoma cells. (PubMed id 21191179)1 Nowicki T.S....Geliebter J. (2011)
    392. Ghrelin inhibits AGEs-induced apoptosis in human endo thelial cells involving ERK1/2 and PI3K/Akt pathways. (PubMed id 21370247)1 Xiang Y....Zhang J. (2011)
    393. Regulation of FoxO transcription factors by acetylati on and protein-protein interactions. (PubMed id 21396404)1 Daitoku H....Fukamizu A. (2011)
    394. Mitochondrial respiratory complex I dysfunction promot es tumorigenesis through ROS alteration and AKT activation. (PubMed id 21890492)1 Sharma L.K....Bai Y. (2011)
    395. Overexpression of MUC1 enhances proangiogenic activity of non-small-cell lung cancer cells through activation of Akt and extracellular signal-regulated kinase pathways. (PubMed id 21959954)1 Yao M....Cui B. (2011)
    396. mTORC2 protein complex-mediated Akt (Protein Kinase B ) Serine 473 Phosphorylation is not required for Akt1 activity in human platele ts [corrected]. (PubMed id 21592956)1 Moore S.F....Hers I. (2011)
    397. Overexpression of CREG attenuates atherosclerotic endo thelium apoptosis via VEGF/PI3K/AKT pathway. (PubMed id 21872252)1 Wang N....Yan C. (2011)
    398. Gq protein-induced apoptosis is mediated by AKT kinas e inhibition that leads to protein kinase C-induced c-Jun N-terminal kinase act ivation. (PubMed id 21757743)1 Ben-Ami I....Seger R. (2011)
    399. Akt cross-links IL-4 priming, stem cell factor signal ing, and IgE-dependent activation in mature human mast cells. (PubMed id 21106245)1 Feuser K....Lorentz A. (2011)
    400. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    401. Disruption of the interface between the pleckstrin ho mology (PH) and kinase domains of Akt protein is sufficient for hydrophobic mot if site phosphorylation in the absence of mTORC2. (PubMed id 21908613)1 Warfel N.A....Newton A.C. (2011)
    402. Human immunodeficiency virus type 1 induces lytic cycl e replication of Kaposi's-sarcoma-associated herpesvirus: role of Ras/c-Raf/MEK1 /2, PI3K/AKT, and NF-kB signaling pathways. (PubMed id 21763505)1 Zhu X....Lu C. (2011)
    403. Amino acids activate mammalian target of rapamycin co mplex 2 (mTORC2) via PI3K/Akt signaling. (PubMed id 21131356)1 Tato I....Rosa J.L. (2011)
    404. AP-1 regulates cyclin D1 and c-MYC transcription in a n AKT-dependent manner in response to mTOR inhibition: role of AIP4/Itch-mediat ed JUNB degradation. (PubMed id 21135252)1 Vartanian R....Gera J. (2011)
    405. Phosphomimetic substitution of heterogeneous nuclear ribonucleoprotein A1 at serine 199 abolishes AKT-dependent internal ribosome en try site-transacting factor (ITAF) function via effects on strand annealing and results in mammalian target of rapamycin complex 1 (mTORC1) inhibitor sensitiv ity. (PubMed id 21454539)1 Martin J....Gera J. (2011)
    406. Paradigm of kinase-driven pathway downstream of epide rmal growth factor receptor/Akt in human lung carcinomas. (PubMed id 21040950)1 Dobashi Y....Ooi A. (2011)
    407. Activation of PI3 kinase/Akt signaling in chronic subd ural hematoma outer membranes. (PubMed id 21309701)1 Funai M....Takayasu M. (2011)
    408. N-cadherin mediates angiogenesis by regulating monocy te chemoattractant protein-1 expression via PI3K/Akt signaling in prostate canc er cells. (PubMed id 21855541)1 Nalla A.K....Rao J.S. (2011)
    409. Phagocytosis of melanized Aspergillus conidia by macr ophages exerts cytoprotective effects by sustained PI3K/Akt signalling. (PubMed id 21501368)1 Volling K....Saluz H.P. (2011)
    410. Akt isoform-specific inhibition of MDA-MB-231 cell pr oliferation. (PubMed id 20688159)1 Yang W....Shin I. (2011)
    411. Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways. (PubMed id 22029423)1 Rashid A....Tsakiridis T. (2011)
    412. Regulation of IGF-1/PI3K/Akt signalling by the phosph oinositide phosphatase pharbin. (PubMed id 21436142)1 Wang F....Takenawa T. (2011)
    413. p28GANK overexpression accelerates hepatocellular car cinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-ind ucible factor-1I+ pathways. (PubMed id 21254169)1 Fu J....Wang H.Y. (2011)
    414. Dynamic regulation of GEF-H1 localization at microtub ules by Par1b/MARK2. (PubMed id 21513698)1 Yoshimura Y. and Miki H. (2011)
    415. Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells. (PubMed id 21405945)1 De Salvo M....Bucci B. (2011)
    416. MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors. (PubMed id 21394210)1 Clegg N.J....Sawyers C.L. (2011)
    417. [Significance of phosphoinositide 3 kinase/AKT pathway alterations in endometrial carcinoma]. (PubMed id 22336203)1 Yang X....Liao Q.P. (2011)
    418. Actin-independent exclusion of CD95 by PI3K/AKT signa lling: implications for apoptosis. (PubMed id 21557211)1 Pizon M....Legembre P. (2011)
    419. p16(INK4a) suppression by glucose restriction contrib utes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms. (PubMed id 21390332)1 Li Y. and Tollefsbol T.O. (2011)
    420. Beta-HPV 5 and 8 E6 promote p300 degradation by block ing AKT/p300 association. (PubMed id 21901101)1 Howie H.L....Galloway D.A. (2011)
    421. Disruption of PKB signaling restores polarity to cell s lacking tumor suppressor PTEN. (PubMed id 21169559)1 Tang M....Devreotes P. (2011)
    422. Asymmetric cancer cell division regulated by AKT. (PubMed id 21757645)1 Dey-Guha I....Ramaswamy S. (2011)
    423. E3 ubiquitin protein ligase, E6-associated protein (E 6-AP) regulates PI3K-Akt signaling and prostate cell growth. (PubMed id 20826237)1 Srinivasan S. and Nawaz Z. (2011)
    424. The E-box binding factors Max/Mnt, MITF, and USF1 act coordinately with FoxO to regulate expression of proapoptotic and cell cycle c ontrol genes by phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 si gnaling. (PubMed id 21873430)1 Terragni J....Cooper G.M. (2011)
    425. PKB/Akt promotes DSB repair in cancer cells through u pregulating Mre11 expression following ionizing radiation. (PubMed id 20956948)1 Deng R....Zhu X.F. (2011)
    426. A growth factor attenuates HIV-1 Tat and morphine indu ced damage to human neurons: implication in HIV/AIDS-drug abuse cases. (PubMed id 21483469)1 Malik S....Seth P. (2011)
    427. Inhibition of Akt (ser473) phosphorylation and rapamy cin-resistant cell growth by knockdown of mammalian target of rapamycin with sm all interfering RNA in vascular endothelial growth factor receptor-1-targeting vector. (PubMed id 21532145)1 Koide H....Oku N. (2011)
    428. Knockdown of STEAP4 inhibits insulin-stimulated gluco se transport and GLUT4 translocation via attenuated phosphorylation of Akt, ind ependent of the effects of EEA1. (PubMed id 21468601)1 Cheng R....Guo X.R. (2011)
    429. mTOR kinase inhibition causes feedback-dependent bipha sic regulation of AKT signaling. (PubMed id 22140653)1 Rodrik-Outmezguine V.S....Rosen N. (2011)
    430. Valproic acid induces monoamine oxidase A via Akt/for khead box O1 activation. (PubMed id 21775495)1 Wu J.B. and Shih J.C. (2011)
    431. Activation of I^-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like character s. (PubMed id 21284870)1 Li J. and Zhou B.P. (2011)
    432. Clusterin induces matrix metalloproteinase-9 expressi on via ERK1/2 and PI3K/Akt/NF-I_B pathways in monocytes/macrophages. (PubMed id 21742938)1 Shim Y.J....Min B.H. (2011)
    433. AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer. (PubMed id 21878679)1 Chan J.C....Pearson R.B. (2011)
    434. The mTOR/AKT inhibitor temsirolimus prevents deep infi ltrating endometriosis in mice. (PubMed id 21718677)1 Leconte M....Batteux F. (2011)
    435. On-off system for PI3-kinase-Akt signaling through S- nitrosylation of phosphatase with sequence homology to tensin (PTEN). (PubMed id 21646525)1 Numajiri N....Uehara T. (2011)
    436. AKT has an anti-apoptotic role in ABCA12-deficient ke ratinocytes. (PubMed id 21633372)1 Yanagi T....Shimizu H. (2011)
    437. CNK1 and other scaffolds for Akt/FoxO signaling. (PubMed id 21320536)1 Fritz R.D. and Radziwill G. (2011)
    438. FoxO transcription factors; Regulation by AKT and 14- 3-3 proteins. (PubMed id 21708191)1 Tzivion G....Ramakrishnan G. (2011)
    439. Omentin inhibits osteoblastic differentiation of calci fying vascular smooth muscle cells through the PI3K/Akt pathway. (PubMed id 21082206)1 Duan X.Y....Tang S.Y. (2011)
    440. The effect of leucine restriction on Akt/mTOR signali ng in breast cancer cell lines in vitro and in vivo. (PubMed id 21294052)1 Singh G....Meric-Bernstam F. (2011)
    441. OX40 complexes with phosphoinositide 3-kinase and pro tein kinase B (PKB) to augment TCR-dependent PKB signaling. (PubMed id 21289304)1 So T....Croft M. (2011)
    442. Angiopoietin-1/Tie2 signal augments basal Notch signa l controlling vascular quiescence by inducing delta-like 4 expression through A KT-mediated activation of beta-catenin. (PubMed id 21212269)1 Zhang J....Mochizuki N. (2011)
    443. [Expression and clinical significance of epidermal gro wth factor receptor and protein kinase B in gastric carcinoma]. (PubMed id 21365510)1 Zhang H.Y....Chen H.T. (2011)
    444. A switch toward angiostatic gene expression impairs t he angiogenic properties of endothelial progenitor cells in low birth weight preterm infants. (PubMed id 21659549)1 Ligi I....Anfosso F. (2011)
    445. ER stress inhibits mTORC2 and Akt signaling through G SK-3I^-mediated phosphorylation of rictor. (PubMed id 21343617)1 Chen C.H....Sarbassov d.o.s. .D. (2011)
    446. NADPH oxidase activation in pancreatic cancer cells i s mediated through Akt-dependent up-regulation of p22phox. (PubMed id 21118808)1 Edderkaoui M....Gukovskaya A.S. (2011)
    447. mTOR complex 2 targets Akt for proteasomal degradatio n via phosphorylation at the hydrophobic motif. (PubMed id 21321111)1 Wu Y.T....Su B. (2011)
    448. Deciphering the signaling pathways of cancer stem cel ls of glioblastoma multiforme: role of Akt/mTOR and MAPK pathways. (PubMed id 21035497)1 Jhanwar-Uniyal M....Murali R. (2011)
    449. Tissue microarray analysis of ezrin, KBA.62, CD166, n estin, and p-Akt in melanoma versus banal and atypical nevi, and nonmelanocytic lesions. (PubMed id 21915031)1 Shanesmith R.P....Cassarino D.S. (2011)
    450. A new cytosolic pathway from a Parkinson disease-asso ciated kinase, BRPK/PINK1: activation of AKT via mTORC2. (PubMed id 21177249)1 Murata H....Huh N.H. (2011)
    451. ATM-dependent ERK signaling via AKT in response to DN A double-strand breaks. (PubMed id 21263216)1 Khalil A....Valerie K. (2011)
    452. Peripheral expression of key regulatory kinases in Alz heimer's disease and Parkinson's disease. (PubMed id 20106550)1 Armentero M.T....Blandini F. (2011)
    453. PI3K/Akt signaling pathway is involved in the pathoge nesis of ulcerative colitis. (PubMed id 21442372)1 Huang X.L....Gan H.T. (2011)
    454. Campylobacter jejuni induces an anti-inflammatory res ponse in human intestinal epithelial cells through activation of phosphatidylin ositol 3-kinase/Akt pathway. (PubMed id 20863633)1 Li Y.P....Bang D.D. (2011)
    455. Dual function of protein kinase C (PKC) in 12-O-tetra decanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively. (PubMed id 21705328)1 Chung Y.W....Chock P.B. (2011)
    456. The skeleton: a multi-functional complex organ: new i nsights into osteoblasts and their role in bone formation: the central role of PI3Kinase. (PubMed id 21673026)1 Guntur A.R. and Rosen C.J. (2011)
    457. Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis. (PubMed id 21209368)1 Wang S. and Basson M.D. (2011)
    458. Heat shock protein 90 maintains the tumour-like chara cter of rheumatoid synovial cells by stabilizing integrin-linked kinase, extrac ellular signal-regulated kinase and protein kinase B. (PubMed id 21177334)1 Hashiramoto A....Shiozawa S. (2011)
    459. BDNF promotes EGF-induced proliferation and migration of human fetal neural stem/progenitor cells via the PI3K/Akt pathway. (PubMed id 22146375)1 Zhang Q....Jia J. (2011)
    460. Evi1 represses PTEN expression and activates PI3K/AKT /mTOR via interactions with polycomb proteins. (PubMed id 21289308)1 Yoshimi A....Kurokawa M. (2011)
    461. Akt/mTOR counteract the antitumor activities of cixutu mumab, an anti-insulin-like growth factor I receptor monoclonal antibody. (PubMed id 21980128)1 Shin D.H....Lee H.Y. (2011)
    462. Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. (PubMed id 21159778)1 Coloff J.L....Rathmell J.C. (2011)
    463. PI3K/AKT pathway alterations are associated with clin ically aggressive and histologically anaplastic subsets of pilocytic astrocytom a. (PubMed id 21113787)1 Rodriguez E.F....Rodriguez F.J. (2011)
    464. Alternative HER/PTEN/Akt pathway activation in HPV po sitive and negative penile carcinomas. (PubMed id 21407808)1 Stankiewicz E....Berney D.M. (2011)
    465. Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2I+ contributes to human bladder cancer cell survi val. (PubMed id 21592330)1 Shimada K....Konishi N. (2011)
    466. Activation of PI3-kinase stimulates endocytosis of RO MK via Akt1/SGK1-dependent phosphorylation of WNK1. (PubMed id 21355052)1 Cheng C.J. and Huang C.L. (2011)
