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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AKAP6 Gene

protein-coding   GIFtS: 59
GCID: GC14P032798

A kinase (PRKA) anchor protein 6
 Explore 4 diseases affiliated with
AKAP6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AKAP6    

Aliases
for AKAP6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
A Kinase (PRKA) Anchor Protein 61 2     AKAP-62 3
AKAP1001 2 3     A-Kinase Anchor Protein 100 KDa2 3
PRKA61 2 3     AKAP 1002 3
MAKAP1     ADAP1002 5
ADAP61 2 5     A-Kinase Anchor Protein 62
KIAA03111 3     Protein Kinase A Anchoring Protein 62
Protein Kinase A-Anchoring Protein 62 3     

External Ids:    HGNC: 3761   Entrez Gene: 94722   Ensembl: ENSG000001513207   OMIM: 6046915   UniProtKB: Q130233   

Export aliases for AKAP6 gene to outside databases

Previous GC identifers: GC14P030175 GC14P026585 GC14P030788 GC14P031868 GC14P012916


Summaries
for AKAP6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AKAP6:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of
binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within
the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain
regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear
membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: AKAP6_HUMAN, Q13023
Function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or
sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes

Gene Wiki entry for AKAP6


Genomic Views
for AKAP6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AKAP6 gene promoter:
         MZF-1   SRY   POU2F1   AML1a   POU2F1a   IRF-7A   Pax-4a   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AKAP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for AKAP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKAP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q12   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q12

AKAP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKAP6 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P032798:  view genomic region     (about GC identifiers)

Start:
 32,798,479 bp from pter      End:
 33,302,268 bp from pter
Size:
 503,790 bases      Orientation:
 plus strand

Proteins
for AKAP6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AKAP6_HUMAN, Q13023 (See protein sequence)
Recommended Name: A-kinase anchor protein 6  
Size: 2319 amino acids; 256720 Da
Subunit: Interacts with RII subunit of PKA, phosphatase 2B (calcineurin) and AKAP79
Subcellular location: Sarcoplasmic reticulum. Nucleus membrane. Note=In heart muscle. Participation of multiple
targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic
amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences
Sequence caution: Sequence=BAA20770.2; Type=Erroneous initiation;
Secondary accessions: A7E2D4 O15028

Explore the universe of human proteins at neXtProt for AKAP6: NX_Q13023

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13023

    • AKAP6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004265.3  
    ENSEMBL proteins: 
     ENSP00000280979   ENSP00000450531   ENSP00000451146   ENSP00000451247   ENSP00000451239  
     ENSP00000451246   ENSP00000452204   ENSP00000452109  

    Human Recombinant Protein Products: 
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    Novus Biologicals AKAP6 Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for AKAP6

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005635nuclear envelope IDA10413680
    GO:0005640nuclear outer membrane ----
    GO:0005737cytoplasm ----
    GO:0016529sarcoplasmic reticulum IDA10830164


    AKAP6 for ontologies           About GeneDecksing



    AKAP6 Antibody Products: 
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    Uscn Antibodies for AKAP6
    Search ThermoFisher Antibodies for AKAP6

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    Uscn ELISAs and CLIAs for AKAP6

    Protein Domains /
    Families
    for AKAP6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AKAP6 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR026696 AKAP6/CEP68
     IPR002017 Spectrin_repeat
     IPR018159 Spectrin/alpha-actinin

    Graphical View of Domain Structure for InterPro Entry Q13023

    ProtoNet protein and cluster: Q13023

    1 Blocks protein family: IPB002017 Spectrin repeat

    UniProtKB/Swiss-Prot: AKAP6_HUMAN, Q13023
    Domain: RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein
    interactions with a complementary surface on the R-subunit dimer
    Similarity: Contains 2 spectrin repeats


    Function
    for AKAP6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AKAP6_HUMAN, Q13023
    Function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or
    sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes

         Genatlas biochemistry entry for AKAP6:
    A kinase (PRKA regulatory subunit RIIA),anchor protein 6,predominantly expressed in skeletal and cardiac
    muscle,localized in the sarcoplasmic reticulum

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKAP6
    8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate AKAP6 (see all 91):
    hsa-miR-607 hsa-miR-300 hsa-miR-4305 hsa-miR-219-5p hsa-miR-374a hsa-miR-578 hsa-miR-138-2* hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmid: AKAP6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKAP6 (see all 7)
    OriGene shRNA RFP: AKAP6
    OriGene siRNA: AKAP6
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKAP6 

    Cell Line
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    Search LifeMap BioReagents cell lines for AKAP6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP6

