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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AKAP7 Gene

protein-coding   GIFtS: 59
GCID: GC06P131508

A kinase (PRKA) anchor protein 7
 Explore 2 diseases affiliated with
AKAP7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AKAP7    

Aliases
for AKAP7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
A Kinase (PRKA) Anchor Protein 71 2     PRKA7 Isoform Gamma2 3
AKAP151 2 3     PRKA7 Isoforms Alpha/Beta2 3
AKAP181 2 3     A-Kinase Anchor Protein 7 Isoform Gamma2
A-Kinase Anchor Protein 18 KDa2 3     A-Kinase Anchor Protein 7 Isoforms Alpha And Beta2
AKAP 182 3     A-Kinase Anchor Protein 9 KDa2
AKAP-7 Isoform Gamma2 3     Protein Kinase A-Anchoring Protein 7 Isoform Gamma3
AKAP-7 Isoforms Alpha And Beta2 3     Protein Kinase A-Anchoring Protein 7 Isoforms Alpha/Beta3

External Ids:    HGNC: 3771   Entrez Gene: 94652   Ensembl: ENSG000001185077   OMIM: 6046935   UniProtKB: O436873   
UniProtKB: Q9P0M23   

Export aliases for AKAP7 gene to outside databases

Previous GC identifers: GC06P131126 GC06P131313 GC06P131447 GC06P129047


Summaries
for AKAP7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AKAP7:
This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins
that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific
subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible
for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding
different isoforms have been described.(provided by RefSeq, Apr 2011)

UniProtKB/Swiss-Prot: AKA7G_HUMAN, Q9P0M2
Function: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The
membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may
negatively regulate ENaC channel feedback inhibition by intracellular sodium

Gene Wiki entry for AKAP7


Genomic Views
for AKAP7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AKAP7 gene promoter:
         LHX3b/Lhx3b   Pbx1a   AP-1   Brachyury   CUTL1   GATA-1   HEN1   c-Myb   LHX3a/Lhx3a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AKAP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for AKAP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKAP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23.2

AKAP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKAP7 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P131508:  view genomic region     (about GC identifiers)

Start:
 131,456,806 bp from pter      End:
 131,604,675 bp from pter
Size:
 147,870 bases      Orientation:
 plus strand

Proteins
for AKAP7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AKA7A_HUMAN, O43687 (See protein sequence)
Recommended Name: A-kinase anchor protein 7 isoforms alpha and beta  
Size: 104 amino acids; 11465 Da
Subunit: Binds cAMP-dependent protein kinase (PKA). Interacts with PRKCA; only the cytoplasmic form is capable of
interacting with PRKCA
Subcellular location: Isoform Alpha: Lateral cell membrane; Lipid-anchor. Note=Targeted predominantly to the lateral
membrane
Subcellular location: Isoform Beta: Apical cell membrane; Lipid-anchor. Note=Targeted predominantly to the apical
membrane
Secondary accessions: A8K2K6 Q5TBR9 Q5TBS0 Q9HCZ8 Q9P0G4
Alternative splicing: 3 isoforms:  O43687-1   O43687-2   Q9P0M2-1   

UniProtKB/Swiss-Prot: AKA7G_HUMAN, Q9P0M2 (See protein sequence)

Recommended Name: A-kinase anchor protein 7 isoform gamma  
Size: 348 amino acids; 39518 Da
Subunit: Binds cAMP-dependent protein kinase (PKA). Interacts with PRKCA; only the cytoplasmic form is capable of
interacting with PRKCA
Subcellular location: Nucleus (By similarity). Cytoplasm
Sequence caution: Sequence=AAF28106.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAI19003.1; Type=Erroneous gene model prediction; Sequence=CAI19788.1; Type=Erroneous gene model prediction;
Sequence=CAI21509.1; Type=Erroneous gene model prediction;
Secondary accessions: B4DUC3 Q9HCZ8
Alternative splicing: 3 isoforms:  Q9P0M2-1   O43687-2   O43687-1   

Explore the universe of human proteins at neXtProt for AKAP7: NX_Q9P0M2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P0M2

    • AKAP7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_004833.1  NP_057461.2  NP_619539.1  

    ENSEMBL proteins: 
     ENSP00000405252   ENSP00000441048   ENSP00000445486   ENSP00000446022   ENSP00000263050  
     ENSP00000345149   ENSP00000418208   ENSP00000357105  

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    Novus Biologicals AKAP7 Proteins
    Novus Biologicals AKAP7 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for AKAP7
    Uscn Proteins for AKAP7

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005624membrane fraction ----
    GO:0005625soluble fraction ----
    GO:0005626insoluble fraction ----
    GO:0005634nucleus IEA--


    AKAP7 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for AKAP7

    Protein Domains /
    Families
    for AKAP7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AKAP7 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR019510 Kinase-A_anchor_nucl_local_sig
     IPR019511 Kinase-A_anchor_RI-RII-bd_dom
     IPR009097 RNA_ligase/cNuc_Pdiesterase

