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AKNA Gene

protein-coding   GIFtS: 52
GCID: GC09M117096

AT-Hook Transcription Factor

  Search for AKNA
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
AT-Hook Transcription Factor1 2
AKNA Transcript F22
AT-Hook Transcription Factor AKNA2
AT-Hook-Containing Transcription Factor2
KIAA19683

External Ids:    HGNC: 241081   Entrez Gene: 807092   Ensembl: ENSG000001069487   OMIM: 6057295   UniProtKB: Q7Z5913   

Export aliases for AKNA gene to outside databases

Previous GC identifers: GC09M107896 GC09M108827 GC09M110552 GC09M112474 GC09M114177 GC09M116138 GC09M086701


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AKNA Gene:
AKNA (AT-hook transcription factor) is a protein-coding gene.

UniProtKB/Swiss-Prot: AKNA_HUMAN, Q7Z591
Function: Transcription factor that specifically activates the expression of the CD40 receptor and its ligand
CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell
development. Binds to A/T-rich promoters




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AKNA gene promoter:
         Max1   ER-alpha   AP-4   NF-E2 p45   c-Ets-1   MZF-1   PPAR-gamma1   PPAR-gamma2   NF-E2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AKNA promoter sequence
   Search Chromatin IP Primers for AKNA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKNA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q32

AKNA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKNA gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M117096:  view genomic region     (about GC identifiers)

Start:
117,096,429 bp from pter      End:
117,156,685 bp from pter
Size:
60,257 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AKNA_HUMAN, Q7Z591 (See protein sequence)
Recommended Name: AT-hook-containing transcription factor  
Size: 1439 amino acids; 155139 Da
Sequence caution: Sequence=AAK83024.1; Type=Frameshift; Positions=1228; Sequence=AAU34192.1; Type=Frameshift;
Positions=1227; Sequence=BAB84866.1; Type=Erroneous initiation; Sequence=BAB85554.1; Type=Erroneous initiation;
Sequence=BAC85132.1; Type=Frameshift; Positions=1340; Sequence=BAD18725.1; Type=Frameshift; Positions=820, 1017,
1340, 1387, 1434;
Secondary accessions: Q05BK5 Q5T535 Q5T536 Q5T537 Q64FX6 Q64FX7 Q64FX8 Q64FY2 Q6ZMK0 Q6ZNL2
Q6ZTX0 Q8TET1 Q8TF33 Q96RR9 Q9H7P7
Alternative splicing: 8 isoforms:  Q7Z591-1   Q7Z591-2   Q7Z591-3   Q7Z591-4   Q7Z591-5   Q7Z591-6   Q7Z591-7   Q7Z591-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AKNA: NX_Q7Z591

Explore proteomics data for AKNA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1030
  • Modification sites at PhosphoSitePlus

  • See AKNA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_110394.3  
    ENSEMBL proteins: 
     ENSP00000363201   ENSP00000223791   ENSP00000363188   ENSP00000309222   ENSP00000303769  
     ENSP00000363192  

    AKNA Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for AKNA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR022150 TF_AT-hook

    Graphical View of Domain Structure for InterPro Entry Q7Z591

    ProtoNet protein and cluster: Q7Z591

    UniProtKB/Swiss-Prot: AKNA_HUMAN, Q7Z591
    Similarity: Contains 1 A.T hook DNA-binding domain


    Find genes that share domains with AKNA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKNA_HUMAN, Q7Z591
    Function: Transcription factor that specifically activates the expression of the CD40 receptor and its ligand
    CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell
    development. Binds to A/T-rich promoters

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    Find genes that share ontologies with AKNA           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for AKNA:
     G0/1 arrest  Increased G1 DNA content  Increased cell size 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AKNA
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AKNA
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    hsa-miR-579 hsa-miR-16-2* hsa-miR-300 hsa-miR-3121-3p hsa-miR-1827 hsa-miR-1286 hsa-miR-3163 hsa-miR-3671
    SwitchGear 3'UTR luciferase reporter plasmidAKNA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AKNA

