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AKR1B10 Gene

protein-coding GIFtS: 66

GC07P133862

aldo-keto reductase family 1, member B10 (aldose reductase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: AKR1B11)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
AKR1B11 ^², ³
AKR1B12 ^¹, ²
ALDRLn ^¹, ²
ARL-1 ^¹, ², ³
ARL1 ^¹, ²
ARP ^³
EC 1.1.1.- ^³
HIS ^¹, ²
HSI ^¹, ²
MGC14103 ^²
hARP ^³

Descriptions
Aldose reductase-like ^³
Aldose reductase-related protein ^², ³
SI reductase ^³
Small intestine reductase ^², ³
aldo-keto reductase family 1, member B10 ^²
aldo-keto reductase family 1, member B10 (aldose reductase) ^²
aldo-keto reductase family 1, member B11 (aldose reductase-like) ^²
aldose reductase-like 1 ^²
aldose reductase-like peptide ^²

External Ids
HGNC: 382¹
Entrez Gene: 57016²
UniProtKB: O60218³
Ensembl: ENSG00000198074⁷

Search outside databases for aliases for AKR1B10 gene

Previous GC identifers: GC07P132555 GC07P133614 GC07P133628 GC07P133669

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AKR1B10:

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40

known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes,

and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and

colon, and may play an important role in liver carcinogenesis. [provided by RefSeq]

UniProtKB/Swiss-Prot: AK1BA_HUMAN, O60218

Function: Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic

aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of

reactive aldehydes in the digested food before the nutrients are passed on to other organs

Gene Wiki entry for AKR1B10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AKR1B10 gene

Entrez Gene cytogenetic band: 7q33 Ensembl cytogenetic band: 7q33 HGNC cytogenetic band: 7q33

AKR1B10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P133862: (about GC identifiers)

Start:	133,862,884 bp from pter
End:	133,876,700 bp from pter
Size:	13,817 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 133,556,718-133,570,477

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AK1BA_HUMAN, O60218 (See protein sequence)

Recommended Name: Aldo-keto reductase family 1 member B10

Size: 316 amino acids; 36021 Da

Subcellular location: Cytoplasm (Probable)

PDB structures from and Proteopedia :

1ZUA (3D)

Secondary accessions: A4D1P1 O75890 Q6FHF3 Q8IWZ1

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_064695.3

ENSEMBL proteins:

ENSP00000352584

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AKR1B10)
	Human Recombinant Proteins from Abnova (AKR1B10)

OriGene Purified Recombinant Human Protein: AKR1B10

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for AKR1B10:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AKR1B10
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (AKR1B10), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AKR1B10)
	Novus Biologicals Antibodies for AKR1B10

Assays for AKR1B10:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O60218

ProtoNet protein and cluster: O60218

1 Blocks protein family: IPB001395 Aldo/keto reductase

UniProtKB/Swiss-Prot: AK1BA_HUMAN, O60218

Similarity: Belongs to the aldo/keto reductase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AKR1B10)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AKR1B10)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020299

Applied Biosystems Silencer® siRNAs for AKR1B10

Sigma-Aldrich siRNA and siRNA Panels for AKR1B10

Sigma-Aldrich shRNA for AKR1B10

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AKR1B10
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_020299
Myc/DDK tagged cDNA clone in CMV expression vector: NM_020299
untagged cDNA clone in CMV expression vector: NM_020299

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_020299

UniProtKB/Swiss-Prot: AK1BA_HUMAN, O60218

Function: Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic

aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of

reactive aldehydes in the digested food before the nutrients are passed on to other organs

Enzyme regulation: Inhibited by tolrestat

Biophysicochemical properties: Kinetic parameters: KM=600 uM for D,L-glyceraldehyde; KM=0.6 uM for

all-trans-retinaldehyde; KM=0.7 uM for 9-cis-retinaldehyde;

