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AKAP8L Gene(Protein Coding)

A-Kinase Anchoring Protein 8 Like

GCID:
GC19M015380
GIFtS:
54
Genes Participants
UDN Logo

Aliases for AKAP8L Gene

Aliases for AKAP8L Gene

  • A-Kinase Anchoring Protein 8 Like 2 3 5
  • A Kinase (PRKA) Anchor Protein 8-Like 2 3
  • Homologous To AKAP95 Protein 3 4
  • Neighbor Of AKAP95 3 4
  • AKAP8-Like Protein 3 4
  • NAKAP95 3 4
  • HAP95 3 4
  • NAKAP 3 4
  • HA95 3 4
  • Testis Tissue Sperm-Binding Protein Li 90mP 3
  • Neighbor Of A Kinase Anchoring Protein 95 2
  • Neighbor Of A-Kinase Anchoring Protein 95 3
  • Neighbor Of A-Kinase-Anchoring Protein 95 4
  • Helicase A-Binding Protein 95 KDa 3
  • Helicase A-Binding Protein 95 4

External Ids for AKAP8L Gene

Previous GeneCards Identifiers for AKAP8L Gene

  • GC19M015352
  • GC19M015353
  • GC19M015490
  • GC19M015058

Summaries for AKAP8L Gene

GeneCards Summary for AKAP8L Gene

AKAP8L (A-Kinase Anchoring Protein 8 Like) is a Protein Coding gene. Diseases associated with AKAP8L include Hiv-1. Among its related pathways are Epstein-Barr virus infection. GO annotations related to this gene include poly(A) RNA binding and DEAD/H-box RNA helicase binding. An important paralog of this gene is ZNF326.

UniProtKB/Swiss-Prot for AKAP8L Gene

  • Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at Ser-10 of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903).

  • (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters (PubMed:11884601). Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses (PubMed:11402034). In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity (PubMed:25034436).

Gene Wiki entry for AKAP8L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP8L Gene

Genomics for AKAP8L Gene

Products:

  1. Regulatory Element

Regulatory Elements for AKAP8L Gene

Enhancers for AKAP8L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AKAP8L on UCSC Golden Path with GeneCards custom track

Promoters for AKAP8L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AKAP8L on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the AKAP8L gene promoter:

Genomic Location for AKAP8L Gene

Chromosome:
19
Start:
15,380,048 bp from pter
End:
15,419,141 bp from pter
Size:
39,094 bases
Orientation:
Minus strand

Genomic View for AKAP8L Gene

Genes around AKAP8L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAP8L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAP8L Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for AKAP8L Gene

Proteins for AKAP8L Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for AKAP8L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULX6-AKP8L_HUMAN
    Recommended name:
    A-kinase anchor protein 8-like
    Protein Accession:
    Q9ULX6
    Secondary Accessions:
    • B4DJ74
    • B5BU90
    • O94792
    • Q96J58
    • Q9NRQ0
    • Q9UGM0

    Protein attributes for AKAP8L Gene

    Size:
    646 amino acids
    Molecular mass:
    71649 Da
    Quaternary structure:
    • Interacts with DHX9, TMPO isoform Beta, PRPF40A, RNF43, lamin-B (PubMed:10748171, PubMed:11034899, PubMed:12538639 PubMed:16391387, PubMed:18313049). Interacts with HDAC3; increased during mitosis (PubMed:16980585). Interacts with EBV EBNA-LP (PubMed:11160753). Interacts with HIV-1 reverse transcriptase/ribonuclease H (PubMed:25034436).
    SequenceCaution:
    • Sequence=AAF86048.1; Type=Frameshift; Positions=553; Evidence={ECO:0000305}; Sequence=BAA34791.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for AKAP8L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKAP8L Gene

Proteomics data for AKAP8L Gene at MOPED

Protein Expression for AKAP8L Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for AKAP8L Gene

