Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AKAP8L Gene

protein-coding   GIFtS: 58
GCID: GC19M015490

A Kinase (PRKA) Anchor Protein 8-Like

  Search for AKAP8L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
A Kinase (PRKA) Anchor Protein 8-Like1 2     NAKAP2 3
Neighbor Of A Kinase Anchoring Protein 951 2     NAKAP952 3
Homologous To AKAP95 Protein2 3     AKAP8-Like Protein2 3
Neighbor Of A-Kinase-Anchoring Protein 952 3     A-Kinase Anchor Protein 8-Like2
Neighbor Of AKAP952 3     Helicase A-Binding Protein 95 KDa2
HA952 3     Neighbor Of A-Kinase Anchoring Protein 952
HAP952 3     Helicase A-Binding Protein 953

External Ids:    HGNC: 298571   Entrez Gene: 269932   Ensembl: ENSG000000112437   OMIM: 6094755   UniProtKB: Q9ULX63   

Export aliases for AKAP8L gene to outside databases

Previous GC identifers: GC19M015352 GC19M015353 GC19M015058


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for AKAP8L Gene:
AKAP8L (A kinase (PRKA) anchor protein 8-like) is a protein-coding gene. GO annotations related to this gene include DEAD/H-box RNA helicase binding. An important paralog of this gene is AKAP8.

UniProtKB/Swiss-Prot: AKP8L_HUMAN, Q9ULX6
Function: Could play a role in constitutive transport element (CTE)-mediated gene expression. Does not seem to be
implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and
chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta

Gene Wiki entry for AKAP8L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AKAP8L gene promoter:
         GCNF   Pax-2   Pax-2a   Egr-2   AREB6   PPAR-gamma1   GCNF-1   c-Myb   PPAR-gamma2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAKAP8L promoter sequence
   Search Chromatin IP Primers for AKAP8L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKAP8L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.12

AKAP8L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKAP8L gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M015490:  view genomic region     (about GC identifiers)

Start:
15,490,859 bp from pter      End:
15,529,952 bp from pter
Size:
39,094 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AKP8L_HUMAN, Q9ULX6 (See protein sequence)
Recommended Name: A-kinase anchor protein 8-like  
Size: 646 amino acids; 71649 Da
Subunit: Interacts with PRPF40A (By similarity). Binds to the C-terminal of RNA helicase A and to TMPO-beta.
Interacts with RNF43
Sequence caution: Sequence=AAF86048.1; Type=Frameshift; Positions=553; Sequence=BAA34791.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DJ74 B5BU90 O94792 Q96J58 Q9NRQ0 Q9UGM0
Alternative splicing: 2 isoforms:  Q9ULX6-1   Q9ULX6-2   

Explore the universe of human proteins at neXtProt for AKAP8L: NX_Q9ULX6

Explore proteomics data for AKAP8L at MOPED

Post-translational modifications: 

  • Phosphorylated on serine or threonine residues possibly by PKA1
  • Ubiquitination2 at Lys257, Lys264, Lys533
  • Modification sites at PhosphoSitePlus

  • See AKAP8L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055186.2  
    ENSEMBL proteins: 
     ENSP00000380557   ENSP00000477434   ENSP00000470952   ENSP00000470906   ENSP00000471958  
     ENSP00000470067   ENSP00000472188   ENSP00000470912  

    AKAP8L Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for AKAP8L
    OriGene Protein Over-expression Lysate for AKAP8L
    OriGene MassSpec for AKAP8L
    OriGene Custom Protein Services for AKAP8L
    GenScript Custom Purified and Recombinant Proteins Services for AKAP8L
    Novus Biologicals AKAP8L Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AKAP8L

     
    Search eBioscience for Proteins for AKAP8L 

    AKAP8L Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for AKAP8L
    OriGene Custom Antibody Services for AKAP8L
    Novus Biologicals AKAP8L Antibodies
    Abcam antibodies for AKAP8L
    Cloud-Clone Corp. Antibodies for AKAP8L
    ThermoFisher Antibodies for AKAP8L
    LSBio Antibodies in human, mouse, rat for AKAP8L

    AKAP8L Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AKAP8L
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AKAP8L
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AKAP8L
    Cloud-Clone Corp. CLIAs for AKAP8L
    Search eBioscience for ELISAs for AKAP8L 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR007071 AKAP95
     IPR015880 Znf_C2H2-like

