Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AKR1C2 Gene

protein-coding GIFtS: 61
GCID: GC10M005021

aldo-keto reductase family 1, member C2

(Previous names: aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase...)
(Previous symbol: DDH2)

Explore 23 diseases affiliated with
AKR1C2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Aldo-Keto Reductase Family 1, Member C2¹ ²		HBAB²
DD2¹ ² ³ ⁵		SRXY8²
DDH2¹ ² ³ ⁵		Aldo-Keto Reductase Family 1 Member C2²
HAKRD¹ ² ⁵		Dihydrodiol Dehydrogenase 2; Bile Acid Binding Protein; 3-Alpha Hydroxysteroid Dehydrogenase, Type III²
BABP¹ ²		Pseudo-Chlordecone Reductase²
DD¹ ²		Type II Dihydrodiol Dehydrogenase²
MCDR2¹ ²		EC 1.-.-.-³
Chlordecone Reductase Homolog HAKRD² ³		EC 1.1.1.213³
Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase² ³		EC 1.3.1.20³
3-Alpha-HSD3¹		Dihydrodiol Dehydrogenase 2³
DD-2² ³		Dihydrodiol Dehydrogenase/Bile Acid-Binding Protein³
DD/BABP² ³		Type III 3-Alpha-Hydroxysteroid Dehydrogenase³
Aldo-Keto Reductase Family 1, Member C2 (Dihydrodiol Dehydrogenase 2; Bile Acid Binding Protein; 3-Alpha Hydroxysteroid Dehydrogenase, Type III)¹		EC 1.1.1⁸
AKR1C-Pseudo¹

External Ids:	HGNC: 385¹	Entrez Gene: 1646²	Ensembl: ENSG00000151632⁷	OMIM: 600450⁵	UniProtKB: P52895³

Export aliases for AKR1C2 gene to outside databases

Previous GC identifers: GC10M005079 GC10M004991 GC10M004985

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AKR1C2:

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and

proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH

and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile

acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high

sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three

transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: AK1C2_HUMAN, P52895

Function: Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the

3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen

5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high

bile-binding ability

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008705.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for AKR1C2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AKR1C2 promoter sequence

Search SABiosciences Chromatin IP Primers for AKR1C2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKR1C2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15-p14 Ensembl cytogenetic band: 10p15.1 HGNC cytogenetic band: 10p15-p14

AKR1C2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKR1C2 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M005021: view genomic region (about GC identifiers)

Start:	5,029,967 bp from pter	End:	5,060,207 bp from pter
Size:	30,241 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AK1C2_HUMAN, P52895 (See protein sequence)

Recommended Name: Aldo-keto reductase family 1 member C2

Size: 323 amino acids; 36735 Da

Subcellular location: Cytoplasm (Potential)

5 PDB 3D structures from and Proteopedia for AKR1C2:

1IHI (3D)

1J96 (3D)

1XJB (3D)

2HDJ (3D)

2IPJ (3D)

Secondary accessions: A8K2N9 B4DKR9 Q14133 Q5SR16 Q7M4N1 Q96A71

Alternative splicing: 2 isoforms: P52895-1 P52895-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AKR1C2: NX_P52895

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P52895

2 DME Specific Peptides for AKR1C2 (P52895)

EKCKDAGL

KSIGVSNFN

AKR1C2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001128713.1 NP_001345.1 NP_995317.1

ENSEMBL proteins:

ENSP00000370129 ENSP00000392694 ENSP00000385221 ENSP00000408440

Human Recombinant Protein Products for AKR1C2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): AKR1C2 OriGene Protein Over-expression Lysate (see all 3): AKR1C2 OriGene Custom Protein Services for AKR1C2
	GenScript Custom Purified and Recombinant Proteins Services for AKR1C2
	Novus Biologicals AKR1C2 Proteins Novus Biologicals AKR1C2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for AKR1C2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

AKR1C2 for ontologies About GeneDecksing

AKR1C2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for AKR1C2
	GenScript Superior Antibodies for AKR1C2
	Novus Biologicals AKR1C2 Antibodies
	Abcam antibodies for AKR1C2
	Uscn Antibodies for AKR1C2
	Search ThermoFisher Antibodies for AKR1C2

Assay Products for AKR1C2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for AKR1C2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for AKR1C2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AKR1C2 for domains About GeneDecksing