    467. The serine/threonine kinase ULK1 is a target of multi ple phosphorylation events. (PubMed id 21819378)1 Bach M....Ramm G. (2011)
    468. The relationship among neuregulin 1-stimulated phosph orylation of AKT, psychosis proneness, and habituation of arousal in nonclinica l individuals. (PubMed id 19549627)1 KAcri S....Benedek G. (2011)
    469. Genetic studies of the protein kinase AKT1 in Parkins on's disease. (PubMed id 21741444)1 Ran C....Belin A.C. (2011)
    470. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    471. Arginine methylation of BCL-2 antagonist of cell deat h (BAD) counteracts its phosphorylation and inactivation by Akt. (PubMed id 21444773)1 Sakamaki J....Fukamizu A. (2011)
    472. Fyn is induced by Ras/PI3K/Akt signaling and is requi red for enhanced invasion/migration. (PubMed id 21480388)1 Yadav V. and Denning M.F. (2011)
    473. Dominant inhibition of Akt/protein kinase B signaling by the matrix protein of a negative-strand RNA virus. (PubMed id 20980511)1 Dunn E.F. and Connor J.H. (2011)
    474. AKT1 moderation of cannabis-induced cognitive alterati ons in psychotic disorder. (PubMed id 21775978)1 van Winkel R....Simons C. (2011)
    475. Autophagy and Akt promote survival in glioma. (PubMed id 21266843)1 Fan Q.W. and Weiss W.A. (2011)
    476. A regulatory mechanism involving TBP-1/Tat-Binding Pr otein 1 and Akt/PKB in the control of cell proliferation. (PubMed id 21991300)1 Sepe M....Pollice A. (2011)
    477. Src homology domain 2-containing protein-tyrosine pho sphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-ass ociated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kina se (PI3K)-Akt signaling pathway. (PubMed id 21799016)1 Mittal Y....Ghosh P. (2011)
    478. Targeting AKT protein kinase in gastric cancer. (PubMed id 22199303)1 Almhanna K....Malafa M. (2011)
    479. Akt-dependent glucose metabolism promotes Mcl-1 synth esis to maintain cell survival and resistance to Bcl-2 inhibition. (PubMed id 21670080)1 Coloff J.L....Rathmell J.C. (2011)
    480. Targeting PI3K/Akt/HSP90 signaling sensitizes gastric cancer cells to deoxycholate-induced apoptosis. (PubMed id 20585984)1 Redlak M.J. and Miller T.A. (2011)
    481. Antioxidant c-FLIP inhibits Fas ligand-induced NF-kap paB activation in a phosphatidylinositol 3-kinase/Akt-dependent manner. (PubMed id 21856935)1 Iyer A.K....Rojanasakul Y. (2011)
    482. Cooperative effects of Akt-1 and Raf-1 on the inducti on of cellular senescence in doxorubicin or tamoxifen treated breast cancer cel ls. (PubMed id 21881167)1 Taylor J.R....McCubrey J.A. (2011)
    483. Distinct functional roles of Akt isoforms for prolife ration, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells. (PubMed id 21777670)1 Grabinski N....JA1cker M. (2011)
    484. I+VI^3 integrin regulates macrophage inflammatory respo nses via PI3 kinase/Akt-dependent NF-I_B activation. (PubMed id 20672329)1 Antonov A.S....Verin A.D. (2011)
    485. Constitutively expressed COX-2 in osteoblasts positiv ely regulates Akt signal transduction via suppression of PTEN activity. (PubMed id 20854947)1 Li C.J....Ho M.L. (2011)
    486. PPAR-I^ ligands repress TGFI^-induced myofibroblast dif ferentiation by targeting the PI3K/Akt pathway: implications for therapy of fib rosis. (PubMed id 21253589)1 Kulkarni A.A....Sime P.J. (2011)
    487. Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas. (PubMed id 21945955)1 Yamaguchi H....Furukawa T. (2011)
    488. Involvement of Akt and mTOR in chemotherapeutic- and h ormonal-based drug resistance and response to radiation in breast cancer cells. (PubMed id 21869603)1 Steelman L.S....McCubrey J.A. (2011)
    489. Vimentin is a novel AKT1 target mediating motility an d invasion. (PubMed id 20856200)1 Zhu Q.S....Lev D. (2011)
    490. Critical role of PI3K/Akt/GSK3I^ in motoneuron specifi cation from human neural stem cells in response to FGF2 and EGF. (PubMed id 21887250)1 Ojeda L....Wu P. (2011)
    491. TGF-beta1-induced PI3K/Akt/NF-kappaB/MMP9 signalling pathway is activated in Philadelphia chromosome-positive chronic myeloid leukae mia hemangioblasts. (PubMed id 21288887)1 Zhu X....Zhao R.C. (2011)
    492. Effective targeting of triple-negative breast cancer cells by PF-4942847, a novel oral inhibitor of Hsp 90. (PubMed id 21715568)1 Mehta P.P....Yin M.J. (2011)
    493. Activation of the PI3K/Akt/mTOR pathway correlates wi th tumour progression and reduced survival in patients with urothelial carcinom a of the urinary bladder. (PubMed id 21707707)1 Sun C.H....Pan C.C. (2011)
    494. Akt1 is essential for postnatal mammary gland develop ment, function, and the expression of Btn1a1. (PubMed id 21915327)1 LaRocca J....Hixon M. (2011)
    495. Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cel ls. (PubMed id 21308747)1 Thayyullathil F....Galadari S. (2011)
    496. An Akt-dependent increase in canonical Wnt signaling and a decrease in sclerostin protein levels are involved in strontium ranelate- induced osteogenic effects in human osteoblasts. (PubMed id 21566129)1 Rybchyn M.S....Mason R.S. (2011)
    497. I^-catenin/Tcf-4 complex transcriptionally regulates A KT1 in glioma. (PubMed id 21720709)1 Chen L....Kang C. (2011)
    498. EGFR-AKT-Smad signaling promotes formation of glioma stem-like cells and tumor angiogenesis by ID3-driven cytokine induction. (PubMed id 21975932)1 Jin X....Kim H. (2011)
    499. Different effect of protein kinase B/Akt and extracel lular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines. (PubMed id 21380726)1 Jang E.R....Lee C.S. (2011)
    500. Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, A KT1, and CTNNB1 in medullary thyroid carcinoma. (PubMed id 22199277)1 Schulten H.J....Al-Qahtani M. (2011)
    501. Akt/Nox2/NF-I_B signaling pathway is involved in Tat-i nduced HIV-1 long terminal repeat (LTR) transactivation. (PubMed id 21029719)1 Zhang H.S....Wang Y.O. (2011)
    502. Clk2 and B56-beta mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt. (PubMed id 21329884)2 Rodgers J.T.... Puigserver P. (2011)
    503. Selective activation of Akt1 by mammalian target of r apamycin complex 2 regulates cancer cell migration, invasion, and metastasis. (PubMed id 21339740)1 Kim E.K....Bae S.S. (2011)
    504. IKBKE protein activates Akt independent of phosphatid ylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain m alignant transformation. (PubMed id 21908616)1 Guo J.P....Cheng J.Q. (2011)
    505. Differences in myocardial PTEN expression and Akt sig nalling in type 2 diabetic and nondiabetic patients undergoing coronary bypass surgery. (PubMed id 21521253)1 Wang B....Ansley D.M. (2011)
    506. Icariside II enhances Nrf2 nuclear translocation to up regulate phase II detoxifying enzyme expression coupled with the ERK, Akt and JN K signaling pathways. (PubMed id 22051934)1 Gu J....Chi M. (2011)
    507. Cell-type-specific regulation of raft-associated Akt signaling. (PubMed id 21490677)1 Liu Y....Jia W. (2011)
    508. Nef inhibits glucose uptake in adipocytes and contribu tes to insulin resistance in human immunodeficiency virus type I infection. (PubMed id 21606541)1 Cheney L....Steigbigel R.T. (2011)
    509. Glucose deprivation activates AMPK and induces cell d eath through modulation of Akt in ovarian cancer cells. (PubMed id 21570709)1 Priebe A....Liu J.R. (2011)
    510. The mechanism of insulin-stimulated 4E-BP protein bin ding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling. (PubMed id 21914810)1 Rapley J....Avruch J. (2011)
    511. A cell penetrating peptide derived from azurin inhibi ts angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt. (PubMed id 21667138)1 Mehta R.R....Das Gupta T.K. (2011)
    512. mda-9/Syntenin protein positively regulates the activ ation of Akt protein by facilitating integrin-linked kinase adaptor function du ring adhesion to type I collagen. (PubMed id 21828040)1 Hwangbo C....Lee J.H. (2011)
    513. Low expression of PP2A regulatory subunit B55I+ is ass ociated with T308 phosphorylation of AKT and shorter complete remission duratio n in acute myeloid leukemia patients. (PubMed id 21660042)1 Ruvolo P.P....Kornblau S.M. (2011)
    514. Syk activation of phosphatidylinositol 3-kinase/Akt p revents HtrA2-dependent loss of X-linked inhibitor of apoptosis protein (XIAP) to promote survival of Epstein-Barr virus+ (EBV+) B cell lymphomas. (PubMed id 21908615)1 Hatton O....Martinez O.M. (2011)
    515. MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks. (PubMed id 21623170)1 Fraser M....Bristow R.G. (2011)
    516. Phosphorylation of Akt and ERK1/2 is required for VEGF -A/VEGFR2-induced proliferation and migration of lymphatic endothelium. (PubMed id 22174934)1 Dellinger M.T. and Brekken R.A. (2011)
    517. Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. (PubMed id 21507933)1 Endersby R....Baker S.J. (2011)
    518. Interferon regulatory factor 3 plays an anti-inflammat ory role in microglia by activating the PI3K/Akt pathway. (PubMed id 22208359)1 Tarassishin L....Lee S.C. (2011)
    519. Normal endometrial stromal cells regulate survival an d apoptosis signaling through PI3K/AKt/Survivin pathway in endometrial adenocar cinoma cells in vitro. (PubMed id 21794903)1 Shi M....Zhao X. (2011)
    520. Id1 promotes lung cancer cell proliferation and tumor growth through Akt-related pathway. (PubMed id 21536374)1 Cheng Y.J....Yuan S.S. (2011)
    521. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    522. Genomewide analysis of inherited variation associated with phosphorylation of PI3K/AKT/mTOR signaling proteins. (PubMed id 21949775)1 Hutz J.E....McLeod H.L. (2011)
    523. PM02734 (elisidepsin) induces caspase-independent cel l death associated with features of autophagy, inhibition of the Akt/mTOR signa ling pathway, and activation of death-associated protein kinase. (PubMed id 21690574)1 Ling Y.H....Perez-Soler R. (2011)
    524. RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3-K/Akt pathway. (PubMed id 21212275)1 Wang F.... Shibuya M. (2011)
    525. The prognostic impact of Akt isoforms, PI3K and PTEN r elated to female steroid hormone receptors in soft tissue sarcomas. (PubMed id 22107784)1 Valkov A....Busund L.T. (2011)
    526. Herpes simplex virus requires VP11/12 to activate Src family kinase-phosphoinositide 3-kinase-Akt signaling. (PubMed id 21228233)1 Wagner M.J. and Smiley J.R. (2011)
    527. TLR2 ligand induces protection against cerebral ische mia/reperfusion injury via activation of phosphoinositide 3-kinase/Akt signalin g. (PubMed id 21709150)1 Lu C....Li C. (2011)
    528. E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via I^-catenin-Egr1-mediated PTEN expression. (PubMed id 21297666)1 Lau M.T....Leung P.C. (2011)
    529. Cardiac-specific mindin overexpression attenuates car diac hypertrophy via blocking AKT/GSK3I^ and TGF-I^1-Smad signalling. (PubMed id 21632881)1 Yan L....Li H. (2011)
    530. PML-RARa enhances constitutive autophagic activity thr ough inhibiting the Akt/mTOR pathway. (PubMed id 21673516)1 Huang Y....Chen G.Q. (2011)
    531. Akt fine-tunes NF-I_B-dependent gene expression during T cell activation. (PubMed id 21862580)1 Cheng J....Kane L.P. (2011)
    532. Akt signalling in health and disease. (PubMed id 21620960)2 Hers I.... Tavare J.M. (2011)
    533. Role of peroxisome proliferator-activated receptor ga mma coactivator 1alpha in AKT/PKB-mediated inhibition of hepatitis B virus bios ynthesis. (PubMed id 21880746)1 Ondracek C.R. and McLachlan A. (2011)
    534. Resveratrol enhances the anti-tumor activity of the m TOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppress ing rapamycin-induced AKT signaling. (PubMed id 21168265)1 He X....Eng C. (2011)
    535. Sonic hedgehog pathway promotes metastasis and lympha ngiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer. (PubMed id 21975935)1 Yoo Y.A....Oh S.C. (2011)
    536. Age-dependent accumulation of soluble amyloid beta (A beta) oligomers reverses the neuroprotective effect of soluble amyloid precurso r protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K )/Akt-GSK-3beta pathway in Alzheimer mouse model. (PubMed id 21460223)1 Jimenez S....Vitorica J. (2011)
    537. Serotonin activates MAP kinase and PI3K/Akt signaling pathways in prostate cancer cell lines. (PubMed id 19926313)1 Dizeyi N....Abrahamsson P.A. (2011)
    538. Phospho-ERK and AKT status, but not KRAS mutation stat us, are associated with outcomes in rectal cancer treated with chemoradiotherapy . (PubMed id 21910869)1 Davies J.M....O'Neil B.H. (2011)
    539. Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer. (PubMed id 21406404)1 Gonzalez M.E....Kleer C.G. (2011)
    540. Insulin-dependent phosphatidylinositol 3-kinase/Akt a nd ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis. (PubMed id 21646299)1 Numata T....Kuwano K. (2011)
    541. Recent development of anticancer therapeutics targeti ng Akt. (PubMed id 21110830)1 Morrow J.K....Zhang S. (2011)
    542. Deactivation of Akt by a small molecule inhibitor tar geting pleckstrin homology domain and facilitating Akt ubiquitination. (PubMed id 21464312)1 Jo H....Luo H.R. (2011)
