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AKAP8 Gene

protein-coding   GIFtS: 62
GCID: GC19M015464

A Kinase (PRKA) Anchor Protein 8

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
A Kinase (PRKA) Anchor Protein 81 2     A-Kinase Anchor Protein1
AKAP-82 3     AKAP-952
AKAP952 3     A-Kinase Anchor Protein 82
AKAP 952 3     A-Kinase Anchor Protein, 95kDa2
95kDa1     A-Kinase Anchor Protein 95 KDa3

External Ids:    HGNC: 3781   Entrez Gene: 102702   Ensembl: ENSG000001051277   OMIM: 6046925   UniProtKB: O438233   

Export aliases for AKAP8 gene to outside databases

Previous GC identifers: GC19M015843 GC19M015309 GC19M015325 GC19M015032


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AKAP8 Gene:
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins
that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other
signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that
binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting
PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome
9. (provided by RefSeq, May 2011)

GeneCards Summary for AKAP8 Gene:
AKAP8 (A kinase (PRKA) anchor protein 8) is a protein-coding gene. Diseases associated with AKAP8 include polycystic kidney disease, and kidney disease. GO annotations related to this gene include protein kinase A regulatory subunit binding and double-stranded DNA binding. An important paralog of this gene is AKAP8L.

UniProtKB/Swiss-Prot: AKAP8_HUMAN, O43823
Function: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA
type II)

Gene Wiki entry for AKAP8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AKAP8 gene promoter:
         Pax-5   p53   LUN-1   Nkx2-5   Tal-1beta   FOXO3b   HOXA5   ZID   ITF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAKAP8 promoter sequence
   Search Chromatin IP Primers for AKAP8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKAP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.12

AKAP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKAP8 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M015464:  view genomic region     (about GC identifiers)

Start:
15,464,196 bp from pter      End:
15,490,612 bp from pter
Size:
26,417 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AKAP8_HUMAN, O43823 (See protein sequence)
Recommended Name: A-kinase anchor protein 8  
Size: 692 amino acids; 76108 Da
Subunit: Binds to dimeric RII-alpha regulatory subunit of PKA during mitosis. Interacts (via C-terminus) with FIGN
(By similarity)

Explore the universe of human proteins at neXtProt for AKAP8: NX_O43823

Explore proteomics data for AKAP8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AKAP8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005849.1  
    ENSEMBL proteins: 
     ENSP00000269701   ENSP00000469908   ENSP00000468902  

    AKAP8 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AKAP: A-kinase anchor proteins

    2 InterPro protein domains:
     IPR007071 AKAP95
     IPR015880 Znf_C2H2-like

    Graphical View of Domain Structure for InterPro Entry O43823

    ProtoNet protein and cluster: O43823

    1 Blocks protein domain: IPB007071 A-kinase anchoring protein 95 (AKAP95)

    UniProtKB/Swiss-Prot: AKAP8_HUMAN, O43823
    Similarity: Belongs to the AKAP95 family
    Similarity: Contains 2 C2H2 AKAP95-type zinc fingers


    AKAP8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKAP8_HUMAN, O43823
    Function: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA
    type II)

         Genatlas biochemistry entry for AKAP8:
    A kinase (PRKA regulatory subunit RIIA) anchor protein 8,located in the nucleus in quiescent fibroblasts,excluding
    RIIA,suggesting that the interaction is cell cycle dependent,homolog to rat AKAP95

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0034237protein kinase A regulatory subunit binding IEA--
         
    AKAP8 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for AKAP8:
     Decreased telomerase activity  G0/1 arrest  Increased G1 DNA content 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Akap8):
     craniofacial  digestive/alimentary  homeostasis/metabolism  mortality/aging  normal 
     respiratory system 

    AKAP8 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AKAP8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AKAP8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AKAP8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AKAP8

    miRNA
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    miRTarBase miRNAs that target AKAP8:
    hsa-let-7b-5p (MIRT001654), hsa-mir-92b-3p (MIRT040654), hsa-let-7d-5p (MIRT032126), hsa-mir-218-5p (MIRT024227)

