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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AKNA Gene

protein-coding   GIFtS: 50
GCID: GC09M117096

AT-hook transcription factor
 Explore 2 diseases affiliated with
AKNA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AKNA    

Aliases
for AKNA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
AT-Hook Transcription Factor1 2
KIAA19681 3
AKNA Transcript F22
AT-Hook Transcription Factor AKNA2
AT-Hook-Containing Transcription Factor2

External Ids:    HGNC: 241081   Entrez Gene: 807092   Ensembl: ENSG000001069487   OMIM: 6057295   UniProtKB: Q7Z5913   

Export aliases for AKNA gene to outside databases

Previous GC identifers: GC09M107896 GC09M108827 GC09M110552 GC09M112474 GC09M114177 GC09M116138 GC09M086701


Summaries
for AKNA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: AKNA_HUMAN, Q7Z591
Function: Transcription factor that specifically activates the expression of the CD40 receptor and its ligand
CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development.
Binds to A/T-rich promoters




Genomic Views
for AKNA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AKNA gene promoter:
         Max1   ER-alpha   AP-4   NF-E2 p45   c-Ets-1   MZF-1   PPAR-gamma1   PPAR-gamma2   NF-E2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AKNA promoter sequence
   Search SABiosciences Chromatin IP Primers for AKNA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKNA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q32

AKNA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKNA gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M117096:  view genomic region     (about GC identifiers)

Start:
 117,096,429 bp from pter      End:
 117,156,685 bp from pter
Size:
 60,257 bases      Orientation:
 minus strand

Proteins
for AKNA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AKNA_HUMAN, Q7Z591 (See protein sequence)
Recommended Name: AT-hook-containing transcription factor  
Size: 1439 amino acids; 155139 Da
Subcellular location: Nucleus
Sequence caution: Sequence=AAK83024.1; Type=Frameshift; Positions=1228; Sequence=AAU34192.1; Type=Frameshift;
Positions=1227; Sequence=BAB84866.1; Type=Erroneous initiation; Sequence=BAB85554.1; Type=Erroneous initiation;
Sequence=BAC85132.1; Type=Frameshift; Positions=1340; Sequence=BAD18725.1; Type=Frameshift; Positions=820, 1017, 1340,
1387, 1434;
Secondary accessions: Q05BK5 Q5T535 Q5T536 Q5T537 Q64FX6 Q64FX7 Q64FX8 Q64FY2 Q6ZMK0 Q6ZNL2 Q6ZTX0
Q8TET1 Q8TF33 Q96RR9 Q9H7P7
Alternative splicing: 8 isoforms:  Q7Z591-1   Q7Z591-2   Q7Z591-3   Q7Z591-4   Q7Z591-5   Q7Z591-6   Q7Z591-7   Q7Z591-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AKNA: NX_Q7Z591

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z591

    • AKNA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_110394.3  
    ENSEMBL proteins: 
     ENSP00000363201   ENSP00000223791   ENSP00000363188   ENSP00000309222   ENSP00000303769  
     ENSP00000363192  

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    Uscn Proteins for AKNA

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    AKNA for ontologies           About GeneDecksing



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    ThermoFisher Antibody for AKNA

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    Uscn ELISAs and CLIAs for AKNA

    Protein Domains /
    Families
    for AKNA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AKNA for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR022150 TF_AT-hook

    Graphical View of Domain Structure for InterPro Entry Q7Z591

    ProtoNet protein and cluster: Q7Z591

    UniProtKB/Swiss-Prot: AKNA_HUMAN, Q7Z591
    Similarity: Contains 1 A.T hook DNA-binding domain


    Function
    for AKNA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AKNA_HUMAN, Q7Z591
    Function: Transcription factor that specifically activates the expression of the CD40 receptor and its ligand
    CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development.
    Binds to A/T-rich promoters

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKNA
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate AKNA (see all 18):
    hsa-miR-579 hsa-miR-16-2* hsa-miR-300 hsa-miR-3121-3p hsa-miR-1827 hsa-miR-1286 hsa-miR-3163 hsa-miR-3671
    SwitchGear 3'UTR luciferase reporter plasmid: AKNA 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKNA (see all 6)
    OriGene siRNA: AKNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKNA

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKNA 

    Cell Line
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    Search LifeMap BioReagents cell lines for AKNA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKNA

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--


    AKNA for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for AKNA:
     G0/1 arrest  Increased G1 DNA content  Increased cell size 


    Pathways & Interactions
    for AKNA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AKNA

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for AKNA (Q7Z5912, 3 ENSP000003037694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GIGYF2Q6Y7W62, 3, ENSP000003871704MINT-65908 I2D: score=1 STRING: ENSP00000387170
    CD2BP2O954002, 3, ENSP000003049034MINT-62658 MINT-62647 I2D: score=1 STRING: ENSP00000304903
    WNK1Q9H4A33I2D: score=1 
    YWHAZP631043I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    AKNA for ontologies           About GeneDecksing



    Drugs & Compounds
    for AKNA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AKNA
    Search CenterWatch for drugs/clinical trials and news about AKNA 

    Transcripts
    for AKNA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AKNA gene: 
    NM_030767.4  

    Unigene Cluster for AKNA:

    AT-hook transcription factor
    Hs.494895  [show with all ESTs]
    Unigene Representative Sequence: NM_030767
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374088 ENST00000492875 ENST00000223791 ENST00000374075 ENST00000491133
    ENST00000490767 ENST00000312033(uc004biu.1 uc004biv.1 uc004biw.1)
    ENST00000307564(uc004bin.3 uc004bio.3 uc004bip.3 uc004biq.3 uc004bir.3 uc004bis.3 uc010mve.2)
    ENST00000374079

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKNA
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate AKNA (see all 18):
    hsa-miR-579 hsa-miR-16-2* hsa-miR-300 hsa-miR-3121-3p hsa-miR-1827 hsa-miR-1286 hsa-miR-3163 hsa-miR-3671
    SwitchGear 3'UTR luciferase reporter plasmid: AKNA 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKNA (see all 6)
    OriGene siRNA: AKNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKNA
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKNA (see all 2)
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    GenScript: all cDNA clones in your preferred vector: AKNA (NM_030767)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKNA 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKNA

    Additional cDNA sequence: 

    AB075848.1 AF286341.1 AK024431.1 AK055563.1 AK074040.1 AK098036.1 AK131082.2 AK160382.1 
    AL833220.1 AY703039.1 AY703040.1 AY703041.1 AY703042.1 AY703043.1 AY703044.1 AY703045.1 
    AY703046.1 BC042202.1 BC055285.1 

    20 DOTS entries:

    DT.65286353  DT.99991191  DT.312555  DT.101984182  DT.97845363  DT.91883868  DT.86849275  DT.91797955 
    DT.121186626  DT.91712323  DT.91757913  DT.100751581  DT.95196176  DT.100751582  DT.86846849  DT.95272972 
    DT.101984181  DT.91938389  DT.97803439  DT.99929870 

    24/161 AceView cDNA sequences (see all 161):

    CK819880 AK074040 AL833220 BQ636860 AY703044 BF940396 BF057373 BM142077 
    AY703040 AK024431 AY703042 AY703043 CA433586 AK126136 AB075848 BC042202 
    BC055285 AI825795 NM_030767 CA432838 BE551918 BF897373 BQ072666 BF985005 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AKNA (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                                                                                                                                                            
    SP2:                          -                                                                                                                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                            -     -                                                         
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for AKNA

    Expression
    for AKNA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AKNA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTGAACTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AKNA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See AKNA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AKNA

    SOURCE GeneReport for Unigene cluster: Hs.494895

    UniProtKB/Swiss-Prot: AKNA_HUMAN, Q7Z591
    Tissue specificity: Predominantly expressed by lymphoid tissues. Highly expressed in the spleen, lymph nodes and
    peripheral blood leukocytes, expressed at lower level in the thymus. Mainly expressed by germinal center
    B-lymphocytes, a stage in which receptor and ligand interactions are crucial for B-lymphocyte maturation. Expressed by
    B- and T-lymphocytes, Natural killer cells and CD1a(+)CD14(-) but not CD1a(-)CD14(+) dendritic cells. Weakly or not
    expressed in fetal liver and in adult bone marrow

