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Aliases for AKAP3 Gene

Aliases for AKAP3 Gene

  • A-Kinase Anchoring Protein 3 2 3 5
  • Fibrous Sheath Protein Of 95 KDa 2 3 4
  • Cancer/Testis Antigen 82 2 3 4
  • Protein Kinase A-Anchoring Protein 3 3 4
  • A Kinase (PRKA) Anchor Protein 3 2 3
  • Fibrousheathin I 3 4
  • Fibrousheathin-1 3 4
  • AKAP 110 3 4
  • AKAP110 3 4
  • FSP95 3 4
  • PRKA3 3 4
  • CT82 3 4
  • SOB1 3 4
  • Protein Kinase A Binding Protein AKAP 110 3
  • A-Kinase Anchor Protein, 110kDa 3
  • A-Kinase Anchor Protein 110 KDa 4
  • Epididymis Luminal Protein 159 3
  • Sperm Oocyte-Binding Protein 1 3
  • Sperm Oocyte-Binding Protein 4
  • A-Kinase Anchor Protein 3 3
  • HEL159 3
  • AKAP-3 4

External Ids for AKAP3 Gene

Previous GeneCards Identifiers for AKAP3 Gene

  • GC12M004462
  • GC12M004617
  • GC12M004594
  • GC12M004724

Summaries for AKAP3 Gene

Entrez Gene Summary for AKAP3 Gene

  • This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013]

GeneCards Summary for AKAP3 Gene

AKAP3 (A-Kinase Anchoring Protein 3) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and DAG and IP3 signaling. GO annotations related to this gene include protein kinase A binding. An important paralog of this gene is AKAP4.

UniProtKB/Swiss-Prot for AKAP3 Gene

  • May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.

Gene Wiki entry for AKAP3 Gene

Additional gene information for AKAP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP3 Gene

Genomics for AKAP3 Gene

Regulatory Elements for AKAP3 Gene

Enhancers for AKAP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H004647 1 ENCODE 41.1 0.0 -6 2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ETS1 ZNF121 ZNF207 ZNF143 AKAP3 LOC103568124 LOC101929549 KCNA6 GALNT8 DYRK4 LOC100420673 NDUFA9
GH12H004564 0.9 Ensembl ENCODE 15.9 +82.4 82355 4 ZNF687 NR2F1 BHLHE40 ELF1 DPF2 IKZF1 HMBOX1 NBN IKZF2 SPI1 AKAP3 RAD51AP1 C12orf4 LOC103568124 NDUFA9 TIGAR DYRK4
GH12H004661 0.4 FANTOM5 17.1 -12.1 -12080 0 PRDM1 AKAP3 LOC103568124 DYRK4 GALNT8 KCNA6 LOC101929549 C12orf4 RAD51AP1 ENSG00000255639
GH12H004561 0.9 ENCODE 5.5 +86.9 86860 1 ARID4B KLF17 GLIS2 SP5 MXD4 REST KAT8 ZNF592 TFDP1 RFX3 RAD51AP1 C12orf4 AKAP3 DYRK4 GC12M004550
GH12H004587 0.2 ENCODE 10.7 +61.7 61718 0 C12orf4 RAD51AP1 DYRK4 GALNT8 LOC101929549 KCNA6 NDUFA9 AKAP3 LOC103568124
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AKAP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for AKAP3 Gene

Chromosome:
12
Start:
4,615,508 bp from pter
End:
4,649,047 bp from pter
Size:
33,540 bases
Orientation:
Minus strand

Genomic View for AKAP3 Gene

Genes around AKAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP3 Gene

Proteins for AKAP3 Gene

  • Protein details for AKAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75969-AKAP3_HUMAN
    Recommended name:
    A-kinase anchor protein 3
    Protein Accession:
    O75969
    Secondary Accessions:
    • O75945
    • Q86X01
    • Q9UM61

    Protein attributes for AKAP3 Gene

    Size:
    853 amino acids
    Molecular mass:
    94751 Da
    Quaternary structure:
    • Interacts with ROPN1 AND ROPN1L.

neXtProt entry for AKAP3 Gene

Post-translational modifications for AKAP3 Gene

No data available for DME Specific Peptides for AKAP3 Gene

Domains & Families for AKAP3 Gene

Gene Families for AKAP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AKAP3 Gene

Suggested Antigen Peptide Sequences for AKAP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75969

UniProtKB/Swiss-Prot:

AKAP3_HUMAN :
  • RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
  • Belongs to the AKAP110 family.
Domain:
  • RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Family:
  • Belongs to the AKAP110 family.
genes like me logo Genes that share domains with AKAP3: view

Function for AKAP3 Gene

Molecular function for AKAP3 Gene

GENATLAS Biochemistry:
A kinase (PRKA regulatory subunit RIIA) anchor protein 3,may be involved in oocyte recognition,sperm-oocyte binding protein
UniProtKB/Swiss-Prot Function:
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.