4 InterPro domains/families:

IPR001395 Aldo/ket_red

IPR018170 Aldo/ket_reductase_CS

IPR020471 Aldo/keto_reductase_subgr

IPR023210 NADP_OxRdtase_dom

Graphical View of Domain Structure for InterPro Entry P52895

ProtoNet protein and cluster: P52895

1 Blocks protein family: IPB001395 Aldo/keto reductase

UniProtKB/Swiss-Prot: AK1C2_HUMAN, P52895

Similarity: Belongs to the aldo/keto reductase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: AK1C2_HUMAN, P52895

Function: Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the

3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen

5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high

bile-binding ability

Catalytic activity: Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH

Catalytic activity: A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H

Enzyme regulation: Inhibited by hexestrol with an IC(50) of 2.8 uM, 1,10-phenanthroline with an IC(50) of 2100 uM,

1,7-phenanthroline with an IC(50) of 1500 uM, flufenamic acid with an IC(50) of 0.9 uM, indomethacin with an IC(50) of

75 uM, ibuprofen with an IC(50) of 6.9 uM, lithocholic acid with an IC(50) of 0.07 uM, ursodeoxycholic acid with an

IC(50) of 0.08 uM and chenodeoxycholic acid with an IC(50) of 0.13 uM

Biophysicochemical properties: Kinetic parameters: KM=260 uM for (s)-tetralol; KM=520 uM for (s)-indan-1-ol; KM=5000 uM

for benzene dihydrodiol; KM=1 uM for 5-beta-pregnane-3-alpha,20-alpha-diol; KM=208 uM for 9-alpha,11-beta-PGF2; KM=0.3

uM for 5-beta-androstane-3,17-dione; KM=79 uM for PGD2;

Genatlas biochemistry entry for AKR1C2:

aldo-keto reductase family 1,member C2 (3-alpha hydroxysteroid dehydrogenase,type III),mainly expressed in liver,also

in other tissues,with high affinity binding for bile acids,also catalyzing detoxification of polycyclic aromatic

hydrocarbons

Enzyme Numbers (IUBMB): EC 1.3.1.20¹ EC 1.1.1² EC 1.1.1.213¹ EC 1.-.-.-¹

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	IDA	--
GO:0004958	prostaglandin F receptor activity	IDA	18508192
GO:0016491	oxidoreductase activity	--	--
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA	--
GO:0018636	phenanthrene 9,10-monooxygenase activity	IDA	--

AKR1C2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for AKR1C2:

Increased cell number in S and

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for AKR1C2

miRNA Products:		OriGene 3'-UTR Clone (see all 3): AKR1C2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKR1C2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AKR1C2
		SwitchGear 3'UTR luciferase reporter plasmid: AKR1C2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKR1C2 (see all 4) OriGene shRNA RFP: AKR1C2 OriGene siRNA: AKR1C2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKR1C2
		Sirion Biotech Custom design and validation of potent shRNA sequences against AKR1C2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for AKR1C2
			Sirion Biotech Customized adenovirus for overexpression of AKR1C2 Sirion Biotech Customized adenovirus for potent knockdown of AKR1C2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKR1C2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKR1C2 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): AKR1C2 (NM_001135241)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKR1C2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKR1C2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for AKR1C2
		Search LifeMap BioReagents cell lines for AKR1C2
		Sirion Biotech Customized stable knockdown cell line services for AKR1C2 Sirion Biotech Customized inducible knockdown cell line services for AKR1C2 Sirion Biotech Customized stable overexpressing cell line services for AKR1C2 Sirion Biotech Customized inducible overexpressing cell line services for AKR1C2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKR1C2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Naphthalene metabolism

	Naphthalene metabolism	1.00			Benzo(a)pyrene metabolism	0.32
	Naphthalene metabolism	1.00

Steroid hormone biosynthesis

Steroid hormone biosynthesis

1.00

Drug metabolism - cytochrome P450

Metabolism of xenobiotics by cytochrome P450

0.73

Biological oxidations

metapathway biotransformation

0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for AKR1C2

Naphthalene metabolism

1 GeneGo (Thomson Reuters) Pathway for AKR1C2

Naphthalene metabolism

2 BioSystems Pathways for AKR1C2

	Benzo(a)pyrene metabolism
	metapathway biotransformation

2 Kegg Pathways (Kegg details for AKR1C2):

	Steroid hormone biosynthesis
	Metabolism of xenobiotics by cytochrome P450

AKR1C2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for AKR1C2

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for AKR1C2 (ENSP00000370129⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COMMD8	ENSP00000370984⁴	STRING: ENSP00000370984
MAPK3	ENSP00000263025⁴	STRING: ENSP00000263025

