Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AKR1B1 Gene

protein-coding   GIFtS: 75
GCID: GC07M134127

Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase)


(Previous symbol: ALDR1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase)1 2     Aldehyde Reductase 12
ALDR11 2 3 5     Aldose Reductase2
Aldo-Keto Reductase Family 1 Member B12 3     Lii5-2 CTCL Tumor Antigen2
AR2 3     Low Km Aldose Reductase2
EC 1.1.1.213 8     Aldehyde Reductase3
ADR2     EC 1.1.18
ALR22     

External Ids:    HGNC: 3811   Entrez Gene: 2312   Ensembl: ENSG000000856627   OMIM: 1038805   UniProtKB: P151213   

Export aliases for AKR1B1 gene to outside databases

Previous GC identifers: GC07M132469 GC07M133529 GC07M133543 GC07M133346 GC07M133584 GC07M133778 GC07M128428


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for AKR1B1 Gene:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes
and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of
glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of
glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the
HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that
used by the Mouse Genome Informatics database. (provided by RefSeq, Feb 2009)

GeneCards Summary for AKR1B1 Gene:
AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)) is a protein-coding gene. Diseases associated with AKR1B1 include diabetic polyneuropathy, and diabetic cataract. GO annotations related to this gene include electron carrier activity and alditol:NADP+ 1-oxidoreductase activity. An important paralog of this gene is AKR1C2.

UniProtKB/Swiss-Prot: ALDR_HUMAN, P15121
Function: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their
corresponding alcohols with a broad range of catalytic efficiencies

summary for AKR1B1 Gene:
Aldose reductase (also known as aldehyde reductase) catalyzes the reduction of a wide variety of hydrophobic
and hydrophilic carbonyl-containing compounds to their corresponding alcohols. This enzyme is cytosolic,
exists as a monomer and requires NADPH as a co-factor. Aldose reductase catalyzes the rate-limiting step of
the polyol pathway (the conversion of glucose to sorbitol), a pathway that is overactive in diabetes
mellitus and the cause of diabetic complications. Aldose reductase is expressed in most mammalian tissues
and is found at high concentrations in the seminal vesicles, lens, retina, renal medulla and sciatic nerve.
Currently there is much interest in the development of pharmalogical inhibitors targeting this enzyme as a
method of preventing the complications associated with chronic hyperglycemia.

Gene Wiki entry for AKR1B1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AKR1B1 gene promoter:
         GR   AP-1   ATF-2   GR-beta   STAT5A   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAKR1B1 promoter sequence
   Search Chromatin IP Primers for AKR1B1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKR1B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q35

AKR1B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKR1B1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M134127:  view genomic region     (about GC identifiers)

Start:
134,127,102 bp from pter      End:
134,144,036 bp from pter
Size:
16,935 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 133,471,421-133,488,201     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ALDR_HUMAN, P15121 (See protein sequence)
Recommended Name: Aldose reductase  
Size: 316 amino acids; 35853 Da
Subunit: Monomer
Selected PDB 3D structures from and Proteopedia for AKR1B1 (see all 113):
1ABN (3D)        1ADS (3D)        1AZ1 (3D)        1AZ2 (3D)        1EF3 (3D)        1EL3 (3D)    
Secondary accessions: B2R8N3 Q5U031 Q6FGA4 Q6ICP2 Q9BS21 Q9UCI9

Explore the universe of human proteins at neXtProt for AKR1B1: NX_P15121

Explore proteomics data for AKR1B1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys12, Lys86, Lys222, Lys243, Lys263
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for AKR1B1 (P15121) (see all 13)
     IPKSVTP  GLGTWKS  DLKLDYLD  LFIVSKLW 


    See AKR1B1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001619.1  
    ENSEMBL proteins: 
     ENSP00000285930   ENSP00000414399   ENSP00000413205  
    Reactome Protein details: P15121

