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AKR1C1 Gene

protein-coding GIFtS: 62

GC10P004995

aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: DDH1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
2-ALPHA-HSD ^²
20-ALPHA-HSD ^²
20-alpha-HSD ^³
C9 ^²
DD1 ^¹, ², ⁵
DD1/DD2 ^³
DDH ^¹, ², ³
DDH1 ^², ³, ⁵
EC 1.1.1.-,EC 1.1.1.149,EC 1.3.1.20,EC 1.1.1.112 ^³
H-37 ^²
HAKRC ^¹, ², ⁵
HBAB ^³
MBAB ^¹, ²
MGC8954 ^²
OTTHUMP00000018992 ^²

Descriptions
20 alpha-hydroxysteroid dehydrogenase ^²
20-alpha-hydroxysteroid dehydrogenase ^³
Chlordecone reductase homolog HAKRC ^³
Dihydrodiol dehydrogenase 1/2 ^³
High-affinity hepatic bile acid-binding protein ^³
Indanol dehydrogenase ^³
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase ^², ³
aldo-keto reductase C ^²
aldo-keto reductase family 1, member C1 ^²
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) ^²
chlordecone reductase homolog ^²
dihydrodiol dehydrogenase 1 ^²
dihydrodiol dehydrogenase isoform DD1 ^²
hepatic dihydrodiol dehydrogenase ^²
type II 3-alpha-hydroxysteroid dehydrogenase ^²

External Ids
HGNC: 384¹
Entrez Gene: 1645²
UniProtKB: Q04828³
Ensembl: ENSG00000187134⁷

Search outside databases for aliases for AKR1C1 gene

Previous GC identifers: GC10P005053 GC10P004959

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AKR1C1:

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40

known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to

their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display

overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone

to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with

three other gene members and is clustered with those three genes at chromosome 10p15-p14.

[provided by RefSeq]

UniProtKB/Swiss-Prot: AK1C1_HUMAN, Q04828

Function: Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone

(20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a

role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May

play a role in myelin formation

Gene Wiki entry for AKR1C1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AKR1C1 gene

Entrez Gene cytogenetic band: 10p15-p14 Ensembl cytogenetic band: 10p15.1 HGNC cytogenetic band: 10p15-p14

AKR1C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P004995: (about GC identifiers)

Start:	4,995,454 bp from pter
End:	5,010,445 bp from pter
Size:	14,992 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_077567.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AK1C1_HUMAN, Q04828 (See protein sequence)

Recommended Name: Aldo-keto reductase family 1 member C1

Size: 323 amino acids; 36788 Da

Subunit: Monomer

Subcellular location: Cytoplasm

PDB structure from and Proteopedia :

1MRQ (3D)

3C3U (3D)

Secondary accessions: P52896 Q5SR15 Q7M4N2 Q9UCX2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001344.2

ENSEMBL proteins:

ENSP00000370240 ENSP00000370254

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AKR1C1)
	Human Recombinant Proteins from Abnova (AKR1C1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	IDA	8486699

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Antibodies for AKR1C1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AKR1C1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (AKR1C1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AKR1C1)
	Novus Biologicals Antibodies for AKR1C1

Assays for AKR1C1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q04828

ProtoNet protein and cluster: Q04828

1 Blocks protein family: IPB001395 Aldo/keto reductase

UniProtKB/Swiss-Prot: AK1C1_HUMAN, Q04828

Similarity: Belongs to the aldo/keto reductase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AKR1C1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AKR1C1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001353

Applied Biosystems Silencer® siRNAs for AKR1C1

Sigma-Aldrich siRNA and siRNA Panels for AKR1C1

Sigma-Aldrich shRNA for AKR1C1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AKR1C1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001353
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001353
untagged cDNA clone in CMV expression vector: NM_001353

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001353

UniProtKB/Swiss-Prot: AK1C1_HUMAN, Q04828

Function: Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone

(20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a

role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May

play a role in myelin formation

Catalytic activity: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) =

17-alpha-hydroxyprogesterone + NAD(P)H

Catalytic activity: Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH

Catalytic activity: Indan-1-ol + NAD(P)(+) = indanone + NAD(P)H

Enzyme regulation: Inhibited by hexestrol with an IC(50) of 9.5 uM, 1,10-phenanthroline with an

