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AKIRIN2 Gene

protein-coding   GIFtS: 46
GCID: GC06M088384

Akirin 2

(Previous name: chromosome 6 open reading frame 166)
(Previous symbol: C6orf166)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Akirin 21 2     akirin-22
C6orf1661 2 3     dJ486L4.22
Chromosome 6 Open Reading Frame 1661     Fourteen-Three-Three Beta Interactant 12
FBI12     

External Ids:    HGNC: 214071   Entrez Gene: 551222   Ensembl: ENSG000001353347   OMIM: 6151655   UniProtKB: Q53H803   

Export aliases for AKIRIN2 gene to outside databases

Previous GC identifers: GC06M088442 GC06M085599


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AKIRIN2 Gene:
AKIRIN2 (akirin 2) is a protein-coding gene. An important paralog of this gene is AKIRIN1.

UniProtKB/Swiss-Prot: AKIR2_HUMAN, Q53H80
Function: Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and
IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress
transcription of DUSP1 (By similarity)

Gene Wiki entry for AKIRIN2 (C6orf166) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the AKIRIN2 gene promoter:
         Bach1   Egr-3   Sox5   AML1a   Sp1   MEF-2A   aMEF-2   ITF-2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAKIRIN2 promoter sequence
   Search Chromatin IP Primers for AKIRIN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKIRIN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q15   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q15

AKIRIN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKIRIN2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M088384:  view genomic region     (about GC identifiers)

Start:
88,384,578 bp from pter      End:
88,411,985 bp from pter
Size:
27,408 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AKIR2_HUMAN, Q53H80 (See protein sequence)
Recommended Name: Akirin-2  
Size: 203 amino acids; 22496 Da
Subunit: Interacts with YWHAB (By similarity)
Miscellaneous: 'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence
of the clear nuclear localization signal
Secondary accessions: Q9BQB1

Explore the universe of human proteins at neXtProt for AKIRIN2: NX_Q53H80

Explore proteomics data for AKIRIN2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AKIRIN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060534.1  
    ENSEMBL proteins: 
     ENSP00000257787  

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    antibodies-online proteins for AKIRIN2 (5 products) 

     
    antibodies-online peptides for AKIRIN2

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    antibodies-online antibodies for AKIRIN2 (46 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR024132 Akirin

    Graphical View of Domain Structure for InterPro Entry Q53H80

    ProtoNet protein and cluster: Q53H80

    UniProtKB/Swiss-Prot: AKIR2_HUMAN, Q53H80
    Similarity: Belongs to the akirin family


    Find genes that share domains with AKIRIN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKIR2_HUMAN, Q53H80
    Function: Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and
    IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress
    transcription of DUSP1 (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with AKIRIN2           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Akirin2):
     mortality/aging  no phenotypic analysis 

    Find genes that share phenotypes with AKIRIN2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Akirin2tm1.1Aki for AKIRIN2

       genOway: Develop your customized and physiologically relevant rodent model for AKIRIN2

    miRNA
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    Block miRNA regulation of human, mouse, rat AKIRIN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AKIRIN2 (see all 41):
    hsa-miR-140-5p hsa-miR-100* hsa-miR-4307 hsa-miR-513a-5p hsa-miR-139-5p hsa-miR-624 hsa-miR-301a hsa-miR-500a
    SwitchGear 3'UTR luciferase reporter plasmidAKIRIN2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AKIRIN2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AKIR2_HUMAN, Q53H80: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    extracellular1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18066067
    GO:0017053transcriptional repressor complex ISS--

    Find genes that share ontologies with AKIRIN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AKIRIN2
    Interactions:

        Search GeneGlobe Interaction Network for AKIRIN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for AKIRIN2 (Q53H803 ENSP000002577874) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158343, ENSP000003116954I2D: score=4 STRING: ENSP00000311695
    LNX1Q8TBB13, ENSP000002639254I2D: score=4 STRING: ENSP00000263925
    SPG21Q9NZD83, ENSP000002045664I2D: score=4 STRING: ENSP00000204566
    MPDZENSP000003704104STRING: ENSP00000370410
    UBE2HENSP000003478364STRING: ENSP00000347836
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0009790embryo development IEA--
    GO:0010629negative regulation of gene expression ----

    Find genes that share ontologies with AKIRIN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AKIRIN2 (AKIR2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AKIRIN2 gene: 
    NM_018064.3  

    Unigene Cluster for AKIRIN2:

    Akirin 2
    Hs.485915  [show with all ESTs]
    Unigene Representative Sequence: NM_018064
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257787(uc003pmk.3) ENST00000420494(uc021zcn.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate AKIRIN2 (see all 41):
    hsa-miR-140-5p hsa-miR-100* hsa-miR-4307 hsa-miR-513a-5p hsa-miR-139-5p hsa-miR-624 hsa-miR-301a hsa-miR-500a
    SwitchGear 3'UTR luciferase reporter plasmidAKIRIN2 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKIRIN2
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AKIRIN2
      QuantiTect SYBR Green Assays in human, mouse, rat AKIRIN2
      QuantiFast Probe-based Assays in human, mouse, rat AKIRIN2

