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Aliases for AKR1B15 Gene

Aliases for AKR1B15 Gene

  • Aldo-Keto Reductase Family 1 Member B15 2 3 5
  • Estradiol 17-Beta-Dehydrogenase AKR1B15 3 4
  • Putative Aldo-Keto Reductase Family 1 Member B15 3
  • AKR1B10L, AK1R1B7 3
  • EC 1.1.1.62 4
  • EC 1.1.1.- 4
  • AKR1B10L 3
  • AKR1R1B7 3

External Ids for AKR1B15 Gene

Previous GeneCards Identifiers for AKR1B15 Gene

  • GC07P133902
  • GC07P134233
  • GC07P128535

Summaries for AKR1B15 Gene

GeneCards Summary for AKR1B15 Gene

AKR1B15 (Aldo-Keto Reductase Family 1 Member B15) is a Protein Coding gene. Among its related pathways are Metabolism of steroid hormones and Metabolism. GO annotations related to this gene include oxidoreductase activity and estradiol 17-beta-dehydrogenase activity. An important paralog of this gene is AKR1B10.

UniProtKB/Swiss-Prot for AKR1B15 Gene

  • Isoform 1: Mainly acts as a reductive enzyme that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Has a strong selectivity towards NADP(H) (PubMed:25577493).

  • Isoform 2: No oxidoreductase activity observed with the tested substrates.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR1B15 Gene

Genomics for AKR1B15 Gene

Regulatory Elements for AKR1B15 Gene

Enhancers for AKR1B15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G134457 1.6 FANTOM5 ENCODE dbSUPER 33.3 -87.4 -87368 2.8 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF143 DEK SP3 NFYC REST AKR1B15 AKR1B1 LOC105375519
GH07G134531 1 ENCODE dbSUPER 47.4 -13.6 -13617 2.5 GTF2F1 PKNOX1 MXI1 NFIB JUN MAX SIN3A CHD7 RFX5 POLR2A AKR1B15 AKR1B10
GH07G134508 1.1 ENCODE dbSUPER 42.6 -35.3 -35324 4.4 CHAMP1 ZNF766 FOS CAVIN1 ELF4 ZNF592 TFDP1 MEF2D CREB3 ZNF589 AKR1B15 AKR1B1 AKR1B10 LOC100887077
GH07G134447 1.4 Ensembl ENCODE dbSUPER 33.2 -95.1 -95074 8.1 ATF1 CREB3L1 SIN3A TCF12 GATA2 FOS KLF13 ZNF592 CREB3 MAFF AKR1B15 AKR1B1 LOC105375519
GH07G134471 1 ENCODE dbSUPER 39.2 -74.1 -74104 2.1 SAP130 MLX JUN MAX CEBPG ZBTB40 ZNF644 FOSL1 FOS TRIM24 AKR1B15 LOC100887077 AKR1B10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AKR1B15 on UCSC Golden Path with GeneCards custom track

Genomic Location for AKR1B15 Gene

Chromosome:
7
Start:
134,546,245 bp from pter
End:
134,579,875 bp from pter
Size:
33,631 bases
Orientation:
Plus strand

Genomic View for AKR1B15 Gene

Genes around AKR1B15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKR1B15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKR1B15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR1B15 Gene

Proteins for AKR1B15 Gene

  • Protein details for AKR1B15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JRZ8-AK1BF_HUMAN
    Recommended name:
    Aldo-keto reductase family 1 member B15
    Protein Accession:
    C9JRZ8
    Secondary Accessions:
    • C9J3V2

    Protein attributes for AKR1B15 Gene

    Size:
    316 amino acids
    Molecular mass:
    36537 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AKR1B15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKR1B15 Gene

Post-translational modifications for AKR1B15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKR1B15 Gene

No data available for DME Specific Peptides for AKR1B15 Gene

Domains & Families for AKR1B15 Gene

Gene Families for AKR1B15 Gene

Protein Domains for AKR1B15 Gene

Suggested Antigen Peptide Sequences for AKR1B15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

