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AKAP5 Gene

protein-coding   GIFtS: 59
GCID: GC14P064932

A Kinase (PRKA) Anchor Protein 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
A Kinase (PRKA) Anchor Protein 51 2     CAMP-Dependent Protein Kinase Regulatory Subunit II High Affinity-Binding
Protein2 3
AKAP792 3     AKAP752
H212 3     A-Kinase Anchor Protein 52
A-Kinase Anchor Protein 79 KDa2 3     A-Kinase Anchoring Protein 75/792
AKAP 792 3     AKAP-53

External Ids:    HGNC: 3751   Entrez Gene: 94952   Ensembl: ENSG000001798417   OMIM: 6046885   UniProtKB: P245883   

Export aliases for AKAP5 gene to outside databases

Previous GC identifers: GC14P062262 GC14P058727 GC14P062923 GC14P064003 GC14P045104


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AKAP5 Gene:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function
of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations
within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta
regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly
expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in
the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit
interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. (provided by RefSeq,
Jul 2008)

GeneCards Summary for AKAP5 Gene:
AKAP5 (A kinase (PRKA) anchor protein 5) is a protein-coding gene. Diseases associated with AKAP5 include frey syndrome, and ureterolithiasis. GO annotations related to this gene include calmodulin binding and adenylate cyclase binding.

UniProtKB/Swiss-Prot: AKAP5_HUMAN, P24588
Function: May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal
carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR)
not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR
signaling cascade

Gene Wiki entry for AKAP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the AKAP5 gene promoter:
         Nkx3-1   E2F-4   E2F-3a   E2F-5   Nkx3-1 v4   Nkx3-1 v1   E2F-2   AREB6   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAKAP5 promoter sequence
   Search Chromatin IP Primers for AKAP5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKAP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.3   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q23.3

AKAP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKAP5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P064932:  view genomic region     (about GC identifiers)

Start:
64,932,217 bp from pter      End:
64,941,221 bp from pter
Size:
9,005 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AKAP5_HUMAN, P24588 (See protein sequence)
Recommended Name: A-kinase anchor protein 5  
Size: 427 amino acids; 47088 Da
Subunit: Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and
also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound
to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5,
ADCY6 AND PDE4C (By similarity). Interacts with ADCY8, and enhances its phosphorylation at lipid rafts
2 PDB 3D structures from and Proteopedia for AKAP5:
2H9R (3D)        3LL8 (3D)    
Secondary accessions: A2RRB8

Explore the universe of human proteins at neXtProt for AKAP5: NX_P24588

Explore proteomics data for AKAP5 at MOPED

Post-translational modifications: 

  • Palmitoylation at Cys-36 and Cys-129 plays a key role in targeting to lipid rafts1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AKAP5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004848.3  
    ENSEMBL proteins: 
     ENSP00000378207   ENSP00000315615  
    Reactome Protein details: P24588

    AKAP5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AKAP: A-kinase anchor proteins

    1 InterPro protein domain:
     IPR001573 Pkinase-A_anch_WSK-motif

    Graphical View of Domain Structure for InterPro Entry P24588

    ProtoNet protein and cluster: P24588

    1 Blocks protein domain: IPB001573 Protein kinase A anchoring domain

    UniProtKB/Swiss-Prot: AKAP5_HUMAN, P24588
    Domain: RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein
    interactions with a complementary surface on the R-subunit dimer
    Domain: The N-terminal region, which is highly basic, is required for interaction with calmodulin
    Similarity: Contains 1 AKAP domain


    AKAP5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKAP5_HUMAN, P24588
    Function: May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal
    carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR)
    not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR
    signaling cascade

         Genatlas biochemistry entry for AKAP5:
    A kinase (PRKA regulatory subunits RIA,RIIA,PKC) anchor protein 5

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11287423
    GO:0005516calmodulin binding IEA--
    GO:0008179adenylate cyclase binding IPI17081159
    GO:0051018protein kinase A binding TAS1512224
         
    AKAP5 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Akap5):
     behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  nervous system 

    AKAP5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for AKAP5: Akap5tm1.1Jsco Akap5tm2Gsm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AKAP5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AKAP5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AKAP5

    miRNA
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    miRTarBase miRNAs that target AKAP5:
    hsa-mir-26b-5p (MIRT029184)