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006693	prostaglandin metabolic process	IDA	8573067
GO:0007186	G-protein coupled receptor signaling pathway	IDA	18508192
GO:0007586	digestion	IDA	8573067
GO:0008202	steroid metabolic process	IDA	8573067
GO:0008284	positive regulation of cell proliferation	IDA	18508192

AKR1C2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

AKR1C2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AKR1C2

10/12 HMDB Compounds for AKR1C2 (see all 12) About this table

Compound	Synonyms	CAS #	PubMed Ids
Androstanedione	5a-Androsta-3,17-dione (see all 11)	846-46-8	--
Androsterone	(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one (see all 28)	53-41-8	--
Chenodeoxycholic acid	(+)-chenodeoxycholate (see all 13)	474-25-9	--
Ibuprofen	alpha-(4-Isobutylphenyl)propionate (see all 9)	15687-27-1	--
Lithocholic acid	(3a,5b)-3-hydroxy-cholan-24-oate (see all 5)	434-13-9	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
NADH	1,4-Dihydronicotinamide adenine dinucleotide (see all 17)	58-68-4	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Pyrocatechol	1,2-Dihydroxybenzene (see all 20)	120-80-9	--

4 DrugBank Compounds for AKR1C2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
NADH	beta-DPNH (see all 18)	606-68-8	target	--	12810547 17139284 17016423 12416991
Ursodeoxycholic acid	(3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid (see all 18)	128-13-2	target	inducer	17139284 17016423 19747134
2'-Monophosphoadenosine 5'-Diphosphoribose	--	--	target	--	17139284 17016423
(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE	--	--	target	--	10592235

10/25 Novoseek chemical compound relationships for AKR1C2 gene (see all 25) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
3alpha-hydroxysteroid	94.4	14	12416991 (1), 18252781 (1), 8546681 (1), 12539226 (1) (see all 13)
5alpha-androstane-3alpha,17beta-diol	91.2	9	18252781 (1), 12539226 (1), 12810547 (1), 12604227 (1) (see all 7)
dihydroprogesterone	83.1	2	15494612 (1)
dihydrotestosterone	80.1	39	17283174 (6), 12810547 (4), 12604227 (4), 19258517 (3) (see all 12)
chlordecone	77.9	5	7789999 (2), 10619355 (1), 8172617 (1)
bile acid	77.6	4	10619355 (1), 8172617 (1), 15026176 (1)
hydroxysteroid	75.3	2	16455123 (2)
5alpha-dihydroprogesterone	72.7	3	11995921 (2)
androstenedione	71.6	1	14671194 (1)
testosterone	63.3	14	17283174 (3), 18252781 (1), 12810547 (1), 20056642 (1) (see all 10)

Search CenterWatch for drugs/clinical trials and news about AKR1C2 / AK1C2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AKR1C2 gene (3 alternative transcripts):

NM_001135241.2 NM_001354.5 NM_205845.2

Unigene Cluster for AKR1C2:

Aldo-keto reductase family 1, member C2

Hs.567256 [show with all ESTs]

Unigene Representative Sequence: NM_001354

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000380753(uc009xhy.3 uc001ihs.3 uc001iht.3) ENST00000460124(uc010qao.2)

ENST00000421196 ENST00000407674 ENST00000455190

miRNA Products:		OriGene 3'-UTR Clone (see all 3): AKR1C2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKR1C2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AKR1C2
		SwitchGear 3'UTR luciferase reporter plasmid: AKR1C2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKR1C2 (see all 4) OriGene shRNA RFP: AKR1C2 OriGene siRNA: AKR1C2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKR1C2
		Sirion Biotech Custom design and validation of potent shRNA sequences against AKR1C2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKR1C2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKR1C2 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): AKR1C2 (NM_001135241)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKR1C2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKR1C2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKR1C2 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat AKR1C2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKR1C2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKR1C2

Additional cDNA sequence:

AB209017.1 AK290304.1 AK296419.1 AK296686.1 AK308385.1 BC007024.1 BC063574.1 M33376.1

U05598.1

24/28 DOTS entries (see all 28):

DT.92462965 DT.91810606 DT.100889730 DT.92462917 DT.97776113 DT.92027039 DT.100889726 DT.100889732

DT.121225152 DT.97855879 DT.40217695 DT.75180336 DT.429915 DT.100889725 DT.437774 DT.91931968

DT.92462948 DT.101985543 DT.121225011 DT.121225128 DT.91835807 DT.100031708 DT.100889727 DT.121225233

24/261 AceView cDNA sequences (see all 261):

