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AKAP4 Gene

protein-coding   GIFtS: 55
GCID: GC0XM049955

A Kinase (PRKA) Anchor Protein 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
A Kinase (PRKA) Anchor Protein 41 2     AKAP-42 3
A-Kinase Anchor Protein 82 KDa1 2 3     PRKA42 3
AKAP822 3 5     AKAP 822 3
HI2 3 5     hAKAP822 3
Cancer/Testis Antigen 991 2     FSC12 5
Protein Kinase A Anchoring Protein 41 2     CT992
Testis-Specific Gene HI1 2     A-Kinase Anchor Protein 42
Major Sperm Fibrous Sheath Protein2 3     p822
Protein Kinase A-Anchoring Protein 42 3     

External Ids:    HGNC: 3741   Entrez Gene: 88522   Ensembl: ENSG000001470817   OMIM: 3001855   UniProtKB: Q5JQC93   

Export aliases for AKAP4 gene to outside databases

Previous GC identifers: GC0XM048552 GC0XM048011 GC0XM048653 GC0XM048872 GC0XM049658 GC0XM049842 GC0XM047427


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AKAP4 Gene:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function
of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations
within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm
flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in
two transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for AKAP4 Gene:
AKAP4 (A kinase (PRKA) anchor protein 4) is a protein-coding gene. GO annotations related to this gene include protein kinase A binding. An important paralog of this gene is AKAP3.

UniProtKB/Swiss-Prot: AKAP4_HUMAN, Q5JQC9
Function: Major structural component of sperm fibrous sheath. Plays a role in sperm motility

Gene Wiki entry for AKAP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the AKAP4 gene promoter:
         HEN1   Pax-2b   Pbx1a   Pax-2   Cart-1   Pax-2a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AKAP4 promoter sequence
   Search Chromatin IP Primers for AKAP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKAP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.2   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.2

AKAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKAP4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM049955:  view genomic region     (about GC identifiers)

Start:
49,955,406 bp from pter      End:
49,965,664 bp from pter
Size:
10,259 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AKAP4_HUMAN, Q5JQC9 (See protein sequence)
Recommended Name: A-kinase anchor protein 4 precursor  
Size: 854 amino acids; 94477 Da
Subunit: Interacts with PRKAR1A and PRKAR2A (By similarity)
Developmental stage: Post-meiotic phase of spermatogenesis
Sequence caution: Sequence=CAA75494.1; Type=Frameshift; Positions=Several;
Secondary accessions: A0AV85 O60904 O95246 Q5JQD1 Q5JQD2 Q5JQD3
Alternative splicing: 2 isoforms:  Q5JQC9-1   Q5JQC9-2   

Explore the universe of human proteins at neXtProt for AKAP4: NX_Q5JQC9

Explore proteomics data for AKAP4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AKAP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003877.2  NP_647450.1  

    ENSEMBL proteins: 
     ENSP00000351327   ENSP00000365232   ENSP00000402403   ENSP00000412279   ENSP00000365224  
     ENSP00000365226  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AKAP: A-kinase anchor proteins

    4 InterPro protein domains:
     IPR020799 AKAP_110
     IPR018292 AKAP_110_C
     IPR008382 SPHK1-interactor_AKAP_110
     IPR018459 RII_binding_1

    Graphical View of Domain Structure for InterPro Entry Q5JQC9

    ProtoNet protein and cluster: Q5JQC9

    1 Blocks protein domain: IPB008382 A-kinase anchor 110 kDa

    UniProtKB/Swiss-Prot: AKAP4_HUMAN, Q5JQC9
    Domain: RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein
    interactions with a complementary surface on the R-subunit dimer (By similarity)
    Similarity: Belongs to the AKAP110 family


    Find genes that share domains with AKAP4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKAP4_HUMAN, Q5JQC9
    Function: Major structural component of sperm fibrous sheath. Plays a role in sperm motility

