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Aliases for AKAP8 Gene

Aliases for AKAP8 Gene

  • A Kinase (PRKA) Anchor Protein 8 2 3
  • AKAP 95 3 4
  • AKAP-8 3 4
  • AKAP95 3 4
  • A-Kinase Anchor Protein, 95kDa 3
  • A-Kinase Anchor Protein 95 KDa 4
  • A-Kinase Anchor Protein 2
  • AKAP-95 3
  • 95kDa 2

External Ids for AKAP8 Gene

Previous GeneCards Identifiers for AKAP8 Gene

  • GC19M015843
  • GC19M015309
  • GC19M015325
  • GC19M015464
  • GC19M015032

Summaries for AKAP8 Gene

Entrez Gene Summary for AKAP8 Gene

  • This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]

GeneCards Summary for AKAP8 Gene

AKAP8 (A Kinase (PRKA) Anchor Protein 8) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and G Protein Signaling Pathways. GO annotations related to this gene include poly(A) RNA binding and protein kinase A regulatory subunit binding. An important paralog of this gene is AKAP8L.

UniProtKB/Swiss-Prot for AKAP8 Gene

  • Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II)

Gene Wiki entry for AKAP8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP8 Gene

Genomics for AKAP8 Gene

Regulatory Elements for AKAP8 Gene

Genomic Location for AKAP8 Gene

Chromosome:
19
Start:
15,353,385 bp from pter
End:
15,379,828 bp from pter
Size:
26,444 bases
Orientation:
Minus strand

Genomic View for AKAP8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKAP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP8 Gene

Proteins for AKAP8 Gene

  • Protein details for AKAP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43823-AKAP8_HUMAN
    Recommended name:
    A-kinase anchor protein 8
    Protein Accession:
    O43823

    Protein attributes for AKAP8 Gene

    Size:
    692 amino acids
    Molecular mass:
    76108 Da
    Quaternary structure:
    • Binds to dimeric RII-alpha regulatory subunit of PKA during mitosis. Interacts (via C-terminus) with FIGN (By similarity).

neXtProt entry for AKAP8 Gene

Proteomics data for AKAP8 Gene at MOPED

Post-translational modifications for AKAP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKAP8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AKAP8 Gene

Domains & Families for AKAP8 Gene

Gene Families for AKAP8 Gene

Protein Domains for AKAP8 Gene

Suggested Antigen Peptide Sequences for AKAP8 Gene

Graphical View of Domain Structure for InterPro Entry

O43823

UniProtKB/Swiss-Prot:

AKAP8_HUMAN :
  • Belongs to the AKAP95 family.
  • Contains 2 C2H2 AKAP95-type zinc fingers.
Family:
  • Belongs to the AKAP95 family.
Similarity:
  • Contains 2 C2H2 AKAP95-type zinc fingers.
genes like me logo Genes that share domains with AKAP8: view

Function for AKAP8 Gene

Molecular function for AKAP8 Gene

GENATLAS Biochemistry:
A kinase (PRKA regulatory subunit RIIA) anchor protein 8,located in the nucleus in quiescent fibroblasts,excluding RIIA,suggesting that the interaction is cell cycle dependent,homolog to rat AKAP95
UniProtKB/Swiss-Prot Function:
Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II)

Gene Ontology (GO) - Molecular Function for AKAP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003690 double-stranded DNA binding IEA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0034237 protein kinase A regulatory subunit binding IPI 17911601
genes like me logo Genes that share ontologies with AKAP8: view
genes like me logo Genes that share phenotypes with AKAP8: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKAP8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for AKAP8 Gene

Localization for AKAP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP8 Gene

Nucleus matrix. Note=Associated with the nuclear matrix. Redistributed and detached from condensed chromatin during mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP8 Gene COMPARTMENTS Subcellular localization image for AKAP8 gene
Compartment Confidence
nucleus 5
golgi apparatus 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for AKAP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001939 female pronucleus IEA --
GO:0005634 nucleus TAS 9473338
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with AKAP8: view

Pathways & Interactions for AKAP8 Gene

genes like me logo Genes that share pathways with AKAP8: view

Pathways by source for AKAP8 Gene

Gene Ontology (GO) - Biological Process for AKAP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division TAS 9473338
GO:0007165 signal transduction TAS 9473338
genes like me logo Genes that share ontologies with AKAP8: view

