Aliases for AKR1B15 Gene
External Ids for AKR1B15 Gene
Previous GeneCards Identifiers for AKR1B15 Gene
GeneCards Summary for AKR1B15 Gene
AKR1B15 (Aldo-Keto Reductase Family 1, Member B15) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of steroid hormones and vitamin D. GO annotations related to this gene include oxidoreductase activity and estradiol 17-beta-dehydrogenase activity. An important paralog of this gene is AKR1B1.
UniProtKB/Swiss-Prot for AKR1B15 Gene
Isoform 1: Mainly acts as a reductive enzyme that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Has a strong selectivity towards NADP(H) (PubMed:25577493).
Isoform 2: No oxidoreductase activity observed with the tested substrates.