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Aliases for AKR1C8P Gene

Aliases for AKR1C8P Gene

  • Aldo-Keto Reductase Family 1 Member C8, Pseudogene 2 3 5
  • Aldo-Keto Reductase Family 1, Member C-Like 1 2 3
  • AKR1CL1 3 4
  • Aldo-Keto Reductase Family 1 Member C-Like Protein 1 4
  • Protein RAKc 3
  • EC 1.1.1.- 4

External Ids for AKR1C8P Gene

Previous HGNC Symbols for AKR1C8P Gene

  • AKR1CL1

Summaries for AKR1C8P Gene

GeneCards Summary for AKR1C8P Gene

AKR1C8P (Aldo-Keto Reductase Family 1 Member C8, Pseudogene) is a Pseudogene. GO annotations related to this gene include oxidoreductase activity.

Additional gene information for AKR1C8P Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR1C8P Gene

Genomics for AKR1C8P Gene

Regulatory Elements for AKR1C8P Gene

Enhancers for AKR1C8P Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H005093 1.2 Ensembl ENCODE 17.1 +90.0 89993 2 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS MXD4 NFYC AKR1C8P RBM17 AKR1C3 ENSG00000239142 AKR1C5P
GH10H005146 1 ENCODE 18.1 +37.3 37274 2 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ATF7 SP5 MXD4 REST AKR1C8P AKR1C4 ARL4AP3 UCN3 AKR1C3 AKR1C5P
GH10H005089 0.7 ENCODE 17.9 +95.2 95154 0 GATAD2A CTCF FOXA2 NFIA NFIB FOXA3 DPF2 ZNF644 RAD21 FOXA1 AKR1C8P ENSG00000239142 PIR40953
GH10H005234 1.2 Ensembl ENCODE 4.8 -49.3 -49315 0 FOXA2 ARID4B YY1 MIER2 PPARG KAT8 PPARGC1A NFIL3 SSRP1 MIER3 LINC02561 AKR1C8P ENSG00000231039
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AKR1C8P on UCSC Golden Path with GeneCards custom track

Genomic Location for AKR1C8P Gene

Chromosome:
10
Start:
5,154,143 bp from pter
End:
5,185,187 bp from pter
Size:
31,045 bases
Orientation:
Minus strand

Genomic View for AKR1C8P Gene

Genes around AKR1C8P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKR1C8P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKR1C8P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR1C8P Gene

Proteins for AKR1C8P Gene

  • Protein details for AKR1C8P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T2L2-AKCL1_HUMAN
    Recommended name:
    Putative aldo-keto reductase family 1 member C8
    Protein Accession:
    Q5T2L2
    Secondary Accessions:
    • A6NF66
    • Q6ZN81

    Protein attributes for AKR1C8P Gene

    Size:
    129 amino acids
    Molecular mass:
    14588 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AKR1C8P Gene

Post-translational modifications for AKR1C8P Gene

No Post-translational modifications

No data available for DME Specific Peptides for AKR1C8P Gene

Domains & Families for AKR1C8P Gene

Protein Domains for AKR1C8P Gene

Suggested Antigen Peptide Sequences for AKR1C8P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T2L2

UniProtKB/Swiss-Prot:

AKCL1_HUMAN :
  • Belongs to the aldo/keto reductase family.
Family:
  • Belongs to the aldo/keto reductase family.
genes like me logo Genes that share domains with AKR1C8P: view

No data available for Gene Families for AKR1C8P Gene

Function for AKR1C8P Gene

Enzyme Numbers (IUBMB) for AKR1C8P Gene

Phenotypes From GWAS Catalog for AKR1C8P Gene

Gene Ontology (GO) - Molecular Function for AKR1C8P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with AKR1C8P: view
genes like me logo Genes that share phenotypes with AKR1C8P: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for AKR1C8P
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AKR1C8P Gene

Localization for AKR1C8P Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR1C8P Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKR1C8P gene
Compartment Confidence
cytosol 3
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for AKR1C8P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with AKR1C8P: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AKR1C8P Gene