    Graphical View of Domain Structure for InterPro Entry Q9ULX6

    ProtoNet protein and cluster: Q9ULX6

    1 Blocks protein domain: IPB007071 A-kinase anchoring protein 95 (AKAP95)

    UniProtKB/Swiss-Prot: AKP8L_HUMAN, Q9ULX6
    Similarity: Belongs to the AKAP95 family
    Similarity: Contains 2 C2H2 AKAP95-type zinc fingers


    Find genes that share domains with AKAP8L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKP8L_HUMAN, Q9ULX6
    Function: Could play a role in constitutive transport element (CTE)-mediated gene expression. Does not seem to be
    implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and
    chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI18313049
    GO:0017151DEAD/H-box RNA helicase binding TAS10748171
    GO:0044822poly(A) RNA binding IDA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with AKAP8L           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for AKAP8L:
     Decreased Wnt reporter activit  Decreased viability  Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AKAP8L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AKAP8L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AKAP8L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AKAP8L

    miRNA
    Products:
        
    miRTarBase miRNAs that target AKAP8L:
    hsa-mir-378a-5p (MIRT043966), hsa-mir-615-3p (MIRT040300), hsa-mir-31-5p (MIRT049869)

    Block miRNA regulation of human, mouse, rat AKAP8L using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AKAP8L
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AKAP8L
    Predesigned siRNA for gene silencing in human, mouse, rat AKAP8L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AKAP8L

    Clone
    Products:
         
    OriGene clones in human, mouse for AKAP8L (see all 8)
    OriGene ORF clones in mouse, rat for AKAP8L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AKAP8L (NM_014371)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKAP8L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKAP8L
    Addgene plasmids for AKAP8L 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AKAP8L
    Browse ESI BIO Cell Lines and PureStem Progenitors for AKAP8L 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP8L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AKP8L_HUMAN, Q9ULX6: Nucleus matrix. Cytoplasm. Note=Colocalizes with PRPF40A in the nuclear matrix (By
    similarity). Nuclear at steady state but shuttles between the nucleus and cytoplasm. Associated with the nuclear
    matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10761695
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016363nuclear matrix IDA16391387

    Find genes that share ontologies with AKAP8L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for AKAP8L About    
    See pathways by source

    SuperPathContained pathways About
    1Epstein-Barr virus infection
    Epstein-Barr virus infection


    Find genes that share SuperPaths with AKAP8L           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for AKAP8L):
        Epstein-Barr virus infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AKAP8L
    Interactions:

        GeneGlobe Interaction Network for AKAP8L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for AKAP8L (Q9ULX61, 2, 3 ENSP000003805574) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELAQ042062, 3MINT-48011 MINT-48966 I2D: score=1 
    MAP3K3Q997592, 3MINT-48514 I2D: score=2 
    RNF43Q68DV71, 3, ENSP000003853284EBI-357530,EBI-1647060 I2D: score=2 STRING: ENSP00000385328
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    MAGED1Q9Y5V33, ENSP000003648474I2D: score=2 STRING: ENSP00000364847
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with AKAP8L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AKAP8L (AKP8L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AKAP8L gene: 
    NM_014371.2  

    Unigene Cluster for AKAP8L:

    A kinase (PRKA) anchor protein 8-like
    Hs.399800  [show with all ESTs]
    Unigene Representative Sequence: NM_014371
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000397410(uc002naw.1 uc002nax.1 uc010xoh.1 uc002nay.1 uc002naz.3)
    ENST00000609519 ENST00000595465 ENST00000594594 ENST00000593845 ENST00000600065
    ENST00000595087 ENST00000595879 ENST00000596750 ENST00000594893 ENST00000598292
    ENST00000595136 ENST00000599137 ENST00000599488 ENST00000596213 ENST00000597994
    ENST00000596195 ENST00000600247
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AKAP8L using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AKAP8L
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AKAP8L
    Predesigned siRNA for gene silencing in human, mouse, rat AKAP8L
    Clone
    Products:
         
    OriGene clones in human, mouse for AKAP8L (see all 8)
    OriGene ORF clones in mouse, rat for AKAP8L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AKAP8L (NM_014371)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKAP8L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKAP8L
    Addgene plasmids for AKAP8L 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AKAP8L
    OriGene qSTAR qPCR primer pairs in human, mouse for AKAP8L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AKAP8L
      QuantiTect SYBR Green Assays in human, mouse, rat AKAP8L
      QuantiFast Probe-based Assays in human, mouse, rat AKAP8L

    Additional mRNA sequence: 