    AKR1B1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for AKR1B1
    OriGene Protein Over-expression Lysate for AKR1B1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for AKR1B1
    GenScript Custom Purified and Recombinant Proteins Services for AKR1B1
    Novus Biologicals AKR1B1 Proteins
    Novus Biologicals AKR1B1 Lysates
    Sino Biological Recombinant Protein for AKR1B1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for AKR1B1
    Cloud-Clone Corp. Proteins for AKR1B1

    AKR1B1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of AKR1B1
    Browse R&D Systems for Antibodies
    OriGene Antibodies for AKR1B1
    OriGene Custom Antibody Services for AKR1B1
    Novus Biologicals AKR1B1 Antibodies
    Abcam antibodies for AKR1B1
    Cloud-Clone Corp. Antibodies for AKR1B1
    ThermoFisher Antibody for AKR1B1
    LSBio Antibodies in human, mouse, rat for AKR1B1

    AKR1B1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AKR1B1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AKR1B1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AKR1B1
    Cloud-Clone Corp. CLIAs for AKR1B1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    AKR: Aldo-keto reductases

    4 InterPro protein domains:
     IPR001395 Aldo/ket_red
     IPR018170 Aldo/ket_reductase_CS
     IPR020471 Aldo/keto_reductase_subgr
     IPR023210 NADP_OxRdtase_dom

    Graphical View of Domain Structure for InterPro Entry P15121

    ProtoNet protein and cluster: P15121

    1 Blocks protein domain: IPB001395 Aldo/keto reductase

    UniProtKB/Swiss-Prot: ALDR_HUMAN, P15121
    Similarity: Belongs to the aldo/keto reductase family


    AKR1B1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALDR_HUMAN, P15121
    Function: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their
    corresponding alcohols with a broad range of catalytic efficiencies
    Catalytic activity: Alditol + NAD(P)(+) = aldose + NAD(P)H
    Enzyme regulation: Cys-299 may regulate the kinetic and inhibition properties of the enzyme, but does not
    participate in catalysis

         Genatlas biochemistry entry for AKR1B1:
    aldo-keto reductase family 1 member B1,monomeric NADPH dependent,widely expressed,at low levels in liver,cytosolic
    reducing aromatic and aliphatic aldehydes,with less activity than AKR1A1

         Enzyme Numbers (IUBMB): EC 1.1.1.211 2 EC 1.1.12

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004032alditol:NADP+ 1-oxidoreductase activity IEA--
    GO:0004033aldo-keto reductase (NADP) activity TAS8435445
    GO:0009055electron carrier activity TAS2112546
    GO:0016491oxidoreductase activity ----
    GO:0043795glyceraldehyde oxidoreductase activity IDA--
         
    AKR1B1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AKR1B1:
     Upregulation of Wnt/beta-caten 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Akr1b3):
     behavior/neurological  growth/size/body  homeostasis/metabolism  mortality/aging  renal/urinary system 
     skeleton  vision/eye 

    AKR1B1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for AKR1B1: Akr1b3tm1Tona Akr1b3tm1Skc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AKR1B1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AKR1B1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AKR1B1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AKR1B1

    miRNA
    Products:
        
    miRTarBase miRNAs that target AKR1B1:
    hsa-mir-34a-5p (MIRT025547), hsa-mir-342-5p (MIRT038212), hsa-mir-1226-3p (MIRT036537)

    Block miRNA regulation of human, mouse, rat AKR1B1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate AKR1B1:
    hsa-miR-1304
    SwitchGear 3'UTR luciferase reporter plasmidAKR1B1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AKR1B1
    Predesigned siRNA for gene silencing in human, mouse, rat AKR1B1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AKR1B1

    Clone
    Products:
         
