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Aliases for AKAP4 Gene

Aliases for AKAP4 Gene

  • A-Kinase Anchoring Protein 4 2 3 5
  • A-Kinase Anchor Protein 82 KDa 2 3 4
  • Protein Kinase A Anchoring Protein 4 2 3
  • Protein Kinase A-Anchoring Protein 4 3 4
  • Major Sperm Fibrous Sheath Protein 3 4
  • A Kinase (PRKA) Anchor Protein 4 2 3
  • Cancer/Testis Antigen 99 2 3
  • Testis-Specific Gene HI 2 3
  • AKAP 82 3 4
  • HAKAP82 3 4
  • AKAP-4 3 4
  • AKAP82 3 4
  • PRKA4 3 4
  • HI 3 4
  • CT99 3
  • FSC1 3
  • P82 3

External Ids for AKAP4 Gene

Previous GeneCards Identifiers for AKAP4 Gene

  • GC0XM048552
  • GC0XM048011
  • GC0XM048653
  • GC0XM048872
  • GC0XM049658
  • GC0XM049842
  • GC0XM049955
  • GC0XM047427

Summaries for AKAP4 Gene

Entrez Gene Summary for AKAP4 Gene

  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKAP4 Gene

AKAP4 (A-Kinase Anchoring Protein 4) is a Protein Coding gene. Among its related pathways are G Protein Signaling Pathways and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein kinase A binding. An important paralog of this gene is AKAP3.

UniProtKB/Swiss-Prot for AKAP4 Gene

  • Major structural component of sperm fibrous sheath. Plays a role in sperm motility.

Gene Wiki entry for AKAP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP4 Gene

Genomics for AKAP4 Gene

Regulatory Elements for AKAP4 Gene

Genomic Location for AKAP4 Gene

Chromosome:
X
Start:
50,190,768 bp from pter
End:
50,201,013 bp from pter
Size:
10,246 bases
Orientation:
Minus strand

Genomic View for AKAP4 Gene

Genes around AKAP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP4 Gene

Proteins for AKAP4 Gene

  • Protein details for AKAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JQC9-AKAP4_HUMAN
    Recommended name:
    A-kinase anchor protein 4
    Protein Accession:
    Q5JQC9
    Secondary Accessions:
    • A0AV85
    • O60904
    • O95246
    • Q5JQD1
    • Q5JQD2
    • Q5JQD3

    Protein attributes for AKAP4 Gene

    Size:
    854 amino acids
    Molecular mass:
    94477 Da
    Quaternary structure:
    • Interacts with PRKAR1A and PRKAR2A. Interacts with ENO4.
    SequenceCaution:
    • Sequence=CAA75494.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for AKAP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKAP4 Gene

Proteomics data for AKAP4 Gene at MOPED

Post-translational modifications for AKAP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKAP4 Gene

Antibody Products

No data available for DME Specific Peptides for AKAP4 Gene

Domains & Families for AKAP4 Gene

Gene Families for AKAP4 Gene

Protein Domains for AKAP4 Gene

Suggested Antigen Peptide Sequences for AKAP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JQC9

UniProtKB/Swiss-Prot:

AKAP4_HUMAN :
  • RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
  • Belongs to the AKAP110 family.
Domain:
  • RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Family:
  • Belongs to the AKAP110 family.
genes like me logo Genes that share domains with AKAP4: view

Function for AKAP4 Gene

Molecular function for AKAP4 Gene

GENATLAS Biochemistry:
A kinasen (PRKA regulatory subunit RIIA) anchor protein 4,major human sperm fibrous sheath protein,involved in sperm-motility
UniProtKB/Swiss-Prot Function:
Major structural component of sperm fibrous sheath. Plays a role in sperm motility.
genes like me logo Genes that share phenotypes with AKAP4: view

Animal Models for AKAP4 Gene

MGI Knock Outs for AKAP4:

Animal Model Products

miRNA for AKAP4 Gene

miRTarBase miRNAs that target AKAP4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AKAP4 Gene

Localization for AKAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP4 Gene

Cell projection, cilium, flagellum. Note=Localizes to the principle piece of the sperm flagellum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP4 Gene COMPARTMENTS Subcellular localization image for AKAP4 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for AKAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
GO:0030018 Z disc IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with AKAP4: view