    543. PPARI+ and PPARI^ protect against HIV-1-induced MMP-9 o verexpression via caveolae-associated ERK and Akt signaling. (PubMed id 21840940)1 Huang W....Toborek M. (2011)
    544. Inhibition of HIV-1 Tat-mediated transcription by a co umarin derivative, BPRHIV001, through the Akt pathway. (PubMed id 21697490)1 Lin P.H....Chang S.Y. (2011)
    545. AKT/FOXO signaling enforces reversible differentiatio n blockade in myeloid leukemias. (PubMed id 21884932)1 Sykes S.M....Scadden D.T. (2011)
    546. Curcumin modulates nuclear factor kappaB (NF-kappaB)-m ediated inflammation in human tenocytes in vitro: role of the phosphatidylinosit ol 3-kinase/Akt pathway. (PubMed id 21669872)1 Buhrmann C....Shakibaei M. (2011)
    547. Norovirus RNA-dependent RNA polymerase is phosphoryla ted by an important survival kinase, Akt. (PubMed id 21849454)1 Eden J.S....Brown A.J. (2011)
    548. Mutational analysis of PTEN/PIK3CA/AKT pathway in ora l squamous cell carcinoma. (PubMed id 21824802)1 Cohen Y....Hirshberg A. (2011)
    549. Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase. (PubMed id 21767636)1 Su C.H....Lee W.P. (2011)
    550. von Hippel-Lindau protein promotes Skp2 destabilizati on on DNA damage. (PubMed id 21358672)1 Roe J.S....Youn H.D. (2011)
    551. Roles of AKT1 and AKT2 in non-small cell lung cancer cell survival, growth, and migration. (PubMed id 21722267)1 Lee M.W....Koo H.H. (2011)
    552. Effect of eccentric exercise velocity on akt/mtor/p70 (s6k) signaling in human skeletal muscle. (PubMed id 21609291)1 Roschel H....Tricoli V. (2011)
    553. Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma. (PubMed id 21859846)1 Schatz J.H....Wendel H.G. (2011)
    554. PTEN, pAKT, and pmTOR expression and subcellular dist ribution in primary renal cell carcinomas and their metastases. (PubMed id 21696297)1 Hager M....Kolbitsch C. (2011)
    555. IKKb and NF-kB transcription govern lymphoma cell surv ival through AKT-induced plasma membrane trafficking of GLUT1. (PubMed id 21987722)1 Sommermann T.G....Cahir-McFarland E. (2011)
    556. Akt/PKB isoforms expression in the human lumbar hernia ted disc: correlation with clinical and MRI findings. (PubMed id 21590431)1 Pasku D....Spandidos D.A. (2011)
    557. Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating the Src/PI3K/Akt pathway. (PubMed id 21994334)1 Liu H....Gu J. (2011)
    558. Cigarette smoke induces Akt protein degradation by th e ubiquitin-proteasome system. (PubMed id 21778238)1 Kim S.Y....Lee Y.S. (2011)
    559. PrLZ protects prostate cancer cells from apoptosis in duced by androgen deprivation via the activation of Stat3/Bcl-2 pathway. (PubMed id 21385902)1 Zhang D....Li L. (2011)
    560. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    561. LRRK2 directly phosphorylates Akt1 as a possible phys iological substrate: impairment of the kinase activity by Parkinson's disease-a ssociated mutations. (PubMed id 21658387)1 Ohta E....Obata F. (2011)
    562. Opposite effects of HIV-1 p17 variants on PTEN activa tion and cell growth in B cells. (PubMed id 21423810)1 Giagulli C....Caruso A. (2011)
    563. Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipo dia and downregulates MMPs expression. (PubMed id 21276823)1 Kwiatkowska A....Kaminska B. (2011)
    564. Insulin-activated Akt rescues AI^ oxidative stress-ind uced cell death by orchestrating molecular trafficking. (PubMed id 21624038)1 Picone P....Di Carlo M. (2011)
    565. Regulation of AKT phosphorylation at Ser473 and Thr30 8 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner. (PubMed id 21445305)1 Yung H.W....Burton G.J. (2011)
    566. Chelation of lysosomal iron protects dopaminergic SH- SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophag y and Akt dephosphorylation. (PubMed id 21742779)1 Castino R....Isidoro C. (2011)
    567. Interleukin-10-induced gene expression and suppressiv e function are selectively modulated by the PI3K-Akt-GSK3 pathway. (PubMed id 21255011)1 Antoniv T.T. and Ivashkiv L.B. (2011)
    568. Endometrial cancer and genetic variation in PTEN, PIK 3CA, AKT1, MLH1, and MSH2 within a population-based case-control study. (PubMed id 21093899)1 Lacey J.V....Garcia-Closas M. (2011)
    569. Growth factor receptors gene expression and Akt phosp horylation in benign human thyroid nodules are unaffected by chronic thyrotropi n suppression. (PubMed id 20886414)1 Sponziello M.L....Russo D. (2011)
    570. A methylation and phosphorylation switch between an a djacent lysine and serine determines human DNMT1 stability. (PubMed id 21151116)1 EstA"ve P.O....Pradhan S. (2011)
    571. Bimodal regulation of FoxO3 by AKT and 14-3-3. (PubMed id 21621563)1 Dobson M....Tzivion G. (2011)
    572. Modulation of PGE2-induced EP4 expression on snail sig naling and the impact on epithelial-mesenchymal transition: significance of EP4 antagonism. (PubMed id 22199300)1 Kim H.N....Narayanan B. (2011)
    573. Discovery and SAR of spirochromane Akt inhibitors. (PubMed id 21392984)2 Kallan N.C.... Skelton N.J. (2011)
    574. ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells. (PubMed id 22169232)1 Shen Z....Wang X. (2011)
    575. Lack of compensatory pAKT activation and eIF4E phosph orylation of lymphoma cells towards mTOR inhibitor, RAD001. (PubMed id 21334199)1 Kuo S.H....Cheng A.L. (2011)
    576. Interplay between FOXO, TOR, and Akt. (PubMed id 21440577)1 Hay N. (2011)
    577. TGF-I^ stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smoo th muscle. (PubMed id 21913799)1 Osman N....Little P.J. (2011)
    578. Cellular repressor of E1A-stimulated genes regulates v ascular endothelial cell migration by the ILK/AKT/mTOR/VEGF(165) signaling pathw ay. (PubMed id 21939655)1 Zhang H....Li S. (2011)
    579. Detachment-mediated resistance to TRAIL-induced apopt osis is associated with stimulation of the PI3K/Akt pathway in fetal and adenoc arcinoma epithelial colon cells. (PubMed id 21482133)1 KoA8A- L....KozubA-k A. (2011)
    580. Direct interaction of a-synuclein and AKT regulates IG F-1 signaling: implication of Parkinson disease. (PubMed id 21474915)1 Chung J.Y....Park B.J. (2011)
    581. GLI2 transcription factor mediates cytokine cross-tal k in the tumor microenvironment. (PubMed id 21454528)1 Elsawa S.F....Fernandez-Zapico M.E. (2011)
    582. IL-17 induces AKT-dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma. (PubMed id 22171994)1 Gu F.M....Zhou J. (2011)
    583. Matrix-dependent regulation of AKT in Hepsin-overexpressing PC3 prostate cancer cells. (PubMed id 21750652)1 Wittig-Blaich S.M....Wittig R. (2011)
    584. SPARC functions as an anti-stress factor by inactivat ing p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell surv ival. (PubMed id 21685937)1 Fenouille N....Tartare-Deckert S. (2011)
    585. Functional human regulatory T cells fail to control a utoimmune inflammation due to PKB/c-akt hyperactivation in effector cells. (PubMed id 21828127)1 Wehrens E.J....van Wijk F. (2011)
    586. Regulation of FOXO protein stability via ubiquitinati on and proteasome degradation. (PubMed id 21238503)1 Huang H. and Tindall D.J. (2011)
    587. Critical role for programmed death 1 signaling and pr otein kinase B in augmented regulatory T-cell induction in cord blood. (PubMed id 21868077)1 de Roock S....de Kleer I.M. (2011)
    588. Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/I^-catenin signaling. (PubMed id 21325624)1 Kolegraff K....Nusrat A. (2011)
    589. Wnt/I^-catenin signaling regulates MAPK and Akt1 expre ssion and growth of hepatocellular carcinoma cells. (PubMed id 21391741)1 Wang X.H....Xu W. (2011)
    590. Akt associates with nuclear factor kappaB and plays a n important role in chemoresistance of gastric cancer cells. (PubMed id 20514451)1 Yu L.L....Si J.M. (2010)
    591. The PI3K-Akt-mTOR pathway in initiation and progressi on of thyroid tumors. (PubMed id 19897009)1 Saji M. and Ringel M.D. (2010)
    592. In vitro evaluation of pan-PI3-kinase inhibitor SF112 6 in trastuzumab-sensitive and trastuzumab-resistant HER2-over-expressing breas t cancer cells. (PubMed id 19636556)1 Ozbay T....Nahta R. (2010)
    593. Endocrine resistance associated with activated ErbB s ystem in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signali ng pathways. (PubMed id 19609946)1 Ghayad S.E....Cohen P.A. (2010)
    594. Mutational and immunohistochemical study of the PI3K/ Akt pathway in papillary thyroid carcinoma in Greece. (PubMed id 20186503)1 Sozopoulos E....Tseleni-Balafouta S. (2010)
    595. Reciprocal regulation of AKT and MAP kinase dictates virus-host cell fusion. (PubMed id 20164223)1 Sharma N.R....Sarkar D.P. (2010)
    596. Molecular genotyping of papillary thyroid carcinoma f ollicular variant according to its histological subtypes (encapsulated vs infil trative) reveals distinct BRAF and RAS mutation patterns. (PubMed id 20526288)1 Rivera M....Ghossein R.A. (2010)
    597. miR-22 forms a regulatory loop in PTEN/AKT pathway an d modulates signaling kinetics. (PubMed id 20523723)1 Bar N. and Dikstein R. (2010)
    598. Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage. (PubMed id 20187936)1 GarcA-a S....Conde C. (2010)
    599. The insulin-like growth factor receptor I promotes mo tility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin. (PubMed id 20395438)1 Metalli D....Morrione A. (2010)
    600. Stathmin is involved in arsenic trioxide-induced apop tosis in human cervical cancer cell lines via PI3K linked signal pathway. (PubMed id 20657188)1 Wang X....Zhang H.Z. (2010)
    601. Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian targe t of rapamycin signaling. (PubMed id 20488790)1 van de Laar L....Woltman A.M. (2010)
    602. Upregulation of DLX5 promotes ovarian cancer cell pro liferation by enhancing IRS-2-AKT signaling. (PubMed id 21045156)1 Tan Y....Testa J.R. (2010)
    603. Beta-arrestin-1 mediates the endothelin-1-induced act ivation of Akt and integrin-linked kinase. (PubMed id 20725137)1 Cianfrocca R....Bagnato A. (2010)
    604. Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2. (PubMed id 20534535)1 Mund T. and Pelham H.R. (2010)
    605. Immunosuppressive cyclosporin A activates AKT in kera tinocytes through PTEN suppression: implications in skin carcinogenesis. (PubMed id 20154081)1 Han W....He Y.Y. (2010)
    606. Wingless (Wnt)-3A induces trophoblast migration and m atrix metalloproteinase-2 secretion through canonical Wnt signaling and protein kinase B/AKT activation. (PubMed id 19887570)1 Sonderegger S....KnAPfler M. (2010)
    607. Ovarian cancer ascites protects from TRAIL-induced ce ll death through alphavbeta5 integrin-mediated focal adhesion kinase and Akt ac tivation. (PubMed id 20400979)1 Lane D....PichAc A. (2010)
    608. DOCK180 is a Rac activator that regulates cardiovascu lar development by acting downstream of CXCR4. (PubMed id 20829512)1 Sanematsu F....Fukui Y. (2010)
    609. Inhibitory effect of baicalein on IL-6-mediated signa ling cascades in human myeloma cells. (PubMed id 19878271)1 Liu S....Kawano M. (2010)
    610. miR-149* induces apoptosis by inhibiting Akt1 and E2F 1 in human cancer cells. (PubMed id 20623644)1 Lin R.J....Yu A.L. (2010)
    611. Rituximab inhibits B-cell receptor signaling. (PubMed id 19965664)1 Kheirallah S....Bezombes C. (2010)
    612. The rapamycin-derivative RAD001 (everolimus) inhibits cell viability and interacts with the Akt-mTOR-p70S6K pathway in human medulla ry thyroid carcinoma cells. (PubMed id 19815051)1 Grozinsky-Glasberg S....Shimon I. (2010)
    613. Histone deacetylase 3 is critical in endothelial surv ival and atherosclerosis development in response to disturbed flow. (PubMed id 20026773)1 Zampetaki A....Xu Q. (2010)
    614. Functional characterization of a haplotype in the AKT 1 gene associated with glucose homeostasis and metabolic syndrome. (PubMed id 20872231)1 Harmon B.T....Hoffman E.P. (2010)
    615. Genetic association of the interaction between the BD NF and GSK3B genes and major depressive disorder in a Chinese population. (PubMed id 20033742)1 Zhang K....Shen Y. (2010)
    616. Interplay between Akt and p38 MAPK pathways in the re gulation of renal tubular cell apoptosis associated with diabetic nephropathy. (PubMed id 19726550)1 Rane M.J....Cai L. (2010)
    617. PI3K/Akt promotes GRP78 accumulation and inhibits end oplasmic reticulum stress-induced apoptosis in HEK293 cells. (PubMed id 20492754)1 Dai R.Y....Li H. (2010)
    618. Nifedipine inhibits vascular smooth muscle cell dedif ferentiation via downregulation of Akt signaling. (PubMed id 20530298)1 Kaimoto T....Rakugi H. (2010)
    619. Clinical significance of genetic variations in the PI 3K/PTEN/AKT/mTOR pathway in Korean patients with colorectal cancer. (PubMed id 21412012)1 Kim J.G....Choi G.S. (2010)
    620. Maggot excretions/secretions induces human microvascu lar endothelial cell migration through AKT1. (PubMed id 19757167)1 Wang S.Y....Lv D.C. (2010)
    621. High level of apoptosis and low AKT activation in mas s screening as opposed to standard neuroblastoma. (PubMed id 20459571)1 Sartelet H....Vassal G. (2010)
    622. Alkylation of the tumor suppressor PTEN activates Akt and I^-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer. (PubMed id 20975834)1 Covey T.M....Fitzpatrick F.A. (2010)