    Additional mRNA sequence: 

    AK001204.1 AK222701.1 BC000764.2 BC003042.1 BC005051.1 

    10 DOTS entries:

    DT.100790814  DT.444774  DT.95273863  DT.100737395  DT.100034660  DT.121392163  DT.403850  DT.100790815 
    DT.101954924  DT.95273864 

    Selected AceView cDNA sequences (see all 209):

    CR624811 BF195695 AI686237 AW072464 BM129089 BM716938 AI436412 AI367166 
    AI073802 AW206106 AW138069 AI808291 AW173067 CF130567 AW137599 AI361657 
    BM726867 AI246734 CR599380 BM054755 BF434853 CD365805 BF003135 CD675535 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AKIRIN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTTCACTG
    AKIRIN2 Expression
    About this image

    AKIRIN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKIRIN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485915

    UniProtKB/Swiss-Prot: AKIR2_HUMAN, Q53H80
    Tissue specificity: Widely expressed with the highest expression in peripheral blood leukocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AKIRIN2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akirin21 , 5 akirin 21, 5 90.05(n)1
    93.03(a)1
      4 (16.80 cM)5
    4336931  NM_001007589.31  NP_001007590.21 
     345509375 
    chicken
    (Gallus gallus)
    Aves AKIRIN21 akirin 2 87.09(n)
    93.19(a)
      421821  NM_001193595.1  NP_001180524.1 
    lizard
    (Anolis carolinensis)
    Reptilia AKIRIN26
    akirin 2
    88(a)
    1 ↔ 1
    1(176256051-176274266)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.73262 Xenopus laevis transcribed sequence with moderate similarity more 80.54(n)    BU903044.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.47642 Danio rerio mRNA similar to hypothetical protein FLJ1 more 73.87(n)    BC045294.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta akirin1 akirin 48.05(n)
    40.1(a)
      38821  NM_168211.3  NP_729249.1 


    ENSEMBL Gene Tree for AKIRIN2 (if available)
    TreeFam Gene Tree for AKIRIN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AKIRIN2 gene
    AKIRIN12  
    1 SIMAP similar gene for AKIRIN2 using alignment to 1 protein entry:     AKIR2_HUMAN:
    AKIRIN1

    Find genes that share paralogs with AKIRIN2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AKIRIN2 (see all 638)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs765338451,2
    F--88384087(+) TTTAAG/CATTGT 1 -- int11Minor allele frequency- C:0.09WA 118
    rs1884860071,2
    --88384111(+) AATATG/TCTACT 1 -- int10--------
    rs1159932361,2
    F--88384267(+) CTACTG/AATATC 1 -- int11Minor allele frequency- A:0.06WA 118
    rs94507681,2
    --88384362(+) tatatA/Tttttt 1 -- int10--------
    rs77752261,2
    C,F,A,H--88384530(+) TGAAAC/TAGCAC 1 -- int112Minor allele frequency- T:0.04NS EA NA WA 1660
    rs1406685471,2
    C--88384581(+) GCTTAC/TGTTTT 1 -- ut310--------
    rs344074871,2
    C--88384713(+) AAAAAA/-TGCAG 1 -- ut313Minor allele frequency- -:0.17NA CSA 6
    rs32106361,2
    F--88384773(+) aactaC/Aaaaaa 1 -- ut311Minor allele frequency- A:0.09MN 184
    rs1816327491,2
    --88384851(+) TTCACA/TATTTC 1 -- ut310--------
    rs77614531,2
    C,F,H--88384877(+) GGCTAT/CTTGCT 1 -- ut3110Minor allele frequency- C:0.06NS EA NA WA 1308

    HapMap Linkage Disequilibrium report for AKIRIN2 (88384578 - 88411985 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AKIRIN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7941CNV Gain18304495
    dgv1992e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AKIRIN2
    DNA2.0 Custom Variant and Variant Library Synthesis for AKIRIN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615165    OMIM disorders: --


    Find genes that share disorders with AKIRIN2           About GenesLikeMe


    Export disorders for AKIRIN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AKIRIN2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with AKIRIN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Akirins are highly conserved nuclear proteins required for NF-kappaB- dependent gene expression in Drosophila and mice. (PubMed id 18066067)1, 2 Goto A.... Reichhart J.-M. (Nat. Immunol. 2008)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)1 Armour S.M....Sinclair D.A. (Mol. Cell. Biol. 2013)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55122 HGNC: 21407 AceView: C6orf166 Ensembl:ENSG00000135334 euGenes: HUgn55122
    ECgene: AKIRIN2 H-InvDB: AKIRIN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AKIRIN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AKIRIN2 gene:
    Search GeneIP for patents involving AKIRIN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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