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Aliases for AKNA Gene

Aliases for AKNA Gene

  • AT-Hook Transcription Factor 2 3
  • KIAA1968 4

External Ids for AKNA Gene

Previous GeneCards Identifiers for AKNA Gene

  • GC09M107896
  • GC09M108827
  • GC09M110552
  • GC09M112474
  • GC09M114177
  • GC09M116138
  • GC09M117096
  • GC09M086701

Summaries for AKNA Gene

GeneCards Summary for AKNA Gene

AKNA (AT-Hook Transcription Factor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AKNA Gene

  • Transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKNA Gene

Genomics for AKNA Gene

Regulatory Elements for AKNA Gene

Genomic Location for AKNA Gene

Start:
114,334,149 bp from pter
End:
114,398,503 bp from pter
Size:
64,355 bases
Orientation:
Minus strand

Genomic View for AKNA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKNA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKNA Gene

Proteins for AKNA Gene

  • Protein details for AKNA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z591-AKNA_HUMAN
    Recommended name:
    AT-hook-containing transcription factor
    Protein Accession:
    Q7Z591
    Secondary Accessions:
    • Q05BK5
    • Q5T535
    • Q5T536
    • Q5T537
    • Q64FX6
    • Q64FX7
    • Q64FX8
    • Q64FY2
    • Q6ZMK0
    • Q6ZNL2
    • Q6ZTX0
    • Q8TET1
    • Q8TF33
    • Q96RR9
    • Q9H7P7

    Protein attributes for AKNA Gene

    Size:
    1439 amino acids
    Molecular mass:
    155139 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK83024.1; Type=Frameshift; Positions=1228; Evidence={ECO:0000305}; Sequence=AAU34192.1; Type=Frameshift; Positions=1227; Evidence={ECO:0000305}; Sequence=BAB84866.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85554.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85132.1; Type=Frameshift; Positions=1340; Evidence={ECO:0000305}; Sequence=BAD18725.1; Type=Frameshift; Positions=820, 1017, 1340, 1387, 1434; Evidence={ECO:0000305};

    Alternative splice isoforms for AKNA Gene

neXtProt entry for AKNA Gene

Proteomics data for AKNA Gene at MOPED

Post-translational modifications for AKNA Gene

  • Ubiquitination at Lys1030
  • Modification sites at PhosphoSitePlus

Other Protein References for AKNA Gene

No data available for DME Specific Peptides for AKNA Gene

Domains for AKNA Gene

Protein Domains for AKNA Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z591

UniProtKB/Swiss-Prot:

AKNA_HUMAN :
  • Q7Z591
Domain:
  • Contains 1 A.T hook DNA-binding domain.
genes like me logo Genes that share domains with AKNA: view

No data available for Gene Families for AKNA Gene

Function for AKNA Gene

Molecular function for AKNA Gene

UniProtKB/Swiss-Prot Function: Transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters.

Gene Ontology (GO) - Molecular Function for AKNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 11268217
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 11268217
genes like me logo Genes that share ontologies with AKNA: view

Phenotypes for AKNA Gene

GenomeRNAi human phenotypes for AKNA:
genes like me logo Genes that share phenotypes with AKNA: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AKNA Gene

Localization for AKNA Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKNA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKNA Gene COMPARTMENTS Subcellular localization image for AKNA gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for AKNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with AKNA: view

Pathways for AKNA Gene

SuperPathways for AKNA Gene

No Data Available

Gene Ontology (GO) - Biological Process for AKNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 11268217
genes like me logo Genes that share ontologies with AKNA: view

No data available for Pathways by source for AKNA Gene

Transcripts for AKNA Gene

Unigene Clusters for AKNA Gene

AT-hook transcription factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKNA

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKNA Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1:
SP2: -
SP3:
SP4: - -
SP5:
SP6:
SP7: -

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for AKNA Gene

GeneLoc Exon Structure for
AKNA
ECgene alternative splicing isoforms for
AKNA

Expression for AKNA Gene

mRNA expression in normal human tissues for AKNA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AKNA Gene

