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AKAP9 Gene

protein-coding GIFtS: 60

GC07P091408

A kinase (PRKA) anchor protein (yotiao) 9
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AKAP350 ^¹, ², ³
AKAP450 ^¹, ², ³, ⁵
CG-NAP ^¹, ², ³
HYPERION ^¹, ²
KIAA0803 ^¹, ², ³
MU-RMS-40.16A ^¹, ²
PRKA9 ^¹, ², ³
YOTIAO ^¹, ², ⁵

Descriptions
A kinase (PRKA) anchor protein (yotiao) 9 ^²
A-kinase anchor protein 350 kDa ^³
A-kinase anchor protein 450 kDa ^³
A-kinase anchor protein 9 ^²
A-kinase anchor protein, 350kDa ^²
A-kinase anchoring protein 450 ^²
AKAP 120-like protein ^³
AKAP 350 ^³
AKAP 450 ^³
AKAP120-like protein ^²
AKAP9-BRAF fusion protein ^²
Centrosome- and Golgi-localized PKN-associated protein ^³
Protein hyperion ^³
Protein kinase A-anchoring protein 9 ^³
Protein yotiao ^³
centrosome- and golgi-localized protein ^²
hgAKAP 350 ^³
kinase N-associated protein ^²
protein kinase A anchoring protein 9 ^²

External Ids
HGNC: 379¹
Entrez Gene: 10142²
UniProtKB: Q99996³
Ensembl: ENSG00000127914⁷

Search outside databases for aliases for AKAP9 gene

Previous GC identifers: GC07P090105 GC07P091168 GC07P091182 GC07P091214

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AKAP9:

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the

common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the

holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family.

Alternate splicing of this gene results in at least two isoforms that localize to the centrosome

and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal

transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine

kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon

and phosphodiesterase 4D3. [provided by RefSeq]

UniProtKB/Swiss-Prot: AKAP9_HUMAN, Q99996

Function: Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that

assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be

required to maintain the integrity of the Golgi apparatus. Isoform 4/Yotiao is associated with the

N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as

well as in neuronal synapses, suggesting a role in the organization of postsynaptic

specializations

Gene Wiki entry for AKAP9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AKAP9 gene

Entrez Gene cytogenetic band: 7q21-q22 Ensembl cytogenetic band: 7q21.2 HGNC cytogenetic band: 7q21-q22

AKAP9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P091408: (about GC identifiers)

Start:	91,408,128 bp from pter
End:	91,577,925 bp from pter
Size:	169,798 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 90,900,319-91,069,227

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079595.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AKAP9_HUMAN, Q99996 (See protein sequence)

Recommended Name: A-kinase anchor protein 9

Size: 3911 amino acids; 453667 Da

Subunit: Interacts with the regulatory region of protein kinase N (PKN), protein phosphatase 2A

(PP2A), protein phosphatase 1 (PP1) and the immature non-phosphorylated form of PKC epsilon.

Interacts with CIP4 and FNBP1

Subcellular location: Cytoplasm. Centrosome. Golgi apparatus. Note=Cytoplasmic in parietal cells

Sequence caution: Sequence=AAB86384.1; Type=Frameshift; Positions=1637; Sequence=AAC60380.1;

Type=Erroneous gene model prediction;

Secondary accessions: A4D1F0 A4D1F2 A4D1F4 O14869 O43355 O94895 Q75N20 Q9UQH3 Q9UQQ4 Q9Y6B8 Q9Y6Y2

Alternative splicing: 6 isoforms: Q99996-1 Q99996-2 Q99996-3 Q99996-4 Q99996-5 Q99996-6

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_005742.4 NP_671695.1 NP_671700.1 NP_671714.1

ENSEMBL proteins:

ENSP00000265737 ENSP00000378042 ENSP00000351922 ENSP00000378066 ENSP00000378065 ENSP00000348573

ENSP00000350813

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AKAP9)
	Human Recombinant Proteins from Abnova (AKAP9)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0005813	centrosome	TAS	10202149
GO:0005856	cytoskeleton	TAS	9482789

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Antibodies for AKAP9:

	Invitrogen Antibodies for AKAP9
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AKAP9
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (AKAP9), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AKAP9)
	Novus Biologicals Antibodies for AKAP9

Assays for AKAP9:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q99996

ProtoNet protein and cluster: Q99996

UniProtKB/Swiss-Prot: AKAP9_HUMAN, Q99996

Domain: RII-binding site, predicted to form an amphipathic helix, could participate in

protein-protein interactions with a complementary surface on the R-subunit dimer

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AKAP9)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AKAP9)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_005751

