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AKR1C2 Gene

protein-coding GIFtS: 56

GC10M005021

aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: DDH2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
3-alpha-HSD3 ^³
AKR1C-pseudo ^²
BABP ^¹, ²
DD ^¹, ²
DD-2 ^³
DD/BABP ^³
DD2 ^¹, ², ³, ⁵
DDH2 ^², ³, ⁵
EC 1.-.-.-,EC 1.3.1.20,EC 1.1.1.213 ^³
HAKRD ^¹, ², ⁵
HBAB ^²
MCDR2 ^¹, ²
OTTHUMP00000018995 ^²
OTTHUMP00000044759 ^²

Descriptions
Chlordecone reductase homolog HAKRD ^³
Dihydrodiol dehydrogenase 2 ^³
Dihydrodiol dehydrogenase/bile acid-binding protein ^³
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase ^², ³
Type III 3-alpha-hydroxysteroid dehydrogenase ^³
aldo-keto reductase family 1, member C2 ^²
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) ^²
chlordecone reductase homolog ^²
pseudo-chlordecone reductase ^²
type II dihydrodiol dehydrogenase ^²

External Ids
HGNC: 385¹
Entrez Gene: 1646²
UniProtKB: P52895³
Ensembl: ENSG00000151632⁷

Search outside databases for aliases for AKR1C2 gene

Previous GC identifers: GC10M005079 GC10M004991 GC10M004985

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AKR1C2:

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40

known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to

their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display

overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity,

and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence

identity with three other gene members and is clustered with those three genes at chromosome

10p15-p14. [provided by RefSeq]

UniProtKB/Swiss-Prot: AK1C2_HUMAN, P52895

Function: Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones

into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the

most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to

5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15-p14 Ensembl cytogenetic band: 10p15.1 HGNC cytogenetic band: 10p15-p14

AKR1C2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M005021: (about GC identifiers)

Start:	5,021,965 bp from pter
End:	5,050,207 bp from pter
Size:	28,243 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_077567.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AK1C2_HUMAN, P52895 (See protein sequence)

Recommended Name: Aldo-keto reductase family 1 member C2

Size: 323 amino acids; 36735 Da

Subcellular location: Cytoplasm (Potential)

PDB structures from and Proteopedia :

1IHI (3D)

1J96 (3D)

1XJB (3D)

2HDJ (3D)

2IPJ (3D)

Secondary accessions: A8K2N9 Q14133 Q5SR16 Q7M4N1 Q96A71

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001345.1 NP_995317.1

ENSEMBL proteins:

ENSP00000370020 ENSP00000327636 ENSP00000385221 ENSP00000370129

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AKR1C2)
	Human Recombinant Proteins from Abnova (AKR1C2)

OriGene Purified Recombinant Human Protein: AKR1C2

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

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Antibodies for AKR1C2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AKR1C2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (AKR1C2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AKR1C2)
	Novus Biologicals Antibodies for AKR1C2

Assays for AKR1C2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P52895

ProtoNet protein and cluster: P52895

1 Blocks protein family: IPB001395 Aldo/keto reductase

UniProtKB/Swiss-Prot: AK1C2_HUMAN, P52895

Similarity: Belongs to the aldo/keto reductase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AKR1C2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AKR1C2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001354

Applied Biosystems Silencer® siRNAs for AKR1C2

Sigma-Aldrich siRNA and siRNA Panels for AKR1C2

Sigma-Aldrich shRNA for AKR1C2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AKR1C2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001354
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001354
untagged cDNA clones in CMV expression vector (see all 2): NM_001354

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001354

UniProtKB/Swiss-Prot: AK1C2_HUMAN, P52895

Function: Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones

into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the

most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to

5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability

Catalytic activity: Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH

Catalytic activity: Androsterone + NAD(P)(+) = 5-alpha-androstane-3,17-dione + NAD(P)H

Enzyme regulation: Inhibited by hexestrol with an IC(50) of 2.8 uM, 1,10-phenanthroline with an

IC(50) of 2100 uM, 1,7-phenanthroline with an IC(50) of 1500 uM, flufenamic acid with an IC(50) of

0.9 uM, indomethacin with an IC(50) of 75 uM, ibuprofen with an IC(50) of 6.9 uM, lithocholic acid

with an IC(50) of 0.07 uM, ursodeoxycholic acid with an IC(50) of 0.08 uM and chenodeoxycholic

acid with an IC(50) of 0.13 uM

Biophysicochemical properties: Kinetic parameters: KM=260 uM for (s)-tetralol; KM=520 uM for