IC(50) of 55 uM, 1,7-phenanthroline with an IC(50) of 72 uM, flufenamic acid with an IC(50) of 6.0

uM, indomethacin with an IC(50) of 140 uM, ibuprofen with an IC(50) of 950 uM, lithocholic acid

with an IC(50) of 25 uM, ursodeoxycholic acid with an IC(50) of 340 uM and chenodeoxycholic acid

with an IC(50) of 570 uM

Biophysicochemical properties: Kinetic parameters: KM=5 uM for (s)-tetralol; KM=38 uM for

(s)-indan-1-ol; KM=580 uM for benzene dihydrodiol; KM=3 uM for

5-beta-pregnane-3-alpha,20-alpha-diol; KM=3 uM for 5-beta-pregnan-20-alpha-ol-3-one; KM=12 uM for

4-pregnen-20-alpha-ol-3-one; KM=133 uM for 9-alpha,11-beta-PGF2; KM=2 uM for

5-beta-pregnan-3-alpha-ol-20-one; KM=1 uM for 5-beta-androstane-3,17-dione; KM=12 uM for PGD2;

KM=0.6 uM for 20-alpha-hydroxyprogesterone (with NADH);

Enzyme Number (IUBMB): EC 1.1.1.-,EC

Genatlas biochemistry entry for AKR1C1:

aldo-keto reductase family 1,expressed only in kidney,liver,testis,cytosolic,member C1 (20-alpha

(3-alpha)-hydroxysteroid dehydrogenase),with high affinity binding for bile acids,also catalyzing

detoxification of polycyclic aromatic hydrocarbons

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004033	aldo-keto reductase activity	TAS	7789999
GO:0016491	oxidoreductase activity	IEA	--
GO:0032052	bile acid binding	IDA	8486699
GO:0047006	20-alpha-hydroxysteroid dehydrogenase activity	IEA	--
GO:0047042	3-alpha-hydroxysteroid dehydrogenase (B-specific) activity	IDA	8486699

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for AKR1C1 (Your Favorite Gene powered by Ingenuity)

Bile Acid Biosynthesis
C21-Steroid Hormone Metabolism
Metabolism of Xenobiotics by Cytochrome P450
TR/RXR Activation
Androgen and Estrogen Metabolism

GeneDecks AKR1C1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for AKR1C1

5/17 Interacting proteins for AKR1C1 (ENSP00000370254³) via UniProtKB, MINT, and/or STRING (see all 17 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DHDH	ENSP00000221403³	STRING (score=.991)
CYP1A1	ENSP00000369050³	STRING (score=.956)
EPHX1	ENSP00000355802³	STRING (score=.92)
CYP1A2	ENSP00000342007³	STRING (score=.909)
CYP2B6	ENSP00000324648³	STRING (score=.899)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	NAS	8486699
GO:0007586	digestion	IDA	8486699
GO:0008206	bile acid metabolic process	IDA	8486699
GO:0015721	bile acid and bile salt transport	TAS	8486699
GO:0030299	cholesterol absorption	TAS	8486699

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AKR1C1
10/24 Novoseek chemical compound relationships for AKR1C1 gene (see all 24 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
1-acenaphthenol	93.83	3	10510318 (1), 19007763 (1)
dihydroprogesterone	93.61	12	18984031 (2), 8446108 (1), 16720716 (1), 14967952 (1) (see all 10)
3alpha-hydroxysteroid	91.92	7	7766669 (1), 18574251 (1), 8486699 (1), 8132567 (1) (see all 7)
hydroxysteroid	77.14	5	16455123 (2), 19007763 (1), 17170221 (1)
chlordecone	76.53	4	10510318 (1), 8446108 (1), 8486699 (1)
3alpha-hydroxy-5alpha-pregnan-20-one	72.83	1	11995921 (1)
5alpha-dihydroprogesterone	71.23	3	11995921 (2)
17beta-hydroxysteroid	69.62	1	11013348 (1)
progesterone	66.58	44	16338060 (4), 12733716 (3), 16720716 (2), 12507272 (2) (see all 25)
nadp+	64.56	1	18620380 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AKR1C1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AKR1C1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001353