Enzyme Number (IUBMB): EC 1.1.1.-

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004033	aldo-keto reductase activity	TAS	9565553
GO:0005515	protein binding	IPI	18056116
GO:0016491	oxidoreductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for AKR1B10 (Your Favorite Gene powered by Ingenuity)

Galactose Metabolism
Pyruvate Metabolism
Pentose and Glucuronate Interconversions
Glycerolipid Metabolism
Fructose and Mannose Metabolism

GeneDecks AKR1B10 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for AKR1B10

5/29 Interacting proteins for AKR1B10 (O60218¹ ENSP00000352584³) via UniProtKB, MINT, and/or STRING (see all 29 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACACA	Q13085¹	EBI-1572139, EBI-717681
AOC2	ENSP00000253799³	STRING (score=.913)
AADAT	ENSP00000336808³	STRING (score=.899)
ABP1	ENSP00000373621³	STRING (score=.899)
ACAA1	ENSP00000333664³	STRING (score=.899)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006081	cellular aldehyde metabolic process	TAS	9565553
GO:0007586	digestion	TAS	9565553
GO:0008202	steroid metabolic process	TAS	9565553
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for AKR1B10

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AKR1B10
1 Novoseek chemical compound relationship for AKR1B10 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
aldose	85.80	17	14693054 (3), 15329204 (3), 17329238 (2), 14768008 (1) (see all 9)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AKR1B10)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AKR1B10)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020299

Sigma-Aldrich siRNA and siRNA Panels for AKR1B10

Sigma-Aldrich shRNA for AKR1B10

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_020299

REFSEQ mRNAs for AKR1B10 gene:

NM_020299.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_020299

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020299
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020299
                                 untagged cDNA clone in CMV expression vector: NM_020299

Additional cDNA sequence:

AF044961.1 AF052577.1 AF524864.1 BC008837.2 BC072676.1 BT006794.1 CR541801.1 CR607509.1

CR612412.1 U37100.1

15 DOTS entries:

DT.208348 DT.100783869 DT.100783868 DT.100768987 DT.209127 DT.100028678 DT.121060709 DT.92430986

DT.100783870 DT.121061103 DT.121061153 DT.97846185 DT.121060925 DT.121061141 DT.95268469

24/163 AceView cDNA sequences (see all 163 ):

CB120598 CB119937 BU168299 BU164592 BQ231252 BQ224299 BQ430693 CB106577

BX337599 BU175693 BQ940536 CR612412 AI452969 BM783186 NM_020299 BE786484

BQ949452 CR607509 CB106637 BQ227150 BQ224413 CB119917 BQ230079 BC072676

highest scoring ESTs for AKR1B10:

U37100 AA804597 AA947514 AF044961 AF052577 AF524864 AI270664 AI291463 AI292337 AI301329

Unigene Cluster for AKR1B10:

Aldo-keto reductase family 1, member B10 (aldose reductase)

Hs.116724 [show with all ESTs]

Unigene Representative Sequence: BC072676

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000359579

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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AKR1B10 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AKR1B10

¹ / ² / ³

3 probe-sets matching AKR1B10 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37482_at²^{, 3}	U95-A	4	1.00	0.84	1.00	1.00	U37100	1.00	1.00	1.00	1
206561_s_at²^{, 3}	U133-A	5	1.00	0.59	--	--	NM_020299	0.60	1.00	0.82	1
206561_s_at²	U133Plus2	5	1.00	0.59	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCTTGAATAA

SOURCE GeneReport for Unigene cluster: Hs.116724
Expression variation in blood from EXPOLDB for AKR1B10
UniProtKB/Swiss-Prot: AK1BA_HUMAN, O60218
Tissue specificity: Found in many tissues. Highly expressed in small intestine, colon and adrenal
gland

