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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AKIP1 Gene

protein-coding   GIFtS: 44
GCID: GC11P008932

A kinase (PRKA) interacting protein 1

(Previous name: chromosome 11 open reading frame 17 )
(Previous symbol: C11orf17)
 Explore 1 disease affiliated with
AKIP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AKIP1    

Aliases
for AKIP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
A Kinase (PRKA) Interacting Protein 11 2     Breast Cancer Associated Gene 32
BCA31 2 3 5     Koyt Binding Protein 12
C11orf171 2 3 5     Koyt Binding Protein 22
Proline-Rich Protein BCA32 3     Koyt Binding Protein 32
Chromosome 11 Open Reading Frame 171     Breast Cancer-Associated Gene 3 Protein3
A-Kinase-Interacting Protein 12     PKA-Interacting Protein3

External Ids:    HGNC: 11701   Entrez Gene: 566722   Ensembl: ENSG000001664527   OMIM: 6091915   UniProtKB: Q9NQ313   

Export aliases for AKIP1 gene to outside databases


Summaries
for AKIP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AKIP1:
This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of
the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced
transcript variants have been described for this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: AKIP1_HUMAN, Q9NQ31
Function: Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit
RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase
signaling pathway on the NF-kappa-B activation cascade




Genomic Views
for AKIP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for AKIP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AKIP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AKIP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.3

AKIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKIP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P008932:  view genomic region     (about GC identifiers)

Start:
 8,932,686 bp from pter      End:
 8,941,631 bp from pter
Size:
 8,946 bases      Orientation:
 plus strand

Proteins
for AKIP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AKIP1_HUMAN, Q9NQ31 (See protein sequence)
Recommended Name: A-kinase-interacting protein 1  
Size: 210 amino acids; 23114 Da
Subunit: Interacts with PRKACA and RELA
Subcellular location: Nucleus. Note=Locates to punctate spots
Secondary accessions: Q8NBS2 Q8TAC6 Q8TAD3 Q8TAE0
Alternative splicing: 3 isoforms:  Q9NQ31-1   Q9NQ31-2   Q9NQ31-3   

Explore the universe of human proteins at neXtProt for AKIP1: NX_Q9NQ31

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NQ31

    • AKIP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001193575.1  NP_001193576.1  NP_001193577.1  NP_065693.2  

    ENSEMBL proteins: 
     ENSP00000299576   ENSP00000310459   ENSP00000310644   ENSP00000434726   ENSP00000433510  
     ENSP00000434785   ENSP00000434820   ENSP00000436989   ENSP00000379885   ENSP00000431331  
     ENSP00000431602  

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    Uscn Proteins for AKIP1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    AKIP1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for AKIP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9NQ31


    Function
    for AKIP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AKIP1_HUMAN, Q9NQ31
    Function: Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit
    RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase
    signaling pathway on the NF-kappa-B activation cascade

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKIP1
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    hsa-miR-505 hsa-miR-4311 hsa-miR-34c-5p hsa-miR-449b hsa-miR-1324 hsa-miR-216b hsa-miR-449a hsa-miR-3159
    SwitchGear 3'UTR luciferase reporter plasmid: AKIP1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15630084


    AKIP1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for AKIP1:
     Increased S DNA content  Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for AKIP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AKIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for AKIP1 (Q9NQ311, 3 ENSP000003104594) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKACAP176121, 3, ENSP000003095914EBI-517035,EBI-476586 I2D: score=2 STRING: ENSP00000309591
    SIRT1Q96EB63, ENSP000002120154I2D: score=1 STRING: ENSP00000212015
    SENP8Q96LD83, ENSP000003405054I2D: score=1 STRING: ENSP00000340505
    NEDD8Q158433, ENSP000002504954I2D: score=1 STRING: ENSP00000250495
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034446substrate adhesion-dependent cell spreading IEA--


    AKIP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AKIP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AKIP1
    Search CenterWatch for drugs/clinical trials and news about AKIP1 

    Transcripts
    for AKIP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AKIP1 gene (6 alternative transcripts): 
    NM_001206646.1  NM_001206647.1  NM_001206648.1  NM_020642.3  NM_001206645.1  NM_182901.3  

    Unigene Cluster for AKIP1:

    A kinase (PRKA) interacting protein 1
    Hs.131180  [show with all ESTs]
    Unigene Representative Sequence: AK075308
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299576(uc001mgy.3 uc021qdi.1) ENST00000309377(uc001mgx.3 uc001mha.3)
    ENST00000309357(uc001mgz.3 uc021qdh.1) ENST00000529876(uc010rbr.2 uc010rbs.2)
    ENST00000525005 ENST00000524577 ENST00000534506 ENST00000530281 ENST00000396648
    ENST00000534147 ENST00000529942

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    hsa-miR-505 hsa-miR-4311 hsa-miR-34c-5p hsa-miR-449b hsa-miR-1324 hsa-miR-216b hsa-miR-449a hsa-miR-3159
    SwitchGear 3'UTR luciferase reporter plasmid: AKIP1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF493783.1 AF493784.1 AF493785.1 AF512007.1 AK075308.1 AK294506.1 AK294549.1 BC030996.2 
    NR_045417.1 NR_045418.1 

