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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AKR1A1 Gene

protein-coding   GIFtS: 69
GCID: GC01P046017

Aldo-Keto Reductase Family 1, Member A1 (Aldehyde Reductase)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Aldo-Keto Reductase Family 1, Member A1 (Aldehyde Reductase)1 2     EC 1.1.1.23 8
ALR2 3 5     ARM2
Dihydrodiol Dehydrogenase 31 2     DD32
Aldehyde Reductase2 3     Alcohol Dehydrogenase2
Aldo-Keto Reductase Family 1 Member A12 3     Alcohol Dehydrogenase [NADP(+)]2
ALDR12 3     EC 1.1.18

External Ids:    HGNC: 3801   Entrez Gene: 103272   Ensembl: ENSG000001174487   OMIM: 1038305   UniProtKB: P145503   

Export aliases for AKR1A1 gene to outside databases

Previous GC identifers: GC01P045743 GC01P045016 GC01P045446 GC01P045429 GC01P045685 GC01P045789 GC01P044128


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AKR1A1 Gene:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes
and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and
xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants
of this gene exist, all encoding the same protein. (provided by RefSeq, Jan 2011)

GeneCards Summary for AKR1A1 Gene: 
AKR1A1 (aldo-keto reductase family 1, member A1 (aldehyde reductase)) is a protein-coding gene. Diseases associated with AKR1A1 include ethylene glycol poisoning, and methanol poisoning, and among its related super-pathways are Benzo(a)pyrene metabolism and Cyclophosphamide Pathway, Pharmacodynamics. GO annotations related to this gene include electron carrier activity and L-glucuronate reductase activity. An important paralog of this gene is AKR1C2.

UniProtKB/Swiss-Prot: AK1A1_HUMAN, P14550
Function: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their
corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol.
Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde,
1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such
as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs,
including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN)

Gene Wiki entry for AKR1A1 (Aldo-keto reductase family 1, member A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AKR1A1 gene promoter:
         Max   C/EBPbeta   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAKR1A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AKR1A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKR1A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33-p32   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p33-p32

AKR1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKR1A1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P046017:  view genomic region     (about GC identifiers)

Start:
46,016,215 bp from pter      End:
46,035,723 bp from pter
Size:
19,509 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AK1A1_HUMAN, P14550 (See protein sequence)
Recommended Name: Alcohol dehydrogenase [NADP(+)]  
Size: 325 amino acids; 36573 Da
Subunit: Monomer (By similarity)
1 PDB 3D structure from and Proteopedia for AKR1A1:
2ALR (3D)    
Secondary accessions: A8KAL8 D3DQ04 Q6IAZ4

Explore the universe of human proteins at neXtProt for AKR1A1: NX_P14550

Explore proteomics data for AKR1A1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14550

  • 4/10 DME Specific Peptides for AKR1A1 (P14550) (see all 10)
     AAIYGNE  GLGTWKS  GYRHIDCA  MPLIGLGT 

    AKR1A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AKR1A1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001189343.1  NP_006057.1  NP_697021.1  NP_001189342.1  

    ENSEMBL proteins: 
     ENSP00000361140   ENSP00000398414   ENSP00000312606  

    Human Recombinant Protein Products for AKR1A1: 
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    ProSpec Recombinant Protein for AKR1A1
    Cloud-Clone Corp. Proteins for AKR1A1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0016324apical plasma membrane IEA--

    AKR1A1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AKR: Aldo-keto reductases

    4 InterPro protein domains:
     IPR001395 Aldo/ket_red
     IPR018170 Aldo/ket_reductase_CS
     IPR020471 Aldo/keto_reductase_subgr
     IPR023210 NADP_OxRdtase_dom

    Graphical View of Domain Structure for InterPro Entry P14550

    ProtoNet protein and cluster: P14550

    1 Blocks protein domain: IPB001395 Aldo/keto reductase

    UniProtKB/Swiss-Prot: AK1A1_HUMAN, P14550
    Similarity: Belongs to the aldo/keto reductase family


    AKR1A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AK1A1_HUMAN, P14550
    Function: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their
    corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol.
    Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde,
    1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such
    as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs,
    including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN)
    Catalytic activity: An alcohol + NADP(+) = an aldehyde + NADPH

         Genatlas biochemistry entry for AKR1A1:
    aldehyde reductase 1,monomeric NADPH dependent,expressed in many organs predominantly in
    kidney,cortex,liver,thyroid,small intestine,cytosolic reducing various biogenic and xenobiotic aldehyde
    compounds,with two alternatively spliced transcripts encoding the same protein

         Enzyme Numbers (IUBMB): EC 1.1.1.21 2 EC 1.1.12

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004032alditol:NADP+ 1-oxidoreductase activity IEA--
    GO:0009055electron carrier activity TAS2498333
    GO:0047939L-glucuronate reductase activity IEA--
         
