AKR1B15 Gene
protein-coding GIFtS: 31
GCID: GC07P134233
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aldo-keto reductase family 1, member B15
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Aliases
for AKR1B15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Aldo-Keto Reductase Family 1, Member B151 2 | | AKR1B10L2 | | Aldo-Keto Reductase Family 1 Member B152 | | Putative Aldo-Keto Reductase Family 1 Member B152 | | EC 1.1.1.-3 |
Export aliases for AKR1B15 gene to outside databasesPrevious GC identifers: GC07P133902 GC07P128535 |
Summaries
for AKR1B15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AK1BF_HUMAN, C9JRZ8Function: Possesses weak oxidoreductase activity
|
Genomic Views
for AKR1B15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for AKR1B15
Other transcription factors
Search SABiosciences Chromatin IP Primers for AKR1B15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKR1B15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q33 Ensembl cytogenetic band: 7q33 HGNC cytogenetic band: 7q33AKR1B15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P134233: view genomic region
(about GC identifiers)
Start:
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134,233,849 bp from pter |
End:
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134,264,592 bp from pter |
Size:
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30,744 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 133,578,165-133,608,909 |
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Proteins
for AKR1B15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AK1BF_HUMAN, C9JRZ8 (See
protein sequence)Recommended Name: Aldo-keto reductase family 1 member B15 Size: 344 amino acids; 39460 Da
Secondary accessions: C9J3V2Alternative splicing: 2 isoforms: C9JRZ8-1 C9JRZ8-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for AKR1B15: NX_C9JRZ8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_C9JRZ8
AKR1B15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001074007.2
ENSEMBL proteins: ENSP00000389289 ENSP00000397009
Human Recombinant Protein Products:
AKR1B15 Antibody Products:
Assay Products for AKR1B15: |
Protein
Domains /
Families
for AKR1B15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AKR1B15 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry C9JRZ8ProtoNet protein and cluster: C9JRZ8 UniProtKB/Swiss-Prot: AK1BF_HUMAN, C9JRZ8Similarity: Belongs to the aldo/keto reductase family |
Function
for AKR1B15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AK1BF_HUMAN, C9JRZ8Function: Possesses weak oxidoreductase activityEnzyme Number (IUBMB): EC 1.1.1.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKR1B15
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016491 | oxidoreductase activity |
IEA | -- |
AKR1B15 for ontologies About GeneDecksing
|
Pathways & Interactions
for AKR1B15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AKR1B15
|
Drugs & Compounds
for AKR1B15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AKR1B15
Search CenterWatch for drugs/clinical trials and news about AKR1B15 / AK1BF
|
Transcripts
for AKR1B15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AKR1B15 gene: NM_001080538.2 Unigene Cluster for AKR1B15: Aldo-keto reductase family 1, member B15 Hs.729418 [show with all ESTs]Unigene Representative Sequence: BC0726763 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000457545(uc011kpr.2) ENST00000467156 ENST00000423958
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKR1B15
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKR1B15
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AKR1B15 (NM_001080538) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AKR1B15 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AKR1B15 |
Additional cDNA sequence: BC072676.1 6 DOTS entries: DT.100783869 DT.100768987 DT.100783870 DT.208348 DT.100783868 DT.92430986 24/163 AceView cDNA sequences (see all 163): BQ224299 BQ949571 BQ940536 CB119937 BC072676 BQ227150 CR612412 BU164592 BU175462 BX337599 BQ230079 BU168299 BM783186 AA365080 CB106577 BQ224413 CR607509 BQ229376 BE786484 CB106637 BQ430693 BQ231252 NM_020299 BC008837
GeneLoc Exon Structure
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Expression
for AKR1B15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AKR1B15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See AKR1B15 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.729418
SABiosciences Custom PCR Arrays for AKR1B15
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKR1B15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AKR1B15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKR1B15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKR1B15 |
Orthologs
for AKR1B15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for AKR1B15 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for AKR1B15 (if available)
TreeFam Gene Tree for AKR1B15 (if available) |
Paralogs
for AKR1B15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AKR1B15 gene
- AKR1C22 AKR1CL12 AKR1C32 AKR1B102 AKR1A12 AKR1C42 AKR1E22 AKR1D12
- AKR1B12 AKR1C12
11 SIMAP similar genes for AKR1B15 using alignment to 1 protein entry: AK1BF_HUMAN:AKR1B10 AKR1B1 LOC402299 AKR1C4 AKR1CL1 AKR1C1
AKR1C3 AKR1D1 AKR1E2 AKR1A1 AKR1C2
AKR1B15 for paralogs About GeneDecksing
|
Genomic Variants
for AKR1B15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AKR1B15 (134233849 - 134264592 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for AKR1B15
1 CNV: 70044 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKR1B15 |
|
Disorders
/ Diseases
for AKR1B15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 AKR1B15 for disorders About MalaCards
AKR1B15 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: AKR1B15 (1 document)
Export disorders for AKR1B15 gene to outside databases
|
Publications
for AKR1B15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AKR1B15 gene integrated from 9 sources:
(articles sorted by number of sources associating them with AKR1B15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional expression of novel human and murine AKR1B genes. (PubMed id 21276782)1, 2 Salabei J.K.... Barski O.A. (2011)
- Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing. (PubMed id 22277967)1 Calvo S.E.... Mootha V.K. (2012)
- Joint influence of small-effect genetic variants on h uman longevity. (PubMed id 20834067)1 Yashin A.I....Ukraintseva S.V. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for AKR1B15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing AKR1B15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AKR1B15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AKR1B15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AKR1B15 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for AKR1B15 gene:
Search GeneIP for patents involving AKR1B15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AKR1B15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | AKR1B15 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for AKR1B15 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AKR1B15 |
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