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AKR1B10 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	AKR1B10¹	--	aldo-keto reductase family 1, member B10 (aldose reductase)	99.16(n) 99.37(a)	463867 XM_001140104.1 XP_001140104.1
cow (Bos taurus)	AKR1B10¹	--	aldo-keto reductase family 1, member B10 (aldose reductase)	84.05(n) 79.14(a)	525193 XM_603541.3 XP_603541.3
rat (Rattus norvegicus)	Akr1b10¹	--	aldo-keto reductase family 1, member B10 (aldose reductase)	82.81(n) 82.59(a)	296972 NM_001013084.1 NP_001013102.1
mouse (Mus musculus)	Akr1b8⁵ 2310005E10Rik¹	6 (13.00 cM)⁵	aldo-keto reductase family 1, member B8⁵ RIKEN cDNA 2310005E10 gene¹	82.07(n)¹ 82.91(a)¹	67861¹ NM_172398.3¹ NP_765986.3¹ AK207771⁵ AU019003⁵ (see all 8)
chicken (Gallus gallus)	AKR1B10¹	--	aldo-keto reductase family 1, member B10 (aldose reductase)	71.69(n) 69.55(a)	395338 NM_204629.1 NP_989960.1

About this table Species with no ortholog for AKR1B10

ENSEMBL Gene Tree for AKR1B10

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AKR1B10 gene

AKR1CL2² AKR1B1² AKR1A1²

Pseudogenes

2 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/126 NCBI SNPs in AKR1B10 are shown (see all 126 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 38)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs706184^1,2	A,C,F,H,O	133862190(+)	`GACTCC/TATTTC`	1	--	ng5¹		7		EU EA WA NA	562
--	rs782510^1,2	A,F,H,O	133861848(+)	`CATAGG/TTGCAA`	1	--	ng5¹		2		EU WA	240
--	rs10236737^1,2	A,C,F,H	133862578(+)	`gccagA/Gcttct`	1	--	ng5¹		4		EU EA WA	406
--	rs2037004^1,2	A,C,F,H	133863151(+)	`ACAGAG/AAGCAG`	1	--	ut5¹ ese³		7		EU EA WA NA	554
	rs3735042^1,2	C,F,H	133874258(+)	`GGAGAT/CGGCAA`	1	T/M	mis¹		9		EA EU WA	2304
	rs4728329^1,2	C,F,H	133876367(+)	`CCTTCG/AATGCA`	1	N/D	mis¹ ese³		4		EU EA WA	398
--	rs706186^1,2	A,C	133861943(+)	`CTCATA/CAACAA`	1	--	ng5¹		0	--	--	--	--
--	rs706185^1,2	A,C	133862009(+)	`CGTGGA/CCCTGG`	1	--	ng5¹		0	--	--	--	--
--	rs2303312^1,2	F,H	133867224(+)	`AGAGAC/TCCCTT`	1	P/S	mis¹		5		EA EU WA	1720
--	rs706183^1,2	A,C	133862283(+)	`ctttcC/Tttcct`	1	--	ng5¹ trp³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for AKR1B10 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604707

1 Novoseek disease relationship for AKR1B10 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatocellular carcinoma	40.96	9	19236911 (2), 14693054 (2), 18056116 (1), 17597105 (1)

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1 PharmGKB disease relationship for AKR1B10 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Carcinoma, Non-Small-Cell Lung	FA	15755999

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Genetic Association Database: AKR1B10
Human Genome Epidemiology Navigator: AKR1B10 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/47 PubMed articles for AKR1B10 gene (see all 47 ):