    AKR1A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AKR1A1:
     Synthetic lethal with Ras 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Akr1a1):
     cellular  craniofacial  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system  reproductive system  respiratory system  skeleton 

    AKR1A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Akr1a1tm1Maka for AKR1A1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AKR1A1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AKR1A1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AKR1A1 About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Naphthalene metabolism
    Naphthalene metabolism0.32
    Benzo(a)pyrene metabolism0.32
    2Ifosfamide Pathway, Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics0.72
    Cyclophosphamide Pathway, Pharmacodynamics0.72
    3tryptophan utilization II
    tryptophan utilization I0.70
    4Glycolysis and gluconeogenesis (short map)
    Glycolysis / Gluconeogenesis0.46
    5Doxorubicin Pathway, Pharmacokinetics
    Doxorubicin Pathway, Pharmacokinetics0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for AKR1A1
        Prostaglandin 2 biosynthesis and metabolism FM
    Naphthalene metabolism


    2 GeneGo (Thomson Reuters) Pathways for AKR1A1
        Naphthalene metabolism
    Prostaglandin 2 biosynthesis and metabolism FM

    4 BioSystems Pathways for AKR1A1
        Benzo(a)pyrene metabolism
    tryptophan degradation X (mammalian, via tryptamine)
    metapathway biotransformation
    tryptophan utilization I


    4 PharmGKB Pathways for AKR1A1
        Cyclophosphamide Pathway, Pharmacodynamics
    Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics
    Ifosfamide Pathway, Pharmacodynamics

    4         Kegg Pathways  (Kegg details for AKR1A1):
        Glycolysis / Gluconeogenesis
    Glycerolipid metabolism
    Metabolic pathways
    Degradation of aromatic compounds


    AKR1A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AKR1A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/65 Interacting proteins for AKR1A1 (P145503 ENSP000003126064) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC4Q9NPD33, ENSP000003154764I2D: score=4 STRING: ENSP00000315476
    ISYNA1Q9NPH23I2D: score=4 
    PRPF6O949063I2D: score=3 
    AARSP495883I2D: score=1 
    ACAT1P247523I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006006glucose metabolic process TAS2498333
    GO:0006081cellular aldehyde metabolic process TAS2498333
    GO:0019853L-ascorbic acid biosynthetic process IEA--
    GO:0042840D-glucuronate catabolic process IEA--
    GO:0046185aldehyde catabolic process IEA--

    AKR1A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AKR1A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for AKR1A1 (AK1A1)

    10/17 HMDB Compounds for AKR1A1 (see all 17)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    6-Hydroxyhexanoic acid6-Hydroxyhexanoate (see all 2)1191-25-9--
    Acetaldehydeacetaldehyde (see all 5)75-07-0--
    Adipate semialdehydeHexan-1-one-6-carboxylate (see all 3)928-81-4--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Glyceraldehyde(+/-)-2,3-dihydroxy-Propanal (see all 24)56-82-6--
    Glycerol1,2,3-Trihydroxypropane (see all 22)56-81-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--

    5 DrugBank Compounds for AKR1A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target--10592235
    DoxorubicinAdria (see all 4)23214-92-8enzymesubstrate18635746
    NADHbeta-DPNH (see all 18)606-68-8enzymesubstrate19583966
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--10592235
    Tolrestat-- 82964-04-3target--10592235

    10/129 Novoseek inferred chemical compound relationships for AKR1A1 gene (see all 129)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4-methylpyrazole 93.9 79 8865952 (2), 11762672 (2), 2282461 (1), 2099148 (1) (see all 52)
    acetaldehyde 91.9 128 8892513 (4), 17590984 (2), 9795248 (2), 8541036 (2) (see all 99)
    m-nitrobenzaldehyde 91.1 1 11329488 (1)
    ethanol 87.6 347 14718645 (5), 8244116 (4), 11586401 (3), 2041490 (2) (see all 99)
    nad+ 82.1 53 2099148 (1), 9529900 (1), 12827287 (1), 15720144 (1) (see all 47)
    p-nitrosodimethylaniline 81.4 1 9581470 (1)
    nadh 78.1 52 9432004 (2), 9516661 (1), 15808017 (1), 17015264 (1) (see all 43)
    n-benzylformamide 74.3 2 15449945 (1)
    ethylene glycol 71.2 32 11434452 (3), 8865952 (2), 11099610 (2), 9806434 (2) (see all 22)
    pyrazole 70.3 9 1993997 (1), 1590543 (1), 7847607 (1), 7646056 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about AKR1A1 / AK1A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for AKR1A1 gene (4 alternative transcripts): 
    NM_001202414.1  NM_006066.3  NM_153326.2  NM_001202413.1  

    Unigene Cluster for AKR1A1:

    Aldo-keto reductase family 1, member A1 (aldehyde reductase)
    Hs.474584  [show with all ESTs]
    Unigene Representative Sequence: NM_006066
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372070(uc021omx.1 uc021omy.1 uc001cod.3 uc001coe.3)
    ENST00000434299 ENST00000496999 ENST00000476957 ENST00000481885 ENST00000351829
    ENST00000471651(uc009vxw.3) ENST00000497973 ENST00000473038(uc001cof.3)
    ENST00000495913 ENST00000487654 ENST00000475919 ENST00000475985
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK293083.1 AK307068.1 AK307237.1 AK307288.1 AK311175.1 BC000670.2 BC005394.1 BC033287.1 
    BT007003.1 CR457010.1 J04794.1 

    24/31 DOTS entries (see all 31):

    DT.452914  DT.97860403  DT.100876856  DT.100876857  DT.100876880  DT.100876862  DT.100876859  DT.100876873 
    DT.95265907  DT.100876884  DT.102832770  DT.219220  DT.121387658  DT.92457246  DT.100876869  DT.121387644 
    DT.65287039  DT.95265894  DT.97860404  DT.100876864  DT.100876867  DT.102832769  DT.121387645  DT.121387650 

    24/653 AceView cDNA sequences (see all 653):

    CR616472 AI361095 CD671277 CB242230 BI756060 BM468782 CA448035 BE274146 
    BE407246 D55857 CR593332 BI870205 CD723863 BQ893427 BQ181727 CR617059 
    BE277140 NM_153326 AW071946 BM665881 CA308814 J04794 BE408148 R94643 

    GeneLoc Exon Structure

    5/19 Alternative Splicing Database (ASD) splice patterns (SP) for AKR1A1 (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^
    SP1:                                                                                                                                -     -     -               
    SP2:                                                                    -     -     -                                               -     -     -               
    SP3:                                                                                                                                -     -     -               
    SP4:                                                                                                                                -     -     -               
    SP5:                                      -                                                                                                                     

    ExUns: 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11
    SP1:                          -               
    SP2:                          -               
    SP3:  -     -     -           -               
    SP4:  -     -     -           -               
    SP5:                                          


    ECgene alternative splicing isoforms for AKR1A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AKR1A1 expression in normal human tissues (normalized intensities)      AKR1A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGTGATCCT
    AKR1A1 Expression
    About this image


    AKR1A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Thalamus
             brain/midbrain   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Membranous Facial Bones
             sensory organ/ear/inner ear   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See AKR1A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AKR1A1

    SOURCE GeneReport for Unigene cluster: Hs.474584

    UniProtKB/Swiss-Prot: AK1A1_HUMAN, P14550
    Tissue specificity: Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea,
    stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AKR1A1 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akr1a11 , 5 aldo-keto reductase family 1, member A1 (aldehyde reductase)1, 5 87.79(n)1
    93.23(a)1
      4 (53.26 cM)5
    588101  NM_021473.31  NP_067448.11 
     1166365105 
    chicken
    (Gallus gallus)
    Aves AKR1A11 aldo-keto reductase family 1, member A1 (aldehyde reductase) 71.79(n)
    78.46(a)
      424599  NM_001006539.1  NP_001006539.1 
    lizard
    (Anolis carolinensis)
    Reptilia AKR1A16
    --
    Uncharacterized protein
    68(a)
    40(a)
    1 ↔ 1
    possible ortholog
    AAWZ02036488(4841-25880)
    AAWZ02039178(2232-9123)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.101702 Xenopus laevis transcribed sequence with moderate similarity more 74.45(n)    CF520439.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.131322 Transcribed sequence with weak similarity to protein more 74.99(n)    CK237455.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60843 aldehyde reductase 49(a)
    (best of 6)
      68C15   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y39G8B.1a3   -- 45(a)
    (best of 11)
      II(13970799-13972831)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GCY1(YOR120W)4 Putative NADP(+) coupled glycerol dehydrogenase, proposed more   --   15(551114-552052) 854287  NP_014763.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G377601 NAD(P)-linked oxidoreductase-like protein 51.14(n)
    48.11(a)
      818353  NM_201897.3  NP_973626.2 
    rice
    (Oryza sativa)
    Liliopsida NM_194590.12   -- 70.33(n)    NM_194590.1 


    ENSEMBL Gene Tree for AKR1A1 (if available)
    TreeFam Gene Tree for AKR1A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AKR1A1 gene
    AKR1C22  AKR1CL12  AKR1C32  AKR1B102  AKR1C42  AKR1E22  AKR1B152  AKR1B12  
    AKR1D12  AKR1C12  
    11 SIMAP similar genes for AKR1A1 using alignment to 2 protein entries:     AK1A1_HUMAN (see all proteins):
    AKR1B1    AKR1B10    AKR1B15    AKR1C1    AKR1C2    AKR1D1
    AKR1C4    AKR1CL1    AKR1E2    AKR1C3    LOC402299

