AKIRIN2 Gene
protein-coding GIFtS: 44
GCID: GC06M088384
|
|
akirin 2(Previous name: chromosome 6 open reading frame 166 )
(Previous symbol: C6orf166)
| |
Aliases
for AKIRIN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Akirin 21 2 | | Chromosome 6 Open Reading Frame 1661 | | C6orf1661 2 3 | | FBI12 | | DJ486L4.21 | | Akirin-21 | | FLJ103421 | | Fourteen-Three-Three Beta Interactant 12 |
Export aliases for AKIRIN2 gene to outside databasesPrevious GC identifers: GC06M088442 GC06M085599 |
Summaries
for AKIRIN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AKIR2_HUMAN, Q53H80Function: Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to represstranscription of DUSP1 (By similarity)
Gene Wiki entry for AKIRIN2 (C6orf166)
|
Genomic Views
for AKIRIN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007299.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AKIRIN2 gene promoter:
Bach1 Egr-3 Sox5 AML1a Sp1 MEF-2A aMEF-2 ITF-2 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for AKIRIN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKIRIN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q15 Ensembl cytogenetic band: 6q15 HGNC cytogenetic band: 6q15AKIRIN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M088384: view genomic region
(about GC identifiers)
Start:
|
88,384,578 bp from pter |
End:
|
88,411,985 bp from pter |
Size:
|
27,408 bases |
Orientation:
|
minus strand |
|
Proteins
for AKIRIN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AKIR2_HUMAN, Q53H80 (See
protein sequence)Recommended Name: Akirin-2 Size: 203 amino acids; 22496 Da
Subunit: Interacts with YWHAB (By similarity)
Subcellular location: Nucleus
Miscellaneous: 'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence ofthe clear nuclear localization signal
Secondary accessions: Q9BQB1Explore the universe of human proteins at neXtProt for AKIRIN2: NX_Q53H80
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q53H80
AKIRIN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060534.1
ENSEMBL proteins: ENSP00000257787
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
AKIRIN2 for ontologies About GeneDecksing
AKIRIN2 Antibody Products:
Assay Products for AKIRIN2: |
Protein
Domains /
Families
for AKIRIN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AKIRIN2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q53H80ProtoNet protein and cluster: Q53H80 UniProtKB/Swiss-Prot: AKIR2_HUMAN, Q53H80Similarity: Belongs to the akirin family |
Function
for AKIRIN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AKIR2_HUMAN, Q53H80Function: Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to represstranscription of DUSP1 (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKIRIN2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKIRIN2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: AKIRIN2 (NM_018064) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AKIRIN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKIRIN2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKIRIN2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- | | GO:0016566 | specific transcriptional repressor activity |
-- | -- |
AKIRIN2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Akirin2tm1.1Aki for AKIRIN2
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Akirin2):
AKIRIN2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for AKIRIN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AKIRIN2
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for AKIRIN2 (Q53H803 ENSP000002577874) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0008284 | positive regulation of cell proliferation |
IEA | -- | | GO:0009790 | embryo development |
IEA | -- | | GO:0010950 | positive regulation of endopeptidase activity |
IEA | -- |
AKIRIN2 for ontologies About GeneDecksing
|
Drugs & Compounds
for AKIRIN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AKIRIN2
Search CenterWatch for drugs/clinical trials and news about AKIRIN2 / AKIR2
|
Transcripts
for AKIRIN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AKIRIN2 gene: NM_018064.3 Unigene Cluster for AKIRIN2: Akirin 2 Hs.485915 [show with all ESTs]Unigene Representative Sequence: NM_0180641 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000257787(uc003pmk.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKIRIN2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKIRIN2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AKIRIN2 (NM_018064) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AKIRIN2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKIRIN2 |
Additional cDNA sequence: AK001204.1 AK222701.1 BC000764.2 BC003042.1 BC005051.1 10 DOTS entries: DT.100790814 DT.444774 DT.95273863 DT.100737395 DT.100034660 DT.121392163 DT.403850 DT.100790815 DT.101954924 DT.95273864 24/209 AceView cDNA sequences (see all 209): BU623266 CD365805 CD675535 BF003135 BQ051282 AA825829 AI799599 CK904630 AW206106 AI073802 BF434853 AI361657 BM054755 AI246734 CR599380 BM726867 AW137599 CF130567 AW173067 AI808291 AW138069 AI457744 AA837372 BM713051
GeneLoc Exon Structure
|
Expression
for AKIRIN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AKIRIN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTTCACTG
About this image
See AKIRIN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AKIRIN2
SOURCE GeneReport for Unigene cluster: Hs.485915
UniProtKB/Swiss-Prot: AKIR2_HUMAN, Q53H80Tissue specificity: Widely expressed with the highest expression in peripheral blood leukocytes
SABiosciences Custom PCR Arrays for AKIRIN2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKIRIN2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AKIRIN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKIRIN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKIRIN2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKIRIN2 |
Orthologs
for AKIRIN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for AKIRIN2 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for AKIRIN2 (if available)
TreeFam Gene Tree for AKIRIN2 (if available) |
Paralogs
for AKIRIN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AKIRIN2 gene
- AKIRIN12
1 SIMAP similar gene for AKIRIN2 using alignment to 1 protein entry: AKIR2_HUMAN:AKIRIN1
AKIRIN2 for paralogs About GeneDecksing
|
Genomic Variants
for AKIRIN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AKIRIN2 (88384578 - 88411985 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for AKIRIN2
3 CNVs: 3627 31296 93881 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKIRIN2 |
|
Disorders
/ Diseases
for AKIRIN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for AKIRIN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AKIRIN2 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with AKIRIN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Akirins are highly conserved nuclear proteins required for NF-kappaB- dependent gene expression in Drosophila and mice. (PubMed id 18066067)1, 2 Goto A.... Reichhart J.-M. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis. (PubMed id 18460465)1 Komiya Y....Tashiro F. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
|
External Searches for AKIRIN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AKIRIN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AKIRIN2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AKIRIN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AKIRIN2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for AKIRIN2 gene:
Search GeneIP for patents involving AKIRIN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AKIRIN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for AKIRIN2 | | OriGene shRNA RFP for AKIRIN2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKIRIN2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKIRIN2 | | | OriGene Protein Over-expression Lysate for AKIRIN2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AKIRIN2 | | OriGene 3'-UTR Clone for AKIRIN2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKIRIN2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKIRIN2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for AKIRIN2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AKIRIN2 | | OriGene Custom Protein Services for AKIRIN2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AKIRIN2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKIRIN2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKIRIN2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKIRIN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKIRIN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKIRIN2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for AKIRIN2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | AKIRIN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKIRIN2 |
|  |  |  | | | | ThermoFisher Antibodies for AKIRIN2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKIRIN2 |
|
|
|
|