  • Phosphorylated on serine or threonine residues possibly by PKA; probably modulating the interaction with TMPO isoform Beta.
  • Ubiquitination at Lys 257, Lys 264, and Lys 533
  • Modification sites at PhosphoSitePlus

Other Protein References for AKAP8L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AKAP8L Gene

Domains & Families for AKAP8L Gene

Protein Domains for AKAP8L Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for AKAP8L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULX6

UniProtKB/Swiss-Prot:

AKP8L_HUMAN :
  • Belongs to the AKAP95 family.
  • Contains 2 C2H2 AKAP95-type zinc fingers.
Family:
  • Belongs to the AKAP95 family.
Similarity:
  • Contains 2 C2H2 AKAP95-type zinc fingers.
genes like me logo Genes that share domains with AKAP8L: view

No data available for Gene Families for AKAP8L Gene

Function for AKAP8L Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for AKAP8L Gene

UniProtKB/Swiss-Prot Function:
Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at Ser-10 of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters (PubMed:11884601). Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses (PubMed:11402034). In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity (PubMed:25034436).

Gene Ontology (GO) - Molecular Function for AKAP8L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18313049
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with AKAP8L: view

Phenotypes for AKAP8L Gene

GenomeRNAi human phenotypes for AKAP8L:
genes like me logo Genes that share phenotypes with AKAP8L: view

Animal Model Products

miRNA for AKAP8L Gene

miRTarBase miRNAs that target AKAP8L

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKAP8L Gene

Localization for AKAP8L Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP8L Gene

Nucleus. Nucleus matrix. Nucleus speckle. Nucleus, PML body. Cytoplasm. Note=Colocalizes with PRPF40A in the nuclear matrix (PubMed:16391387). Nuclear at steady state but shuttles between the nucleus and cytoplasm (PubMed:10748171). The shuttling property has been questioned (PubMed:11034899). Colocalizes with EBNA-LP in PML bodies (PubMed:11884601). {ECO:0000269 PubMed:10748171, ECO:0000269 PubMed:11034899, ECO:0000269 PubMed:11884601, ECO:0000269 PubMed:16391387}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP8L Gene COMPARTMENTS Subcellular localization image for AKAP8L gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for AKAP8L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS 10761695
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with AKAP8L: view

Pathways & Interactions for AKAP8L Gene

SuperPathways for AKAP8L Gene

PathCards logoMore details on SuperPathways for AKAP8L
genes like me logo Genes that share pathways with AKAP8L: view

Pathways by source for AKAP8L Gene

1 KEGG pathway for AKAP8L Gene

Gene Ontology (GO) - Biological Process for AKAP8L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007076 mitotic chromosome condensation IMP 11034899
GO:0008380 RNA splicing IEA --
GO:0010793 regulation of mRNA export from nucleus IDA 11402034
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 11884601
genes like me logo Genes that share ontologies with AKAP8L: view

No data available for SIGNOR curated interactions for AKAP8L Gene

Drugs & Compounds for AKAP8L Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for AKAP8L Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for AKAP8L Gene

(4) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(447) Selected AceView cDNA sequences:
(20) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AKAP8L Gene

A kinase (PRKA) anchor protein 8-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP8L Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: - -
SP7: -
SP8: - - - - - - -
SP9: - - -
SP10: - -
SP11: - - -
SP12: -
SP13:

ExUns: 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2: -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for AKAP8L Gene

GeneLoc Exon Structure for
AKAP8L
ECgene alternative splicing isoforms for
AKAP8L

Expression for AKAP8L Gene

Products:

  1. Primer

mRNA expression in normal human tissues for AKAP8L Gene

mRNA expression in normal human tissues for AKAP8L Gene
mRNA expression by BioGPS for AKAP8L GenemRNA expression by GTEx for AKAP8L Gene

Protein differential expression in normal tissues from HIPED for AKAP8L Gene

This gene is overexpressed in Bone (16.6), Lung (8.6), Testis (8.1), Peripheral blood mononuclear cells (7.4), and Adrenal (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AKAP8L Gene