    AB015332.1 AB025905.1 AB451326.1 AB451469.1 AF199414.1 AJ243467.1 AK094736.1 AK225046.1 
    AK225291.1 AK295956.1 AK310990.1 AL133576.1 BC000713.2 BC111792.1 BC131550.1 

    Selected DOTS entries (see all 28):

    DT.97855002  DT.100671816  DT.95083638  DT.445973  DT.100814161  DT.86847148  DT.121496880  DT.445974 
    DT.95355366  DT.100814160  DT.100814154  DT.100814145  DT.100030475  DT.121496912  DT.100030474  DT.304905 
    DT.40129033  DT.121496925  DT.100814155  DT.91654626  DT.95355361  DT.100814156  DT.100814159  DT.121496748 

    Selected AceView cDNA sequences (see all 447):

    AW025921 CA442269 AI571285 BC048293 AU279721 BM823829 BC000713 BQ000806 
    AL120999 BM453034 BU552799 BQ684563 AI828531 BF439312 AW606676 CA950759 
    BQ773178 BC037270 AI241075 AI304751 AJ243467 AI479138 AI204693 AI677943 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AKAP8L (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^
    SP1:                                                        -                                                                                         -         
    SP2:                                      -                 -                                                                                         -         
    SP3:                                      -                 -                                                                                         -         
    SP4:                                      -                 -                                                                                                   
    SP5:                                      -                 -                                                                                                   

    ExUns: 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
    SP1:        -                                 
    SP2:        -                                 
    SP3:  -     -                                 
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for AKAP8L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AKAP8L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCCCGCA
    AKAP8L Expression
    About this image


    AKAP8L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    AKAP8L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKAP8L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.399800

    UniProtKB/Swiss-Prot: AKP8L_HUMAN, Q9ULX6
    Tissue specificity: Expressed in the brain cortex (at protein level)

        Custom PCR Arrays for AKAP8L
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AKAP8L
    OriGene qSTAR qPCR primer pairs in human, mouse for AKAP8L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AKAP8L
    QuantiTect SYBR Green Assays in human, mouse, rat AKAP8L
    QuantiFast Probe-based Assays in human, mouse, rat AKAP8L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP8L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for AKAP8L gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akap8l1 , 5 A kinase (PRKA) anchor protein 8-like1, 5 87.9(n)1
    90.92(a)1
      17 (17.50 cM)5
    541941  NM_017476.21  NP_059504.21 
     323214245 
    chicken
    (Gallus gallus)
    Aves AKAP8L1 A kinase (PRKA) anchor protein 8-like 69.45(n)
    69.98(a)
      776856  NM_001199537.1  NP_001186466.1 
    lizard
    (Anolis carolinensis)
    Reptilia AKAP8L6
    A kinase (PRKA) anchor protein 8-like
    48(a)
    1 ↔ 1
    2(103451547-103490066)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.101402 Transcribed sequence with weak similarity to protein more 75.17(n)    BX691185.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc52f042 wufc52f04 78.03(n)   325046  BM156308.1 


    ENSEMBL Gene Tree for AKAP8L (if available)
    TreeFam Gene Tree for AKAP8L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for AKAP8L gene
    AKAP82  ZNF3262  
    1 SIMAP similar gene for AKAP8L using alignment to 8 protein entries:     AKP8L_HUMAN (see all proteins):
    DKFZp434L0650

    Find genes that share paralogs with AKAP8L           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for AKAP8L (see all 716)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs23662671,2
    C,F,A,H--15492848(-) ACCCAG/ACAGTG 1 -- int126Minor allele frequency- A:0.27NS EA NA WA 2498
    rs1874041361,2
    --15492865(+) GCTGTC/GGATAA 1 -- int10--------
    rs1379604371,2
    --15492902(+) TCCCAC/TGGCAT 1 -- int10--------
    rs1927001761,2
    --15492903(+) CCCACA/GGCATT 1 -- int10--------
    rs1473737091,2
    C--15493036(+) TTTTT-/TAAAGAC 1 -- int10--------
    rs353952011,2
    C,F--15493037(+) TTTTA-/AGACAG 1 -- int14Minor allele frequency- A:0.38NA CSA 8
    rs571327001,2
    C--15493037(+) TTTTTT/AAGACA 1 -- int12Minor allele frequency- A:0.00NA WA 4
    rs1834316401,2
    --15493399(+) CATTAC/TACTTA 1 -- int10--------
    rs798749501,2
    C--15493461(+) GCATTA/TACTTT 1 -- int10--------
    rs751882261,2
    F--15493548(+) GCTGAT/CGCAGG 1 -- int11Minor allele frequency- C:0.06WA 118