Identification and characterization of a novel human aldose reductase-like gene. (PubMed id 9565553)^{1, 2, 3, 4} Cao D....Chung S.S. (1998)
Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family. (PubMed id 9765596)^{1, 2, 3, 4} Hyndman D.J. and Flynn T.G. (1998)
Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10. (PubMed id 18087047)^{3, 4} Gallego O....Pares X. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Phenotypic heterogeneity and associations of two aldose reductase gene polymorphisms with nephropathy and retinopathy in type 2 diabetes. (PubMed id 12882871)^{3, 6} Wang Y....Chan J.C. (2003)
[Polymorphism of aldose reductase gene and susceptibility to retinopathy and nephropathy in Caucasians with type 1 diabetes] (PubMed id 12365083)^{3, 6} Fanelli A....Marre M. (2002)
Analysis of the association between diabetic nephropathy and polymorphisms in the aldose reductase gene in Type 1 and Type 2 diabetes mellitus. (PubMed id 11703436)^{3, 6} Neamat-Allah M....Cox A. (2001)
New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma. (PubMed id 9537432)^{3, 4} Scuric Z.... Hwang J.-J. (1998)
Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention. (PubMed id 17597105)^{1, 3} Yan R....Cao D. (2007)
Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells. (PubMed id 18056116)^{1, 3} Ma J....Cao D. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 57016	HGNC: 382	AceView: AKR1B10	Ensembl:ENSG00000198074	euGenes: HUgn57016
ECgene: AKR1B10	H-InvDB: AKR1B10

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for AKR1B10	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for AKR1B10
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for AKR1B10:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AKR1B10-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AKR1B10		Antibodies for AKR1B10
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AKR1B10		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Antibodies (AKR1B10)

	Tagged/untagged cDNA clones
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	Purified proteins from HEK293T cells
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	shRNA in GFP-retroviral vector

Search Tocris compounds for AKR1B10

	Drugs for AKR1B10
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for AKR1B10

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AKR1B10 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for AKR1B10

Summaries
for AKR1B10

Genomic Location
for AKR1B10

Proteins
for AKR1B10

Protein Domains/
Families
for AKR1B10

Gene Function
for AKR1B10

Pathways & Interactions
for AKR1B10

Drugs & Compounds
for AKR1B10

Transcripts
for AKR1B10

Expression
for AKR1B10

Orthologs
for AKR1B10

Paralogs
for AKR1B10

SNPs/Variants
for AKR1B10

Disorders & Mutations
for AKR1B10

Medical News
for AKR1B10

Publications
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AKR1B10 (Gene Symbol)
AKR1B11
AKR1B12
ALDRLn
ARL-1
ARL1
ARP
EC 1.1.1.-
HIS
HSI
MGC14103
hARP
Aldose reductase-like
Aldose reductase-related protein
SI reductase
Small intestine reductase
aldo-keto reductase family 1, member B10
aldo-keto reductase family 1, member B10 (aldose reductase)
aldo-keto reductase family 1, member B11 (aldose reductase-like)
aldose reductase-like 1
aldose reductase-like peptide

AKR1B10 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor AKR1B10

Summariesfor AKR1B10

Genomic Locationfor AKR1B10

Proteinsfor AKR1B10

Protein Domains/Familiesfor AKR1B10

Gene Functionfor AKR1B10

Pathways & Interactionsfor AKR1B10

Drugs & Compoundsfor AKR1B10

Transcriptsfor AKR1B10

Expression for AKR1B10

Orthologsfor AKR1B10

Paralogsfor AKR1B10

SNPs/Variantsfor AKR1B10

Disorders & Mutationsfor AKR1B10

Medical Newsfor AKR1B10

Publicationsfor AKR1B10

Search for AKR1B10

Genome Databases showing AKR1B10

Other Databases showing AKR1B10

Specialized Databases showing AKR1B10

Licensable Technologiesfor AKR1B10

Servicesfor AKR1B10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AKR1B10

Summaries
for AKR1B10

Genomic Location
for AKR1B10

Proteins
for AKR1B10

Protein Domains/
Families
for AKR1B10

Gene Function
for AKR1B10

Pathways & Interactions
for AKR1B10

Drugs & Compounds
for AKR1B10

Transcripts
for AKR1B10

Expression
for AKR1B10

Orthologs
for AKR1B10

Paralogs
for AKR1B10

SNPs/Variants
for AKR1B10

Disorders & Mutations
for AKR1B10

Medical News
for AKR1B10

Publications
for AKR1B10

Licensable Technologies
for AKR1B10

Services
for AKR1B10