    623. A G(i) -independent mechanism mediating Akt phosphory lation in platelets. (PubMed id 20586915)1 Xiang B....Li Z. (2010)
    624. [Celastrol down-regulates expression of P-Akt and cyc lin D1 in HL-60 cells and induces apoptosis]. (PubMed id 20723296)1 Ma Y.L....Wang Y. (2010)
    625. Plexin-B1 silencing inhibits ovarian cancer cell migr ation and invasion. (PubMed id 21059203)1 Ye S....Wang S. (2010)
    626. Transcriptional regulation of the endogenous danger s ignal tenascin-C: a novel autocrine loop in inflammation. (PubMed id 20107185)1 Goh F.G....Midwood K.S. (2010)
    627. Activation of Akt and MAPK pathways enhances the tumo rigenicity of CD133+ primary colon cancer cells. (PubMed id 20530554)1 Wang Y.K....Huang J. (2010)
    628. Dopamine, by acting through its D2 receptor, inhibits insulin-like growth factor-I (IGF-I)-induced gastric cancer cell proliferation via up-regulation of KrA1ppel-like factor 4 through down-regulation of IGF-IR a nd AKT phosphorylation. (PubMed id 21075859)1 Ganguly S....Basu S. (2010)
    629. PI(3)king apart PTEN's role in cancer. (PubMed id 20622047)1 Zhang S. and Yu D. (2010)
    630. Vascular endothelial growth factor receptor 1 contrib utes to Escherichia coli K1 invasion of human brain microvascular endothelial c ells through the phosphatidylinositol 3-kinase/Akt signaling pathway. (PubMed id 20805333)1 Zhao W.D....Chen Y.H. (2010)
    631. Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis. (PubMed id 19933775)1 Chen W....Lin Y. (2010)
    632. Design of selective, ATP-competitive inhibitors of Akt. (PubMed id 20481595)2 Freeman-Cook K.D.... Morris J. (2010)
    633. Suppression of ADAM17-mediated Lyn/Akt pathways induc es apoptosis of human leukemia U937 cells: Bungarus multicinctus protease inhib itor-like protein-1 uncovers the cytotoxic mechanism. (PubMed id 20679348)1 Liu W.H. and Chang L.S. (2010)
    634. Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/ AKT/glycogen synthase kinase 3beta signaling. (PubMed id 20308328)1 Edouard T....Raynal P. (2010)
    635. p-AKT overexpression in primary renal cell carcinomas and their metastases. (PubMed id 20844931)1 Hager M....Kolbitsch C. (2010)
    636. Inhibition of NF-kappaB and Akt pathways by an antibo dy-avidin fusion protein sensitizes malignant B-cells to cisplatin-induced apop tosis. (PubMed id 20372806)1 Suzuki E....Bonavida B. (2010)
    637. Glutamate promotes cell growth by EGFR signaling on U -87MG human glioblastoma cell line. (PubMed id 19997873)1 Schunemann D.P....da Rocha A.B. (2010)
    638. Clinical significance of pAKT and CD44v6 overexpressi on with breast cancer. (PubMed id 20157733)1 Yu P....Li K. (2010)
    639. PTEN differentially regulates expressions of ICAM-1 a nd VCAM-1 through PI3K/Akt/GSK-3I^/GATA-6 signaling pathways in TNF-I+-activated human endothelial cells. (PubMed id 20864106)1 Tsoyi K....Chang K.C. (2010)
    640. Inactivation of PI3k/Akt signaling pathway and activa tion of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leu kemia cells in vitro. (PubMed id 20512574)1 Liu J.J....Huang R.W. (2010)
    641. HIV-1 inhibits autophagy in bystander macrophage/monoc ytic cells through Src-Akt and STAT3. (PubMed id 20661303)1 Van Grol J....Subauste C.S. (2010)
    642. AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers. (PubMed id 21321378)1 Guirouilh-Barbat J.K....Lopez B.S. (2010)
    643. Growth factors protect intestinal stem cells from rad iation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis. (PubMed id 19966853)1 Qiu W....Yu J. (2010)
    644. Correlation between Mcl-1 and pAKT protein expression in colorectal cancer. (PubMed id 21151390)1 Henderson-Jackson E.B....Coppola D. (2010)
    645. An orally available small-molecule inhibitor of c-Met , PF-2341066, reduces tumor burden and metastasis in a preclinical model of ova rian cancer metastasis. (PubMed id 20072648)1 Zillhardt M....Lengyel E. (2010)
    646. [Correlation of expression of PTEN with AKT phosphory lation level in leukemia cells]. (PubMed id 21129241)1 Zhang Y.Y....Meng W.T. (2010)
    647. Rarity of AKT1 and AKT3 E17K mutations in squamous ce ll carcinoma of lung. (PubMed id 20980808)1 Do H....Dobrovic A. (2010)
    648. Akt activation is a common event in pediatric maligna nt gliomas and a potential adverse prognostic marker: a report from the Childre n's Oncology Group. (PubMed id 20607350)1 Pollack I.F....Jakacki R.I. (2010)
    649. Liver X Receptor activation downregulates AKT surviva l signaling in lipid rafts and induces apoptosis of prostate cancer cells. (PubMed id 20190811)1 Pommier A.J....Lobaccaro J.M. (2010)
    650. Antiproliferative effect of growth hormone-releasing hormone (GHRH) antagonist on ovarian cancer cells through the EGFR-Akt pathway. (PubMed id 20509930)1 Guo J....Leung P.C. (2010)
    651. HER-2/AKT expression in upper urinary tract urothelia l carcinoma: prognostic implications. (PubMed id 20651405)1 Izquierdo L....Alcaraz A. (2010)
    652. Amino acids stimulate Akt phosphorylation, and reduce IL-8 production and NF-I_B activity in HepG2 liver cells. (PubMed id 20512787)1 van Meijl L.E....Mensink R.P. (2010)
    653. Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6K B2, and PDK1 and risk of colon or rectal cancer. (PubMed id 21035469)1 Slattery M.L....Wolff R.K. (2010)
    654. CNK1 is a novel Akt interaction partner that promotes cell proliferation through the Akt-FoxO signalling axis. (PubMed id 20383191)1 Fritz R.D....Radziwill G. (2010)
    655. Overexpression of fucosyltransferase IV promotes A431 cell proliferation through activating MAPK and PI3K/Akt signaling pathways. (PubMed id 20506505)1 Yang X.S....Yan Q. (2010)
    656. Regulation of mutual inhibitory activities between AM PK and Akt with quercetin in MCF-7 breast cancer cells. (PubMed id 21042744)1 Lee Y.K. and Park O.J. (2010)
    657. Genetic association of the AKT1 gene with schizophren ia in a British population. (PubMed id 20421846)1 Mathur A....Wei J. (2010)
    658. Involvement of Akt in synergistic effects of thermo-c hemotherapy on human small cell lung cancer H446 cell apoptosis. (PubMed id 20346214)1 Wang L....Shi X.Q. (2010)
    659. Preliminary evidence of ethnic divergence in associat ions of putative genetic variants for methamphetamine dependence. (PubMed id 20478633)1 Bousman C.A....Everall I.P. (2010)
    660. Analysis of PI3K/AKT/mTOR signalling pathway in high risk neuroblastic tumours. (PubMed id 21290341)1 IA1ycka-A9wieszewska E....Balcerska A. (2010)
    661. FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. (PubMed id 20412774)1 Chen C.C....Hay N. (2010)
    662. mTORC2 can associate with ribosomes to promote cotran slational phosphorylation and stability of nascent Akt polypeptide. (PubMed id 21045808)1 Oh W.J....Jacinto E. (2010)
    663. Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a. (PubMed id 21045158)1 Shultz J.C....Chalfant C.E. (2010)
    664. Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clini cal implications. (PubMed id 20228224)1 Badve S....Nakshatri H. (2010)
    665. Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (2010)
    666. Phosph-Akt1 expression is associated with a favourabl e prognosis in pancreatic cancer. (PubMed id 20697673)1 Liu J....Qiu Z.J. (2010)
    667. Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer. (PubMed id 19621391)1 Uddin S....Munkarah A. (2010)
    668. TNF-alpha induces matrix metalloproteinase-9 expressi on in A549 cells: role of TNFR1/TRAF2/PKCalpha-dependent signaling pathways. (PubMed id 20333651)1 Lee I.T....Yang C.M. (2010)
    669. Beta-arrestin 2 modulates resveratrol-induced apoptos is and regulation of Akt/GSK3A9 pathways. (PubMed id 20457218)1 Sun X....Yin D. (2010)
    670. Arsenite causes down-regulation of Akt and c-Fos, cel l cycle dysfunction and apoptosis in glutathione-deficient cells. (PubMed id 20336670)1 Habib G.M. (2010)
    671. II_B kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia. (PubMed id 20671123)1 Chapuis N....Bouscary D. (2010)
    672. PH domain leucine-rich repeat protein phosphatase 1 c ontributes to maintain the activation of the PI3K/Akt pro-survival pathway in H untington's disease striatum. (PubMed id 19745829)1 Saavedra A....PAcrez-Navarro E. (2010)
    673. Erythropoietin plus insulin-like growth factor-I prote cts against neuronal damage in a murine model of human immunodeficiency virus-as sociated neurocognitive disorders. (PubMed id 20818790)1 Kang Y.J....Lipton S.A. (2010)
    674. Rapamycin sensitizes Akt inhibition in malignant huma n breast epithelial cells. (PubMed id 20417028)1 Zheng J....Novak R.F. (2010)
    675. Curcumin inhibits hepatitis C virus replication via s uppressing the Akt-SREBP-1 pathway. (PubMed id 20026048)1 Kim K....Cheong J. (2010)
    676. Upregulation of PTEN in glioma cells by cord blood me senchymal stem cells inhibits migration via downregulation of the PI3K/Akt path way. (PubMed id 20436671)1 Dasari V.R....Rao J.S. (2010)
    677. The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling. (PubMed id 20574456)1 Hussain S....Galardy P.J. (2010)
    678. Phosphatidylinositol-3-kinase/akt regulates bleomycin -induced fibroblast proliferation and collagen production. (PubMed id 19520917)1 Lu Y....Rojanasakul Y. (2010)
    679. BMP2 accelerates the motility and invasiveness of gas tric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Ak t pathway. (PubMed id 19835871)1 Kang M.H....Yoo Y.A. (2010)
    680. Hypoxia induces BMP-2 expression via ILK, Akt, mTOR, and HIF-1 pathways in osteoblasts. (PubMed id 20232298)1 Tseng W.P....Tang C.H. (2010)
    681. Association between AKT1 but not AKTIP genetic varian ts and increased risk for suicidal behavior in bipolar patients. (PubMed id 20132317)1 Magno L.A....Romano-Silva M.A. (2010)
    682. Soluble glypican 3 inhibits the growth of hepatocellu lar carcinoma in vitro and in vivo. (PubMed id 19816934)1 Zittermann S.I....Filmus J. (2010)
    683. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (2010)
    684. Association of AKT1 gene variants and protein express ion in both schizophrenia and bipolar disorder. (PubMed id 20214684)1 Karege F....Malafosse A. (2010)
    685. Entamoeba histolytica cysteine proteinase 5 binds int egrin on colonic cells and stimulates NFkappaB-mediated pro-inflammatory respon ses. (PubMed id 20837477)1 Hou Y....Chadee K. (2010)
    686. Annexin 2 regulates endothelial morphogenesis by cont rolling AKT activation and junctional integrity. (PubMed id 20947498)1 Su S.C....Bayless K.J. (2010)
    687. Replication study of association between ADCYAP1 gene polymorphisms and schizophrenia. (PubMed id 20414143)1 Koga M....Arinami T. (2010)
    688. Purinergic receptor-mediated rapid depletion of nucle ar phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases. (PubMed id 20605778)1 Mistafa O....Stenius U. (2010)
    689. Absence of activating somatic mutations of PI3KCA and AKT1 genes in South Indian women with endometriosis. (PubMed id 20493625)1 Rai P....Shivaji S. (2010)
    690. Shear-induced interleukin-6 synthesis in chondrocytes : roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A- and PI3-K/Akt- dependent NF-kappaB activation. (PubMed id 20516073)1 Wang P....Konstantopoulos K. (2010)
    691. Phosphatome profiling reveals PTPN2, PTPRJ and PTEN a s potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells. (PubMed id 19922411)1 Omerovic J....Prior I.A. (2010)
    692. cIAP2 upregulated by E6 oncoprotein via epidermal gro wth factor receptor/phosphatidylinositol 3-kinase/AKT pathway confers resistanc e to cisplatin in human papillomavirus 16/18-infected lung cancer. (PubMed id 20959404)1 Wu H.H....Lee H. (2010)
    693. P21-activated kinase 1 stimulates colon cancer cell g rowth and migration/invasion via ERK- and AKT-dependent pathways. (PubMed id 20595063)1 Huynh N....He H. (2010)
    694. No association between AKT1 polymorphism and schizoph renia: a case-control study in a Korean population and a meta-analysis. (PubMed id 19931325)1 Lee K.Y....Kim Y.S. (2010)
    695. Ligation of beta4 integrins activates PKB/Akt and ERK 1/2 by distinct pathways-relevance of the keratin filament. (PubMed id 20307589)1 Kippenberger S....Bernd A. (2010)
    696. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1 Liu C.Y....Christiani D.C. (2010)
    697. The Skp2 promoter integrates signaling through the NF -kappaB, p53, and Akt/GSK3beta pathways to regulate autophagy and apoptosis. (PubMed id 20513428)1 BarrAc B. and Perkins N.D. (2010)
    698. Akt-phosphorylated mitogen-activated kinase-activatin g death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas- associated death domain (FADD) association with death receptor 4. (PubMed id 20484047)1 Li P....Prabhakar B.S. (2010)
    699. COMMD1 downregulates the epithelial sodium channel th rough Nedd4-2. (PubMed id 20237237)1 Ke Y....McDonald F.J. (2010)
    700. Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activatio n and downregulation of Bcl-2 and survivin expression and Akt signaling. (PubMed id 19676105)1 Watson J.L....Hoskin D.W. (2010)
