Aliases for AKR7A2 Gene
Aliases for AKR7A2 Gene
External Ids for AKR7A2 Gene
- HGNC: 389
- Entrez Gene: 8574
- Ensembl: ENSG00000053371
- OMIM: 603418
- UniProtKB: O43488
Previous GeneCards Identifiers for AKR7A2 Gene
- GC01M019169
- GC01M018618
- GC01M018755
- GC01M019101
- GC01M019102
- GC01M019375
- GC01M019503
- GC01M019630
- GC01M017876
Summaries for AKR7A2 Gene
-
The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
GeneCards Summary for AKR7A2 Gene
AKR7A2 (Aldo-Keto Reductase Family 7 Member A2) is a Protein Coding gene. Diseases associated with AKR7A2 include Pancreatic Cystadenoma and Gamma-Amino Butyric Acid Metabolism Disorder. Among its related pathways are Cytochrome P450 - arranged by substrate type and Naphthalene metabolism. GO annotations related to this gene include electron carrier activity and phenanthrene-9,10-epoxide hydrolase activity. An important paralog of this gene is AKR7L.
UniProtKB/Swiss-Prot for AKR7A2 Gene
-
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR7A2 Gene
Genomics for AKR7A2 Gene
Regulatory Elements for AKR7A2 Gene
Enhancers for AKR7A2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around AKR7A2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for AKR7A2 Gene
- Chromosome:
- 1
- Start:
- 19,302,708 bp from pter
- End:
- 19,312,146 bp from pter
- Size:
- 9,439 bases
- Orientation:
- Minus strand
Genomic View for AKR7A2 Gene
Genes around AKR7A2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.13 by Ensembl
- 1p36.13 by Entrez Gene
- 1p36.13 by HGNC
AKR7A2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AKR7A2 Gene
Proteins for AKR7A2 Gene
-
Protein details for AKR7A2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43488-ARK72_HUMAN
- Recommended name:
- Aflatoxin B1 aldehyde reductase member 2
- Protein Accession:
- O43488
- O75749
- Q5TG63
Protein attributes for AKR7A2 Gene
- Size:
- 359 amino acids
- Molecular mass:
- 39589 Da
- Quaternary structure:
-
- Homodimer.
- SequenceCaution:
-
- Sequence=AAC52104.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH04111.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH10852.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH11586.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12171.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH13996.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP36011.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA76347.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB72321.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for AKR7A2 Gene
Post-translational modifications for AKR7A2 Gene
Other Protein References for AKR7A2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for AKR7A2
- Novus Biologicals Antibodies for AKR7A2
- Invitrogen Antibodies for AKR7A2
- antibodies-online Antibodies for AKR7A2: See all 61
- GeneTex AKR7A2 antibody for AKR7A2
-
Santa Cruz Biotechnology (SCBT) Antibodies for AKR7A2
Protein Products
-
OriGene Purified Proteins for AKR7A2
- Search Origene for MassSpec and Protein Over-expression Lysates for AKR7A2
- Origene Custom Protein Services for AKR7A2
- ProSpec Recombinant Proteins for AKR7A2
- antibodies-online Proteins for AKR7A2: See all 14
- Search antibodies-online for peptides
- Search GeneTex for Proteins for AKR7A2
Assay Products
- antibodies-online Kits for AKR7A2: See all 7
No data available for DME Specific Peptides for AKR7A2 Gene
Domains & Families for AKR7A2 Gene
Gene Families for AKR7A2 Gene
Protein Domains for AKR7A2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for AKR7A2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O43488UniProtKB/Swiss-Prot:
ARK72_HUMAN :- Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
- Family:
-
- Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
Function for AKR7A2 Gene
Molecular function for AKR7A2 Gene
- GENATLAS Biochemistry:
- aldo-ketoreductase 7,homolog of rattus norvegicus gene,expressed in brain,heart,lung,prostate,skeletal,muscle,spleen,testis,stomach,pancreas,kidney,liver,also expressed in renal carcinoma cells,involved in endogenous detoxication pathway,catalyzing the recuction of 2-carboxybenzaldehyde (2-CBA) and related molecules
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=20 uM for succinic semialdehyde {ECO:0000269 PubMed:10510318}; KM=17 uM for 2-carboxybenzaldehyde {ECO:0000269 PubMed:10510318}; KM=8 uM for 9,10-phenanthrenequinone {ECO:0000269 PubMed:10510318}; KM=102 uM for 1,2-naphthoquinone {ECO:0000269 PubMed:10510318};
- UniProtKB/Swiss-Prot CatalyticActivity:
- 4-hydroxybutanoate + NADP(+) = succinate semialdehyde + NADPH.
