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Aliases for AKR1C4 Gene

Aliases for AKR1C4 Gene

  • Aldo-Keto Reductase Family 1 Member C4 2 3 5
  • Chlordecone Reductase; 3-Alpha Hydroxysteroid Dehydrogenase, Type I; Dihydrodiol Dehydrogenase 4 2 3
  • 3-Alpha-HSD1 3 4
  • HAKRA 3 4
  • CHDR 3 4
  • DD-4 3 4
  • CDR 3 4
  • DD4 3 4
  • Aldo-Keto Reductase Family 1, Member C4 (Chlordecone Reductase; 3-Alpha Hydroxysteroid Dehydrogenase, Type I; Dihydrodiol Dehydrogenase 4) 2
  • Type I 3-Alpha-Hydroxysteroid Dehydrogenase 3
  • 3-Alpha-Hydroxysteroid Dehydrogenase Type I 4
  • Dihydrodiol Dehydrogenase Isozyme DD4 3
  • Dihydrodiol Dehydrogenase 4 4
  • Chlordecone Reductase 4
  • EC 1.1.1.274 61
  • EC 1.1.1.357 4
  • EC 1.1.1.225 4
  • 3-Alpha-HSD 3
  • EC 1.1.1.- 4
  • EC 1.1.1 61
  • C11 3

External Ids for AKR1C4 Gene

Previous HGNC Symbols for AKR1C4 Gene

  • CHDR

Previous GeneCards Identifiers for AKR1C4 Gene

  • GC10P005286
  • GC10P005105
  • GC10P005091
  • GC10P005092
  • GC10P005228

Summaries for AKR1C4 Gene

Entrez Gene Summary for AKR1C4 Gene

  • This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKR1C4 Gene

AKR1C4 (Aldo-Keto Reductase Family 1 Member C4) is a Protein Coding gene. Diseases associated with AKR1C4 include 46Xy Sex Reversal 8 and Prostate Cancer. Among its related pathways are Metabolism of fat-soluble vitamins and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include electron carrier activity and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. An important paralog of this gene is AKR1C3.

UniProtKB/Swiss-Prot for AKR1C4 Gene

  • Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.

Gene Wiki entry for AKR1C4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR1C4 Gene

Genomics for AKR1C4 Gene

Regulatory Elements for AKR1C4 Gene

Enhancers for AKR1C4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F005146 1 ENCODE 12.2 -47.5 -47549 2.5 MLX ARID4B DMAP1 YY1 SLC30A9 SP5 MXD4 PPARG KAT8 SSRP1 AKR1C8P AKR1C4 ARL4AP3 UCN3 AKR1C3 AKR1C5P
GH10F005272 0.6 FANTOM5 12.1 +77.1 77071 0.1 CEBPB NFE2 EMSY AKR1C4 UCN3 ENSG00000224034 AKR1C7P
GH10F005195 0.8 ENCODE 0.8 +1.1 1082 2.1 ELF3 THRB RAD21 RARA YY1 CREM MIXL1 CEBPB PPARG KAT8 TUBAL3 RBM17 AKR1C3 AKR1C4 ARL4AP3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AKR1C4 on UCSC Golden Path with GeneCards custom track

Genomic Location for AKR1C4 Gene

Chromosome:
10
Start:
5,195,462 bp from pter
End:
5,220,633 bp from pter
Size:
25,172 bases
Orientation:
Plus strand

Genomic View for AKR1C4 Gene

Genes around AKR1C4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKR1C4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKR1C4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR1C4 Gene

Proteins for AKR1C4 Gene

  • Protein details for AKR1C4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17516-AK1C4_HUMAN
    Recommended name:
    Aldo-keto reductase family 1 member C4
    Protein Accession:
    P17516
    Secondary Accessions:
    • Q5T6A3
    • Q8WW84
    • Q9NS54

