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Aliases for AKR7L Gene

Aliases for AKR7L Gene

  • Aldo-Keto Reductase Family 7-Like (Gene/Pseudogene) 2 3
  • AKR7A4 3 4 6
  • AFAR3 3 4 6
  • AFB1 Aldehyde Reductase 3 3 4
  • Aldoketoreductase 7-Like 3 4
  • Aflatoxin B1 Aldehyde Reductase Member 4 3
  • Aldo-Keto Reductase Family 7 Pseudogene 3
  • Aldo-Keto Reductase Family 7-Like 2
  • EC 1.-.-.- 4
  • AFB1-AR 3 4
  • AFB1-AR3 3

External Ids for AKR7L Gene

Summaries for AKR7L Gene

Entrez Gene Summary for AKR7L Gene

  • This gene is one of three aldo-keto reductase genes that are present in a cluster on the p arm of chromosome 1. The encoded proteins are involved in the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It has been speculated that this family member encodes a selenoprotein, which includes a selenocysteine (Sec) residue in lieu of a UGA translational termination codon. However, there is no evidence that such a protein is produced in vivo. The alternative interpretation is that this family member is a duplicated pseudogene, and it is therefore represented as such in this Gene record. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]

GeneCards Summary for AKR7L Gene

AKR7L (Aldo-Keto Reductase Family 7-Like (Gene/Pseudogene)) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is KCNAB2.

UniProtKB/Swiss-Prot for AKR7L Gene

  • Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR7L Gene

Genomics for AKR7L Gene

Genomic Location for AKR7L Gene

Start:
19,265,982 bp from pter
End:
19,274,194 bp from pter
Size:
8,213 bases
Orientation:
Minus strand

Genomic View for AKR7L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKR7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR7L Gene

Regulatory Elements for AKR7L Gene

Proteins for AKR7L Gene

  • Protein details for AKR7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHP1-ARK74_HUMAN
    Recommended name:
    Aflatoxin B1 aldehyde reductase member 4
    Protein Accession:
    Q8NHP1
    Secondary Accessions:
    • Q5U614

    Protein attributes for AKR7L Gene

    Size:
    331 amino acids
    Molecular mass:
    36964 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AKR7L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKR7L Gene

Proteomics data for AKR7L Gene at MOPED

Post-translational modifications for AKR7L Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys208

Other Protein References for AKR7L Gene

No data available for DME Specific Peptides for AKR7L Gene

Domains for AKR7L Gene

Protein Domains for AKR7L Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ARK74_HUMAN
Family:
  • Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.:
    • Q8NHP1
genes like me logo Genes that share domains with AKR7L: view

No data available for Gene Families for AKR7L Gene

Function for AKR7L Gene

Molecular function for AKR7L Gene

UniProtKB/Swiss-Prot Function: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).

Enzyme Numbers (IUBMB) for AKR7L Gene

Gene Ontology (GO) - Molecular Function for AKR7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with AKR7L: view

miRNA for AKR7L Gene

miRTarBase miRNAs that target AKR7L

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AKR7L Gene

Localization for AKR7L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKR7L Gene COMPARTMENTS Subcellular localization image for AKR7L gene
Compartment Confidence
cytosol 3
mitochondrion 3
nucleus 1

Gene Ontology (GO) - Cellular Components for AKR7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with AKR7L: view

Pathways for AKR7L Gene

SuperPathways for AKR7L Gene

No Data Available

Interacting Proteins for AKR7L Gene

Selected Interacting proteins: Q8NHP1-ARK74_HUMAN for AKR7L Gene via I2D

Symbol External ID(s) Details
SH3GLB2

Gene Ontology (GO) - Biological Process for AKR7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with AKR7L: view

No data available for Pathways by source for AKR7L Gene

Compounds for AKR7L Gene

(4) HMDB Compounds for AKR7L Gene

Compound Synonyms Cas Number PubMed IDs
Aflatoxin B1
  • AFB1
1162-65-8
Aflatoxin B1 dialcohol
  • AFB1 dialcohol
Not Available
Selenium
  • selenium
7782-49-2
Selenocysteine
  • (2R)-2-amino-3-selanylpropanoate
3614-08-2
genes like me logo Genes that share compounds with AKR7L: view

Transcripts for AKR7L Gene

Unigene Clusters for AKR7L Gene

Aldo-keto reductase family 7-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKR7L Gene

No ASD Table

Relevant External Links for AKR7L Gene

GeneLoc Exon Structure for
AKR7L
ECgene alternative splicing isoforms for
AKR7L

Expression for AKR7L Gene

mRNA expression in normal human tissues for AKR7L Gene

mRNA differential expression in normal tissues according to GTEx for AKR7L Gene

This gene is overexpressed in Liver (14.7), Small Intestine - Terminal Ileum (6.4), Stomach (5.4), and Pancreas (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for AKR7L Gene

SOURCE GeneReport for Unigene cluster for AKR7L Gene Hs.662342

mRNA Expression by UniProt/SwissProt for AKR7L Gene

Q8NHP1-ARK74_HUMAN
Tissue specificity: Mainly expressed in uterus.
genes like me logo Genes that share expressions with AKR7L: view

Orthologs for AKR7L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AKR7L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AKR7A2 37
  • 37 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia AKR7L 37
  • 27 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 26 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 20 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii akr7a3 37
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 16 (a)
OneToMany
Species with no ortholog for AKR7L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKR7L Gene

ENSEMBL:
Gene Tree for AKR7L (if available)
TreeFam:
Gene Tree for AKR7L (if available)

Paralogs for AKR7L Gene

Paralogs for AKR7L Gene

Selected SIMAP similar genes for AKR7L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AKR7L: view

Variants for AKR7L Gene

Sequence variations from dbSNP and Humsavar for AKR7L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1418229 -- 19,272,092(-) tttta(G/T)tttta intron-variant
rs1418230 -- 19,272,083(-) TATTT(C/T)GAAAT intron-variant
rs1418231 -- 19,271,912(-) AGAGA(C/T)GGGGT intron-variant
rs1738015 -- 19,267,453(-) GCCCA(C/T)GGGGA nc-transcript-variant
rs1774085 -- 19,269,375(+) CCCTG(A/C)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKR7L Gene

Variant ID Type Subtype PubMed ID
nsv871933 CNV Loss 21882294
esv2744819 CNV Deletion 23290073
dgv25e199 CNV Deletion 23128226
esv26443 CNV Loss 19812545

Relevant External Links for AKR7L Gene

HapMap Linkage Disequilibrium report
AKR7L

Disorders for AKR7L Gene

Relevant External Links for AKR7L

Genetic Association Database (GAD)
AKR7L
genes like me logo Genes that share disorders with AKR7L: view

No data available for UniProtKB/Swiss-Prot for AKR7L Gene

Publications for AKR7L Gene

  1. Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells. (PMID: 12879023) Praml C. … Schwab M. (Oncogene 2003) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Voxelwise genome-wide association study (vGWAS). (PMID: 20171287) Stein J.L. … Thompson P. (Neuroimage 2010) 3 49
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for AKR7L Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate AKR7L
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for AKR7L
    • Block miRNA regulation of AKR7L using miScript Target Protectors

    Sources for AKR7L Gene

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