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Aliases for AKIP1 Gene

Aliases for AKIP1 Gene

  • A-Kinase Interacting Protein 1 2 3 5
  • A Kinase (PRKA) Interacting Protein 1 2 3
  • Proline-Rich Protein BCA3 3 4
  • C11orf17 3 4
  • BCA3 3 4
  • Breast Cancer-Associated Gene 3 Protein 4
  • Chromosome 11 Open Reading Frame 17 2
  • Breast Cancer Associated Gene 3 3
  • PKA-Interacting Protein 4
  • Koyt Binding Protein 1 3
  • Koyt Binding Protein 2 3
  • Koyt Binding Protein 3 3

External Ids for AKIP1 Gene

Previous HGNC Symbols for AKIP1 Gene

  • C11orf17

Summaries for AKIP1 Gene

Entrez Gene Summary for AKIP1 Gene

  • This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for AKIP1 Gene

AKIP1 (A-Kinase Interacting Protein 1) is a Protein Coding gene. Diseases associated with AKIP1 include Breast Cancer.

UniProtKB/Swiss-Prot for AKIP1 Gene

  • Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKIP1 Gene

Genomics for AKIP1 Gene

Regulatory Elements for AKIP1 Gene

Enhancers for AKIP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AKIP1 on UCSC Golden Path with GeneCards custom track

Promoters for AKIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AKIP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AKIP1 Gene

Chromosome:
11
Start:
8,911,118 bp from pter
End:
8,920,084 bp from pter
Size:
8,967 bases
Orientation:
Plus strand

Genomic View for AKIP1 Gene

Genes around AKIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKIP1 Gene

Proteins for AKIP1 Gene

  • Protein details for AKIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ31-AKIP1_HUMAN
    Recommended name:
    A-kinase-interacting protein 1
    Protein Accession:
    Q9NQ31
    Secondary Accessions:
    • Q8NBS2
    • Q8TAC6
    • Q8TAD3
    • Q8TAE0

    Protein attributes for AKIP1 Gene

    Size:
    210 amino acids
    Molecular mass:
    23114 Da
    Quaternary structure:
    • Interacts with PRKACA and RELA.

    Alternative splice isoforms for AKIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKIP1 Gene

Proteomics data for AKIP1 Gene at MOPED

Post-translational modifications for AKIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AKIP1 Gene

Domains & Families for AKIP1 Gene

Protein Domains for AKIP1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for AKIP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AKIP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for AKIP1 Gene

Function for AKIP1 Gene

Molecular function for AKIP1 Gene

UniProtKB/Swiss-Prot Function:
Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.
genes like me logo Genes that share phenotypes with AKIP1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKIP1 Gene

Localization for AKIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKIP1 Gene

Nucleus. Note=Locates to punctate spots.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKIP1 Gene COMPARTMENTS Subcellular localization image for AKIP1 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for AKIP1 Gene

Pathways & Interactions for AKIP1 Gene

SuperPathways for AKIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AKIP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AKIP1 Gene

Drugs & Compounds for AKIP1 Gene

No Compound Related Data Available

Transcripts for AKIP1 Gene

Unigene Clusters for AKIP1 Gene

A kinase (PRKA) interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKIP1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: - - - -
SP3:
SP4: - -
SP5: - - -
SP6: -

Relevant External Links for AKIP1 Gene

GeneLoc Exon Structure for
AKIP1
ECgene alternative splicing isoforms for
AKIP1

Expression for AKIP1 Gene

mRNA expression in normal human tissues for AKIP1 Gene

Protein differential expression in normal tissues from HIPED for AKIP1 Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AKIP1 Gene



SOURCE GeneReport for Unigene cluster for AKIP1 Gene Hs.131180

mRNA Expression by UniProt/SwissProt for AKIP1 Gene

Q9NQ31-AKIP1_HUMAN
Tissue specificity: Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up-regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain.
genes like me logo Genes that share expression patterns with AKIP1: view

Protein tissue co-expression partners for AKIP1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AKIP1 Gene

Orthologs for AKIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKIP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AKIP1 35
  • 85.43 (n)
  • 79.23 (a)
AKIP1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKIP1 35
  • 83.67 (n)
  • 76 (a)
AKIP1 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akip1 35
  • 78.95 (n)
  • 72.73 (a)
Akip1 16
Akip1 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AKIP1 35
  • 99.37 (n)
  • 100 (a)
AKIP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akip1 35
  • 78.95 (n)
  • 74.16 (a)
oppossum
(Monodelphis domestica)
Mammalia AKIP1 36
  • 30 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKIP1 36
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii AKIP1 36
  • 35 (a)
OneToOne
Species with no ortholog for AKIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKIP1 Gene

ENSEMBL:
Gene Tree for AKIP1 (if available)
TreeFam:
Gene Tree for AKIP1 (if available)

Paralogs for AKIP1 Gene

Pseudogenes.org Pseudogenes for AKIP1 Gene

genes like me logo Genes that share paralogs with AKIP1: view

No data available for Paralogs for AKIP1 Gene

Variants for AKIP1 Gene

Sequence variations from dbSNP and Humsavar for AKIP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_021565 -
rs35131475 - 8,914,917(-) TCCCT(A/G)TGTCC nc-transcript-variant, reference, missense
rs909464 -- 8,918,078(-) AGAGG(C/T)GTCTA intron-variant, utr-variant-3-prime
rs1560569 -- 8,918,340(-) TTTCA(C/T)GCCTG intron-variant, utr-variant-3-prime
rs1883097 -- 8,917,272(-) CAAGT(A/G)GAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKIP1 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
essv24306 CNV CNV 17122850
nsv435923 CNV Deletion 17901297
nsv832062 CNV Loss 17160897

Variation tolerance for AKIP1 Gene

Residual Variation Intolerance Score: 72.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.87; 74.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AKIP1 Gene

Disorders for AKIP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AKIP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search AKIP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AKIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKIP1
genes like me logo Genes that share disorders with AKIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AKIP1 Gene

Publications for AKIP1 Gene

  1. A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signaling. (PMID: 20562110) Gao N. … Okamoto T. (J. Biol. Chem. 2010) 2 3 4 67
  2. AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65. (PMID: 18178962) Gao N. … Okamoto T. (J. Biol. Chem. 2008) 2 3
  3. A-kinase-interacting protein localizes protein kinase A in the nucleus. (PMID: 15630084) Sastri M. … Taylor S.S. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for AKIP1 Gene

Sources for AKIP1 Gene

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