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Aliases for AKAP4 Gene

Aliases for AKAP4 Gene

  • A Kinase (PRKA) Anchor Protein 4 2 3
  • A-Kinase Anchor Protein 82 KDa 2 3 4
  • AKAP82 3 4 6
  • HI 3 4 6
  • Protein Kinase A Anchoring Protein 4 2 3
  • Protein Kinase A-Anchoring Protein 4 3 4
  • Major Sperm Fibrous Sheath Protein 3 4
  • Cancer/Testis Antigen 99 2 3
  • Testis-Specific Gene HI 2 3
  • AKAP 82 3 4
  • HAKAP82 3 4
  • AKAP-4 3 4
  • PRKA4 3 4
  • FSC1 3 6
  • A-Kinase Anchor Protein 4 3
  • CT99 3
  • P82 3

External Ids for AKAP4 Gene

Previous GeneCards Identifiers for AKAP4 Gene

  • GC0XM048552
  • GC0XM048011
  • GC0XM048653
  • GC0XM048872
  • GC0XM049658
  • GC0XM049842
  • GC0XM049955
  • GC0XM047427

Summaries for AKAP4 Gene

Entrez Gene Summary for AKAP4 Gene

  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKAP4 Gene

AKAP4 (A Kinase (PRKA) Anchor Protein 4) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein kinase A binding. An important paralog of this gene is AKAP3.

UniProtKB/Swiss-Prot for AKAP4 Gene

  • Major structural component of sperm fibrous sheath. Plays a role in sperm motility.

Gene Wiki entry for AKAP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP4 Gene

Genomics for AKAP4 Gene

Regulatory Elements for AKAP4 Gene

Genomic Location for AKAP4 Gene

50,190,768 bp from pter
50,201,013 bp from pter
10,246 bases
Minus strand

Genomic View for AKAP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP4 Gene

Proteins for AKAP4 Gene

  • Protein details for AKAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A-kinase anchor protein 4
    Protein Accession:
    Secondary Accessions:
    • A0AV85
    • O60904
    • O95246
    • Q5JQD1
    • Q5JQD2
    • Q5JQD3

    Protein attributes for AKAP4 Gene

    854 amino acids
    Molecular mass:
    94477 Da
    Quaternary structure:
    • Interacts with PRKAR1A and PRKAR2A.
    • Sequence=CAA75494.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for AKAP4 Gene


neXtProt entry for AKAP4 Gene

Proteomics data for AKAP4 Gene at MOPED

Post-translational modifications for AKAP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKAP4 Gene

Antibody Products

No data available for DME Specific Peptides for AKAP4 Gene

Domains for AKAP4 Gene

Gene Families for AKAP4 Gene

  • AKAP :A-kinase anchor proteins

Protein Domains for AKAP4 Gene

Suggested Antigen Peptide Sequences for AKAP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5JQC9
  • RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
  • Belongs to the AKAP110 family.
genes like me logo Genes that share domains with AKAP4: view

Function for AKAP4 Gene

Molecular function for AKAP4 Gene

GENATLAS Biochemistry:
A kinasen (PRKA regulatory subunit RIIA) anchor protein 4,major human sperm fibrous sheath protein,involved in sperm-motility
UniProtKB/Swiss-Prot Function:
Major structural component of sperm fibrous sheath. Plays a role in sperm motility.

Gene Ontology (GO) - Molecular Function for AKAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0051018 protein kinase A binding ISS --
genes like me logo Genes that share ontologies with AKAP4: view

Phenotypes for AKAP4 Gene

MGI mutant phenotypes for AKAP4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with AKAP4: view

Animal Models for AKAP4 Gene

MGI Knock Outs for AKAP4:

Animal Model Products

miRNA for AKAP4 Gene

miRTarBase miRNAs that target AKAP4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKAP4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AKAP4 Gene

Localization for AKAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP4 Gene

Cell projection, cilium, flagellum. Note=Localizes to the principle piece of the sperm flagellum.

