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Aliases for AKAP8L Gene

Aliases for AKAP8L Gene

  • A Kinase (PRKA) Anchor Protein 8-Like 2 3
  • Homologous To AKAP95 Protein 3 4
  • Neighbor Of AKAP95 3 4
  • AKAP8-Like Protein 3 4
  • NAKAP95 3 4
  • HAP95 3 4
  • NAKAP 3 4
  • HA95 3 4
  • Neighbor Of A Kinase Anchoring Protein 95 2
  • Neighbor Of A-Kinase Anchoring Protein 95 3
  • Neighbor Of A-Kinase-Anchoring Protein 95 4
  • Helicase A-Binding Protein 95 KDa 3
  • Helicase A-Binding Protein 95 4

External Ids for AKAP8L Gene

Previous GeneCards Identifiers for AKAP8L Gene

  • GC19M015352
  • GC19M015353
  • GC19M015490
  • GC19M015058

Summaries for AKAP8L Gene

GeneCards Summary for AKAP8L Gene

AKAP8L (A Kinase (PRKA) Anchor Protein 8-Like) is a Protein Coding gene. Among its related pathways are Epstein-Barr virus infection. GO annotations related to this gene include poly(A) RNA binding and DEAD/H-box RNA helicase binding. An important paralog of this gene is AKAP8.

UniProtKB/Swiss-Prot for AKAP8L Gene

  • Could play a role in constitutive transport element (CTE)-mediated gene expression. Does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta

Gene Wiki entry for AKAP8L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP8L Gene

Genomics for AKAP8L Gene

Regulatory Elements for AKAP8L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AKAP8L Gene

Chromosome:
19
Start:
15,380,048 bp from pter
End:
15,419,141 bp from pter
Size:
39,094 bases
Orientation:
Minus strand

Genomic View for AKAP8L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKAP8L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP8L Gene

Proteins for AKAP8L Gene

  • Protein details for AKAP8L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULX6-AKP8L_HUMAN
    Recommended name:
    A-kinase anchor protein 8-like
    Protein Accession:
    Q9ULX6
    Secondary Accessions:
    • B4DJ74
    • B5BU90
    • O94792
    • Q96J58
    • Q9NRQ0
    • Q9UGM0

    Protein attributes for AKAP8L Gene

    Size:
    646 amino acids
    Molecular mass:
    71649 Da
    Quaternary structure:
    • Interacts with PRPF40A (By similarity). Binds to the C-terminal of RNA helicase A and to TMPO-beta. Interacts with RNF43.
    SequenceCaution:
    • Sequence=AAF86048.1; Type=Frameshift; Positions=553; Evidence={ECO:0000305}; Sequence=BAA34791.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for AKAP8L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKAP8L Gene

Proteomics data for AKAP8L Gene at MOPED

Post-translational modifications for AKAP8L Gene

  • Phosphorylated on serine or threonine residues possibly by PKA.
  • Ubiquitination at Lys 257, Lys 264, and Lys 533
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for AKAP8L Gene

Domains & Families for AKAP8L Gene

Protein Domains for AKAP8L Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULX6

UniProtKB/Swiss-Prot:

AKP8L_HUMAN :
  • Belongs to the AKAP95 family.
  • Contains 2 C2H2 AKAP95-type zinc fingers.
Family:
  • Belongs to the AKAP95 family.
Similarity:
  • Contains 2 C2H2 AKAP95-type zinc fingers.
genes like me logo Genes that share domains with AKAP8L: view

No data available for Gene Families for AKAP8L Gene

Function for AKAP8L Gene

Molecular function for AKAP8L Gene

UniProtKB/Swiss-Prot Function:
Could play a role in constitutive transport element (CTE)-mediated gene expression. Does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta

Gene Ontology (GO) - Molecular Function for AKAP8L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 18313049
GO:0016301 kinase activity --
GO:0017151 DEAD/H-box RNA helicase binding TAS 10748171
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with AKAP8L: view
genes like me logo Genes that share phenotypes with AKAP8L: view

Animal Model Products

miRNA for AKAP8L Gene

miRTarBase miRNAs that target AKAP8L

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKAP8L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for AKAP8L Gene

Localization for AKAP8L Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP8L Gene

Nucleus matrix. Cytoplasm. Note=Colocalizes with PRPF40A in the nuclear matrix (By similarity). Nuclear at steady state but shuttles between the nucleus and cytoplasm. Associated with the nuclear matrix. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP8L Gene COMPARTMENTS Subcellular localization image for AKAP8L gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for AKAP8L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10761695
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016363 nuclear matrix IDA 16391387
genes like me logo Genes that share ontologies with AKAP8L: view