Applied Biosystems Silencer® siRNAs for AKAP9

Sigma-Aldrich siRNA and siRNA Panels for AKAP9

Sigma-Aldrich shRNA for AKAP9

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_005751
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_005751
untagged cDNA clones in CMV expression vector (see all 4): NM_005751

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005751

UniProtKB/Swiss-Prot: AKAP9_HUMAN, Q99996

Function: Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that

assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be

required to maintain the integrity of the Golgi apparatus. Isoform 4/Yotiao is associated with the

N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as

well as in neuronal synapses, suggesting a role in the organization of postsynaptic

specializations

Genatlas biochemistry entry for AKAP9:

a kinase (PRKA regulatory subunit RIIA) anchor protein 9,abundantly expressed in skeletal muscle

and pancreas,also expressed in brain,located in the centrosome,interacting with a splice variant

of GRIN1

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	9482789

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for AKAP9 (Your Favorite Gene powered by Ingenuity)

Cardiac &beta
cAMP-mediated Signaling

GeneDecks AKAP9 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for AKAP9

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	10390370
GO:0007165	signal transduction	TAS	10390370
GO:0007268	synaptic transmission	TAS	9482789

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AKAP9
4 Novoseek chemical compound relationships for AKAP9 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	34.08	3	15528278 (2), 16647783 (1)
inositol 1,4,5 trisphosphate	31.32	1	15911880 (1)
cyclic amp	22.69	1	11799244 (1)
leucine	20.77	1	14982933 (1)

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1 PharmGKB drug compound relationship for AKAP9 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
antiarrhythmics	FA	11799244

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AKAP9)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AKAP9)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_005751

Sigma-Aldrich siRNA and siRNA Panels for AKAP9

Sigma-Aldrich shRNA for AKAP9

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005751 NM_147185

REFSEQ mRNAs for AKAP9 gene (4 alternative transcripts):

NM_005751.4 NM_147166.1 NM_147171.1 NM_147185.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005751 NM_147185

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_005751
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_005751
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_005751

Additional cDNA sequence:

AB018346.1 AB019691.1 AF026245.1 AF083037.1 AF091711.1 AF247727.2 AJ131693.1 AK000270.1

AK025160.1 AK026444.1 AK057546.1 AK074869.1 AL117418.1 AY528715.1 BC015533.2 BC027455.1

BC040932.1 BC062448.1

23 DOTS entries:

DT.452376 DT.100791885 DT.100656918 DT.100791886 DT.100791884 DT.91666841 DT.95287324 DT.431646

DT.91767641 DT.121112386 DT.40253873 DT.95337133 DT.121112521 DT.95113969 DT.97827477 DT.100027182

DT.213369 DT.100660446 DT.121112494 DT.75141107 DT.75196239 DT.75196327 DT.95287326

24/242 AceView cDNA sequences (see all 242 ):

AI887666 NM_147166 CA419148 W87644 BE464444 AA429253 AI253205 BE218438

BG290591 BC027455 Z38615 AA768003 CB134771 BX114750 BQ950320 AJ131693

T50165 CD251824 AL713507 BQ184576 AA931269 CA449636 BC040932 BQ186531

highest scoring ESTs for AKAP9:

AB019691 AA001872 AA429253 AA502941 AA677489 AA693583 AA702784 AA908642 AA931269 AA976494

Unigene Cluster for AKAP9:

A kinase (PRKA) anchor protein (yotiao) 9

Hs.651221 [show with all ESTs]

Unigene Representative Sequence: AJ131693

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for AKAP9 (see all 13 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^
SP1:													-																								-
SP2:													-																								-
SP3:																																					-
SP4:
SP5:													-

ExUns:	25a	·	25b	^	26a	·	26b	·	26c	^	27	^	28	^	29	^	30	^	31	^	32a	·	32b	^	33	^	34	^	35	^	36a	·	36b	^	37a	·	37b	·	37c	^	38a	·	38b	^	39	^	40a	·	40b	·	40c	^
SP1:							-		-																						-						-		-		-
SP2:									-																						-						-		-		-
SP3:									-																						-						-		-		-
SP4:																															-						-		-		-
SP5:

ExUns:	41	^	42	^	43a	·	43b	^	44	^	45	^	46	^	47a	·	47b	·	47c	^	48a	·	48b	·	48c	^	49a	·	49b
SP1:							-								-				-						-
SP2:							-								-				-						-
SP3:							-								-				-						-
SP4:							-								-				-
SP5:

About this scheme

ECgene alternative splicing isoforms for AKAP9

7 Ensembl transcripts including schematic representations:

ENST00000265737 ENST00000394534 ENST00000359028 ENST00000394565 ENST00000394564 ENST00000356239

ENST00000358100

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AKAP9 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AKAP9

¹ / ² / ³

8 probe-sets matching AKAP9 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36506_at²^{, 3}	U95-A	1	1.00	1.00	0.63	1.20	AB019691	1.00	1.00	1.00	1
67427_at²^{, 3}	U95-D	1	1.00	1.00	0.93	0.80	AA908642	0.80	1.00	0.91	1
215483_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK000270	0.60	1.00	0.82	1
210962_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB019691	1.00	1.00	1.00	1
207870_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005751	0.60	1.00	0.82	1
215483_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210962_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207870_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AKAP9 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTTGCCTAA

SOURCE GeneReport for Unigene cluster: Hs.651221
Expression variation in blood from EXPOLDB for AKAP9
UniProtKB/Swiss-Prot: AKAP9_HUMAN, Q99996
Tissue specificity: Widely expressed. Isoform 4/Yotiao is highly expressed in skeletal muscle and
in pancreas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AKAP9 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AKAP9¹	--	A kinase (PRKA) anchor protein (yotiao) 9	90.26(n) 87.73(a)	475224 XM_532456.2 XP_532456.2
chimpanzee (Pan troglodytes)	AKAP9¹	--	A kinase (PRKA) anchor protein (yotiao) 9	99.56(n) 99.39(a)	472440 XM_527814.2 XP_527814.2
cow (Bos taurus)	AKAP9¹	--	A kinase (PRKA) anchor protein (yotiao) 9	88.44(n) 86.08(a)	520784 XM_599034.3 XP_599034.3
rat (Rattus norvegicus)	Akap9¹	--	A kinase (PRKA) anchor protein (yotiao) 9	76.91(n) 72.26(a)	246150 XM_347223.3 XP_347224.3
mouse (Mus musculus)	Akap9^{1, 5}	5⁵	A kinase (PRKA) anchor protein (yotiao) 9^{1, 5}	76.89(n)¹ 71.28(a)¹	100986¹ NM_194462.2¹ NP_919444.2¹ AF343751⁵ AI527830⁵ (see all 28)

About this table Species with no ortholog for AKAP9

ENSEMBL Gene Tree for AKAP9

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AKAP9 gene

PCNT² TPR² EEA1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/787 NCBI SNPs in AKAP9 are shown (see all 787 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 185)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6964587^1,2	A,C,F,H	91468556(+)	`GAAATG/TAAAAC`	2	M/I	mis¹		12		EA NA EU WA	1054
	rs1859037^1,2	A,C,F,H	91406208(+)	`TCAGAG/ACACTA`	2	--	ng5¹		8		NA EA MN EU WA	851
	rs6960867^1,2	C,F,H	91550634(+)	`CAGCAA/GTCAGA`	2	N/S	mis¹		7		NA EU EA WA	650
--	rs2230768^1,2	C,F	91508072(+)	`TATGCA/C/GGCAAA`	4	R/Q R/P	mis¹ ese³		4		MN NA EA	283
	rs1063242^1,2	C,H	91552847(+)	`CAGAAT/CCTTGG`	2	S/P	mis¹ ese³		9		NA EA MN EU WA	925
--	rs35759833^1,2	C,F	91546834(-)	`AAGATT/CTGAAG`	2	R/K	mis¹		5		NA EU EA WA	472
	rs34327395^1,2	C,F	91567063(-)	`CTTCAT/CAACCA`	2	V/M	mis¹		5		NA EU EA WA	490
	rs34956633^1,2	C,F	91564540(-)	`GCTTCT/CGGAAT`	2	R/Q	mis¹		5		NA EU EA WA	492
	rs4727266^1,2	A	91408065(+)	`GCCCAC/TGAGGC`	2	--	ng5¹ tfbs³		0	--	--	--	--
--	rs4727267^1,2	A	91408226(+)	`GGAGCC/GCCGGA`	2	--	ut5¹ ese³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for AKAP9 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604001 disorders: 611820

UniProtKB/Swiss-Prot: AKAP9_HUMAN, Q99996

Defects in AKAP9 are the cause of long QT syndrome type 11 (LQT11) [MIM:611820]. Long QT

syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic

ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional

stress. They can present with a sentinel event of sudden cardiac death in infancy

1 Novoseek disease relationship for AKAP9 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
thyroid papillary carcinoma	56.55	2	16753739 (2)

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1 PharmGKB disease relationship for AKAP9 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Long QT Syndrome	FA	11799244

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Human Gene Mutation Database: AKAP9
Human Genome Epidemiology Navigator: AKAP9 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/52 PubMed articles for AKAP9 gene (see all 52 ):

Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. (PubMed id 11799244)^{1, 3, 7} Marx S.O....Kass R.S. (2002)
Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1. (PubMed id 9482789)^{2, 3, 4} Lin J.W.... Sheng M. (1998)
AKAP350, a multiply spliced protein kinase A-anchoring protein associated with centrosomes. (PubMed id 9915845)^{1, 3, 4} Schmidt P.H.... Goldenring J.R. (1999)
Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the Golgi apparatus. (PubMed id 10358086)^{1, 3, 4} Takahashi M.... Ono Y. (1999)
Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450. (PubMed id 10202149)^{1, 3, 4} Witczak O.... Oerstavik S. (1999)
Mutation of an A-kinase-anchoring protein causes long-QT syndrome. (PubMed id 18093912)^{1, 3, 4} Chen L....Kass R.S. (2007)
AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus. (PubMed id 15047863)^{3, 4} Larocca M.C....Goldenring J.R. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{3, 4} Scherer S.W....Tsui L.C. (2003)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{3, 4} Hillier L.W.... Wilson R.K. (2003)
Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. (PubMed id 10390370)^{2, 3} Westphal R.S....Scott J.D. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10142	HGNC: 379	AceView: AKAP9	Ensembl:ENSG00000127914	euGenes: HUgn10142
ECgene: AKAP9	H-InvDB: AKAP9

(According to HUGE)
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HUGE: KIAA0803

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for AKAP9	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for AKAP9
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AKAP9:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AKAP9-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AKAP9		Antibodies for AKAP9
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AKAP9		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (AKAP9)
	Antibodies (AKAP9)
	Chimera RNAi (AKAP9)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (AKAP9)
	Antibodies (AKAP9)

Search OriGene for AKAP9

Search Tocris compounds for AKAP9

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for AKAP9

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
AKAP9 Gene at Home site.
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AKAP9 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for AKAP9

Summaries
for AKAP9

Genomic Location
for AKAP9

Proteins
for AKAP9

Protein Domains/
Families
for AKAP9

Gene Function
for AKAP9

Pathways & Interactions
for AKAP9

Drugs & Compounds
for AKAP9

Transcripts
for AKAP9

Expression
for AKAP9

Orthologs
for AKAP9

Paralogs
for AKAP9

SNPs/Variants
for AKAP9

Disorders & Mutations
for AKAP9

Medical News
for AKAP9

Publications
for AKAP9

Search for AKAP9

Genome Databases showing AKAP9

Other Databases showing AKAP9

Specialized Databases showing AKAP9

Licensable Technologies
for AKAP9

Services
for AKAP9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AKAP9 (Gene Symbol)
AKAP350
AKAP450
CG-NAP
HYPERION
KIAA0803
MU-RMS-40.16A
PRKA9
YOTIAO
A kinase (PRKA) anchor protein (yotiao) 9
A-kinase anchor protein 350 kDa
A-kinase anchor protein 450 kDa
A-kinase anchor protein 9
A-kinase anchor protein, 350kDa
A-kinase anchoring protein 450
AKAP 120-like protein
AKAP 350
AKAP 450
AKAP120-like protein
AKAP9-BRAF fusion protein
Centrosome- and Golgi-localized PKN-associated protein
Protein hyperion
Protein kinase A-anchoring protein 9
Protein yotiao
centrosome- and golgi-localized protein
hgAKAP 350
kinase N-associated protein
protein kinase A anchoring protein 9

AKAP9 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor AKAP9

Summariesfor AKAP9

Genomic Locationfor AKAP9

Proteinsfor AKAP9

Protein Domains/Familiesfor AKAP9

Gene Functionfor AKAP9

Pathways & Interactionsfor AKAP9

Drugs & Compoundsfor AKAP9

Transcriptsfor AKAP9

Expression for AKAP9

Orthologsfor AKAP9

Paralogsfor AKAP9

SNPs/Variantsfor AKAP9

Disorders & Mutationsfor AKAP9

Medical Newsfor AKAP9

Publicationsfor AKAP9

Search for AKAP9

Genome Databases showing AKAP9

Other Databases showing AKAP9

Specialized Databases showing AKAP9

Licensable Technologiesfor AKAP9

Servicesfor AKAP9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AKAP9

Summaries
for AKAP9

Genomic Location
for AKAP9

Proteins
for AKAP9

Protein Domains/
Families
for AKAP9

Gene Function
for AKAP9

Pathways & Interactions
for AKAP9

Drugs & Compounds
for AKAP9

Transcripts
for AKAP9

Expression
for AKAP9

Orthologs
for AKAP9

Paralogs
for AKAP9

SNPs/Variants
for AKAP9

Disorders & Mutations
for AKAP9

Medical News
for AKAP9

Publications
for AKAP9

Licensable Technologies
for AKAP9

Services
for AKAP9