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Aliases for AKR1B10 Gene

Aliases for AKR1B10 Gene

  • Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) 2 3 5
  • Aldose Reductase-Related Protein 2 3 4
  • Small Intestine Reductase 2 3 4
  • Aldose Reductase-Like Peptide 2 3
  • Aldose Reductase-Like 1 2 3
  • SI Reductase 3 4
  • AKR1B11 3 4
  • ARL-1 3 4
  • HARP 3 4
  • ARP 3 4
  • Aldo-Keto Reductase Family 1, Member B11 (Aldose Reductase-Like) 3
  • Member B11 (Aldose Reductase-Like) 2
  • Aldo-Keto Reductase Family 1 2
  • Aldose Reductase-Like 4
  • EC 1.1.1.21 63
  • EC 1.1.1.- 4
  • EC 1.1.1 63
  • AKR1B12 3
  • ALDRLn 3
  • ARL1 3
  • HIS 3
  • HSI 3

External Ids for AKR1B10 Gene

Previous HGNC Symbols for AKR1B10 Gene

  • AKR1B11

Previous GeneCards Identifiers for AKR1B10 Gene

  • GC07P132555
  • GC07P133614
  • GC07P133628
  • GC07P133669
  • GC07P133862
  • GC07P134212
  • GC07P128514

Summaries for AKR1B10 Gene

Entrez Gene Summary for AKR1B10 Gene

  • This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKR1B10 Gene

AKR1B10 (Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase)) is a Protein Coding gene. Diseases associated with AKR1B10 include hepatocellular carcinoma and nicotine dependence, protection against. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include aldo-keto reductase (NADP) activity and indanol dehydrogenase activity. An important paralog of this gene is AKR1B1.

UniProtKB/Swiss-Prot for AKR1B10 Gene

  • Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.

Gene Wiki entry for AKR1B10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR1B10 Gene

Genomics for AKR1B10 Gene

Regulatory Elements for AKR1B10 Gene

Promoters for AKR1B10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AKR1B10 on UCSC Golden Path with GeneCards custom track

Genomic Location for AKR1B10 Gene

Chromosome:
7
Start:
134,527,592 bp from pter
End:
134,541,414 bp from pter
Size:
13,823 bases
Orientation:
Plus strand

Genomic View for AKR1B10 Gene

Genes around AKR1B10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKR1B10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKR1B10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR1B10 Gene

Proteins for AKR1B10 Gene

  • Protein details for AKR1B10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60218-AK1BA_HUMAN
    Recommended name:
    Aldo-keto reductase family 1 member B10
    Protein Accession:
    O60218
    Secondary Accessions:
    • A4D1P1
    • O75890
    • Q6FHF3
    • Q8IWZ1

    Protein attributes for AKR1B10 Gene

    Size:
    316 amino acids
    Molecular mass:
    36020 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for AKR1B10 Gene

neXtProt entry for AKR1B10 Gene

Proteomics data for AKR1B10 Gene at MOPED

Post-translational modifications for AKR1B10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKR1B10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for AKR1B10 Gene

Gene Families for AKR1B10 Gene

Protein Domains for AKR1B10 Gene

Suggested Antigen Peptide Sequences for AKR1B10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60218

UniProtKB/Swiss-Prot:

AK1BA_HUMAN :
  • Belongs to the aldo/keto reductase family.
Family:
  • Belongs to the aldo/keto reductase family.
genes like me logo Genes that share domains with AKR1B10: view

Function for AKR1B10 Gene

Molecular function for AKR1B10 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=600 uM for D,L-glyceraldehyde {ECO:0000269 PubMed:18087047}; KM=0.6 uM for all-trans-retinaldehyde {ECO:0000269 PubMed:18087047}; KM=0.7 uM for 9-cis-retinaldehyde {ECO:0000269 PubMed:18087047};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by tolrestat.
UniProtKB/Swiss-Prot Function:
Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.