        SABiosciences Custom PCR Arrays for AKNA
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKNA
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKNA

    Orthologs
    for AKNA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for AKNA gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Akna1 , 5 AT-hook transcription factor1, 5 71.81(n)1
    60.19(a)1    		   4 (33.96 cM)5
    1001821  NM_001045514.21  NP_001038979.11 
     633671255 
    lizard
    (Anolis carolinensis)    		 Reptilia AKNA6
    		 --
    		 47(a)
    		 1 ↔ 1
    		 GL344262.1(56727-68763)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.164132 Transcribed sequences 76.17(n)    BI562789.1 


    ENSEMBL Gene Tree for AKNA (if available)
    TreeFam Gene Tree for AKNA (if available) 

    Paralogs
    for AKNA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for AKNA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1223 NCBI SNPs in AKNA are shown (see all 1223)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2020197181,2
    		--117096126(+) GGCTC-/TGTGTCC 1 -- ds50010--------
    rs26368821,2
    		C,H,--117096742(+) ATGGAC/TGTGTT 1 -- ut3111Minor allele frequency- T:0.12NS EA NA CSA 672
    rs1459254451,2
    		--117096747(+) TGTGTC/TCTTAG 1 -- ut310--------
    rs1387917341,2
    		--117096750(+) GTTCTC/TAGGGT 1 -- ut310--------
    rs1867104331,2
    		--117096777(+) CAGAAG/TAAGGA 1 -- ut310--------
    rs1172716321,2
    		C,F,--117096790(+) TAACAC/AGTAAG 1 -- ut311Minor allele frequency- A:0.03NA 120
    rs1999650261,2
    		C--117096887(-) GGCTTG/TTGCCA 1 -- ut310--------
    rs1924375671,2
    		--117096895(+) GCCACA/GAAGGG 1 -- ut310--------
    rs1507848451,2
    		--117096902(+) AGGGCC/TGGCCT 1 -- ut310--------
    rs588648571,2
    		F,--117096903(+) GGGCCG/TGCCTC 1 -- ut311Minor allele frequency- T:0.26WA 118

    HapMap Linkage Disequilibrium report for AKNA (117096429 - 117156685 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for AKNA
         8 CNVs: 70782 53884 53071 100763 29804 5263 8632 5264

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKNA
    DNA2.0 Custom Variant and Variant Library Synthesis for AKNA

    Disorders / Diseases
    for AKNA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AKNA for disorders           About GeneDecksing

    OMIM gene information: 605729    OMIM disorders: --

    2 diseases for AKNA:    About MalaCards
    cervical cancer    cervicitis

    Human Genome Epidemiology (HuGE) Navigator: AKNA (4 documents)

    Export disorders for AKNA gene to outside databases

    Publications
    for AKNA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AKNA gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with AKNA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (2001)
    2. Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA. (PubMed id 11268217)1, 2, 3 Siddiqa A.... Martinez-Valdez H. (2001)
    3. The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation. (PubMed id 15869410)1, 2, 9 Sims-Mourtada J.C....Martinez-Valdez H. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Label-free proteomics reveals decreased expression of CD18 and AKNA in peripheral CD4+ T cells from patients with Vogt-Koyanagi-Hara da syndrome. (PubMed id 21297967)1 Mao L....Kijlstra A. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. A polymorphism in the AT-hook motif of the transcript ional regulator AKNA is a risk factor for cervical cancer. (PubMed id 20507260)1 Perales G....Madrid-Marina V. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    10. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)

    External Searches for AKNA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing AKNA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80709 HGNC: 24108 AceView: AKNA Ensembl:ENSG00000106948 euGenes: HUgn80709
    ECgene: AKNA H-InvDB: AKNA

    Other Databases showing AKNA gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1968

    Specialized Databases showing AKNA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AKNA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AKNA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AKNA gene:
    Search GeneIP for patents involving AKNA

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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