AKD1 Gene
protein-coding GIFtS : 47
GCID: GC06 M109814
adenylate kinase domain containing 1 (Previous names: chromosome 6 open reading frame 224, adenylate kinase domain... ) (Previous symbols: C6orf224, AKD2, C6orf199 )
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Aliasesfor AKD1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Adenylate Kinase Domain Containing 1 1 2 FLJ421771 AKD21 2 3 MGC269541 C6orf1991 2 3 Chromosome 6 Open Reading Frame 1991 C6orf2241 2 3 Chromosome 6 Open Reading Frame 2241 Adenylate Kinase Domain Containing 21 2 RP1-70A9.12 DJ70A9.11 Adenylate Kinase Domain-Containing Protein 12 FLJ257911 Adenylate Kinase Domain-Containing Protein 23
Export aliases for AKD1 gene to outside databases Previous GC identifers: GC06M110060 GC06M107380
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Summariesfor AKD1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor AKD1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_025741.15 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for AKD1 Other transcription factors Search SABiosciences Chromatin IP Primers for AKD1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat AKD1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21 AKD1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06M109814: view genomic region
(about GC identifiers )
Start:
109,814,059 bp from pter
End:
110,012,420 bp from pter
Size:
198,362 bases
Orientation:
minus strand
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Proteinsfor AKD1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: AKD1_HUMAN, Q5TCS8 (See
protein sequence )Recommended Name: Adenylate kinase domain-containing protein 1 Size : 1911 amino acids; 221413 Da
Sequence caution : Sequence=AAI01715.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAI11949.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC05368.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions : A6NL75 B2RDJ0 B6ZDM7 Q3MIS4 Q5I0W8 Q6ZNF1 Q6ZVR7 Q8N7C6 Q8WW00 Q96NF4Alternative splicing : 6 isoforms : Q5TCS8-4 Q5TCS8-1 Q5TCS8-2 Q5TCS8-3 Q5TCS8-5, Q6ZNF1-1 Q5TCS8-6 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for AKD1: NX_Q5TCS8 Post-translational modifications:
Isoform 1 is phosphorylated on Ser-7241
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5TCS8 AKD1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001138600.2 NP_659462.1 ENSEMBL proteins: ENSP00000418771 ENSP00000419758 ENSP00000418670 ENSP00000347431 ENSP00000357944 ENSP00000285397 ENSP00000431394 ENSP00000407510 ENSP00000436325 ENSP00000410186 ENSP00000344637 Human Recombinant Protein Products: AKD1 Antibody Products: Assay Products for AKD1:
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Protein
Domains / Familiesfor AKD1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
AKD1 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q5TCS8 ProtoNet protein and cluster: Q5TCS8
1 Blocks protein family : IPB000850 Adenylate kinase UniProtKB/Swiss-Prot: AKD1_HUMAN, Q5TCS8 Similarity : Belongs to the adenylate kinase family
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Functionfor AKD1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AKD1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AKD1 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): AKD1 (NM_145025 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AKD1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AKD1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKD1
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005524 ATP binding
IEA -- GO:0017111 nucleoside-triphosphatase activity
IEA -- GO:0019205 nucleobase-containing compound kinase activity
IEA --
AKD1 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for AKD1 :
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Pathways & Interactionsfor AKD1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AKD1 3 Interacting proteins for AKD1 (Q5TCS8 2 , 3 ) via UniProtKB, MINT, STRING, and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006139 nucleobase-containing compound metabolic process
IEA --
AKD1 for ontologies About GeneDecksing
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Drugs & Compoundsfor AKD1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for AKD1 Search CenterWatch for drugs/clinical trials and news about AKD1
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Transcriptsfor AKD1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for AKD1 gene (4 alternative transcripts): NM_001145128.2 NM_145025.4 NM_001001706.2 NM_173559.1 Unigene Cluster for AKD1:
Adenylate kinase domain containing 1 Hs.205144 [show with all ESTs ] Unigene Representative Sequence: NM_001145128 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000470564 ENST00000490722 ENST00000491875 ENST00000355283 (uc011eat.1 )ENST00000466992 ENST00000368948 ENST00000285397 (uc003ptr.4 ) ENST00000524674 ENST00000448084 ENST00000532976 (uc003pts.2 ) ENST00000424296 (uc011eas.1 uc003ptn.2 )ENST00000341338 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AKD1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AKD1 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): AKD1 (NM_145025 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AKD1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AKD1
Additional cDNA sequence: AK055538.1 AK098657.1 AK124171.1 AK131244.1 AK315561.1 AL832162.1 BC022031.2 BC087860.1 BC101714.1 BC111948.1 BC143533.1
11 DOTS entries : DT.40127880 DT.451795
DT.40285647 DT.99933183 DT.100731436 DT.121363568 DT.75188990 DT.121363602 DT.40125645 DT.75188579 DT.97804040 24/28 AceView cDNA sequences (see all 28 ):
AK055538 BX097770 BM674969 AA508398 AA830897 AI733500 BG717830 BG719542 AA994767 BU959738 NM_145025 BM717470 BX348903 BC022031 BI596869 BM986886 AL832162 AI377361 AI792208 CD689554 AW129963 AK092103 R57653 AX747355 GeneLoc Exon Structure
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Expression for AKD1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section AKD1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image AKD1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Posterior foregut-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See AKD1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for AKD1 SOURCE GeneReport for Unigene cluster: Hs.205144 SABiosciences Custom PCR Arrays for AKD1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for AKD1Browse OriGene validated miRNA SYBR primer pairs Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat AKD1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat AKD1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat AKD1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKD1
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Orthologsfor AKD1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for AKD1 gene from 4/14 species (see all 14 ) About this table
ENSEMBL Gene Tree for AKD1 (if available)TreeFam Gene Tree for AKD1 (if available)
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Paralogsfor AKD1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor AKD1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for AKD1 (109814059 - 110012420 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for AKD1 2 CNVs : 0089 32832
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing AKD1
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Disorders
/ Diseasesfor AKD1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
AKD1 for disorders About GeneDecksing 2 diseases for AKD1 : About MalaCards hepatitis c hepatitis Human Genome Epidemiology (HuGE) Navigator: AKD1 (2 documents) Export disorders for AKD1 gene to outside databases
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Publicationsfor AKD1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for AKD1 gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with AKD1) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 1 , 2 Mungall A.J.... Beck S. (2003) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Generalist genes analysis of DNA markers associated w ith mathematical ability and disability reveals shared influence across ages an d abilities. (PubMed id 20602751) 1 Docherty S.J....Plomin R. (2010) Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461) 1 Bennett E.J....Harper J.W. (2010) Genetic variation in IL28B predicts hepatitis C treat ment-induced viral clearance. (PubMed id 19684573) 1 Ge D....Goldstein D.B. (2009) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 1 Stelzl U.... Wanker E.E. (2005) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for AKD1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing AKD1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing AKD1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing AKD1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for AKD1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for AKD1 gene: Search GeneIP for patents involving AKD1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor AKD1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for AKD1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for AKD1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for AKD1 OriGene Protein Over-expression Lysate for AKD1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for AKD1 OriGene 3'-UTR Clone for AKD1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AKD1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AKD1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for AKD1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for AKD1 OriGene Custom Protein Services for AKD1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AKD1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing AKD1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat AKD1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat AKD1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat AKD1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat AKD1
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AKD1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKD1
ThermoFisher Antibodies for AKD1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AKD1
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Aliases for AKD1
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Disorders / Diseases for AKD1
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Expression for AKD1
Function for AKD1
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