CA308355 AW873138 AU280039 F30876 CB122734 CB134192 BE439903 CB157186

CB115985 BG289110 CD368175 BU617644 BQ932644 BM787660 BE786673 CA431705

CB118635 CA309808 BC007024 BQ182205 NM_205845 CB118669 AB031084 BM975692

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for AKR1C2 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9	^	10
SP1:
SP2:																			-
SP3:									-
SP4:

ECgene alternative splicing isoforms for AKR1C2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AKR1C2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

AKR1C2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+BMP4-induced MEL2 cells (HyStem+BMP4 inductio...)

Bone

HyStem+BMP4-induced E15 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See AKR1C2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AKR1C2

SOURCE GeneReport for Unigene cluster: Hs.567256

UniProtKB/Swiss-Prot: AK1C2_HUMAN, P52895

Tissue specificity: Expressed in fetal testes. Expressed in fetal and adult adrenal glands

SABiosciences Custom PCR Arrays for AKR1C2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKR1C2 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat AKR1C2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKR1C2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKR1C2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKR1C2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for AKR1C2 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	--	--	40(a)	possible ortholog	AAWZ02039178(2232-9058)
African clawed frog (Xenopus laevis)	Amphibia	MGC53504²	similar to hydroxysteroid (17-beta) dehydrogenase 5	75.62(n)		BC044678.1
zebrafish (Danio rerio)	Actinopterygii	zgc:56622⁶	zgc:56622	43(a)	possible ortholog	18(12660381-12669534)
fruit fly (Drosophila melanogaster)	Insecta	CG6084³	aldehyde reductase	50(a) (best of 7)		68C15 --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G59950¹	NAD(P)-linked oxidoreductase-like protein	51.48(n) 44.44(a)		842289 NM_104687.1 NP_176203.1
rice (Oryza sativa)	Liliopsida	Os04g0447700¹	hypothetical protein	47.97(n) 40.96(a)		4335976 NM_001059453.1 NP_001052918.1

ENSEMBL Gene Tree for AKR1C2 (if available)
TreeFam Gene Tree for AKR1C2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AKR1C2 gene

AKR1C1¹ ² AKR1C3² AKR1CL1² AKR1B10² AKR1A1² AKR1E2² AKR1C4² AKR1B15²

AKR1B1² AKR1D1²

11 SIMAP similar genes for AKR1C2 using alignment to 3 protein entries: AK1C2_HUMAN (see all proteins):

AKR1C3 AKR1C4 AKR1C1 AKR1CL1 AKR1D1 AKR1B1

AKR1B15 AKR1B10 AKR1A1 AKR1E2 LOC402299

AKR1C2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201709962^1,2		--	5029665(+)	`GATTT-/CTTTTT`	2	--	ds500¹		0	--	--	--	--
rs68057779^1,2	C	--	5030148(+)	`TTACAC/TCTCAA`	2	--	ut3¹		2		NA	4
rs190579450^1,2		--	5030154(+)	`CTCAAC/GTGTTC`	2	--	ut3¹		0	--	--	--	--
rs11252866^1,2	C,F,H	--	5030267(+)	`GCAGCC/TGTACT`	2	--	ut3¹ ese³		17		NS EA NA WA	2326
rs45615836^1,2	F	--	5030355(+)	`AAAGTC/TTGCTT`	2	--	ut3¹		1		WA	118
rs11252867^1,2	C,F,H	--	5030368(+)	`GCGTTA/TCACAC`	2	--	ut3¹ ese³		25		NS EA NA WA	2812
rs7092939^1,2	C	--	5030450(+)	`AATTAC/TCATTC`	2	--	ut3¹		1		WA	2
rs45460998^1,2		--	5030479(+)	`AGGTAC/GAACAG`	2	--	ut3¹		0	--	--	--	--
rs4526684^1,2	A	--	5030526(-)	`TCACAC/TTTAGC`	2	--	ut3¹ ese³		0	--	--	--	--
rs4584482^1,2	C,H	--	5030533(-)	`TGGACA/GTNNNN`	2	--	ut3¹		8		NS EA NA WA	656

HapMap Linkage Disequilibrium report for AKR1C2 (5029967 - 5060207 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for AKR1C2
1 Inversion: 59908
Human Gene Mutation Database (HGMD): AKR1C2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKR1C2