This gene is overexpressed in Whole Blood (14.3) and Spleen (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKNA Gene

SOURCE GeneReport for Unigene cluster for AKNA Gene Hs.494895

mRNA Expression by UniProt/SwissProt for AKNA Gene

Q7Z591-AKNA_HUMAN
Tissue specificity: Predominantly expressed by lymphoid tissues. Highly expressed in the spleen, lymph nodes and peripheral blood leukocytes, expressed at lower level in the thymus. Mainly expressed by germinal center B-lymphocytes, a stage in which receptor and ligand interactions are crucial for B-lymphocyte maturation. Expressed by B- and T-lymphocytes, Natural killer cells and CD1a(+)CD14(-) but not CD1a(-)CD14(+) dendritic cells. Weakly or not expressed in fetal liver and in adult bone marrow.
genes like me logo Genes that share expressions with AKNA: view

In Situ Assay Products

Orthologs for AKNA Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKNA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKNA 35
  • 96.86 (n)
  • 95.92 (a)
AKNA 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AKNA 35
  • 79.76 (n)
  • 68.71 (a)
AKNA 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKNA 35
  • 79.91 (n)
  • 70.7 (a)
AKNA 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akna 35
  • 71.57 (n)
  • 60.19 (a)
Akna 16
Akna 36
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AKNA 36
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKNA 36
  • 32 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akna 35
  • 71.57 (n)
  • 59.26 (a)
lizard
(Anolis carolinensis)
Reptilia AKNA 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii AKNA 36
  • 23 (a)
OneToOne
Dr.16413 35
Species with no ortholog for AKNA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKNA Gene

ENSEMBL:
Gene Tree for AKNA (if available)
TreeFam:
Gene Tree for AKNA (if available)

Paralogs for AKNA Gene

No data available for Paralogs for AKNA Gene

Variants for AKNA Gene

Sequence variations from dbSNP and Humsavar for AKNA Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs726891 -- 114,350,927(-) CCTGC(C/T)GCTGC reference, synonymous-codon
rs726892 -- 114,350,900(-) CCAAC(A/G)GAGAC reference, synonymous-codon
rs902486 -- 114,340,988(+) acttc(A/G)gttac intron-variant
rs902487 -- 114,341,264(+) gctcc(A/C)agagg intron-variant
rs902488 -- 114,344,242(+) GGCAC(A/G)GGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKNA Gene

Variant ID Type Subtype PubMed ID
nsv893750 CNV Loss 21882294
dgv33e196 CNV Duplication 17116639
dgv948n27 CNV Gain 19166990
nsv893754 CNV Loss 21882294
nsv893757 CNV Gain 21882294
dgv949n27 CNV Gain 19166990
nsv471320 CNV Gain 18288195
nsv528823 CNV Gain 19592680
nsv509319 CNV Insertion 20534489
nsv893759 CNV Loss 21882294
esv22321 CNV Gain 19812545
nsv893764 CNV Gain 21882294
esv2752277 CNV Gain 17911159
esv2462819 CNV Deletion 19546169
nsv831693 CNV Gain 17160897

Relevant External Links for AKNA Gene

HapMap Linkage Disequilibrium report
AKNA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKNA Gene

Disorders for AKNA Gene

Relevant External Links for AKNA

Genetic Association Database (GAD)
AKNA
Human Genome Epidemiology (HuGE) Navigator
AKNA
genes like me logo Genes that share disorders with AKNA: view

No data available for UniProtKB/Swiss-Prot for AKNA Gene

Publications for AKNA Gene

  1. The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation. (PMID: 15869410) Sims-Mourtada J.C. … Martinez-Valdez H. (DNA Cell Biol. 2005) 3 4 23
  2. Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA. (PMID: 11268217) Siddiqa A. … Martinez-Valdez H. (Nature 2001) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. A polymorphism in the AT-hook motif of the transcriptional regulator AKNA is a risk factor for cervical cancer. (PMID: 20507260) Perales G. … Madrid-Marina V. (Biomarkers 2010) 3 48

Products for AKNA Gene

Sources for AKNA Gene

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