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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AKAP4 Gene

protein-coding   GIFtS: 55
GCID: GC0XM049955

A Kinase (PRKA) Anchor Protein 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
A Kinase (PRKA) Anchor Protein 41 2     AKAP-42 3
A-Kinase Anchor Protein 82 KDa1 2 3     PRKA42 3
AKAP822 3 5     AKAP 822 3
HI2 3 5     hAKAP822 3
Cancer/Testis Antigen 991 2     FSC12 5
Protein Kinase A Anchoring Protein 41 2     CT992
Testis-Specific Gene HI1 2     A-Kinase Anchor Protein 42
Major Sperm Fibrous Sheath Protein2 3     p822
Protein Kinase A-Anchoring Protein 42 3     

External Ids:    HGNC: 3741   Entrez Gene: 88522   Ensembl: ENSG000001470817   OMIM: 3001855   UniProtKB: Q5JQC93   

Export aliases for AKAP4 gene to outside databases

Previous GC identifers: GC0XM048552 GC0XM048011 GC0XM048653 GC0XM048872 GC0XM049658 GC0XM049842 GC0XM047427


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AKAP4 Gene:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function
of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations
within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm
flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in
two transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for AKAP4 Gene: 
AKAP4 (A kinase (PRKA) anchor protein 4) is a protein-coding gene. Diseases associated with AKAP4 include male infertility, and infertility, and among its related super-pathways are Activation of cAMP-Dependent PKA and Signal transduction PKA signaling. GO annotations related to this gene include protein kinase A binding. An important paralog of this gene is AKAP3.

UniProtKB/Swiss-Prot: AKAP4_HUMAN, Q5JQC9
Function: Major structural component of sperm fibrous sheath. Plays a role in sperm motility

Gene Wiki entry for AKAP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_086939.3  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AKAP4 gene promoter:
         HEN1   Pax-2b   Pbx1a   Pax-2   Cart-1   Pax-2a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AKAP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for AKAP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKAP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.2   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.2

AKAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKAP4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM049955:  view genomic region     (about GC identifiers)

Start:
49,955,406 bp from pter      End:
49,965,664 bp from pter
Size:
10,259 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AKAP4_HUMAN, Q5JQC9 (See protein sequence)
Recommended Name: A-kinase anchor protein 4 precursor  
Size: 854 amino acids; 94477 Da
Subunit: Interacts with PRKAR1A and PRKAR2A (By similarity)
Subcellular location: Cell projection, cilium, flagellum. Note=Localizes to the principle piece of the sperm
flagellum
Developmental stage: Post-meiotic phase of spermatogenesis
Sequence caution: Sequence=CAA75494.1; Type=Frameshift; Positions=Several;
Secondary accessions: A0AV85 O60904 O95246 Q5JQD1 Q5JQD2 Q5JQD3
Alternative splicing: 2 isoforms:  Q5JQC9-1   Q5JQC9-2   

Explore the universe of human proteins at neXtProt for AKAP4: NX_Q5JQC9

Explore proteomics data for AKAP4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5JQC9

  • AKAP4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AKAP4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003877.2  NP_647450.1  

    ENSEMBL proteins: 
     ENSP00000351327   ENSP00000365232   ENSP00000402403   ENSP00000412279   ENSP00000365224  
     ENSP00000365226  

    Human Recombinant Protein Products for AKAP4: 
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    Cloud-Clone Corp. Proteins for AKAP4 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005856cytoskeleton TAS9822690
    GO:0005929cilium ----
    GO:0005952cAMP-dependent protein kinase complex NAS9822690
    GO:0030018Z disc IEA--
    GO:0031514motile cilium IDA9822690

    AKAP4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AKAP: A-kinase anchor proteins

    4 InterPro protein domains:
     IPR020799 AKAP_110
     IPR018292 AKAP_110_C
     IPR008382 SPHK1-interactor_AKAP_110
     IPR018459 RII_binding_1

