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Aliases for AKR7A3 Gene

Aliases for AKR7A3 Gene

  • Aldo-Keto Reductase Family 7, Member A3 (Aflatoxin Aldehyde Reductase) 2 3
  • AFAR2 3 4 6
  • AFB1 Aldehyde Reductase 2 3 4
  • AFB1-AR 2 3 4
  • Aflatoxin B1 Aldehyde Reductase Member 3 3
  • Aflatoxin B1 Aldehyde Reductase 2 3
  • EC 1.-.-.- 4

External Ids for AKR7A3 Gene

Summaries for AKR7A3 Gene

Entrez Gene Summary for AKR7A3 Gene

  • Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004]

GeneCards Summary for AKR7A3 Gene

AKR7A3 (Aldo-Keto Reductase Family 7, Member A3 (Aflatoxin Aldehyde Reductase)) is a Protein Coding gene. Diseases associated with AKR7A3 include adult respiratory distress syndrome. Among its related pathways are Biological oxidations and Chemical carcinogenesis. GO annotations related to this gene include electron carrier activity and aldo-keto reductase (NADP) activity. An important paralog of this gene is KCNAB2.

UniProtKB/Swiss-Prot for AKR7A3 Gene

  • Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR7A3 Gene

Genomics for AKR7A3 Gene

Genomic Location for AKR7A3 Gene

19,282,558 bp from pter
19,289,250 bp from pter
6,693 bases
Minus strand

Genomic View for AKR7A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKR7A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR7A3 Gene

Regulatory Elements for AKR7A3 Gene

Proteins for AKR7A3 Gene

  • Protein details for AKR7A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Aflatoxin B1 aldehyde reductase member 3
    Protein Accession:
    Secondary Accessions:
    • Q86SR4
    • Q8IVN6
    • Q8N5V6
    • Q8TAX1
    • Q9NUC3

    Protein attributes for AKR7A3 Gene

    331 amino acids
    Molecular mass:
    37206 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for AKR7A3 Gene

neXtProt entry for AKR7A3 Gene

Proteomics data for AKR7A3 Gene at MOPED

Post-translational modifications for AKR7A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKR7A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AKR7A3 Gene

Domains for AKR7A3 Gene

Gene Families for AKR7A3 Gene

  • AKR :Aldo-keto reductases

Protein Domains for AKR7A3 Gene


  • Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.:
    • O95154
genes like me logo Genes that share domains with AKR7A3: view

Function for AKR7A3 Gene

Molecular function for AKR7A3 Gene

UniProtKB/Swiss-Prot Function: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Enzyme Numbers (IUBMB) for AKR7A3 Gene

Gene Ontology (GO) - Molecular Function for AKR7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004033 aldo-keto reductase (NADP) activity TAS 10383892
GO:0009055 electron carrier activity TAS 10383892
genes like me logo Genes that share ontologies with AKR7A3: view

Phenotypes for AKR7A3 Gene

GenomeRNAi human phenotypes for AKR7A3:
genes like me logo Genes that share phenotypes with AKR7A3: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AKR7A3 Gene

Localization for AKR7A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR7A3 Gene


Subcellular locations from

Jensen Localization Image for AKR7A3 Gene COMPARTMENTS Subcellular localization image for AKR7A3 gene
Compartment Confidence
cytosol 4
mitochondrion 3
nucleus 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for AKR7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with AKR7A3: view

Pathways for AKR7A3 Gene

genes like me logo Genes that share pathways with AKR7A3: view

Pathways by source for AKR7A3 Gene

2 BioSystems pathways for AKR7A3 Gene
1 KEGG pathway for AKR7A3 Gene

Interacting Proteins for AKR7A3 Gene

Gene Ontology (GO) - Biological Process for AKR7A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006081 cellular aldehyde metabolic process TAS 10383892
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with AKR7A3: view

