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AKR7A2 Gene

protein-coding   GIFtS: 54

GC01M019630
aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for AKR7A2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)1 2     AFB1-AR 12 3
AFAR1 2 3     SSA reductase2 3
Succinic semialdehyde reductase2 3     aflatoxin B1 aldehyde reductase member 22
Aldoketoreductase 72 3     aflatoxin beta1 aldehyde reductase2
AFB1 aldehyde reductase 12 3     AFB1-AR12
AKR72 3     EC 1.1.1.n113
AFAR12 3     

External Ids:    HGNC: 3891   Entrez Gene: 85742   Ensembl: ENSG000000533717   UniProtKB: O434883   

Search outside databases for aliases for AKR7A2 gene

Previous GC identifers: GC01M019169 GC01M018618 GC01M018755 GC01M019101 GC01M019102 GC01M019375 GC01M019503

Summaries
for AKR7A2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  User Feedback		 Entrez Gene summary for AKR7A2:
Aldo-keto reductases, such as AKR7A2, are involved in the detoxification of aldehydes and ketones.(supplied by OMIM)

UniProtKB/Swiss-Prot: ARK72_HUMAN, O43488
Function: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an
important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has
NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde
(in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde
protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver
against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen

Gene Wiki entry for AKR7A2

Genomic Views
for AKR7A2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the AKR7A2 gene upstream (promoter) region "":
E47   p53   LUN-1   NF-kappaB   NF-kappaB1   ZID   GR-alpha   AP-4   GATA-3   LCR-F1   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for AKR7A2:  ""
MePH00399-2A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

AKR7A2 Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M019630:  view genomic region     (about GC identifiers)

Start:
 19,630,459 bp from pter
End:
 19,638,640 bp from pter
Size:
 8,182 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  

Proteins
for AKR7A2 gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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  User Feedback		 UniProtKB/Swiss-Prot: ARK72_HUMAN, O43488 (See protein sequence)
Recommended Name: Aflatoxin B1 aldehyde reductase member 2  
Size: 359 amino acids; 39589 Da
Subunit: Homodimer
Subcellular location: Golgi apparatus (By similarity). Cytoplasm
Caution: It is uncertain whether Met-1 or Met-30 is the initiator
Sequence caution: Sequence=AAC52104.1; Type=Erroneous initiation; Sequence=AAH04111.3; Type=Erroneous initiation;
Sequence=AAH10852.1; Type=Erroneous initiation; Sequence=AAH11586.1; Type=Erroneous initiation; Sequence=AAH12171.1;
Type=Erroneous initiation; Sequence=AAH13996.1; Type=Erroneous initiation; Sequence=AAP36011.1; Type=Erroneous
initiation; Sequence=CAA76347.1; Type=Erroneous initiation; Sequence=CAB72321.1; Type=Erroneous initiation;
PDB structures from "" and Proteopedia "" :
2BP1 (3D) ""    
Secondary accessions: O75749 Q5TG63

REFSEQ proteins: NP_003680.2  

ENSEMBL proteins: 
ENSP00000394328 ENSP00000235835 ENSP00000419936 ENSP00000417891 ENSP00000339084 


Human Recombinant Proteins 
""Browse Purified and Recombinant Proteins at Millipore
""Browse Human Recombinant Proteins at Sigma-Aldrich
"" Browse R&D Systems for human recombinant proteins
""Browse recombinant and purified proteins available from Enzo Life Sciences
""HuPro® and/or Recombinant Proteins from Abnova for AKR7A2 ""
""Browse Origene full length recombinant human proteins expressed in human HEK293 cells
""Novus Biologicals Proteins for AKR7A2  ""
Novus Biologicals Lysate for AKR7A2
""Browse Sino Biological Recombinant Proteins  ""

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IEA--
GO:0005794 Golgi apparatus IEA--
About this table

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Antibodies for AKR7A2: 
""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
""Sigma-Aldrich Antibodies for AKR7A2
"" Browse R&D Systems for Antibodies
""Monoclonal and Polyclonal Antibodies from Abnova (AKR7A2)
""Browse Origene Antibodies ""
""Novus Biologicals Antibodies for AKR7A2
""Browse antibodies at Epitomics

Assays for AKR7A2: 
""Browse Kits and Assays available from Millipore
""Browse ELISAs at Sigma-Aldrich
"" Browse R&D Systems for biochemical assays
""Browse Enzo Life Sciences for kits & assays

Protein Domains/
Families
for AKR7A2 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR001395 Aldo/ket_red