- UniProtKB/Swiss-Prot Function:
- Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Enzyme Numbers (IUBMB) for AKR7A2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004032 | alditol:NADP+ 1-oxidoreductase activity | TAS | 9576847 |
| GO:0004033 | aldo-keto reductase (NADP) activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0009055 | electron carrier activity | TAS | 9576847 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
Phenotypes for AKR7A2 Gene
- GenomeRNAi human phenotypes for AKR7A2:
Animal Model Products
-
Taconic Biosciences Mouse Models for AKR7A2
- Cyagen custom Knockout/knockin (KOKI) mouse models for AKR7A2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for AKR7A2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AKR7A2 gene
- Search ViGene Biosciences for AKR7A2
CRISPR Products
-
OriGene CRISPR knockouts for AKR7A2
-
Santa Cruz Biotechnology (SCBT) CRISPR for AKR7A2
- GenScript: Design CRISPR guide RNA sequences for AKR7A2
miRNA for AKR7A2 Gene
- miRTarBase miRNAs that target AKR7A2
-
- hsa-mir-155-5p (MIRT020602)
- hsa-mir-34a-5p (MIRT025267)
- hsa-mir-7-5p (MIRT025659)
- hsa-mir-20a-5p (MIRT050598)
- hsa-mir-3611 (MIRT447941)
- hsa-mir-758-3p (MIRT447942)
- hsa-mir-6808-3p (MIRT447943)
- hsa-mir-4439 (MIRT447944)
- hsa-mir-6820-3p (MIRT447945)
- hsa-mir-3136-5p (MIRT447946)
- hsa-mir-3164 (MIRT447947)
- hsa-mir-3118 (MIRT447948)
- hsa-mir-134-5p (MIRT447949)
- hsa-mir-6857-3p (MIRT447950)
- hsa-mir-6855-3p (MIRT447951)
- hsa-mir-4513 (MIRT447952)
- hsa-mir-4511 (MIRT447953)
- hsa-mir-3185 (MIRT447954)
- hsa-mir-3133 (MIRT447955)
- hsa-mir-5585-3p (MIRT462110)
- hsa-mir-3162-5p (MIRT462111)
- hsa-mir-4708-3p (MIRT462112)
- hsa-mir-1224-3p (MIRT462113)
- hsa-mir-3681-3p (MIRT462114)
- hsa-mir-216a-3p (MIRT462115)
- hsa-mir-128-3p (MIRT462116)
- hsa-mir-135a-3p (MIRT462117)
- hsa-mir-4756-5p (MIRT462118)
- hsa-mir-4739 (MIRT462119)
- hsa-mir-6760-5p (MIRT462120)
- hsa-mir-1321 (MIRT462121)
- hsa-mir-4796-3p (MIRT462122)
- hsa-mir-93-5p (MIRT462123)
- hsa-mir-526b-3p (MIRT462124)
- hsa-mir-519d-3p (MIRT462125)
- hsa-mir-20b-5p (MIRT462126)
- hsa-mir-17-5p (MIRT462127)
- hsa-mir-106b-5p (MIRT462128)
- hsa-mir-106a-5p (MIRT462129)
- hsa-mir-548ah-5p (MIRT462130)
- hsa-mir-3609 (MIRT462131)
- hsa-mir-6510-3p (MIRT542448)
- hsa-mir-6864-3p (MIRT542449)
- hsa-mir-3672 (MIRT542450)
- hsa-mir-6888-3p (MIRT542451)
- hsa-mir-196a-3p (MIRT542452)
- hsa-mir-661 (MIRT542453)
- hsa-mir-873-3p (MIRT542454)
- hsa-mir-4522 (MIRT542455)
- hsa-mir-3120-5p (MIRT542456)
- hsa-mir-6860 (MIRT542457)
- hsa-mir-612 (MIRT542458)
- hsa-mir-5189-5p (MIRT542459)
- hsa-mir-3187-5p (MIRT542460)
- hsa-mir-1285-3p (MIRT542461)
- hsa-mir-939-3p (MIRT542462)
- hsa-mir-6849-3p (MIRT542463)
- hsa-mir-3065-5p (MIRT542464)
- hsa-mir-520h (MIRT542465)
- hsa-mir-520g-3p (MIRT542466)
- hsa-mir-3664-5p (MIRT542467)
- hsa-mir-3680-3p (MIRT573300)
- hsa-mir-557 (MIRT573301)
- hsa-mir-507 (MIRT573302)
- hsa-mir-450b-5p (MIRT573303)
- hsa-mir-527 (MIRT573304)
- hsa-mir-518a-5p (MIRT573305)
- hsa-mir-548aw (MIRT573306)
- hsa-mir-1290 (MIRT573307)
- hsa-mir-876-5p (MIRT573308)
- hsa-mir-3167 (MIRT573309)
- hsa-mir-1246 (MIRT573310)
- hsa-mir-4694-3p (MIRT573311)
- hsa-mir-6744-3p (MIRT632129)
- hsa-mir-6878-3p (MIRT632130)
- hsa-mir-4757-5p (MIRT632131)
- hsa-mir-4772-3p (MIRT632132)
- hsa-mir-6787-3p (MIRT632133)
- hsa-mir-212-5p (MIRT632134)
- hsa-mir-6736-3p (MIRT632135)
- hsa-mir-6890-3p (MIRT632136)
- hsa-mir-6813-3p (MIRT632137)
- hsa-mir-6829-3p (MIRT641673)
- hsa-mir-6791-3p (MIRT641674)
- hsa-mir-1304-3p (MIRT641675)
- hsa-mir-216a-5p (MIRT641676)
- hsa-mir-6869-5p (MIRT711912)
- hsa-mir-1200 (MIRT711913)
- hsa-mir-7151-3p (MIRT711914)
