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Aliases for AKAP7 Gene

Aliases for AKAP7 Gene

  • A-Kinase Anchoring Protein 7 2 3 5
  • A Kinase (PRKA) Anchor Protein 7 2 3
  • A-Kinase Anchor Protein 18 KDa 3 4
  • AKAP-7 Isoforms Alpha And Beta 3 4
  • PRKA7 Isoforms Alpha/Beta 3 4
  • AKAP-7 Isoform Gamma 3 4
  • PRKA7 Isoform Gamma 3 4
  • AKAP 18 3 4
  • AKAP15 3 4
  • AKAP18 3 4
  • Protein Kinase A-Anchoring Protein 7 Isoforms Alpha/Beta 4
  • Protein Kinase A-Anchoring Protein 7 Isoform Gamma 4
  • A-Kinase Anchor Protein 7 Isoforms Alpha And Beta 3
  • A-Kinase Anchor Protein 9 KDa 3

External Ids for AKAP7 Gene

Previous GeneCards Identifiers for AKAP7 Gene

  • GC06P131313
  • GC06P131447
  • GC06P131508
  • GC06P129047

Summaries for AKAP7 Gene

Entrez Gene Summary for AKAP7 Gene

  • This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Apr 2011]

GeneCards Summary for AKAP7 Gene

AKAP7 (A-Kinase Anchoring Protein 7) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and G Protein Signaling Pathways. GO annotations related to this gene include nucleotide binding and protein kinase A binding.

UniProtKB/Swiss-Prot for AKAP7 Gene

  • Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.

  • Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.

Gene Wiki entry for AKAP7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP7 Gene

Genomics for AKAP7 Gene

Regulatory Elements for AKAP7 Gene

Enhancers for AKAP7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AKAP7 on UCSC Golden Path with GeneCards custom track

Promoters for AKAP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AKAP7 on UCSC Golden Path with GeneCards custom track

Genomic Location for AKAP7 Gene

Chromosome:
6
Start:
131,135,666 bp from pter
End:
131,283,535 bp from pter
Size:
147,870 bases
Orientation:
Plus strand

Genomic View for AKAP7 Gene

Genes around AKAP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP7 Gene

Proteins for AKAP7 Gene

  • Protein details for AKAP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43687-AKA7A_HUMAN
    Recommended name:
    A-kinase anchor protein 7 isoforms alpha and beta
    Protein Accession:
    O43687
    Secondary Accessions:
    • A8K2K6
    • Q5TBR9
    • Q5TBS0
    • Q9HCZ8
    • Q9P0G4

    Protein attributes for AKAP7 Gene

    Size:
    104 amino acids
    Molecular mass:
    11465 Da
    Quaternary structure:
    • Binds cAMP-dependent protein kinase (PKA). Interacts with PRKCA; only the cytoplasmic form is capable of interacting with PRKCA.

    Alternative splice isoforms for AKAP7 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for AKAP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0M2-AKA7G_HUMAN
    Recommended name:
    A-kinase anchor protein 7 isoform gamma
    Protein Accession:
    Q9P0M2
    Secondary Accessions:
    • B4DUC3
    • Q9HCZ8

    Protein attributes for AKAP7 Gene

    Size:
    348 amino acids
    Molecular mass:
    39518 Da
    Quaternary structure:
    • Binds cAMP-dependent protein kinase (PKA). Interacts with PRKCA; only the cytoplasmic form is capable of interacting with PRKCA.
    SequenceCaution:
    • Sequence=AAF28106.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI19003.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19788.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21509.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for AKAP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKAP7 Gene

Proteomics data for AKAP7 Gene at MOPED

Post-translational modifications for AKAP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AKAP7 Gene

Domains & Families for AKAP7 Gene

Gene Families for AKAP7 Gene

Protein Domains for AKAP7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AKAP7: view

No data available for UniProtKB/Swiss-Prot for AKAP7 Gene

Function for AKAP7 Gene

Molecular function for AKAP7 Gene

GENATLAS Biochemistry:
A kinase (PRKA regulatory subunit RIIA) anchor protein 7,potentially involved in ion channel activation
UniProtKB/Swiss-Prot Function:
Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.
UniProtKB/Swiss-Prot Function:
Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.

Gene Ontology (GO) - Molecular Function for AKAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IEA --
GO:0034237 protein kinase A regulatory subunit binding IEA --
genes like me logo Genes that share ontologies with AKAP7: view
genes like me logo Genes that share phenotypes with AKAP7: view

Animal Models for AKAP7 Gene

MGI Knock Outs for AKAP7:

Animal Model Products

miRNA for AKAP7 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AKAP7 Gene

Localization for AKAP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP7 Gene

Isoform Alpha: Lateral cell membrane; Lipid-anchor. Note=Targeted predominantly to the lateral membrane.
Isoform Beta: Apical cell membrane; Lipid-anchor. Note=Targeted predominantly to the apical membrane.
Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP7 Gene COMPARTMENTS Subcellular localization image for AKAP7 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
cytoskeleton 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for AKAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 10613906
GO:0016328 lateral plasma membrane IDA 10613906
genes like me logo Genes that share ontologies with AKAP7: view