Phenotypes From GWAS Catalog for AKAP3 Gene

Gene Ontology (GO) - Molecular Function for AKAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11278869
GO:0051018 protein kinase A binding IBA,TAS --
genes like me logo Genes that share ontologies with AKAP3: view
genes like me logo Genes that share phenotypes with AKAP3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for AKAP3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AKAP3 Gene

Localization for AKAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP3 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKAP3 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for AKAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IBA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with AKAP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AKAP3 Gene

Pathways & Interactions for AKAP3 Gene

genes like me logo Genes that share pathways with AKAP3: view

Pathways by source for AKAP3 Gene

1 BioSystems pathway for AKAP3 Gene
1 GeneGo (Thomson Reuters) pathway for AKAP3 Gene

Gene Ontology (GO) - Biological Process for AKAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 10319321
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA --
GO:0007338 single fertilization TAS 10319321
GO:0007340 acrosome reaction TAS 10319321
GO:0008104 protein localization IEA --
genes like me logo Genes that share ontologies with AKAP3: view

No data available for SIGNOR curated interactions for AKAP3 Gene

Drugs & Compounds for AKAP3 Gene

(1) Additional Compounds for AKAP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with AKAP3: view

Transcripts for AKAP3 Gene

Unigene Clusters for AKAP3 Gene

A kinase (PRKA) anchor protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for AKAP3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5
SP1: -
SP2:
SP3: - -

Relevant External Links for AKAP3 Gene

GeneLoc Exon Structure for
AKAP3
ECgene alternative splicing isoforms for
AKAP3

Expression for AKAP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AKAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AKAP3 Gene

This gene is overexpressed in Testis (x36.0).

Protein differential expression in normal tissues from HIPED for AKAP3 Gene

This gene is overexpressed in Ovary (38.5) and Testis (29.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AKAP3 Gene



Protein tissue co-expression partners for AKAP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AKAP3 Gene:

AKAP3

SOURCE GeneReport for Unigene cluster for AKAP3 Gene:

Hs.98397

mRNA Expression by UniProt/SwissProt for AKAP3 Gene:

O75969-AKAP3_HUMAN
Tissue specificity: Testis specific; only expressed in spermatids.
genes like me logo Genes that share expression patterns with AKAP3: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AKAP3 Gene

Orthologs for AKAP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKAP3 33 34
  • 98.67 (n)
dog
(Canis familiaris)
Mammalia AKAP3 33 34
  • 85.95 (n)
cow
(Bos Taurus)
Mammalia AKAP3 33 34
  • 80.22 (n)
rat
(Rattus norvegicus)
Mammalia Akap3 33
  • 79.42 (n)
mouse
(Mus musculus)
Mammalia Akap3 33 16 34
  • 78.91 (n)
oppossum
(Monodelphis domestica)
Mammalia AKAP3 34
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKAP3 34
  • 38 (a)
OneToOne
Species where no ortholog for AKAP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AKAP3 Gene

ENSEMBL:
Gene Tree for AKAP3 (if available)
TreeFam:
Gene Tree for AKAP3 (if available)

Paralogs for AKAP3 Gene

Paralogs for AKAP3 Gene

genes like me logo Genes that share paralogs with AKAP3: view

Variants for AKAP3 Gene

Sequence variations from dbSNP and Humsavar for AKAP3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs143517596 A colorectal cancer sample 4,615,810(+) CTGGC(A/G)CTCCT reference, missense
rs780895352 Likely benign 4,649,157(+) TTGTC(C/T)GGGTC upstream-variant-2KB, reference, missense
rs35155742 Benign 4,649,139(+) TTGTG(C/G)GGCAG upstream-variant-2KB, reference, missense
rs1000084680 -- 4,646,349(+) AAAGC(A/G)GCTGG intron-variant, upstream-variant-2KB
rs1000283849 -- 4,633,187(+) GAGGC(C/T)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKAP3 Gene

Variant ID Type Subtype PubMed ID
esv1007580 CNV insertion 20482838
esv2745449 CNV deletion 23290073
esv3326330 CNV insertion 20981092
nsv1036308 CNV loss 25217958
nsv1040098 CNV gain 25217958
nsv468986 CNV loss 19166990
nsv483060 CNV loss 15286789
nsv557123 CNV gain 21841781
nsv557124 CNV loss 21841781
nsv557125 CNV loss 21841781
nsv557126 CNV loss 21841781
nsv587 CNV insertion 18451855
nsv7226 OTHER inversion 18451855
nsv826200 CNV gain 20364138
nsv832318 CNV gain 17160897

Variation tolerance for AKAP3 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.73; 86.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKAP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP3 Gene

Disorders for AKAP3 Gene

Relevant External Links for AKAP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKAP3

No disorders were found for AKAP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKAP3 Gene

Publications for AKAP3 Gene

  1. Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein. (PMID: 10319321) Vijayaraghavan S … Carr DW (Molecular endocrinology (Baltimore, Md.) 1999) 2 3 4 22 60
  2. FSP95, a testis-specific 95-kilodalton fibrous sheath antigen that undergoes tyrosine phosphorylation in capacitated human spermatozoa. (PMID: 10529264) Mandal A … Herr JC (Biology of reproduction 1999) 3 4 22 60
  3. Cloning and characterization of SOB1, a new testis-specific cDNA encoding a human sperm protein probably involved in oocyte recognition. (PMID: 10334916) Lefevre A … Finaz C (Biochemical and biophysical research communications 1999) 2 3 4 60
  4. A-kinase anchoring protein 3 messenger RNA expression correlates with poor prognosis in epithelial ovarian cancer. (PMID: 16005946) Sharma S … Odunsi K (Gynecologic oncology 2005) 3 22 60
  5. Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. (PMID: 15257753) Lea IA … O'Rand MG (Reproductive biology and endocrinology : RB&E 2004) 3 22 60

Products for AKAP3 Gene

Sources for AKAP3 Gene

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