DNA2.0 Custom Variant and Variant Library Synthesis for AKR1C2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AKR1C2 for disorders About GeneDecksing

OMIM gene information: 600450 OMIM disorders: --

UniProtKB/Swiss-Prot: AK1C2_HUMAN, P52895

Defects in AKR1C2 are a cause of 46,XY sex reversal type 8 (SRXY8) [MIM:614279]. A disorder of sex

development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females

20/23 diseases for AKR1C2 (see all 23): About MalaCards

obesity, hyperphagia, and developmental delay xy sex reversal sex reversal disorders of sex development

barrett's esophagus alcoholism ovarian endometriosis squamous cell carcinoma

obesity endometriosis hepatitis b prostate cancer

breast cancer liver cancer ovarian carcinoma carcinoma

breast carcinoma lung cancer prostatitis hepatitis

1 disease from the University of Copenhagen DISEASES database for AKR1C2:

Hepatitis B

7 Novoseek disease relationships for AKR1C2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	29.9	12	17283174 (3), 12539226 (3), 18508192 (3), 12604227 (2) (see all 5)
colon carcinoma	27.4	2	8573067 (1)
breast cancer	13.3	3	19846565 (2)
obesity	10.7	1	17302881 (1)
nsclc	0	1	17266043 (1)
tumors	0	6	17283174 (3), 17203165 (1), 15212687 (1)
cancer	0	1	15929998 (1)

Human Genome Epidemiology (HuGE) Navigator: AKR1C2 (5 documents)

Export disorders for AKR1C2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for AKR1C2 gene, integrated from 9 sources (see all 125):
(articles sorted by number of sources associating them with AKR1C2)

Utopia: connect your pdf to the dynamic
world of online information

Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA. (PubMed id 9716498)^{1, 2, 3, 9} Shiraishi H.... Hara A. (1998)
Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells. (PubMed id 12810547)^{1, 7, 9} Rizner T.L....Penning T.M. (2003)
Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate. (PubMed id 11513593)^{1, 2, 9} Jin Y....Lewis M. (2001)
Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes. (PubMed id 10672042)^{1, 2, 9} Nishizawa M.... Ito S. (2000)
Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells. (PubMed id 8573067)^{1, 2, 9} Hara A....Ishida N. (1996)
Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution. (PubMed id 11514561)^{1, 2, 9} Nahoum V.... Lin S.X. (2001)
Structure of a gene coding for human dihydrodiol dehydrogenase/bile acid-binding protein. (PubMed id 7959017)^{1, 2, 9} Qin K.-N.... Cheng K.-C. (1994)
Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2). (PubMed id 12416991)^{1, 7, 9} Trauger J.W....LoGrasso P.V. (2002)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1646	HGNC: 385	AceView: AKR1C2	Ensembl:ENSG00000151632	euGenes: HUgn1646
ECgene: AKR1C2	Kegg: 1646	H-InvDB: AKR1C2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for AKR1C2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for AKR1C2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for AKR1C2 gene:
Search GeneIP for patents involving AKR1C2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for AKR1C2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKR1C2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKR1C2
	OriGene Protein Over-expression Lysate for AKR1C2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for AKR1C2		OriGene 3'-UTR Clone for AKR1C2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKR1C2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKR1C2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for AKR1C2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for AKR1C2		OriGene Custom Protein Services for AKR1C2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AKR1C2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKR1C2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKR1C2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKR1C2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKR1C2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKR1C2

	GenScript Custom Purified and Recombinant Proteins Services for AKR1C2		GenScript cDNA clones with any tag delivered in your preferred vector for AKR1C2
	GenScript Custom Assay Services for AKR1C2		GenScript Superior Antibodies for AKR1C2
	GenScript Custom overexpressing Cell Line Services for AKR1C2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Search Regulatory tfbs for AKR1C2
	Search Chromatin IP Primers for AKR1C2
	RT² qPCR Primer Assay in human, mouse / rat AKR1C2
	GNC Network for AKR1C2
	SABiosciences Custom PCR Arrays for AKR1C2

Search Tocris compounds for AKR1C2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	AKR1C2 antibodies
	AKR1C2 proteins
	AKR1C2 lysates

	Antibodies for AKR1C2
	See all of Abcam's Antibodies, Kits and Proteins for AKR1C2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

AKR1C2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for AKR1C2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKR1C2

	SwitchGear 3'UTR luciferase reporter plasmids for AKR1C2
	SwitchGear Promoter luciferase reporter plasmids for AKR1C2