- hsa-mir-5095 (MIRT711915)
- hsa-mir-365b-5p (MIRT711916)
- hsa-mir-365a-5p (MIRT711917)
- hsa-mir-8052 (MIRT711918)
- hsa-mir-3199 (MIRT711919)
- hsa-mir-6804-3p (MIRT711920)
- hsa-mir-3653-5p (MIRT711921)
- hsa-mir-544b (MIRT711922)
- hsa-mir-4324 (MIRT711923)
- hsa-mir-660-3p (MIRT711924)
- hsa-mir-6715b-5p (MIRT711925)
- hsa-mir-4269 (MIRT711926)
- hsa-mir-4438 (MIRT711927)
miRNA Products
- Search ViGene Biosciences for AKR7A2
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for AKR7A2
- Browse OriGene Inhibitory RNA Products For AKR7A2
-
ViGene Biosciences ready-to-package AAV shRNAs for AKR7A2 gene
Clone Products
-
OriGene ORF clones in human for AKR7A2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for AKR7A2
- VectorBuilder custom plasmid, inducible vectors for AKR7A2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AKR7A2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for AKR7A2
-
ViGene Biosciences adenoviral particle packaged cDNA for AKR7A2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for AKR7A2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AKR7A2 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKR7A2 Gene
Localization for AKR7A2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for AKR7A2 Gene
- Golgi apparatus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| golgi apparatus | 3 |
| mitochondrion | 2 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005829 | cytosol | IDA,TAS | -- |
| GO:0070062 | extracellular exosome | IDA | 19056867 |
Pathways & Interactions for AKR7A2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Cytochrome P450 - arranged by substrate type | ||
| 3 | Aflatoxin activation and detoxification | ||
| 4 | Metabolism |
.37
|
|
| 5 | Naphthalene metabolism | ||
Pathways by source for AKR7A2 Gene
2 BioSystems pathways for AKR7A2 Gene
3 Reactome pathways for AKR7A2 Gene
1 KEGG pathway for AKR7A2 Gene
1 GeneGo (Thomson Reuters) pathway for AKR7A2 Gene
Interacting Proteins for AKR7A2 Gene
Selected Interacting proteins:
ENSP00000235835
O43488-ARK72_HUMAN
for AKR7A2 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | TAS | 9576847 |
| GO:0006081 | cellular aldehyde metabolic process | TAS | 9576847 |
| GO:0006805 | xenobiotic metabolic process | TAS | -- |
| GO:0044597 | daunorubicin metabolic process | IMP | 20837989 |
| GO:0044598 | doxorubicin metabolic process | IMP | 20837989 |
No data available for SIGNOR curated interactions for AKR7A2 Gene
Drugs & Compounds for AKR7A2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Gamma Hydroxybutyric Acid | Approved, Illicit | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Aflatoxin B1 |
|
1162-65-8 | ||||
| Aflatoxin B1 dialcohol |
|
|
||||
| NADP |
|
53-59-8 |
|
|||
| nadph |
|
53-57-6 |
|
|||
| Succinic acid semialdehyde |
|
692-29-5 |
|
Transcripts for AKR7A2 Gene
mRNA/cDNA for AKR7A2 Gene
- (2) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (333) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for AKR7A2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for AKR7A2
-
Santa Cruz Biotechnology (SCBT) CRISPR for AKR7A2
- GenScript: Design CRISPR guide RNA sequences for AKR7A2
miRNA Products
- Search ViGene Biosciences for AKR7A2
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for AKR7A2
- Browse OriGene Inhibitory RNA Products For AKR7A2
-
ViGene Biosciences ready-to-package AAV shRNAs for AKR7A2 gene
Clone Products
-
OriGene ORF clones in human for AKR7A2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for AKR7A2
- VectorBuilder custom plasmid, inducible vectors for AKR7A2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AKR7A2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||