    Protein attributes for AKR1C4 Gene

    Size:
    323 amino acids
    Molecular mass:
    37067 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAA35658.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AKR1C4 Gene

neXtProt entry for AKR1C4 Gene

Selected DME Specific Peptides for AKR1C4 Gene

P17516:
  • SLKKLQLDY
  • KSIGVSNFN
  • EKCKDAGL

Post-translational modifications for AKR1C4 Gene

Other Protein References for AKR1C4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for AKR1C4 (Aldo-keto Reductase 1C4/AKR1C4)
  • Abcam antibodies for AKR1C4

Domains & Families for AKR1C4 Gene

Gene Families for AKR1C4 Gene

Suggested Antigen Peptide Sequences for AKR1C4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17516

UniProtKB/Swiss-Prot:

AK1C4_HUMAN :
  • Belongs to the aldo/keto reductase family.
Family:
  • Belongs to the aldo/keto reductase family.
genes like me logo Genes that share domains with AKR1C4: view

Function for AKR1C4 Gene

Molecular function for AKR1C4 Gene

GENATLAS Biochemistry:
aldo-keto reductase family 1,member C4 (3-alpha hydroxysteroid dehydrogenase,type I),with high affinity for dihydrotestosterone,chlordecone reductase,specifically expressed in liver,cytosolic,catalyzing detoxification of organochloride pesticids
UniProtKB/Swiss-Prot CatalyticActivity:
Chlordecone alcohol + NADP(+) = chlordecone + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.

Enzyme Numbers (IUBMB) for AKR1C4 Gene

Gene Ontology (GO) - Molecular Function for AKR1C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001758 retinal dehydrogenase activity IDA 21851338
GO:0004033 aldo-keto reductase (NADP) activity TAS --
GO:0009055 electron carrier activity TAS 8172617
GO:0015125 bile acid transmembrane transporter activity TAS 8172617
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with AKR1C4: view
genes like me logo Genes that share phenotypes with AKR1C4: view

Human Phenotype Ontology for AKR1C4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AKR1C4 Gene

Localization for AKR1C4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR1C4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKR1C4 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for AKR1C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,TAS 2187532
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with AKR1C4: view

Pathways & Interactions for AKR1C4 Gene

genes like me logo Genes that share pathways with AKR1C4: view

Interacting Proteins for AKR1C4 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000263126%0d%0a9606.ENSP00000229416%0d%0a9606.ENSP00000244217%0d%0a9606.ENSP00000166345%0d%0a9606.ENSP00000081029%0d%0a9606.ENSP00000261173%0d%0a
Selected Interacting proteins: ENSP00000263126 P17516-AK1C4_HUMAN for AKR1C4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for AKR1C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006699 bile acid biosynthetic process TAS --
GO:0008202 steroid metabolic process TAS 8274401
GO:0008209 androgen metabolic process TAS 7650035
GO:0015721 bile acid and bile salt transport TAS 8172617
genes like me logo Genes that share ontologies with AKR1C4: view

No data available for SIGNOR curated interactions for AKR1C4 Gene

Drugs & Compounds for AKR1C4 Gene

(19) Drugs for AKR1C4 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Exemestane Approved, Investigational Pharma Steroidal aromatase inhibitor,selective and irreversible 212
Androstanedione Experimental, Illicit Pharma 0
Etiocholanolone Experimental Pharma 0
Pyrocatechol Experimental Pharma 0
NADH Nutra Target 0

(36) Additional Compounds for AKR1C4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chlordecone
11b,21-Dihydroxy-3,20-oxo-5b-pregnan-18-al
  • 11beta,21-Dihydroxy-3,20-oxo-5beta-pregnan-18-al
  • Not Available
11b,21-Dihydroxy-5b-pregnane-3,20-dione
  • 11beta,21-Dihydroxy-5beta-pregnane-3,20-dione
  • 5beta-Pregnane-11beta,21-diol-3,20-dione
566-01-8
17a,21-Dihydroxy-5b-pregnane-3,11,20-trione
  • 17,21-Dihydroxy-5-beta-pregnane-3,11,20-trione
  • 17,21-Dihydroxy-5b-pregnane-3,11,20-trione
  • 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione
  • 4,5-b-Dihydrocortisone
  • 4,5-beta-Dihydrocortisone
68-54-2
21-Hydroxy-5b-pregnane-3,11,20-trione
  • 21-Hydroxy-5beta-pregnane-3,11,20-trione
10417-86-4
genes like me logo Genes that share compounds with AKR1C4: view