Search ThermoFisher Antibodies for AKR1C2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKR1C2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for AKR1C2

Sirion Biotech Customized:

	stable knockdown cell line services for AKR1C2
	inducible knockdown cell line services for AKR1C2
	design and validation of potent shRNA sequences against AKR1C2
	adenovirus for potent knockdown of AKR1C2
	adenovirus for overexpression of AKR1C2
	stable overexpressing cell line services for AKR1C2
	inducible overexpressing cell line services for AKR1C2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes AKR1C2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

AKR1C2 Gene

aldo-keto reductase family 1, member C2

Aliases
for AKR1C2 gene

Summaries
for AKR1C2 gene

Genomic Views
for AKR1C2 gene

Proteins
for AKR1C2 gene

Protein Domains /
Families
for AKR1C2 gene

Function
for AKR1C2 gene

Pathways & Interactions
for AKR1C2 gene

Drugs & Compounds
for AKR1C2 gene

Transcripts
for AKR1C2 gene

Expression
for AKR1C2 gene

Orthologs
for AKR1C2 gene

Paralogs
for AKR1C2 gene

Genomic Variants
for AKR1C2 gene

Disorders / Diseases
for AKR1C2 gene

Publications
for AKR1C2 gene

External Searches for AKR1C2 gene

Genome Databases showing AKR1C2 gene

Other Databases showing AKR1C2 gene

Specialized Databases showing AKR1C2 gene

Intellectual Property
for AKR1C2 gene

Products
for AKR1C2 gene

View Random Gene

AKR1C2 (Gene Symbol)
Aldo-Keto Reductase Family 1, Member C2
DD2
DDH2
HAKRD
BABP
DD
MCDR2
Chlordecone Reductase Homolog HAKRD
Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase
3-Alpha-HSD3
DD-2
DD/BABP
Aldo-Keto Reductase Family 1, Member C2 (Dihydrodiol Dehydrogenase 2; Bile Acid Binding Protein; 3-Alpha Hydroxysteroid Dehydrogenase, Type III)
AKR1C-Pseudo
HBAB
SRXY8
Aldo-Keto Reductase Family 1 Member C2
Dihydrodiol Dehydrogenase 2; Bile Acid Binding Protein; 3-Alpha Hydroxysteroid Dehydrogenase, Type III
Pseudo-Chlordecone Reductase
Type II Dihydrodiol Dehydrogenase
EC 1.-.-.-
EC 1.1.1.213
EC 1.3.1.20
Dihydrodiol Dehydrogenase 2
Dihydrodiol Dehydrogenase/Bile Acid-Binding Protein
Type III 3-Alpha-Hydroxysteroid Dehydrogenase
EC 1.1.1

Advanced Search

Export list of displayed genes

AKR1C2 Gene

aldo-keto reductase family 1, member C2

Aliasesfor AKR1C2 gene

Summariesfor AKR1C2 gene

Genomic Viewsfor AKR1C2 gene

Proteinsfor AKR1C2 gene

Protein Domains /Familiesfor AKR1C2 gene

Functionfor AKR1C2 gene

Pathways & Interactionsfor AKR1C2 gene

Drugs & Compoundsfor AKR1C2 gene

Transcriptsfor AKR1C2 gene

Expression for AKR1C2 gene

Orthologsfor AKR1C2 gene

Paralogsfor AKR1C2 gene

Genomic Variantsfor AKR1C2 gene

Disorders / Diseasesfor AKR1C2 gene

Publicationsfor AKR1C2 gene

External Searches for AKR1C2 gene

Genome Databases showing AKR1C2 gene

Other Databases showing AKR1C2 gene

Specialized Databases showing AKR1C2 gene

Intellectual Propertyfor AKR1C2 gene

Productsfor AKR1C2 gene

View Random Gene

Aliases
for AKR1C2 gene

Summaries
for AKR1C2 gene

Genomic Views
for AKR1C2 gene

Proteins
for AKR1C2 gene

Protein Domains /
Families
for AKR1C2 gene

Function
for AKR1C2 gene

Pathways & Interactions
for AKR1C2 gene

Drugs & Compounds
for AKR1C2 gene

Transcripts
for AKR1C2 gene

Expression
for AKR1C2 gene

Orthologs
for AKR1C2 gene

Paralogs
for AKR1C2 gene

Genomic Variants
for AKR1C2 gene

Disorders / Diseases
for AKR1C2 gene

Publications
for AKR1C2 gene

Intellectual Property
for AKR1C2 gene

Products
for AKR1C2 gene