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Aliases for AKR1A1 Gene

Aliases for AKR1A1 Gene

  • Aldo-Keto Reductase Family 1, Member A1 (Aldehyde Reductase) 2 3 5
  • Aldo-Keto Reductase Family 1 Member A1 3 4
  • Dihydrodiol Dehydrogenase 3 2 3
  • Aldehyde Reductase 3 4
  • EC 1.1.1.2 4 63
  • ALDR1 3 4
  • ALR 3 4
  • Epididymis Secretory Sperm Binding Protein Li 165mP 3
  • Epididymis Secretory Protein Li 6 3
  • Alcohol Dehydrogenase 3
  • HEL-S-165mP 3
  • EC 1.1.1 63
  • HEL-S-6 3
  • ARM 3
  • DD3 3

External Ids for AKR1A1 Gene

Previous GeneCards Identifiers for AKR1A1 Gene

  • GC01P045743
  • GC01P045016
  • GC01P045446
  • GC01P045429
  • GC01P045685
  • GC01P045789
  • GC01P046017
  • GC01P044128

Summaries for AKR1A1 Gene

Entrez Gene Summary for AKR1A1 Gene

  • This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]

GeneCards Summary for AKR1A1 Gene

AKR1A1 (Aldo-Keto Reductase Family 1, Member A1 (Aldehyde Reductase)) is a Protein Coding gene. Diseases associated with AKR1A1 include Ethylene Glycol Poisoning and Fetal Alcohol Syndrome. Among its related pathways are Glycosaminoglycan metabolism and Tryptophan metabolism. GO annotations related to this gene include oxidoreductase activity and alditol:NADP+ 1-oxidoreductase activity. An important paralog of this gene is AKR1B1.

UniProtKB/Swiss-Prot for AKR1A1 Gene

  • Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).

Gene Wiki entry for AKR1A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR1A1 Gene

Genomics for AKR1A1 Gene

Regulatory Elements for AKR1A1 Gene

Enhancers for AKR1A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AKR1A1 on UCSC Golden Path with GeneCards custom track

Promoters for AKR1A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AKR1A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AKR1A1 Gene

Chromosome:
1
Start:
45,550,543 bp from pter
End:
45,570,051 bp from pter
Size:
19,509 bases
Orientation:
Plus strand

Genomic View for AKR1A1 Gene

Genes around AKR1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKR1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKR1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR1A1 Gene

Proteins for AKR1A1 Gene

  • Protein details for AKR1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14550-AK1A1_HUMAN
    Recommended name:
    Alcohol dehydrogenase [NADP(+)]
    Protein Accession:
    P14550
    Secondary Accessions:
    • A8KAL8
    • D3DQ04
    • Q6IAZ4

    Protein attributes for AKR1A1 Gene

    Size:
    325 amino acids
    Molecular mass:
    36573 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for AKR1A1 Gene

neXtProt entry for AKR1A1 Gene

Proteomics data for AKR1A1 Gene at MOPED

Post-translational modifications for AKR1A1 Gene

  • Ubiquitination at Lys 153
  • Modification sites at PhosphoSitePlus

Domains & Families for AKR1A1 Gene

Gene Families for AKR1A1 Gene

Protein Domains for AKR1A1 Gene

Suggested Antigen Peptide Sequences for AKR1A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14550

UniProtKB/Swiss-Prot:

AK1A1_HUMAN :
  • Belongs to the aldo/keto reductase family.
Family:
  • Belongs to the aldo/keto reductase family.
genes like me logo Genes that share domains with AKR1A1: view

Function for AKR1A1 Gene

Molecular function for AKR1A1 Gene

GENATLAS Biochemistry:
aldehyde reductase 1,monomeric NADPH dependent,expressed in many organs predominantly in kidney,cortex,liver,thyroid,small intestine,cytosolic reducing various biogenic and xenobiotic aldehyde compounds,with two alternatively spliced transcripts encoding the same protein
UniProtKB/Swiss-Prot CatalyticActivity:
An alcohol + NADP(+) = an aldehyde + NADPH.
UniProtKB/Swiss-Prot Function:
Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).