Transcripts for AKR1C4 Gene

mRNA/cDNA for AKR1C4 Gene

Unigene Clusters for AKR1C4 Gene

Aldo-keto reductase family 1, member C4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKR1C4 Gene

No ASD Table

Relevant External Links for AKR1C4 Gene

GeneLoc Exon Structure for
AKR1C4
ECgene alternative splicing isoforms for
AKR1C4

Expression for AKR1C4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AKR1C4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AKR1C4 Gene

This gene is overexpressed in Liver (x52.2).

Protein differential expression in normal tissues from HIPED for AKR1C4 Gene

This gene is overexpressed in Liver, secretome (36.6) and Liver (27.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AKR1C4 Gene



Protein tissue co-expression partners for AKR1C4 Gene

NURSA nuclear receptor signaling pathways regulating expression of AKR1C4 Gene:

AKR1C4

SOURCE GeneReport for Unigene cluster for AKR1C4 Gene:

Hs.567245

mRNA Expression by UniProt/SwissProt for AKR1C4 Gene:

P17516-AK1C4_HUMAN
Tissue specificity: Liver specific.
genes like me logo Genes that share expression patterns with AKR1C4: view

Primer Products

Orthologs for AKR1C4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AKR1C4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKR1C4 34 35
  • 98.66 (n)
mouse
(Mus musculus)
Mammalia Akr1c6 34 16 35
  • 78.53 (n)
Akr1c20 35
  • 73 (a)
ManyToMany
Akr1c21 35
  • 72 (a)
ManyToMany
Akr1cl 35
  • 71 (a)
ManyToMany
Akr1c18 35
  • 70 (a)
ManyToMany
Akr1c19 35
  • 70 (a)
ManyToMany
Akr1c14 35
  • 68 (a)
ManyToMany
Akr1c12 35
  • 67 (a)
ManyToMany
Akr1c13 35
  • 66 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Akr1c1 34
  • 77.61 (n)
cow
(Bos Taurus)
Mammalia 20ALPHA-HSD 35
  • 77 (a)
ManyToMany
-- 35
  • 76 (a)
ManyToMany
-- 35
  • 76 (a)
ManyToMany
BT.63212 35
  • 76 (a)
ManyToMany
-- 35
  • 75 (a)
ManyToMany
-- 35
  • 75 (a)
ManyToMany
-- 35
  • 73 (a)
ManyToMany
AKR1C4 35
  • 73 (a)
ManyToMany
-- 35
  • 72 (a)
ManyToMany
-- 35
  • 72 (a)
ManyToMany
-- 35
  • 70 (a)
ManyToMany
-- 35
  • 69 (a)
ManyToMany
-- 35
  • 69 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia akr1c4 34
  • 64.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10638 36
  • 43 (a)
CG12766 36
  • 43 (a)
BcDNA:GH10614 36
  • 41 (a)
CG9436 36
  • 41 (a)
CG2767 36
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea Y39G8B.1a 36
  • 40 (a)
C07D8.6 36
  • 38 (a)
T08H10.1 36
  • 37 (a)
ZC443.1 36
  • 35 (a)
F53F1.2 36
  • 34 (a)
Y39G8B.2 36
  • 34 (a)
F53F1.3 36
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G62420 34
  • 47.17 (n)
Species where no ortholog for AKR1C4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for AKR1C4 Gene

ENSEMBL:
Gene Tree for AKR1C4 (if available)
TreeFam:
Gene Tree for AKR1C4 (if available)

Paralogs for AKR1C4 Gene

Paralogs for AKR1C4 Gene

(11) SIMAP similar genes for AKR1C4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for AKR1C4 Gene

genes like me logo Genes that share paralogs with AKR1C4: view

Variants for AKR1C4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for AKR1C4 Gene

AK1C4_HUMAN-P17516
The allele with Cys-145/Val-311 shows a three- to five-fold decrease in catalytic efficiency for xenobiotic and steroidal substrates compared to the Ser-145/Leu-311 allele.