    OriGene clones in human, mouse for AKR1B1 (see all 8)
    OriGene ORF clones in mouse, rat for AKR1B1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AKR1B1 (NM_001628)
    Sino Biological Human cDNA Clone for AKR1B1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKR1B1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKR1B1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AKR1B1
    Browse ESI BIO Cell Lines and PureStem Progenitors for AKR1B1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKR1B1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ALDR_HUMAN, P15121: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular4
    nucleus4
    cytoskeleton2
    mitochondrion2
    plasma membrane2
    vacuole2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS2112546
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    AKR1B1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for AKR1B1 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    2Fructose and mannose metabolism
    Polyol pathway0.00
    Fructose and mannose metabolism
    3acetone degradation I (to methylglyoxal)
    acetone degradation I (to methylglyoxal)0.44
    methylglyoxal degradation III0.00
    4Metabolism of steroid hormones and vitamin D
    Pregnenolone biosynthesis0.00
    Metabolism of steroid hormones and vitamin D
    5Cyclophosphamide Pathway, Pharmacodynamics
    Cyclophosphamide Pathway, Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AKR1B1
        Androgen Signaling
    Akt Signaling

    1 GeneGo (Thomson Reuters) Pathway for AKR1B1
        Naphthalene metabolism

    4 BioSystems Pathways for AKR1B1
        Polyol pathway
    methylglyoxal degradation III
    acetone degradation I (to methylglyoxal)
    metapathway biotransformation


    1 Reactome Pathway for AKR1B1
        Pregnenolone biosynthesis

    2 PharmGKB Pathways for AKR1B1
        Cyclophosphamide Pathway, Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for AKR1B1) (see all 6):
        Pentose and glucuronate interconversions
    Fructose and mannose metabolism
    Galactose metabolism
    Glycerolipid metabolism
    Pyruvate metabolism


    AKR1B1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AKR1B1: 
              Stress & Toxicity PathwayFinder in human mouse rat
              Osmotic Stress in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AKR1B1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AKR1B1 (P151212, 3 ENSP000002859304) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1Q157972, 3MINT-62012 I2D: score=3 
    PRMT2P553452, 3, ENSP000003479064MINT-8290942 MINT-8291016 I2D: score=1 STRING: ENSP00000347906
    GOT1P171743, ENSP000003595394I2D: score=1 STRING: ENSP00000359539
    PAX7P237593, ENSP000003645244I2D: score=1 STRING: ENSP00000364524
    DSTQ030013, ENSP000003597904I2D: score=1 STRING: ENSP00000359790
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS2112546
    GO:0006700C21-steroid hormone biosynthetic process TAS--
    GO:0006950response to stress TAS8435445
    GO:0008202steroid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    AKR1B1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for AKR1B1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AlrestatinAldose reductase inhibitor[51411-04-2]
    EBPCAldose reductase inhibitor[4450-98-0]

    Selected HMDB Compounds for AKR1B1 (see all 18)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (S)-Propane-1,2-diol(2S)-propane-1,2-diol (see all 3)4254-15-3--
    Alpha-D-GlucoseHexopyranose (see all 11)492-62-6--
    D-Galactose(+)-Galactose (see all 14)59-23-4--
    D-Lactaldehyde(2R)-2-hydroxypropanal (see all 4)3946-09-6--
    D-XylitolD-Xylitol (see all 20)87-99-0--
    D-Xylosed-Xylose (see all 8)58-86-6--
    GalactitolDulcose (see all 13)608-66-2--
    Glyceraldehyde(+/-)-2,3-dihydroxy-Propanal (see all 24)56-82-6--
    Glycerol1,2,3-Trihydroxypropane (see all 22)56-81-5--
    L-ArabinoseArabinose (see all 3)5328-37-0--

