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Aliases for AKIRIN1 Gene

Aliases for AKIRIN1 Gene

  • Akirin 1 2 3
  • C1orf108 3 4
  • Chromosome 1 Open Reading Frame 108 2
  • Akirin-1 3
  • STRF2 3

External Ids for AKIRIN1 Gene

Previous HGNC Symbols for AKIRIN1 Gene

  • C1orf108

Previous GeneCards Identifiers for AKIRIN1 Gene

  • GC01P039230
  • GC01P039456
  • GC01P037576

Summaries for AKIRIN1 Gene

GeneCards Summary for AKIRIN1 Gene

AKIRIN1 (Akirin 1) is a Protein Coding gene. An important paralog of this gene is AKIRIN2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKIRIN1 Gene

Genomics for AKIRIN1 Gene

Regulatory Elements for AKIRIN1 Gene

Genomic Location for AKIRIN1 Gene

38,991,223 bp from pter
39,006,065 bp from pter
14,843 bases
Plus strand

Genomic View for AKIRIN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKIRIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKIRIN1 Gene

Proteins for AKIRIN1 Gene

  • Protein details for AKIRIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DZU6
    • Q0VDB3
    • Q53FK8

    Protein attributes for AKIRIN1 Gene

    192 amino acids
    Molecular mass:
    21867 Da
    Quaternary structure:
    No Data Available
    • Akiraka ni suru means making things clear in Japanese. The name is given based on the presence of the clear nuclear localization signal
    • Sequence=AAI19747.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AKIRIN1 Gene


neXtProt entry for AKIRIN1 Gene

Proteomics data for AKIRIN1 Gene at MOPED

Post-translational modifications for AKIRIN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKIRIN1 Gene

No data available for DME Specific Peptides for AKIRIN1 Gene

Domains for AKIRIN1 Gene

Protein Domains for AKIRIN1 Gene


Suggested Antigen Peptide Sequences for AKIRIN1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H9L7
  • Belongs to the akirin family.
genes like me logo Genes that share domains with AKIRIN1: view

No data available for Gene Families for AKIRIN1 Gene

Function for AKIRIN1 Gene

Gene Ontology (GO) - Molecular Function for AKIRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with AKIRIN1: view

Phenotypes for AKIRIN1 Gene

MGI mutant phenotypes for AKIRIN1:
inferred from 2 alleles
GenomeRNAi human phenotypes for AKIRIN1:
genes like me logo Genes that share phenotypes with AKIRIN1: view

Animal Models for AKIRIN1 Gene

MGI Knock Outs for AKIRIN1:

Animal Model Products

CRISPR Products

miRNA for AKIRIN1 Gene

miRTarBase miRNAs that target AKIRIN1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKIRIN1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AKIRIN1 Gene

Localization for AKIRIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKIRIN1 Gene

Subcellular locations from

Jensen Localization Image for AKIRIN1 Gene COMPARTMENTS Subcellular localization image for AKIRIN1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for AKIRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18066067
GO:0005654 nucleoplasm IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with AKIRIN1: view

Pathways for AKIRIN1 Gene

SuperPathways for AKIRIN1 Gene

No Data Available

Interacting Proteins for AKIRIN1 Gene

Gene Ontology (GO) - Biological Process for AKIRIN1 Gene


No data available for Pathways by source for AKIRIN1 Gene

Transcripts for AKIRIN1 Gene

Unigene Clusters for AKIRIN1 Gene

Akirin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKIRIN1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKIRIN1 Gene

No ASD Table

Relevant External Links for AKIRIN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AKIRIN1 Gene

mRNA expression in normal human tissues for AKIRIN1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AKIRIN1 Gene

SOURCE GeneReport for Unigene cluster for AKIRIN1 Gene Hs.293563

mRNA Expression by UniProt/SwissProt for AKIRIN1 Gene

Tissue specificity: Widely expressed with the highest expression in heart, liver, placenta and peripheral blood leukocytes.
genes like me logo Genes that share expressions with AKIRIN1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AKIRIN1 Gene

Orthologs for AKIRIN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for AKIRIN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AKIRIN1 35
  • 99.83 (n)
  • 100 (a)
(Bos Taurus)
Mammalia AKIRIN1 35
  • 95.14 (n)
  • 95.31 (a)
  • 95 (a)
(Canis familiaris)
Mammalia AKIRIN1 35
  • 92.53 (n)
  • 93.23 (a)
  • 94 (a)
(Mus musculus)
Mammalia Akirin1 35
  • 88.13 (n)
  • 91.1 (a)
Akirin1 16
Akirin1 36
  • 93 (a)
(Monodelphis domestica)
Mammalia AKIRIN1 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia AKIRIN1 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Akirin1 35
  • 89.01 (n)
  • 91.62 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4204 35
tropical clawed frog
(Silurana tropicalis)
Amphibia akirin1 35
  • 74.2 (n)
  • 78.53 (a)
Str.16846 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1697 35
(Danio rerio)
Actinopterygii akirin1 35
  • 66.67 (n)
  • 73.89 (a)
akirin1 36
  • 59 (a)
wufa96c11 35
fruit fly
(Drosophila melanogaster)
Insecta akirin 36
  • 33 (a)
Species with no ortholog for AKIRIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKIRIN1 Gene

Gene Tree for AKIRIN1 (if available)
Gene Tree for AKIRIN1 (if available)

Paralogs for AKIRIN1 Gene

Paralogs for AKIRIN1 Gene

Selected SIMAP similar genes for AKIRIN1 Gene using alignment to 3 proteins: Pseudogenes for AKIRIN1 Gene

genes like me logo Genes that share paralogs with AKIRIN1: view

Variants for AKIRIN1 Gene

Sequence variations from dbSNP and Humsavar for AKIRIN1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs999917 -- 39,006,034(+) TTTAA(A/T)AATTA utr-variant-3-prime
rs999918 -- 39,006,382(+) CACCC(C/G)CCCCA downstream-variant-500B
rs1065566 -- 38,993,276(+) gggcg(A/G)ggtgg intron-variant
rs1555747 -- 38,994,324(+) GAAAG(C/G)TCCTG intron-variant
rs2013119 -- 39,000,506(-) GCTGG(A/G)CGTGG intron-variant

Relevant External Links for AKIRIN1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AKIRIN1 Gene

Disorders for AKIRIN1 Gene

No disorders were found for AKIRIN1 Gene.

No data available for UniProtKB/Swiss-Prot for AKIRIN1 Gene

Publications for AKIRIN1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Akirins are highly conserved nuclear proteins required for NF-kappaB- dependent gene expression in Drosophila and mice. (PMID: 18066067) Goto A. … Reichhart J.-M. (Nat. Immunol. 2008) 3 4
  5. Evolution of the multifaceted eukaryotic akirin gene family. (PMID: 19200367) Macqueen D.J. … Johnston I.A. (BMC Evol. Biol. 2009) 2 3

Products for AKIRIN1 Gene

Sources for AKIRIN1 Gene

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