Sequence variations from dbSNP and Humsavar for AKR1C4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs398122815 other 5,200,075(+) GAAGC(G/T)AGCCA intron-variant
rs201441444 untested 5,205,843(+) AGTGC(G/T)TGGAG intron-variant
rs10458789 -- 5,216,318(+) aatta(C/T)ttttt intron-variant
rs10458795 -- 5,216,106(+) tactc(A/G)tggta intron-variant
rs10711188 -- 5,196,377(+) CCACT(-/A)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for AKR1C4 Gene

Variant ID Type Subtype PubMed ID
nsv5643 CNV deletion 18451855
nsv549886 CNV loss 21841781
nsv549883 CNV loss 21841781
nsv549881 CNV loss 21841781
nsv508566 CNV deletion 20534489
nsv1149325 CNV deletion 26484159
nsv1069010 CNV deletion 25765185
nsv1048081 CNV loss 25217958
nsv1039386 CNV gain 25217958
nsv1036566 CNV loss 25217958
esv4943 CNV loss 18987735
esv3622226 CNV loss 21293372
esv3622225 CNV loss 21293372
esv3622224 CNV gain 21293372
esv3622222 CNV gain 21293372
esv3622221 CNV loss 21293372
esv3545815 CNV deletion 23714750
esv2763913 CNV gain+loss 21179565
esv2731707 CNV deletion 23290073
esv2673923 CNV deletion 23128226
esv2665273 CNV deletion 23128226
esv23753 CNV loss 19812545
dgv350n106 CNV deletion 24896259

Variation tolerance for AKR1C4 Gene

Residual Variation Intolerance Score: 88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.68; 65.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKR1C4 Gene

Human Gene Mutation Database (HGMD)
AKR1C4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKR1C4

Disorders for AKR1C4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for AKR1C4 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
46xy sex reversal 8
  • 46xy sex reversal 8, modifier of
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

AK1C4_HUMAN
  • 46,XY sex reversal 8 (SRXY8) [MIM:614279]: A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. {ECO:0000269 PubMed:21802064}. Note=The gene represented in this entry may act as a disease modifier. A splicing mutation resulting in loss of AKR1C4 exon 2 has been found in affected individuals carrying a causative mutation in AKR1C2 (PubMed:21802064). These patients manifest a more severe disease phenotype than individuals only carrying mutations in AKR1C2. {ECO:0000269 PubMed:21802064}.

Relevant External Links for AKR1C4

Genetic Association Database (GAD)
AKR1C4
Human Genome Epidemiology (HuGE) Navigator
AKR1C4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKR1C4
genes like me logo Genes that share disorders with AKR1C4: view

No data available for Genatlas for AKR1C4 Gene

Publications for AKR1C4 Gene

  1. Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot study. (PMID: 15987428) Lord S.J. … Ursin G. (Breast Cancer Res. 2005) 3 22 46 64
  2. Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes. (PMID: 10672042) Nishizawa M. … Ito S. (Genes Cells 2000) 3 4 22 64
  3. Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization. (PMID: 7789999) Khanna M. … Cheng K.C. (Genomics 1995) 2 3 22 64
  4. Molecular cloning of two human liver 3 alpha- hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder. (PMID: 8172617) Deyashiki Y. … Hara A. (Biochem. J. 1994) 3 4 22 64
  5. Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase. (PMID: 2187532) Winters C.J. … Guzelian P.S. (Biochemistry 1990) 3 4 22 64

Products for AKR1C4 Gene

Sources for AKR1C4 Gene

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