Aliases for AKAP8L Gene
Aliases for AKAP8L Gene
External Ids for AKAP8L Gene
- HGNC: 29857
- Entrez Gene: 26993
- Ensembl: ENSG00000011243
- OMIM: 609475
- UniProtKB: Q9ULX6
Previous GeneCards Identifiers for AKAP8L Gene
- GC19M015352
- GC19M015353
- GC19M015490
- GC19M015058
Summaries for AKAP8L Gene
GeneCards Summary for AKAP8L Gene
AKAP8L (A-Kinase Anchoring Protein 8 Like) is a Protein Coding gene. Among its related pathways are Epstein-Barr virus infection. Gene Ontology (GO) annotations related to this gene include DEAD/H-box RNA helicase binding. An important paralog of this gene is AKAP8.
UniProtKB/Swiss-Prot for AKAP8L Gene
-
Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at Ser-10 of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903).
-
(Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters (PubMed:11884601). Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses (PubMed:11402034). In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity (PubMed:25034436).
Additional gene information for AKAP8L Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP8L Gene
Genomics for AKAP8L Gene
GeneHancer (GH) Regulatory Elements for AKAP8L Gene
Promoters and enhancers for AKAP8L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around AKAP8L on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the AKAP8L gene promoter:
Regulatory Element Products
Genomic Locations for AKAP8L Gene
Genomic Locations for AKAP8L Gene
- chr19:15,380,048-15,419,141
- (GRCh38/hg38)
- Size:
- 39,094 bases
- Orientation:
- Minus strand
- chr19:15,490,859-15,529,952
- (GRCh37/hg19)
Genomic View for AKAP8L Gene
Genes around AKAP8L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.12 by Ensembl
- 19p13.12 by Entrez Gene
- 19p13.12 by HGNC
AKAP8L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AKAP8L Gene
Proteins for AKAP8L Gene
-
Protein details for AKAP8L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9ULX6-AKP8L_HUMAN
- Recommended name:
- A-kinase anchor protein 8-like
- Protein Accession:
- Q9ULX6
- B4DJ74
- B5BU90
- O94792
- Q96J58
- Q9NRQ0
- Q9UGM0
Protein attributes for AKAP8L Gene
- Size:
- 646 amino acids
- Molecular mass:
- 71649 Da
- Quaternary structure:
-
- Interacts (via N-terminus) with DHX9 (via RGG region) (PubMed:10748171, PubMed:11402034). Interacts with TMPO isoform Beta, PRPF40A, RNF43, lamin-B (PubMed:11034899, PubMed:12538639 PubMed:16391387, PubMed:18313049). Interacts with HDAC3; increased during mitosis (PubMed:16980585). Interacts with EBV EBNA-LP (PubMed:11160753). Interacts with HIV-1 reverse transcriptase/ribonuclease H (PubMed:25034436).
- SequenceCaution:
-
- Sequence=AAF86048.1; Type=Frameshift; Positions=553; Evidence={ECO:0000305}; Sequence=BAA34791.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for AKAP8L Gene
Post-translational modifications for AKAP8L Gene
- Phosphorylated on serine or threonine residues possibly by PKA; probably modulating the interaction with TMPO isoform Beta.
- Ubiquitination at posLast=257257, Lys264, and Lys533
Other Protein References for AKAP8L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for AKAP8L
- Invitrogen Antibodies for AKAP8L
- GeneTex AKAP8L antibody for AKAP8L
-
Santa Cruz Biotechnology (SCBT) Antibodies for AKAP8L
Protein Products
-
OriGene Purified Proteins for AKAP8L
- Search Origene for MassSpec and Protein Over-expression Lysates for AKAP8L
- Origene Custom Protein Services for AKAP8L
- antibodies-online: Search results for 3 available AKAP8L Proteins ranked by validation data
- Compare Top AKAP8L Proteins
-
Quality Products:
- Search GeneTex for Proteins for AKAP8L
Assay Products
- antibodies-online: Search results for 2 available AKAP8L Elisa Kits ranked by validation data
- Compare Top AKAP8L Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for AKAP8L Gene
Domains & Families for AKAP8L Gene
Gene Families for AKAP8L Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for AKAP8L Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for AKAP8L Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9ULX6- Family:
-
- Belongs to the AKAP95 family.
Function for AKAP8L Gene
Molecular function for AKAP8L Gene
- UniProtKB/Swiss-Prot Function:
- Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at Ser-10 of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters (PubMed:11884601). Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses (PubMed:11402034). In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity (PubMed:25034436).