    Selected DrugBank Compounds for AKR1B1 (see all 29)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sulindac-- 38194-50-2targetinhibitor8529171 3920599 6409111 2632448 11752352 6413448
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target--17139284 17016423 10592235
    Alrestatin-- 51411-04-2target--17139284 17016423 10592235
    IDD552-- --target--17139284 17016423 10592235
    Inhibitor Idd 384-- --target--17139284 17016423 10592235
    N-Acetylalanine-- 97-69-8target--17139284 17016423 10592235
    [3-(4-Bromo-2-Fluoro-Benzyl)-7-Chloro-2,4-Dioxo-3,4-Dihydro-2h-Quinazolin-1-Yl]-Acetic Acid-- --target--17139284 17016423 10592235
    Alpha-D-Glucose-6-Phosphate-- --target--17139284 17016423
    Citric Acid-- 77-92-9target--17139284 17016423
    Fidarestat(Stereoisomer)-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for AKR1B1 gene (see all 122)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aldose 99.5 2542 1901806 (10), 15736047 (10), 7748183 (9), 15746188 (9) (see all 99)
    tolrestat 95.8 56 2119323 (3), 12604217 (2), 9871575 (2), 9186297 (2) (see all 47)
    epalrestat 95.4 81 18644069 (3), 9681489 (2), 12200074 (2), 7585850 (2) (see all 48)
    sorbinil 95 67 2157439 (3), 2122961 (2), 1472112 (2), 1907924 (2) (see all 50)
    zopolrestat 92.6 32 17898287 (3), 7929871 (2), 15530506 (2), 10737739 (2) (see all 21)
    ponalrestat 92.4 50 10226565 (3), 1902410 (2), 1611835 (2), 10628361 (2) (see all 28)
    fidarestat 91.6 38 19594152 (4), 10882376 (4), 10706394 (3), 11359994 (3) (see all 18)
    ranirestat 91 14 19212096 (2), 18363521 (2), 17593238 (1), 16373898 (1) (see all 7)
    alrestatin 89.9 14 8003482 (2), 9405046 (2), 2157439 (2), 11461193 (1) (see all 7)
    mannitol 89.2 290 14583178 (6), 15967436 (5), 1901456 (4), 1936586 (4) (see all 99)



    AKR1B1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AKR1B1 gene: 
    NM_001628.2  

    Unigene Cluster for AKR1B1:

    Aldo-keto reductase family 1, member B1 (aldose reductase)
    Hs.521212  [show with all ESTs]
    Unigene Representative Sequence: AB209796
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285930(uc003vrp.1) ENST00000434222 ENST00000465351 ENST00000467251
    ENST00000498771 ENST00000498373 ENST00000487438 ENST00000489022 ENST00000491741
    ENST00000497983 ENST00000484592 ENST00000467829 ENST00000426422 ENST00000462784


    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AKR1B1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate AKR1B1:
    hsa-miR-1304
    SwitchGear 3'UTR luciferase reporter plasmidAKR1B1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AKR1B1
    Predesigned siRNA for gene silencing in human, mouse, rat AKR1B1
    Clone
    Products:
         
    OriGene clones in human, mouse for AKR1B1 (see all 8)
    OriGene ORF clones in mouse, rat for AKR1B1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AKR1B1 (NM_001628)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKR1B1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKR1B1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AKR1B1
    OriGene qSTAR qPCR primer pairs in human, mouse for AKR1B1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AKR1B1
      QuantiTect SYBR Green Assays in human, mouse, rat AKR1B1
      QuantiFast Probe-based Assays in human, mouse, rat AKR1B1

    Additional mRNA sequence: 

    AB209796.1 AF328729.1 AK311339.1 AK313439.1 BC000260.1 BC005387.1 BC010391.1 BT019859.1 
    CR450351.1 CR542203.1 J04795.1 J05017.1 J05474.1 M34720.1 X15414.1 

    Selected DOTS entries (see all 50):

    DT.91938612  DT.100637594  DT.91911063  DT.95182901  DT.95182930  DT.448405  DT.121060998  DT.95197736 
    DT.100709235  DT.121061101  DT.121060563  DT.40259704  DT.92466151  DT.121060534  DT.121060712  DT.219759 
    DT.100851794  DT.95182925  DT.121061093  DT.95182906  DT.100674627  DT.100728479  DT.121060798  DT.121439753 

    Selected AceView cDNA sequences (see all 899):

    CB125532 BX280797 F04333 AA340838 CR600539 BQ686205 CA431457 AU142675 
    BM697976 BQ227284 CR620415 AW673974 BG749355 BQ933992 CR592719 AI190044 
    R71257 AL695815 BG168787 CD518304 AI075417 BM990258 CR593981 AA379560 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AKR1B1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a ·
    SP1:                                                  -                       -     -                 -     -                                         -         
    SP2:                                                  -                       -     -                 -     -                                                   
    SP3:                                -     -     -     -                       -     -                 -     -                                                   
    SP4:                                                  -                       -     -                 -     -     -     -     -                       -         
    SP5:                                                  -                 -     -     -     -     -     -     -     -     -                             -         

    ExUns: 10b · 10c ^ 11 ^ 12a · 12b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for AKR1B1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AKR1B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAGTTTTG
    AKR1B1 Expression
    About this image


    AKR1B1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Lower Urinary Tract (Urinary System)
             Ureter
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    AKR1B1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKR1B1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.521212

    UniProtKB/Swiss-Prot: ALDR_HUMAN, P15121
    Tissue specificity: Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AKR1B1: 
              Stress & Toxicity PathwayFinder in human mouse rat
              Osmotic Stress in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AKR1B1
    OriGene qSTAR qPCR primer pairs in human, mouse for AKR1B1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AKR1B1
    QuantiTect SYBR Green Assays in human, mouse, rat AKR1B1
    QuantiFast Probe-based Assays in human, mouse, rat AKR1B1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKR1B1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AKR1B1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akr1b31 , 5 aldo-keto reductase family 1, member B3 (aldose reductase)1, 5 85.93(n)1
    85.71(a)1
      6 (14.87 cM)5
    116771  NM_009658.31  NP_033788.31 
     343039345 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686092 hypothetical protein MGC68609 76.81(n)    BC060383.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.61422 Transcribed sequence with moderate similarity to protein more 77.16(n)    CK029623.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60843 aldehyde reductase 60(a)
    (best of 7)
      68C15   --
    rice
    (Oryza sativa)
    Liliopsida NM_190596.12   -- 74.95(n)    NM_190596.1 


    ENSEMBL Gene Tree for AKR1B1 (if available)
    TreeFam Gene Tree for AKR1B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for AKR1B1 gene
    AKR1C22  AKR1CL12  AKR1C32  AKR1B102  AKR1A12  AKR1C42  AKR1E22  AKR1B152  
    AKR1D12  AKR1C12  
    11 SIMAP similar genes for AKR1B1 using alignment to 3 protein entries:     ALDR_HUMAN (see all proteins):
    AKR1B10    AKR1B15    AKR1C1    AKR1C3    AKR1CL1    AKR1C4
    AKR1E2    AKR1C2    AKR1A1    LOC402299    AKR1D1

    AKR1B1 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for AKR1B1 (see all 9)
    PGOHUM00000242177 PGOHUM00000248391 PGOHUM00000247814 PGOHUM00000234983 PGOHUM00000234282


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for AKR1B1 (see all 520)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1393908931,2
    --134126681(+) AACACC/TGACCT 1 -- ds50010--------
    rs1500570281,2
    --134126683(+) CACCGA/TCCTCG 1 -- ds50010--------
    rs1444056311,2
    --134126698(+) TCATAC/TGTAGA 1 -- ds50010--------
    rs737249571,2
    C,F--134126731(+) GAATCG/AAACAT 1 -- ds50012Minor allele frequency- A:0.04WA 120
    rs171678511,2
    C,F--134127061(+) TGAGAT/CAGAAG 1 -- ds50019Minor allele frequency- C:0.33NA WA 388
    rs1837870481,2
    C--134127205(+) TTTGAC/GCTGGT 1 -- ut310--------
    rs22295431,2
    C,F,O,A,H--134127355(-) GCCAGC/AGAGGG 1 -- ut31 ese312Minor allele frequency- A:0.10MN NA EA NS 930
    rs1862968541,2
    --134127382(+) GTCCCA/GCTGCT 1 -- ut310--------
    rs50551,2
    F--134127402(-) TAGTAT/GGGCCT 1 -- ut31 ese31Minor allele frequency- G:0.05MN 80
    rs2015934661,2
    --134127452(+) AGGTCA/GCTTGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for AKR1B1 (134127102 - 134144036 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for AKR1B1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv889222CNV Gain21882294

