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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AKR1CL1 Gene

protein-coding   GIFtS: 35
GCID: GC10M005196

Aldo-Keto Reductase Family 1, Member C-Like 1

  Search for AKR1CL1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Aldo-Keto Reductase Family 1, Member C-Like 11 2
EC 1.1.1.-3

External Ids:    HGNC: 234691   Entrez Gene: 3408112   Ensembl: ENSG000001963267   UniProtKB: Q5T2L23   

Export aliases for AKR1CL1 gene to outside databases

Previous GC identifers: GC10M005151 GC10M005192 GC10M005130


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AKR1CL1 Gene: 
AKR1CL1 (aldo-keto reductase family 1, member C-like 1) is a protein-coding gene. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is AKR1C2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AKR1CL1 gene promoter:
         HFH-3   STAT1   FOXF2   Pax-6   HNF-4alpha2   HNF-4alpha1   Evi-1   C/EBPalpha   FOXI1   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAKR1CL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AKR1CL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKR1CL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.1   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15.2

AKR1CL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKR1CL1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M005196:  view genomic region     (about GC identifiers)

Start:
5,196,335 bp from pter      End:
5,244,449 bp from pter
Size:
48,115 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AKCL1_HUMAN, Q5T2L2 (See protein sequence)
Recommended Name: Aldo-keto reductase family 1 member C-like protein 1  
Size: 129 amino acids; 14588 Da
Subcellular location: Cytoplasm (Potential)
Secondary accessions: A6NF66 Q6ZN81

Explore the universe of human proteins at neXtProt for AKR1CL1: NX_Q5T2L2

Explore proteomics data for AKR1CL1 at MOPED 

AKR1CL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

AKR1CL1 Protein Expression

ENSEMBL proteins: 
 ENSP00000417959   ENSP00000417935   ENSP00000334626   ENSP00000394055  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--

AKR1CL1 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR001395 Aldo/ket_red
 IPR018170 Aldo/ket_reductase_CS
 IPR020471 Aldo/keto_reductase_subgr
 IPR023210 NADP_OxRdtase_dom

Graphical View of Domain Structure for InterPro Entry Q5T2L2

ProtoNet protein and cluster: Q5T2L2

UniProtKB/Swiss-Prot: AKCL1_HUMAN, Q5T2L2
Similarity: Belongs to the aldo/keto reductase family


AKR1CL1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Enzyme Number (IUBMB): EC 1.1.1.-1

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016491oxidoreductase activity IEA--
     
AKR1CL1 for ontologies           About GeneDecksing


Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AKR1CL1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AKR1CL1 (AKCL1)

Search CenterWatch for drugs/clinical trials and news about AKR1CL1 / AKCL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AKR1CL1 gene: 
NM_001007536.3  

Unigene Cluster for AKR1CL1:

Aldo-keto reductase family 1, member C-like 1
Hs.282513  [show with all ESTs]
Unigene Representative Sequence: NR_027916
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000473890 ENST00000465430(uc009xhz.2) ENST00000488756 ENST00000472691
ENST00000334314 ENST00000445191
miRNA
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Additional mRNA sequence: 

BC101204.1 BC101205.1 NR_027916.1 

2 DOTS entries:

DT.91990097  DT.91997357 

5 AceView cDNA sequences:

AV652976 AV652918 AK131335 AV719141 AV719030 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AKR1CL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TACCATTTGC
AKR1CL1 Expression
About this image


See AKR1CL1 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.282513
    SABiosciences Custom PCR Arrays for AKR1CL1
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKR1CL1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for AKR1CL1 gene from 6/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia AKR1C36
aldo-keto reductase family 1 member C21
29(a)
1 ↔ 1
2(30674558-30690076)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
19(a)
possible ortholog
AAWZ02039178(2232-9123)
zebrafish
(Danio rerio)
Actinopterygii zgc:566226
zgc:56622
15(a)
possible ortholog
18(12660381-12669534)
fruit fly
(Drosophila melanogaster)
Insecta CG127666
CG106386
(see all 7)
--
21(a)
21(a)
(see all 7)
possible ortholog
possible ortholog
(see all 7)
3L(3938624-3940125)
3L(12491504-12494411)
worm
(Caenorhabditis elegans)
Secernentea C07D8.56
Y39G8B.16
(see all 6)
Protein Y39G8B.1, isoform b
(see all 6)
24(a)
18(a)
(see all 6)
possible ortholog
possible ortholog
(see all 6)
X(7344047-7344551)
II(13970583-13972946)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRE36
Aldose reductase involved in methylglyoxal, d-xylo...
16(a)
1 → many
VIII(323409-324392)


ENSEMBL Gene Tree for AKR1CL1 (if available)
TreeFam Gene Tree for AKR1CL1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for AKR1CL1 gene
AKR1C22  AKR1C32  AKR1B102  AKR1A12  AKR1C42  AKR1E22  AKR1B152  AKR1B12  
AKR1D12  AKR1C12  
11 SIMAP similar genes for AKR1CL1 using alignment to 4 protein entries:     AKCL1_HUMAN (see all proteins):
AKR1C3    AKR1C4    AKR1C2    AKR1C1    AKR1D1    AKR1B1
AKR1B15    AKR1B10    LOC402299    AKR1E2    AKR1A1

AKR1CL1 for paralogs           About GeneDecksing


3 Pseudogenes.org Pseudogenes for AKR1CL1
PGOHUM00000258457 PGOHUM00000238336 PGOHUM00000238338


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/208 SNPs in AKR1CL1 are shown (see all 208)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0323554
----see VAR_0323552 R H mis40--------
rs57828111,2
C--5118745(+) AATAGGAG/-TTTTT 1 -- int12Minor allele frequency- -:0.00NA CSA 4
rs1395457421,2
C--5196272(+) AATACC/TAAAAT 1 -- ds50010--------
rs1489346661,2
C--5197139(+) GAGGAA/TCCAGA 1 -- nc-transcript-variant0--------
rs781587401,2
F--5198760(+) TATCTA/TATGTA 1 -- int12Minor allele frequency- T:0.09NA EA 240
rs342844021,2
C--5198761(+) TCTAA-/TCTAT 
CTA
/TCTT
TGTAT
1 -- int10--------
rs1429210711,2
C--5200075(+) TTCCCC/TAAATT 1 -- int10--------
rs1414065011,2
C--5201427(+) AAATTC/TGCATG 1 -- int10--------
rs17615991,2
C,F--5202241(-) TGCATA/GTCTCA 1 -- int19Minor allele frequency- G:0.22NA WA CSA 153
rs1386236811,2
C--5206691(+) TTTCAC/TGGAAG 1 -- int10--------

HapMap Linkage Disequilibrium report for AKR1CL1 (5196335 - 5244449 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for AKR1CL1:    About this table     
Variant IDTypeSubtypePubMed ID
esv2731707CNV Deletion23290073
esv4943CNV Deletion18987735
esv1007439CNV Deletion20482838
esv1074345CNV Insertion17803354
esv988429CNV Insertion20482838
esv2484274CNV Insertion19546169
esv1314667CNV Insertion17803354
nsv894783CNV Loss21882294
nsv894792CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for AKR1CL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with AKR1CL1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2, 3 Deloukas P.... Rogers J. (2004)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 340811 HGNC: 23469 AceView: AKR1CL1 Ensembl:ENSG00000196326 euGenes: HUgn340811
ECgene: AKR1CL1 H-InvDB: AKR1CL1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for AKR1CL1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for AKR1CL1 gene:
Search GeneIP for patents involving AKR1CL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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