Phenotypes From GWAS Catalog for AKAP8L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | HDA,IDA | 22658674 |
| GO:0005515 | protein binding | IPI | 11402034 |
| GO:0005521 | lamin binding | IDA | 11034899 |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for AKAP8L Gene
- GenomeRNAi human phenotypes for AKAP8L:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
- Decreased viability
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Synthetic lethal with vaccinia virus (VACV) infection
- Increased viability with MLN4924 (a NAE inhibitor)
- Downregulation of Wnt pathway after Wnt3A stimulation
- Negative genetic interaction between BLM-/- and BLM+/+
- Apoptosis resistance
- Decreased viability after gemcitabine stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for AKAP8L
-
-
ViGene Biosciences lentiviral particle packaged cDNA for AKAP8L gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AKAP8L gene
- Search ViGene Biosciences for AKAP8L
CRISPR Products
-
OriGene CRISPR knockouts for AKAP8L
- genomics-online: gRNA clones - Search results for available AKAP8L gene related products
- Applied Biological Materials CRISPR for AKAP8L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AKAP8L
- GenScript: Design CRISPR guide RNA sequences for AKAP8L
miRNA for AKAP8L Gene
- miRTarBase miRNAs that target AKAP8L
miRNA Products
- Search ViGene Biosciences for AKAP8L
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for AKAP8L
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-
ViGene Biosciences ready-to-package AAV shRNAs for AKAP8L gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AKAP8L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AKAP8L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for AKAP8L
- genomics-online: cdna clones - Search results for available AKAP8L gene related products
- orf clones - Search results for available AKAP8L gene related products
- Applied Biological Materials Clones for AKAP8L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for AKAP8L
-
ViGene Biosciences adenoviral particle packaged cDNA for AKAP8L gene
-
ViGene Biosciences lentiviral particle packaged cDNA for AKAP8L gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AKAP8L gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKAP8L Gene
Localization for AKAP8L Gene
Subcellular locations from UniProtKB/Swiss-Prot for AKAP8L Gene
- Nucleus. Nucleus matrix. Nucleus speckle. Nucleus, PML body. Cytoplasm. Note=Colocalizes with PRPF40A in the nuclear matrix (PubMed:16391387). Nuclear at steady state but shuttles between the nucleus and cytoplasm (PubMed:10748171). The shuttling property has been questioned (PubMed:11034899). Colocalizes with EBNA-LP in PML bodies (PubMed:11884601). {ECO:0000269 PubMed:10748171, ECO:0000269 PubMed:11034899, ECO:0000269 PubMed:11884601, ECO:0000269 PubMed:16391387}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Nuclear speckles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IDA | 11034899 |
| GO:0005634 | nucleus | TAS,IEA | 10761695 |
| GO:0005737 | cytoplasm | IEA,IDA | 11402034 |
| GO:0016363 | nuclear matrix | IDA,IEA | 11034899 |
| GO:0016605 | PML body | IEA | -- |
Pathways & Interactions for AKAP8L Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Epstein-Barr virus infection | ||
Pathways by source for AKAP8L Gene
1 KEGG pathway for AKAP8L Gene
Interacting Proteins for AKAP8L Gene
Selected Interacting proteins:
Q9ULX6-AKP8L_HUMAN
ENSP00000380557
for AKAP8L Gene via
IID
UniProtKB
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006397 | mRNA processing | IDA,IEA | 17594903 |
| GO:0007076 | mitotic chromosome condensation | IMP | 11034899 |
| GO:0008380 | RNA splicing | IEA | -- |
No data available for SIGNOR curated interactions for AKAP8L Gene
Transcripts for AKAP8L Gene
mRNA/cDNA for AKAP8L Gene
- (4) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (154) Selected AceView cDNA sequences:
- (20) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for AKAP8L Gene
CRISPR Products
-
OriGene CRISPR knockouts for AKAP8L
- genomics-online: gRNA clones - Search results for available AKAP8L gene related products
- Applied Biological Materials CRISPR for AKAP8L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AKAP8L
- GenScript: Design CRISPR guide RNA sequences for AKAP8L
miRNA Products
- Search ViGene Biosciences for AKAP8L
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for AKAP8L
- Browse OriGene Inhibitory RNA Products For AKAP8L
- genomics-online: shRNA clones - Search results for available AKAP8L gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for AKAP8L gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AKAP8L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AKAP8L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for AKAP8L
- genomics-online: cdna clones - Search results for available AKAP8L gene related products
- orf clones - Search results for available AKAP8L gene related products
- Applied Biological Materials Clones for AKAP8L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f | · | 8g | · | 8h | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP8: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||
| SP2: | - | ||||||||||||
| SP3: | - | - | |||||||||||
| SP4: | |||||||||||||
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| SP6: | |||||||||||||
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| SP8: | |||||||||||||
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| SP12: | |||||||||||||
| SP13: |
Expression for AKAP8L Gene
This gene is overexpressed in Bone (16.6), Lung (8.6), Testis (8.1), Peripheral blood mononuclear cells (7.4), and Adrenal (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AKAP8L Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of AKAP8L Gene:
AKAP8LSOURCE GeneReport for Unigene cluster for AKAP8L Gene:
Hs.399800mRNA Expression by UniProt/SwissProt for AKAP8L Gene:
Q9ULX6-AKP8L_HUMAN
Tissue specificity:
Ubiquitously expressed. Expressed in the brain cortex (at protein level).