Pathways & Interactions for AKAP4 Gene

genes like me logo Genes that share pathways with AKAP4: view

Pathways by source for AKAP4 Gene

1 BioSystems pathway for AKAP4 Gene
1 GeneGo (Thomson Reuters) pathway for AKAP4 Gene

Gene Ontology (GO) - Biological Process for AKAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9822690
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA --
GO:0045184 establishment of protein localization IEA --
genes like me logo Genes that share ontologies with AKAP4: view

No data available for SIGNOR curated interactions for AKAP4 Gene

Drugs & Compounds for AKAP4 Gene

No Compound Related Data Available

Transcripts for AKAP4 Gene

Unigene Clusters for AKAP4 Gene

A kinase (PRKA) anchor protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: -
SP6: - - -
SP7: - -

Relevant External Links for AKAP4 Gene

GeneLoc Exon Structure for
AKAP4
ECgene alternative splicing isoforms for
AKAP4

Expression for AKAP4 Gene

mRNA expression in normal human tissues for AKAP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AKAP4 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for AKAP4 Gene

This gene is overexpressed in Testis (33.6) and Ovary (31.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AKAP4 Gene



SOURCE GeneReport for Unigene cluster for AKAP4 Gene Hs.97633

mRNA Expression by UniProt/SwissProt for AKAP4 Gene

Q5JQC9-AKAP4_HUMAN
Tissue specificity: Testis specific; only expressed in round spermatids.
genes like me logo Genes that share expression patterns with AKAP4: view

Protein tissue co-expression partners for AKAP4 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for AKAP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AKAP4 35
  • 83.87 (n)
  • 78.7 (a)
AKAP4 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKAP4 35
  • 88.44 (n)
  • 84.02 (a)
AKAP4 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akap4 35
  • 83.02 (n)
  • 79.27 (a)
Akap4 16
Akap4 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AKAP4 35
  • 99.53 (n)
  • 99.47 (a)
rat
(Rattus norvegicus)
Mammalia Akap4 35
  • 82.84 (n)
  • 78.65 (a)
oppossum
(Monodelphis domestica)
Mammalia AKAP4 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
Species with no ortholog for AKAP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AKAP4 Gene

ENSEMBL:
Gene Tree for AKAP4 (if available)
TreeFam:
Gene Tree for AKAP4 (if available)

Paralogs for AKAP4 Gene

Paralogs for AKAP4 Gene

genes like me logo Genes that share paralogs with AKAP4: view

Variants for AKAP4 Gene

Sequence variations from dbSNP and Humsavar for AKAP4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs12012704 - 50,192,695(+) CTTCC(A/C/G)CTTTG reference, missense
rs17174078 - 50,194,015(+) CCTTA(C/T)GGGCC reference, missense
rs1132159 -- 50,193,128(-) ATGAG(A/T)AAGGA reference, stop-gained
rs1132160 -- 50,193,119(-) GAGAA(A/T)AGATC reference, stop-gained
rs1132161 -- 50,193,034(-) GCAGA(C/T)TAAGG reference, missense

Variation tolerance for AKAP4 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKAP4 Gene

HapMap Linkage Disequilibrium report
AKAP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AKAP4 Gene

Disorders for AKAP4 Gene

Relevant External Links for AKAP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKAP4

No disorders were found for AKAP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKAP4 Gene

Publications for AKAP4 Gene

  1. An X-linked gene encodes a major human sperm fibrous sheath protein, hAKAP82. Genomic organization, protein kinase A-RII binding, and distribution of the precursor in the sperm tail. (PMID: 9822690) Turner R.M.O. … Moss S.B. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Localization of AKAP4 and tubulin proteins in sperm with reduced motility. (PMID: 17712481) Moretti E. … Collodel G. (Asian J. Androl. 2007) 3 23
  3. Molecular cloning of human testis mRNA specifically expressed in haploid germ cells, having structural homology with the A-kinase anchoring proteins. (PMID: 9514854) Mohapatra B. … Suri A. (Biochem. Biophys. Res. Commun. 1998) 2 3
  4. A novel cancer testis antigen, A-kinase anchor protein 4 (AKAP4) is a potential biomarker for breast cancer. (PMID: 23451156) Saini S. … Suri A. (PLoS ONE 2013) 3
  5. Expression and humoral response of A-kinase anchor protein 4 in cervical cancer. (PMID: 23478221) Agarwal S. … Suri A. (Int. J. Gynecol. Cancer 2013) 3

Products for AKAP4 Gene

Sources for AKAP4 Gene

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