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Aliases for AKR1E2 Gene

Aliases for AKR1E2 Gene

  • Aldo-Keto Reductase Family 1, Member E2 2 3
  • Aldo-Keto Reductase Family 1 Member C-Like Protein 2 3 4
  • Aldo-Keto Reductase Family 1, Member C-Like 2 2 3
  • Testis-Specific Protein 3 4
  • AF Reductase 3 4
  • EC 1.1.1.263 4 63
  • AKR1CL2 3 4
  • LoopADR 3 4
  • AKRDC1 3 4
  • HTSP 3 4
  • Aldo-Keto Reductase Family 1 Member E2 4
  • 1,5-Anhydro-D-Fructose Reductase 3
  • Aldo-Keto Reductase LoopADR 3
  • EC 1.1.1 63
  • HtAKR 3

External Ids for AKR1E2 Gene

Previous HGNC Symbols for AKR1E2 Gene

  • AKRDC1
  • AKR1CL2

Summaries for AKR1E2 Gene

Entrez Gene Summary for AKR1E2 Gene

  • The protein encoded by this gene is a member of the aldo-keto reductase superfamily. Members in this family are characterized by their structure (evolutionarily highly conserved TIM barrel) and function (NAD(P)H-dependent oxido-reduction of carbonyl groups). Transcripts of this gene have been reported in specimens of human testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for AKR1E2 Gene

AKR1E2 (Aldo-Keto Reductase Family 1, Member E2) is a Protein Coding gene. GO annotations related to this gene include 1,5-anhydro-D-fructose reductase activity. An important paralog of this gene is AKR1B1.

UniProtKB/Swiss-Prot for AKR1E2 Gene

  • Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. Can also catalyze the reduction of various aldehydes and quinones (By similarity). Has low NADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR1E2 Gene

Genomics for AKR1E2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AKR1E2 Gene

Start:
4,786,629 bp from pter
End:
4,854,130 bp from pter
Size:
67,502 bases
Orientation:
Plus strand

Genomic View for AKR1E2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKR1E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR1E2 Gene

No data available for Regulatory Elements for AKR1E2 Gene

Proteins for AKR1E2 Gene

  • Protein details for AKR1E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JD6-AKCL2_HUMAN
    Recommended name:
    1,5-anhydro-D-fructose reductase
    Protein Accession:
    Q96JD6
    Secondary Accessions:
    • Q86Z16
    • Q86Z17
    • Q86Z18
    • Q9BU71

    Protein attributes for AKR1E2 Gene

    Size:
    320 amino acids
    Molecular mass:
    36589 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AKR1E2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKR1E2 Gene

Proteomics data for AKR1E2 Gene at MOPED

Selected DME Specific Peptides for AKR1E2 Gene

Post-translational modifications for AKR1E2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for AKR1E2 Gene

Gene Families for AKR1E2 Gene

HGNC:
  • AKR :Aldo-keto reductases

Protein Domains for AKR1E2 Gene

Suggested Antigen Peptide Sequences for AKR1E2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JD6

UniProtKB/Swiss-Prot:

AKCL2_HUMAN :
  • Q96JD6
Family:
  • Belongs to the aldo/keto reductase family.
genes like me logo Genes that share domains with AKR1E2: view

Function for AKR1E2 Gene

Molecular function for AKR1E2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=6.1 uM for 9,10-phenanthrenequinone with NADPH as cofactor {ECO:0000269 PubMed:12604216}; Vmax=0.42 nmol/min/mg enzyme towards 9,10-phenanthrenequinone with NADPH as cofactor {ECO:0000269 PubMed:12604216};
UniProtKB/Swiss-Prot CatalyticActivity: 1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + NADPH
UniProtKB/Swiss-Prot Function: Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. Can also catalyze the reduction of various aldehydes and quinones (By similarity). Has low NADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro).

Enzyme Numbers (IUBMB) for AKR1E2 Gene

Gene Ontology (GO) - Molecular Function for AKR1E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity --
GO:0050571 1,5-anhydro-D-fructose reductase activity IEA --
genes like me logo Genes that share ontologies with AKR1E2: view

Phenotypes for AKR1E2 Gene

GenomeRNAi human phenotypes for AKR1E2:
genes like me logo Genes that share phenotypes with AKR1E2: view

Animal Model Products

CRISPR Products

miRNA for AKR1E2 Gene

miRTarBase miRNAs that target AKR1E2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for AKR1E2 Gene

Localization for AKR1E2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR1E2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKR1E2 Gene COMPARTMENTS Subcellular localization image for AKR1E2 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AKR1E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with AKR1E2: view

