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Aliases for AKAP5 Gene

Aliases for AKAP5 Gene

  • A Kinase (PRKA) Anchor Protein 5 2 3
  • CAMP-Dependent Protein Kinase Regulatory Subunit II High Affinity-Binding Protein 3 4
  • A-Kinase Anchor Protein 79 KDa 3 4
  • AKAP 79 3 4
  • AKAP79 3 4
  • H21 3 4
  • A-Kinase Anchoring Protein 75/79 3
  • AKAP75 3
  • AKAP-5 4

External Ids for AKAP5 Gene

Previous GeneCards Identifiers for AKAP5 Gene

  • GC14P062262
  • GC14P058727
  • GC14P062923
  • GC14P064003
  • GC14P064932
  • GC14P045104

Summaries for AKAP5 Gene

Entrez Gene Summary for AKAP5 Gene

  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKAP5 Gene

AKAP5 (A Kinase (PRKA) Anchor Protein 5) is a Protein Coding gene. Diseases associated with AKAP5 include corneal ectasia and ureterolithiasis. Among its related pathways are GPCR Pathway and Activation of cAMP-Dependent PKA. GO annotations related to this gene include calmodulin binding and adenylate cyclase binding.

UniProtKB/Swiss-Prot for AKAP5 Gene

  • May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade

Gene Wiki entry for AKAP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP5 Gene

Genomics for AKAP5 Gene

Regulatory Elements for AKAP5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AKAP5 Gene

Chromosome:
14
Start:
64,465,499 bp from pter
End:
64,474,503 bp from pter
Size:
9,005 bases
Orientation:
Plus strand

Genomic View for AKAP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP5 Gene

Proteins for AKAP5 Gene

  • Protein details for AKAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24588-AKAP5_HUMAN
    Recommended name:
    A-kinase anchor protein 5
    Protein Accession:
    P24588
    Secondary Accessions:
    • A2RRB8

    Protein attributes for AKAP5 Gene

    Size:
    427 amino acids
    Molecular mass:
    47088 Da
    Quaternary structure:
    • Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 AND PDE4C (By similarity). Interacts with ADCY8, and enhances its phosphorylation at lipid rafts.

    Three dimensional structures from OCA and Proteopedia for AKAP5 Gene

neXtProt entry for AKAP5 Gene

Proteomics data for AKAP5 Gene at MOPED

Post-translational modifications for AKAP5 Gene

  • Palmitoylation at Cys-36 and Cys-129 plays a key role in targeting to lipid rafts.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKAP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AKAP5 (AKAP5)

No data available for DME Specific Peptides for AKAP5 Gene

Domains & Families for AKAP5 Gene

Gene Families for AKAP5 Gene

Protein Domains for AKAP5 Gene

Graphical View of Domain Structure for InterPro Entry

P24588

UniProtKB/Swiss-Prot:

AKAP5_HUMAN :
  • RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer
Domain:
  • RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer
  • The N-terminal region, which is highly basic, is required for interaction with calmodulin
  • Contains 1 AKAP domain.
genes like me logo Genes that share domains with AKAP5: view

Function for AKAP5 Gene

Molecular function for AKAP5 Gene

GENATLAS Biochemistry:
A kinase (PRKA regulatory subunits RIA,RIIA,PKC) anchor protein 5
UniProtKB/Swiss-Prot Function:
May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade

Gene Ontology (GO) - Molecular Function for AKAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IEA --
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 11287423
GO:0005516 calmodulin binding IEA --
GO:0008179 adenylate cyclase binding IPI 17081159
genes like me logo Genes that share ontologies with AKAP5: view
genes like me logo Genes that share phenotypes with AKAP5: view

Animal Models for AKAP5 Gene

MGI Knock Outs for AKAP5:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKAP5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for AKAP5 Gene

Localization for AKAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP5 Gene

Membrane; Lipid-anchor. Note=Associates with lipid rafts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP5 Gene COMPARTMENTS Subcellular localization image for AKAP5 gene
Compartment Confidence
cytosol 4
plasma membrane 4
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for AKAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane TAS --
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with AKAP5: view

Pathways & Interactions for AKAP5 Gene

genes like me logo Genes that share pathways with AKAP5: view

Gene Ontology (GO) - Biological Process for AKAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0006112 energy reserve metabolic process TAS --
GO:0006605 protein targeting IEA --
GO:0007165 signal transduction IEA --
GO:0007194 negative regulation of adenylate cyclase activity IEA --
genes like me logo Genes that share ontologies with AKAP5: view

