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Aliases for AKAP3 Gene

Aliases for AKAP3 Gene

  • A Kinase (PRKA) Anchor Protein 3 2 3
  • Fibrous Sheath Protein Of 95 KDa 2 3 4
  • Cancer/Testis Antigen 82 2 3 4
  • Protein Kinase A-Anchoring Protein 3 3 4
  • Fibrousheathin I 3 4
  • Fibrousheathin-1 3 4
  • AKAP 110 3 4
  • AKAP110 3 4
  • FSP95 3 4
  • PRKA3 3 4
  • CT82 3 4
  • SOB1 3 4
  • Protein Kinase A Binding Protein AKAP 110 3
  • A-Kinase Anchor Protein, 110kDa 3
  • A-Kinase Anchor Protein 110 KDa 4
  • Epididymis Luminal Protein 159 3
  • Sperm Oocyte-Binding Protein 1 3
  • Sperm Oocyte-Binding Protein 4
  • A-Kinase Anchor Protein 3 3
  • HEL159 3
  • AKAP-3 4

External Ids for AKAP3 Gene

Summaries for AKAP3 Gene

Entrez Gene Summary for AKAP3 Gene

  • This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013]

GeneCards Summary for AKAP3 Gene

AKAP3 (A Kinase (PRKA) Anchor Protein 3) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein kinase A binding. An important paralog of this gene is AKAP4.

UniProtKB/Swiss-Prot for AKAP3 Gene

  • May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction

Gene Wiki entry for AKAP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP3 Gene

Genomics for AKAP3 Gene

Genomic Location for AKAP3 Gene

Start:
4,614,671 bp from pter
End:
4,649,047 bp from pter
Size:
34,377 bases
Orientation:
Minus strand

Genomic View for AKAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP3 Gene

Regulatory Elements for AKAP3 Gene

Proteins for AKAP3 Gene

  • Protein details for AKAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75969-AKAP3_HUMAN
    Recommended name:
    A-kinase anchor protein 3
    Protein Accession:
    O75969
    Secondary Accessions:
    • O75945
    • Q86X01
    • Q9UM61

    Protein attributes for AKAP3 Gene

    Size:
    853 amino acids
    Molecular mass:
    94751 Da
    Quaternary structure:
    • Interacts with ROPN1 AND ROPN1L.

neXtProt entry for AKAP3 Gene

Proteomics data for AKAP3 Gene at MOPED

Post-translational modifications for AKAP3 Gene

Other Protein References for AKAP3 Gene

No data available for DME Specific Peptides for AKAP3 Gene

Domains for AKAP3 Gene

Gene Families for AKAP3 Gene

HGNC:
  • AKAP :A-kinase anchor proteins

Protein Domains for AKAP3 Gene

UniProtKB/Swiss-Prot:

AKAP3_HUMAN
Domain:
  • RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer:
    • O75969
Family:
  • Belongs to the AKAP110 family.:
    • O75969
genes like me logo Genes that share domains with AKAP3: view

Function for AKAP3 Gene

Molecular function for AKAP3 Gene

GENATLAS Biochemistry: A kinase (PRKA regulatory subunit RIIA) anchor protein 3,may be involved in oocyte recognition,sperm-oocyte binding protein
UniProtKB/Swiss-Prot Function: May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction

Gene Ontology (GO) - Molecular Function for AKAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11278869
GO:0051018 protein kinase A binding IEA --
genes like me logo Genes that share ontologies with AKAP3: view

Phenotypes for AKAP3 Gene

GenomeRNAi human phenotypes for AKAP3:
genes like me logo Genes that share phenotypes with AKAP3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AKAP3 Gene

Localization for AKAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP3 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP3 Gene COMPARTMENTS Subcellular localization image for AKAP3 gene
Compartment Confidence
cytosol 3
nucleus 3
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AKAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IBA --
GO:0031514 motile cilium --
GO:0035686 sperm fibrous sheath IBA --
genes like me logo Genes that share ontologies with AKAP3: view

Pathways for AKAP3 Gene

genes like me logo Genes that share pathways with AKAP3: view

Pathways by source for AKAP3 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for AKAP3 Gene
1 BioSystems pathway for AKAP3 Gene

Gene Ontology (GO) - Biological Process for AKAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 10319321
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA --
GO:0007338 single fertilization TAS 10319321
GO:0007340 acrosome reaction TAS 10319321
GO:0008104 protein localization IEA --
genes like me logo Genes that share ontologies with AKAP3: view

Compounds for AKAP3 Gene

(1) Novoseek inferred chemical compound relationships for AKAP3 Gene

Compound -log(P) Hits PubMed IDs
sp(1-7) 90.2 8
genes like me logo Genes that share compounds with AKAP3: view