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI10830164
    GO:0005515protein binding IPI17923693
    GO:0019899enzyme binding ----
    GO:0032947protein complex scaffold ----
    GO:0034237protein kinase A regulatory subunit binding ----


    AKAP6 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Akap6tm1Jsco for AKAP6
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Akap6):
     craniofacial  growth/size  mortality/aging 

    AKAP6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for AKAP6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		Activation of PKA through GPCR0.71
    		cAMP Pathway0.77
    		PKA Signaling0.56
    2Signal transduction Calcium signaling
    		Signal transduction Calcium signaling1.00
    		Signal transduction_Calcium signaling0.97
    3PKA activation in glucagon signalling
    		Development Beta-adrenergic receptors signaling via cAMP0.29
    		Development_Beta-adrenergic receptors signaling via cAMP0.29
    4G Protein Signaling Pathways
    		G Protein Signaling Pathways1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for AKAP6
        Signal transduction Calcium signaling
    Development Beta-adrenergic receptors signaling via cAMP

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AKAP6
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    2 GeneGo (Thomson Reuters) Pathways for AKAP6
        Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction Calcium signaling

    1 BioSystems Pathway for AKAP6 
        G Protein Signaling Pathways



    AKAP6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AKAP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for AKAP6 (Q130231, 2, 3 ENSP000002809794) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110021 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8110911 I2D: score=3 STRING: ENSP00000357656
    PIK3R1P279862, 3, ENSP000002743354MINT-8111679 I2D: score=3 STRING: ENSP00000274335
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006605protein targeting NAS10413680
    GO:0010738regulation of protein kinase A signaling cascade ----
    GO:0032514positive regulation of protein phosphatase type 2B activity ----


    AKAP6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AKAP6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AKAP6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AKAP6
    2 Novoseek chemical compound relationships for AKAP6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ryanodine 68.4 9 11590243 (4), 12709444 (2), 15652351 (1)
    calcium 18.9 6 12709444 (3), 15652351 (1), 11590243 (1)

    Search CenterWatch for drugs/clinical trials and news about AKAP6 

    Transcripts
    for AKAP6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AKAP6 gene: 
    NM_004274.4  

    Unigene Cluster for AKAP6:

    A kinase (PRKA) anchor protein 6
    Hs.509083  [show with all ESTs]
    Unigene Representative Sequence: NM_004274
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280979(uc001wrq.3) ENST00000557354(uc010aml.3) ENST00000557102
    ENST00000556037 ENST00000557272 ENST00000554449 ENST00000553547 ENST00000554410
    ENST00000556638 ENST00000555207 ENST00000555950 ENST00000557396 ENST00000557708
    ENST00000556540 ENST00000554740

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKAP6
    8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate AKAP6 (see all 91):
    hsa-miR-607 hsa-miR-300 hsa-miR-4305 hsa-miR-219-5p hsa-miR-374a hsa-miR-578 hsa-miR-138-2* hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmid: AKAP6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKAP6 (see all 7)
    OriGene shRNA RFP: AKAP6
    OriGene siRNA: AKAP6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKAP6
    Clone
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    GenScript: all cDNA clones in your preferred vector: AKAP6 (NM_004274)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKAP6 
    Primer
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    Additional cDNA sequence: 

    AB002309.2 AK094160.1 BC137232.1 BC137233.1 BC150185.1 BC150288.1 BC154413.1 U17195.2 

    8 DOTS entries:

    DT.214046  DT.91746795  DT.100708112  DT.91980815  DT.120757720  DT.40254353  DT.91746793  DT.87013022 

    24/81 AceView cDNA sequences (see all 81):

    BX490998 U17195 BQ716719 BX646968 N39150 AB002309 AA906603 BF438380 
    NM_004274 CA393755 CD300341 BU145681 BM929875 BM684310 BQ896848 AL118892 
    BQ876416 BP349684 AL118891 AI016287 C05186 N52787 CF551802 BG189152 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for AKAP6    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                    -     -           -     -                                                                                 
    SP2:                    -     -           -                                                                                       
    SP3:                          -                                                                                                   
    SP4:                                      -     -                                                                                 
    SP5:                    -     -                                                                                                   


    ECgene alternative splicing isoforms for AKAP6

    Expression
    for AKAP6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AKAP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAAAAATTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AKAP6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    BrainMeningesBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See AKAP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AKAP6

    SOURCE GeneReport for Unigene cluster: Hs.509083

    UniProtKB/Swiss-Prot: AKAP6_HUMAN, Q13023
    Tissue specificity: Highly expressed in cardiac and skeletal muscle, followed by brain