Graphical View of Domain Structure for InterPro Entry O43488

ProtoNet protein and cluster: O43488

UniProtKB/Swiss-Prot: ARK72_HUMAN, O43488
Similarity: Belongs to the aldo/keto reductase 2 family

Gene Function
for AKR7A2 gene

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Abnova Chimera RNAi Products for Gene knock-down (AKR7A2)
"" Origene 29mer shRNA kits in GFP-retroviral vector: AKR7A2
Origene shRNA RFP: AKR7A2
Origene basic RS shRNA: AKR7A2

""Applied Biosystems Silencer® siRNAs for AKR7A2
""Sigma-Aldrich siRNA Panels and siRNA for AKR7A2
Sigma-Aldrich shRNA for AKR7A2
Explore Sigma-Aldrich super-pooled esiRNAs
Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
""Browse iPSC Reprogramming Factors at Sigma-Aldrich
"" Origene GFP tagged cDNA clones in CMV expression vector: AKR7A2
Origene Myc/DDK tagged cDNA clones in CMV expression vector: AKR7A2
Origene untagged cDNA clones in CMV expression vector: AKR7A2
""Browse Sino Biological Human cDNA Clones  ""

UniProtKB/Swiss-Prot: ARK72_HUMAN, O43488
Function: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an
important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has
NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde
(in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde
protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver
against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen
Biophysicochemical properties: Kinetic parameters: KM=20 uM for succinic semialdehyde; KM=17 uM for
2-carboxybenzaldehyde; KM=8 uM for 9,10-phenanthrenequinone; KM=102 uM for 1,2-naphthoquinone;
Enzyme Number (IUBMB): EC 1.1.1.n11 

Genatlas biochemistry entry for AKR7A2:
aldo-ketoreductase 7,homolog of rattus norvegicus gene,expressed in
brain,heart,lung,prostate,skeletal,muscle,spleen,testis,stomach,pancreas,kidney,liver,also expressed in renal
carcinoma cells,involved in endogenous detoxication pathway,catalyzing the recuction of 2-carboxybenzaldehyde (2-CBA)
and related molecules

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004032 aldehyde reductase activity TAS9576847
GO:0009055 electron carrier activity TAS9576847
GO:0016491 oxidoreductase activity IEA--
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA--
About this table

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Animal Models: 1 MGI phenotypic allele "" for Akr7a5 (no phenotypes)


"" AKR7A2 for phenotypes           About GeneDecksing

Pathways & Interactions
for AKR7A2 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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"" AKR7A2 for pathways           About GeneDecksing

1 "" Millipore Pathway for AKR7A2
  ""  Naphthalene metabolism

5/6 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  AKR7A2  (Your Favorite Gene powered by Ingenuity) (see all 6 )
  ""  Galactose Metabolism
Glycerolipid Metabolism
Pyruvate Metabolism
NRF2-mediated Oxidative Stress Response
Fructose and Mannose Metabolism

"" Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AKR7A2

5/12 Interacting proteins for AKR7A2 (ENSP000002358353 O434882) via UniProtKB, MINT, and/or STRING (see all 12 ) ""
InteractantInteraction Details
GeneCardExternal ID(s)
AKR7A3O951542MINT-67373
CRYZENSP000003393993STRING: ENSP00000339399
HMOX1ENSP000002161173STRING: ENSP00000216117
CABP2ENSP000002942883STRING: ENSP00000294288
FOSENSP000003062453STRING: ENSP00000306245
About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005975 carbohydrate metabolic process TAS9576847
GO:0006081 cellular aldehyde metabolic process TAS9576847
GO:0055114 oxidation reduction IEA--
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Drugs & Compounds
for AKR7A2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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"" AKR7A2 for compounds           About GeneDecksing

"" Browse drugs & compounds from Enzo Life Sciences
""Browse Small Molecules at Sigma-Aldrich

"" Browse Tocris compounds for AKR7A2
10/31 ""Novoseek chemical compound relationships for AKR7A2 gene (see all 31 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
succinic semialdehyde 13.88 5 11597610 (2), 19164088 (1), 12604212 (1), 10510318 (1)
ethoxyquin 13.88 5 8665510 (2), 9823300 (1), 9679543 (1), 8923030 (1)
aflatoxin b1 11.81 7 8923030 (2), 18752886 (2), 18416522 (1), 12727802 (1) (see all 5)
3h-1,2-dithiole-3-thione 8.72 3 14555609 (2), 19695238 (1)
2-carboxybenzaldehyde 7.28 2 9576847 (1), 10510318 (1)
gamma-hydroxybutyrate 7.10 4 19164088 (1), 19013439 (1), 12071861 (1), 11597610 (1)
oltipraz 7.04 3 8923030 (1), 8665510 (1), 8538186 (1)
1,2-naphthoquinone 6.02 2 10510318 (2)
9,10-phenanthrenequinone 5.43 2 8665510 (1), 10510318 (1)
coumarin 5.22 3 10706111 (3)
About this table