    AKR1A1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for AKR1A1
    PGOHUM00000242595


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/547 SNPs in AKR1A1 are shown (see all 547)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1997792971,2
    --46014533(+) TTTTA-/TTTTTT 4 -- us2k10--------
    rs24534041,2
    C,F--46014735(+) aggctG/Agagtg 4 -- us2k18Minor allele frequency- A:0.44NA WA CSA EA 368
    rs1830737761,2
    C--46014897(+) TTGTTA/GCCCAG 4 -- us2k10--------
    rs1877114291,2
    --46014953(+) CCCAGA/GTTCAA 4 -- us2k10--------
    rs120776211,2
    C,F--46015005(+) GGCATA/GTGCCA 4 -- us2k15Minor allele frequency- G:0.44NA CSA 9
    rs1925187011,2
    --46015136(+) ACAGGC/TGTGAG 4 -- us2k10--------
    rs1476608601,2
    C--46015152(+) GCACCC/TGGCCA 4 -- us2k10--------
    rs112111381,2
    C,F,A--46015157(+) CGGCCG/AAGTCT 4 -- us2k111Minor allele frequency- A:0.16NA WA CSA EA 373
    rs6227981,2
    C,F,A,H--46015271(+) AGAGTG/TGCTCT 4 -- us2k123Minor allele frequency- T:0.46MN NS EA NA WA CSA 2534
    rs1397016311,2
    --46015526(+) ATGGTA/GTGCTG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for AKR1A1 (46016215 - 46035723 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AKR1A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829726CNV Loss17160897
    nsv871928CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 103830    OMIM disorders: --

    20/75 diseases for AKR1A1 (see all 75):    About MalaCards
    ethylene glycol poisoning    methanol poisoning    hangover    pancreatic cystadenoma
    alcoholic cardiomyopathy    alcohol-related birth defect    fetal alcohol syndrome    alcohol dependence
    anoxia    alcoholic liver cirrhosis    metabolic acidosis    alcohol abuse
    birth defects    cluster headache    jaundice    peptic ulcer
    alcoholism    liver cirrhosis    viral hepatitis    alcoholic hepatitis


    AKR1A1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/52 Novoseek inferred disease relationships for AKR1A1 gene (see all 52)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alcoholism 75 49 9463245 (4), 10733556 (2), 9066994 (2), 8244116 (1) (see all 39)
    liver diseases alcoholic 67.9 6 15698522 (2), 2379876 (1), 9373704 (1), 9731720 (1) (see all 5)
    metabolic acidosis 59.4 6 18375643 (1), 18958433 (1), 12448112 (1)
    fetal alcohol syndrome 58.4 3 7748347 (2), 1877746 (1)
    alcohol abuse 55.7 2 2408260 (1), 11704927 (1)
    alcoholic cirrhosis 53.3 6 20171022 (2), 19404864 (1), 1592339 (1), 8325617 (1) (see all 5)
    poisoning 52.9 20 11172179 (2), 16035197 (2), 11099610 (2), 10497633 (1) (see all 16)
    intoxication 50.6 12 9865242 (1), 11392120 (1), 11979651 (1), 8865952 (1) (see all 11)
    pancreatitis alcoholic 35.8 1 8986224 (1)
    cirrhosis 30.9 3 1592339 (1), 8428716 (1)

    Genetic Association Database (GAD): AKR1A1
    Human Genome Epidemiology (HuGE) Navigator: AKR1A1 (9 documents)

    Export disorders for AKR1A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AKR1A1 gene, integrated from 9 sources (see all 791):
    (articles sorted by number of sources associating them with AKR1A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p33-->p32. (PubMed id 10393438)1, 2, 3, 9 Fujii J.... Taniguchi N. (1999)
    2. The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases. (PubMed id 2498333)1, 2, 3 Bohren K.M.... Gabbay K.H. (1989)
    3. Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. (PubMed id 10510318)1, 2, 9 O'Connor T.... Hayes J.D. (1999)
    4. Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma. (PubMed id 17149600)1, 4, 9 Lan Q....Chanock S. (2007)
    5. Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma. (PubMed id 16543247)1, 4, 9 Wang S.S....Rothman N. (2006)
    6. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    7. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    8. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
    9. Genetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non-Hodgkin lymphoma. (PubMed id 19423521)1, 4 Han X....Zhang Y. (2009)
    10. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10327 HGNC: 380 AceView: AKR1A1 Ensembl:ENSG00000117448 euGenes: HUgn10327
    ECgene: AKR1A1 Kegg: 10327 H-InvDB: AKR1A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AKR1A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AKR1A1 gene:
    Search GeneIP for patents involving AKR1A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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