Aliases for AKR1B15 Gene
External Ids for AKR1B15 Gene
Previous GeneCards Identifiers for AKR1B15 Gene
GeneCards Summary for AKR1B15 Gene
AKR1B15 (Aldo-Keto Reductase Family 1, Member B15) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is AKR1B1.
UniProtKB/Swiss-Prot for AKR1B15 Gene
Isoform 1: Mainly acts as a reductive enzyme that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Has a strong selectivity towards NADP(H) (PubMed:25577493).
Isoform 2: No oxidoreductase activity observed with the tested substrates.