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AKR1E2 Gene

protein-coding   GIFtS: 50
GCID: GC10P004829

Aldo-Keto Reductase Family 1, Member E2

(Previous names: aldo-keto reductase family 1, member C-like 2)
(Previous symbols: AKRDC1, AKR1CL2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aldo-Keto Reductase Family 1, Member E21 2     hTSP2 3
AKR1CL21 2 3     EC 1.1.1.2633 8
AKRDC11 2 3     1,5-Anhydro-D-Fructose Reductase2
Aldo-Keto Reductase Family 1, Member C-Like 21 2     Aldo-Keto Reductase LoopADR2
Aldo-Keto Reductase Family 1 Member C-Like Protein 22 3     htAKR2
Testis-Specific Protein2 3     Aldo-Keto Reductase Family 1 Member E23
LoopADR2 3     EC 1.1.18
AF Reductase2 3     

External Ids:    HGNC: 234371   Entrez Gene: 835922   Ensembl: ENSG000001655687   UniProtKB: Q96JD63   

Export aliases for AKR1E2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AKR1E2 Gene:
The protein encoded by this gene is a member of the aldo-keto reductase superfamily. Members in this family are
characterized by their structure (evolutionarily highly conserved TIM barrel) and function (NAD(P)H-dependent
oxido-reduction of carbonyl groups). Transcripts of this gene have been reported in specimens of human testis.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for AKR1E2 Gene:
AKR1E2 (aldo-keto reductase family 1, member E2) is a protein-coding gene. Diseases associated with AKR1E2 include food allergy, and alzheimer's disease. GO annotations related to this gene include 1,5-anhydro-D-fructose reductase activity. An important paralog of this gene is AKR1C2.

UniProtKB/Swiss-Prot: AKCL2_HUMAN, Q96JD6
Function: Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. Can
also catalyze the reduction of various aldehydes and quinones (By similarity). Has low NADPH-dependent reductase
activity towards 9,10-phenanthrenequinone (in vitro)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_008705.17  NC_018921.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for AKR1E2
         Other transcription factors

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   Search Chromatin IP Primers for AKR1E2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKR1E2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.1   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15.2

AKR1E2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKR1E2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P004829:  view genomic region     (about GC identifiers)

Start:
4,828,821 bp from pter      End:
4,890,254 bp from pter
Size:
61,434 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AKCL2_HUMAN, Q96JD6 (See protein sequence)
Recommended Name: 1,5-anhydro-D-fructose reductase  
Size: 320 amino acids; 36589 Da
Secondary accessions: Q86Z16 Q86Z17 Q86Z18 Q9BU71
Alternative splicing: 5 isoforms:  Q96JD6-1   Q96JD6-2   Q96JD6-3   Q96JD6-4   Q96JD6-5   

Explore the universe of human proteins at neXtProt for AKR1E2: NX_Q96JD6

Explore proteomics data for AKR1E2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for AKR1E2 (Q96JD6) (see all 6)
     NIQVFDF  AIDAGYRH  NQIECHPYL  KLWCTCHKKSLV 


    See AKR1E2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035267.1  NP_001257950.1  NP_001257954.1  

    ENSEMBL proteins: 
     ENSP00000435436   ENSP00000434437   ENSP00000436794   ENSP00000298375   ENSP00000432947  
     ENSP00000335603   ENSP00000335034   ENSP00000433496   ENSP00000431625  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AKR: Aldo-keto reductases

    4 InterPro protein domains:
     IPR001395 Aldo/ket_red
     IPR018170 Aldo/ket_reductase_CS
     IPR020471 Aldo/keto_reductase_subgr
     IPR023210 NADP_OxRdtase_dom

    Graphical View of Domain Structure for InterPro Entry Q96JD6

    ProtoNet protein and cluster: Q96JD6

    1 Blocks protein domain: IPB001395 Aldo/keto reductase

    UniProtKB/Swiss-Prot: AKCL2_HUMAN, Q96JD6
    Similarity: Belongs to the aldo/keto reductase family


    AKR1E2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKCL2_HUMAN, Q96JD6
    Function: Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. Can
    also catalyze the reduction of various aldehydes and quinones (By similarity). Has low NADPH-dependent reductase
    activity towards 9,10-phenanthrenequinone (in vitro)
    Catalytic activity: 1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + NADPH
    Biophysicochemical properties: Kinetic parameters: KM=6.1 uM for 9,10-phenanthrenequinone with NADPH as cofactor;
    Vmax=0.42 nmol/min/mg enzyme towards 9,10-phenanthrenequinone with NADPH as cofactor;