Pathways for AKR1E2 Gene

SuperPathways for AKR1E2 Gene

No Data Available

Interacting Proteins for AKR1E2 Gene

Gene Ontology (GO) - Biological Process for AKR1E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with AKR1E2: view

No data available for Pathways by source for AKR1E2 Gene

Transcripts for AKR1E2 Gene

Unigene Clusters for AKR1E2 Gene

Aldo-keto reductase family 1, member E2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKR1E2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for AKR1E2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKR1E2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - -
SP2: - -
SP3: -
SP4: - - - -
SP5: - - -
SP6: - - - - -
SP7:
SP8: - - -

Relevant External Links for AKR1E2 Gene

GeneLoc Exon Structure for
AKR1E2
ECgene alternative splicing isoforms for
AKR1E2

Expression for AKR1E2 Gene

mRNA expression in normal human tissues for AKR1E2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AKR1E2 Gene

This gene is overexpressed in Testis (12.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AKR1E2 Gene

SOURCE GeneReport for Unigene cluster for AKR1E2 Gene Hs.657944

mRNA Expression by UniProt/SwissProt for AKR1E2 Gene

Q96JD6-AKCL2_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expressions with AKR1E2: view

In Situ Assay Products

Orthologs for AKR1E2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AKR1E2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKR1E2 35
  • 99.06 (n)
  • 98.75 (a)
AKR1E2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AKR1E2 35
  • 79.46 (n)
  • 73.06 (a)
AKR1E2 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKR1E2 35
  • 79.51 (n)
  • 75.75 (a)
AKR1E2 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akr1e1 35
  • 78.96 (n)
  • 74.75 (a)
Akr1e1 16
Akr1e1 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AKR1E2 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Akr1e2 35
  • 78.63 (n)
  • 75.42 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 46 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
AKR 36
  • 59 (a)
OneToMany
AKR1B1L 36
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii akr1b1 36
  • 55 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6084 36
  • 47 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G01670 35
  • 48.47 (n)
  • 41.39 (a)
rice
(Oryza sativa)
Liliopsida Os05g0474600 35
  • 50.63 (n)
  • 40.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for AKR1E2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKR1E2 Gene

ENSEMBL:
Gene Tree for AKR1E2 (if available)
TreeFam:
Gene Tree for AKR1E2 (if available)

Paralogs for AKR1E2 Gene

Paralogs for AKR1E2 Gene

Selected SIMAP similar genes for AKR1E2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for AKR1E2 Gene

genes like me logo Genes that share paralogs with AKR1E2: view

Variants for AKR1E2 Gene

Sequence variations from dbSNP and Humsavar for AKR1E2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs752534 -- 4,847,953(+) TGACC(C/T)CCAGG utr-variant-3-prime, nc-transcript-variant, intron-variant
rs1005907 -- 4,830,914(+) TTCTT(C/T)ATGGG intron-variant
rs1078062 -- 4,848,532(-) CCAAG(A/G)GCCTG downstream-variant-500B, intron-variant
rs1078063 -- 4,848,355(-) GCAGG(A/G)CCTCC downstream-variant-500B, intron-variant
rs1869214 -- 4,847,578(-) CCAAT(A/G)GTGTC utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKR1E2 Gene

Variant ID Type Subtype PubMed ID
nsv894783 CNV Loss 21882294
nsv894792 CNV Gain 21882294
esv4850 CNV Deletion 18987735
esv2665522 CNV Deletion 23128226

Relevant External Links for AKR1E2 Gene

HapMap Linkage Disequilibrium report
AKR1E2
Human Gene Mutation Database (HGMD)
AKR1E2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKR1E2 Gene

Disorders for AKR1E2 Gene

Relevant External Links for AKR1E2

Genetic Association Database (GAD)
AKR1E2
Human Genome Epidemiology (HuGE) Navigator
AKR1E2
genes like me logo Genes that share disorders with AKR1E2: view

No data available for UniProtKB/Swiss-Prot for AKR1E2 Gene

Publications for AKR1E2 Gene

  1. Human testis specific protein: a new member of aldo-keto reductase superfamily. (PMID: 12604216) Nishinaka T. … Yabe-Nishimura C. (Chem. Biol. Interact. 2003) 3 4
  2. Characterization of htAKR, a novel gene product in the aldo-keto reductase family specifically expressed in human testis. (PMID: 15118078) Azuma Y. … Miki T. (Mol. Hum. Reprod. 2004) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for AKR1E2 Gene

Sources for AKR1E2 Gene

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