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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AKR1B15 Gene

protein-coding   GIFtS: 32
GCID: GC07P134233

Aldo-Keto Reductase Family 1, Member B15

  Search for AKR1B15
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Aldo-Keto Reductase Family 1, Member B151 2
AKR1B10L2
Aldo-Keto Reductase Family 1 Member B152
Putative Aldo-Keto Reductase Family 1 Member B152
EC 1.1.1.-3

External Ids:    HGNC: 372811   Entrez Gene: 4412822   Ensembl: ENSG000002274717   UniProtKB: C9JRZ83   

Export aliases for AKR1B15 gene to outside databases

Previous GC identifers: GC07P133902 GC07P128535


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AKR1B15 Gene: 
AKR1B15 (aldo-keto reductase family 1, member B15) is a protein-coding gene. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is AKR1C2.

UniProtKB/Swiss-Prot: AK1BF_HUMAN, C9JRZ8
Function: Possesses weak oxidoreductase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for AKR1B15
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKR1B15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q33

AKR1B15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKR1B15 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P134233:  view genomic region     (about GC identifiers)

Start:
134,233,849 bp from pter      End:
134,264,627 bp from pter
Size:
30,779 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 133,578,165-133,608,909     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AK1BF_HUMAN, C9JRZ8 (See protein sequence)
Recommended Name: Aldo-keto reductase family 1 member B15  
Size: 344 amino acids; 39460 Da
Secondary accessions: C9J3V2
Alternative splicing: 2 isoforms:  C9JRZ8-1   C9JRZ8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AKR1B15: NX_C9JRZ8

Explore proteomics data for AKR1B15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_C9JRZ8

  • AKR1B15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AKR1B15 Protein Expression
    REFSEQ proteins: NP_001074007.2  
    ENSEMBL proteins: 
     ENSP00000389289   ENSP00000397009  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AKR: Aldo-keto reductases

    4 InterPro protein domains:
     IPR001395 Aldo/ket_red
     IPR018170 Aldo/ket_reductase_CS
     IPR020471 Aldo/keto_reductase_subgr
     IPR023210 NADP_OxRdtase_dom

    Graphical View of Domain Structure for InterPro Entry C9JRZ8

    ProtoNet protein and cluster: C9JRZ8

    UniProtKB/Swiss-Prot: AK1BF_HUMAN, C9JRZ8
    Similarity: Belongs to the aldo/keto reductase family


    AKR1B15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AK1BF_HUMAN, C9JRZ8
    Function: Possesses weak oxidoreductase activity

         Enzyme Number (IUBMB): EC 1.1.1.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491oxidoreductase activity IEA--
         
    AKR1B15 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AKR1B15

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for AKR1B15 (AK1BF)

    Search CenterWatch for drugs/clinical trials and news about AKR1B15 / AK1BF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for AKR1B15 gene: 
    NM_001080538.2  

    Unigene Cluster for AKR1B15:

    Aldo-keto reductase family 1, member B15
    Hs.729418  [show with all ESTs]
    Unigene Representative Sequence: BC072676
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457545(uc011kpr.2) ENST00000467156 ENST00000423958
    miRNA
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    Additional mRNA sequence: BC072676.1 

    6 DOTS entries:

    DT.100783869  DT.100768987  DT.100783870  DT.208348  DT.100783868  DT.92430986 

    24/163 AceView cDNA sequences (see all 163):

    CB106577 BM783186 AA365080 CB119937 BQ940536 BQ224413 BQ229376 CR607509 
    BU175693 CB120598 BQ949452 BM837946 BU168299 BU164592 BC072676 BQ949571 
    CR612412 BQ227150 CB119917 BC008837 BQ430693 BQ231252 BE786484 NM_020299 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AKR1B15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AKR1B15 Expression
    About this image


    See AKR1B15 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.729418
        SABiosciences Custom PCR Arrays for AKR1B15
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKR1B15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AKR1B15 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-180p18.96
    akr1b16
    si:dkey-180p18.9
    aldo-keto reductase family 1, member B1 (aldose re...
    60(a)
    58(a)
    many ↔ many
    many ↔ many
    4(13972000-13980660)
    4(13965330-13971908)
            Species with no ortholog for AKR1B15

    ENSEMBL Gene Tree for AKR1B15 (if available)
    TreeFam Gene Tree for AKR1B15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AKR1B15 gene
    AKR1C22  AKR1CL12  AKR1C32  AKR1B102  AKR1A12  AKR1C42  AKR1E22  AKR1B12  
    AKR1D12  AKR1C12  
    11 SIMAP similar genes for AKR1B15 using alignment to 1 protein entry:     AK1BF_HUMAN:
    AKR1B10    AKR1B1    LOC402299    AKR1C4    AKR1CL1    AKR1C1
    AKR1C3    AKR1D1    AKR1E2    AKR1A1    AKR1C2

    AKR1B15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/841 SNPs in AKR1B15 are shown (see all 841)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895423481,2
    --134232057(+) TTATGC/GTAAAG 1 -- us2k10--------
    rs69559651,2
    C,H--134232084(+) agagaA/Cccaag 1 -- us2k16Minor allele frequency- C:0.00NS EA NA 420
    rs764166211,2
    C,F--134232165(+) CACTTT/CTCTGG 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1814378461,2
    --134232215(+) TTAATC/GAAATA 1 -- us2k10--------
    rs1861180741,2
    --134232263(+) ATTACA/GCCCTC 1 -- us2k10--------
    rs1160598151,2
    C,F--134232280(+) CGGCAG/CGGACC 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs790195041,2
    C,F--134232464(+) CCTCCG/AGCTGT 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1908087951,2
    --134232518(+) TGTGCC/TGTCCC 1 -- us2k10--------
    rs798707271,2
    F--134232578(+) CCAAGG/TTAAAA 1 -- us2k10--------
    rs8898771,2
    C,F,A,H--134232615(+) gagatC/Taccaa 1 -- us2k121Minor allele frequency- T:0.43NS EA NA WA CSA 2347

    HapMap Linkage Disequilibrium report for AKR1B15 (134233849 - 134264627 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for AKR1B15:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1240e199CNV Deletion23128226
    esv2669756CNV Deletion23128226
    esv2735180CNV Deletion23290073
    esv26694CNV Loss19812545
    dgv430n21CNV Loss19592680
    nsv889222CNV Gain21882294
    esv27674CNV Gain19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    AKR1B15 for disorders           About MalaCards

    AKR1B15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AKR1B15
    Human Genome Epidemiology (HuGE) Navigator: AKR1B15 (1 document)

    Export disorders for AKR1B15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AKR1B15 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with AKR1B15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional expression of novel human and murine AKR1B genes. (PubMed id 21276782)1, 2 Salabei J.K.... Barski O.A. (2011)
    2. Joint influence of small-effect genetic variants on h uman longevity. (PubMed id 20834067)1, 4 Yashin A.I....Ukraintseva S.V. (2010)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing. (PubMed id 22277967)1 Calvo S.E.... Mootha V.K. (2012)
    5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    6. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (2007)
    7. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 441282 HGNC: 37281 AceView: AKR1B10 Ensembl:ENSG00000227471 euGenes: HUgn441282
    ECgene: AKR1B15 H-InvDB: AKR1B15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AKR1B15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AKR1B15 gene:
    Search GeneIP for patents involving AKR1B15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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