AKR7A3 Gene
protein-coding GIFtS: 56
GCID: GC01M019610
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|
aldo-keto reductase family 7, member A3 (aflatoxin aldehyde...
| |
Aliases
for AKR7A3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Aldo-Keto Reductase Family 7, Member A3 (Aflatoxin Aldehyde Reductase)1 2 | | Aflatoxin B1 Aldehyde Reductase 22 | | AFAR22 3 | | Aflatoxin B1 Aldehyde Reductase Member 32 | | AFB1 Aldehyde Reductase 22 3 | | EC 1.-.-.-3 | | AFB1-AR 22 3 | | |
Export aliases for AKR7A3 gene to outside databasesPrevious GC identifers: GC01U990243 GC01M018634 GC01M018754 GC01M019078 GC01M019354 GC01M019481 GC01M017855 |
Summaries
for AKR7A3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for AKR7A3:
Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.(supplied by OMIM,Apr 2004)
UniProtKB/Swiss-Prot: ARK73_HUMAN, O95154Function: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. Maybe involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen
|
Genomic Views
for AKR7A3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AKR7A3 gene promoter:
RP58 NF-kappaB2 HTF Lmo2 IRF-1 NF-kappaB NF-kappaB1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for AKR7A3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKR7A3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13AKR7A3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M019610: view genomic region
(about GC identifiers)
Start:
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19,609,052 bp from pter |
End:
|
19,615,744 bp from pter |
Size:
|
6,693 bases |
Orientation:
|
minus strand |
|
Proteins
for AKR7A3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARK73_HUMAN, O95154 (See
protein sequence)Recommended Name: Aflatoxin B1 aldehyde reductase member 3 Size: 331 amino acids; 37206 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
1 PDB 3D structure from  and Proteopedia  for AKR7A3:2CLP (3D)
Secondary accessions: Q86SR4 Q8IVN6 Q8N5V6 Q8TAX1 Q9NUC3Explore the universe of human proteins at neXtProt for AKR7A3: NX_O95154
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95154
AKR7A3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036199.2
ENSEMBL proteins: ENSP00000355377
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
AKR7A3 for ontologies About GeneDecksing
AKR7A3 Antibody Products:
Assay Products for AKR7A3: |
Protein
Domains /
Families
for AKR7A3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AKR7A3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95154ProtoNet protein and cluster: O95154 1 Blocks protein family: IPB001395 Aldo/keto reductase
UniProtKB/Swiss-Prot: ARK73_HUMAN, O95154Similarity: Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily |
Function
for AKR7A3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ARK73_HUMAN, O95154Function: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. Maybe involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogenEnzyme Number (IUBMB): EC 1.-.-.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKR7A3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for AKR7A3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKR7A3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
AKR7A3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for AKR7A3:
|
Pathways & Interactions
for AKR7A3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Aflatoxin B1 metabolism | | | 2 | Biological oxidations | |
2  BioSystems Pathways for AKR7A3
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AKR7A3
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5 Interacting proteins for AKR7A3 (O951542, 3 ENSP000003553774) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006081 | cellular aldehyde metabolic process |
TAS | 10383892 | | GO:0046223 | aflatoxin catabolic process |
IEA | -- |
AKR7A3 for ontologies About GeneDecksing
|
Drugs & Compounds
for AKR7A3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AKR7A3
2 HMDB Compounds for AKR7A3 About this table
Search CenterWatch for drugs/clinical trials and news about AKR7A3 / ARK73
|
Transcripts
for AKR7A3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AKR7A3 gene: NM_012067.2 Unigene Cluster for AKR7A3: Aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) Hs.6980 [show with all ESTs]Unigene Representative Sequence: NM_0120671 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000361640(uc001bbv.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKR7A3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKR7A3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AKR7A3 (NM_012067) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AF040639.1 AJ271799.1 BC025709.1 BC031562.1 BC042420.1 3 DOTS entries: DT.75116548 DT.100028944 DT.316608 24/333 AceView cDNA sequences (see all 333): AA422120 BX281656 BM829901 BI835445 BM701761 BI759101 CR606608 AA353925 BX401279 BC011586 BC013996 BU542750 CR614593 NM_003689 BQ435451 BX362128 BK000395 NM_201252 BU629489 AL540565 BM722783 AI343752 BE886963 BM989496
GeneLoc Exon Structure
|
Expression
for AKR7A3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AKR7A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCAGCCTGG
About this image
See AKR7A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AKR7A3
SOURCE GeneReport for Unigene cluster: Hs.6980
UniProtKB/Swiss-Prot: ARK73_HUMAN, O95154Tissue specificity: Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium
SABiosciences Custom PCR Arrays for AKR7A3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKR7A3
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat AKR7A3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKR7A3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKR7A3 |
Orthologs
for AKR7A3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for AKR7A3 gene from 7/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
AKR7A26 |
Uncharacterized protein |
61(a) |
1 → many |
21(4682242-4686339) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
69(a) |
1 → many |
AAWZ02040488(128-4390) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.252322 |
Xenopus laevis transcribed sequence with weak similarity more |
75.38(n) |
|
BX844208.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:925026 |
zgc:92502 |
65(a) |
1 → many |
11(42944035-42951294) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G044206 |
NAD(P)-linked oxidoreductase-like protein |
16(a) |
possible ortholog |
1(1191608-1193884) |
rice
(Oryza sativa) |
Liliopsida |
---- |
oxidoreductase, aldo/keto reductase family protein...oxidoreductase, aldo/keto reductase family protein... |
19(a)17(a) |
possible orthologpossible ortholog |
11(25148345-25151223) 3(23084715-23088794) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
tas6 |
predicted oxidoreductase, NADP(H)-dependent aldo-k... |
19(a) |
possible ortholog |
Chromosome(2969619-2970659) |
ENSEMBL Gene Tree for AKR7A3 (if available)
TreeFam Gene Tree for AKR7A3 (if available) |
Paralogs
for AKR7A3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AKR7A3 gene
- KCNAB12 KCNAB32 AKR7A22 KCNAB22
2 SIMAP similar genes for AKR7A3 using alignment to 1 protein entry: ARK73_HUMAN:AKR7L AKR7A2
AKR7A3 for paralogs About GeneDecksing
|
Genomic Variants
for AKR7A3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AKR7A3 (19609052 - 19615744 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for AKR7A3
1 CNV: 68168
Human Gene Mutation Database (HGMD): AKR7A3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKR7A3 |
|
Disorders
/ Diseases
for AKR7A3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AKR7A3 for disorders About GeneDecksing
OMIM gene information: 608477
OMIM disorders: --
8  diseases for AKR7A3: About MalaCardsadult respiratory distress syndrome pancreas adenocarcinoma respiratory failure adenocarcinoma
esophagitis tuberculosis alcoholism mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: AKR7A3 (1 document)
Export disorders for AKR7A3 gene to outside databases
|
Publications
for AKR7A3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AKR7A3 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with AKR7A3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA cloning, expression and activity of a second human aflatoxin B1- metabolizing member of the aldo-keto reductase superfamily, AKR7A3. (PubMed id 10383892)1, 2, 3, 9 Knight L.P.... Sutter T.R. (1999)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells. (PubMed id 12879023)1, 2 Praml C.... Schwab M. (2003)
- Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3. (PubMed id 18416522)2, 9 Bodreddigari S.... Sutter T.R. (2008)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1 Liu C.Y....Christiani D.C. (2010)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for AKR7A3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AKR7A3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AKR7A3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AKR7A3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for AKR7A3 gene:
Search GeneIP for patents involving AKR7A3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AKR7A3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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