         Enzyme Numbers (IUBMB): EC 1.1.1.2631 2 EC 1.1.12

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491oxidoreductase activity ----
    GO:00505711,5-anhydro-D-fructose reductase activity IEA--
         
    AKR1E2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AKR1E2:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AKR1E2
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    miRNA
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    miRTarBase miRNAs that target AKR1E2:
    hsa-mir-335-5p (MIRT018529)

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    1 qRT-PCR Assays for microRNA that regulate AKR1E2:
    hsa-miR-3611
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AKCL2_HUMAN, Q96JD6: Cytoplasm (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    AKR1E2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AKR1E2
    Interactions:

        Search GeneGlobe Interaction Network for AKR1E2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for AKR1E2 (ENSP000002983754) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC4ENSP000003154764STRING: ENSP00000315476
    GLO1ENSP000003624634STRING: ENSP00000362463
    MCEEENSP000002442174STRING: ENSP00000244217
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AKR1E2 (AKCL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AKR1E2 gene (4 alternative transcripts): 
    NM_001040177.2  NM_001271021.1  NM_001271025.1  NM_031436.2  

    Unigene Cluster for AKR1E2:

    Aldo-keto reductase family 1, member E2
    Hs.657944  [show with all ESTs]
    Unigene Representative Sequence: NR_073125
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533295 ENST00000462718 ENST00000474119 ENST00000463345(uc001ihh.1 uc001ihi.3 uc001ihj.3 uc001ihk.3 uc009xhw.3)
    ENST00000298375 ENST00000525281(uc010qam.1) ENST00000525627 ENST00000532248
    ENST00000345253 ENST00000334019 ENST00000441590 ENST00000525572 ENST00000487985

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate AKR1E2:
    hsa-miR-3611
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      QuantiTect SYBR Green Assays in human, mouse, rat AKR1E2
      QuantiFast Probe-based Assays in human, mouse, rat AKR1E2

    Additional mRNA sequence: 

    AB040820.1 AB040821.1 AB040822.1 AB055603.1 AF263242.1 AK074211.1 AK302155.1 BC002862.2 
    BC023972.1 NR_073125.1 NR_073126.1 NR_073127.1 

    9 DOTS entries:

    DT.200215  DT.40282105  DT.97835014  DT.100778414  DT.100778415  DT.100778416  DT.91674634  DT.121225001 
    DT.97799450 

    Selected AceView cDNA sequences (see all 413):

    AB040821 AI203621 AA962456 CB123890 CB122143 AF263242 BU630856 CB108084 
    BU732460 F03084 BU158378 AI205722 CB108102 D26124 BQ217413 AA905825 
    BM981653 CB108557 CB107086 BM987467 BM975984 CB107984 CB121334 CA425039 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AKR1E2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:              -                       -                                                         
    SP2:                                      -                                         -               
    SP3:                                      -                                                         
    SP4:                                      -                 -     -                 -               
    SP5:                                      -                 -     -                                 


    ECgene alternative splicing isoforms for AKR1E2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AKR1E2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATATGGC
    AKR1E2 Expression
    About this image


    AKR1E2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Testis (Reproductive System)
    AKR1E2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKR1E2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657944

    UniProtKB/Swiss-Prot: AKCL2_HUMAN, Q96JD6
    Tissue specificity: Testis-specific

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AKR1E2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akr1e11 , 5 aldo-keto reductase family 1, member E11, 5 78.96(n)1
    74.75(a)1
      13 (2.57 cM)5
    560431  NM_018859.21  NP_061347.21 
     45907575 
    chicken
    (Gallus gallus)
    Aves AKR6
    --
    (see all 6)
    Uncharacterized protein
    (see all 6)
    59(a)
    58(a)
    (see all 6)
    1 ↔ many
    1 ↔ many
    (see all 6)
    1(62590066-62598178)
    1(62261360-62268585)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    60(a)
    59(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    5(14709667-14721503)
    5(14432738-14461535)
    zebrafish
    (Danio rerio)
    Actinopterygii akr1b16
    aldo-keto reductase family 1, member B1 (aldose re...
    55(a)
    many ↔ many
    4(13965434-13971908) ENSDARG00000006215
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60846
    --
    47(a)
    1 → many
    3L(11613635-11617481)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G016701 AT5G01670 48.47(n)
    41.39(a)
      831701  NM_120245.3  NP_195787.2 
    rice
    (Oryza sativa)
    Liliopsida Os05g04746001 Os05g0474600 50.63(n)
    40.98(a)
      4339090  NM_001062361.1  NP_001055826.1 