    Block miRNA regulation of human, mouse, rat AKAP8 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate AKAP8:
    hsa-miR-526b hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidAKAP8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AKAP8

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AKAP8_HUMAN, O43823: Nucleus matrix. Note=Associated with the nuclear matrix. Redistributed and detached from
    condensed chromatin during mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    golgi apparatus2
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000793condensed chromosome IEA--
    GO:0001939female pronucleus IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IEA--

    AKAP8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AKAP8 About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    3TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    4Signal transduction PKA signaling
    Signal transduction PKA signaling
    5Cell cycle Chromosome condensation in prometaphase
    Cell cycle Chromosome condensation in prometaphase

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AKAP8
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    2 GeneGo (Thomson Reuters) Pathways for AKAP8
        Cell cycle Chromosome condensation in prometaphase
    Signal transduction PKA signaling

    2 BioSystems Pathways for AKAP8
        G Protein Signaling Pathways
    TNF-alpha/NF-kB Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AKAP8
    Interactions:

        GeneGlobe Interaction Network for AKAP8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for AKAP8 (O438232, 3 ENSP000002697014) via UniProtKB, MINT, STRING, and/or I2D (see all 583)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX5P178442, 3, ENSP000002257924MINT-7947479 I2D: score=3 STRING: ENSP00000225792
    DMAP1Q9NPF52, 3MINT-7947479 I2D: score=1 
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    ENSG00000230336Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis TAS9473338
    GO:0007076mitotic chromosome condensation IEA--
    GO:0007165signal transduction TAS9473338

    AKAP8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AKAP8

    1 HMDB Compound for AKAP8    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    2 Novoseek inferred chemical compound relationships for AKAP8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 26.8 2 11591814 (2)
    zinc 14.5 3 11964380 (2), 10697960 (1)



    AKAP8 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AKAP8 gene: 
    NM_005858.3  

    Unigene Cluster for AKAP8:

    A kinase (PRKA) anchor protein 8
    Hs.594496  [show with all ESTs]
    Unigene Representative Sequence: NM_005858
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269701(uc010dzy.3 uc002nav.3 uc010dzz.1) ENST00000598597
    ENST00000537303(uc010xog.2) ENST00000599883 ENST00000595416
    miRNA
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    Block miRNA regulation of human, mouse, rat AKAP8 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate AKAP8:
    hsa-miR-526b hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidAKAP8 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKAP8
    Primer
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    OriGene qPCR primer pairs and template standards for AKAP8
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AKAP8
      QuantiTect SYBR Green Assays in human, mouse, rat AKAP8
      QuantiFast Probe-based Assays in human, mouse, rat AKAP8

    Additional mRNA sequence: 

    AK303640.1 AK308251.1 AK309529.1 AL050160.1 BC037270.2 Y11997.1 

    7 DOTS entries:

    DT.313147  DT.95265881  DT.97810454  DT.91866697  DT.40273193  DT.40205408  DT.95215098 

    Selected AceView cDNA sequences (see all 447):

    BF061803 BU931073 BP363763 BM718304 AW014702 AI830069 BE312479 AI421203 
    AI083553 AI277701 AJ243467 BM724556 AI089392 AI828531 BP361866 AI281158 
    BU168477 AI203324 AW203981 CA442269 BQ000806 AA405011 BC007551 AI971074 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for AKAP8    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                    -                                                                                             
    SP2:                    -                 -     -                                                                     
    SP3:              -     -     -     -     -                                                                           
    SP4:                                                                                                                  


    ECgene alternative splicing isoforms for AKAP8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AKAP8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGCCTTA
    AKAP8 Expression
    About this image


    AKAP8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Lung (Respiratory System)
             Stem Bronchi
     
     Kidney (Urinary System)
             Metanephros
    AKAP8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKAP8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.594496

    UniProtKB/Swiss-Prot: AKAP8_HUMAN, O43823
    Tissue specificity: Highly expressed in heart, liver, skeletal muscle, kidney and pancreas