Evidence on tissue expression from TISSUES for AKAP8L Gene
- Nervous system(5)
- Eye(3.5)
- Lung(2.7)
- Intestine(2.3)
- Adrenal gland(2)
- Pancreas(2)
Primer Products
-
OriGene qPCR primer pairs for AKAP8L
-
OriGene qPCR primer pairs and template standards for AKAP8L
- genomics-online: primer clones - Search results for available AKAP8L gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKAP8L Gene
Orthologs for AKAP8L Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AKAP8L 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | AKAP8L 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | AKAP8L 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Akap8l 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Akap8l 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | AKAP8L 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | AKAP8L 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | AKAP8L 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | AKAP8L 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | akap8l 33 |
|
||
| Str.10140 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | akap8l 34 |
|
OneToOne | |
| wufc52f04 33 |
|
- Species where no ortholog for AKAP8L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for AKAP8L Gene
(1) SIMAP similar genes for AKAP8L Gene using alignment to 8 proteins:
Variants for AKAP8L Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000006524 | -- | 15,390,289(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000076362 | -- | 15,408,840(-) | C/T | intron_variant | |
| rs1000207351 | -- | 15,380,443(-) | G/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000285549 | -- | 15,390,115(-) | AAAAAAAAA/AAAAAAAAAA | genic_downstream_transcript_variant, intron_variant | |
| rs1000377937 | -- | 15,419,374(-) | C/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3643769 | CNV | loss | 21293372 |
| nsv1064684 | CNV | gain | 25217958 |
| nsv828465 | CNV | gain | 20364138 |
| nsv833765 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.31;
25.97% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AKAP8L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AKAP8L
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP8L Gene
Disorders for AKAP8L Gene
Additional Disease Information for AKAP8L
No disorders were found for AKAP8L Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKAP8L Gene
Publications for AKAP8L Gene
- A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element. (PMID: 10748171) Westberg C … Wong-Staal F (The Journal of biological chemistry 2000) 2 3 4 22 58
- Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95. (PMID: 10761695) Orstavik S … Skålhegg BS (Biology of the cell 2000) 2 3 4 22 58
- A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. (PMID: 16980585) Li Y … Lazar MA (Genes & development 2006) 3 4 22 58
- In vitro modulation of the interaction between HA95 and LAP2beta by cAMP signaling. (PMID: 12950172) Martins SB … Collas P (Biochemistry 2003) 3 4 22 58
- cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region. (PMID: 10697960) Seki N … Muramatsu M (Journal of human genetics 2000) 3 4 22 58
Products for AKAP8L Gene
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- GenScript: Next-day shipping of latest version cDNA ORF clones for AKAP8L in any vector
- GenScript Custom Purified and Recombinant Proteins Services for AKAP8L
- GenScript Custom Assay Services for AKAP8L
- GenScript Custom overexpressing Cell Line Services for AKAP8L
- GenScript: Design CRISPR guide RNA sequences for AKAP8L
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for AKAP8L
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for AKAP8L
- Novus Biologicals proteins and lysates for AKAP8L
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for AKAP8L
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for AKAP8L
- VectorBuilder custom plasmid, inducible vectors for AKAP8L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AKAP8L
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for AKAP8L
- antibodies-online: Search results for 48 available AKAP8L Antibodies ranked by validation data
- Compare Top AKAP8L Antibodies
- antibodies-online: Search results for 2 available AKAP8L Elisa Kits ranked by validation data
- Compare Top AKAP8L Elisa Kits
- Quality Products:
- antibodies-online: Search results for 3 available AKAP8L Proteins ranked by validation data
- Compare Top AKAP8L Proteins
- Quality Products:
- GeneTex AKAP8L antibody for AKAP8L
- Search GeneTex for Proteins for AKAP8L
- ViGene Biosciences adenoviral particle packaged cDNA for AKAP8L gene
- ViGene Biosciences lentiviral particle packaged cDNA for AKAP8L gene
- ViGene Biosciences ready-to-package AAV shRNAs for AKAP8L gene
- Search ViGene Biosciences for AKAP8L
- Santa Cruz Biotechnology (SCBT) Antibodies for AKAP8L
- Search Santa Cruz Biotechnology (SCBT) for AKAP8L siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for AKAP8L
- Horizon Cell Lines for AKAP8L
- genomics-online: cdna clones - Search results for available AKAP8L gene related products
- orf clones - Search results for available AKAP8L gene related products
- genomics-online: gRNA clones - Search results for available AKAP8L gene related products
- genomics-online: primer clones - Search results for available AKAP8L gene related products
- genomics-online: shRNA clones - Search results for available AKAP8L gene related products
Sources for AKAP8L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew