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Aliases & Descriptions for AKNA
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ31001 2 | | FLJ33184 2 | | KIAA1968 1, 2, 3 | | OTTHUMP00000021973 2 | | RP11-82I1.4 2 |
| | | Descriptions |
|---|
| AKNA transcript F2 2 | | AT-hook transcription factor 2 | | AT-hook transcription factor AKNA 2 |
|
| | Search outside databases for aliases for AKNA genePrevious GC identifers: GC09M107896 GC09M108827 GC09M110552 GC09M112474 GC09M114177 |
Summaries for AKNA(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: AKNA_HUMAN, Q7Z591Function: Transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters |
Genomic Location for AKNA
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the AKNA gene 
Entrez Gene cytogenetic band: 9q32 Ensembl cytogenetic band: 9q32 HGNC cytogenetic band: 9q32AKNA Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M116138:
(about GC identifiers)
Start:
|
116,136,250 bp from pter |
End:
|
116,196,506 bp from pter |
Size:
|
60,257 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000009.10 NT_008470.18
| Proteins for AKNA
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: AKNA_HUMAN, Q7Z591 (See
protein sequence)Recommended Name: AT-hook-containing transcription factor Size: 1439 amino acids; 155139 Da
Subcellular location: Nucleus
Sequence caution: Sequence=AAK83024.1; Type=Frameshift; Positions=1228; Sequence=AAU34192.1; Type=Frameshift; Positions=1227; Sequence=BAC85132.1; Type=Frameshift; Positions=1340; Sequence=BAD18725.1; Type=Frameshift; Positions=820, 1017, 1340, 1387, 1434;
Secondary accessions: Q05BK5 Q5T535 Q5T536 Q5T537 Q64FX6 Q64FX7 Q64FX8 Q64FY2 Q6ZMK0 Q6ZNL2 Q6ZTX0 Q8TET1 Q8TF33 Q96RR9 Q9H7P7Alternative splicing: 8 isoforms: Q7Z591-1 Q7Z591-2 Q7Z591-3 Q7Z591-4 Q7Z591-5 Q7Z591-6 Q7Z591-7 Q7Z591-8 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_110394.3
ENSEMBL proteins: ENSP00000223791 ENSP00000314538 ENSP00000363187 ENSP00000309222 ENSP00000378075 ENSP00000363188 ENSP00000378083 ENSP00000363201 ENSP00000303769 ENSP00000363192
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for AKNA: Assays for AKNA: | Protein
Domains/ Families for AKNA(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q7Z591 UniProtKB/Swiss-Prot: AKNA_HUMAN, Q7Z591Similarity: Contains 1 A.T hook DNA-binding domain | Gene Function for AKNA
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_030767
Applied Biosystems Silencer® siRNAs for AKNA
Sigma-Aldrich siRNA for AKNA  Sigma-Aldrich shRNA for AKNA  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_030767                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_030767                                  untagged cDNA clones in CMV expression vector (see all 2): NM_030767 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_030767
UniProtKB/Swiss-Prot: AKNA_HUMAN, Q7Z591Function: Transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | About this table | Pathways & Interactions for AKNA
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for AKNA (ENSP000003631923 Q7Z5912) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006350 | transcription |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | About this table
|
Drugs & Compounds for AKNA(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for AKNA
|
Transcripts for AKNA(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_030767
Sigma-Aldrich siRNA for AKNA  Sigma-Aldrich shRNA for AKNA  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_030767 REFSEQ mRNAs for AKNA gene: NM_030767.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_030767               OriGene GFP tagged cDNA clone in CMV expression vector: NM_030767                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_030767                                  untagged cDNA clones in CMV expression vector (see all 2): NM_030767  Additional cDNA sequence: AB075848.1 AF286341.1 AK024431.1 AK055563.1 AK074040.1 AK098036.1 AK131082.1 AK160382.1 AL833220.1 AY703039.1 AY703040.1 AY703041.1 AY703042.1 AY703043.1 AY703044.1 AY703045.1 AY703046.1 BC042202.1 BC055285.1 20 DOTS entries: DT.65286353 DT.99991191 DT.312555 DT.101984182 DT.97845363 DT.91883868 DT.86849275 DT.91797955 DT.121186626 DT.91712323 DT.91757913 DT.100751581 DT.95196176 DT.100751582 DT.86846849 DT.95272972 DT.99929870 DT.101984181 DT.91938389 DT.97803439 24/161 AceView cDNA sequences (see all 161
):AY703044 AB075848 CA432838 BM142077 AK024431 BF940396 CK819880 AI825795 BC042202 BC055285 BQ636860 AK126136 AL833220 BF057373 NM_030767 AY703043 CA433586 AY703040 AY703042 AK074040 AW502370 BX100125 AI217173 BG471175
highest scoring ESTs for AKNA:AK126136 BC055285 BU170540 T65933 AA363272 AA363273 AA452711 AA482620 AA495919 AA495920 Unigene Cluster for AKNA: AT-hook transcription factor Hs.494895 [show with all ESTs]Unigene Representative Sequence: NM_030767
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AKNA (see all 7
)
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | |
| SP1: | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for AKNA
10 Ensembl transcripts including schematic representations: ENST00000223791
ENST00000320310
ENST00000374074
ENST00000312033
ENST00000394574
ENST00000374075
ENST00000394582
ENST00000374088
ENST00000307564
ENST00000374079
|
Expression for AKNA
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| AKNA expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for AKNA
1 / 2 / 3 4 probe-sets matching AKNA gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CCTGAACTCT
SOURCE GeneReport for Unigene cluster: Hs.494895 UniProtKB/Swiss-Prot: AKNA_HUMAN, Q7Z591Tissue specificity: Predominantly expressed by lymphoid tissues. Highly expressed in the spleen, lymph nodes and peripheral blood leukocytes, expressed at lower level in the thymus. Mainly expressed by germinal center B-lymphocytes, a stage in which receptor and ligand interactions are crucial for B-lymphocyte maturation. Expressed by B- and T-lymphocytes, Natural killer cells and CD1a(+)CD14(-) but not CD1a(-)CD14(+) dendritic cells. Weakly or not expressed in fetal liver and in adult bone marrow |
Orthologs for AKNA
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AKNA gene from 3 species
About this table Species with no ortholog for AKNA
ENSEMBL Gene Tree for AKNA | Paralogs for AKNA(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for AKNA(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for AKNA (up to first 250kb)
|
Disorders & Mutations for AKNA
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605729
|
Medical News for AKNA(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for AKNA (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 8 PubMed articles for AKNA gene:- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)2, 3, 4 Nagase T....Ohara O. (2001)
- Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA. (PubMed id 11268217)2, 3, 4 Siddiqa A.... Martinez-Valdez H. (2001)
- The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation. (PubMed id 15869410)1, 3, 4 Sims-Mourtada J.C....Martinez-Valdez H. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)4 Humphray S.J.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for AKNA
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing AKNA
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing AKNA
(According to HUGE)
About This Section
| |
Specialized Databases showing AKNA(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for AKNA(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for AKNA:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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