    ENSEMBL Gene Tree for AKR1E2 (if available)
    TreeFam Gene Tree for AKR1E2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AKR1E2 gene
    AKR1C22  AKR1CL12  AKR1C32  AKR1B102  AKR1A12  AKR1C42  AKR1B152  AKR1B12  
    AKR1D12  AKR1C12  
    11 SIMAP similar genes for AKR1E2 using alignment to 5 protein entries:     AKCL2_HUMAN (see all proteins):
    AKR1B10    AKR1B1    AKR1B15    LOC402299    AKR1C3    AKR1C1
    AKR1C4    AKR1CL1    AKR1C2    AKR1A1    AKR1D1

    AKR1E2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for AKR1E2
    PGOHUM00000238337


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AKR1E2 (see all 786)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs109043501,2
    C,F,A,H--4866433(+) TGGTGC/TACCCA 6 -- us2k114Minor allele frequency- T:0.16NS EA NA WA 782
    rs1501179571,2
    --4866444(+) TCACCA/TGAGTA 6 -- us2k10--------
    rs29615611,2
    C,F,A--4866482(+) TTTATG/CTCTCA 6 -- us2k1 tfbs311Minor allele frequency- C:0.22NA WA CSA EA 374
    rs112527651,2
    C--4866568(+) TACAAC/TATCAA 6 -- us2k1 tfbs30--------
    rs1140955941,2
    C,F--4866740(+) ATACAC/TAAAGA 6 -- us2k11Minor allele frequency- T:0.01WA 118
    rs765572081,2
    C,F--4866747(+) AAGAAC/TTCTTA 6 -- us2k13Minor allele frequency- T:0.07WA NA 240
    rs763097561,2
    C,F--4866865(+) CTCAAC/TGTCAT 6 -- us2k11Minor allele frequency- T:0.10EA 120
    rs1177107691,2
    F--4867202(+) CACTGC/TACCCT 6 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1492457081,2
    --4867218(+) AACTTG/TCCCCG 6 -- us2k10--------
    rs29615621,2
    C,F,A--4867313(+) CATTGT/AGGAGA 6 -- us2k113Minor allele frequency- A:0.25NA WA CSA 259

    HapMap Linkage Disequilibrium report for AKR1E2 (4828821 - 4890254 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for AKR1E2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665522CNV Deletion23128226
    esv4850CNV Deletion18987735
    nsv894783CNV Loss21882294
    nsv894792CNV Gain21882294

    Human Gene Mutation Database (HGMD): AKR1E2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AKR1E2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for AKR1E2:    
    About MalaCards
    food allergy    alzheimer's disease


    AKR1E2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AKR1E2
    Human Genome Epidemiology (HuGE) Navigator: AKR1E2 (0 documents)

    Export disorders for AKR1E2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AKR1E2 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with AKR1E2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human testis specific protein: a new member of aldo-keto reductase superfamily. (PubMed id 12604216)1, 2 Nishinaka T.... Yabe-Nishimura C. (Chem. Biol. Interact. 2003)
    2. Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus. (PubMed id 20662065)1 Clancy R.M....Buyon J.P. (Arthritis Rheum. 2010)
    3. Aldo-keto reductase (AKR) superfamily: genomics and annotation. (PubMed id 19706366)1 Mindnich R.D. and Penning T.M. (Hum. Genomics 2009)
    4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)
    10. Characterization of htAKR, a novel gene product in the aldo-keto reductase family specifically expressed in human testis. (PubMed id 15118078)1 Azuma Y....Miki T. (Mol. Hum. Reprod. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 83592 HGNC: 23437 AceView: AKR1C1andAKR1CL2 Ensembl:ENSG00000165568 euGenes: HUgn83592
    ECgene: AKR1E2 H-InvDB: AKR1E2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AKR1E2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AKR1E2 gene:
    Search GeneIP for patents involving AKR1E2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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