No data available for SIGNOR curated interactions for AKAP5 Gene

Drugs & Compounds for AKAP5 Gene

(9) Drugs for AKAP5 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tacrolimus Approved, Investigational Pharma 992
cyclic amp Experimental Pharma 0
Potassium Experimental Pharma 0
ATP Pharma Activator 0
NMDA Pharma Full agonist, Agonist 0

(2) Additional Compounds for AKAP5 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glutamate
guanylate
genes like me logo Genes that share compounds with AKAP5: view

Transcripts for AKAP5 Gene

mRNA/cDNA for AKAP5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AKAP5 Gene

A kinase (PRKA) anchor protein 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKAP5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP5 Gene

No ASD Table

Relevant External Links for AKAP5 Gene

GeneLoc Exon Structure for
AKAP5
ECgene alternative splicing isoforms for
AKAP5

Expression for AKAP5 Gene

mRNA expression in normal human tissues for AKAP5 Gene

mRNA differential expression in normal tissues according to GTEx for AKAP5 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.2).

Protein differential expression in normal tissues from HIPED for AKAP5 Gene

This gene is overexpressed in Frontal cortex (38.9) and Brain (29.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKAP5 Gene



SOURCE GeneReport for Unigene cluster for AKAP5 Gene Hs.656683

mRNA Expression by UniProt/SwissProt for AKAP5 Gene

P24588-AKAP5_HUMAN
Tissue specificity: Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary
genes like me logo Genes that share expression patterns with AKAP5: view

Protein tissue co-expression partners for AKAP5 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for AKAP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AKAP5 35
  • 85.92 (n)
  • 75.82 (a)
AKAP5 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKAP5 35
  • 86.23 (n)
  • 76.29 (a)
AKAP5 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akap5 35
  • 74.1 (n)
  • 62.59 (a)
Akap5 16
Akap5 36
  • 35 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AKAP5 35
  • 99.69 (n)
  • 99.3 (a)
AKAP5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akap5 35
  • 74.1 (n)
  • 60.33 (a)
oppossum
(Monodelphis domestica)
Mammalia AKAP5 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKAP5 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves AKAP5 36
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKAP5 36
  • 29 (a)
OneToOne
Species with no ortholog for AKAP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AKAP5 Gene

ENSEMBL:
Gene Tree for AKAP5 (if available)
TreeFam:
Gene Tree for AKAP5 (if available)

Paralogs for AKAP5 Gene

No data available for Paralogs for AKAP5 Gene

Variants for AKAP5 Gene

Sequence variations from dbSNP and Humsavar for AKAP5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_060735 -
VAR_056733 -
VAR_056732 -

Structural Variations from Database of Genomic Variants (DGV) for AKAP5 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073
nsv902022 CNV Gain 21882294

Variation tolerance for AKAP5 Gene

Residual Variation Intolerance Score: 65.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKAP5 Gene

HapMap Linkage Disequilibrium report
AKAP5
Human Gene Mutation Database (HGMD)
AKAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP5 Gene

Disorders for AKAP5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for AKAP5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
corneal ectasia
ureterolithiasis
  • ureteric stone
canavan disease
  • spongy degeneration of central nervous system
- elite association
Search AKAP5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AKAP5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKAP5
genes like me logo Genes that share disorders with AKAP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AKAP5 Gene

Publications for AKAP5 Gene

  1. Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79. (PMID: 1512224) Carr D.W. … Scott J.D. (J. Biol. Chem. 1992) 2 23 67
  2. Interaction with AKAP79 modifies the cellular pharmacology of PKC. (PMID: 20188672) Hoshi N. … Scott J.D. (Mol. Cell 2010) 23 67
  3. G-protein-coupled receptor-associated A-kinase anchoring proteins AKAP5 and AKAP12: differential trafficking and distribution. (PMID: 18950703) Chen M.H. … Malbon C.C. (Cell. Signal. 2009) 23 67
  4. A-kinase anchoring in dendritic cells is required for antigen presentation. (PMID: 19277197) Schillace R.V. … Carr D.W. (PLoS ONE 2009) 23 67
  5. Regulation of postsynaptic structure and function by an A-kinase anchoring protein-membrane-associated guanylate kinase scaffolding complex. (PMID: 19535604) Robertson H.R. … Dell'Acqua M.L. (J. Neurosci. 2009) 23 67

Products for AKAP5 Gene

Sources for AKAP5 Gene

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