(s)-indan-1-ol; KM=5000 uM for benzene dihydrodiol; KM=1 uM for

5-beta-pregnane-3-alpha,20-alpha-diol; KM=208 uM for 9-alpha,11-beta-PGF2; KM=0.3 uM for

5-beta-androstane-3,17-dione; KM=79 uM for PGD2;

Enzyme Number (IUBMB): EC 1.-.-.-,EC

Genatlas biochemistry entry for AKR1C2:

aldo-keto reductase family 1,member C2 (3-alpha hydroxysteroid dehydrogenase,type III),mainly

expressed in liver,also in other tissues,with high affinity binding for bile acids,also catalyzing

detoxification of polycyclic aromatic hydrocarbons

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016491	oxidoreductase activity	IEA	--
GO:0032052	bile acid binding	IDA	8573067
GO:0047026	3-alpha-hydroxysteroid dehydrogenase (A-specific) activity	IEA	--
GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	IDA	8573067

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for AKR1C2 (Your Favorite Gene powered by Ingenuity)

TR/RXR Activation
Metabolism of Xenobiotics by Cytochrome P450

GeneDecks AKR1C2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for AKR1C2

5/16 Interacting proteins for AKR1C2 (ENSP00000370129³) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DHDH	ENSP00000221403³	STRING (score=.991)
CYP1A1	ENSP00000369050³	STRING (score=.923)
CYP1A2	ENSP00000342007³	STRING (score=.916)
EPHX1	ENSP00000355802³	STRING (score=.914)
CYP2B6	ENSP00000324648³	STRING (score=.899)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	IEA	--
GO:0006693	prostaglandin metabolic process	IDA	8573067
GO:0007586	digestion	IDA	8573067
GO:0008202	steroid metabolic process	IDA	8573067
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AKR1C2
10/18 Novoseek chemical compound relationships for AKR1C2 gene (see all 18 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
3alpha-hydroxysteroid	94.63	13	12416991 (1), 18252781 (1), 8546681 (1), 12539226 (1) (see all 12)
dihydroprogesterone	84.02	2	15494612 (1)
bile acid	79.42	4	10619355 (1), 8172617 (1), 15026176 (1)
chlordecone	79.02	5	7789999 (2), 10619355 (1), 8172617 (1)
hydroxysteroid	76.60	2	16455123 (2)
5alpha-dihydroprogesterone	74.05	3	11995921 (2)
androstenedione	73.04	1	14671194 (1)
nadp+	64.48	5	11513593 (2), 12810547 (1), 7948008 (1)
steroid	61.40	11	16455123 (2), 12604225 (1), 17662597 (1), 11514561 (1) (see all 8)
3alpha-hydroxy-5alpha-pregnan-20-one	56.35	1	11995921 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AKR1C2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AKR1C2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001354

Sigma-Aldrich siRNA and siRNA Panels for AKR1C2

Sigma-Aldrich shRNA for AKR1C2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001354 NM_205845

REFSEQ mRNAs for AKR1C2 gene (2 alternative transcripts):

NM_001354.4 NM_205845.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001354 NM_205845

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001354
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001354
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001354

Additional cDNA sequence:

AB209017.1 AK091128.1 AK290304.1 AK296419.1 AK296686.1 AK308385.1 BC007024.1 BC063574.1

M33376.1 U05598.1

24/30 DOTS entries (see all 30 ):

DT.92462965 DT.91810606 DT.100889730 DT.92462917 DT.97776113 DT.92027039 DT.100889725 DT.100889732

DT.100889726 DT.121225152 DT.97855879 DT.75180336 DT.91821287 DT.101985543 DT.437774 DT.121225295

DT.91931968 DT.100889715 DT.91653215 DT.92462948 DT.121225011 DT.121225128 DT.91835807 DT.100031708

24/261 AceView cDNA sequences (see all 261 ):

CB114571 CB133175 CB163887 NM_001354 AW264533 BC007024 BG289110 CB118359

BQ955939 BF725515 CB118742 BM793774 CB123515 CB115985 BM787660 F29946

BQ932644 CB118502 NM_205845 BE786673 BU158823 CB134192 BU153526 BQ182205

highest scoring ESTs for AKR1C2:

AB021654 AB031084 BQ421214 BQ932644 CB106556 CB121830 CB121831 CB136955 AA345096 AI114523

Unigene Cluster for AKR1C2:

Aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)

Hs.567256 [show with all ESTs]

Unigene Representative Sequence: AK091128

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for AKR1C2

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9	^	10
SP1:
SP2:																			-
SP3:									-
SP4:

About this scheme

ECgene alternative splicing isoforms for AKR1C2

4 Ensembl transcripts including schematic representations:

ENST00000380646 ENST00000331192 ENST00000407674 ENST00000380753

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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AKR1C2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AKR1C2

¹ / ² / ³

10 probe-sets matching AKR1C2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32805_at²^{, 3}	U95-A	3	1.00	0.49	1.00	1.00	U05861	0.20	0.50	0.38	1
209699_x_at²^{, 3}	U133-A	6	1.00	0.55	--	--	U05598	0.60	1.00	0.82	1
216594_x_at²^{, 3}	U133-A	5	1.00	0.41	--	--	S68290	0.60	0.78	0.69	1
211653_x_at²^{, 3}	U133-A	6	1.00	0.39	--	--	M33376	0.60	0.83	0.73	1
204151_x_at²^{, 3}	U133-A	4	0.82	0.33	--	--	NM_001353	0.40	0.67	0.55	1
209699_x_at²	U133Plus2	6	1.00	0.55	--	--	--	--	--	--	--
216594_x_at²	U133Plus2	5	1.00	0.41	--	--	--	--	--	--	--
211653_x_at²	U133Plus2	6	1.00	0.39	--	--	--	--	--	--	--
204151_x_at²	U133Plus2	4	0.82	0.33	--	--	--	--	--	--	--
1560098_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AKR1C2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.567256

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AKR1C2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	AKR1C4¹	--	aldo-keto reductase family 1, member C4 (chlordecone more	82.87(n) 77.71(a)	282138 NM_181027.2 NP_851370.1
rat (Rattus norvegicus)	Akr1c21¹	--	aldo-keto reductase family 1, member C21	77.57(n) 70.75(a)	291283 NM_001013057.1 NP_001013075.1
mouse (Mus musculus)	Akr1c21¹	--	aldo-keto reductase family 1, member C21	77.61(n) 73.37(a)	77337 NM_029901.2 NP_084177.2
fruit fly (Drosophila melanogaster)	CG6084³	68C15	aldehyde reductase	50(a) (best of 7)	--
worm (Caenorhabditis elegans)	Y39G8B.1a³	II(13970799-13972831)	--	41(a) (best of 10)	--

About this table Species with no ortholog for AKR1C2

ENSEMBL Gene Tree for AKR1C2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AKR1C2 gene

AKR1C1¹ ² tAKR² AKR1C3² AKR1CL1² AKR1C4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/329 NCBI SNPs in AKR1C2 are shown (see all 329 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 31)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs1937888^1,2	A,C,F,H	5050633(-)	`CAGCTG/ATAACA`	2	--	ng3¹		8		EU EA WA	836
--	rs1937865^1,2	A,F,H	5039637(-)	`TGTGAA/CTTTAA`	2	--	ut5¹ int¹		4		EU EA WA	418
--	rs1937886^1,2	A,C	5050780(-)	`gcaaaA/C/Ggaggt`	2	--	ng3¹		0	--	--	--	--
--	rs10904383^1,2	A,C	5021877(+)	`TCCAAC/TCCCGG`	2	--	ng5¹		0	--	--	--	--
--	rs1937884^1,2	A	5050887(-)	`GTCAAC/GGCTGC`	2	--	ng3¹		0	--	--	--	--
--	rs1937863^1,2	A,C,F,H,O	5041532(-)	`ACAAAT/CAGTGC`	2	--	int¹ tfbs³		15		EU EA WA NA	1398
--	rs12769178^1,2	A,C,F,H	5046717(+)	`atttaG/Cttttc`	2	--	int¹		4		EU EA WA	414
--	rs1937855^1,2	A,C,F,H	5044208(-)	`ACATGT/CAGAGA`	2	--	int¹		7		EU EA WA NA	550
--	rs1937860^1,2	A,C,F,H	5042471(-)	`tcaccA/Ggttca`	2	--	int¹		4		EU EA WA	416
--	rs2854494^1,2	A,C,F,H	5030003(-)	`ACACAC/TATTTC`	2	--	int¹		8		EU EA WA	836

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HapMap Linkage Disequilibrium images for AKR1C2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600450

6 Novoseek disease relationships for AKR1C2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
colon carcinoma	29.95	2	8573067 (1)
prostate cancer	29.56	12	17283174 (3), 12539226 (3), 18508192 (3), 12604227 (2) (see all 5)
obesity	15.00	1	17302881 (1)
nsclc	3.19	1	17266043 (1)
cancer	0.00	1	15929998 (1)
tumors	0.00	6	17283174 (3), 17203165 (1), 15212687 (1)

