AKNAD1 Gene
protein-coding GIFtS: 39
GCID: GC01M109359
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AKNA domain containing 1(Previous name: chromosome 1 open reading frame 62 )
(Previous symbol: C1orf62)
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Aliases
for AKNAD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| AKNA Domain Containing 11 2 | | C1orf621 2 3 | | MGC269891 | | Chromosome 1 Open Reading Frame 621 | | Protein AKNAD12 |
Export aliases for AKNAD1 gene to outside databasesPrevious GC identifers: GC01M109161 GC01M107251 |
Summaries
for AKNAD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for AKNAD1:
This gene encodes a protein which contains a domain found in an AT-hook-containing transcription factor. Alternativesplicing results in multiple transcript variants. (provided by RefSeq, May 2012)
|
Genomic Views
for AKNAD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for AKNAD1
Other transcription factors
Search SABiosciences Chromatin IP Primers for AKNAD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKNAD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3AKNAD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M109359: view genomic region
(about GC identifiers)
Start:
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109,358,520 bp from pter |
End:
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109,506,106 bp from pter |
Size:
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147,587 bases |
Orientation:
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minus strand |
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Proteins
for AKNAD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AKND1_HUMAN, Q5T1N1 (See
protein sequence)Recommended Name: Protein AKNAD1 Size: 836 amino acids; 92864 Da
Secondary accessions: B9EK62 Q5T1N0 Q8N990 Q8NCN9Alternative splicing: 4 isoforms: Q5T1N1-1 Q5T1N1-2 Q5T1N1-3 Q5T1N1-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for AKNAD1: NX_Q5T1N1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T1N1
AKNAD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689976.2
ENSEMBL proteins: ENSP00000359018 ENSP00000436835 ENSP00000359011 ENSP00000359012 ENSP00000433889 ENSP00000432262 ENSP00000349968
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IDA | -- |
AKNAD1 for ontologies About GeneDecksing
AKNAD1 Antibody Products:
Assay Products for AKNAD1: |
Protein
Domains /
Families
for AKNAD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AKNAD1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5T1N1ProtoNet protein and cluster: Q5T1N1 UniProtKB/Swiss-Prot: AKND1_HUMAN, Q5T1N1Similarity: Belongs to the AKNA family |
Function
for AKNAD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKNAD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKNAD1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: AKNAD1 (NM_152763) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AKNAD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKNAD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKNAD1 |
|
Pathways & Interactions
for AKNAD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AKNAD1
|
Drugs & Compounds
for AKNAD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AKNAD1
Search CenterWatch for drugs/clinical trials and news about AKNAD1 / AKND1
|
Transcripts
for AKNAD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AKNAD1 gene: NM_152763.4 Unigene Cluster for AKNAD1: AKNA domain containing 1 Hs.729441 [show with all ESTs]Unigene Representative Sequence: AL8322169 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000466413 ENST00000370001(uc001dwa.3) ENST00000474186(uc001dwb.3)
ENST00000477908 ENST00000369994 ENST00000369995 ENST00000461774 ENST00000472781
ENST00000357393(uc010ovb.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKNAD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKNAD1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AKNAD1 (NM_152763) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AKNAD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKNAD1 |
Additional cDNA sequence: AK095517.1 AK313772.1 AL832216.1 BC030647.2 BC150642.1 NR_049760.1 7 DOTS entries: DT.91827827 DT.412167 DT.99999462 DT.99936986 DT.40214060 DT.86850931 DT.75160811 17 AceView cDNA sequences: BX117233 AK095517 AW263562 AI199179 NM_152763 BX119529 BC030647 BG211366 AL832216 AW183257 BI459450 BX099864 AI651223 AA527539 BG211908 AI825653 BG722609
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for AKNAD1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | - | | | | | | | | | | | | - | | - | | | | | | |
| SP2: | | | - | | - | | - | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | - | | | | | | | | | | | | - | | - | | - | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | |
| ExUns: | 17b | ^ | 18 |
|---|
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| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for AKNAD1
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Expression
for AKNAD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AKNAD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See AKNAD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AKNAD1
SOURCE GeneReport for Unigene cluster: Hs.729441
SABiosciences Custom PCR Arrays for AKNAD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKNAD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AKNAD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKNAD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKNAD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKNAD1 |
Orthologs
for AKNAD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for AKNAD1 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for AKNAD1 (if available)
TreeFam Gene Tree for AKNAD1 (if available) |
Paralogs
for AKNAD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for AKNAD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AKNAD1 (109358520 - 109506106 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for AKNAD1
7 CNVs: 48076 37398 64556 48075 60868 34675 9889 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKNAD1 |
|
Disorders
/ Diseases
for AKNAD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 AKNAD1 for disorders About MalaCards
AKNAD1 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: AKNAD1 (1 document)
Export disorders for AKNAD1 gene to outside databases
|
Publications
for AKNAD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AKNAD1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with AKNAD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for AKNAD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing AKNAD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AKNAD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AKNAD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AKNAD1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for AKNAD1 gene:
Search GeneIP for patents involving AKNAD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AKNAD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for AKNAD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKNAD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKNAD1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AKNAD1 | | OriGene 3'-UTR Clone for AKNAD1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKNAD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKNAD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AKNAD1 | | OriGene Custom Protein Services for AKNAD1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AKNAD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKNAD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKNAD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKNAD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKNAD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKNAD1 |
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 | | | AKNAD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKNAD1 |
|  |  |  | | | | Search ThermoFisher Antibodies for AKNAD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKNAD1 |
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