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Aliases for AKNAD1 Gene

Aliases for AKNAD1 Gene

  • AKNA Domain Containing 1 2 3 5
  • C1orf62 3 4
  • Chromosome 1 Open Reading Frame 62 2

External Ids for AKNAD1 Gene

Previous HGNC Symbols for AKNAD1 Gene

  • C1orf62

Previous GeneCards Identifiers for AKNAD1 Gene

  • GC01M109161
  • GC01M109359
  • GC01M107251

Summaries for AKNAD1 Gene

Entrez Gene Summary for AKNAD1 Gene

  • This gene encodes a protein which contains a domain found in an AT-hook-containing transcription factor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

GeneCards Summary for AKNAD1 Gene

AKNAD1 (AKNA Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is ENSG00000274068.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKNAD1 Gene

Genomics for AKNAD1 Gene

Genomic Location for AKNAD1 Gene

Chromosome:
1
Start:
108,815,898 bp from pter
End:
108,858,242 bp from pter
Size:
42,345 bases
Orientation:
Minus strand

Genomic View for AKNAD1 Gene

Genes around AKNAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKNAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKNAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKNAD1 Gene

No data available for Regulatory Elements for AKNAD1 Gene

Proteins for AKNAD1 Gene

  • Protein details for AKNAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T1N1-AKND1_HUMAN
    Recommended name:
    Protein AKNAD1
    Protein Accession:
    Q5T1N1
    Secondary Accessions:
    • B9EK62
    • Q5T1N0
    • Q8N990
    • Q8NCN9

    Protein attributes for AKNAD1 Gene

    Size:
    836 amino acids
    Molecular mass:
    92864 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AKNAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKNAD1 Gene

Proteomics data for AKNAD1 Gene at MOPED

Post-translational modifications for AKNAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKNAD1 Gene

No data available for DME Specific Peptides for AKNAD1 Gene

Domains & Families for AKNAD1 Gene

Protein Domains for AKNAD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AKNAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T1N1

UniProtKB/Swiss-Prot:

AKND1_HUMAN :
  • Belongs to the AKNA family.
Family:
  • Belongs to the AKNA family.
genes like me logo Genes that share domains with AKNAD1: view

No data available for Gene Families for AKNAD1 Gene

Function for AKNAD1 Gene

Phenotypes for AKNAD1 Gene

genes like me logo Genes that share phenotypes with AKNAD1: view

Animal Model Products

CRISPR Products

miRNA for AKNAD1 Gene

miRTarBase miRNAs that target AKNAD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKNAD1 Gene

Localization for AKNAD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKNAD1 Gene COMPARTMENTS Subcellular localization image for AKNAD1 gene
Compartment Confidence
nucleus 4
cytosol 3
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AKNAD1 Gene

Pathways & Interactions for AKNAD1 Gene

SuperPathways for AKNAD1 Gene

No Data Available

Interacting Proteins for AKNAD1 Gene

Gene Ontology (GO) - Biological Process for AKNAD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AKNAD1 Gene

Drugs & Compounds for AKNAD1 Gene

No Compound Related Data Available

Transcripts for AKNAD1 Gene

mRNA/cDNA for AKNAD1 Gene

Unigene Clusters for AKNAD1 Gene

AKNA domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKNAD1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a ·
SP1: - - - - -
SP2: - - - - - - - - - - - -
SP3:
SP4:
SP5: -
SP6:

ExUns: 17b ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for AKNAD1 Gene

GeneLoc Exon Structure for
AKNAD1
ECgene alternative splicing isoforms for
AKNAD1

Expression for AKNAD1 Gene

mRNA expression in normal human tissues for AKNAD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AKNAD1 Gene

This gene is overexpressed in Testis (x28.4).

Protein differential expression in normal tissues from HIPED for AKNAD1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (54.9) and Platelet (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AKNAD1 Gene



SOURCE GeneReport for Unigene cluster for AKNAD1 Gene Hs.729441

genes like me logo Genes that share expression patterns with AKNAD1: view

Protein tissue co-expression partners for AKNAD1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AKNAD1 Gene

Orthologs for AKNAD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKNAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKNAD1 35
  • 98.92 (n)
  • 97.85 (a)
-- 36
  • 98 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
cow
(Bos Taurus)
Mammalia AKNAD1 36
  • 59 (a)
OneToOne
AKNAD1 35
  • 79.35 (n)
  • 63.28 (a)
dog
(Canis familiaris)
Mammalia AKNAD1 35
  • 79.84 (n)
  • 67.73 (a)
AKNAD1 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aknad1 16
Aknad1 36
  • 54 (a)
OneToOne
Aknad1 35
  • 70.59 (n)
  • 54.93 (a)
oppossum
(Monodelphis domestica)
Mammalia AKNAD1 36
  • 29 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKNAD1 36
  • 36 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aknad1 35
  • 72 (n)
  • 54.79 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii AKNAD1 36
  • 23 (a)
OneToOne
Species with no ortholog for AKNAD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKNAD1 Gene

ENSEMBL:
Gene Tree for AKNAD1 (if available)
TreeFam:
Gene Tree for AKNAD1 (if available)

Paralogs for AKNAD1 Gene

Paralogs for AKNAD1 Gene

genes like me logo Genes that share paralogs with AKNAD1: view

Variants for AKNAD1 Gene

Sequence variations from dbSNP and Humsavar for AKNAD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1277207 - 108,852,483(+) TCTCA(C/T)TATGC nc-transcript-variant, reference, missense
rs17621411 - 108,852,354(+) TAGAA(A/G)CGTCT nc-transcript-variant, reference, missense
rs17852793 - 108,852,165(+) TGAGT(C/T)CTGGG nc-transcript-variant, reference, missense
rs9440631 - 108,851,902(+) GTAAT(A/G)AACTT nc-transcript-variant, reference, missense
rs11580913 - 108,849,040(+) AGAGA(C/G/T)ACTTG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for AKNAD1 Gene

Variant ID Type Subtype PubMed ID
nsv2287 CNV Loss 18451855
nsv463106 CNV Loss 19166990
nsv526819 CNV Loss 19592680
nsv521427 CNV Loss 19592680
dgv63n67 CNV Loss 20364138
esv7631 CNV Loss 19470904
esv2715929 CNV Deletion 23290073
esv2670634 CNV Deletion 23128226
esv26096 CNV Loss 19812545
esv2421353 CNV Deletion 20811451
nsv463117 CNV Loss 19166990
nsv818322 CNV Loss 17921354
nsv517381 CNV Loss 19592680
nsv823943 CNV Loss 20364138

Variation tolerance for AKNAD1 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.91; 74.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKNAD1 Gene

HapMap Linkage Disequilibrium report
AKNAD1
Human Gene Mutation Database (HGMD)
AKNAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKNAD1 Gene

Disorders for AKNAD1 Gene

Relevant External Links for AKNAD1

Genetic Association Database (GAD)
AKNAD1
Human Genome Epidemiology (HuGE) Navigator
AKNAD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKNAD1

No disorders were found for AKNAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKNAD1 Gene

Publications for AKNAD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men. (PMID: 21897333) Irvin M.R. … Arnett D.K. (Pharmacogenet. Genomics 2011) 3

Products for AKNAD1 Gene

Sources for AKNAD1 Gene

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