    Human Gene Mutation Database (HGMD): AKR1B1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AKR1B1
    DNA2.0 Custom Variant and Variant Library Synthesis for AKR1B1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 103880    OMIM disorders: --

    Selected diseases for AKR1B1 (see all 68):    
    About MalaCards
    diabetic polyneuropathy    diabetic cataract    diabetic neuropathy    diabetic autonomic neuropathy
    polyradiculopathy    hyperglycemia    diabetic nephropathy    diabetic macular edema
    polyneuropathy    corneal disease    autonomic neuropathy    galactosemia
    cataract-glaucoma    type 1 diabetes mellitus    diabetes mellitus    diabetic retinopathy
    senile cataract    gastroparesis    cholecystitis    bladder transitional cell carcinoma

    10 diseases from the University of Copenhagen DISEASES database for AKR1B1:
    Diabetes mellitus     Diabetic cataract     Neuropathy     Diabetic retinopathy
    Hyperglycemia     Galactosemia     Hepatitis B     Autonomic neuropathy
    Blindness     Polyneuropathy

    AKR1B1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for AKR1B1 gene (see all 67)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetic neuropathies 89.1 89 2109678 (4), 18220710 (3), 9452821 (2), 11137177 (2) (see all 59)
    diabetic cataract 84 15 12871135 (2), 16639016 (2), 1907924 (1), 14751239 (1) (see all 10)
    hyperglycemia 75 47 15539002 (2), 7838591 (2), 19383984 (2), 1314495 (1) (see all 34)
    diabetic retinopathy 74.8 66 12446366 (5), 17548166 (3), 19587357 (3), 16545977 (3) (see all 37)
    retinopathy 72.8 27 8174849 (2), 12446366 (1), 8288059 (1), 15369682 (1) (see all 23)
    diabetic nephropathies 70 39 16620264 (4), 16631535 (2), 12408275 (1), 18325349 (1) (see all 24)
    microangiopathy diabetic 66.1 8 10898124 (2), 16911628 (1), 1841026 (1), 15999695 (1)
    diabetes mellitus 65.5 28 1902410 (1), 7839671 (1), 18451330 (1), 19373836 (1) (see all 25)
    sensorimotor polyneuropathy 65.5 3 15451902 (2), 16373898 (1)
    autonomic neuropathy 65.1 8 10369429 (2), 8482988 (1), 2125013 (1), 18220710 (1) (see all 5)

    Genetic Association Database (GAD): AKR1B1
    Human Genome Epidemiology (HuGE) Navigator: AKR1B1 (36 documents)

