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Aliases for AKIRIN1 Gene

Aliases for AKIRIN1 Gene

  • Akirin 1 2 3 5
  • C1orf108 3 4
  • Chromosome 1 Open Reading Frame 108 2
  • Akirin-1 3
  • STRF2 3

External Ids for AKIRIN1 Gene

Previous HGNC Symbols for AKIRIN1 Gene

  • C1orf108

Previous GeneCards Identifiers for AKIRIN1 Gene

  • GC01P039230
  • GC01P039456
  • GC01P037576

Summaries for AKIRIN1 Gene

GeneCards Summary for AKIRIN1 Gene

AKIRIN1 (Akirin 1) is a Protein Coding gene. An important paralog of this gene is AKIRIN2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKIRIN1 Gene

Genomics for AKIRIN1 Gene

Regulatory Elements for AKIRIN1 Gene

Enhancers for AKIRIN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G039016 0.8 ENCODE 19.2 +25.7 25705 1.5 ELF3 FOXA2 ARID4B RAD21 THRB ZSCAN9 RARA FOS EGR2 CEBPB NDUFS5 AKIRIN1 KIAA0754 MACF1 GJA9 MYCBP PIR42637
GH01G039097 1.3 Ensembl ENCODE dbSUPER 10.7 +107.4 107431 1.4 RB1 ARID4B BMI1 ZNF2 RAD21 RFX5 YY1 GLIS2 ZNF143 RCOR1 RNU6-608P ENSG00000226438 AKIRIN1 OXCT2P1 GJA9 MYCBP MACF1 KIAA0754 GC01M039121
GH01G038989 1.4 ENCODE dbSUPER 9.6 +0.0 49 4.0 HDGF FOXA2 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 NDUFS5 RHBDL2 GJA9 MYCBP UTP11 AKIRIN1 PIR42637
GH01G039025 1.1 ENCODE 11.5 +35.3 35343 2.4 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 NDUFS5 MYCBP LOC101929516 AKIRIN1 SNORA55 GJA9 RRAGC PPIEL LOC105378663 GC01M038902
GH01G038961 1 Ensembl ENCODE 12.2 -29.2 -29224 1.9 ELF3 SOX13 KLF1 FOXA2 SAP130 ARID4B ZNF384 SALL2 CEBPG ZNF644 RHBDL2 AKIRIN1 GJA9 MYCBP NDUFS5 EIF1P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AKIRIN1 on UCSC Golden Path with GeneCards custom track

Promoters for AKIRIN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004995 577 2401 HDGF FOXA2 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207

Genomic Location for AKIRIN1 Gene

Chromosome:
1
Start:
38,991,223 bp from pter
End:
39,006,065 bp from pter
Size:
14,843 bases
Orientation:
Plus strand

Genomic View for AKIRIN1 Gene

Genes around AKIRIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKIRIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKIRIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKIRIN1 Gene

Proteins for AKIRIN1 Gene

  • Protein details for AKIRIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9L7-AKIR1_HUMAN
    Recommended name:
    Akirin-1
    Protein Accession:
    Q9H9L7
    Secondary Accessions:
    • B4DZU6
    • Q0VDB3
    • Q53FK8

    Protein attributes for AKIRIN1 Gene

    Size:
    192 amino acids
    Molecular mass:
    21867 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Akiraka ni suru means making things clear in Japanese. The name is given based on the presence of the clear nuclear localization signal.
    SequenceCaution:
    • Sequence=AAI19747.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AKIRIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKIRIN1 Gene

Post-translational modifications for AKIRIN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKIRIN1 Gene

No data available for DME Specific Peptides for AKIRIN1 Gene

Domains & Families for AKIRIN1 Gene

Protein Domains for AKIRIN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AKIRIN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H9L7

UniProtKB/Swiss-Prot:

AKIR1_HUMAN :
  • Belongs to the akirin family.
Family:
  • Belongs to the akirin family.
genes like me logo Genes that share domains with AKIRIN1: view

No data available for Gene Families for AKIRIN1 Gene

Function for AKIRIN1 Gene

Gene Ontology (GO) - Molecular Function for AKIRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with AKIRIN1: view
genes like me logo Genes that share phenotypes with AKIRIN1: view

Animal Models for AKIRIN1 Gene

MGI Knock Outs for AKIRIN1:

Animal Model Products

CRISPR Products

miRNA for AKIRIN1 Gene

miRTarBase miRNAs that target AKIRIN1

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AKIRIN1 Gene

Localization for AKIRIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKIRIN1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKIRIN1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for AKIRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 18066067
GO:0005654 nucleoplasm IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with AKIRIN1: view

Pathways & Interactions for AKIRIN1 Gene

SuperPathways for AKIRIN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AKIRIN1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AKIRIN1 Gene

Drugs & Compounds for AKIRIN1 Gene

No Compound Related Data Available

Transcripts for AKIRIN1 Gene

Unigene Clusters for AKIRIN1 Gene

Akirin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKIRIN1 Gene

No ASD Table

Relevant External Links for AKIRIN1 Gene

GeneLoc Exon Structure for
AKIRIN1
ECgene alternative splicing isoforms for
AKIRIN1

Expression for AKIRIN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AKIRIN1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AKIRIN1 Gene



NURSA nuclear receptor signaling pathways regulating expression of AKIRIN1 Gene:

AKIRIN1

SOURCE GeneReport for Unigene cluster for AKIRIN1 Gene:

Hs.293563

mRNA Expression by UniProt/SwissProt for AKIRIN1 Gene:

Q9H9L7-AKIR1_HUMAN
Tissue specificity: Widely expressed with the highest expression in heart, liver, placenta and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for AKIRIN1 Gene

  • Nervous system(4)
  • Muscle(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with AKIRIN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKIRIN1 Gene

Orthologs for AKIRIN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for AKIRIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKIRIN1 34
  • 99.83 (n)
cow
(Bos Taurus)
Mammalia AKIRIN1 34 35
  • 95.14 (n)
dog
(Canis familiaris)
Mammalia AKIRIN1 34 35
  • 92.53 (n)
rat
(Rattus norvegicus)
Mammalia Akirin1 34
  • 89.01 (n)
mouse
(Mus musculus)
Mammalia Akirin1 34 16 35
  • 88.13 (n)
oppossum
(Monodelphis domestica)
Mammalia AKIRIN1 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKIRIN1 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia akirin1 34
  • 74.2 (n)
Str.16846 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4204 34
zebrafish
(Danio rerio)
Actinopterygii akirin1 34 35
  • 66.67 (n)
wufa96c11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1697 34
fruit fly
(Drosophila melanogaster)
Insecta akirin 35
  • 33 (a)
OneToMany
Species where no ortholog for AKIRIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKIRIN1 Gene

ENSEMBL:
Gene Tree for AKIRIN1 (if available)
TreeFam:
Gene Tree for AKIRIN1 (if available)

Paralogs for AKIRIN1 Gene

Paralogs for AKIRIN1 Gene

(1) SIMAP similar genes for AKIRIN1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for AKIRIN1 Gene

genes like me logo Genes that share paralogs with AKIRIN1: view

Variants for AKIRIN1 Gene

Sequence variations from dbSNP and Humsavar for AKIRIN1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000015835 -- 38,997,032(+) GTAAA(G/T)ATCCT intron-variant
rs1000620110 -- 38,990,094(+) TCCAC(-/A)AGGAG upstream-variant-2KB
rs1000827724 -- 38,994,453(+) CTGAT(C/T)ATGAC intron-variant
rs1001049762 -- 38,989,826(+) TTACA(G/T)TCTTG upstream-variant-2KB
rs1001262162 -- 39,002,025(+) AAAGA(A/C/G)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKIRIN1 Gene

Variant ID Type Subtype PubMed ID
nsv1078352 CNV deletion 25765185
nsv1160833 CNV duplication 26073780
nsv478091 CNV novel sequence insertion 20440878
nsv945887 CNV duplication 23825009

Variation tolerance for AKIRIN1 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKIRIN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKIRIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKIRIN1 Gene

Disorders for AKIRIN1 Gene

Relevant External Links for AKIRIN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKIRIN1

No disorders were found for AKIRIN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKIRIN1 Gene

Publications for AKIRIN1 Gene

  1. Evolution of the multifaceted eukaryotic akirin gene family. (PMID: 19200367) Macqueen D.J. … Johnston I.A. (BMC Evol. Biol. 2009) 2 3 64
  2. Akirins are highly conserved nuclear proteins required for NF-kappaB- dependent gene expression in Drosophila and mice. (PMID: 18066067) Goto A. … Reichhart J.-M. (Nat. Immunol. 2008) 3 4 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for AKIRIN1 Gene

Sources for AKIRIN1 Gene

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