    701. Hepatocyte growth factor protects hepatoblastoma cell s from chemotherapy-induced apoptosis by AKT activation. (PubMed id 20372801)1 Grotegut S....Von Schweinitz D. (2010)
    702. IGF-I activation of the AKT pathway is impaired in vi sceral but not subcutaneous preadipocytes from obese subjects. (PubMed id 20555032)1 Cleveland-Donovan K....Boney C.M. (2010)
    703. Induction of cellular apoptosis in human breast cance r by DLBS1425, a Phaleria macrocarpa compound extract, via down-regulation of P I3-kinase/AKT pathway. (PubMed id 20703095)1 Tandrasasmita O.M....Tjandrawinata R.R. (2010)
    704. Akt inhibition up-regulates MMP1 through a CCN2-depen dent pathway in human dermal fibroblasts. (PubMed id 20201953)1 Bujor A.M....Trojanowska M. (2010)
    705. Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling. (PubMed id 19855431)1 Yalcin A....Chesney J. (2010)
    706. Role of AKT-glycogen synthase kinase axis in monocyte activation in human beings with and without type 2 diabetes. (PubMed id 19754670)1 Nandy D....Basu A. (2010)
    707. Programmed cell death 4 (PDCD4) enhances the sensitiv ity of gastric cancer cells to TRAIL-induced apoptosis by inhibiting the PI3K/A kt signaling pathway. (PubMed id 20560677)1 Wang W.Q....Fang D.C. (2010)
    708. Protein phosphatase 2A reactivates FOXO3a through a d ynamic interplay with 14-3-3 and AKT. (PubMed id 20110348)1 Singh A....Khosravi-Far R. (2010)
    709. Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells. (PubMed id 20419107)1 Xu J....Wu G.S. (2010)
    710. ICAM-3 enhances the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt a nd CREB. (PubMed id 19956847)1 Park J.K....Um H.D. (2010)
    711. Role of Abl kinase and the Wave2 signaling complex in HIV-1 entry at a post-hemifusion step. (PubMed id 20585556)1 Harmon B....Ratner L. (2010)
    712. PTH inactivates the AKT survival pathway in the colon ic cell line Caco-2. (PubMed id 20005908)1 Calvo N....Gentili C. (2010)
    713. p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment. (PubMed id 20182617)1 Feng Z. (2010)
    714. Genetic variations of the PI3K-AKT-mTOR pathway and c linical outcome in muscle invasive and metastatic bladder cancer patients. (PubMed id 20530239)1 Chen M....Wu X. (2010)
    715. High expression of ErbB2 contributes to cholangiocarc inoma cell invasion and proliferation through AKT/p70S6K. (PubMed id 20731018)1 Treekitkarnmongkol W. and Suthiphongchai T. (2010)
    716. Biological effects induced by insulin-like growth fac tor binding protein 3 (IGFBP-3) in malignant melanoma. (PubMed id 19588500)1 Oy G.F....renes V.A. (2010)
    717. Oscillatory flow-induced proliferation of osteoblast- like cells is mediated by alphavbeta3 and beta1 integrins through synergistic i nteractions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway. (PubMed id 19889638)1 Lee D.Y....Chien S. (2010)
    718. [Effects of PTEN over-expression on phosphatidyl inos itol 3-kinase/protein kinase B signal pathway in ovarian epithelial cancer cell s]. (PubMed id 21092549)1 Zhai Y.N....Shen Y.F. (2010)
    719. Facilitating Akt clearance via manipulation of Hsp70 activity and levels. (PubMed id 19889640)1 Koren J....Dickey C.A. (2010)
    720. Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells: roles for AMP-activated protein kinase, Akt, and FOXO1. (PubMed id 19887561)1 Reiter C.E....Quon M.J. (2010)
    721. Inhibition of aldose reductase prevents growth factor -induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells. (PubMed id 20354121)1 Ramana K.V....Srivastava S.K. (2010)
    722. Adhesion of ST6Gal I-mediated human colon cancer cell s to fibronectin contributes to cell survival by integrin beta1-mediated paxill in and AKT activation. (PubMed id 20127017)1 Lee M....Lee Y.S. (2010)
    723. Regulation of the Ca(2+) channel TRPV6 by the kinases SGK1, PKB/Akt, and PIKfyve. (PubMed id 20041238)1 Sopjani M....Lang F. (2010)
    724. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1 Segat L....Crovella S. (2010)
    725. Neuregulin 1-induced AKT phosphorylation in monozygot ic twins discordant for schizophrenia. (PubMed id 20371257)1 Seres I....KAcri S. (2010)
    726. AKT controls human first trimester trophoblast cell s ensitivity to FAS-mediated apoptosis by regulating XIAP expression. (PubMed id 19726736)1 Straszewski-Chavez S.L....Mor G. (2010)
    727. The Akt isoforms are present at distinct subcellular locations. (PubMed id 20018949)1 Santi S.A. and Lee H. (2010)
    728. Cutting edge: Vascular endothelial growth factor-medi ated signaling in human CD45RO+ CD4+ T cells promotes Akt and ERK activation an d costimulates IFN-gamma production. (PubMed id 20008289)1 Basu A....Briscoe D.M. (2010)
    729. Inhibition of CtBP1 activity by Akt-mediated phosphor ylation. (PubMed id 20361981)1 Merrill J.C....Wotton D. (2010)
    730. Insulin regulates alveolar epithelial function by ind ucing Na+/K+-ATPase translocation to the plasma membrane in a process mediated by the action of Akt. (PubMed id 20332111)1 Comellas A.P....Dada L.A. (2010)
    731. Suppression of DNA-PKcs enhances FGF-2 dependent huma n endothelial cell proliferation via negative regulation of Akt. (PubMed id 19781633)1 Mannell H....KrAPtz F. (2010)
    732. Immunohistochemical detection of phospho-Akt, phospho -BAD, HER2 and oestrogen receptors alpha and beta in Malaysian breast cancer pa tients. (PubMed id 19882362)1 Seow H.F....Rohaizak M. (2010)
    733. Purification and characterization of recombinant CH3 domain fragment of the CREB-binding protein. (PubMed id 19995607)1 Drendall C.I....Dietze E.C. (2010)
    734. Akt and autophagy cooperate to promote survival of dr ug-resistant glioma. (PubMed id 21062993)1 Fan Q.W....Weiss W.A. (2010)
    735. From man to mouse and back again: advances in definin g tumor AKTivities in vivo. (PubMed id 20940316)1 Restuccia D.F. and Hemmings B.A. (2010)
    736. Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induce d protein kinase 3). (PubMed id 20687898)1 Mouton V....Rider M.H. (2010)
    737. Sorafenib downregulates ERK/Akt and STAT3 survival pa thways and induces apoptosis in a human neuroblastoma cell line. (PubMed id 20490331)1 Chai H....Brown R.E. (2010)
    738. Angiotensin II/angiotensin II type I receptor (AT1R) signaling promotes MCF-7 breast cancer cells survival via PI3-kinase/Akt pathwa y. (PubMed id 20458733)1 Zhao Y....Fu S. (2010)
    739. Sunitinib induces apoptosis and growth arrest of medu lloblastoma tumor cells by inhibiting STAT3 and AKT signaling pathways. (PubMed id 20053726)1 Yang F....Yu H. (2010)
    740. E17K substitution in AKT1 in prostate cancer. (PubMed id 20407443)1 Boormans J.L....Trapman J. (2010)
    741. Casein kinase 2 dependent phosphorylation of neprilys in regulates receptor tyrosine kinase signaling to Akt. (PubMed id 20957047)1 Siepmann M....Walter J. (2010)
    742. Role of the AKT pathway in microRNA expression of hum an U251 glioblastoma cells. (PubMed id 20126987)1 Zhou X....Kang C.S. (2010)
    743. Activated PI3K/Akt/COX-2 pathway induces resistance t o radiation in human cervical cancer HeLa cells. (PubMed id 20578837)1 Xia S....Zhang M. (2010)
    744. The time course of Akt and ERK activation on XIAP exp ression in HEK 293 cell line. (PubMed id 19649722)1 Abkhezr M....Ghahremani M.H. (2010)
    745. Differential roles of ERK and Akt pathways in regulat ion of EGFR-mediated signaling and motility in prostate cancer cells. (PubMed id 20562913)1 Gan Y....Huang Y. (2010)
    746. Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma. (PubMed id 20008098)1 Uddin S....Al-Kuraya K.S. (2010)
    747. Activation of the PI3K/AKT signalling pathway in non- melanoma skin cancer is not mediated by oncogenic PIK3CA and AKT1 hotspot mutat ions. (PubMed id 20557351)1 Hafner C....Vogt T. (2010)
    748. PDK1 recruitment to the SHPS-1 signaling complex enha nces insulin-like growth factor-i-stimulated AKT activation and vascular smooth muscle cell survival. (PubMed id 20643654)1 Shen X....Clemmons D.R. (2010)
    749. NSAID sulindac and its analog bind RXRalpha and inhib it RXRalpha-dependent AKT signaling. (PubMed id 20541701)1 Zhou H....Zhang X.K. (2010)
    750. Expression analysis of Akt and MAPK signaling pathway s in lung tissue of patients with idiopathic pulmonary fibrosis (IPF). (PubMed id 20536315)1 Antoniou K.M....Siafakas N.M. (2010)
    751. Shear stress activates Akt during vascular smooth mus cle cell reorientation. (PubMed id 20055757)1 Rice K.M....Blough E.R. (2010)
    752. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    753. PI3K/Akt signaling mediated apoptosis blockage and vi ral gene expression in oral epithelial cells during herpes simplex virus infect ion. (PubMed id 20620179)1 Hsu M.J....Hung S.L. (2010)
    754. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)1 Ban H.J....Park K.J. (2010)
    755. AKT loss in human epithelial cells treated with sever e hypoxia. (PubMed id 20347887)1 Box A.H....Demetrick D.J. (2010)
    756. Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy co ntrols. (PubMed id 20921115)1 Nicodemus K.K....Weinberger D.R. (2010)
    757. Insulin-like growth factor 1 receptor antibody induce s rhabdomyosarcoma cell death via a process involving AKT and Bcl-x(L). (PubMed id 20818434)1 Mayeenuddin L.H....Cao L. (2010)
    758. Protein kinase B (AKT) mediates phospholipase D activ ation via ERK1/2 and promotes respiratory burst parameters in formylpeptide-sti mulated neutrophil-like HL-60 cells. (PubMed id 20693286)1 Patel S....PAcrianin A. (2010)
    759. Akt phosphorylation of deleted in liver cancer 1 abro gates its suppression of liver cancer tumorigenesis and metastasis. (PubMed id 20600027)1 Ko F.C....Yam J.W. (2010)
    760. Inhibition of the phosphatidylinositol 3-kinase-Akt p athway enhances gamma-2 herpesvirus lytic replication and facilitates reactivat ion from latency. (PubMed id 19864499)1 Peng L....Sun R. (2010)
    761. Caffeine confers radiosensitization of PTEN-deficient malignant glioma cells by enhancing ionizing radiation-induced G1 arrest and n egatively regulating Akt phosphorylation. (PubMed id 20103602)1 Sinn B....Tinhofer I. (2010)
    762. Amphiregulin regulates the activation of ERK and Akt through epidermal growth factor receptor and HER3 signals involved in the progr ession of pancreatic cancer. (PubMed id 20726858)1 Yotsumoto F....Miyamoto S. (2010)
    763. Serum and glucocorticoid-induced kinase (SGK) 1 and t he epithelial sodium channel are regulated by multiple with no lysine (WNK) fam ily members. (PubMed id 20525693)1 Heise C.J....Cobb M.H. (2010)
    764. gp120 modulates the biology of human hepatic stellate cells: a link between HIV infection and liver fibrogenesis. (PubMed id 19736361)1 Bruno R....Marra F. (2010)
    765. Discovery of pyrrolopyrimidine inhibitors of Akt. (PubMed id 20810279)2 Blake J.F.... Brandhuber B.J. (2010)
    766. [The effect of angiotensin II on phosphoinositide-3 k inase/Akt cascade in cultured fibroblasts derived from patients with hypertroph ic scars] (PubMed id 20432929)1 Liu H.W....Liu W.Z. (2010)
    767. Family-Based Analysis of Genetic Variation Underlying Psychosis-Inducing Effects of Cannabis: Sibling Analysis and Proband Follow-up . (PubMed id 21041608)1 van Winkel R. (2010)
    768. Single-nucleotide polymorphisms in the p53 pathway ge nes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent. (PubMed id 20306497)1 Yarden R.I....Papa M.Z. (2010)
    769. Glycolytic phenotype in breast cancer: activation of Akt, up-regulation of GLUT1, TKTL1 and down-regulation of M2PK. (PubMed id 19655166)1 Schmidt M....Kammerer U. (2010)
    770. Molecular, morphologic, and outcome analysis of thyro id carcinomas according to degree of extrathyroid extension. (PubMed id 20860430)1 Rivera M....Ghossein R. (2010)
    771. Downregulation of HtrA1 promotes resistance to anoiki s and peritoneal dissemination of ovarian cancer cells. (PubMed id 20388781)1 He X....Shridhar V. (2010)
    772. P53 and p38 MAPK pathways are involved in MONCPT-indu ced cell cycle G2/M arrest in human non-small cell lung cancer A549. (PubMed id 19727814)1 Zhang C....Yang B. (2010)
    773. Akt is activated in chronic lymphocytic leukemia cell s and delivers a pro-survival signal: the therapeutic potential of Akt inhibiti on. (PubMed id 19713228)1 Zhuang J....Pettitt A.R. (2010)
    774. IQGAP1 is overexpressed in hepatocellular carcinoma a nd promotes cell proliferation by Akt activation. (PubMed id 20530982)1 Chen F....Chen Z. (2010)
    775. Inhibition of protein kinase Akt1 by apoptosis signal -regulating kinase-1 (ASK1) is involved in apoptotic inhibition of regulatory v olume increase. (PubMed id 20048146)1 Subramanyam M....Okada Y. (2010)
    776. Heat shock cognate protein 70 is essential for Akt si gnaling in endothelial function. (PubMed id 20018937)1 Shiota M....Iwao H. (2010)
    777. Protein kinase B (PKB/c-akt) regulates homing of hema topoietic progenitors through modulation of their adhesive and migratory proper ties. (PubMed id 20566894)1 Buitenhuis M....Coffer P.J. (2010)
    778. Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-li ke inhibitory protein. (PubMed id 19802016)1 Abedini M.R....Tsang B.K. (2010)