    Export disorders for AKR1B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AKR1B1 gene, integrated from 10 sources (see all 870):
    (articles sorted by number of sources associating them with AKR1B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variants in the gene encoding aldose reductase (AKR1B1) and diabetic nephropathy in American Indians. (PubMed id 16620264)1, 4, 9 Wolford J.K....Hanson R.L. (Diabet. Med. 2006)
    2. Aldose reductase is involved in long-term adaptation of EUE cells to hyperosmotic stress. (PubMed id 8435445)1, 2, 9 Ferraretto A....Ronchi S. (Biochim. Biophys. Acta 1993)
    3. Cloning and expression of human aldose reductase. (PubMed id 2112546)1, 2, 9 Nishimura C.... Flynn T.G. (J. Biol. Chem. 1990)
    4. Cloning and prokaryotic expression of a biologically active human placental aldose reductase. (PubMed id 2111143)1, 2, 9 Grundmann U.... Amann E. (DNA Cell Biol. 1990)
    5. Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes. (PubMed id 20353610)1, 4, 9 Prasad P....Thelma B.K. (BMC Med. Genet. 2010)
    6. The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant. (PubMed id 9405046)1, 2, 9 Harrison D.H.... Gabbay K.H. (Biochemistry 1997)
    7. The -106CC genotype of the aldose reductase gene is associated with an increased risk of proliferative diabetic retinopathy in Caucasian-Brazilians with type 2 diabetes. (PubMed id 16545977)1, 4, 9 dos Santos K.G....Roisenberg I. (Mol. Genet. Metab. 2006)
    8. Aldose reductase gene is associated with diabetic macroangiopathy in Japanese Type 2 diabetic patients. (PubMed id 16911628)1, 4, 9 Watarai A....Nakamura J. (Diabet. Med. 2006)
    9. C(-106)T polymorphism of the aldose reductase gene and the progression rate of diabetic retinopathy. (PubMed id 16701918)1, 4, 9 Olmos P....Castro J. (Diabetes Res. Clin. Pract. 2006)
    10. [Association study between diabetic retinopathy and aldose reductase gene polymorphism in Tunisians]. (PubMed id 15973199)1, 4, 9 Zghal-Mokni I....Abdelhak S. (J Fr Ophtalmol 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 231 HGNC: 381 AceView: AKR1B1 Ensembl:ENSG00000085662 euGenes: HUgn231
    ECgene: AKR1B1 Kegg: 231 H-InvDB: AKR1B1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for AKR1B1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AKR1B1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AKR1B1 gene:
    Search GeneIP for patents involving AKR1B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of AKR1B1
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for AKR1B1   OriGene RNAi products in human, mouse, rat for AKR1B1  
     OriGene qPCR primer pairs and template standards for AKR1B1   OriGene Protein Over-expression Lysate for AKR1B1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for AKR1B1  
     OriGene qSTAR qPCR primer pairs in human, mouse for AKR1B1   OriGene Purified Protein for AKR1B1  
     OriGene ORF clones in mouse, rat for AKR1B1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AKR1B1   OriGene Custom Protein Services for AKR1B1  

     
     
     Block miRNA regulation of human, mouse, rat AKR1B1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AKR1B1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKR1B1 Predesigned siRNA for gene silencing in human, mouse, rat AKR1B1
     QuantiFast Probe-based Assays in human, mouse, rat AKR1B1 QuantiTect SYBR Green Assays in human, mouse, rat AKR1B1
     PCR Arrays including human, mouse, rat AKR1B1 Search Chromatin IP Primers for AKR1B1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AKR1B1  GeneGlobe Interaction Network for AKR1B1
     Regulatory tfbs in AKR1B1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for AKR1B1 GenScript cDNA clones with any tag delivered in your preferred vector for AKR1B1
     GenScript Custom Assay Services for AKR1B1 GenScript Custom overexpressing Cell Line Services for AKR1B1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for AKR1B1
     Proteins for AKR1B1
     Browse Sino Biological Cell Lysates
     cDNA Clones for AKR1B1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     AKR1B1 antibodies
     AKR1B1 proteins
     AKR1B1 lysates
     Antibodies for AKR1B1
     See all of Abcam's Antibodies, Kits and Proteins for AKR1B1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for AKR1B1
     Proteins for AKR1B1
     Antibodies for AKR1B1
     ELISAs for AKR1B1
     CLIAs for AKR1B1



     Browse ESI BIO Cell Lines and PureStem Progenitors for AKR1B1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKR1B1
     SwitchGear 3'UTR luciferase reporter plasmids for AKR1B1
     SwitchGear Promoter luciferase reporter plasmids for AKR1B1
     ThermoFisher Antibody for AKR1B1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKR1B1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AKR1B1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AKR1B1
     LSBio Antibodies in human, mouse, rat for AKR1B1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AKR1B1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4