Transcripts for AKAP3 Gene

Unigene Clusters for AKAP3 Gene

A kinase (PRKA) anchor protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5
SP1: -
SP2:
SP3: - -

Relevant External Links for AKAP3 Gene

GeneLoc Exon Structure for
AKAP3
ECgene alternative splicing isoforms for
AKAP3

Expression for AKAP3 Gene

mRNA expression in normal human tissues for AKAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AKAP3 Gene

This gene is overexpressed in Testis (36.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AKAP3 Gene

SOURCE GeneReport for Unigene cluster for AKAP3 Gene Hs.98397

mRNA Expression by UniProt/SwissProt for AKAP3 Gene

O75969-AKAP3_HUMAN
Tissue specificity: Testis specific; only expressed in spermatids
genes like me logo Genes that share expressions with AKAP3: view

Orthologs for AKAP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKAP3 36
  • 98.67 (n)
  • 98.01 (a)
AKAP3 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AKAP3 36
  • 80.22 (n)
  • 76.83 (a)
AKAP3 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKAP3 36
  • 85.95 (n)
  • 81.22 (a)
AKAP3 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akap3 36
  • 78.91 (n)
  • 75.24 (a)
Akap3 16
Akap3 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AKAP3 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akap3 36
  • 79.42 (n)
  • 75.95 (a)
lizard
(Anolis carolinensis)
Reptilia AKAP3 37
  • 38 (a)
OneToOne
Species with no ortholog for AKAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AKAP3 Gene

ENSEMBL:
Gene Tree for AKAP3 (if available)
TreeFam:
Gene Tree for AKAP3 (if available)

Paralogs for AKAP3 Gene

Paralogs for AKAP3 Gene

genes like me logo Genes that share paralogs with AKAP3: view

Variants for AKAP3 Gene

Sequence variations from dbSNP and Humsavar for AKAP3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs720672 -- 4,614,785(-) GCTTC(A/G)ATGAC utr-variant-3-prime
rs720673 -- 4,614,503(-) TTACT(A/T)AGCTT downstream-variant-500B
rs876586 -- 4,635,652(-) CAAAA(A/T)ATTGG intron-variant
rs887307 -- 4,633,906(-) ATGAT(G/T)ATTTG intron-variant
rs917565 -- 4,629,160(-) GGGCT(A/G)TGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKAP3 Gene

Variant ID Type Subtype PubMed ID
nsv832318 CNV Gain 17160897
nsv7226 OTHER Inversion 18451855
dgv1346n71 CNV Loss 21882294
nsv468986 CNV Loss 19166990
esv2745449 CNV Deletion 23290073
dgv1347n71 CNV Loss 21882294
nsv826200 CNV Gain 20364138
esv1007580 CNV Insertion 20482838
esv267844 CNV Insertion 20981092
nsv587 CNV Insertion 18451855
dgv1348n71 CNV Loss 21882294

Relevant External Links for AKAP3 Gene

HapMap Linkage Disequilibrium report
AKAP3

Disorders for AKAP3 Gene

(2) Novoseek inferred disease relationships for AKAP3 Gene

Disease -log(P) Hits PubMed IDs
ovarian cancer 33 2
tumors 3.56 2
genes like me logo Genes that share disorders with AKAP3: view

No data available for UniProtKB/Swiss-Prot for AKAP3 Gene

Publications for AKAP3 Gene

  1. Isolation and molecular characterization of AKAP110, a novel, sperm- specific protein kinase A-anchoring protein. (PMID: 10319321) Vijayaraghavan S. … Carr D.W. (Mol. Endocrinol. 1999) 2 3 4 23
  2. FSP95, a testis-specific 95-kilodalton fibrous sheath antigen that undergoes tyrosine phosphorylation in capacitated human spermatozoa. (PMID: 10529264) Mandal A. … Herr J.C. (Biol. Reprod. 1999) 3 4 23
  3. Cloning and characterization of SOB1, a new testis-specific cDNA encoding a human sperm protein probably involved in oocyte recognition. (PMID: 10334916) Lefevre A. … Finaz C. (Biochem. Biophys. Res. Commun. 1999) 2 3 4
  4. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. (PMID: 11278869) Carr D.W. … Narumiya S. (J. Biol. Chem. 2001) 3 4
  5. A-kinase anchoring protein 3 messenger RNA expression in ovarian cancer and its implication on prognosis. (PMID: 14618620) Hasegawa K. … Nakayama E. (Int. J. Cancer 2004) 3 23

Products for AKAP3 Gene

Sources for AKAP3 Gene

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