Aliases for AKR7A2 Gene
External Ids for AKR7A2 Gene
Previous GeneCards Identifiers for AKR7A2 Gene
The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
GeneCards Summary for AKR7A2 Gene
AKR7A2 (Aldo-Keto Reductase Family 7 Member A2) is a Protein Coding gene. Diseases associated with AKR7A2 include Gamma-Amino Butyric Acid Metabolism Disorder and Pancreatic Cystadenoma. Among its related pathways are Metabolism of xenobiotics by cytochrome P450 and Aflatoxin activation and detoxification. GO annotations related to this gene include electron carrier activity and phenanthrene-9,10-epoxide hydrolase activity. An important paralog of this gene is AKR7L.
UniProtKB/Swiss-Prot for AKR7A2 Gene
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.