    Graphical View of Domain Structure for InterPro Entry O43687
    Graphical View of Domain Structure for InterPro Entry Q9P0M2

    ProtoNet protein and cluster: O43687


    Function
    for AKAP7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AKA7A_HUMAN, O43687
    Function: Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to
    the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas
    the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium

         UniProtKB/Swiss-Prot: AKA7G_HUMAN, Q9P0M2
    Function: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The
    membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may
    negatively regulate ENaC channel feedback inhibition by intracellular sodium

         Genatlas biochemistry entry for AKAP7:
    A kinase (PRKA regulatory subunit RIIA) anchor protein 7,potentially involved in ion channel activation

    miRNA
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    hsa-miR-3130-5p hsa-miR-217 hsa-miR-148b hsa-miR-181c hsa-miR-301a hsa-miR-1297 hsa-miR-130b hsa-miR-26b
    SwitchGear 3'UTR luciferase reporter plasmid: AKAP7 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity IEA--
    GO:0005515protein binding IPI17244820
    GO:0008022protein C-terminus binding IEA--
    GO:0016208AMP binding IEA--
    GO:0019901protein kinase binding IEA--


    AKAP7 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for AKAP7:
     Decreased cilium length  Decreased cilium length after   Increased apoptosis 

    Animal Models:
         Mouse knock-out Akap7tm1.1Gsm for AKAP7
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Akap7):
     no phenotypic analysis  normal 

    AKAP7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for AKAP7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		Activation of PKA through GPCR0.71
    		cAMP Pathway0.77
    		PKA Signaling0.56
    2G Protein Signaling Pathways
    		G Protein Signaling Pathways1.00
    		Signal transduction_PKA signaling0.23
    		Signal transduction PKA signaling0.23

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for AKAP7
        Signal transduction PKA signaling

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AKAP7
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 GeneGo (Thomson Reuters) Pathway for AKAP7
        Signal transduction PKA signaling

    1 BioSystems Pathway for AKAP7 
        G Protein Signaling Pathways



    AKAP7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AKAP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for AKAP7 (Q9P0M23 ENSP000003571054) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP4ENSP000002655604STRING: ENSP00000265560
    PRKAR1AENSP000003514104STRING: ENSP00000351410
    PRKAR2AENSP000002655634STRING: ENSP00000265563
    PLNENSP000003501324STRING: ENSP00000350132
    MEPCEENSP000003085464STRING: ENSP00000308546
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS9545239
    GO:0008104protein localization IC9545239
    GO:0008150biological_process ND--
    GO:0010738regulation of protein kinase A signaling cascade IEA--
    GO:0016070RNA metabolic process IEA--


    AKAP7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AKAP7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AKAP7

    2 HMDB Compounds for AKAP7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Search CenterWatch for drugs/clinical trials and news about AKAP7 / AKA7G 

    Transcripts
    for AKAP7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AKAP7 gene (3 alternative transcripts): 
    NM_004842.3  NM_016377.3  NM_138633.2  

    Unigene Cluster for AKAP7:

    A kinase (PRKA) anchor protein 7
    Hs.486483  [show with all ESTs]
    Unigene Representative Sequence: NM_016377
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431975(uc003qck.3) ENST00000541650 ENST00000366358 ENST00000479599
    ENST00000543815 ENST00000535150 ENST00000537868 ENST00000263050 ENST00000342266(uc003qcm.2 uc003qcn.2)
    ENST00000474850 ENST00000368123

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKAP7
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate AKAP7 (see all 30):
    hsa-miR-3130-5p hsa-miR-217 hsa-miR-148b hsa-miR-181c hsa-miR-301a hsa-miR-1297 hsa-miR-130b hsa-miR-26b
    SwitchGear 3'UTR luciferase reporter plasmid: AKAP7 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKAP7 (see all 7)
    OriGene shRNA RFP: AKAP7
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKAP7
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): AKAP7 (NM_016377)
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    Additional cDNA sequence: 

    AB451273.1 AB451400.1 AF152929.1 AF161075.1 AK290271.1 AK300587.1 AK311820.1 BC016927.1 
    BC063499.1 BC073847.1 BC094732.1 BC110897.1 BC118601.1 BC118606.1 BC128398.1 BC128399.1 
    BC141926.1 BC141927.1 

    7 DOTS entries:

    DT.95168642  DT.100893038  DT.95168640  DT.91734681  DT.91734687  DT.121353614  DT.121353629 

    24/111 AceView cDNA sequences (see all 111):

    CA412227 CF552349 BI522503 BM354051 F09550 CK820028 CR618092 BX420398 
    AI554010 F03152 CF552329 BE501560 CD636473 BC073847 BC016927 AA256801 
    BC063499 BG105437 AL537713 AU107912 NM_138633 AW236482 BF058265 NM_016377 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for AKAP7    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                            -                     
    SP4:                                            -     -     -         


