Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AKIRIN2 Gene

Aliases for AKIRIN2 Gene

  • Akirin 2 2 3
  • C6orf166 3 4
  • Fourteen-Three-Three Beta Interactant 1 3
  • Chromosome 6 Open Reading Frame 166 2
  • DJ486L4.2 3
  • Akirin-2 3
  • FBI1 3

External Ids for AKIRIN2 Gene

Previous HGNC Symbols for AKIRIN2 Gene

  • C6orf166

Previous GeneCards Identifiers for AKIRIN2 Gene

  • GC06M088442
  • GC06M085599
  • GC06M088384

Summaries for AKIRIN2 Gene

GeneCards Summary for AKIRIN2 Gene

AKIRIN2 (Akirin 2) is a Protein Coding gene. An important paralog of this gene is AKIRIN1.

UniProtKB/Swiss-Prot for AKIRIN2 Gene

  • Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).

Gene Wiki entry for AKIRIN2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKIRIN2 Gene

Genomics for AKIRIN2 Gene

Regulatory Elements for AKIRIN2 Gene

Genomic Location for AKIRIN2 Gene

Start:
87,674,860 bp from pter
End:
87,702,267 bp from pter
Size:
27,408 bases
Orientation:
Minus strand

Genomic View for AKIRIN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKIRIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKIRIN2 Gene

Proteins for AKIRIN2 Gene

  • Protein details for AKIRIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53H80-AKIR2_HUMAN
    Recommended name:
    Akirin-2
    Protein Accession:
    Q53H80
    Secondary Accessions:
    • Q9BQB1

    Protein attributes for AKIRIN2 Gene

    Size:
    203 amino acids
    Molecular mass:
    22496 Da
    Quaternary structure:
    • Interacts with YWHAB.
    Miscellaneous:
    • Akiraka ni suru means making things clear in Japanese. The name is given based on the presence of the clear nuclear localization signal

neXtProt entry for AKIRIN2 Gene

Proteomics data for AKIRIN2 Gene at MOPED

Post-translational modifications for AKIRIN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKIRIN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AKIRIN2 Gene

Domains for AKIRIN2 Gene

Protein Domains for AKIRIN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AKIRIN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53H80

UniProtKB/Swiss-Prot:

AKIR2_HUMAN :
  • Q53H80
Family:
  • Belongs to the akirin family.
genes like me logo Genes that share domains with AKIRIN2: view

No data available for Gene Families for AKIRIN2 Gene

Function for AKIRIN2 Gene

Molecular function for AKIRIN2 Gene

UniProtKB/Swiss-Prot Function: Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).

Gene Ontology (GO) - Molecular Function for AKIRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019899 enzyme binding IPI 23382074
genes like me logo Genes that share ontologies with AKIRIN2: view

Phenotypes for AKIRIN2 Gene

genes like me logo Genes that share phenotypes with AKIRIN2: view

Animal Models for AKIRIN2 Gene

MGI Knock Outs for AKIRIN2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKIRIN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for AKIRIN2 Gene

Localization for AKIRIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKIRIN2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKIRIN2 Gene COMPARTMENTS Subcellular localization image for AKIRIN2 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AKIRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18066067
GO:0017053 transcriptional repressor complex ISS --
genes like me logo Genes that share ontologies with AKIRIN2: view

Pathways for AKIRIN2 Gene

SuperPathways for AKIRIN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AKIRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0009790 embryo development IEA --
GO:0010629 negative regulation of gene expression --
genes like me logo Genes that share ontologies with AKIRIN2: view

No data available for Pathways by source for AKIRIN2 Gene

Transcripts for AKIRIN2 Gene

mRNA/cDNA for AKIRIN2 Gene

Unigene Clusters for AKIRIN2 Gene

Akirin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKIRIN2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKIRIN2 Gene

No ASD Table

Relevant External Links for AKIRIN2 Gene

GeneLoc Exon Structure for
AKIRIN2
ECgene alternative splicing isoforms for
AKIRIN2

Expression for AKIRIN2 Gene

mRNA expression in normal human tissues for AKIRIN2 Gene

mRNA differential expression in normal tissues according to GTEx for AKIRIN2 Gene

This gene is overexpressed in Whole Blood (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKIRIN2 Gene

SOURCE GeneReport for Unigene cluster for AKIRIN2 Gene Hs.485915

mRNA Expression by UniProt/SwissProt for AKIRIN2 Gene

Q53H80-AKIR2_HUMAN
Tissue specificity: Widely expressed with the highest expression in peripheral blood leukocytes.
genes like me logo Genes that share expressions with AKIRIN2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for AKIRIN2 Gene

Orthologs for AKIRIN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AKIRIN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKIRIN2 35
  • 99.67 (n)
  • 100 (a)
AKIRIN2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AKIRIN2 35
  • 94.75 (n)
  • 97.54 (a)
AKIRIN2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKIRIN2 35
  • 95.89 (n)
  • 98.03 (a)
AKIRIN2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akirin2 35
  • 90.05 (n)
  • 93.03 (a)
Akirin2 16
Akirin2 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AKIRIN2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKIRIN2 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akirin2 35
  • 89.39 (n)
  • 93.03 (a)
chicken
(Gallus gallus)
Aves AKIRIN2 35
  • 87.09 (n)
  • 93.19 (a)
AKIRIN2 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKIRIN2 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7326 35
tropical clawed frog
(Silurana tropicalis)
Amphibia akirin2 35
  • 79.44 (n)
  • 85.56 (a)
MGC76154 35
zebrafish
(Danio rerio)
Actinopterygii akirin2 35
  • 72.59 (n)
  • 82.22 (a)
akirin2 36
  • 82 (a)
OneToOne
Dr.4764 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006809 35
  • 53.98 (n)
  • 46.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta akirin 35
  • 48.05 (n)
  • 40.1 (a)
akirin 36
  • 39 (a)
OneToMany
Species with no ortholog for AKIRIN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKIRIN2 Gene

ENSEMBL:
Gene Tree for AKIRIN2 (if available)
TreeFam:
Gene Tree for AKIRIN2 (if available)

Paralogs for AKIRIN2 Gene

Paralogs for AKIRIN2 Gene

Selected SIMAP similar genes for AKIRIN2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AKIRIN2: view

Variants for AKIRIN2 Gene

Sequence variations from dbSNP and Humsavar for AKIRIN2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs9474 -- 87,702,050(+) CTGAG(A/C/G/T)CTAGA utr-variant-5-prime
rs11666 -- 87,681,659(-) ATGCA(C/T)AGCCA reference, stop-gained
rs1052623 -- 87,702,172(-) GCAGC(C/T)ACCTC utr-variant-5-prime
rs2246113 -- 87,700,332(+) ACTTC(A/G)GTTTT intron-variant
rs2250276 -- 87,688,037(-) tttct(A/G)cctca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKIRIN2 Gene

Variant ID Type Subtype PubMed ID
dgv1992e1 CNV Complex 17122850
nsv7941 CNV Gain 18304495

Relevant External Links for AKIRIN2 Gene

HapMap Linkage Disequilibrium report
AKIRIN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKIRIN2 Gene

Disorders for AKIRIN2 Gene

No disorders were found for AKIRIN2 Gene.

No data available for UniProtKB/Swiss-Prot for AKIRIN2 Gene

Publications for AKIRIN2 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  2. Akirins are highly conserved nuclear proteins required for NF-kappaB- dependent gene expression in Drosophila and mice. (PMID: 18066067) Goto A. … Reichhart J.-M. (Nat. Immunol. 2008) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for AKIRIN2 Gene

Sources for AKIRIN2 Gene

Back to Top

Content