    779. Osteopontin induces beta-catenin signaling through ac tivation of Akt in prostate cancer cells. (PubMed id 19850036)1 Robertson B.W. and Chellaiah M.A. (2010)
    780. Clinical significance of PTEN and p-Akt co-expression in HER2-positive metastatic breast cancer patients treated with trastuzumab-ba sed therapies. (PubMed id 20389136)1 Fabi A....Mottolese M. (2010)
    781. Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (2010)
    782. Mutation analysis of tumor suppressor gene PTEN in pa tients with gastric carcinomas and its impact on PI3K/AKT pathway. (PubMed id 20514448)1 Wen Y.G....Tang H.M. (2010)
    783. Hierarchical clustering of immunohistochemical analys is of the activated ErbB/PI3K/Akt/NF-kappaB signalling pathway and prognostic s ignificance in prostate cancer. (PubMed id 20216540)1 Koumakpayi I.H....Saad F. (2010)
    784. UVB-induced ERK/AKT-dependent PTEN suppression promot es survival of epidermal keratinocytes. (PubMed id 19881543)1 Ming M....He Y.Y. (2010)
    785. BDNF-Akt-Bcl2 antiapoptotic signaling pathway is comp romised in the brain of autistic subjects. (PubMed id 20648653)1 Sheikh A.M....Li X. (2010)
    786. Protein phosphatase-1 regulates Akt1 signal transduct ion pathway to control gene expression, cell survival and differentiation. (PubMed id 20186153)1 Xiao L....Li D.W. (2010)
    787. Akt isoforms regulate intermediate filament protein l evels in epithelial carcinoma cells. (PubMed id 20109457)1 Fortier A.M....Cadrin M. (2010)
    788. Hypoxia switches glucose depletion-induced necrosis t o phosphoinositide 3-kinase/Akt-dependent apoptosis in A549 lung adenocarcinoma cells. (PubMed id 19956840)1 Kim C.H....Kang H.S. (2010)
    789. TNFalpha induced oxidative stress dependent Akt signa ling affects actin cytoskeletal organization in glioma cells. (PubMed id 19836430)1 Ghosh S....Sen E. (2010)
    790. Higher pAkt expression predicts a significant worse p rognosis in glioblastomas. (PubMed id 20410674)1 Suzuki Y....Nakano T. (2010)
    791. Transcriptional and post-transcriptional control of D NA methyltransferase 3B is regulated by phosphatidylinositol 3 kinase/Akt pathw ay in human hepatocellular carcinoma cell lines. (PubMed id 20506537)1 Mei C....Zha X. (2010)
    792. COX-2 activation is associated with Akt phosphorylati on and poor survival in ER-negative, HER2-positive breast cancer. (PubMed id 21078168)1 Glynn S.A....Ambs S. (2010)
    793. Evaluation of the mTOR pathway in ocular (uvea and co njunctiva) melanoma. (PubMed id 20173664)1 PA^pulo H....Lopes J.M. (2010)
    794. PKB/AKT phosphorylation of the transcription factor T wist-1 at Ser42 inhibits p53 activity in response to DNA damage. (PubMed id 20400976)1 Vichalkovski A....Hemmings B.A. (2010)
    795. Chronic myeloid leukemia and BCR/ABL signal pathways are not associated with AKT1 pleckstrin homology domain (E17K) mutations. (PubMed id 19744127)1 He Y....Huang S. (2010)
    796. Shepherding AKT and androgen receptor by Ack1 tyrosin e kinase. (PubMed id 20432460)1 Mahajan K. and Mahajan N.P. (2010)
    797. Enhanced MCP-1 release by keloid CD14+ cells augments fibroblast proliferation: role of MCP-1 and Akt pathway in keloids. (PubMed id 20100200)1 Liao W.T....Lee C.H. (2010)
    798. Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines. (PubMed id 19070520)1 Wallerand H....Reiter R.R. (2010)
    799. Myricetin inhibits Akt survival signaling and induces Bad-mediated apoptosis in a low dose ultraviolet (UV)-B-irradiated HaCaT human immortalized keratinocytes. (PubMed id 20339252)1 Kim W....Youn B. (2010)
    800. Notch-activated signaling cascade interacts with mito chondrial remodeling proteins to regulate cell survival. (PubMed id 20339081)1 Perumalsamy L.R....Sarin A. (2010)
    801. Inositol polyphosphate 4-phosphatase II regulates PI3 K/Akt signaling and is lost in human basal-like breast cancers. (PubMed id 21127264)1 Fedele C.G....Mitchell C.A. (2010)
    802. Genetic variation in a metabolic signaling pathway an d colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. (PubMed id 20622004)1 Slattery M.L....Wolff R.K. (2010)
    803. Prostaglandin E2 induces CYP1B1 expression via ligand -independent activation of the ERalpha pathway in human breast cancer cells. (PubMed id 20093341)1 Han E.H....Jeong H.G. (2010)
    804. Genetic Risk Factors for Hepatopulmonary Syndrome in Patients With Advanced Liver Disease. (PubMed id 20346360)1 Roberts K.E....Fallon M.B. (2010)
    805. [Activities of Akt pathway and their correlation with pathological changes in myotonic dystrophy]. (PubMed id 20957008)1 Li X....Yuan Y. (2010)
    806. Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases. (PubMed id 19833727)1 Humphrey R.K....Jhala U.S. (2010)
    807. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1 He C....Hunter D.J. (2010)
    808. Syrbactin class proteasome inhibitor-induced apoptosi s and autophagy occurs in association with p53 accumulation and Akt/PKB activat ion in neuroblastoma. (PubMed id 20362557)1 Archer C.R....Bachmann A.S. (2010)
    809. PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-ba sed chemotherapy. (PubMed id 20447721)1 Pu X....Wu X. (2010)
    810. AKT1 polymorphisms are associated with risk for metab olic syndrome. (PubMed id 21061022)1 Devaney J.M....Hoffman E.P. (2010)
    811. Overexpression of Par-4 sensitizes TRAIL-induced apop tosis via inactivation of NF-kappaB and Akt signaling pathways in renal cancer cells. (PubMed id 20127709)1 Lee T.J....Kwon T.K. (2010)
    812. PTEN/pAkt/p53 signaling pathway correlates with the r adioresponse of non-small cell lung cancer. (PubMed id 20198299)1 Jung I.L....Kim I.G. (2010)
    813. Inhibition of activated phosphatidylinositol 3-kinase /AKT pathway in malignant pleural mesothelioma leads to G1 cell cycle arrest. (PubMed id 21042767)1 Mikami I....He B. (2010)
    814. Constitutively nuclear FOXO3a localization predicts p oor survival and promotes Akt phosphorylation in breast cancer. (PubMed id 20808831)1 Chen J....Khoo U.S. (2010)
    815. Small-molecule inhibitors of phosphatidylinositol 3-k inase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress me dulloblastoma growth. (PubMed id 20028853)1 Baryawno N....Johnsen J.I. (2010)
    816. Inhibition of Akt signaling by exclusion from lipid r afts in normal and transformed epidermal keratinocytes. (PubMed id 20054340)1 Calay D....Gniadecki R. (2010)
    817. The clinicopathological and prognostic relevance of p yruvate kinase M2 and pAkt expression in breast cancer. (PubMed id 20592362)1 Benesch C....Schmidt M. (2010)
    818. Staged stromal extracellular 3D matrices differential ly regulate breast cancer cell responses through PI3K and beta1-integrins. (PubMed id 19323811)1 CastellA^-Cros R....Cukierman E. (2009)
    819. Controversies in breast cancer: the mammalian target of rapamycin as a target for breast cancer therapy. (PubMed id 20030877)1 Di Cosimo S. (2009)
    820. beta-arrestin2 inhibits opioid-induced breast cancer cell death through Akt and caspase-8 pathways. (PubMed id 19239323)1 Zhao M....Yin D. (2009)
    821. Semaphorin 4D signaling requires the recruitment of p hospholipase C gamma into the plexin-B1 receptor complex. (PubMed id 19805522)1 Swiercz J.M....Offermanns S. (2009)
    822. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)1 GregA^rio S.P....Dias-Neto E. (2009)
    823. Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells. (PubMed id 19723094)1 Lee Y.K....Park O.J. (2009)
    824. KAI1/CD82 decreases Rac1 expression and cell proliferation through PI3K/Akt/mTOR pathway in H1299 lung carcinoma cells. (PubMed id 19107873)1 Choi U.J....Lee K.H. (2009)
    825. Hypoxia increases normal prostate epithelial cell resistance to receptor-mediated apoptosis via AKT activation. (PubMed id 19142871)1 Walsh S....Watson R.W. (2009)
    826. The level of AKT phosphorylation on threonine 308 but not on serine 473 is associated with high-risk cytogenetics and predicts poor overall survival in acute myeloid leukaemia. (PubMed id 19158829)1 Gallay N....RAccher C. (2009)
    827. Immunological synapse formation inhibits, via NF-kapp aB and FOXO1, the apoptosis of dendritic cells. (PubMed id 19503105)1 Riol-Blanco L....RodrA-guez-FernA!ndez J.L. (2009)
    828. Immuno-analysis of phospho-Akt in primary human breas t cancers. (PubMed id 19787271)1 Al-Bazz Y.O....Dobson P.R. (2009)
    829. PI3 kinase/Akt signaling mediates epithelial-mesenchymal transition in hypoxic hepatocellular carcinoma cells. (PubMed id 19303863)1 Yan W....Luo M. (2009)
    830. Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leu kemia cell proliferation through continuous phosphorylation of Akt isoforms. (PubMed id 19261608)1 Hirano I....Ohnishi K. (2009)
    831. Retinoic acid-induced nNOS expression depends on a no vel PI3K/Akt/DAX1 pathway in human TGW-nu-I neuroblastoma cells. (PubMed id 19726747)1 Nagl F....Saur D. (2009)
    832. CCL2 is a negative regulator of AMP-activated protein kinase to sustain mTOR complex-1 activation, survivin expression, and cell sur vival in human prostate cancer PC3 cells. (PubMed id 20019839)1 Roca H....Pienta K.J. (2009)
    833. High frequency of PTEN, PI3K, and AKT abnormalities i n T-cell acute lymphoblastic leukemia. (PubMed id 19458356)1 Gutierrez A....Look A.T. (2009)
    834. Overexpressing PKIB in prostate cancer promotes its a ggressiveness by linking between PKA and Akt pathways. (PubMed id 19483721)1 Chung S....Nakagawa H. (2009)
    835. Promising molecular targets in ovarian cancer. (PubMed id 19553815)1 Blagden S. and Gabra H. (2009)
    836. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1 Shen M....Lan Q. (2009)
    837. [Effects of SHIP gene mutation on cell cycle related proteins and phosphorylated Akt in K562 cells] (PubMed id 19954644)1 Yang L....Zhang J.Y. (2009)
    838. (-)-Epigallocatechin-3-gallate (EGCG) increases the v iability of serum-starved A549 cells through its effect on Akt. (PubMed id 19655410)1 Kim M.J....Park H.R. (2009)
    839. Cyclin D1 induction by benzo[a]pyrene-7,8-diol-9,10-e poxide via the phosphatidylinositol 3-kinase/Akt/MAPK- and p70s6k-dependent pat hway promotes cell transformation and tumorigenesis. (PubMed id 19801633)1 Ding J....Wang H. (2009)
    840. Activation of phosphatidylinositol-3'-kinase/AKT sign aling is essential in hepatoblastoma survival. (PubMed id 19584164)1 Hartmann W....Pietsch T. (2009)
    841. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1 Yerges L.M....Zmuda J.M. (2009)
    842. The TRbeta1 is essential in mediating T3 action on Ak t pathway in human pancreatic insulinoma cells. (PubMed id 19160403)1 Verga Falzacappa C....Misiti S. (2009)
    843. Stathmin, a microtubule regulatory protein, is associated with hypoxia-inducible factor-1alpha levels in human endometrial and endothelial cells. (PubMed id 19179443)1 Yoshie M....Tamura K. (2009)
    844. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
    845. ROS-driven Akt dephosphorylation at Ser-473 is involv ed in 4-HPR-mediated apoptosis in NB4 cells. (PubMed id 19482076)1 Cao J....Yang B. (2009)
    846. Calreticulin promotes cell motility and enhances resi stance to anoikis through STAT3-CTTN-Akt pathway in esophageal squamous cell ca rcinoma. (PubMed id 19684620)1 Du X.L....Wang M.R. (2009)
    847. Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism. (PubMed id 19435822)1 Shin S....Reddy S.A. (2009)
    848. Activation of phosphatidylinositol 3-kinase/protein k inase B by corticotropin-releasing factor in human monocytes. (PubMed id 19628576)1 Chandras C....Karalis K.P. (2009)
    849. Human immunodeficiency virus type 1 Tat accelerates K aposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transf ormed fibroblasts in vitro as well as in nude and immunocompetent mice. (PubMed id 20019835)1 Chen X....Lu C. (2009)
    850. Essential roles of mTOR/Akt pathway in Aurora-A cell transformation. (PubMed id 19564927)1 Taga M....Ouchi T. (2009)
    851. Inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of NADPH oxidase inhibition but by lipid raft-dependent stimulation of Akt. (PubMed id 19095734)1 Remijsen Q....Willems J. (2009)
    852. Profilin-1 overexpression upregulates PTEN and suppresses AKT activation in breast cancer cells. (PubMed id 18937284)1 Das T....Roy P. (2009)
    853. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    854. Sustained activation of Akt and Erk1/2 is required for Coxiella burnetii antiapoptotic activity. (PubMed id 18981248)1 Voth D.E. and Heinzen R.A. (2009)
    855. Signaling pathways in adenoid cystic cancers: implica tions for treatment. (PubMed id 19729990)1 Gupta A.K....Robinson R.A. (2009)
    856. Telmisartan induces proliferation of human endothelia l progenitor cells via PPARgamma-dependent PI3K/Akt pathway. (PubMed id 19193378)1 Honda A....Hagiwara N. (2009)
    857. Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. (PubMed id 19270695)1 Gao D....Wei W. (2009)
    858. Butein suppresses c-Myc-dependent transcription and A kt-dependent phosphorylation of hTERT in human leukemia cells. (PubMed id 19560862)1 Moon D.O....Kim G.Y. (2009)