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKNA

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AKNA_HUMAN, Q7Z591: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with AKNA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AKNA
    Interactions:

        Search GeneGlobe Interaction Network for AKNA

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for AKNA (Q7Z5912, 3 ENSP000003037694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GIGYF2Q6Y7W62, 3, ENSP000003871704MINT-65908 I2D: score=1 STRING: ENSP00000387170
    CD2BP2O954002, 3, ENSP000003049034MINT-62658 MINT-62647 I2D: score=1 STRING: ENSP00000304903
    WNK1Q9H4A33I2D: score=1 
    YWHAZP631043I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with AKNA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AKNA



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AKNA gene: 
    NM_030767.4  

    Unigene Cluster for AKNA:

    AT-hook transcription factor
    Hs.494895  [show with all ESTs]
    Unigene Representative Sequence: NM_030767
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374088 ENST00000492875 ENST00000223791 ENST00000374075 ENST00000491133
    ENST00000490767 ENST00000312033(uc004biu.1 uc004biv.1 uc004biw.1)
    ENST00000307564(uc004bin.3 uc004bio.3 uc004bip.3 uc004biq.3 uc004bir.3 uc004bis.3 uc010mve.2)
    ENST00000374079
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AKNA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AKNA (see all 18):
    hsa-miR-579 hsa-miR-16-2* hsa-miR-300 hsa-miR-3121-3p hsa-miR-1827 hsa-miR-1286 hsa-miR-3163 hsa-miR-3671
    SwitchGear 3'UTR luciferase reporter plasmidAKNA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for AKNA
    Predesigned siRNA for gene silencing in human, mouse, rat AKNA
    Clone
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    OriGene ORF clones in mouse, rat for AKNA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AKNA (NM_030767)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKNA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKNA
    Primer
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    OriGene qPCR primer pairs and template standards for AKNA
    OriGene qSTAR qPCR primer pairs in human, mouse for AKNA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AKNA
      QuantiTect SYBR Green Assays in human, mouse, rat AKNA
      QuantiFast Probe-based Assays in human, mouse, rat AKNA

    Additional mRNA sequence: 

    AB075848.1 AF286341.1 AK024431.1 AK055563.1 AK074040.1 AK098036.1 AK131082.2 AK160382.1 
    AL833220.1 AY703039.1 AY703040.1 AY703041.1 AY703042.1 AY703043.1 AY703044.1 AY703045.1 
    AY703046.1 BC042202.1 BC055285.1 

    19 DOTS entries:

    DT.65286353  DT.99991191  DT.312555  DT.101984182  DT.97845363  DT.91883868  DT.86849275  DT.91797955 
    DT.121186626  DT.91757913  DT.100751581  DT.95196176  DT.100751582  DT.86846849  DT.95272972  DT.101984181 
    DT.91938389  DT.97803439  DT.99929870 

    Selected AceView cDNA sequences (see all 161):

    BC055285 AK074040 CA432838 BC042202 AY703044 BQ636860 BF940396 AI825795 
    BF057373 NM_030767 AL833220 CK819880 BM142077 AY703040 AK024431 AY703043 
    AY703042 CA433586 AK126136 AB075848 AW630962 BF515256 AW272682 BM707338 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AKNA (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                                                                                                                                                            
    SP2:                          -                                                                                                                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                            -     -                                                         
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for AKNA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AKNA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGAACTCT
    AKNA Expression
    About this image


    AKNA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SM30, NCr-fac & Meso-latp Progenitor
     
     Thymus (Hematopoietic System)
             Thymus
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             PureStem SM30, NCr-fac & Meso-latp Progenitor
    AKNA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKNA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.494895

    UniProtKB/Swiss-Prot: AKNA_HUMAN, Q7Z591
    Tissue specificity: Predominantly expressed by lymphoid tissues. Highly expressed in the spleen, lymph nodes and
    peripheral blood leukocytes, expressed at lower level in the thymus. Mainly expressed by germinal center
    B-lymphocytes, a stage in which receptor and ligand interactions are crucial for B-lymphocyte maturation.
    Expressed by B- and T-lymphocytes, Natural killer cells and CD1a(+)CD14(-) but not CD1a(-)CD14(+) dendritic
    cells. Weakly or not expressed in fetal liver and in adult bone marrow

