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Aliases for AKIP1 Gene

Aliases for AKIP1 Gene

  • A Kinase (PRKA) Interacting Protein 1 2 3
  • C11orf17 3 4 6
  • BCA3 3 4 6
  • Proline-Rich Protein BCA3 3 4
  • Breast Cancer-Associated Gene 3 Protein 4
  • Chromosome 11 Open Reading Frame 17 2
  • Breast Cancer Associated Gene 3 3
  • A-Kinase-Interacting Protein 1 3
  • PKA-Interacting Protein 4
  • Koyt Binding Protein 1 3
  • Koyt Binding Protein 2 3
  • Koyt Binding Protein 3 3

External Ids for AKIP1 Gene

Previous HGNC Symbols for AKIP1 Gene

  • C11orf17

Summaries for AKIP1 Gene

Entrez Gene Summary for AKIP1 Gene

  • This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for AKIP1 Gene

AKIP1 (A Kinase (PRKA) Interacting Protein 1) is a Protein Coding gene. Diseases associated with AKIP1 include breast cancer.

UniProtKB/Swiss-Prot for AKIP1 Gene

  • Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKIP1 Gene

Genomics for AKIP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AKIP1 Gene

Start:
8,911,139 bp from pter
End:
8,920,084 bp from pter
Size:
8,946 bases
Orientation:
Plus strand

Genomic View for AKIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKIP1 Gene

No data available for Regulatory Elements for AKIP1 Gene

Proteins for AKIP1 Gene

  • Protein details for AKIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ31-AKIP1_HUMAN
    Recommended name:
    A-kinase-interacting protein 1
    Protein Accession:
    Q9NQ31
    Secondary Accessions:
    • Q8NBS2
    • Q8TAC6
    • Q8TAD3
    • Q8TAE0

    Protein attributes for AKIP1 Gene

    Size:
    210 amino acids
    Molecular mass:
    23114 Da
    Quaternary structure:
    • Interacts with PRKACA and RELA.

    Alternative splice isoforms for AKIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKIP1 Gene

Proteomics data for AKIP1 Gene at MOPED

Post-translational modifications for AKIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AKIP1 Gene

Domains for AKIP1 Gene

Protein Domains for AKIP1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for AKIP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AKIP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for AKIP1 Gene

Function for AKIP1 Gene

Molecular function for AKIP1 Gene

UniProtKB/Swiss-Prot Function: Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.

Gene Ontology (GO) - Molecular Function for AKIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15630084
genes like me logo Genes that share ontologies with AKIP1: view

Phenotypes for AKIP1 Gene

GenomeRNAi human phenotypes for AKIP1:
genes like me logo Genes that share phenotypes with AKIP1: view

Animal Model Products

CRISPR Products

miRNA for AKIP1 Gene

miRTarBase miRNAs that target AKIP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AKIP1 Gene

Localization for AKIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKIP1 Gene

Nucleus. Note=Locates to punctate spots.

Gene Ontology (GO) - Cellular Components for AKIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with AKIP1: view

No data available for Subcellular locations from COMPARTMENTS for AKIP1 Gene

Pathways for AKIP1 Gene

SuperPathways for AKIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AKIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034446 substrate adhesion-dependent cell spreading IEA --
genes like me logo Genes that share ontologies with AKIP1: view

No data available for Pathways by source for AKIP1 Gene

Transcripts for AKIP1 Gene

Unigene Clusters for AKIP1 Gene

A kinase (PRKA) interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKIP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKIP1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: - - - -
SP3:
SP4: - -
SP5: - - -
SP6: -

Relevant External Links for AKIP1 Gene

GeneLoc Exon Structure for
AKIP1
ECgene alternative splicing isoforms for
AKIP1

Expression for AKIP1 Gene

mRNA expression in normal human tissues for AKIP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKIP1 Gene

SOURCE GeneReport for Unigene cluster for AKIP1 Gene Hs.131180

mRNA Expression by UniProt/SwissProt for AKIP1 Gene

Q9NQ31-AKIP1_HUMAN
Tissue specificity: Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up-regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain.
genes like me logo Genes that share expressions with AKIP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AKIP1 Gene

Orthologs for AKIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKIP1 35
  • 99.37 (n)
  • 100 (a)
AKIP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AKIP1 35
  • 85.43 (n)
  • 79.23 (a)
AKIP1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKIP1 35
  • 83.67 (n)
  • 76 (a)
AKIP1 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akip1 35
  • 78.95 (n)
  • 72.73 (a)
Akip1 16
Akip1 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AKIP1 36
  • 30 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKIP1 36
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akip1 35
  • 78.95 (n)
  • 74.16 (a)
zebrafish
(Danio rerio)
Actinopterygii AKIP1 36
  • 35 (a)
OneToOne
Species with no ortholog for AKIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKIP1 Gene

ENSEMBL:
Gene Tree for AKIP1 (if available)
TreeFam:
Gene Tree for AKIP1 (if available)

Paralogs for AKIP1 Gene

Pseudogenes.org Pseudogenes for AKIP1 Gene

genes like me logo Genes that share paralogs with AKIP1: view

No data available for Paralogs for AKIP1 Gene

Variants for AKIP1 Gene

Sequence variations from dbSNP and Humsavar for AKIP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs909464 -- 8,918,078(-) AGAGG(C/T)GTCTA intron-variant, utr-variant-3-prime
rs1560569 -- 8,918,340(-) TTTCA(C/T)GCCTG intron-variant, utr-variant-3-prime
rs1883097 -- 8,917,272(-) CAAGT(A/G)GAACA intron-variant
rs2016844 -- 8,917,387(-) AGTGC(A/G)TAAGC intron-variant, reference, missense
rs2016942 -- 8,917,240(-) ACTTT(C/T)GGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKIP1 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
essv24306 CNV CNV 17122850
nsv435923 CNV Deletion 17901297
nsv832062 CNV Loss 17160897

Relevant External Links for AKIP1 Gene

HapMap Linkage Disequilibrium report
AKIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKIP1 Gene

Disorders for AKIP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for AKIP1 Gene including...

Search for AKIP1 Gene in MalaCards »
genes like me logo Genes that share disorders with AKIP1: view

No data available for UniProtKB/Swiss-Prot for AKIP1 Gene

Publications for AKIP1 Gene

  1. A-kinase-interacting protein localizes protein kinase A in the nucleus. (PMID: 15630084) Sastri M. … Taylor S.S. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4
  2. AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65. (PMID: 18178962) Gao N. … Okamoto T. (J. Biol. Chem. 2008) 2 3 4
  3. A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signaling. (PMID: 20562110) Gao N. … Okamoto T. (J. Biol. Chem. 2010) 2 3 4
  4. Characterization of a novel human breast cancer associated gene (BCA3) encoding an alternatively spliced proline-rich protein. (PMID: 12527432) Kitching R. … Seth A. (Biochim. Biophys. Acta 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for AKIP1 Gene

Sources for AKIP1 Gene

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