C9JRZ8

UniProtKB/Swiss-Prot:

AK1BF_HUMAN :
  • Belongs to the aldo/keto reductase family.
Family:
  • Belongs to the aldo/keto reductase family.
genes like me logo Genes that share domains with AKR1B15: view

Function for AKR1B15 Gene

Molecular function for AKR1B15 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.8 uM for androsterone (tested with isoform 1 in the reductive reaction) {ECO:0000269 PubMed:25577493}; KM=1.9 uM for delta-4-androstenedione (tested with isoform 1 in the reductive reaction) {ECO:0000269 PubMed:25577493}; KM=2.5 uM for estrone (tested with isoform 1 in the reductive reaction) {ECO:0000269 PubMed:25577493}; KM=63.4 uM for acetoacetyl-CoA (tested with isoform 1 in the reductive reaction) {ECO:0000269 PubMed:25577493}; KM=19.2 uM for 3-alpha,17-beta-androstandiol (tested with isoform 1 in the oxidative reaction) {ECO:0000269 PubMed:25577493}; KM=7.1 uM for testosterone (tested with isoform 1 in the oxidative reaction) {ECO:0000269 PubMed:25577493}; KM=9.1 uM for 17-beta-estradiol (tested with isoform 1 in the oxidative reaction) {ECO:0000269 PubMed:25577493}; Note=kcat is 1.7 min(-1) using isoform 1 for the reduction of androsterone. kcat is 1.1 min(-1) using isoform 1 for the reduction of delta-4-androstenedione. kcat is 1.0 min(-1) using isoform 1 for the reduction of estrone. kcat is 0.5 min(-1) using isoform 1 for the reduction of acetoacetyl-CoA. kcat is 3.0 min(-1) using isoform 1 for the oxidation of 3-alpha,17- beta-androstandiol. kcat is 0.6 min(-1) using isoform 1 for the oxidation of testosterone. kcat is 0.5 min(-1) using isoform 1 for the oxidation of 17-beta-estradiol. {ECO:0000269 PubMed:25577493};
UniProtKB/Swiss-Prot CatalyticActivity:
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Isoform 1: Mainly acts as a reductive enzyme that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Has a strong selectivity towards NADP(H) (PubMed:25577493).
UniProtKB/Swiss-Prot Function:
Isoform 2: No oxidoreductase activity observed with the tested substrates.

Enzyme Numbers (IUBMB) for AKR1B15 Gene

Gene Ontology (GO) - Molecular Function for AKR1B15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004303 estradiol 17-beta-dehydrogenase activity TAS --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with AKR1B15: view

Phenotypes for AKR1B15 Gene

GenomeRNAi human phenotypes for AKR1B15:
genes like me logo Genes that share phenotypes with AKR1B15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AKR1B15 Gene

Localization for AKR1B15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR1B15 Gene

Isoform 1: Mitochondrion.
Isoform 2: Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKR1B15 gene
Compartment Confidence
mitochondrion 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for AKR1B15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix TAS --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with AKR1B15: view

Pathways & Interactions for AKR1B15 Gene

genes like me logo Genes that share pathways with AKR1B15: view

Pathways by source for AKR1B15 Gene

Gene Ontology (GO) - Biological Process for AKR1B15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006703 estrogen biosynthetic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with AKR1B15: view

No data available for SIGNOR curated interactions for AKR1B15 Gene

Drugs & Compounds for AKR1B15 Gene

No Compound Related Data Available

Transcripts for AKR1B15 Gene

mRNA/cDNA for AKR1B15 Gene

Unigene Clusters for AKR1B15 Gene

Aldo-keto reductase family 1, member B15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKR1B15 Gene

No ASD Table

Relevant External Links for AKR1B15 Gene

GeneLoc Exon Structure for
AKR1B15
ECgene alternative splicing isoforms for
AKR1B15

Expression for AKR1B15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AKR1B15 Gene

mRNA differential expression in normal tissues according to GTEx for AKR1B15 Gene

This gene is overexpressed in Muscle - Skeletal (x13.1), Stomach (x8.9), Esophagus - Mucosa (x6.4), and Vagina (x4.7).

