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Aliases for AKAP5 Gene

Aliases for AKAP5 Gene

  • A Kinase (PRKA) Anchor Protein 5 2 3
  • CAMP-Dependent Protein Kinase Regulatory Subunit II High Affinity-Binding Protein 3 4
  • A-Kinase Anchor Protein 79 KDa 3 4
  • AKAP 79 3 4
  • AKAP79 3 4
  • H21 3 4
  • A-Kinase Anchoring Protein 75/79 3
  • A-Kinase Anchor Protein 5 3
  • AKAP75 3
  • AKAP-5 4

External Ids for AKAP5 Gene

Summaries for AKAP5 Gene

Entrez Gene Summary for AKAP5 Gene

  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKAP5 Gene

AKAP5 (A Kinase (PRKA) Anchor Protein 5) is a Protein Coding gene. Diseases associated with AKAP5 include ureterolithiasis and canavan disease. Among its related pathways are GPCR Pathway and Activation of cAMP-Dependent PKA. GO annotations related to this gene include calmodulin binding and adenylate cyclase binding.

UniProtKB/Swiss-Prot for AKAP5 Gene

  • May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade

Gene Wiki entry for AKAP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP5 Gene

Genomics for AKAP5 Gene

Genomic Location for AKAP5 Gene

64,465,499 bp from pter
64,474,503 bp from pter
9,005 bases
Plus strand

Genomic View for AKAP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP5 Gene

Regulatory Elements for AKAP5 Gene

Proteins for AKAP5 Gene

  • Protein details for AKAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A-kinase anchor protein 5
    Protein Accession:
    Secondary Accessions:
    • A2RRB8

    Protein attributes for AKAP5 Gene

    427 amino acids
    Molecular mass:
    47088 Da
    Quaternary structure:
    • Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 AND PDE4C (By similarity). Interacts with ADCY8, and enhances its phosphorylation at lipid rafts.

    Three dimensional structures from OCA and Proteopedia for AKAP5 Gene

neXtProt entry for AKAP5 Gene

Proteomics data for AKAP5 Gene at MOPED

Post-translational modifications for AKAP5 Gene

  • Palmitoylation at Cys-36 and Cys-129 plays a key role in targeting to lipid rafts.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKAP5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for AKAP5 Gene

Domains for AKAP5 Gene

Gene Families for AKAP5 Gene

  • AKAP :A-kinase anchor proteins

Protein Domains for AKAP5 Gene


  • RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer:
    • P24588
  • The N-terminal region, which is highly basic, is required for interaction with calmodulin:
    • P24588
  • Contains 1 AKAP domain.:
    • P24588
genes like me logo Genes that share domains with AKAP5: view

Function for AKAP5 Gene

Molecular function for AKAP5 Gene

GENATLAS Biochemistry: A kinase (PRKA regulatory subunits RIA,RIIA,PKC) anchor protein 5
UniProtKB/Swiss-Prot Function: May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade

Gene Ontology (GO) - Molecular Function for AKAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11287423
GO:0005516 calmodulin binding IEA --
GO:0008179 adenylate cyclase binding IPI 17081159
GO:0051018 protein kinase A binding TAS 1512224
genes like me logo Genes that share ontologies with AKAP5: view
genes like me logo Genes that share phenotypes with AKAP5: view

Animal Models for AKAP5 Gene

MGI Knock Outs for AKAP5:

miRNA for AKAP5 Gene

miRTarBase miRNAs that target AKAP5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AKAP5 Gene

Localization for AKAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP5 Gene

Membrane; Lipid-anchor. Note=Associates with lipid rafts.