Pathways & Interactions for AKAP7 Gene

genes like me logo Genes that share pathways with AKAP7: view

Pathways by source for AKAP7 Gene

1 BioSystems pathway for AKAP7 Gene
1 GeneGo (Thomson Reuters) pathway for AKAP7 Gene

Gene Ontology (GO) - Biological Process for AKAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001508 action potential IC 11299204
GO:0006811 ion transport TAS 9545239
GO:0008104 protein localization IC 9545239
GO:0035556 intracellular signal transduction TAS 10613906
GO:1901381 positive regulation of potassium ion transmembrane transport IDA 11299204
genes like me logo Genes that share ontologies with AKAP7: view

No data available for SIGNOR curated interactions for AKAP7 Gene

Drugs & Compounds for AKAP7 Gene

(2) Drugs for AKAP7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
calcium Nutra 0
genes like me logo Genes that share compounds with AKAP7: view

Transcripts for AKAP7 Gene

Unigene Clusters for AKAP7 Gene

A kinase (PRKA) anchor protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8
SP1:
SP2:
SP3: -
SP4: - - -

Relevant External Links for AKAP7 Gene

GeneLoc Exon Structure for
AKAP7
ECgene alternative splicing isoforms for
AKAP7

Expression for AKAP7 Gene

mRNA expression in normal human tissues for AKAP7 Gene

mRNA differential expression in normal tissues according to GTEx for AKAP7 Gene

This gene is overexpressed in Adrenal Gland (x5.5) and Pancreas (x4.3).

Protein differential expression in normal tissues from HIPED for AKAP7 Gene

This gene is overexpressed in Fetal Brain (33.7), Pancreas (11.1), and Adrenal (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AKAP7 Gene



SOURCE GeneReport for Unigene cluster for AKAP7 Gene Hs.486483

mRNA Expression by UniProt/SwissProt for AKAP7 Gene

O43687-AKA7A_HUMAN
Tissue specificity: Expressed in brain, heart, lung, pancreas and skeletal muscle.
genes like me logo Genes that share expression patterns with AKAP7: view

Protein tissue co-expression partners for AKAP7 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for AKAP7 Gene

Orthologs for AKAP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP7 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia AKAP7 35
  • 84.57 (n)
  • 79.94 (a)
AKAP7 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akap7 35
  • 81.78 (n)
  • 79.74 (a)
Akap7 16
Akap7 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AKAP7 35
  • 99.33 (n)
  • 99.14 (a)
AKAP7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akap7 35
  • 79.98 (n)
  • 75.29 (a)
cow
(Bos Taurus)
Mammalia AKAP7 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AKAP7 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKAP7 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves AKAP7 35
  • 65.83 (n)
  • 58.99 (a)
AKAP7 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKAP7 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia akap7 35
  • 55.47 (n)
  • 42.47 (a)
zebrafish
(Danio rerio)
Actinopterygii akap7 36
  • 32 (a)
OneToOne
Species with no ortholog for AKAP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKAP7 Gene

ENSEMBL:
Gene Tree for AKAP7 (if available)
TreeFam:
Gene Tree for AKAP7 (if available)

Paralogs for AKAP7 Gene

(1) SIMAP similar genes for AKAP7 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with AKAP7: view

No data available for Paralogs for AKAP7 Gene

Variants for AKAP7 Gene

Sequence variations from dbSNP and Humsavar for AKAP7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs7771473 - 131,145,341(+) CAGAG(A/G)AATTT nc-transcript-variant, reference, missense
rs1190788 - 131,199,515(-) TAAAA(C/T)TTCTG intron-variant, nc-transcript-variant, reference, missense
rs1190789 -- 131,199,367(-) ACTAA(C/T)TATTT intron-variant
rs1190790 -- 131,199,149(-) AACAT(C/T)CCAGT intron-variant
rs1190791 -- 131,198,984(-) AAGGT(C/G)TTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKAP7 Gene

Variant ID Type Subtype PubMed ID
nsv830807 CNV Loss 17160897
nsv886664 CNV Gain 21882294
nsv507362 CNV Insertion 20534489
nsv886665 CNV Gain 21882294
nsv830808 CNV Loss 17160897
nsv886666 CNV Gain 21882294

Variation tolerance for AKAP7 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.40; 88.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AKAP7 Gene

Disorders for AKAP7 Gene

Relevant External Links for AKAP7

Genetic Association Database (GAD)
AKAP7
Human Genome Epidemiology (HuGE) Navigator
AKAP7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKAP7

No disorders were found for AKAP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKAP7 Gene

Publications for AKAP7 Gene

  1. Alternative splicing regulates the subcellular localization of A- kinase anchoring protein 18 isoforms. (PMID: 10613906) Trotter K.W. … Milgram S.L. (J. Cell Biol. 1999) 3 4 23 67
  2. A novel lipid-anchored A-kinase anchoring protein facilitates cAMP- responsive membrane events. (PMID: 9545239) Fraser I.D.C. … Scott J.D. (EMBO J. 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Scaffold state switching amplifies, accelerates, and insulates protein kinase C signaling. (PMID: 24302730) Greenwald E.C. … Saucerman J.J. (J. Biol. Chem. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for AKAP7 Gene

Sources for AKAP7 Gene

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