         Genatlas biochemistry entry for AKAP4:
    A kinasen (PRKA regulatory subunit RIIA) anchor protein 4,major human sperm fibrous sheath protein,involved in
    sperm-motility

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0051018protein kinase A binding ISS--
         
    Find genes that share ontologies with AKAP4           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Akap4):
     reproductive system 

    Find genes that share phenotypes with AKAP4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Akap4tm1Eddy for AKAP4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AKAP4
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    hsa-mir-124-3p (MIRT022331), hsa-mir-1 (MIRT023610)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AKAP4_HUMAN, Q5JQC9: Cell projection, cilium, flagellum. Note=Localizes to the principle piece of the sperm
    flagellum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005856cytoskeleton TAS9822690
    GO:0005929cilium ----
    GO:0005952cAMP-dependent protein kinase complex NAS9822690
    GO:0030018Z disc IEA--
    GO:0031514motile cilium IDA9822690

    Find genes that share ontologies with AKAP4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AKAP4 About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    3Signal transduction PKA signaling
    Signal transduction PKA signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AKAP4
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 GeneGo (Thomson Reuters) Pathway for AKAP4
        Signal transduction PKA signaling

    1 BioSystems Pathway for AKAP4
        G Protein Signaling Pathways


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AKAP4
    Interactions:

        GeneGlobe Interaction Network for AKAP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for AKAP4 (Q5JQC93 ENSP000003513274) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKAP3O759693, ENSP000002288504I2D: score=4 STRING: ENSP00000228850
    PRKAR1AP106443, ENSP000003514104I2D: score=4 STRING: ENSP00000351410
    PRKAR2AP138613, ENSP000002655634I2D: score=1 STRING: ENSP00000265563
    PRKAR2BP313233, ENSP000002657174I2D: score=1 STRING: ENSP00000265717
    FSIP1Q8NA033, ENSP000002802364I2D: score=4 STRING: ENSP00000280236
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS9822690
    GO:0007165signal transduction TAS9822690
    GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway IEA--
    GO:0007338single fertilization TAS9822690
    GO:0008104protein localization IEA--

    Find genes that share ontologies with AKAP4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for AKAP4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AKAP4 gene (2 alternative transcripts): 
    NM_003886.2  NM_139289.1  

    Unigene Cluster for AKAP4:

    A kinase (PRKA) anchor protein 4
    Hs.97633  [show with all ESTs]
    Unigene Representative Sequence: AF072756
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358526(uc004dow.1) ENST00000376064(uc004dou.1 uc004dov.1)
    ENST00000481402(uc010njp.1) ENST00000448865 ENST00000437370 ENST00000480926
    ENST00000376056 ENST00000376058
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat AKAP4

    Additional mRNA sequence: 

    AF072756.1 AK292463.1 BC033007.1 BC070150.1 BC126250.1 BC126252.1 Y15195.1 

    4 DOTS entries:

    DT.409908  DT.102820321  DT.100015560  DT.121280741 

    23 AceView cDNA sequences:

    AW589820 BC070150 BX281042 NM_003886 AL045518 AA398240 AA868468 NM_139289 
    AI025520 AF072756 AA403180 AI041555 BG718271 Y15195 BC033007 BI826708 
    BU570088 AL079735 BE464028 CD300200 BF059251 BI465187 AA992768 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AKAP4 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8
    SP1:                                                  -     -     -                                       
    SP2:                                                  -     -     -                                       
    SP3:                                                  -     -     -                                       
    SP4:              -     -                             -     -     -                                       
    SP5:                                                              -                                       


    ECgene alternative splicing isoforms for AKAP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AKAP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTTTGCCA
    AKAP4 Expression
    About this image


    AKAP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced embryoid bodies
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Subcutaneous White Adipose
    AKAP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKAP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.97633

    UniProtKB/Swiss-Prot: AKAP4_HUMAN, Q5JQC9
    Tissue specificity: Testis specific; only expressed in round spermatids