        Custom PCR Arrays for AKAP8
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    QuantiFast Probe-based Assays in human, mouse, rat AKAP8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AKAP8 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akap81 , 5 A kinase (PRKA) anchor protein 81, 5 81.54(n)1
    79.88(a)1
      17 (17.48 cM)5
    563991  NM_019774.41  NP_062748.21 
     323036765 
    chicken
    (Gallus gallus)
    Aves AKAP81 A kinase (PRKA) anchor protein 8 67.15(n)
    60.24(a)
      426167  XM_004950032.1  XP_004950089.1 
    lizard
    (Anolis carolinensis)
    Reptilia AKAP86
    A kinase (PRKA) anchor protein 8
    54(a)
    1 ↔ 1
    2(103420049-103448729)


    ENSEMBL Gene Tree for AKAP8 (if available)
    TreeFam Gene Tree for AKAP8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AKAP8 gene
    AKAP8L2  ZNF3262  
    1 SIMAP similar gene for AKAP8 using alignment to 4 protein entries:     AKAP8_HUMAN (see all proteins):
    DKFZp586B1222

    AKAP8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for AKAP8
    PGOHUM00000235963


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AKAP8 (see all 723)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365344
    A breast cancer sample4--see VAR_0365342 Q H mis40--------
    rs351327311,2
    C--15032712(+) TATAT-/ATTACAG 1 -- ut311Minor allele frequency- AT:0.00NA 2
    rs355754591,2
    C,F--15463852(+) TTTTGG/TATTTT 1 -- ds50013Minor allele frequency- T:0.50NA 6
    rs1852605891,2
    --15463853(+) TTTGTA/GTTTTT 1 -- ds50010--------
    rs1884184471,2
    --15463899(+) GTCTTA/GAACTC 1 -- ds50010--------
    rs1812336811,2
    --15463927(+) ACCTGC/TGTTGG 1 -- ds50010--------
    rs1509323281,2
    --15463946(+) AGTGCC/TAGGAA 1 -- ds50010--------
    rs1849033881,2
    --15463949(+) GCCAGG/TAATAC 1 -- ds50010--------
    rs1883482211,2
    --15464090(+) GATCAC/GGCCAC 1 -- ds50010--------
    rs81025071,2
    C,F,A,H--15464149(+) aaaaaA/Gaaaaa 1 -- ds500112Minor allele frequency- G:0.17NS WA CSA 1811

    HapMap Linkage Disequilibrium report for AKAP8 (15464196 - 15490612 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AKAP8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911133CNV Loss21882294
    nsv833765CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604692    OMIM disorders: --

    8 diseases for AKAP8:    
    About MalaCards
    polycystic kidney disease    kidney disease    labyrinthitis    breast and colorectal cancer
    hiv-1    colorectal cancer    cerebritis    breast cancer


    AKAP8 for disorders           About GeneDecksing


    Export disorders for AKAP8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AKAP8 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with AKAP8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95. (PubMed id 9473338)1, 2, 3, 9 Eide T.... Tasken K. (Exp. Cell Res. 1998)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract. (PubMed id 10791967)1, 9 Steen R.L....Collas P. (J. Cell Biol. 2000)
    5. Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting. (PubMed id 11964380)1, 9 Eide T....Collas P. (EMBO Rep. 2002)
    6. A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95. (PubMed id 14641107)1, 9 Arsenijevic T....Pirson I. (Biochem. J. 2004)
    7. A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association. (PubMed id 16227597)1, 9 Kamada S....Hunter T. (Mol. Cell. Biol. 2005)
    8. AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. (PubMed id 12414807)1, 9 Furusawa M....Ariga H. (J. Biol. Chem. 2002)
    9. A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines. (PubMed id 15470020)1, 9 Asirvatham A.L.... Carr D.W. (J. Immunol. 2004)
    10. A-kinase anchoring in dendritic cells is required for antigen presentation. (PubMed id 19277197)1, 9 Schillace R.V....Carr D.W. (PLoS ONE 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10270 HGNC: 378 AceView: AKAP8 Ensembl:ENSG00000105127 euGenes: HUgn10270
    ECgene: AKAP8 H-InvDB: AKAP8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AKAP8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AKAP8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AKAP8 gene:
    Search GeneIP for patents involving AKAP8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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