    14 DOTS entries:

    DT.95173005  DT.100036131  DT.99927411  DT.95288494  DT.100814943  DT.405560  DT.99948067  DT.92422103 
    DT.102836091  DT.40128672  DT.40130914  DT.91853396  DT.92025857  DT.95158344 

    24/71 AceView cDNA sequences (see all 71):

    CA430307 AF493785 AF493783 BI160019 AI769232 AF493784 BM449949 BU734702 
    AI933861 BM763534 NM_020642 BP346582 AI360308 BP355293 AI472290 AW340643 
    BI256804 AI418249 BM759108 BX099185 CB148674 AI470978 AI692778 AA843864 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for AKIP1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d
    SP1:              -     -                                   -                           
    SP2:              -     -                 -                 -                           
    SP3:                                                                                    
    SP4:                                      -                 -                           
    SP5:                                      -           -     -                           


    ECgene alternative splicing isoforms for AKIP1

    Expression
    for AKIP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AKIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AKIP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See AKIP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AKIP1

    SOURCE GeneReport for Unigene cluster: Hs.131180

    UniProtKB/Swiss-Prot: AKIP1_HUMAN, Q9NQ31
    Tissue specificity: Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal
    muscle. Up-regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain

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    In Situ
    Assay Products:     
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    Orthologs
    for AKIP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for AKIP1 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Akip11 , 5 RIKEN cDNA D930014E17 gene5
    A kinase (PRKA) interacting protein 11    		 78.95(n)1
    72.73(a)1    		   7 (57.44 cM)5
    573731  NM_020616.11  NP_065641.11 
     1097036905 
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkey-8l13.16
    		 si:dkey-8l13.1
    		 34(a)
    		 1 ↔ 1
    		 18(16609892-16613146)


    ENSEMBL Gene Tree for AKIP1 (if available)
    TreeFam Gene Tree for AKIP1 (if available) 

    Paralogs
    for AKIP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AKIP1 gene

    AKIP1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for AKIP1
    PGOHUM00000243292


    Genomic Variants
    for AKIP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/149 NCBI SNPs in AKIP1 are shown (see all 149)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs756525731,2
    		--8608205(+) AGTTAC/TGGGCC 6 -- int11Minor allele frequency- T:0.01NA 120
    rs745433491,2
    		F,--8608350(+) CCCTAC/TTTGTA 6 -- int11Minor allele frequency- T:0.03NA 120
    rs776412441,2
    		F,--8608479(+) GAGAGT/CGGGCA 6 -- int11Minor allele frequency- C:0.03NA 120
    rs740533101,2
    		C,F,--8608592(+) CCTTTT/CCTGGC 6 -- int13Minor allele frequency- C:0.06WA CSA 122
    rs27425151,2
    		F,--8609330(-) TCTCAA/GCTTAA 6 -- int11Minor allele frequency- G:0.03WA 118
    rs79507771,2
    		C,F,A,--8609364(+) NNNNAG/AATTTT 6 -- int12Minor allele frequency- A:0.07WA NA 238
    rs79392681,2
    		C,F,--8609447(+) AACTCA/TTAGTT 6 -- int11Minor allele frequency- T:0.12WA 118
    rs124209471,2
    		H--8609776(+) GAATTC/TTGAGG 6 -- int10--------
    rs795915401,2
    		F,--8610136(+) TCATAC/TACATT 6 -- int11Minor allele frequency- T:0.03NA 120
    rs798202531,2
    		F,--8610431(+) TCTGGC/TCCTTA 6 -- int11Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for AKIP1 (8932686 - 8941631 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for AKIP1: --

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKIP1
    DNA2.0 Custom Variant and Variant Library Synthesis for AKIP1

    Disorders / Diseases
    for AKIP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AKIP1 for disorders           About GeneDecksing

    OMIM gene information: 609191    OMIM disorders: --

    1 disease for AKIP1:    About MalaCards
    breast cancer


    Export disorders for AKIP1 gene to outside databases

    Publications
    for AKIP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AKIP1 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with AKIP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A-kinase-interacting protein 1 (AKIP1) acts as a mole cular determinant of PKA in NF-kappaB signaling. (PubMed id 20562110)1, 2, 3 Gao N....Okamoto T. (2010)
    2. AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65. (PubMed id 18178962)1, 2, 3 Gao N....Okamoto T. (2008)
    3. A-kinase-interacting protein localizes protein kinase A in the nucleus. (PubMed id 15630084)1, 2, 3 Sastri M.... Taylor S.S. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Characterization of a novel human breast cancer associated gene (BCA3) encoding an alternatively spliced proline-rich protein. (PubMed id 12527432)1, 2 Kitching R.... Seth A. (2003)
    7. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PubMed id 11528127)1, 2 Amid C.... Schmidt E.R. (2001)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    External Searches for AKIP1 gene

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    Genome Databases showing AKIP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56672 HGNC: 1170 AceView: C11orf17 Ensembl:ENSG00000166452 euGenes: HUgn56672
    ECgene: AKIP1 H-InvDB: AKIP1

    Other Databases showing AKIP1 gene

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    Specialized Databases showing AKIP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for AKIP1 Pharmacogenomics, SNPs, Pathways

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