| SP2: | - |
Expression for AKR7A2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Ovary (Reproductive System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AKR7A2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of AKR7A2 Gene:
AKR7A2SOURCE GeneReport for Unigene cluster for AKR7A2 Gene:
Hs.571886mRNA Expression by UniProt/SwissProt for AKR7A2 Gene:
O43488-ARK72_HUMAN
Tissue specificity:
Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowmans capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed.
Evidence on tissue expression from TISSUES for AKR7A2 Gene
- Nervous system(4.7)
- Liver(4.5)
- Skin(4.3)
- Pancreas(4.2)
- Gall bladder(2.2)
- Kidney(2.2)
- Stomach(2.2)
Primer Products
-
OriGene qPCR primer pairs for AKR7A2
-
OriGene qPCR primer pairs and template standards for AKR7A2
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKR7A2 Gene
Orthologs for AKR7A2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AKR7A2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | AKR7A2 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Akr7a2 34 |
|
||
| cow (Bos Taurus) |
Mammalia | AKR7A2 34 |
|
||
| -- 35 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Akr7a5 34 16 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | AKR7A2 34 |
|
||
| -- 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | akr7a2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | akr7a3 34 35 |
|
||
| wufb48h07 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11179 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for AKR7A2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for AKR7A2 Gene
(2) SIMAP similar genes for AKR7A2 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for AKR7A2 Gene
Variants for AKR7A2 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000083657 | -- | 19,310,817(+) | AGGGG(G/T)GGGGA | intron-variant, upstream-variant-2KB | |
| rs1000348737 | -- | 19,304,993(+) | TCTTT(G/T)TTTTT | intron-variant | |
| rs1000444243 | -- | 19,310,455(+) | CACTT(C/T)GGGAG | intron-variant, upstream-variant-2KB | |
| rs1000538528 | -- | 19,311,456(+) | GCCCA(C/G)GGTGT | intron-variant, upstream-variant-2KB | |
| rs1000665176 | -- | 19,306,125(+) | GGCCT(C/G/T)GAAGT | nc-transcript-variant, reference, missense |
Residual Variation Intolerance Score:
90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.01;
80.11% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for AKR7A2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKR7A2 Gene
Disorders for AKR7A2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pancreatic cystadenoma |
|
|
| gamma-amino butyric acid metabolism disorder |
|
|
| intermediate charcot-marie-tooth neuropathy |
|
|
| succinic semialdehyde dehydrogenase deficiency |
|
|
| contagious pustular dermatitis |
|
|
Search AKR7A2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for AKR7A2
No data available for UniProtKB/Swiss-Prot and Genatlas for AKR7A2 Gene
Publications for AKR7A2 Gene
- Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase. (PMID: 9576847) Ireland L.S. … Hayes J.D. (Biochem. J. 1998) 2 3 4 22 64
- Genetic variation of aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells. (PMID: 18752886) Praml C. … Henrich K.-O. (Cancer Lett. 2008) 3 4 22 64
- Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins. (PMID: 12071861) Kelly V.P. … Hayes J.D. (Biochem. J. 2002) 3 4 22 64
- Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35- 1p36.1 in a region frequently altered in human tumor cells. (PMID: 9823300) Praml C. … Schwab M. (Cancer Res. 1998) 3 4 22 64
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
Products for AKR7A2 Gene
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