Aliases for AKAP8 Gene
External Ids for AKAP8 Gene
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
GeneCards Summary for AKAP8 Gene
AKAP8 (A Kinase (PRKA) Anchor Protein 8) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include double-stranded DNA binding and protein kinase A regulatory subunit binding. An important paralog of this gene is AKAP8L.
UniProtKB/Swiss-Prot for AKAP8 Gene
Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II)