Enzyme Numbers (IUBMB) for AKR1A1 Gene

genes like me logo Genes that share phenotypes with AKR1A1: view

Animal Models for AKR1A1 Gene

MGI Knock Outs for AKR1A1:

Animal Model Products

miRNA for AKR1A1 Gene

miRTarBase miRNAs that target AKR1A1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AKR1A1 Gene

Localization for AKR1A1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKR1A1 Gene COMPARTMENTS Subcellular localization image for AKR1A1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AKR1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
genes like me logo Genes that share ontologies with AKR1A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for AKR1A1 Gene

Pathways & Interactions for AKR1A1 Gene

genes like me logo Genes that share pathways with AKR1A1: view

Gene Ontology (GO) - Biological Process for AKR1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006081 cellular aldehyde metabolic process TAS 2498333
GO:0019640 glucuronate catabolic process to xylulose 5-phosphate TAS --
GO:0019853 L-ascorbic acid biosynthetic process IEA --
GO:0042840 D-glucuronate catabolic process IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with AKR1A1: view

No data available for SIGNOR curated interactions for AKR1A1 Gene

Drugs & Compounds for AKR1A1 Gene

(55) Drugs for AKR1A1 Gene - From: DrugBank, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Enzyme 1924
Zinc Approved Pharma 2102
Doxorubicin Approved, Investigational Pharma Enzyme, substrate Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1649
Doxil Approved June 1999 Pharma DNA intercalator and TOPO II inhibitor, Topoisomerase 2 Inhibitors 1649
Glycerol Experimental Pharma 205

(90) Additional Compounds for AKR1A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
6-Hydroxyhexanoic acid
  • 6-Hydroxyhexanoate
  • 6-Hydroxyhexanoic acid
1191-25-9
Adipate semialdehyde
  • 6-Oxohexanoate
  • 6-Oxohexanoic acid
  • Hexan-1-one-6-carboxylate
928-81-4
genes like me logo Genes that share compounds with AKR1A1: view

Transcripts for AKR1A1 Gene

Unigene Clusters for AKR1A1 Gene

Aldo-keto reductase family 1, member A1 (aldehyde reductase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKR1A1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^
SP1: - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - -
SP9: - - - -
SP10: - - - -
SP11: - - - - - - - - -
SP12: - - - - -
SP13: - - - - - - -
SP14: - - - - - -
SP15:
SP16: - - -
SP17: - -
SP18:
SP19: - - - - -

ExUns: 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11
SP1: -
SP2: -
SP3: - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - - -
SP19:

Relevant External Links for AKR1A1 Gene

GeneLoc Exon Structure for
AKR1A1
ECgene alternative splicing isoforms for
AKR1A1

Expression for AKR1A1 Gene

mRNA expression in normal human tissues for AKR1A1 Gene

Protein differential expression in normal tissues from HIPED for AKR1A1 Gene

This gene is overexpressed in Liver, secretome (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKR1A1 Gene



SOURCE GeneReport for Unigene cluster for AKR1A1 Gene Hs.474584

mRNA Expression by UniProt/SwissProt for AKR1A1 Gene

P14550-AK1A1_HUMAN
Tissue specificity: Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
genes like me logo Genes that share expression patterns with AKR1A1: view

Protein tissue co-expression partners for AKR1A1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AKR1A1 Gene