Protein differential expression in normal tissues from HIPED for AKR1B15 Gene

This gene is overexpressed in Lung (26.7), Urine (23.4), and Saliva (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AKR1B15 Gene



Protein tissue co-expression partners for AKR1B15 Gene

NURSA nuclear receptor signaling pathways regulating expression of AKR1B15 Gene:

AKR1B15

SOURCE GeneReport for Unigene cluster for AKR1B15 Gene:

Hs.729418

mRNA Expression by UniProt/SwissProt for AKR1B15 Gene:

C9JRZ8-AK1BF_HUMAN
Tissue specificity: Widely expressed. Expressed at highest levels in steroid-sensitive tissues, such as placenta, testis and adipose tissue.

Evidence on tissue expression from TISSUES for AKR1B15 Gene

  • Eye(4.2)
genes like me logo Genes that share expression patterns with AKR1B15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKR1B15 Gene

Orthologs for AKR1B15 Gene

This gene was present in the common ancestor of animals.

Orthologs for AKR1B15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKR1B15 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akr1b10 35
  • 76 (a)
ManyToMany
Akr1b8 35
  • 75 (a)
ManyToMany
Akr1b7 35
  • 72 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 73 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-180p18.9 35
  • 60 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6084 35
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for AKR1B15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKR1B15 Gene

ENSEMBL:
Gene Tree for AKR1B15 (if available)
TreeFam:
Gene Tree for AKR1B15 (if available)

Paralogs for AKR1B15 Gene

Paralogs for AKR1B15 Gene

(11) SIMAP similar genes for AKR1B15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AKR1B15: view

Variants for AKR1B15 Gene

Sequence variations from dbSNP and Humsavar for AKR1B15 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000158376 -- 134,563,413(+) AGTGA(C/T)GGTGG intron-variant, upstream-variant-2KB
rs1000469036 -- 134,561,671(+) GCCAA(C/T)TCATC intron-variant, upstream-variant-2KB
rs1000507347 -- 134,551,708(+) CCCCC(A/C)TCACA intron-variant, nc-transcript-variant
rs1000525326 -- 134,571,216(+) GCAAG(A/G)ATAGA intron-variant
rs1000623721 -- 134,566,383(+) CTAGG(G/T)GGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKR1B15 Gene

Variant ID Type Subtype PubMed ID
dgv1240e199 CNV deletion 23128226
dgv430n21 CNV loss 19592680
dgv6636n100 CNV loss 25217958
esv26694 CNV loss 19812545
esv2669756 CNV deletion 23128226
esv2735180 CNV deletion 23290073
esv27674 CNV gain 19812545
esv3443026 CNV duplication 20981092
esv3615097 CNV loss 21293372
nsv1020141 CNV gain 25217958
nsv1026859 CNV loss 25217958
nsv1031083 CNV loss 25217958
nsv981584 CNV duplication 23825009

Variation tolerance for AKR1B15 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKR1B15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKR1B15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKR1B15 Gene

Disorders for AKR1B15 Gene

Relevant External Links for AKR1B15

Genetic Association Database (GAD)
AKR1B15
Human Genome Epidemiology (HuGE) Navigator
AKR1B15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKR1B15

No disorders were found for AKR1B15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKR1B15 Gene

Publications for AKR1B15 Gene

  1. Aldo-keto reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity towards steroids and 3-keto-acyl-coa conjugates. (PMID: 25577493) Weber S. … Barski O.A. (J. Biol. Chem. 2015) 3 4 64
  2. Functional expression of novel human and murine AKR1B genes. (PMID: 21276782) Salabei J.K. … Barski O.A. (Chem. Biol. Interact. 2011) 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin A.I. … Ukraintseva S.V. (Aging (Albany NY) 2010) 3 46 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for AKR1B15 Gene

Sources for AKR1B15 Gene

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