Subcellular locations from

Jensen Localization Image for AKAP5 Gene COMPARTMENTS Subcellular localization image for AKAP5 gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 3

Gene Ontology (GO) - Cellular Components for AKAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with AKAP5: view

Pathways for AKAP5 Gene

genes like me logo Genes that share pathways with AKAP5: view

Gene Ontology (GO) - Biological Process for AKAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006605 protein targeting IEA --
GO:0007165 signal transduction IEA --
GO:0007268 synaptic transmission TAS --
GO:0010739 positive regulation of protein kinase A signaling IMP 17081159
genes like me logo Genes that share ontologies with AKAP5: view

Compounds for AKAP5 Gene

(1) HMDB Compounds for AKAP5 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP

(10) Novoseek inferred chemical compound relationships for AKAP5 Gene

Compound -log(P) Hits PubMed IDs
guanylate 46.8 2
serine 24.8 2
threonine 18.4 1
calcium 13.6 8
tacrolimus 12.6 2
genes like me logo Genes that share compounds with AKAP5: view

Transcripts for AKAP5 Gene

mRNA/cDNA for AKAP5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AKAP5 Gene

A kinase (PRKA) anchor protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP5 Gene

No ASD Table

Relevant External Links for AKAP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AKAP5 Gene

mRNA expression in normal human tissues for AKAP5 Gene

mRNA differential expression in normal tissues according to GTEx for AKAP5 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKAP5 Gene

SOURCE GeneReport for Unigene cluster for AKAP5 Gene Hs.656683

mRNA Expression by UniProt/SwissProt for AKAP5 Gene

Tissue specificity: Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary
genes like me logo Genes that share expressions with AKAP5: view

Orthologs for AKAP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AKAP5 36
  • 99.69 (n)
  • 99.3 (a)
AKAP5 37
  • 99 (a)
(Bos Taurus)
Mammalia AKAP5 36
  • 85.92 (n)
  • 75.82 (a)
AKAP5 37
  • 76 (a)
(Canis familiaris)
Mammalia AKAP5 36
  • 86.23 (n)
  • 76.29 (a)
AKAP5 37
  • 76 (a)
(Mus musculus)
Mammalia Akap5 36
  • 74.1 (n)
  • 62.59 (a)
Akap5 16
Akap5 37
  • 35 (a)
(Monodelphis domestica)
Mammalia AKAP5 37
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia AKAP5 37
  • 45 (a)
(Rattus norvegicus)
Mammalia Akap5 36
  • 74.1 (n)
  • 60.33 (a)
(Gallus gallus)
Aves AKAP5 37
  • 32 (a)
(Anolis carolinensis)
Reptilia AKAP5 37
  • 29 (a)
Species with no ortholog for AKAP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AKAP5 Gene

Gene Tree for AKAP5 (if available)
Gene Tree for AKAP5 (if available)

Paralogs for AKAP5 Gene

No data available for Paralogs for AKAP5 Gene

Variants for AKAP5 Gene

Sequence variations from dbSNP and Humsavar for AKAP5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_056732 -
VAR_056733 -
VAR_060735 -

Structural Variations from Database of Genomic Variants (DGV) for AKAP5 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073
nsv902022 CNV Gain 21882294

Relevant External Links for AKAP5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for AKAP5 Gene

(2) University of Copenhagen DISEASES for AKAP5 Gene

genes like me logo Genes that share disorders with AKAP5: view

No data available for UniProtKB/Swiss-Prot for AKAP5 Gene

Publications for AKAP5 Gene

  1. Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79. (PMID: 1512224) Carr D.W. … Scott J.D. (J. Biol. Chem. 1992) 2 3 4 23
  2. Protein kinase A anchoring to the myometrial plasma membrane is required for cyclic adenosine 3',5'-monophosphate regulation of phosphatidylinositide turnover. (PMID: 10537145) Dodge K.L. … Sanborn B.M. (Endocrinology 1999) 3 23
  3. AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region. (PMID: 9765270) Kashishian A. … Lai Y. (J. Biol. Chem. 1998) 3 23
  4. Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton. (PMID: 8509414) Glantz S.B. … Rubin C.S. (J. Biol. Chem. 1993) 3 23
  5. Regulation of the AKAP79-protein kinase C interaction by Ca2+/Calmodulin. (PMID: 9202019) Faux M.C. … Scott J.D. (J. Biol. Chem. 1997) 3 23

Products for AKAP5 Gene

Sources for AKAP5 Gene

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