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    Selected qRT-PCR Assays for microRNAs that regulate AKAP5 (see all 65):
    hsa-miR-411* hsa-miR-607 hsa-miR-3607-3p hsa-miR-520e hsa-miR-411 hsa-miR-637 hsa-miR-520b hsa-miR-491-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat AKAP5

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AKAP5_HUMAN, P24588: Membrane; Lipid-anchor. Note=Associates with lipid rafts
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    AKAP5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AKAP5 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2Integration of energy metabolism
    Integration of energy metabolism0.75
    Regulation of Insulin Secretion by Glucagon-like Peptide-10.56
    Regulation of Insulin Secretion0.75
    3Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    4Trafficking of AMPA receptors
    Trafficking of AMPA receptors1.00
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity1.00
    5GPCR Pathway
    NFAT in Immune Response0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AKAP5 (see all 6)
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA
    NFAT and Cardiac Hypertrophy

    1 Cell Signaling Technology (CST) Pathway for AKAP5
        Ca, cAMP and Lipid Signaling

    3 BioSystems Pathways for AKAP5
        G Protein Signaling Pathways
    Calcium signaling in the CD4+ TCR pathway
    Role of Calcineurin-dependent NFAT signaling in lymphocytes


    2 Reactome Pathways for AKAP5
        Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
    Trafficking of AMPA receptors



    AKAP5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AKAP5
    Interactions:

        GeneGlobe Interaction Network for AKAP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AKAP5 (P245881, 2, 3 ENSP000003156154) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAR2AP138612, 3, ENSP000002655634MINT-2411902 I2D: score=3 STRING: ENSP00000265563
    RXFP1Q9HBX91, 2, 3, ENSP000003032484EBI-703640,EBI-8088969 MINT-8042760 MINT-8042779 MINT-8041863 MINT-8041836 I2D: score=1 STRING: ENSP00000303248
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006605protein targeting IEA--
    GO:0007165signal transduction IEA--
    GO:0007268synaptic transmission TAS--
    GO:0010739positive regulation of protein kinase A signaling IMP17081159

    AKAP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AKAP5

    1 HMDB Compound for AKAP5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    10 Novoseek inferred chemical compound relationships for AKAP5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanylate 46.8 2 17170109 (1), 12507994 (1)
    serine 24.8 2 15710486 (1), 19661060 (1)
    threonine 18.4 1 19661060 (1)
    calcium 13.6 11 15003529 (4), 12114507 (2), 11258666 (1), 11943807 (1)
    tacrolimus 12.6 4 11258666 (1), 15276470 (1)
    proline 11.4 1 8910553 (1)
    potassium 3.51 2 11287423 (2)
    atp 0 1 9707637 (1)
    glutamate 0 2 12724145 (1), 12507994 (1)
    nmda 0 1 12354762 (1)



    AKAP5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AKAP5 gene: 
    NM_004857.3  

    Unigene Cluster for AKAP5:

    A kinase (PRKA) anchor protein 5
    Hs.656683  [show with all ESTs]
    Unigene Representative Sequence: NM_004857
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394718(uc001xhd.4) ENST00000320636(uc021ruk.1)
    miRNA
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    hsa-miR-411* hsa-miR-607 hsa-miR-3607-3p hsa-miR-520e hsa-miR-411 hsa-miR-637 hsa-miR-520b hsa-miR-491-3p
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    Additional mRNA sequence: 

    AK124004.1 AK315336.1 BC057229.1 BC131516.1 M90359.1 

    3 DOTS entries:

    DT.409357  DT.402958  DT.91936593 

    21 AceView cDNA sequences:

    AW138111 Z43845 AW297698 NM_004857 Z39911 BX956107 N63107 AW768580 
    AI183310 AI222167 AW183685 BU101842 BC057229 AK124004 AA632151 BQ277446 
    R20145 BF338741 R44746 BU531824 R20144 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AKAP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AKAP5 Expression
    About this image


    AKAP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Pons
             Septum   
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
     
     Lung (Respiratory System)
    AKAP5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKAP5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656683

    UniProtKB/Swiss-Prot: AKAP5_HUMAN, P24588
    Tissue specificity: Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a
    lesser extent in adrenal medulla, lung and anterior pituitary

