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AKR7L Gene(Protein Coding)

Aldo-Keto Reductase Family 7 Like (Gene/Pseudogene)

GCID:
GC01M019265
GIFtS:
37
Genes Participants
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Aliases for AKR7L Gene

Aliases for AKR7L Gene

  • Aldo-Keto Reductase Family 7 Like (Gene/Pseudogene) 2 3 5
  • Aldo-Keto Reductase Family 7-Like 2 3
  • AFB1 Aldehyde Reductase 3 3 4
  • Aldoketoreductase 7-Like 3 4
  • AFB1-AR 3 3 4
  • AKR7A4 3 4
  • AFAR3 3 4
  • Aflatoxin B1 Aldehyde Reductase Member 4 3
  • Aldo-Keto Reductase Family 7 Pseudogene 3
  • EC 1.-.-.- 4
  • AFB1-AR3 3

External Ids for AKR7L Gene

Previous GeneCards Identifiers for AKR7L Gene

  • GC01M019466
  • GC01M019592
  • GC01M017838

Summaries for AKR7L Gene

Entrez Gene Summary for AKR7L Gene

  • This gene is one of three aldo-keto reductase genes that are present in a cluster on the p arm of chromosome 1. The encoded proteins are involved in the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It has been speculated that this family member encodes a selenoprotein, which includes a selenocysteine (Sec) residue in lieu of a UGA translational termination codon. However, there is no evidence that such a protein is produced in vivo. The alternative interpretation is that this family member is a segregating pseudogene, where some individuals have an allele that encodes a functional enzyme, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Feb 2017]

GeneCards Summary for AKR7L Gene

AKR7L (Aldo-Keto Reductase Family 7 Like (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Aflatoxin activation and detoxification and Metabolism. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is AKR7A3.

UniProtKB/Swiss-Prot for AKR7L Gene

  • Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR7L Gene

Genomics for AKR7L Gene

Products:

  1. Regulatory Element

Regulatory Elements for AKR7L Gene

Enhancers for AKR7L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G019310 1.4 Ensembl ENCODE 12.1 -39.3 -39297 6.7 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF143 OTUD3 AKR7L AKR7A2 ENSG00000272084 PQLC2 UBR4 GC01M019319 GC01M019320
GH01G019362 0.9 ENCODE dbSUPER 9.8 -89.7 -89660 2.4 BCOR ZNF680 ZMYM3 CBX5 HDAC2 RELB HNF4A KDM1A CAPZB PQLC2 AKR7A2 RNU6-1099P RNU4-28P AKR7L GC01P019361 LOC644083
GH01G019366 0.7 ENCODE dbSUPER 9.7 -93.3 -93329 1.7 GATA3 SCRT2 HNF4A PQLC2 AKR7A2 RNU6-1099P CAPZB AKR7L GC01P019361 LOC644083
GH01G019357 0.5 dbSUPER 9.8 -83.6 -83606 1.5 ZNF280D HDAC2 ZSCAN5C KDM1A NFE2 AKR7L CAPZB PQLC2 GC01P019355 GC01P019361
GH01G019358 0.5 dbSUPER 9.8 -83.6 -83564 1.4 ZNF280D HDAC2 ZSCAN5C KDM1A NFE2 AKR7L CAPZB PQLC2 GC01P019361 GC01P019355
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AKR7L on UCSC Golden Path with GeneCards custom track

Promoters for AKR7L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000002421 94 201 NR2F1 CEBPB MAX ELF1 HDAC8 YY1 KDM1A HNF4A

Transcription factor binding sites by QIAGEN in the AKR7L gene promoter:

Genomic Location for AKR7L Gene

Chromosome:
1
Start:
19,265,982 bp from pter
End:
19,274,194 bp from pter
Size:
8,213 bases
Orientation:
Minus strand

Genomic View for AKR7L Gene

Genes around AKR7L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKR7L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKR7L Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for AKR7L Gene

Proteins for AKR7L Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for AKR7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHP1-ARK74_HUMAN
    Recommended name:
    Aflatoxin B1 aldehyde reductase member 4
    Protein Accession:
    Q8NHP1
    Secondary Accessions:
    • Q5U614

    Protein attributes for AKR7L Gene

    Size:
    331 amino acids
    Molecular mass:
    36964 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AKR7L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKR7L Gene

Protein Expression for AKR7L Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for AKR7L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKR7L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AKR7L Gene

Domains & Families for AKR7L Gene

Protein Domains for AKR7L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AKR7L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHP1

UniProtKB/Swiss-Prot:

ARK74_HUMAN :
  • Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
Family:
  • Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
genes like me logo Genes that share domains with AKR7L: view

No data available for Gene Families for AKR7L Gene

Function for AKR7L Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for AKR7L Gene

UniProtKB/Swiss-Prot Function:
Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).