Orthologs for AKR1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AKR1A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AKR1A1 35
  • 90.56 (n)
  • 93.23 (a)
AKR1A1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKR1A1 35
  • 90.05 (n)
  • 94.77 (a)
AKR1A1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akr1a1 35
  • 87.79 (n)
  • 93.23 (a)
Akr1a1 16
Akr1a1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AKR1A1 35
  • 99.59 (n)
  • 99.69 (a)
AKR1A1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akr1a1 35
  • 87.59 (n)
  • 94.15 (a)
oppossum
(Monodelphis domestica)
Mammalia AKR1A1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKR1A1 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves AKR1A1 35
  • 71.79 (n)
  • 78.46 (a)
AKR1A1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKR1A1 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia akr1a1 35
  • 69.18 (n)
  • 74.53 (a)
Str.11963 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.10170 35
zebrafish
(Danio rerio)
Actinopterygii akr1a1b 35
  • 65.62 (n)
  • 72.1 (a)
Dr.13132 35
akr1a1b 36
  • 70 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1439 35
fruit fly
(Drosophila melanogaster)
Insecta CG10638 37
  • 40 (a)
CG12766 37
  • 40 (a)
CG2767 37
  • 42 (a)
CG6083 37
  • 47 (a)
CG6084 37
  • 49 (a)
CG9436 37
  • 41 (a)
ARY 36
  • 31 (a)
OneToMany
CG10638 36
  • 41 (a)
OneToMany
CG10863 36
  • 40 (a)
OneToMany
CG12766 36
  • 39 (a)
OneToMany
CG6083 36
  • 45 (a)
OneToMany
CG9436 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C01G5.5 37
  • 31 (a)
C07D8.6 37
  • 38 (a)
C35D10.6 37
  • 31 (a)
F53F1.2 37
  • 34 (a)
F53F1.3 37
  • 35 (a)
K07C5.2 37
  • 31 (a)
T08H10.1 37
  • 41 (a)
Y39G8B.1a 37
  • 45 (a)
Y39G8B.1b 37
  • 45 (a)
Y39G8B.2 37
  • 34 (a)
ZC443.1 37
  • 37 (a)
C07D8.5 36
  • 28 (a)
OneToMany
C07D8.6 36
  • 39 (a)
OneToMany
T08H10.1 36
  • 41 (a)
OneToMany
Y39G8B.1 36
  • 46 (a)
OneToMany
Y39G8B.2 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRE3 36
  • 37 (a)
OneToMany
GCY1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G37760 35
  • 51.14 (n)
  • 48.11 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3560 35
barley
(Hordeum vulgare)
Liliopsida Hv.12012 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04510 35
  • 48.86 (n)
  • 41.67 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC26F1.07 35
  • 49.94 (n)
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
ManyToMany
CSA.5991 36
  • 15 (a)
ManyToMany
Species with no ortholog for AKR1A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AKR1A1 Gene

ENSEMBL:
Gene Tree for AKR1A1 (if available)
TreeFam:
Gene Tree for AKR1A1 (if available)

Paralogs for AKR1A1 Gene

(11) SIMAP similar genes for AKR1A1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for AKR1A1 Gene

genes like me logo Genes that share paralogs with AKR1A1: view

Variants for AKR1A1 Gene

Sequence variations from dbSNP and Humsavar for AKR1A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2229540 - 45,566,639(+) CGGCA(A/G)TGAGC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs6690497 - 45,566,649(+) CCTGA(C/G)ATTGG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs9147 -- 45,551,015(+) TCCTT(C/T)ATGCC nc-transcript-variant, utr-variant-5-prime
rs486346 -- 45,561,189(+) CTTCT(C/G)TGTGG intron-variant
rs532639 -- 45,558,809(+) acagg(C/T)gtgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKR1A1 Gene

Variant ID Type Subtype PubMed ID
nsv829726 CNV Loss 17160897
nsv871928 CNV Gain 21882294

Variation tolerance for AKR1A1 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.70% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AKR1A1 Gene

Disorders for AKR1A1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for AKR1A1 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
ethylene glycol poisoning
fetal alcohol syndrome
  • alcohol-related neurodevelopmental disorder
methanol poisoning
duodenal ulcer
  • curling ulcer
alcohol abuse
  • alcoholism
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for AKR1A1

Genetic Association Database (GAD)
AKR1A1
Human Genome Epidemiology (HuGE) Navigator
AKR1A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKR1A1
genes like me logo Genes that share disorders with AKR1A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AKR1A1 Gene

Publications for AKR1A1 Gene

  1. The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p33-->p32. (PMID: 10393438) Fujii J. … Taniguchi N. (Cytogenet. Cell Genet. 1999) 2 3 4 23 67
  2. Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma. (PMID: 17149600) Lan Q. … Chanock S. (Hum. Genet. 2007) 3 23
  3. Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. (PMID: 16792560) Lee S.L. … Yin S.J. (Alcohol. Clin. Exp. Res. 2006) 25 26
  4. Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. (PMID: 10510318) O'Connor T. … Hayes J.D. (Biochem. J. 1999) 3 23
  5. The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases. (PMID: 2498333) Bohren K.M. … Gabbay K.H. (J. Biol. Chem. 1989) 2 3

Products for AKR1A1 Gene

Sources for AKR1A1 Gene

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