    859. Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK. (PubMed id 19885574)1 Shin D.Y....Choi Y.H. (2009)
    860. AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells. (PubMed id 19377290)1 Lal M.A....Ceryak S. (2009)
    861. Absence of oncogenic AKT1 E17K mutation in prostate, esophageal, laryngeal and urothelial carcinomas, hepatoblastomas, gastrointesti nal stromal tumors and malignant meningiomas. (PubMed id 19353338)1 Eom H.S....Lee S.H. (2009)
    862. Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway. (PubMed id 18996844)1 Nakayama M....Hirayama T. (2009)
    863. Structure-Function analysis of the CTLA-4 interaction with PP2A. (PubMed id 19405949)1 Teft W.A....Madrenas J. (2009)
    864. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1 Hosgood H.D....Lan Q. (2009)
    865. Integrin-linked kinase is required for vitronectin-mediated internalization of Streptococcus pneumoniae by host cells. (PubMed id 19118218)1 Bergmann S....Hammerschmidt S. (2009)
    866. PI3K/Akt inhibition modulates multidrug resistance and activates NF-kappaB in murine lymphoma cell lines. (PubMed id 18640717)1 GarcA-a M.G....Hajos S.E. (2009)
    867. The myxoma virus m-t5 ankyrin repeat host range prote in is a novel adaptor that coordinately links the cellular signaling pathways m ediated by Akt and Skp1 in virus-infected cells. (PubMed id 19776120)1 Werden S.J....McFadden G. (2009)
    868. Id-1 activates Akt-mediated Wnt signaling and p27(Kip1) phosphorylation through PTEN inhibition. (PubMed id 19079342)1 Lee J.Y....Kong G. (2009)
    869. Cdc42 and the phosphatidylinositol 3-kinase-Akt pathw ay are essential for PspC-mediated internalization of pneumococci by respirator y epithelial cells. (PubMed id 19473971)1 Agarwal V. and Hammerschmidt S. (2009)
    870. Wortmannin inhibits K562 leukemic cells by regulating PI3k/Akt channel in vitro. (PubMed id 19662361)1 Wu Q....Cheng Y. (2009)
    871. Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity. (PubMed id 19103742)1 Maddika S....Los M. (2009)
    872. Aberrant overexpression of microRNAs activate AKT sig naling via down-regulation of tumor suppressors in natural killer-cell lymphoma /leukemia. (PubMed id 19641183)1 Yamanaka Y....Sawada K. (2009)
    873. Platelet lysate promotes in vitro wound scratch closu re of human dermal fibroblasts: different roles of cell calcium, P38, ERK and P I3K/AKT. (PubMed id 19267882)1 Ranzato E....Burlando B. (2009)
    874. Upregulated expression of periostin by hypoxia in non -small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway. (PubMed id 19328625)1 Ouyang G....Bao S. (2009)
    875. Chemokine coreceptor signaling in HIV-1 infection and pathogenesis. (PubMed id 20041213)1 Wu Y. and Yoder A. (2009)
    876. Overexpression of leptin receptor predicts an unfavor able outcome in Middle Eastern ovarian cancer. (PubMed id 19765303)1 Uddin S....Al-Kuraya K.S. (2009)
    877. Integrin-linked kinase: a multi-functional regulator modulating extracellular pressure-stimulated cancer cell adhesion through focal adhesion kinase and AKT. (PubMed id 19633364)1 Wang S. and Basson M.D. (2009)
    878. Akt/protein kinase B overexpression as an accurate pr ognostic marker in adult diffuse astrocytoma. (PubMed id 19240976)1 Matsutani T....Iwadate Y. (2009)
    879. An Akt/hypoxia-inducible factor-1alpha/platelet-deriv ed growth factor-BB autocrine loop mediates hypoxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells. (PubMed id 19447872)1 Lau C.K....Fan S.T. (2009)
    880. Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines. (PubMed id 19091404)1 Guo D....Ji C. (2009)
    881. The augmented anti-tumor effects of Antrodia camphora ta co-fermented with Chinese medicinal herb in human hepatoma cells. (PubMed id 19655414)1 Li S.L....Chuu J.J. (2009)
    882. The suppression of MAD1 by AKT-mediated phosphorylati on activates MAD1 target genes transcription. (PubMed id 19526459)1 Chou C.K....Hung M.C. (2009)
    883. The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis. (PubMed id 19068483)1 Wang W....Boss G.R. (2009)
    884. Celastrol binds to ERK and inhibits FcepsilonRI signa ling to exert an anti-allergic effect. (PubMed id 19356729)1 Kim Y....Jeoung D. (2009)
    885. Aurora-A down-regulates IkappaBalpha via Akt activati on and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival. (PubMed id 19891769)1 Yao J.E....Liu Q. (2009)
    886. Regulation of mammary stem/progenitor cells by PTEN/A kt/beta-catenin signaling. (PubMed id 19492080)1 Korkaya H....Wicha M.S. (2009)
    887. [Activation and clinicopathologic significance of AKT /mTOR signaling pathway in diffuse large B-cell lymphoma] (PubMed id 19489223)1 Yu B.H....Shi D.R. (2009)
    888. Akt regulates vitamin D3-induced leukemia cell functional differentiation via Raf/MEK/ERK MAPK signaling. (PubMed id 19058874)1 Wang J....Lian H. (2009)
    889. Akt and 14-3-3 control a PACS-2 homeostatic switch th at integrates membrane traffic with TRAIL-induced apoptosis. (PubMed id 19481529)1 Aslan J.E....Thomas G. (2009)
    890. Peptidoglycan enhances IL-6 production in human synov ial fibroblasts via TLR2 receptor, focal adhesion kinase, Akt, and AP-1- depend ent pathway. (PubMed id 19635908)1 Chiu Y.C....Tang C.H. (2009)
    891. A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways. (PubMed id 19767770)1 Mamidipudi V. and Cartwright C.A. (2009)
    892. Phosphatidylinositol 3-kinase/Akt pathway regulates i nflammatory mediators-induced calcification of human vascular smooth muscle cel ls. (PubMed id 20088406)1 Okazaki H....Nishizawa Y. (2009)
    893. Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis. (PubMed id 18495460)1 Vejux A....Lizard G. (2009)
    894. [Inhibitory effect of lentiviral vector-mediated SHIP gene transfection on proliferation of leukemia K562 cells and PI3K/Akt pathway regulation.] (PubMed id 19622295)1 Yang L....Yao L. (2009)
    895. Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells. (PubMed id 19074768)1 Minhajuddin M....Rahman A. (2009)
    896. Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells. (PubMed id 20042122)1 Chua B.T....Downward J. (2009)
    897. An absence of stromal caveolin-1 is associated with a dvanced prostate cancer, metastatic disease and epithelial Akt activation. (PubMed id 19556867)1 Di Vizio D....Lisanti M.P. (2009)
    898. The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors. (PubMed id 19098000)1 Harada H....Hiraoka M. (2009)
    899. The phosphatidylinositol 3-kinase/Akt pathway regulat es transforming growth factor-{beta} signaling by destabilizing ski and inducin g Smad7. (PubMed id 19875456)1 Band A.M....Laiho M. (2009)
    900. Hydrogen peroxide-induced Akt phosphorylation regulat es Bax activation. (PubMed id 19278624)1 Sadidi M....Feldman E.L. (2009)
    901. Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulat ed by phosphorylation. (PubMed id 19667065)1 Polzien L....Rapp U.R. (2009)
    902. Prognostic value of Akt-1 in human prostate cancer: a computerized quantitative assessment with quantum dot technology. (PubMed id 19417030)1 Li R....Ayala G.E. (2009)
    903. Magnolol induces apoptosis via inhibiting the EGFR/PI 3K/Akt signaling pathway in human prostate cancer cells. (PubMed id 19229860)1 Lee D.H....Lee Y.J. (2009)
    904. Low density lipoprotein receptor-related protein 1 pr omotes anti-apoptotic signaling in neurons by activating Akt survival pathway. (PubMed id 19815552)1 Fuentealba R.A....Bu G. (2009)
    905. Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression. (PubMed id 18790560)1 Al-Salihi M.A....Topham M.K. (2009)
    906. Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1. (PubMed id 19479902)1 Demers M.J....Vachon P.H. (2009)
    907. Involvement of Akt1/protein kinase Balpha in tumor co nditioned medium-induced endothelial cell migration and survival in vitro. (PubMed id 19488783)1 Tu M.L....Li D.S. (2009)
    908. Inside life of melanoma cell signaling, molecular ins ights, and therapeutic targets. (PubMed id 19679016)1 Sosman J.A. and Margolin K.A. (2009)
    909. S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIV ATION, AND TUMOR GROWTH. (PubMed id 19147496)1 Brozzi F....Donato R. (2009)
    910. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1 RuaA+o G....Hanks S. (2009)
    911. Osteopontin induces angiogenesis through activation o f PI3K/AKT and ERK1/2 in endothelial cells. (PubMed id 19597469)1 Dai J....Guo Y. (2009)
    912. PI3K/AKT mediated p53 down-regulation participates in CpG DNA inhibition of spontaneous B cell apoptosis. (PubMed id 19567200)1 Zhou Y....Fu X. (2009)
    913. c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms. (PubMed id 19262695)1 Lodeiro M....CamiA+a J.P. (2009)
    914. EGFR signals to mTOR through PKC and independently of Akt in glioma. (PubMed id 19176518)1 Fan Q.W....Weiss W.A. (2009)
    915. The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer. (PubMed id 19240722)1 Trinh X.B....van Dam P.A. (2009)
    916. PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. (PubMed id 19203586)1 Kawase T.... Taya Y. (2009)
    917. Ceramide mediates inhibition of the AKT/eNOS signalin g pathway by palmitate in human vascular endothelial cells. (PubMed id 19721393)1 Xiao-Yun X....An-Hua L. (2009)
    918. Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C. (PubMed id 19324870)1 Brognard J....Newton A.C. (2009)
    919. Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 expression. (PubMed id 18844239)1 Cabodi S....Defilippi P. (2009)
    920. Genetic variations in PI3K-AKT-mTOR pathway and bladd er cancer risk. (PubMed id 19875696)1 Chen M....Wu X. (2009)
    921. Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via ph osphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway. (PubMed id 19801684)1 Koshikawa N....Takenaga K. (2009)
    922. Apoptotic body engulfment by hepatic stellate cells p romotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways. (PubMed id 19457567)1 Jiang J.X....TAPrAPk N.J. (2009)
    923. TGF-beta induces degradation of TAL1/SCL by the ubiqu itin-proteasome pathway through AKT-mediated phosphorylation. (PubMed id 19406989)1 Terme J.M....Jalinot P. (2009)
    924. A novel variant of ER-alpha, ER-alpha36 mediates test osterone-stimulated ERK and Akt activation in endometrial cancer Hec1A cells. (PubMed id 19775474)1 Lin S.L....Sun Q.Y. (2009)
    925. Elevated levels of IL-1beta in Fanconi anaemia group A patients due to a constitutively active phosphoinositide 3-kinase-Akt pathway are capable of promoting tumour cell proliferation. (PubMed id 19473116)1 IbA!A+ez A....PipaA^n C. (2009)
    926. 7-(O)-Carboxymethyl daidzein conjugated to N-t-Boc-he xylenediamine: a novel compound capable of inducing cell death in epithelial ov arian cancer stem cells. (PubMed id 19738422)1 Green J.M....Mor G. (2009)
    927. PTEN/AKT pathway involved in histone deacetylases inh ibitor induced cell growth inhibition and apoptosis of oral squamous cell carci noma cells. (PubMed id 19574087)1 Gan Y.H. and Zhang S. (2009)
    928. [Change from inflammation to carcinoma in ukcerative colitis: the role of PTEN/PI3K/AKT] (PubMed id 20067111)1 Fu D.G....Zhao L.Q. (2009)
    929. Suppression of p38 MAPK and JNK via Akt-mediated inhi bition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypept ide. (PubMed id 19748889)1 Widenmaier S.B....McIntosh C.H. (2009)
    930. Trypanosoma cruzi targets Akt in host cells as an int racellular antiapoptotic strategy. (PubMed id 19920252)1 Chuenkova M.V. and PereiraPerrin M. (2009)
    931. Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro. (PubMed id 19270310)1 Ermak G....Davies K.J. (2009)
    932. IL-6 cytoprotection in hyperoxic acute lung injury oc curs via PI3K/Akt-mediated Bax phosphorylation. (PubMed id 19376889)1 Kolliputi N. and Waxman A.B. (2009)
    933. Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase/Akt signalling pathway. (PubMed id 19029952)1 Shimwell N.J....Grand R.J. (2009)
    934. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. (PubMed id 19116273)1 Yang X.V....Griffin J.H. (2009)
    935. Influence of zinc deficiency on Akt-Mdm2-p53 and Akt- p21 signaling axes in normal and malignant human prostate cells. (PubMed id 19657064)1 Han C.T....Lei K.Y. (2009)
    936. Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway. (PubMed id 19261616)1 Chen K.F....Cheng A.L. (2009)
    937. Inhibition of PI3K-AKT-mTOR signaling sensitizes mela noma cells to cisplatin and temozolomide. (PubMed id 19078992)1 Sinnberg T....Meier F. (2009)
    938. Cell invasion of Yersinia pseudotuberculosis by invas in and YadA requires protein kinase C, phospholipase C-gamma1 and Akt kinase. (PubMed id 19681907)1 Uliczka F....Dersch P. (2009)
    939. DAB2IP coordinates both PI3K-Akt and ASK1 pathways fo r cell survival and apoptosis. (PubMed id 19903888)1 Xie D....Hsieh J.T. (2009)
    940. PTEN regulation by Akt-EGR1-ARF-PTEN axis. (PubMed id 19057511)1 Yu J....Mustelin T. (2009)
    941. Selective inhibition of prostaglandin E2 receptors EP 2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic a poptotic mechanisms. (PubMed id 19407222)1 Banu S.K....Arosh J.A. (2009)
