Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AKR1B10 Gene

protein-coding   GIFtS: 65
GCID: GC07P134212

aldo-keto reductase family 1, member B10 (aldose reductase)


(Previous symbol: AKR1B11)
 Explore 27 diseases affiliated with
AKR1B10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AKR1B10    

Aliases
for AKR1B10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase)1 2     HARP1
AKR1B111 2 3     SI Reductase2 3
ARL-11 2 3     Aldo-Keto Reductase Family 1 Member B102
AKR1B121 2     Aldo-Keto Reductase Family 1, Member B11 (Aldose Reductase-Like)2
ALDRLn1 2     Aldose Reductase-Like 12
ARL11 2     Aldose Reductase-Like Peptide2
HIS1 2     EC 1.1.1.-3
HSI1 2     Aldose Reductase-Like3
Aldose Reductase-Related Protein2 3     EC 1.1.18
Small Intestine Reductase2 3     EC 1.1.1.218
ARP2 3     

External Ids:    HGNC: 3821   Entrez Gene: 570162   Ensembl: ENSG000001980747   OMIM: 6047075   UniProtKB: O602183   

Export aliases for AKR1B10 gene to outside databases

Previous GC identifers: GC07P132555 GC07P133614 GC07P133628 GC07P133669 GC07P133862 GC07P128514


Summaries
for AKR1B10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AKR1B10:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and
proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is
highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AK1BA_HUMAN, O60218
Function: Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is
less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food
before the nutrients are passed on to other organs

Gene Wiki entry for AKR1B10


Genomic Views
for AKR1B10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AKR1B10 gene promoter:
         SRF   AhR   SRF (504 AA)   Egr-1   Egr-4   YY1   Arnt   Evi-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): AKR1B10 promoter sequence
   Search SABiosciences Chromatin IP Primers for AKR1B10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKR1B10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q33

AKR1B10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKR1B10 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P134212:  view genomic region     (about GC identifiers)

Start:
 134,212,344 bp from pter      End:
 134,226,166 bp from pter
Size:
 13,823 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 133,556,663-133,570,483     

Proteins
for AKR1B10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AK1BA_HUMAN, O60218 (See protein sequence)
Recommended Name: Aldo-keto reductase family 1 member B10  
Size: 316 amino acids; 36020 Da
Subcellular location: Lysosome. Secreted. Note=Secreted through a lysosome-mediated non-classical pathway
1 PDB 3D structure from and Proteopedia for AKR1B10:
1ZUA (3D)    
Secondary accessions: A4D1P1 O75890 Q6FHF3 Q8IWZ1

Explore the universe of human proteins at neXtProt for AKR1B10: NX_O60218

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60218

    • 4/11 DME Specific Peptides for AKR1B10 (O60218) (see all 11)
     IPKSVTP  GLGTWKS  NIQVFDF  LFIVSKLW 

    AKR1B10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_064695.3  
    ENSEMBL proteins: 
     ENSP00000352584  
    Reactome Protein details: O60218
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for AKR1B10 (Aldo-keto Reductase 1B10/AKR1B10)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: AKR1B10
    OriGene Protein Over-expression Lysate: AKR1B10
    OriGene Custom Protein Services for AKR1B10 
    GenScript Custom Purified and Recombinant Proteins Services for AKR1B10
    Novus Biologicals AKR1B10 Proteins
    Novus Biologicals AKR1B10 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for AKR1B10
    Uscn Proteins for AKR1B10

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--
    GO:0005764lysosome IEA--


    AKR1B10 for ontologies           About GeneDecksing



    AKR1B10 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): AKR1B10
    OriGene Custom Antibody Services for AKR1B10 
    GenScript Custom Superior Antibodies Services for AKR1B10
    Novus Biologicals AKR1B10 Antibodies
    Abcam antibodies for AKR1B10 
    Uscn Antibodies for AKR1B10
    ThermoFisher Antibody for AKR1B10

    Assay Products for AKR1B10: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AKR1B10
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for AKR1B10

    Protein Domains /
    Families
    for AKR1B10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AKR1B10 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001395 Aldo/ket_red
     IPR018170 Aldo/ket_reductase_CS
     IPR020471 Aldo/keto_reductase_subgr
     IPR023210 NADP_OxRdtase_dom

    Graphical View of Domain Structure for InterPro Entry O60218

    ProtoNet protein and cluster: O60218

    1 Blocks protein family: IPB001395 Aldo/keto reductase

    UniProtKB/Swiss-Prot: AK1BA_HUMAN, O60218
    Similarity: Belongs to the aldo/keto reductase family