Compounds for AKR7A3 Gene

(2) HMDB Compounds for AKR7A3 Gene

Compound Synonyms Cas Number PubMed IDs
Aflatoxin B1
  • AFB1
Aflatoxin B1 dialcohol
  • AFB1 dialcohol
Not Available
genes like me logo Genes that share compounds with AKR7A3: view

Transcripts for AKR7A3 Gene

mRNA/cDNA for AKR7A3 Gene

Unigene Clusters for AKR7A3 Gene

Aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKR7A3 Gene

No ASD Table

Relevant External Links for AKR7A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AKR7A3 Gene

mRNA expression in normal human tissues for AKR7A3 Gene

mRNA differential expression in normal tissues according to GTEx for AKR7A3 Gene

This gene is overexpressed in Pancreas (19.6), Stomach (10.8), and Liver (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKR7A3 Gene

SOURCE GeneReport for Unigene cluster for AKR7A3 Gene Hs.6980

mRNA Expression by UniProt/SwissProt for AKR7A3 Gene

Tissue specificity: Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium.
genes like me logo Genes that share expressions with AKR7A3: view

Orthologs for AKR7A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AKR7A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AKR7A3 36
  • 95.76 (n)
  • 93.25 (a)
AKR7A3 37
  • 98 (a)
(Bos Taurus)
Mammalia AKR7A2 37
  • 87 (a)
(Mus musculus)
Mammalia Akr7a5 37
  • 76 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 69 (a)
(Rattus norvegicus)
Mammalia Akr7a3 36
  • 82.16 (n)
  • 80.73 (a)
(Gallus gallus)
Aves -- 37
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 69 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25232 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2085 36
(Danio rerio)
Actinopterygii akr7a3 37
  • 65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 20 (a)
AAD10 39
bread mold
(Neurospora crassa)
Ascomycetes NCU07240 36
  • 53.95 (n)
  • 44.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 49 (a)
Species with no ortholog for AKR7A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKR7A3 Gene

Gene Tree for AKR7A3 (if available)
Gene Tree for AKR7A3 (if available)

Paralogs for AKR7A3 Gene

Paralogs for AKR7A3 Gene

Selected SIMAP similar genes for AKR7A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AKR7A3: view

Variants for AKR7A3 Gene

Sequence variations from dbSNP and Humsavar for AKR7A3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1061670 -- 19,282,719(-) CGTTT(C/T)TCAGG utr-variant-3-prime
rs1061671 -- 19,282,701(-) AGGCT(C/T)TTCTG utr-variant-3-prime
rs1061672 -- 19,282,642(-) AAATT(C/T)TTAGG utr-variant-3-prime
rs1061673 -- 19,282,596(-) TCACC(A/C)CCAAA utr-variant-3-prime
rs1065658 -- 19,284,733(-) CAGCC(C/T)GTGGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for AKR7A3 Gene

Variant ID Type Subtype PubMed ID
nsv871933 CNV Loss 21882294
esv2744819 CNV Deletion 23290073
dgv25e199 CNV Deletion 23128226
esv26443 CNV Loss 19812545

Relevant External Links for AKR7A3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for AKR7A3 Gene

(1) University of Copenhagen DISEASES for AKR7A3 Gene

Relevant External Links for AKR7A3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with AKR7A3: view

No data available for UniProtKB/Swiss-Prot for AKR7A3 Gene

Publications for AKR7A3 Gene

  1. cDNA cloning, expression and activity of a second human aflatoxin B1- metabolizing member of the aldo-keto reductase superfamily, AKR7A3. (PMID: 10383892) Knight L.P. … Sutter T.R. (Carcinogenesis 1999) 2 3 4 23
  2. Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3. (PMID: 18416522) Bodreddigari S. … Sutter T.R. (Chem. Res. Toxicol. 2008) 4 23
  3. Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells. (PMID: 12879023) Praml C. … Schwab M. (Oncogene 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 49

Products for AKR7A3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate AKR7A3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for AKR7A3
    • Block miRNA regulation of AKR7A3 using miScript Target Protectors

    Sources for AKR7A3 Gene

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