Transcripts
for AKR7A2 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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  User Feedback
Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Abnova Chimera RNAi Products for Gene knock-down (AKR7A2)
""Applied Biosystems Silencer® siRNAs:  NM_003689  
"" Origene 29mer shRNA kits in GFP-retroviral vector: AKR7A2
Origene shRNA RFP: AKR7A2
Origene basic RS shRNA: AKR7A2

""Sigma-Aldrich siRNA Panels and siRNA for AKR7A2
Sigma-Aldrich shRNA for AKR7A2
Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:""Search SABiosciences for microRNAs that regulate AKR7A2: ""
Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
NM_003689  


Clones:"" Origene GFP tagged cDNA clones in CMV expression vector: AKR7A2
Origene Myc/DDK tagged cDNA clones in CMV expression vector: AKR7A2
Origene untagged cDNA clones in CMV expression vector: AKR7A2
Primers:"" Origene genome-wide validated SYBR primer pairs: AKR7A2
""SABiosciences RT2 qPCR Primer Assay for AKR7A2: PPH23419A ""

REFSEQ mRNAs for AKR7A2 gene: 

NM_003689.2  

Additional cDNA sequence: 

AF026947.1 AK225267.1 AK303131.1 BC004111.2 BC007352.2 BC010852.1 BC011586.1 BC012171.1 
BC013996.2 BT007347.1 CR597954.1 CR603343.1 CR606608.1 CR606766.1 CR610843.1 CR614593.1 
CR617181.1 CR618917.1 CR625016.1 Y16675.1 

10 DOTS entries:

DT.99981202  DT.316608  DT.95167811  DT.91771027  DT.121444740  DT.97847734  DT.97847733  DT.91939708 
DT.75116548  DT.91771037 

24/333 AceView cDNA sequences (see all 333 ):

NM_003689 CR606766 BI759101 BK000395 BQ435451 BI835445 BM829901 BM701761 
BU542750 CR606608 AA353925 BC011586 BX401279 AF026947 BU944847 BX281656 
AA422120 CR614593 BC013996 BQ021710 BQ233440 BM707873 Y16675 CR617181 

"" highest scoring ESTs for AKR7A2:

AF026947 AA054854 AA130934 AA459751 AI923514 AL577881 BE781162 BE784300 BE838741 BE873161 

Unigene Cluster for AKR7A2:

Aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
Hs.571886  [show with all ESTs]
Unigene Representative Sequence: NM_003689


GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for AKR7A2

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:                                                      
SP2:                    -                                 

About this scheme

ECgene alternative splicing isoforms for AKR7A2

6 Ensembl transcripts including schematic representations:
ENST00000424403  ENST00000235835  ENST00000489286  ENST00000481966  ENST00000492217  ENST00000330072  

Expression
for AKR7A2 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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AKR7A2 expression in normal and diseased human tissues

"" Applied Biosystems TaqMan ® Gene Expression Assays for AKR7A2

1""  / 2""  / 3""

5 probe-sets matching AKR7A2 gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
32510_at2, 3 U95-A 3 1.00 0.90 1.00 1.00 AF026947 1.00 0.90 0.95 1
214259_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI144075 0.20 1.00 0.72 1
202139_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003689 0.60 1.00 0.82 1
214259_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
202139_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
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Data from Genenote  (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CATTATTTTT

SOURCE GeneReport for Unigene cluster: Hs.571886

Expression variation in blood from EXPOLDB for AKR7A2

UniProtKB/Swiss-Prot: ARK72_HUMAN, O43488
Tissue specificity: Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate,
skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's
capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed

Primers:"" Origene genome-wide validated SYBR primer pairs: AKR7A2 ""
""SABiosciences RT2 qPCR Primer Assay for AKR7A2: PPH23419A ""

