Aliases for AKR7L Gene
External Ids for AKR7L Gene
Previous GeneCards Identifiers for AKR7L Gene
This gene is one of three aldo-keto reductase genes that are present in a cluster on the p arm of chromosome 1. The encoded proteins are involved in the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It has been speculated that this family member encodes a selenoprotein, which includes a selenocysteine (Sec) residue in lieu of a UGA translational termination codon. However, there is no evidence that such a protein is produced in vivo. The alternative interpretation is that this family member is a duplicated pseudogene, and it is therefore represented as such in this Gene record. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
GeneCards Summary for AKR7L Gene
AKR7L (Aldo-Keto Reductase Family 7-Like (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Aflatoxin activation and detoxification and Phase II conjugation. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is KCNAB1.
UniProtKB/Swiss-Prot for AKR7L Gene
Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).