Sigma-Aldrich siRNA and siRNA Panels for AKR1C1

Sigma-Aldrich shRNA for AKR1C1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001353

REFSEQ mRNAs for AKR1C1 gene:

NM_001353.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001353

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001353
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001353
                                 untagged cDNA clone in CMV expression vector: NM_001353

Additional cDNA sequence:

AB021654.1 AB031083.1 AB031084.1 AK226067.1 AK303435.1 AK310658.1 BC014579.1 BC015490.2

BC020216.1 BC040210.1 BT006653.1 BT007197.1 CR611068.1 D26124.1 M86609.1 S68290.1

U05684.1

24/31 DOTS entries (see all 31 ):

DT.91810606 DT.92462965 DT.97855879 DT.100889726 DT.92027039 DT.437774 DT.97776113 DT.92462917

DT.100889725 DT.100889730 DT.100889732 DT.121225152 DT.75180336 DT.121225243 DT.121225288 DT.121225228

DT.121225394 DT.91835807 DT.91906283 DT.92462948 DT.95268563 DT.100031708 DT.100031712 DT.92462921

24/413 AceView cDNA sequences (see all 413 ):

AF263242 CA314572 CB119580 CR598545 AA962456 BM975984 BM976106 CA425039

BC002862 CB108102 CR611068 CB108236 BU681702 NM_031436 BU732460 CB113447

CB108516 BM982500 CB108526 BU630856 BM981653 CB123903 AI205722 BM799067

highest scoring ESTs for AKR1C1:

BF208874 BQ232363 BQ310816 H54158 H69608 T11166 T53846 H65645 BC040210 CF128127

Unigene Cluster for AKR1C1:

Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

Hs.460260 [show with all ESTs]

Unigene Representative Sequence: AK226067

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000380859 ENST00000380872

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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AKR1C1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AKR1C1

¹ / ² / ³

8 probe-sets matching AKR1C1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32805_at²^{, 3}	U95-A	3	1.00	0.49	1.00	1.00	U05861	0.20	0.50	0.38	1
204151_x_at²^{, 3}	U133-A	4	1.00	0.52	--	--	NM_001353	0.20	0.11	0.16	2
216594_x_at²^{, 3}	U133-A	5	1.00	0.41	--	--	S68290	0.20	0.11	0.16	2
211653_x_at²	U133-A	6	0.82	0.25	--	--	--	--	--	--	--
204151_x_at²	U133Plus2	4	1.00	0.52	--	--	--	--	--	--	--
216594_x_at²	U133Plus2	5	1.00	0.41	--	--	--	--	--	--	--
211653_x_at²	U133Plus2	6	0.82	0.25	--	--	--	--	--	--	--
1562102_at*²	U133Plus2	1	0.27	1.00	--	--	--	--	--	--	--

GeneDecks AKR1C1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGGTCTGCCA

SOURCE GeneReport for Unigene cluster: Hs.460260
Expression variation in blood from EXPOLDB for AKR1C1
UniProtKB/Swiss-Prot: AK1C1_HUMAN, Q04828
Tissue specificity: Expressed in all tissues tested including liver, prostate, testis, adrenal
gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary
gland and brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AKR1C1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	AKR1C4¹	--	aldo-keto reductase family 1, member C4 (chlordecone more	83.08(n) 78.33(a)	282138 NM_181027.2 NP_851370.1
rat (Rattus norvegicus)	Akr1c21¹	--	aldo-keto reductase family 1, member C21	77.67(n) 71.07(a)	291283 NM_001013057.1 NP_001013075.1
mouse (Mus musculus)	Akr1c6⁵ Akr1c21¹	13 (8.00 cM)⁵	aldo-keto reductase family 1, member C6⁵ aldo-keto reductase family 1, member C21¹	77.71(n)¹ 73.37(a)¹	77337¹ NM_029901.2¹ NP_084177.2¹ AF110408⁵ AF110409⁵ (see all 14)
fruit fly (Drosophila melanogaster)	CG6084³	68C15	aldehyde reductase	50(a) (best of 7)	--
worm (Caenorhabditis elegans)	Y39G8B.1a³	II(13970799-13972831)	--	41(a) (best of 10)	--