    Graphical View of Domain Structure for InterPro Entry Q5JQC9

    ProtoNet protein and cluster: Q5JQC9

    1 Blocks protein domain: IPB008382 A-kinase anchor 110 kDa

    UniProtKB/Swiss-Prot: AKAP4_HUMAN, Q5JQC9
    Domain: RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein
    interactions with a complementary surface on the R-subunit dimer (By similarity)
    Similarity: Belongs to the AKAP110 family


    AKAP4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKAP4_HUMAN, Q5JQC9
    Function: Major structural component of sperm fibrous sheath. Plays a role in sperm motility

         Genatlas biochemistry entry for AKAP4:
    A kinasen (PRKA regulatory subunit RIIA) anchor protein 4,major human sperm fibrous sheath protein,involved in
    sperm-motility

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0051018protein kinase A binding ISS--
         
    AKAP4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Akap4):
     reproductive system 

    AKAP4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Akap4tm1Eddy for AKAP4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AKAP4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AKAP4

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AKAP4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2Signal transduction PKA signaling
    Signal transduction PKA signaling1.00
    3Signal transduction cAMP signaling
    G Protein Signaling Pathways0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for AKAP4
        Signal transduction PKA signaling

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AKAP4
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 GeneGo (Thomson Reuters) Pathway for AKAP4
        Signal transduction PKA signaling

    1 BioSystems Pathway for AKAP4
        G Protein Signaling Pathways



    AKAP4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AKAP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/13 Interacting proteins for AKAP4 (Q5JQC93 ENSP000003513274) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKAP3O759693, ENSP000002288504I2D: score=4 STRING: ENSP00000228850
    PRKAR1AP106443, ENSP000003514104I2D: score=4 STRING: ENSP00000351410
    PRKAR2AP138613, ENSP000002655634I2D: score=1 STRING: ENSP00000265563
    PRKAR2BP313233, ENSP000002657174I2D: score=1 STRING: ENSP00000265717
    FSIP1Q8NA033, ENSP000002802364I2D: score=4 STRING: ENSP00000280236
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS9822690
    GO:0007165signal transduction TAS9822690
    GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway IEA--
    GO:0007338single fertilization TAS9822690
    GO:0008104protein localization IEA--

    AKAP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AKAP4

    Search CenterWatch for drugs/clinical trials and news about AKAP4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AKAP4 gene (2 alternative transcripts): 
    NM_003886.2  NM_139289.1  

    Unigene Cluster for AKAP4:

    A kinase (PRKA) anchor protein 4
    Hs.97633  [show with all ESTs]
    Unigene Representative Sequence: AF072756
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358526(uc004dow.1) ENST00000376064(uc004dou.1 uc004dov.1)
    ENST00000481402(uc010njp.1) ENST00000448865 ENST00000437370 ENST00000480926
    ENST00000376056 ENST00000376058
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKAP4

    Additional mRNA sequence: 

    AF072756.1 AK292463.1 BC033007.1 BC070150.1 BC126250.1 BC126252.1 Y15195.1 

    4 DOTS entries:

    DT.409908  DT.102820321  DT.100015560  DT.121280741 

    23 AceView cDNA sequences:

    NM_003886 AI025520 AA398240 BC070150 AA868468 NM_139289 AL045518 BX281042 
    AW589820 AA403180 AL079735 BU570088 BC033007 AI041555 BG718271 BI826708 
    BE464028 AF072756 Y15195 BI465187 BF059251 CD300200 AA992768 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AKAP4 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8
    SP1:                                                  -     -     -                                       
    SP2:                                                  -     -     -                                       
    SP3:                                                  -     -     -                                       
    SP4:              -     -                             -     -     -                                       
    SP5:                                                              -                                       


    ECgene alternative splicing isoforms for AKAP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AKAP4 expression in normal human tissues (normalized intensities)      AKAP4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTTTGCCA
    AKAP4 Expression
    About this image


    AKAP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
             testis ; cells in seminiferus ducts   
             sperm   
     
     Endothelium (Cardiovascular System)
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose

    See AKAP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AKAP4

    SOURCE GeneReport for Unigene cluster: Hs.97633

    UniProtKB/Swiss-Prot: AKAP4_HUMAN, Q5JQC9
    Tissue specificity: Testis specific; only expressed in round spermatids

        SABiosciences Custom PCR Arrays for AKAP4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AKAP4 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akap41 , 5 A kinase (PRKA) anchor protein 41, 5 82.98(n)1
    79.27(a)1
      X (3.17 cM)5
    116431  NM_009651.31  NP_033781.21 
     70675195 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    51(a)
    46(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    3(7754318-7756330)
    1(87691007-87692314)


    ENSEMBL Gene Tree for AKAP4 (if available)
    TreeFam Gene Tree for AKAP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AKAP4 gene
    AKAP32  

    AKAP4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/189 SNPs in AKAP4 are shown (see all 189)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011085181,2
    C--47428592(+) GTGTGA/TGAGAG 2 -- int10--------
    rs1874822921,2
    --49958620(+) GTATAC/TGCTTT 2 -- ds50010--------
    rs1929678101,2
    C--49958943(+) TTATTA/TTTTTT 2 -- ut310--------
    rs1130672391,2
    C--49959088(+) GCTAGC/G/TGGGGC 4 -- ut311CSA 2
    rs1484372391,2
    C,F--49959132(+) GTTAGC/TGAGCA 4 T A mis11Minor allele frequency- T:0.01NA 4550
    rs1426096031,2
    F--49959144(+) CCAGTC/TCAGCA 4 N D mis11Minor allele frequency- T:0.00NA 4550
    rs1509752951,2
    C--49959191(+) GTTGCC/TGTTCC 4 Q R mis11Minor allele frequency- T:0.00NA 4550
    rs1932714621,2
    C--49959222(+) TTGAAG/TAAGAC 4 I L mis10--------
    rs786681791,2
    C,F--49959247(+) CCCTTC/TTCTGC 4 E syn12Minor allele frequency- T:0.04CSA NA 4551
    rs734937661,2
    C--49959301(+) AGTGTG/TAGTTG 2 -- int11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for AKAP4 (49955406 - 49965664 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AKAP4: --

    Locus Specific Mutation Databases (LSDB): AKAP4
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300185    OMIM disorders: --

    4 diseases for AKAP4:    About MalaCards
    male infertility    infertility    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for AKAP4:
    Male infertility

    AKAP4 for disorders           About GeneDecksing


    Export disorders for AKAP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AKAP4 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with AKAP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An X-linked gene encodes a major human sperm fibrous sheath protein, hAKAP82. Genomic organization, protein kinase A-RII binding, and distribution of the precursor in the sperm tail. (PubMed id 9822690)1, 2, 3, 9 Turner R.M.O.... Moss S.B. (1998)
    2. Molecular cloning of human testis mRNA specifically expressed in haploid germ cells, having structural homology with the A-kinase anchoring proteins. (PubMed id 9514854)1, 2, 3 Mohapatra B.... Suri A. (1998)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. (PubMed id 12509440)1, 2 Ficarro S....Visconti P.E. (2003)
    6. Localization of AKAP4 and tubulin proteins in sperm with reduced motility. (PubMed id 17712481)1, 9 Moretti E....Collodel G. (2007)
    7. Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. (PubMed id 23077236)1 Vigodner M....Callaway M. (2013)
    8. A novel cancer testis antigen, A-kinase anchor protein 4 (AKAP4) is a potential biomarker for breast cancer. (PubMed id 23451156)1 Saini S....Suri A. (2013)
    9. Identification of AKAP-4 as a new cancer/testis antig en for detection and immunotherapy of prostate cancer. (PubMed id 21520158)1 Chiriva-Internati M....Kast W.M. (2012)
    10. Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide? (PubMed id 17683036)1 Lefievre L....Barratt C.L. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8852 HGNC: 374 AceView: AKAP4 Ensembl:ENSG00000147081 euGenes: HUgn8852
    ECgene: AKAP4 H-InvDB: AKAP4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AKAP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AKAP4 gene:
    Search GeneIP for patents involving AKAP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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