Enzyme Numbers (IUBMB) for AKR1B10 Gene

Gene Ontology (GO) - Molecular Function for AKR1B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18056116
GO:0016491 oxidoreductase activity IEA --
GO:0045550 geranylgeranyl reductase activity IDA 21187079
genes like me logo Genes that share ontologies with AKR1B10: view
genes like me logo Genes that share phenotypes with AKR1B10: view

Animal Models for AKR1B10 Gene

MGI Knock Outs for AKR1B10:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AKR1B10 Gene

Localization for AKR1B10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR1B10 Gene

Lysosome. Secreted. Note=Secreted through a lysosome-mediated non-classical pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKR1B10 Gene COMPARTMENTS Subcellular localization image for AKR1B10 gene
Compartment Confidence
cytosol 5
extracellular 5
vacuole 4
lysosome 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for AKR1B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with AKR1B10: view

Pathways & Interactions for AKR1B10 Gene

genes like me logo Genes that share pathways with AKR1B10: view

Gene Ontology (GO) - Biological Process for AKR1B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0008202 steroid metabolic process TAS 9565553
GO:0016488 farnesol catabolic process IDA 21187079
GO:0044598 doxorubicin metabolic process IMP 20837989
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with AKR1B10: view

No data available for SIGNOR curated interactions for AKR1B10 Gene

Drugs & Compounds for AKR1B10 Gene

(10) Drugs for AKR1B10 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2'-Monophosphoadenosine 5'-Diphosphoribose Experimental Pharma Target 0
3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID Experimental Pharma Target 0
1,2-Propanediol Experimental Pharma 0
D-Xylitol Experimental Pharma 0
Glycerol Experimental Pharma 191

(12) Additional Compounds for AKR1B10 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Alpha-D-Glucose
  • a-D-Glucopyranose
  • a-D-Glucose
  • a-Dextrose
  • a-Glucose
  • alpha-D-Glucopyranose
492-62-6
Beta-D-Galactose
  • b-D-Galactose
  • b-Galactose
  • beta D-Galactose
  • beta-D-Galactopyranose
  • beta-D-Galactose
7296-64-2
D-Xylose
  • D-(+)-Xylose
  • D-Xylo-pentose
  • D-Xylose
  • Wood sugar
  • Xylo-pfan
58-86-6
Galactitol
  • Ambap5938
  • D-Dulcitol
  • Dulcite
  • Dulcitol
  • Dulcose
608-66-2
glyceraldehyde
  • (+/-)-2,3-dihydroxy-Propanal
  • (+/-)-Glyceraldehyde
  • 2,3-Dihydroxypropanal
  • 2,3-Dihydroxypropionaldehyde
  • alpha,beta-Dihydroxypropionaldehyde
56-82-6
genes like me logo Genes that share compounds with AKR1B10: view

Transcripts for AKR1B10 Gene

Unigene Clusters for AKR1B10 Gene

Aldo-keto reductase family 1, member B10 (aldose reductase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKR1B10 Gene

No ASD Table

Relevant External Links for AKR1B10 Gene

GeneLoc Exon Structure for
AKR1B10
ECgene alternative splicing isoforms for
AKR1B10

Expression for AKR1B10 Gene

mRNA expression in normal human tissues for AKR1B10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AKR1B10 Gene

This gene is overexpressed in Stomach (x15.4), Esophagus - Mucosa (x10.4), Vagina (x5.6), Colon - Transverse (x4.4), and Bladder (x4.2).

Protein differential expression in normal tissues from HIPED for AKR1B10 Gene

This gene is overexpressed in Pancreatic juice (20.0), Stomach (11.5), Cardia (10.2), and Islet of Langerhans (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKR1B10 Gene



SOURCE GeneReport for Unigene cluster for AKR1B10 Gene Hs.116724

mRNA Expression by UniProt/SwissProt for AKR1B10 Gene

O60218-AK1BA_HUMAN
Tissue specificity: Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.
genes like me logo Genes that share expression patterns with AKR1B10: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for AKR1B10 Gene