Subcellular locations from

Jensen Localization Image for AKAP4 Gene COMPARTMENTS Subcellular localization image for AKAP4 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for AKAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IBA --
GO:0005856 cytoskeleton TAS 9822690
GO:0005929 cilium --
GO:0005952 cAMP-dependent protein kinase complex NAS 9822690
genes like me logo Genes that share ontologies with AKAP4: view

Pathways for AKAP4 Gene

genes like me logo Genes that share pathways with AKAP4: view

Pathways by source for AKAP4 Gene

1 GeneGo (Thomson Reuters) pathway for AKAP4 Gene

Gene Ontology (GO) - Biological Process for AKAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9822690
GO:0007165 signal transduction TAS 9822690
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA --
GO:0007338 single fertilization TAS 9822690
GO:0008104 protein localization IEA --
genes like me logo Genes that share ontologies with AKAP4: view

Transcripts for AKAP4 Gene

Unigene Clusters for AKAP4 Gene

A kinase (PRKA) anchor protein 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKAP4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: -
SP6: - - -
SP7: - -

Relevant External Links for AKAP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AKAP4 Gene

mRNA expression in normal human tissues for AKAP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AKAP4 Gene

This gene is overexpressed in Testis (52.6).

Protein differential expression in normal tissues for AKAP4 Gene

This gene is overexpressed in Testis (33.6) and Ovary (31.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AKAP4 Gene

SOURCE GeneReport for Unigene cluster for AKAP4 Gene Hs.97633

mRNA Expression by UniProt/SwissProt for AKAP4 Gene

Tissue specificity: Testis specific; only expressed in round spermatids.
genes like me logo Genes that share expressions with AKAP4: view

Expression partners for AKAP4 Gene

In Situ Assay Products

Orthologs for AKAP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AKAP4 35
  • 83.87 (n)
  • 78.7 (a)
AKAP4 36
  • 78 (a)
(Canis familiaris)
Mammalia AKAP4 35
  • 88.44 (n)
  • 84.02 (a)
AKAP4 36
  • 83 (a)
(Mus musculus)
Mammalia Akap4 35
  • 83.02 (n)
  • 79.27 (a)
Akap4 16
Akap4 36
  • 78 (a)
(Pan troglodytes)
Mammalia AKAP4 35
  • 99.53 (n)
  • 99.47 (a)
(Rattus norvegicus)
Mammalia Akap4 35
  • 82.84 (n)
  • 78.65 (a)
(Monodelphis domestica)
Mammalia AKAP4 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
-- 36
  • 68 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
-- 36
  • 41 (a)
-- 36
  • 53 (a)
Species with no ortholog for AKAP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AKAP4 Gene

Gene Tree for AKAP4 (if available)
Gene Tree for AKAP4 (if available)

Paralogs for AKAP4 Gene

Paralogs for AKAP4 Gene

genes like me logo Genes that share paralogs with AKAP4: view

Variants for AKAP4 Gene

Sequence variations from dbSNP and Humsavar for AKAP4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1132159 -- 50,193,128(-) ATGAG(A/T)AAGGA reference, stop-gained
rs1132160 -- 50,193,119(-) GAGAA(A/T)AGATC reference, stop-gained
rs1132161 -- 50,193,034(-) GCAGA(C/T)TAAGG reference, missense
rs1132166 -- 50,191,112(-) AGCTT(C/G)CTCAG reference, missense
rs5905792 -- 50,191,523(+) AGGGA(C/G)GATTG intron-variant

Relevant External Links for AKAP4 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AKAP4 Gene

Disorders for AKAP4 Gene

(1) University of Copenhagen DISEASES for AKAP4 Gene

genes like me logo Genes that share disorders with AKAP4: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for AKAP4 Gene

Publications for AKAP4 Gene

  1. An X-linked gene encodes a major human sperm fibrous sheath protein, hAKAP82. Genomic organization, protein kinase A-RII binding, and distribution of the precursor in the sperm tail. (PMID: 9822690) Turner R.M.O. … Moss S.B. (J. Biol. Chem. 1998) 2 3 4 23
  2. Molecular cloning of human testis mRNA specifically expressed in haploid germ cells, having structural homology with the A-kinase anchoring proteins. (PMID: 9514854) Mohapatra B. … Suri A. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. Localization of AKAP4 and tubulin proteins in sperm with reduced motility. (PMID: 17712481) Moretti E. … Collodel G. (Asian J. Androl. 2007) 3 23

Products for AKAP4 Gene

Sources for AKAP4 Gene

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