Orthologs
for AKR7A2 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for AKR7A2 gene from 5/9 species (see all 9 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 AKR7A21   -- aldo-keto reductase family 7, member A2 (aflatoxin more 87.47(n)
86.91(a)		 478210  XM_535385.2  XP_535385.2 
chimpanzee
(Pan troglodytes)		 AKR7A21   -- aldo-keto reductase family 7, member A2 (aflatoxin more 97.12(n)
96.1(a)		 748767  XM_001163068.1  XP_001163068.1 
cow
(Bos taurus)		 AKR7A21   -- aldo-keto reductase family 7, member A2 (aflatoxin more 85.57(n)
84.78(a)		 788425  XM_001255494.1  XP_001255495.1 
rat
(Rattus norvegicus)		 Akr7a21   -- aldo-keto reductase family 7, member A2 (aflatoxin more 86.71(n)
88.39(a)		 171445  NM_134407.1  NP_599234.1 
mouse
(Mus musculus)		 Akr7a51, 5 4 (66.80 cM)5
 aldo-keto reductase family 7, member A5 (aflatoxin more1, 5 85.98(n)1
88.58(a)1		 1101981  NM_025337.21  NP_079613.21 
 AF5253585  AI8400945  (see all 15)
About this table        Species with no ortholog for AKR7A2

ENSEMBL Gene Tree for AKR7A2

Paralogs
for AKR7A2 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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Paralogs for AKR7A2 gene
KCNAB12  AKR7A32  KCNAB32  AKR7L2  KCNAB22  

"" AKR7A2 for paralogs           About GeneDecksing


Pseudogenes
1 related pseudogene


Genomic Variants
for AKR7A2 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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10/31 NCBI SNPs in AKR7A2 are shown (see all 31 )
(Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 47)
ABGenomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
""
rs8592081,2
C,F,A19634964(-) TGCCAG/CCGGCT 2 /H /Q mis1 ref1 ese3""12Minor allele frequency- C:0.23MN NS EA NA WA 1196""
""
rs10436571,2
C,F19635011(-) TACACG/ACACCT 2 /T /A mis1 ref1 ese3""9Minor allele frequency- A:0.02NS EA NA 880""
--
rs22312031,2
C,F19633520(-) GAATAG/ACTGGG 2 /N /S mis1 ref1""4Minor allele frequency- A:0.03NS EA 406""
""
rs8592101,2
C,H19634705(-) TGGCCG/AAGATC 2 /K /E mis1 ref1""5Minor allele frequency- A:0.02MN NS EA 586""
""
rs66707591,2
H19635032(+) GTCCAC/TTTGGG 2 M V mis1 ref1 ese3""4Minor allele frequency- T:0.00NS EA 406""
""
rs22311921,2
F17885734(-) AGGAGC/TGTCCC 1 -- ng51""2Minor allele frequency- T:0.10MN EA 356""
--
rs22312071,2
C19630714(-) GGCCCA/GTCATG 1 -- ut31 ese3""0--------
""
rs22312001,2
C19633904(-) TGCAGG/AGCATG 2 /S /G mis1 ref1""4Minor allele frequency- A:0.00NS EA 406""
--
rs22312021,2
H19633531(-) CGCTTC/TTTTGG 2 F ref1 syn1 ese3""4Minor allele frequency- T:0.00NS EA 420""
--
rs37623941,2
C,F,A,H17882545(-) agtacC/Tcccaa 1 -- int1""7Minor allele frequency- T:0.17NA EA WA 218""
About this table

HapMap Linkage Disequilibrium images for AKR7A2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
      Database of Genomic Variants (DGV) variations for AKR7A2: --

Disorders & Mutations
for AKR7A2 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 603418

10/11 ""Novoseek disease relationships for AKR7A2 gene (see all 11 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
deficiency; selenium 2.06 1 9331086 (1)
pancreatic cancer 1.66 2 19077459 (2)
hepatocarcinogenesis 1.41 1 8923030 (1)
carcinogenicity 1.24 1 11764998 (1)
benign tumor 1.19 1 19077459 (1)
hepatotoxicity 1.12 1 11764998 (1)
neurodegenerative disease 0.93 1 11597610 (1)
carcinoma; renal cell 0.59 1 10510318 (1)
colorectal cancer 0.36 1 12879023 (1)
carcinoma hepatocellular 0.22 1 18752886 (1)
About this table

Medical News
for AKR7A2 gene

(Possibly Related Articles in Doctor's Guide)
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Publications
for AKR7A2 gene

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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  User Feedback		10/27 PubMed articles for AKR7A2 gene (see all 27 ):

Search for AKR7A2 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Genome Databases showing AKR7A2 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8574 HGNC: 389 AceView: AKR7A2andAKR7A3andAFAR3 Ensembl:ENSG00000053371 euGenes: HUgn8574
ECgene: AKR7A2 H-InvDB: AKR7A2

Other Databases showing AKR7A2 gene

(According to HUGE)
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Specialized Databases showing AKR7A2 gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
ATLAS Chromosomes in Cancer entry for AKR7A2 Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property
for AKR7A2 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
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  User Feedback		Patent Information for AKR7A2 gene: ""
Search GeneIP for patents involving AKR7A2

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Services
for AKR7A2 gene

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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