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AKR7A3 Gene

protein-coding   GIFtS: 62
GCID: GC01M019610

Aldo-Keto Reductase Family 7, Member A3 (Aflatoxin Aldehyde...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aldo-Keto Reductase Family 7, Member A3 (Aflatoxin Aldehyde
Reductase)1 2
     Aflatoxin B1 Aldehyde Reductase 22
AFAR22 3 5     Aflatoxin B1 Aldehyde Reductase Member 32
AFB1 Aldehyde Reductase 22 3     EC 1.-.-.-3
AFB1-AR 22 3     

External Ids:    HGNC: 3901   Entrez Gene: 229772   Ensembl: ENSG000001624827   OMIM: 6084775   UniProtKB: O951543   

Export aliases for AKR7A3 gene to outside databases

Previous GC identifers: GC01U990243 GC01M018634 GC01M018754 GC01M019078 GC01M019354 GC01M019481 GC01M017855


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AKR7A3 Gene:
Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.(supplied by
OMIM, Apr 2004)

GeneCards Summary for AKR7A3 Gene:
AKR7A3 (aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)) is a protein-coding gene. Diseases associated with AKR7A3 include pancreas adenocarcinoma, and adult respiratory distress syndrome. GO annotations related to this gene include electron carrier activity and aldo-keto reductase (NADP) activity. An important paralog of this gene is KCNAB1.

UniProtKB/Swiss-Prot: ARK73_HUMAN, O95154
Function: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol.
May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent
hepatocarcinogen




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the AKR7A3 gene promoter:
         RP58   NF-kappaB2   HTF   Lmo2   IRF-1   NF-kappaB   NF-kappaB1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAKR7A3 promoter sequence
   Search Chromatin IP Primers for AKR7A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKR7A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

AKR7A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKR7A3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M019610:  view genomic region     (about GC identifiers)

Start:
19,609,052 bp from pter      End:
19,615,744 bp from pter
Size:
6,693 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ARK73_HUMAN, O95154 (See protein sequence)
Recommended Name: Aflatoxin B1 aldehyde reductase member 3  
Size: 331 amino acids; 37206 Da
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for AKR7A3:
2CLP (3D)    
Secondary accessions: Q86SR4 Q8IVN6 Q8N5V6 Q8TAX1 Q9NUC3

Explore the universe of human proteins at neXtProt for AKR7A3: NX_O95154

Explore proteomics data for AKR7A3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AKR7A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036199.2  
    ENSEMBL proteins: 
     ENSP00000355377  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AKR: Aldo-keto reductases

    2 InterPro protein domains:
     IPR001395 Aldo/ket_red
     IPR023210 NADP_OxRdtase_dom

    Graphical View of Domain Structure for InterPro Entry O95154

    ProtoNet protein and cluster: O95154

    1 Blocks protein domain: IPB001395 Aldo/keto reductase

    UniProtKB/Swiss-Prot: ARK73_HUMAN, O95154
    Similarity: Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily


    AKR7A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARK73_HUMAN, O95154
    Function: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol.
    May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent
    hepatocarcinogen

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004032alditol:NADP+ 1-oxidoreductase activity IEA--
    GO:0004033aldo-keto reductase (NADP) activity TAS10383892
    GO:0009055electron carrier activity TAS10383892
         
    AKR7A3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AKR7A3:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AKR7A3
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARK73_HUMAN, O95154: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion3
    nucleus2
    chloroplast1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS10383892
    GO:0070062extracellular vesicular exosome IDA19056867

    AKR7A3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AKR7A3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Chemical carcinogenesis
    Metabolism of xenobiotics by cytochrome P4500.71
    Aflatoxin B1 metabolism0.00
    2Biological oxidations
    metapathway biotransformation0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for AKR7A3
        Aflatoxin B1 metabolism
    metapathway biotransformation



    1 Kegg Pathway  (Kegg details for AKR7A3):
        Metabolism of xenobiotics by cytochrome P450


    AKR7A3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AKR7A3
    Interactions:

        Search GeneGlobe Interaction Network for AKR7A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for AKR7A3 (O951542, 3 ENSP000003553774) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKR7A2O434882, 3, ENSP000002358354MINT-67373 I2D: score=5 STRING: ENSP00000235835
    NXT2Q9NPJ83I2D: score=1 
    TMEM50AO958073I2D: score=1 
    AKR7A3O951542MINT-67398
    TERF2IPENSP000003000864STRING: ENSP00000300086
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006081cellular aldehyde metabolic process TAS10383892
    GO:0046222aflatoxin metabolic process ----
    GO:0046223aflatoxin catabolic process IEA--

    AKR7A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for AKR7A3 (ARK73)

    2 HMDB Compounds for AKR7A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Aflatoxin B1AFB1 (see all 2)1162-65-8--
    Aflatoxin B1 dialcoholAFB1 dialcohol ----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AKR7A3 gene: 
    NM_012067.2  

    Unigene Cluster for AKR7A3:

    Aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
    Hs.6980  [show with all ESTs]
    Unigene Representative Sequence: NM_012067
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000361640(uc001bbv.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat AKR7A3
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    Additional mRNA sequence: 

    AF040639.1 AJ271799.1 BC025709.1 BC031562.1 BC042420.1 

    3 DOTS entries:

    DT.75116548  DT.100028944  DT.316608 

    Selected AceView cDNA sequences (see all 333):

    BU542750 BQ435451 BX401279 BK000395 AI343752 AA422120 BX281656 BM701761 
    BM829901 BI835445 BI759101 BU944847 AF026947 AV653525 BC012171 BM989496 
    CR618917 BM666611 CR610843 CD673705 BU732960 CR606766 BU737899 BM722783 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AKR7A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAGCCTGG
    AKR7A3 Expression
    About this image

    AKR7A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKR7A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6980

    UniProtKB/Swiss-Prot: ARK73_HUMAN, O95154
    Tissue specificity: Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AKR7A3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    62(a)
    1 → many
    21(4669158-4673255)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    69(a)
    1 → many
    AAWZ02040488(128-4390)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.252322 Xenopus laevis transcribed sequence with weak similarity more 75.38(n)    BX844208.1 
    zebrafish
    (Danio rerio)
    Actinopterygii akr7a36
    aldo-keto reductase family 7, member A3 (aflatoxin...
    65(a)
    1 → many
    11(42944035-42951294) ENSDARG00000016649
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AAD10(YJR155W)4 Putative aryl-alcohol dehydrogenase; similar to P. more   --   10(727405-728271) 853620  NP_012689.1 
            Species with no ortholog for AKR7A3

    ENSEMBL Gene Tree for AKR7A3 (if available)
    TreeFam Gene Tree for AKR7A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AKR7A3 gene
    KCNAB12  KCNAB32  AKR7L2  AKR7A22  KCNAB22  
    2 SIMAP similar genes for AKR7A3 using alignment to 1 protein entry:     ARK73_HUMAN:
    AKR7L    AKR7A2

    AKR7A3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AKR7A3 (see all 313)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1851555941,2
    --19608616(+) TTTGCC/GGGGGG 1 -- int10--------
    rs776247781,2
    C,F--19608646(+) ATCATC/TAGGGT 1 -- int11Minor allele frequency- T:0.06NA 120
    rs787588321,2
    --19608659(+) TTTGTA/CCCCTC 1 -- int10--------
    rs1385642661,2
    --19608672(+) AATCTC/GATGTT 1 -- int10--------
    rs1439563601,2
    --19608702(+) TAGAGG/TTGAGC 1 -- int10--------
    rs774257551,2
    C,F--19608724(+) GGTTAG/CGGTAT 1 -- int12Minor allele frequency- C:0.05NA EA 240
    rs1147896221,2
    F--19608744(+) TCCCAC/TATGAA 1 -- int11Minor allele frequency- T:0.02NA 120
    rs17380261,2
    C,F,A,H--19608769(-) ttactG/Atacag 1 -- int132Minor allele frequency- A:0.07NS EA NA WA CSA 2907
    rs1909606451,2
    --19608778(+) AATGAA/GTGAGT 1 -- int10--------
    rs1386825181,2
    C--19608792(+) AGCTC-/TATGAGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for AKR7A3 (19609052 - 19615744 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for AKR7A3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744819CNV Deletion23290073
    dgv25e199CNV Deletion23128226
    nsv871933CNV Loss21882294
    esv26443CNV Loss19812545

    Human Gene Mutation Database (HGMD): AKR7A3
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608477    OMIM disorders: --

    6 diseases for AKR7A3:    About MalaCards
    pancreas adenocarcinoma    adult respiratory distress syndrome    respiratory failure    esophagitis
    adenocarcinoma    tuberculosis

    1 disease from the University of Copenhagen DISEASES database for AKR7A3:
    Adult respiratory distress syndrome

    AKR7A3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AKR7A3
    Human Genome Epidemiology (HuGE) Navigator: AKR7A3 (1 document)

    Export disorders for AKR7A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AKR7A3 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with AKR7A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, expression and activity of a second human aflatoxin B1- metabolizing member of the aldo-keto reductase superfamily, AKR7A3. (PubMed id 10383892)1, 2, 3, 9 Knight L.P.... Sutter T.R. (Carcinogenesis 1999)
    2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells. (PubMed id 12879023)1, 2 Praml C.... Schwab M. (Oncogene 2003)
    6. Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3. (PubMed id 18416522)2, 9 Bodreddigari S.... Sutter T.R. (Chem. Res. Toxicol. 2008)
    7. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    8. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
    9. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22977 HGNC: 390 AceView: AKR7A2andAKR7A3andAFAR3 Ensembl:ENSG00000162482 euGenes: HUgn22977
    ECgene: AKR7A3 Kegg: 22977 H-InvDB: AKR7A3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AKR7A3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AKR7A3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AKR7A3 gene:
    Search GeneIP for patents involving AKR7A3

    GeneCards and IP:
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