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    QuantiFast Probe-based Assays in human, mouse, rat AKNA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKNA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AKNA gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akna1 , 5 AT-hook transcription factor1, 5 71.57(n)1
    60.19(a)1
      4 (33.96 cM)5
    1001821  NM_001045514.21  NP_001038979.11 
     633671255 
    lizard
    (Anolis carolinensis)
    Reptilia AKNA6
    AT-hook transcription factor
    47(a)
    1 ↔ 1
    GL344262.1(52670-70344)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.164132 Transcribed sequences 76.17(n)    BI562789.1 


    ENSEMBL Gene Tree for AKNA (if available)
    TreeFam Gene Tree for AKNA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AKNA (see all 1499)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3705104051,2
    C--117096511(+) GGGGAA/GGTTCA 1 -- ut310--------
    rs3741480421,2
    C--117096518(+) GTTCAA/GCATGT 1 -- ut310--------
    rs3678609001,2
    C--117096626(+) GCTGCC/TTGGGC 1 -- ut310--------
    rs26368821,2
    C,H--117096742(+) ATGGAC/TGTGTT 1 -- ut3111Minor allele frequency- T:0.12NS EA NA CSA 672
    rs1459254451,2
    C--117096747(+) TGTGTC/TCTTAG 1 -- ut310--------
    rs1387917341,2
    C--117096750(+) GTTCTC/TAGGGT 1 -- ut310--------
    rs1867104331,2
    --117096777(+) CAGAAG/TAAGGA 1 -- ut310--------
    rs1172716321,2
    C,F--117096790(+) TAACAC/AGTAAG 1 -- ut311Minor allele frequency- A:0.03NA 120
    rs1999650261,2
    C--117096887(-) GGCTTG/TTGCCA 1 -- ut310--------
    rs1924375671,2
    C--117096895(+) GCCACA/GAAGGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for AKNA (117096429 - 117156685 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AKNA (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2462819CNV Deletion19546169
    dgv33e196CNV Duplication17116639
    nsv509319CNV Insertion20534489
    nsv893750CNV Loss21882294
    nsv893754CNV Loss21882294
    nsv893759CNV Loss21882294
    dgv949n27CNV Gain19166990
    nsv471320CNV Gain18288195
    nsv528823CNV Gain19592680
    esv22321CNV Gain19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605729    OMIM disorders: --


    Find genes that share disorders with AKNA           About GenesLikeMe

    Genetic Association Database (GAD): AKNA
    Human Genome Epidemiology (HuGE) Navigator: AKNA (4 documents)

    Export disorders for AKNA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AKNA gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with AKNA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA. (PubMed id 11268217)1, 2, 3 Siddiqa A.... Martinez-Valdez H. (Nature 2001)
    3. The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation. (PubMed id 15869410)1, 2, 9 Sims-Mourtada J.C.... Martinez-Valdez H. (DNA Cell Biol. 2005)
    4. A polymorphism in the AT-hook motif of the transcriptional regulator AKNA is a risk factor for cervical cancer. (PubMed id 20507260)1, 4 Perales G....Madrid-Marina V. (Biomarkers 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Label-free proteomics reveals decreased expression of CD18 and AKNA in peripheral CD4+ T cells from patients with Vogt-Koyanagi-Harada syndrome. (PubMed id 21297967)1 Mao L....Kijlstra A. (PLoS ONE 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80709 HGNC: 24108 AceView: AKNA Ensembl:ENSG00000106948 euGenes: HUgn80709
    ECgene: AKNA H-InvDB: AKNA

    (According to HUGE)
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    HUGE: KIAA1968

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AKNA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AKNA gene:
    Search GeneIP for patents involving AKNA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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