    Function
    for AKR1B10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AK1BA_HUMAN, O60218
    Function: Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is
    less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food
    before the nutrients are passed on to other organs
    Enzyme regulation: Inhibited by tolrestat
    Biophysicochemical properties: Kinetic parameters: KM=600 uM for D,L-glyceraldehyde; KM=0.6 uM for
    all-trans-retinaldehyde; KM=0.7 uM for 9-cis-retinaldehyde;

    Enzyme Numbers (IUBMB): EC 1.1.1.212 EC 1.1.12 EC 1.1.1.-1

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKR1B10
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AKR1B10
    SwitchGear 3'UTR luciferase reporter plasmid: AKR1B10 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKR1B10 (see all 7)
    OriGene shRNA RFP: AKR1B10
    OriGene siRNA: AKR1B10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKR1B10

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for AKR1B10

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKR1B10 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKR1B10
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: AKR1B10 (NM_020299)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKR1B10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKR1B10 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for AKR1B10
    Search LifeMap BioReagents cell lines for AKR1B10

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKR1B10

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001758retinal dehydrogenase activity IDA--
    GO:0004033aldo-keto reductase (NADP) activity TAS9565553
    GO:0005515protein binding IPI18056116
    GO:0045550geranylgeranyl reductase activity IDA--
    GO:0047718indanol dehydrogenase activity IDA--


    AKR1B10 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for AKR1B10:
     Increased cell number in G2M,  


    Pathways & Interactions
    for AKR1B10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Retinoid metabolism and transport
    		Retinoid metabolism and transport1.00
    		Diseases associated with visual transduction0.73
    		Visual phototransduction0.74
    2acetone degradation I (to methylglyoxal)
    		acetone degradation I (to methylglyoxal)1.00
    		methylglyoxal degradation III0.38
    3Disease
    		Disease1.00
    4Fructose and mannose metabolism
    		Fructose and mannose metabolism1.00
    5Signaling by GPCR
    		Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for AKR1B10 
        acetone degradation I (to methylglyoxal)
    methylglyoxal degradation III
    metapathway biotransformation

    5        Reactome Pathways for AKR1B10
        Diseases associated with visual transduction
    Retinoid metabolism and transport
    Signal Transduction
    Visual phototransduction
    Disease

    1 PharmGKB Pathway for AKR1B10
        Cyclophosphamide Pathway, Pharmacodynamics

    4         Kegg Pathways  (Kegg details for AKR1B10):
        Fructose and mannose metabolism
    Linoleic acid metabolism
    Butanoate metabolism
    Metabolic pathways


    AKR1B10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AKR1B10

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for AKR1B10 (O602181, 3 ENSP000003525844) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACACAQ130851, 3, ENSP000003447894EBI-1572139,EBI-717681 I2D: score=2 STRING: ENSP00000344789
    DYNLL2Q96FJ23I2D: score=1 
    TERF2IPENSP000003000864STRING: ENSP00000300086
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006081cellular aldehyde metabolic process TAS9565553
    GO:0007586digestion TAS9565553
    GO:0008202steroid metabolic process TAS9565553
    GO:0016488farnesol catabolic process IDA--
    GO:0044597daunorubicin metabolic process IMP--


    AKR1B10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AKR1B10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AKR1B10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AKR1B10

    3 DrugBank Compounds for AKR1B10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target--10592235
    3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID-- --target--10592235
    Tolrestat-- 82964-04-3target--10592235

    1 Novoseek chemical compound relationship for AKR1B10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aldose 87.2 31 20460771 (4), 19480738 (3), 14693054 (3), 15329204 (3) (see all 14)

    Search CenterWatch for drugs/clinical trials and news about AKR1B10 / AK1BA 

    Transcripts
    for AKR1B10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AKR1B10 gene: 
    NM_020299.4  

    Unigene Cluster for AKR1B10:

    Aldo-keto reductase family 1, member B10 (aldose reductase)
    Hs.116724  [show with all ESTs]
    Unigene Representative Sequence: AF524864
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359579(uc003vrr.3) ENST00000475559 ENST00000498818 ENST00000496435


    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKR1B10
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AKR1B10
    SwitchGear 3'UTR luciferase reporter plasmid: AKR1B10 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKR1B10 (see all 7)
    OriGene shRNA RFP: AKR1B10
    OriGene siRNA: AKR1B10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKR1B10
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKR1B10 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKR1B10
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: AKR1B10 (NM_020299)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKR1B10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKR1B10 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKR1B10
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AKR1B10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKR1B10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKR1B10

    Additional cDNA sequence: 

    AF044961.1 AF052577.1 AF524864.1 BC008837.2 BT006794.1 CR541801.1 U37100.1 

    14 DOTS entries:

    DT.208348  DT.100783869  DT.100783868  DT.209127  DT.100768987  DT.100028678  DT.121060709  DT.121061103 
    DT.121061153  DT.95268469  DT.97846185  DT.100783870  DT.121060925  DT.121061141 