    ECgene alternative splicing isoforms for AKAP7

    Expression
    for AKAP7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AKAP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTCTTAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See AKAP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AKAP7

    SOURCE GeneReport for Unigene cluster: Hs.486483

    UniProtKB/Swiss-Prot: AKA7A_HUMAN, O43687
    Tissue specificity: Expressed in brain, heart, lung, pancreas and skeletal muscle

    UniProtKB/Swiss-Prot: AKA7G_HUMAN, Q9P0M2
    Tissue specificity: Expressed in brain, heart, lung, pancreas and placenta

        SABiosciences Custom PCR Arrays for AKAP7
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    In Situ
    Assay Products:     
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    Orthologs
    for AKAP7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for AKAP7 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Akap71 , 5 A kinase (PRKA) anchor protein 71, 5 81.78(n)1
    79.74(a)1    		   10 (12.26 cM)5
    4324421  NM_018747.41  NP_061217.31 
     251690905 
    chicken
    (Gallus gallus)    		 Aves AKAP71 A kinase (PRKA) anchor protein 7 64.52(n)
    56.73(a)    		   426926  XM_424536.3  XP_424536.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 58(a)
    		 1 ↔ 1
    		 1(203962075-204016972)
    zebrafish
    (Danio rerio)    		 Actinopterygii akap76
    		 A kinase (PRKA) anchor protein 7
    		 32(a)
    		 1 ↔ 1
    		 20(2448526-2510462)


    ENSEMBL Gene Tree for AKAP7 (if available)
    TreeFam Gene Tree for AKAP7 (if available) 

    Paralogs
    for AKAP7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for AKAP7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2398 NCBI SNPs in AKAP7 are shown (see all 2398)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs787013791,2
    		F,--129036241(+) AACGAT/CGATAA 1 -- us2k11Minor allele frequency- C:0.07WA 118
    rs77503511,2
    		C,--129036388(+) gttgtT/Ctgttt 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs48975031,2
    		C,A,H,--129036655(+) ttgggG/Tttaca 1 -- us2k13Minor allele frequency- T:0.16NA WA 240
    rs792125171,2
    		F,--129036790(+) TTAGTT/ATCTGA 1 -- us2k11Minor allele frequency- A:0.05NA 120
    rs283943621,2
    		--129037075(+) TGTTAG/TAATTA 1 -- us2k12Minor allele frequency- T:0.11CSA WA 119
    rs1173648541,2
    		C,F,--129037295(+) CAATAG/ACATTC 1 -- us2k11Minor allele frequency- A:0.05NA 120
    rs1150495511,2
    		C,F,--129037711(+) GAGGCC/TGCGGG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs766535761,2
    		--129037925(+) GCTGCC/TGCGGC 1 -- us2k12Minor allele frequency- T:0.33NA CSA 3
    rs1125234341,2
    		C,--129038134(+) CCGCCG/ACTGCC 1 -- ut511Minor allele frequency- A:0.50WA 2
    rs770950041,2
    		F,--129038569(+) AATTTC/GGATTT 1 -- int11Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for AKAP7 (131456806 - 131604675 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for AKAP7
         1 CNV: 4508

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    Disorders / Diseases
    for AKAP7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AKAP7 for disorders           About GeneDecksing

    OMIM gene information: 604693    OMIM disorders: --

    2 diseases for AKAP7:    About MalaCards
    febrile seizures    seizures

    Human Genome Epidemiology (HuGE) Navigator: AKAP7 (1 document)

    Export disorders for AKAP7 gene to outside databases

    Publications
    for AKAP7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AKAP7 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with AKAP7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Alternative splicing regulates the subcellular localization of A- kinase anchoring protein 18 isoforms. (PubMed id 10613906)1, 2, 9 Trotter K.W....Milgram S.L. (1999)
    2. The A-kinase anchoring protein 15 regulates feedback inhibition of the epithelial Na+ channel. (PubMed id 17244820)1, 2 Bengrine A....Awayda M.S. (2007)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. A novel lipid-anchored A-kinase anchoring protein facilitates cAMP- responsive membrane events. (PubMed id 9545239)1, 3 Fraser I.D.C.... Scott J.D. (1998)
    5. Spatiotemporal regulation of PKC via interactions with AKAP7 isoforms. (PubMed id 22670899)1 Redden J.M....Dodge-Kafka K.L. (2012)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    8. AKAP18 contains a phosphoesterase domain that binds AMP. (PubMed id 18082768)1 Gold M.G....Barford D. (2008)
    9. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    External Searches for AKAP7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing AKAP7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9465 HGNC: 377 AceView: AKAP7 Ensembl:ENSG00000118507 euGenes: HUgn9465
    ECgene: AKAP7 H-InvDB: AKAP7

    Other Databases showing AKAP7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AKAP7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AKAP7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AKAP7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AKAP7 gene:
    Search GeneIP for patents involving AKAP7

    GeneCards and IP:
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