About this table Species with no ortholog for AKR1C1

ENSEMBL Gene Tree for AKR1C1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for AKR1C1 gene

AKR1C2¹ ² tAKR² AKR1C3² AKR1CL1² AKR1C4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/154 NCBI SNPs in AKR1C1 are shown (see all 154 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 18)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs8483^1,2	A,C,F	5009959(+)	`GGTCTG/ACCAGA`	1	--	ut3¹ ese³		7		MN CSAM EA	760
	rs3898029^1,2	A,C,F	5010163(+)	`ACTTTG/CGTCTC`	1	--	ng3¹ ese³		10		NS MN NA EA	654
--	rs1139139^1,2	A,F	5010625(+)	`TCTTGT/CTCATA`	1	--	ng3¹ ese³		1		MN	184
--	rs2904795^1,2	A	4994317(+)	`ATTATA/C/GAAATT`	1	--	ng5¹		0	--	--	--	--
--	rs17354444^1,2	F	5001081(+)	`CAGGCA/TGCTGG`	1	Q/L	mis¹		1		MN	184
--	rs35289491^1,2	F	5009974(+)	`CCTGCG/ATGTGG`	1	--	ut3¹		5		MN CSAM EA	396
--	rs17295755^1,2	F	5001075(+)	`CAACCA/GCAGGC`	1	R/H	mis¹		1		MN	184
--	rs35763015^1,2	F	5009988(+)	`GTGACA/CCAGAG`	1	--	ut3¹		5		MN CSAM EA	392
--	rs11252852^1,2	A	4994015(+)	`CCCTCA/GTGATC`	1	--	ng5¹		0	--	--	--	--
--	rs1138570^1,2	H	4998134(+)	`GGCCAC/TCAAAT`	1	T/I	mis¹ ese³		4		EU EA WA	406

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HapMap Linkage Disequilibrium images for AKR1C1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600449

10/17 Novoseek disease relationships for AKR1C1 gene (see all 17 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
nsclc	41.29	25	11289154 (6), 16876904 (5), 17266043 (3), 11956619 (3) (see all 5)
ovarian carcinoma	38.23	4	17009030 (2), 15790446 (1), 15138708 (1)
endometrial cancer	34.77	4	16338060 (4), 19007763 (1), 18045204 (1)
colon carcinoma	33.93	4	9973208 (1), 8573067 (1)
lung tumor	28.03	3	17163506 (2), 16876904 (1)
prostate cancer	15.30	2	17283174 (1), 17878531 (1)
breast cancer	15.23	1	18045204 (1)
cancer lung	11.17	4	17163506 (3), 17266043 (1)
smoking habit	7.00	2	15197778 (1), 11956619 (1)
cancer	6.45	7	12579257 (1), 17094902 (1), 16876904 (1), 18214064 (1) (see all 7)

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Human Genome Epidemiology Navigator: AKR1C1 (3 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/117 PubMed articles for AKR1C1 gene (see all 117 ):

Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells. (PubMed id 8573067)^{1, 3, 4} Hara A....Ishida N. (1996)
Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes. (PubMed id 10672042)^{1, 3, 4} Nishizawa M.... Ito S. (2000)
Characterization of a human 20alpha-hydroxysteroid dehydrogenase. (PubMed id 11013348)^{1, 3, 4} Zhang Y.... Luu-The V. (2000)
Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding. (PubMed id 8132567)^{1, 3, 4} Lou H.... Stolz A. (1994)
cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family. (PubMed id 8486699)^{1, 3, 4} Stolz A.... Shively J.E. (1993)
Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics. (PubMed id 7515059)^{1, 3, 4} Ciaccio P.J.... Tew K.D. (1994)
Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids. (PubMed id 12899831)^{1, 3, 4} Couture J.-F....Breton R. (2003)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans. (PubMed id 7626489)^{3, 4} Khanna M.... Cheng K.-C. (1995)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1645	HGNC: 384	AceView: AKR1C1andAKR1CL2	Ensembl:ENSG00000187134	euGenes: HUgn1645
ECgene: AKR1C1	H-InvDB: AKR1C1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for AKR1C1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
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Enzo Life Sciences, and/or Tocris Bioscience)
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Products for AKR1C1:

TaqMan ® Gene Expression Assays

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AKR1C1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for AKR1C1

Summaries
for AKR1C1

Genomic Location
for AKR1C1

Proteins
for AKR1C1

Protein Domains/
Families
for AKR1C1

Gene Function
for AKR1C1

Pathways & Interactions
for AKR1C1

Drugs & Compounds
for AKR1C1

Transcripts
for AKR1C1

Expression
for AKR1C1

Orthologs
for AKR1C1

Paralogs
for AKR1C1

SNPs/Variants
for AKR1C1

Disorders & Mutations
for AKR1C1

Medical News
for AKR1C1

Publications
for AKR1C1

Search for AKR1C1

Genome Databases showing AKR1C1

Other Databases showing AKR1C1

Specialized Databases showing AKR1C1

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Services
for AKR1C1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AKR1C1 (Gene Symbol)
2-ALPHA-HSD
20-ALPHA-HSD
20-alpha-HSD
C9
DD1
DD1/DD2
DDH
DDH1
EC 1.1.1.-,EC 1.1.1.149,EC 1.3.1.20,EC 1.1.1.112
H-37
HAKRC
HBAB
MBAB
MGC8954
OTTHUMP00000018992
20 alpha-hydroxysteroid dehydrogenase
20-alpha-hydroxysteroid dehydrogenase
Chlordecone reductase homolog HAKRC
Dihydrodiol dehydrogenase 1/2
High-affinity hepatic bile acid-binding protein
Indanol dehydrogenase
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
aldo-keto reductase C
aldo-keto reductase family 1, member C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chlordecone reductase homolog
dihydrodiol dehydrogenase 1
dihydrodiol dehydrogenase isoform DD1
hepatic dihydrodiol dehydrogenase
type II 3-alpha-hydroxysteroid dehydrogenase

AKR1C1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor AKR1C1

Summariesfor AKR1C1

Genomic Locationfor AKR1C1

Proteinsfor AKR1C1

Protein Domains/Familiesfor AKR1C1

Gene Functionfor AKR1C1

Pathways & Interactionsfor AKR1C1

Drugs & Compoundsfor AKR1C1

Transcriptsfor AKR1C1

Expression for AKR1C1

Orthologsfor AKR1C1

Paralogsfor AKR1C1

SNPs/Variantsfor AKR1C1

Disorders & Mutationsfor AKR1C1

Medical Newsfor AKR1C1

Publicationsfor AKR1C1

Search for AKR1C1

Genome Databases showing AKR1C1

Other Databases showing AKR1C1

Specialized Databases showing AKR1C1

Licensable Technologiesfor AKR1C1

Servicesfor AKR1C1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AKR1C1

Summaries
for AKR1C1

Genomic Location
for AKR1C1

Proteins
for AKR1C1

Protein Domains/
Families
for AKR1C1

Gene Function
for AKR1C1

Pathways & Interactions
for AKR1C1

Drugs & Compounds
for AKR1C1

Transcripts
for AKR1C1

Expression
for AKR1C1

Orthologs
for AKR1C1

Paralogs
for AKR1C1

SNPs/Variants
for AKR1C1

Disorders & Mutations
for AKR1C1

Medical News
for AKR1C1

Publications
for AKR1C1

Licensable Technologies
for AKR1C1

Services
for AKR1C1