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AKAP4 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akap41 , 5 A kinase (PRKA) anchor protein 41, 5 83.02(n)1
    79.27(a)1
      X (3.17 cM)5
    116431  NM_009651.31  NP_033781.21 
     70675195 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    53(a)
    48(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    3(7754318-7756330)
    1(87691007-87692314)


    ENSEMBL Gene Tree for AKAP4 (if available)
    TreeFam Gene Tree for AKAP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AKAP4 gene
    AKAP32  

    Find genes that share paralogs with AKAP4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AKAP4 (see all 189)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011085181,2
    C--47428592(+) GTGTGA/TGAGAG 2 -- int10--------
    rs1874822921,2
    --49958620(+) GTATAC/TGCTTT 2 -- ds50010--------
    rs1929678101,2
    C--49958943(+) TTATTA/TTTTTT 2 -- ut310--------
    rs1130672391,2
    C--49959088(+) GCTAGC/G/TGGGGC 4 -- ut311CSA 2
    rs1484372391,2
    C,F--49959132(+) GTTAGC/TGAGCA 4 T A mis11Minor allele frequency- T:0.01NA 4550
    rs1426096031,2
    F--49959144(+) CCAGTC/TCAGCA 4 N D mis11Minor allele frequency- T:0.00NA 4550
    rs1509752951,2
    C--49959191(+) GTTGCC/TGTTCC 4 Q R mis11Minor allele frequency- T:0.00NA 4550
    rs1932714621,2
    C--49959222(+) TTGAAG/TAAGAC 4 I L mis10--------
    rs786681791,2
    C,F--49959247(+) CCCTTC/TTCTGC 4 E syn12Minor allele frequency- T:0.04CSA NA 4551
    rs734937661,2
    C--49959301(+) AGTGTG/TAGTTG 2 -- int11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for AKAP4 (49955406 - 49965664 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AKAP4: --
    Locus Specific Mutation Databases (LSDB): AKAP4

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing AKAP4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300185    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for AKAP4:
    Male infertility

    Find genes that share disorders with AKAP4           About GenesLikeMe


    Export disorders for AKAP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AKAP4 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with AKAP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An X-linked gene encodes a major human sperm fibrous sheath protein, hAKAP82. Genomic organization, protein kinase A-RII binding, and distribution of the precursor in the sperm tail. (PubMed id 9822690)1, 2, 3, 9 Turner R.M.O.... Moss S.B. (J. Biol. Chem. 1998)
    2. Molecular cloning of human testis mRNA specifically expressed in haploid germ cells, having structural homology with the A-kinase anchoring proteins. (PubMed id 9514854)1, 2, 3 Mohapatra B.... Suri A. (Biochem. Biophys. Res. Commun. 1998)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin- containing protein/p97 during capacitation. (PubMed id 12509440)1, 2 Ficarro S....Visconti P.E. (J. Biol. Chem. 2003)
    6. Localization of AKAP4 and tubulin proteins in sperm with reduced motility. (PubMed id 17712481)1, 9 Moretti E....Collodel G. (Asian J. Androl. 2007)
    7. Gene silencing of A-kinase anchor protein 4 inhibits cervical cancer growth in vitro and in vivo. (PubMed id 23764900)1 Saini S....Suri A. (Cancer Gene Ther. 2013)
    8. Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. (PubMed id 23077236)1 Vigodner M....Callaway M. (Hum. Reprod. 2013)
    9. Expression and humoral response of A-kinase anchor protein 4 in cervical cancer. (PubMed id 23478221)1 Agarwal S....Suri A. (Int. J. Gynecol. Cancer 2013)
    10. A novel cancer testis antigen, A-kinase anchor protein 4 (AKAP4) is a potential biomarker for breast cancer. (PubMed id 23451156)1 Saini S....Suri A. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8852 HGNC: 374 AceView: AKAP4 Ensembl:ENSG00000147081 euGenes: HUgn8852
    ECgene: AKAP4 H-InvDB: AKAP4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AKAP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AKAP4 gene:
    Search GeneIP for patents involving AKAP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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