    HapMap Linkage Disequilibrium report for AKAP8L (15490859 - 15529952 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for AKAP8L:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3746n71CNV Loss21882294
    nsv911133CNV Loss21882294
    dgv3747n71CNV Loss21882294
    nsv833765CNV Loss17160897
    nsv828465CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AKAP8L
    DNA2.0 Custom Variant and Variant Library Synthesis for AKAP8L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609475    OMIM disorders: --


    Find genes that share disorders with AKAP8L           About GenesLikeMe


    Export disorders for AKAP8L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AKAP8L gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with AKAP8L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95. (PubMed id 10761695)1, 2, 3, 9 Orstavik S.... Skalhegg B.S. (Biol. Cell 2000)
    2. A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element. (PubMed id 10748171)1, 2, 3, 9 Westberg C.... Wong-Staal F. (J. Biol. Chem. 2000)
    3. In vitro modulation of the interaction between HA95 and LAP2beta by cAMP signaling. (PubMed id 12950172)1, 2, 9 Martins S.B.... Collas P. (Biochemistry 2003)
    4. cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region. (PubMed id 10697960)1, 2, 9 Seki N.... Muramatsu M.-A. (J. Hum. Genet. 2000)
    5. A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95. (PubMed id 18313049)1, 2 Sugiura T.... Miyamoto K. (Exp. Cell Res. 2008)
    6. Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis. (PubMed id 16391387)1, 2 Sayer J.A.... Coghlan V.M. (NeuroMolecular Med. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication. (PubMed id 12538639)1, 2 Martins S.... Collas P. (J. Cell Biol. 2003)
    10. Selection system for genes encoding nuclear-targeted proteins. (PubMed id 9853615)1, 2 Ueki N.... Muramatsu M.-A. (Nat. Biotechnol. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 26993 HGNC: 29857 AceView: AKAP8 Ensembl:ENSG00000011243 euGenes: HUgn26993
    ECgene: AKAP8L Kegg: 26993 H-InvDB: AKAP8L

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for AKAP8L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AKAP8L gene:
    Search GeneIP for patents involving AKAP8L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for AKAP8L   OriGene RNAi products in human, mouse, rat for AKAP8L  
     OriGene qPCR primer pairs and template standards for AKAP8L   OriGene Protein Over-expression Lysate for AKAP8L  
     OriGene MassSpec something-or-other for AKAP8L   OriGene clones in human, mouse for AKAP8L  
     OriGene qSTAR qPCR primer pairs in human, mouse for AKAP8L   OriGene Purified Protein for AKAP8L  
     OriGene ORF clones in mouse, rat for AKAP8L   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AKAP8L   OriGene Custom Protein Services for AKAP8L  

     
     
     Block miRNA regulation of human, mouse, rat AKAP8L using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AKAP8L
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKAP8L Predesigned siRNA for gene silencing in human, mouse, rat AKAP8L
     QuantiFast Probe-based Assays in human, mouse, rat AKAP8L QuantiTect SYBR Green Assays in human, mouse, rat AKAP8L
     Custom PCR Arrays for AKAP8L Search Chromatin IP Primers for AKAP8L
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AKAP8L  GeneGlobe Interaction Network for AKAP8L
     Regulatory tfbs in AKAP8L promoter
     GenScript Custom Purified and Recombinant Proteins Services for AKAP8L GenScript cDNA clones with any tag delivered in your preferred vector for AKAP8L
     GenScript Custom Assay Services for AKAP8L GenScript Custom overexpressing Cell Line Services for AKAP8L
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for AKAP8L (AKP8L)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     AKAP8L antibodies
     AKAP8L lysates
     Antibodies for AKAP8L
     See all of Abcam's Antibodies, Kits and Proteins for AKAP8L
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for AKAP8L
     Antibodies for AKAP8L
     ELISAs for AKAP8L
     CLIAs for AKAP8L



     Browse ESI BIO Cell Lines and PureStem Progenitors for AKAP8L
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP8L
     Browse SwitchGear 3'UTR luciferase reporter plasmids for AKAP8L
     SwitchGear Promoter luciferase reporter plasmids for AKAP8L
     ThermoFisher Antibodies for AKAP8L
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKAP8L
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AKAP8L
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AKAP8L
     LSBio Antibodies in human, mouse, rat for AKAP8L
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for AKAP8L
      Search eBioscience for proteins for AKAP8L
      Search eBioscience for elisas for AKAP8L
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AKAP8L gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4