SOURCE GeneReport for Unigene cluster for AKAP8L Gene Hs.399800

mRNA Expression by UniProt/SwissProt for AKAP8L Gene

Q9ULX6-AKP8L_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed in the brain cortex (at protein level).
genes like me logo Genes that share expression patterns with AKAP8L: view

Protein tissue co-expression partners for AKAP8L Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AKAP8L Gene

Orthologs for AKAP8L Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP8L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia AKAP8L 35
  • 88.36 (n)
  • 90.95 (a)
AKAP8L 36
  • 90 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia AKAP8L 35
  • 91.42 (n)
  • 93.21 (a)
AKAP8L 36
  • 81 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Akap8l 35
  • 87.9 (n)
  • 90.92 (a)
Akap8l 16
Akap8l 36
  • 90 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia AKAP8L 35
  • 97.32 (n)
  • 96.92 (a)
AKAP8L 36
  • 97 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Akap8l 35
  • 87.48 (n)
  • 90.45 (a)
oppossum
(Monodelphis domestica)
 Mammalia AKAP8L 36
  • 74 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia AKAP8L 36
  • 59 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves AKAP8L 35
  • 69.45 (n)
  • 69.98 (a)
AKAP8L 36
  • 51 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia AKAP8L 36
  • 48 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia akap8l 35
  • 57.32 (n)
  • 53.66 (a)
Str.10140 35
zebrafish
(Danio rerio)
 Actinopterygii wufc52f04 35
akap8l 36
  • 32 (a)
 OneToOne
Species with no ortholog for AKAP8L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKAP8L Gene

ENSEMBL:
Gene Tree for AKAP8L (if available)
TreeFam:
Gene Tree for AKAP8L (if available)

Paralogs for AKAP8L Gene

Paralogs for AKAP8L Gene

(1) SIMAP similar genes for AKAP8L Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with AKAP8L: view

Variants for AKAP8L Gene

Sequence variations from dbSNP and Humsavar for AKAP8L Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2058322 - 15,397,551(+) ATTTG(C/G)TGGAT nc-transcript-variant, reference, missense
rs7256980 -- 15,408,204(+) tccaa(A/G)agtcc intron-variant
rs7257091 -- 15,386,675(+) TTTCT(A/G)AGTTG intron-variant
rs7257156 -- 15,393,955(+) GTGAA(A/G)AAATC intron-variant
rs7260373 -- 15,414,490(+) ttttt(G/T)ttgtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKAP8L Gene

Variant ID Type Subtype PubMed ID
nsv833765 CNV Loss 17160897
nsv911133 CNV Loss 21882294
dgv3746n71 CNV Loss 21882294
nsv828465 CNV Gain 20364138
dgv3747n71 CNV Loss 21882294

Variation tolerance for AKAP8L Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 25.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AKAP8L Gene

Disorders for AKAP8L Gene

MalaCards: The human disease database

(1) MalaCards diseases for AKAP8L Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for AKAP8L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKAP8L
genes like me logo Genes that share disorders with AKAP8L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AKAP8L Gene

Publications for AKAP8L Gene

  1. Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95. (PMID: 10761695) Orstavik S. … Skalhegg B.S. (Biol. Cell 2000) 2 3 4 23 67
  2. A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element. (PMID: 10748171) Westberg C. … Wong-Staal F. (J. Biol. Chem. 2000) 2 3 23
  3. A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. (PMID: 16980585) Li Y. … Lazar M.A. (Genes Dev. 2006) 3 23
  4. In vitro modulation of the interaction between HA95 and LAP2beta by cAMP signaling. (PMID: 12950172) Martins S.B. … Collas P. (Biochemistry 2003) 3 23
  5. cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region. (PMID: 10697960) Seki N. … Muramatsu M.-A. (J. Hum. Genet. 2000) 3 23

Products for AKAP8L Gene

Sources for AKAP8L Gene

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