No data available for SIGNOR curated interactions for AKAP8 Gene

Drugs & Compounds for AKAP8 Gene

(4) Drugs for AKAP8 Gene - From: NovoSeek, HMDB, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
cyclic amp Experimental Pharma 0
PKA inhibitor fragment (6-22) amide Pharma Potent protein kinase A inhibitor 0
threonine Nutra 16
genes like me logo Genes that share compounds with AKAP8: view

Transcripts for AKAP8 Gene

Unigene Clusters for AKAP8 Gene

A kinase (PRKA) anchor protein 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKAP8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP8 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2: - - -
SP3: - - - - -
SP4:

Relevant External Links for AKAP8 Gene

GeneLoc Exon Structure for
AKAP8
ECgene alternative splicing isoforms for
AKAP8

Expression for AKAP8 Gene

mRNA expression in normal human tissues for AKAP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AKAP8 Gene

This gene is overexpressed in Adrenal (19.4) and Peripheral blood mononuclear cells (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKAP8 Gene



SOURCE GeneReport for Unigene cluster for AKAP8 Gene Hs.594496

mRNA Expression by UniProt/SwissProt for AKAP8 Gene

O43823-AKAP8_HUMAN
Tissue specificity: Highly expressed in heart, liver, skeletal muscle, kidney and pancreas
genes like me logo Genes that share expression patterns with AKAP8: view

Protein tissue co-expression partners for AKAP8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for AKAP8 Gene

Orthologs for AKAP8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AKAP8 35
  • 85.46 (n)
  • 85.9 (a)
AKAP8 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKAP8 35
  • 83.58 (n)
  • 82.99 (a)
AKAP8 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akap8 35
  • 81.54 (n)
  • 79.88 (a)
Akap8 16
Akap8 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AKAP8 35
  • 99.08 (n)
  • 98.62 (a)
AKAP8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akap8 35
  • 81.65 (n)
  • 80.73 (a)
oppossum
(Monodelphis domestica)
Mammalia AKAP8 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
chicken
(Gallus gallus)
Aves AKAP8 35
  • 67.15 (n)
  • 60.24 (a)
lizard
(Anolis carolinensis)
Reptilia AKAP8 36
  • 54 (a)
OneToOne
Species with no ortholog for AKAP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AKAP8 Gene

ENSEMBL:
Gene Tree for AKAP8 (if available)
TreeFam:
Gene Tree for AKAP8 (if available)

Paralogs for AKAP8 Gene

Paralogs for AKAP8 Gene

(1) SIMAP similar genes for AKAP8 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for AKAP8 Gene

genes like me logo Genes that share paralogs with AKAP8: view

Variants for AKAP8 Gene

Sequence variations from dbSNP and Humsavar for AKAP8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs113686588 -- 15,370,757(+) CTCCC(A/G)AGTAG intron-variant
rs113570027 -- 15,359,021(+) CTCTT(A/G)GCCAC synonymous-codon, reference, nc-transcript-variant
rs113555483 -- 15,377,268(+) GGGAC(C/T)TTGGC intron-variant
rs113516916 -- 15,370,618(+) TTTAC(C/G)CAATG intron-variant
rs113475650 -- 15,361,750(+) TTTTG(G/T)TTTTG missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for AKAP8 Gene

Variant ID Type Subtype PubMed ID
nsv833765 CNV Loss 17160897
nsv911133 CNV Loss 21882294

Variation tolerance for AKAP8 Gene

Residual Variation Intolerance Score: 82.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 51.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKAP8 Gene

HapMap Linkage Disequilibrium report
AKAP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP8 Gene

Disorders for AKAP8 Gene

Relevant External Links for AKAP8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKAP8
genes like me logo Genes that share disorders with AKAP8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKAP8 Gene

Publications for AKAP8 Gene

  1. Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95. (PMID: 9473338) Eide T. … Tasken K. (Exp. Cell Res. 1998) 2 23 67
  2. A-kinase anchoring in dendritic cells is required for antigen presentation. (PMID: 19277197) Schillace R.V. … Carr D.W. (PLoS ONE 2009) 23 67
  3. G1/S Cyclins interact with regulatory subunit of PKA via A-kinase anchoring protein, AKAP95. (PMID: 16721056) Arsenijevic T. … Pirson I. (Cell Cycle 2006) 23 67
  4. AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors. (PMID: 16866877) Ishizaki R. … Nakayama K. (Genes Cells 2006) 23 67
  5. A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association. (PMID: 16227597) Kamada S. … Hunter T. (Mol. Cell. Biol. 2005) 23 67

Products for AKAP8 Gene

Sources for AKAP8 Gene

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