    24/163 AceView cDNA sequences (see all 163):

    BU175462 BQ224299 BX337599 CR612412 BQ227150 BC008837 CB119917 BE786484 
    BQ430693 BQ231252 NM_020299 CB106637 BQ230079 AI452969 AF052577 BQ949571 
    CB106577 BM783186 CB119937 BQ940536 BQ229376 BU175693 BM837946 CR607509 

    GeneLoc Exon Structure


    Expression
    for AKR1B10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AKR1B10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTTGAATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AKR1B10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Embryoid bodies (Two-step protocol fo...)
    HyStem+BMP4-induced MEL2 cells (HyStem+BMP4 inductio...)Bone
    Human kidney epithelial cell spheroids (Kidney spheroids for...)

    See AKR1B10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AKR1B10

    SOURCE GeneReport for Unigene cluster: Hs.116724

    UniProtKB/Swiss-Prot: AK1BA_HUMAN, O60218
    Tissue specificity: Found in many tissues. Highly expressed in small intestine, colon and adrenal gland

        SABiosciences Custom PCR Arrays for AKR1B10
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKR1B10
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AKR1B10
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKR1B10
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKR1B10
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKR1B10

    Orthologs
    for AKR1B10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AKR1B10 gene from 7/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves AKR1B101 aldo-keto reductase family 1, member B10 (aldose reductase) 71.79(n)
    69.87(a)    		   395338  NM_204629.1  NP_989960.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 74(a)
    73(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 5(14403101-14420033)
    5(14433241-14461213)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkey-180p18.91 si:dkey-180p18.9 68.88(n)
    71.52(a)    		   553452  NM_001077247.1  NP_001070715.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG60843 aldehyde reductase 61(a)
    (best of 7)    		   68C15   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes ARA1(YBR149W)4
    YPR11    		 NADP+ dependent arabinose dehydrogenase, involved in more4
    Ypr1p1    		 51.58(n)1
    45.62(a)1    		   2(539987-541021)4
    8519741  NP_010656.11  8524464 
     NP_009707.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G212501 NAD(P)-linked oxidoreductase domain-containing protein 48.67(n)
    43.6(a)    		   816664  NM_127697.2  NP_179721.1 
    rice
    (Oryza sativa)    		 Liliopsida Os02g01235001 hypothetical protein 49.71(n)
    42.86(a)    		   4328139  NM_001052270.1  NP_001045735.1 


    ENSEMBL Gene Tree for AKR1B10 (if available)
    TreeFam Gene Tree for AKR1B10 (if available) 

    Paralogs
    for AKR1B10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AKR1B10 gene
    AKR1C22  AKR1C32  AKR1CL12  AKR1A12  AKR1E22  AKR1C42  AKR1B152  AKR1B12  
    AKR1D12  AKR1C12  
    11 SIMAP similar genes for AKR1B10 using alignment to 1 protein entry:     AK1BA_HUMAN:
    AKR1B15    AKR1B1    LOC402299    AKR1C1    AKR1E2    AKR1C4
    AKR1CL1    AKR1D1    AKR1A1    AKR1C3    AKR1C2

    AKR1B10 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for AKR1B10
    PGOHUM00000238821 PGOHUM00000235092


    Genomic Variants
    for AKR1B10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/413 NCBI SNPs in AKR1B10 are shown (see all 413)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1823741081,2
    		--134210563(+) ATACTA/CTGCAA 1 -- us2k10--------
    rs6975361,2
    		C,F,--134210587(+) ACTGCG/CTGTCC 1 -- us2k17Minor allele frequency- C:0.19NA WA CSA EA 366
    rs6975351,2
    		C,F,A,--134210616(+) CTTTCA/GTGATT 1 -- us2k16Minor allele frequency- G:0.20NA WA CSA EA 246
    rs1434523231,2
    		--134210623(+) GATTGA/GTCTTT 1 -- us2k10--------
    rs1144823521,2
    		F,--134210647(+) ATTATT/CTCAAA 1 -- us2k11Minor allele frequency- C:0.08WA 118
    rs798534871,2
    		C--134210678(+) TTTTCA/CTTGAA 1 -- us2k10--------
    rs1483688701,2
    		--134210710(+) CCCCAA/GATATA 1 -- us2k10--------
    rs779415371,2
    		--134210779(+) TTTTTC/GTTGTA 1 -- us2k10--------
    rs1888743831,2
    		--134210880(+) GAAAAG/TAAAGT 1 -- us2k10--------
    rs1464065601,2
    		--134210994(+) TATAGC/TGCAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AKR1B10 (134212344 - 134226166 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for AKR1B10: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKR1B10
    DNA2.0 Custom Variant and Variant Library Synthesis for AKR1B10

    Disorders / Diseases
    for AKR1B10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AKR1B10 for disorders           About GeneDecksing

    OMIM gene information: 604707    OMIM disorders: --

    20/27 diseases for AKR1B10 (see all 27):    About MalaCards
    usual interstitial pneumonia    type 2 diabetes mellitus    papillary renal cell carcinoma    barrett's esophagus
    renal cell carcinoma    diabetes mellitus    diabetic cataract    diabetic retinopathy
    diabetic neuropathy    hepatocellular carcinoma    neuropathy    nephropathy
    cataract    medulloblastoma    pneumonia    cervical cancer
    cervicitis    colon cancer    carcinoma    colorectal cancer

    1 Novoseek disease relationship for AKR1B10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 33.8 9 19236911 (2), 14693054 (2), 18056116 (1), 17597105 (1)

    Genetic Association Database (GAD): AKR1B10
    Human Genome Epidemiology (HuGE) Navigator: AKR1B10 (6 documents)

    Export disorders for AKR1B10 gene to outside databases

    Publications
    for AKR1B10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AKR1B10 gene, integrated from 9 sources (see all 79):
    (articles sorted by number of sources associating them with AKR1B10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel human aldose reductase-like gene. (PubMed id 9565553)1, 2, 3, 9 Cao D.... Chung S.S.M. (1998)
    2. Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family. (PubMed id 9765596)1, 2, 3, 9 Hyndman D.J. and Flynn T.G. (1998)
    3. Aldo-keto reductase family 1, member B10 is secreted through a lysosome-mediated non-classical pathway. (PubMed id 21585341)1, 2 Luo D.X.... Cao D. (2011)
    4. Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10. (PubMed id 18087047)1, 2 Gallego O.... Pares X. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Phenotypic heterogeneity and associations of two aldose reductase gene polymorphisms with nephropathy and retinopathy in type 2 diabetes. (PubMed id 12882871)1, 4 Wang Y....Chan J.C. (2003)
    7. [Polymorphism of aldose reductase gene and susceptibility to retinopathy and nephropathy in Caucasians with type 1 diabetes] (PubMed id 12365083)1, 4 Fanelli A....Marre M. (2002)
    8. Analysis of the association between diabetic nephropathy and polymorphisms in the aldose reductase gene in Type 1 and Type 2 diabetes mellitus. (PubMed id 11703436)1, 4 Neamat-Allah M....Cox A. (2001)
    9. New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma. (PubMed id 9537432)1, 2 Scuric Z.... Hwang J.-J. (1998)
    10. Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention. (PubMed id 17597105)1, 9 Yan R....Cao D. (2007)

    External Searches for AKR1B10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing AKR1B10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57016 HGNC: 382 AceView: AKR1B10 Ensembl:ENSG00000198074 euGenes: HUgn57016
    ECgene: AKR1B10 Kegg: 57016 H-InvDB: AKR1B10

    Other Databases showing AKR1B10 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AKR1B10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AKR1B10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AKR1B10 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for AKR1B10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AKR1B10 gene:
    Search GeneIP for patents involving AKR1B10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for AKR1B10 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for AKR1B10 (Aldo-keto Reductase 1B10/AKR1B10)  
     OriGene Antibodies for AKR1B10   OriGene shRNA RFP for AKR1B10  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKR1B10   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKR1B10  
     OriGene Protein Over-expression Lysate for AKR1B10   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for AKR1B10   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKR1B10   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKR1B10  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for AKR1B10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AKR1B10   OriGene Custom Protein Services for AKR1B10  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AKR1B10
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKR1B10
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKR1B10
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKR1B10
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKR1B10
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKR1B10
     GenScript Custom Purified and Recombinant Proteins Services for AKR1B10 GenScript cDNA clones with any tag delivered in your preferred vector for AKR1B10
     GenScript Custom Assay Services for AKR1B10 GenScript Custom Superior Antibodies Services for AKR1B10
     GenScript Custom overexpressing Cell Line Services for AKR1B10 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in AKR1B10 promoter
     Search Chromatin IP Primers for AKR1B10
     RT2 qPCR Primer Assay in human, mouse, rat AKR1B10
     GNC Network for AKR1B10
     SABiosciences Custom PCR Arrays for AKR1B10
     Search Tocris compounds for AKR1B10
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AKR1B10 antibodies
     AKR1B10 proteins
     AKR1B10 lysates
     Antibodies for AKR1B10
     See all of Abcam's Antibodies, Kits and Proteins for AKR1B10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for AKR1B10




     AKR1B10 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for AKR1B10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKR1B10
     SwitchGear 3'UTR luciferase reporter plasmids for AKR1B10
     SwitchGear Promoter luciferase reporter plasmids for AKR1B10
     ThermoFisher Antibody for AKR1B10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKR1B10
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      AKR1B10 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4