Enzyme Numbers (IUBMB) for AKR7L Gene

Gene Ontology (GO) - Molecular Function for AKR7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004033 aldo-keto reductase (NADP) activity TAS --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with AKR7L: view
genes like me logo Genes that share phenotypes with AKR7L: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKR7L Gene

Localization for AKR7L Gene

Gene Ontology (GO) - Cellular Components for AKR7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with AKR7L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for AKR7L Gene

Pathways & Interactions for AKR7L Gene

genes like me logo Genes that share pathways with AKR7L: view

Pathways by source for AKR7L Gene

Interacting Proteins for AKR7L Gene

Selected Interacting proteins: Q8NHP1-ARK74_HUMAN for AKR7L Gene via IID

Gene Ontology (GO) - Biological Process for AKR7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with AKR7L: view

No data available for SIGNOR curated interactions for AKR7L Gene

Drugs & Compounds for AKR7L Gene

Products:

  1. Drug

(2) Drugs for AKR7L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenium Approved, Vet_approved Pharma 180
Selenocysteine Experimental Pharma 0

(2) Additional Compounds for AKR7L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Aflatoxin B1
  • AFB1
  • AFBI
 1162-65-8
Aflatoxin B1 dialcohol
  • AFB1 dialcohol
genes like me logo Genes that share compounds with AKR7L: view

Transcripts for AKR7L Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for AKR7L Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(333) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AKR7L Gene

Aldo-keto reductase family 7-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKR7L Gene

No ASD Table

Relevant External Links for AKR7L Gene

GeneLoc Exon Structure for
AKR7L
ECgene alternative splicing isoforms for
AKR7L

Expression for AKR7L Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AKR7L Gene

mRNA expression in normal human tissues for AKR7L Gene
mRNA expression by GTEx for AKR7L Gene

mRNA differential expression in normal tissues according to GTEx for AKR7L Gene

This gene is overexpressed in Liver (x14.7), Small Intestine - Terminal Ileum (x6.4), Stomach (x5.4), and Pancreas (x5.1).

Protein differential expression in normal tissues from HIPED for AKR7L Gene

This gene is overexpressed in Liver (22.8), Kidney (14.5), Lung (8.6), and Gallbladder (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AKR7L Gene



Protein tissue co-expression partners for AKR7L Gene

NURSA nuclear receptor signaling pathways regulating expression of AKR7L Gene:

AKR7L

SOURCE GeneReport for Unigene cluster for AKR7L Gene:

Hs.662342

mRNA Expression by UniProt/SwissProt for AKR7L Gene:

Q8NHP1-ARK74_HUMAN
Tissue specificity: Mainly expressed in uterus.
genes like me logo Genes that share expression patterns with AKR7L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKR7L Gene

Orthologs for AKR7L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AKR7L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia AKR7A2 35
  • 37 (a)
 ManyToMany
dog
(Canis familiaris)
 Mammalia AKR7L 35
  • 27 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 26 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves -- 35
  • 22 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 20 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii akr7a3 35
  • 24 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes -- 35
  • 5 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 16 (a)
 OneToMany
Species where no ortholog for AKR7L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKR7L Gene

ENSEMBL:
Gene Tree for AKR7L (if available)
TreeFam:
Gene Tree for AKR7L (if available)

Paralogs for AKR7L Gene

Paralogs for AKR7L Gene

(2) SIMAP similar genes for AKR7L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AKR7L: view

Variants for AKR7L Gene

Sequence variations from dbSNP and Humsavar for AKR7L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000526528 -- 19,273,545(+) TTCCA(A/G)TGTTT intron-variant
rs1001293736 -- 19,273,736(+) GTGTG(C/G)ACAGG intron-variant
rs1001857246 -- 19,269,182(+) GCGAG(A/G)AAAGG intron-variant
rs1002788470 -- 19,266,584(+) GCTGA(G/T)ATTAC nc-transcript-variant
rs1002902932 -- 19,266,317(+) GTTTG(-/TTTC)TTTGT nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for AKR7L Gene

Variant ID Type Subtype PubMed ID
dgv25e199 CNV deletion 23128226
esv26443 CNV loss 19812545
esv3552788 CNV deletion 23714750
esv3585392 CNV loss 21293372
nsv945806 CNV duplication 23825009

Relevant External Links for AKR7L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKR7L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for AKR7L Gene

Disorders for AKR7L Gene

Relevant External Links for AKR7L

Genetic Association Database (GAD)
AKR7L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKR7L

No disorders were found for AKR7L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKR7L Gene

Publications for AKR7L Gene

  1. Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells. (PMID: 12879023) Praml C. … Schwab M. (Oncogene 2003) 2 3 4 64
  2. Voxelwise genome-wide association study (vGWAS). (PMID: 20171287) Stein J.L. … Thompson P. (Neuroimage 2010) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64

Products for AKR7L Gene

Sources for AKR7L Gene

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