    942. Insulin attenuates the insulin-like growth factor-I ( IGF-I)-Akt pathway, not IGF-I-extracellularly regulated kinase pathway, in lute inized granulosa cells with an increase in PTEN. (PubMed id 19318457)1 Iwase A....Kikkawa F. (2009)
    943. Genetic association studies of methamphetamine use disorders: A systematic review and synthesis. (PubMed id 19219857)1 Bousman C.A....Tsuang M.T. (2009)
    944. Lewis y antigen promotes the proliferation of ovarian carcinoma-derived RMG-I cells through the PI3K/Akt signaling pathway. (PubMed id 20003467)1 Liu J....Iwamori M. (2009)
    945. Dysregulated PI3K/Akt/PTEN pathway is a marker of a s hort disease-free survival in node-negative breast carcinoma. (PubMed id 19428048)1 Capodanno A....Collecchi P. (2009)
    946. Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas. (PubMed id 19276265)1 Han S....Ramesh V. (2009)
    947. [The relationship between PTEN expression and PI3K/AK T signal pathway in colon carcinoma] (PubMed id 19764563)1 Qi J.K....Fu D.G. (2009)
    948. The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations. (PubMed id 19116269)1 Dubrovska A....Reddy V.A. (2009)
    949. Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway. (PubMed id 19250936)1 Mattioli B....Viora M. (2009)
    950. KiSS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to Akt, tumor necrosis factor family ligand expression, and apoptosis. (PubMed id 19201817)1 Navenot J.M....Peiper S.C. (2009)
    951. Toll-like receptor 4 activation increases Akt phospho rylation in colon cancer cells. (PubMed id 19596916)1 Doan H.Q....Evers B.M. (2009)
    952. HIV-1 Tat co-operates with IFN-gamma and TNF-alpha to increase CXCL10 in human astrocytes. (PubMed id 19479051)1 Williams R....Buch S.J. (2009)
    953. Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T>C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin. (PubMed id 19219602)1 Kim J.G....Jun S.H. (2009)
    954. Akt inhibitors induce apoptosis in chronic lymphocyti c leukemia cells. (PubMed id 19815839)1 de Frias M....Gil J. (2009)
    955. Forskolin attenuates the action of insulin on the Akt -mTOR pathway in human skeletal muscle. (PubMed id 19935854)1 Richmond S.R....Gallagher P.M. (2009)
    956. Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids. (PubMed id 19286607)1 Singleton P.A....Birukov K.G. (2009)
    957. Tubulin acetylation favors Hsp90 recruitment to micro tubules and stimulates the signaling function of the Hsp90 clients Akt/PKB and p53. (PubMed id 19136058)1 Giustiniani J....Baillet A. (2009)
    958. Epidermal growth factor receptor regulates MT1-MMP an d MMP-2 synthesis in SiHa cells via both PI3-K/AKT and MAPK/ERK pathways. (PubMed id 19820359)1 Zhang Z....Li P. (2009)
    959. Differential expression of PTEN in normal adult rat brain and upregulation of PTEN and p-Akt in the ischemic cerebral cortex. (PubMed id 19142997)1 Cai Q.Y....Yao Z.X. (2009)
    960. MicroRNAs differentially regulated by Akt isoforms co ntrol EMT and stem cell renewal in cancer cells. (PubMed id 19825827)1 Iliopoulos D....Tsichlis P.N. (2009)
    961. Integrative predictive model of coronary artery calci fication in atherosclerosis. (PubMed id 19948975)1 McGeachie M....Ramoni M.F. (2009)
    962. Wortmannin potentiates roscovitine-induced growth inh ibition in human solid tumor cells by repressing PI3K/Akt pathway. (PubMed id 19541408)1 Zhang F....Mei Q. (2009)
    963. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. (PubMed id 19250983)1 Yan F....Polk D.B. (2009)
    964. Elongation Factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility . (PubMed id 19646290)1 Pecorari L....Calabretta B. (2009)
    965. DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif. (PubMed id 19144640)1 Park J....Hemmings B.A. (2009)
    966. Correlation between PTEN expression and PI3K/Akt signal pathway in endometrial carcinoma. (PubMed id 19224164)1 Gao Q....Ma D. (2009)
    967. FGFR2 is associated with hair thickness in Asian popu lations. (PubMed id 19590514)1 Fujimoto A....Ohashi J. (2009)
    968. Endothelin-1 and transforming growth factor-beta1 ind ependently induce fibroblast resistance to apoptosis via AKT activation. (PubMed id 19188658)1 Kulasekaran P....Horowitz J.C. (2009)
    969. Absence of AKT1 mutations in glioblastoma. (PubMed id 19461960)1 Bleeker F.E....Bardelli A. (2009)
    970. Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells. (PubMed id 19162005)1 Fosbrink M....Rus H. (2009)
    971. Regulation of a third conserved phosphorylation site in SGK1. (PubMed id 19068477)1 Chen W....Cobb M.H. (2009)
    972. Expression of phosphorylated Akt in oral carcinogenes is and its induction by nicotine and alkaline stimulation. (PubMed id 18331557)1 Wu H.T....Kao S.Y. (2009)
    973. Phosphatidylinositol 3-kinase/Akt pathway targets ace tylation of Smad3 through Smad3/CREB-binding protein interaction: contribution to transforming growth factor beta1-induced Epstein-Barr virus reactivation. (PubMed id 19589780)1 Oussaief L....Joab I. (2009)
    974. Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. (PubMed id 19270694)1 Lin H.K....Pandolfi P.P. (2009)
    975. PTEN regulates angiogenesis through PI3K/Akt/VEGF sig naling pathway in human pancreatic cancer cells. (PubMed id 19437103)1 Ma J....Takeyama H. (2009)
    976. Insulin enhances proliferation and viability of human umbilical vein endothelial cells. (PubMed id 19115062)1 Shrader C.D....Reilly F.D. (2009)
    977. Iron-saturated lactoferrin stimulates cell cycle prog ression through PI3K/Akt pathway. (PubMed id 19533041)1 Lee S.H....Choi S.Y. (2009)
    978. Function of Akt/PKB signaling to cell motility, invas ion and the tumor stroma in cancer. (PubMed id 19110052)1 Chin Y.R. and Toker A. (2009)
    979. The sodium-hydrogen exchanger NHE1 is an Akt substrat e necessary for actin filament reorganization by growth factors. (PubMed id 19622752)1 Meima M.E....Barber D.L. (2009)
    980. Ubiquitous mitochondrial creatine kinase is overexpre ssed in the conditioned medium and the extract of LNCaP lineaged androgen indep endent cell lines and facilitates prostate cancer progression. (PubMed id 19415690)1 Pang B....Zhou J.G. (2009)
    981. New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival. (PubMed id 18936167)1 Chabot C....Royal I. (2009)
    982. E-cadherin directly contributes to PI3K/AKT activation by engaging the PI3K-p85 regulatory subunit to adherens junctions of ovarian carcinoma cells. (PubMed id 19151754)1 De Santis G....Tomassetti A. (2009)
    983. Implications of Nef: host cell interactions in viral p ersistence and progression to AIDS. (PubMed id 20012528)1 Arhel N.J. and Kirchhoff F. (2009)
    984. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1 So H.C....Sham P.C. (2009)
    985. Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells. (PubMed id 19723095)1 Kim S.H....Song Y.S. (2009)
    986. Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activ ation of the EGFR/PI3K/AKT pathway. (PubMed id 19917135)1 Dong P....Feng Y. (2009)
    987. NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signalling pathway. (PubMed id 18924134)1 Stewart G.D....Habib F.K. (2009)
    988. A hypomorphic allele of Tsc2 highlights the role of T SC1/TSC2 in signaling to AKT and models mild human TSC2 alleles. (PubMed id 19357198)1 Pollizzi K....Kwiatkowski D.J. (2009)
    989. [A G-quadruplex ligand SYUIQ-5 induces autophagy by i nhibiting the Akt-FOXO3a pathway in nasopharyngeal cancer cells] (PubMed id 19799812)1 Zhou W.J....Zhu X.F. (2009)
    990. Activation of the AKT/mTOR pathway in autosomal recessive polycystic kidney disease (ARPKD). (PubMed id 19176689)1 Fischer D.C....Haffner D. (2009)
    991. Adherens junction-dependent PI3K/Akt activation induces resistance to genotoxin-induced cell death in differentiated intestinal epithelial cells. (PubMed id 19059380)1 Chae B....Kim W.H. (2009)
    992. QLT0267, a small molecule inhibitor targeting integri n-linked kinase (ILK), and docetaxel can combine to produce synergistic interac tions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-ac tin architecture and improved treatment outcomes in an orthotopic breast cancer model. (PubMed id 19409087)1 Kalra J....Bally M. (2009)
    993. beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt. (PubMed id 19797085)1 Li X....Gao T. (2009)
    994. Metallothionein and p-Akt proteins in oral dysplasia and in oral squamous cell carcinoma: an immunohistochemical study. (PubMed id 19453843)1 Pontes H.A....dos Santos Pinto D. (2009)
    995. Chronic hypoxia activates the Akt and beta-catenin pa thways in human macrophages. (PubMed id 19644051)1 Deguchi J.O....Aikawa M. (2009)
    996. Role of phosphoinositide 3-kinase beta in glycoprotei n VI-mediated Akt activation in platelets. (PubMed id 19700402)1 Kim S....Kunapuli S.P. (2009)
    997. CCL5 increases lung cancer migration via PI3K, Akt and NF-kappaB pathways. (PubMed id 19073147)1 Huang C.Y....Tang C.H. (2009)
    998. Protein phosphatase 2Cgamma regulates the level of p2 1Cip1/WAF1 by Akt signaling. (PubMed id 19538940)1 Suh E.J....Kim S.H. (2009)
    999. Increased activated Akt expression in renal cell carc inomas and prognosis. (PubMed id 18774962)1 Hager M....Kolbitsch C. (2009)
    1000. Inhibition of PI3 kinase/Akt pathway is required for BMP2-induced EMT and invasion. (PubMed id 19639199)1 Kang M.H....Yoo Y.A. (2009)
    1001. Helicobacter pylori activate epidermal growth factor receptor- and phosphatidylinositol 3-OH kinase-dependent Akt and glycogen synthase kinase 3beta phosphorylation. (PubMed id 18782353)1 Tabassam F.H....Yamaoka Y. (2009)
    1002. Cross talk initiated by endothelial cells enhances mi gration and inhibits anoikis of squamous cell carcinoma cells through STAT3/Akt /ERK signaling. (PubMed id 19484147)1 Neiva K.G....NAPr J.E. (2009)
    1003. Constitutively active Akt inhibits trafficking of amyloid precursor protein and amyloid precursor protein metabolites through feedback inhibition of phosphoinositide 3-kinase. (PubMed id 19236051)1 Shineman D.W....Lee V.M. (2009)
    1004. The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma. (PubMed id 19147772)1 Chung J.Y....Hewitt S.M. (2009)
    1005. TACE-mediated ectodomain shedding of the type I TGF-b eta receptor downregulates TGF-beta signaling. (PubMed id 19595713)1 Liu C....Derynck R. (2009)
    1006. RUNX1 regulates phosphoinositide 3-kinase/AKT pathway : role in chemotherapy sensitivity in acute megakaryocytic leukemia. (PubMed id 19638627)1 Edwards H....Ge Y. (2009)
    1007. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    1008. Absence of the AKT1 pleckstrin homology domain mutation in Japanese gastrointestinal and liver cancer patients. (PubMed id 19132987)1 Li Y....Omata M. (2008)
    1009. Protein kinase C epsilon confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53. (PubMed id 18317451)1 Shankar E....Basu A. (2008)
    1010. RGS13 controls g protein-coupled receptor-evoked responses of human mast cells. (PubMed id 19017978)1 Bansal G....Druey K.M. (2008)
    1011. Activated Akt as an indicator of prognosis in gastric cancer. (PubMed id 18841391)1 Cinti C....Tosi P. (2008)
    1012. No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. (PubMed id 18198266)1 Sanders A.R....Gejman P.V. (2008)
    1013. Induction of ErbB-3 expression by alpha6beta4 integrin contributes to tamoxifen resistance in ERbeta1-negative breast carcinomas. (PubMed id 18270579)1 Folgiero V....Falcioni R. (2008)
    1014. The early phase of programmed cell death in Caco-2 intestinal cells exposed to PTH. (PubMed id 18798227)1 Calvo N.G....de Boland A.R. (2008)
    1015. Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression. (PubMed id 17906677)1 Zhong J.C....Lin S.G. (2008)
    1016. Modulation of the activities of AMP-activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2-deoxyglucose. (PubMed id 18247380)1 Jiang W....Thompson H.J. (2008)
    1017. Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells. (PubMed id 18922901)1 Castro-Rivera E....Minna J.D. (2008)
    1018. Bidirectional actions of hydrogen peroxide on endothelial nitric-oxide synthase phosphorylation and function: co-commitment and interplay of Akt and AMPK. (PubMed id 18617528)1 Hu Z....Xia Y. (2008)
    1019. Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells. (PubMed id 18687691)1 Li Y....Sarkar F.H. (2008)
    1020. Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis. (PubMed id 18650932)1 Joshi J....Diaz-Meco M.T. (2008)
    1021. HTLV-I production based on activation of integrin/ligand signaling in HTLV-I-infected T cell lines derived from HAM/TSP patients. (PubMed id 18552504)1 Fukushima N....Eguchi K. (2008)
    1022. v-Crk induces Rac-dependent membrane ruffling and cell migration in CAS-deficient embryonic fibroblasts. (PubMed id 18319625)1 Sung B.H....Song W.K. (2008)
    1023. Carbon nanoparticle-induced lung epithelial cell proliferation is mediated by receptor-dependent Akt activation. (PubMed id 18083769)1 Unfried K....Abel J. (2008)
    1024. Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion. (PubMed id 18187454)1 Fournier A.K..