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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/96 PubMed articles for AKR1C2 gene (see all 96 ):

Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA. (PubMed id 9716498)^{1, 2, 3, 4} Shiraishi H.... Hara A. (1998)
Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate. (PubMed id 11513593)^{1, 3, 4} Jin Y....Lewis M. (2001)
Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes. (PubMed id 10672042)^{1, 3, 4} Nishizawa M.... Ito S. (2000)
Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells. (PubMed id 8573067)^{1, 3, 4} Hara A....Ishida N. (1996)
Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution. (PubMed id 11514561)^{1, 3, 4} Nahoum V.... Lin S.X. (2001)
Structure of a gene coding for human dihydrodiol dehydrogenase/bile acid-binding protein. (PubMed id 7959017)^{1, 3, 4} Qin K.-N.... Cheng K.-C. (1994)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Molecular cloning of human type 3 3 alpha-hydroxysteroid dehydrogenase that differs from 20 alpha-hydroxysteroid dehydrogenase by seven amino acids. (PubMed id 8920937)^{3, 4} Dufort I.... Luu-The V. (1996)
cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase. (PubMed id 8011662)^{3, 4} Ciaccio P.J. and Tew K.D. (1994)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1646	HGNC: 385	AceView: AKR1C2	Ensembl:ENSG00000151632	euGenes: HUgn1646
ECgene: AKR1C2	H-InvDB: AKR1C2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for AKR1C2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
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Products for AKR1C2:

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Antibodies for AKR1C2

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AKR1C2 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for AKR1C2

Summaries
for AKR1C2

Genomic Location
for AKR1C2

Proteins
for AKR1C2

Protein Domains/
Families
for AKR1C2

Gene Function
for AKR1C2

Pathways & Interactions
for AKR1C2

Drugs & Compounds
for AKR1C2

Transcripts
for AKR1C2

Expression
for AKR1C2

Orthologs
for AKR1C2

Paralogs
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SNPs/Variants
for AKR1C2

Disorders & Mutations
for AKR1C2

Medical News
for AKR1C2

Publications
for AKR1C2

Search for AKR1C2

Genome Databases showing AKR1C2

Other Databases showing AKR1C2

Specialized Databases showing AKR1C2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AKR1C2 (Gene Symbol)
3-alpha-HSD3
AKR1C-pseudo
BABP
DD
DD-2
DD/BABP
DD2
DDH2
EC 1.-.-.-,EC 1.3.1.20,EC 1.1.1.213
HAKRD
HBAB
MCDR2
OTTHUMP00000018995
OTTHUMP00000044759
Chlordecone reductase homolog HAKRD
Dihydrodiol dehydrogenase 2
Dihydrodiol dehydrogenase/bile acid-binding protein
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Type III 3-alpha-hydroxysteroid dehydrogenase
aldo-keto reductase family 1, member C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chlordecone reductase homolog
pseudo-chlordecone reductase
type II dihydrodiol dehydrogenase

AKR1C2 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor AKR1C2

Summariesfor AKR1C2

Genomic Locationfor AKR1C2

Proteinsfor AKR1C2

Protein Domains/Familiesfor AKR1C2

Gene Functionfor AKR1C2

Pathways & Interactionsfor AKR1C2

Drugs & Compoundsfor AKR1C2

Transcriptsfor AKR1C2

Expression for AKR1C2

Orthologsfor AKR1C2

Paralogsfor AKR1C2

SNPs/Variantsfor AKR1C2

Disorders & Mutationsfor AKR1C2

Medical Newsfor AKR1C2

Publicationsfor AKR1C2

Search for AKR1C2

Genome Databases showing AKR1C2

Other Databases showing AKR1C2

Specialized Databases showing AKR1C2

Licensable Technologiesfor AKR1C2

Servicesfor AKR1C2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AKR1C2

Summaries
for AKR1C2

Genomic Location
for AKR1C2

Proteins
for AKR1C2

Protein Domains/
Families
for AKR1C2

Gene Function
for AKR1C2

Pathways & Interactions
for AKR1C2

Drugs & Compounds
for AKR1C2

Transcripts
for AKR1C2

Expression
for AKR1C2

Orthologs
for AKR1C2

Paralogs
for AKR1C2

SNPs/Variants
for AKR1C2

Disorders & Mutations
for AKR1C2

Medical News
for AKR1C2

Publications
for AKR1C2

Licensable Technologies
for AKR1C2

Services
for AKR1C2