Orthologs for AKR1B10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AKR1B10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AKR1B10 35
  • 83.98 (n)
  • 79.68 (a)
-- 36
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Akr1b8 35
  • 81.43 (n)
  • 82.28 (a)
Akr1b8 16
Akr1b10 36
  • 83 (a)
ManyToMany
Akr1b7 36
  • 80 (a)
ManyToMany
Akr1b8 36
  • 82 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia AKR1B10 35
  • 99.05 (n)
  • 99.05 (a)
AKR1B10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akr1b8 35
  • 81.43 (n)
  • 81.65 (a)
chicken
(Gallus gallus)
Aves AKR1B10 35
  • 71.9 (n)
  • 69.87 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-180p18.9 36
  • 66 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH10614 37
  • 42 (a)
CG10638 37
  • 42 (a)
CG12766 37
  • 47 (a)
CG2767 37
  • 42 (a)
CG6083 37
  • 47 (a)
CG6084 37
  • 61 (a)
CG9436 37
  • 38 (a)
CG6084 35
  • 62.37 (n)
  • 60.97 (a)
CG6084 36
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C01G5.5 37
  • 30 (a)
C07D8.6 37
  • 40 (a)
C35D10.6 37
  • 32 (a)
F53F1.2 37
  • 35 (a)
F53F1.3 37
  • 35 (a)
T08H10.1 37
  • 46 (a)
Y39G8B.1a 37
  • 44 (a)
Y39G8B.1b 37
  • 45 (a)
Y39G8B.2 37
  • 34 (a)
ZC443.1 37
  • 35 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL107C 35
  • 50.29 (n)
  • 40.89 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21627g 35
  • 50.06 (n)
  • 45.73 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRE3 35
  • 49.14 (n)
  • 43.99 (a)
ARA1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G21250 35
  • 48.62 (n)
  • 43.45 (a)
rice
(Oryza sativa)
Liliopsida Os02g0123500 35
  • 49.94 (n)
  • 42.56 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1520 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08384 35
  • 52.61 (n)
  • 43.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for AKR1B10:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AKR1B10 Gene

ENSEMBL:
Gene Tree for AKR1B10 (if available)
TreeFam:
Gene Tree for AKR1B10 (if available)

Paralogs for AKR1B10 Gene

(11) SIMAP similar genes for AKR1B10 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for AKR1B10 Gene

genes like me logo Genes that share paralogs with AKR1B10: view

Variants for AKR1B10 Gene

Sequence variations from dbSNP and Humsavar for AKR1B10 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs4728329 - 134,541,075(+) CCTTC(A/G)ATGCA nc-transcript-variant, reference, missense
rs2303312 - 134,531,932(+) AGAGA(C/G/T)CCCTT intron-variant, nc-transcript-variant, reference, missense
rs3735042 - 134,538,966(+) GGAGA(C/T)GGCAA nc-transcript-variant, reference, missense
rs697534 -- 134,526,253(+) ggcac(C/G)atctt upstream-variant-2KB
rs697535 -- 134,525,864(+) ctttc(A/G)tgatt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for AKR1B10 Gene

Variant ID Type Subtype PubMed ID
nsv889222 CNV Gain 21882294
esv2669756 CNV Deletion 23128226
dgv430n21 CNV Loss 19592680
esv2735180 CNV Deletion 23290073
dgv1240e199 CNV Deletion 23128226

Variation tolerance for AKR1B10 Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKR1B10 Gene

HapMap Linkage Disequilibrium report
AKR1B10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKR1B10 Gene

Disorders for AKR1B10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for AKR1B10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
nicotine dependence, protection against
  • nicotine dependence
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for AKR1B10

Genetic Association Database (GAD)
AKR1B10
Human Genome Epidemiology (HuGE) Navigator
AKR1B10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKR1B10
genes like me logo Genes that share disorders with AKR1B10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AKR1B10 Gene

Publications for AKR1B10 Gene

  1. Identification and characterization of a novel human aldose reductase-like gene. (PMID: 9565553) Cao D. … Chung S.S.M. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family. (PMID: 9765596) Hyndman D.J. … Flynn T.G. (Biochim. Biophys. Acta 1998) 2 3 23
  3. Structure and promoter characterization of aldo-keto reductase family 1 B10 gene. (PMID: 19236911) Liu Z. … Cao D. (Gene 2009) 3 23
  4. Kinetic studies of AKR1B10, human aldose reductase-like protein: endogenous substrates and inhibition by steroids. (PMID: 19464995) Endo S. … Hara A. (Arch. Biochem. Biophys. 2009) 3 23
  5. Aldo-keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels. (PMID: 19563777) Zhong L. … Cao D. (Biochem. Biophys. Res. Commun. 2009) 3 23

Products for AKR1B10 Gene

Sources for AKR1B10 Gene

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