        SABiosciences Custom PCR Arrays for AKAP6
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    In Situ
    Assay Products:     
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    Orthologs
    for AKAP6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for AKAP6 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Akap61 , 5 A kinase (PRKA) anchor protein 61, 5 83.13(n)1
    81.49(a)1    		   12 (22.18 cM)5
    2381611  NM_198111.21  NP_932779.21 
     526993835 
    chicken
    (Gallus gallus)    		 Aves AKAP61 A kinase (PRKA) anchor protein 6 72.11(n)
    68.15(a)    		   423314  XM_003641359.1  XP_003641407.1 
    lizard
    (Anolis carolinensis)    		 Reptilia AKAP66
    		 --
    		 60(a)
    		 1 ↔ 1
    		 2(56035457-56296838)
    zebrafish
    (Danio rerio)    		 Actinopterygii akap61 A kinase (PRKA) anchor protein 6 55.34(n)
    51.01(a)    		   100002625  XM_001919913.3  XP_001919948.2 


    ENSEMBL Gene Tree for AKAP6 (if available)
    TreeFam Gene Tree for AKAP6 (if available) 

    Paralogs
    for AKAP6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for AKAP6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9396 NCBI SNPs in AKAP6 are shown (see all 9396)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2021251191,2
    		C--13027130(-) CTTTTA/TANNNN 1 -- int10--------
    rs1832852151,2
    		--32796530(+) CCTGTC/GCTCTC 1 -- us2k10--------
    rs1874523611,2
    		--32796542(+) TCTTTA/GTAGCA 1 -- us2k10--------
    rs101331841,2
    		C,F,A,H,--32796591(+) AATAGG/ATCCAT 1 -- us2k127Minor allele frequency- A:0.12NA NS EA WA CSA 2688
    rs1910808091,2
    		--32796595(+) GGTCCA/GTGTCT 1 -- us2k10--------
    rs1114732211,2
    		C,--32796596(+) GTCCAC/TGTCTC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1837222641,2
    		--32796765(+) ATTAAA/GAGAAA 1 -- us2k10--------
    rs1455231911,2
    		--32796801(+) AAAACC/TATGGT 1 -- us2k10--------
    rs1876516171,2
    		--32796878(+) TGATAA/TCACAC 1 -- us2k10--------
    rs1382371551,2
    		--32796931(+) ACTCTC/GAGATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AKAP6 (32798479 - 33048479 bp, first 250kb of AKAP6)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for AKAP6
         2 CNVs: 3933 101915
         5 Indels: 76614 33584 71880 87164 76613

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    Disorders / Diseases
    for AKAP6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AKAP6 for disorders           About GeneDecksing

    OMIM gene information: 604691    OMIM disorders: --

    4 diseases for AKAP6:    About MalaCards
    anorexia nervosa    polycystic kidney disease    kidney disease    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for AKAP6:
    Focal epilepsy
    Human Genome Epidemiology (HuGE) Navigator: AKAP6 (2 documents)

    Export disorders for AKAP6 gene to outside databases

    Publications
    for AKAP6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AKAP6 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with AKAP6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of A-kinase anchor protein 100 (AKAP100). A protein that targets A-kinase to the sarcoplasmic reticulum. (PubMed id 7721854)1, 2, 3, 9 McCartney S.... Scott J.D. (1995)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
    3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    4. mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes. (PubMed id 10413680)1, 2 Kapiloff M.S.... Scott J.D. (1999)
    5. cAMP-stimulated protein phosphatase 2A activity assoc iated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibi ts the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4 D3. (PubMed id 20106966)1, 9 Dodge-Kafka K.L....Kapiloff M.S. (2010)
    6. mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module. (PubMed id 11296225)1, 9 Dodge K.L....Scott J.D. (2001)
    7. Sodium/calcium exchanger (NCX1) macromolecular complex. (PubMed id 12754202)1, 9 Schulze D.H....Ruknudin A.M. (2003)
    8. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. (PubMed id 10830164)1, 9 Marx S.O....Marks A.R. (2000)
    9. The genetic architecture of economic and political pre ferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (2012)
    10. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resi stance. (PubMed id 22581228)1 Manning A.K....Langenberg C. (2012)

    External Searches for AKAP6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing AKAP6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9472 HGNC: 376 AceView: AKAP6 Ensembl:ENSG00000151320 euGenes: HUgn9472
    ECgene: AKAP6 H-InvDB: AKAP6

    Other Databases showing AKAP6 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0311

    Specialized Databases showing AKAP6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AKAP6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AKAP6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AKAP6 gene:
    Search GeneIP for patents involving AKAP6

    GeneCards and IP:
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