Pathways & Interactions for AKAP8L Gene

SuperPathways for AKAP8L Gene

genes like me logo Genes that share pathways with AKAP8L: view

Pathways by source for AKAP8L Gene

1 KEGG pathway for AKAP8L Gene

Gene Ontology (GO) - Biological Process for AKAP8L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016310 phosphorylation --
genes like me logo Genes that share ontologies with AKAP8L: view

No data available for SIGNOR curated interactions for AKAP8L Gene

Drugs & Compounds for AKAP8L Gene

No Compound Related Data Available

Transcripts for AKAP8L Gene

Unigene Clusters for AKAP8L Gene

A kinase (PRKA) anchor protein 8-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKAP8L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP8L Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: - -
SP7: -
SP8: - - - - - - -
SP9: - - -
SP10: - -
SP11: - - -
SP12: -
SP13:

ExUns: 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2: -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for AKAP8L Gene

GeneLoc Exon Structure for
AKAP8L
ECgene alternative splicing isoforms for
AKAP8L

Expression for AKAP8L Gene

mRNA expression in normal human tissues for AKAP8L Gene

Protein differential expression in normal tissues from HIPED for AKAP8L Gene

This gene is overexpressed in Bone (16.6), Lung (8.6), Testis (8.1), Peripheral blood mononuclear cells (7.4), and Adrenal (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKAP8L Gene



SOURCE GeneReport for Unigene cluster for AKAP8L Gene Hs.399800

mRNA Expression by UniProt/SwissProt for AKAP8L Gene

Q9ULX6-AKP8L_HUMAN
Tissue specificity: Expressed in the brain cortex (at protein level).
genes like me logo Genes that share expression patterns with AKAP8L: view

Protein tissue co-expression partners for AKAP8L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AKAP8L Gene

Orthologs for AKAP8L Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP8L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AKAP8L 35
  • 88.36 (n)
  • 90.95 (a)
AKAP8L 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKAP8L 35
  • 91.42 (n)
  • 93.21 (a)
AKAP8L 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akap8l 35
  • 87.9 (n)
  • 90.92 (a)
Akap8l 16
Akap8l 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AKAP8L 35
  • 97.32 (n)
  • 96.92 (a)
AKAP8L 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akap8l 35
  • 87.48 (n)
  • 90.45 (a)
oppossum
(Monodelphis domestica)
Mammalia AKAP8L 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKAP8L 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves AKAP8L 35
  • 69.45 (n)
  • 69.98 (a)
AKAP8L 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKAP8L 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia akap8l 35
  • 57.32 (n)
  • 53.66 (a)
Str.10140 35
zebrafish
(Danio rerio)
Actinopterygii wufc52f04 35
akap8l 36
  • 32 (a)
OneToOne
Species with no ortholog for AKAP8L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKAP8L Gene

ENSEMBL:
Gene Tree for AKAP8L (if available)
TreeFam:
Gene Tree for AKAP8L (if available)

Paralogs for AKAP8L Gene

Paralogs for AKAP8L Gene

(1) SIMAP similar genes for AKAP8L Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with AKAP8L: view

Variants for AKAP8L Gene

Sequence variations from dbSNP and Humsavar for AKAP8L Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs185701893 -- 15,400,552(+) GCTAT(A/G)TGCCA intron-variant
rs185802145 -- 15,395,013(+) TGCTA(C/T)CACCT intron-variant
rs185812274 -- 15,418,690(+) AGACA(G/T)CAGGC intron-variant
rs185820605 -- 15,408,776(+) CTGAA(G/T)CGGGA intron-variant
rs185830884 -- 15,385,432(+) CACCT(C/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKAP8L Gene

Variant ID Type Subtype PubMed ID
nsv833765 CNV Loss 17160897
nsv911133 CNV Loss 21882294
dgv3746n71 CNV Loss 21882294
nsv828465 CNV Gain 20364138
dgv3747n71 CNV Loss 21882294

Variation tolerance for AKAP8L Gene

Residual Variation Intolerance Score: 34.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 25.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKAP8L Gene

HapMap Linkage Disequilibrium report
AKAP8L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP8L Gene

Disorders for AKAP8L Gene

Relevant External Links for AKAP8L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKAP8L
genes like me logo Genes that share disorders with AKAP8L: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKAP8L Gene

Publications for AKAP8L Gene

  1. Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95. (PMID: 10761695) Orstavik S. … Skalhegg B.S. (Biol. Cell 2000) 2 23 67
  2. A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element. (PMID: 10748171) Westberg C. … Wong-Staal F. (J. Biol. Chem. 2000) 2 23 67
  3. Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105. (PMID: 19531803) Wall E.A. … Fraser I.D. (Sci Signal 2009) 23 67
  4. A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. (PMID: 16980585) Li Y. … Lazar M.A. (Genes Dev. 2006) 23 67
  5. A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association. (PMID: 16227597) Kamada S. … Hunter T. (Mol. Cell. Biol. 2005) 23 67

Products for AKAP8L Gene

Sources for AKAP8L Gene

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