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AKAP5 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akap51 , 5 A kinase (PRKA) anchor protein 51, 5 74.1(n)1
    62.59(a)1
      12 (33.73 cM)5
    2382761  NM_001101471.11  NP_001094941.11 
     763248915 
    chicken
    (Gallus gallus)
    Aves AKAP56
    A kinase (PRKA) anchor protein 5
    32(a)
    1 ↔ 1
    5(52828565-52830355)
    lizard
    (Anolis carolinensis)
    Reptilia AKAP56
    A kinase (PRKA) anchor protein 5
    29(a)
    1 ↔ 1
    1(1442405-1443865)


    ENSEMBL Gene Tree for AKAP5 (if available)
    TreeFam Gene Tree for AKAP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AKAP5 (see all 171)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs748322981,2
    C,F--45102897(+) GATGAC/TTTGTT 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs752555001,2
    F--45102898(+) ATGACT/CTGTTT 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1459361731,2
    --64930311(+) CAAGAC/GCAGCC 1 -- us2k10--------
    rs1999755421,2
    C--64930345(+) AAAAA-/AGAAGA 1 -- us2k10--------
    rs2012295181,2
    --64930357(+) AAAAA-/AAAG  
            
    AAGAA
    1 -- us2k10--------
    rs1996798961,2
    --64930358(+) AAAAA-/AAGAAGAA 1 -- us2k10--------
    rs7456861,2
    C,F,A,H--64930632(+) CTTATA/GAGCAT 1 -- us2k125Minor allele frequency- G:0.36NS EA NA WA CSA 2536
    rs1845384211,2
    C--64930717(+) CATTTC/TGATAG 1 -- us2k10--------
    rs58092291,2
    C--64930754(+) CTGAA-/TTttttt 1 -- us2k1 trp30--------
    rs1178480351,2
    C,F--64930961(+) CCAGGC/TTGGTC 1 -- us2k11Minor allele frequency- T:0.02EA 120

    HapMap Linkage Disequilibrium report for AKAP5 (64932217 - 64941221 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AKAP5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748779CNV Deletion23290073
    nsv902022CNV Gain21882294

    Human Gene Mutation Database (HGMD): AKAP5
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing AKAP5
    DNA2.0 Custom Variant and Variant Library Synthesis for AKAP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604688    OMIM disorders: --

    10 diseases for AKAP5:    
    About MalaCards
    frey syndrome    ureterolithiasis    parotitis    canavan disease
    cerebritis    myasthenia gravis    alzheimer's disease    thyroiditis
    pancreatitis    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for AKAP5:
    Ureterolithiasis     Canavan disease

    AKAP5 for disorders           About GeneDecksing


    Export disorders for AKAP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AKAP5 gene, integrated from 10 sources (see all 103):
    (articles sorted by number of sources associating them with AKAP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79. (PubMed id 1512224)1, 2, 3, 9 Carr D.W.... Scott J.D. (J. Biol. Chem. 1992)
    2. Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8. (PubMed id 21771783)1, 2 Delint-Ramirez I....Cooper D.M. (J. Biol. Chem. 2011)
    3. Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. (PubMed id 1618839)1, 3 Carr D.W.... Scott J.D. (J. Biol. Chem. 1992)
    4. Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta. (PubMed id 1733921)1, 2 Hirsch A.H.... Rubin C.S. (J. Biol. Chem. 1992)
    5. AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region. (PubMed id 9765270)1, 9 Kashishian A....Lai Y. (J. Biol. Chem. 1998)
    6. Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1. (PubMed id 11287423)1, 9 Dart C. and Leyland M.L. (J. Biol. Chem. 2001)
    7. G-protein-coupled receptor-associated A-kinase anchoring proteins AKAP5 and AKAP12: differential trafficking and distribution. (PubMed id 18950703)1, 9 Chen M.H. and Malbon C.C. (Cell. Signal. 2009)
    8. AKAP79 selectively enhances protein kinase C regulation of GluR1 at a Ca2+-calmodulin-dependent protein kinase II/protein kinase C site. (PubMed id 18305116)1, 9 Tavalin S.J. (J. Biol. Chem. 2008)
    9. Imaging kinase--AKAP79--phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy. (PubMed id 12507994)1, 9 Oliveria S.F....Dell'Acqua M.L. (J. Cell Biol. 2003)
    10. Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton. (PubMed id 8509414)1, 9 Glantz S.B....Rubin C.S. (J. Biol. Chem. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9495 HGNC: 375 AceView: AKAP5 Ensembl:ENSG00000179841 euGenes: HUgn9495
    ECgene: AKAP5 H-InvDB: AKAP5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AKAP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AKAP5 gene:
    Search GeneIP for patents involving AKAP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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