Pathways & Interactions for AKR1C8P Gene

SuperPathways for AKR1C8P Gene

No Data Available

Interacting Proteins for AKR1C8P Gene

Gene Ontology (GO) - Biological Process for AKR1C8P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with AKR1C8P: view

No data available for Pathways by source and SIGNOR curated interactions for AKR1C8P Gene

Drugs & Compounds for AKR1C8P Gene

No Compound Related Data Available

Transcripts for AKR1C8P Gene

mRNA/cDNA for AKR1C8P Gene

(1) REFSEQ mRNAs :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for AKR1C8P
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for AKR1C8P Gene

No ASD Table

Relevant External Links for AKR1C8P Gene

GeneLoc Exon Structure for
AKR1C8P
ECgene alternative splicing isoforms for
AKR1C8P

Expression for AKR1C8P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AKR1C8P Gene

Protein differential expression in normal tissues from HIPED for AKR1C8P Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AKR1C8P Gene



Protein tissue co-expression partners for AKR1C8P Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AKR1C8P Gene:

AKR1C8P
genes like me logo Genes that share expression patterns with AKR1C8P: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKR1C8P Gene

Orthologs for AKR1C8P Gene

Evolution for AKR1C8P Gene

ENSEMBL:
Gene Tree for AKR1C8P (if available)
TreeFam:
Gene Tree for AKR1C8P (if available)

No data available for Orthologs for AKR1C8P Gene

Paralogs for AKR1C8P Gene

No data available for Paralogs for AKR1C8P Gene

Variants for AKR1C8P Gene

Sequence variations from dbSNP and Humsavar for AKR1C8P Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000019874 -- 5,184,023(+) TCCTT(C/T)TGTGG intron-variant
rs1000075824 -- 5,179,540(+) GATTG(A/C/G)AGAAG intron-variant
rs1000107726 -- 5,156,709(+) AAATG(A/G)GCATT intron-variant
rs1000205404 -- 5,160,525(+) TCCTT(C/T)TGTGC intron-variant
rs1000435805 -- 5,165,482(+) TCTAA(C/T)AGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKR1C8P Gene

Variant ID Type Subtype PubMed ID
dgv172e212 CNV loss 25503493
dgv350n106 CNV deletion 24896259
esv1007439 CNV deletion 20482838
esv1074345 CNV insertion 17803354
esv1314667 CNV insertion 17803354
esv2484274 CNV insertion 19546169
esv2731707 CNV deletion 23290073
esv2763913 CNV gain+loss 21179565
esv2865791 CNV insertion 24192839
esv3351321 CNV duplication 20981092
esv3622221 CNV loss 21293372
esv3622222 CNV gain 21293372
esv3622223 CNV gain 21293372
esv3622224 CNV gain 21293372
esv3622225 CNV loss 21293372
esv4943 CNV loss 18987735
esv988429 CNV insertion 20482838
nsv1036566 CNV loss 25217958
nsv1039386 CNV gain 25217958
nsv1045155 CNV loss 25217958
nsv1048081 CNV loss 25217958
nsv1050246 CNV gain 25217958
nsv1069010 CNV deletion 25765185
nsv1069447 CNV deletion 25765185
nsv1115385 CNV duplication 24896259
nsv1122484 CNV deletion 24896259
nsv1149325 CNV deletion 26484159
nsv549881 CNV loss 21841781
nsv549882 CNV loss 21841781
nsv549883 CNV loss 21841781
nsv549886 CNV loss 21841781

Variation tolerance for AKR1C8P Gene

Gene Damage Index Score: 7.10; 80.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKR1C8P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKR1C8P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKR1C8P Gene

Disorders for AKR1C8P Gene

Relevant External Links for AKR1C8P

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKR1C8P

No disorders were found for AKR1C8P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKR1C8P Gene

Publications for AKR1C8P Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for AKR1C8P Gene

Sources for AKR1C8P Gene

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