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Aliases for AKAP3 Gene

Aliases for AKAP3 Gene

  • A-Kinase Anchoring Protein 3 2 3 5
  • Fibrous Sheath Protein Of 95 KDa 2 3 4
  • Cancer/Testis Antigen 82 2 3 4
  • Protein Kinase A-Anchoring Protein 3 3 4
  • A Kinase (PRKA) Anchor Protein 3 2 3
  • Fibrousheathin I 3 4
  • Fibrousheathin-1 3 4
  • AKAP 110 3 4
  • AKAP110 3 4
  • FSP95 3 4
  • PRKA3 3 4
  • CT82 3 4
  • SOB1 3 4
  • Protein Kinase A Binding Protein AKAP 110 3
  • A-Kinase Anchor Protein, 110kDa 3
  • A-Kinase Anchor Protein 110 KDa 4
  • Epididymis Luminal Protein 159 3
  • Sperm Oocyte-Binding Protein 1 3
  • Sperm Oocyte-Binding Protein 4
  • HEL159 3
  • AKAP-3 4

External Ids for AKAP3 Gene

Previous GeneCards Identifiers for AKAP3 Gene

  • GC12M004462
  • GC12M004617
  • GC12M004594
  • GC12M004724

Summaries for AKAP3 Gene

Entrez Gene Summary for AKAP3 Gene

  • This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013]

GeneCards Summary for AKAP3 Gene

AKAP3 (A-Kinase Anchoring Protein 3) is a Protein Coding gene. Among its related pathways are G Protein Signaling Pathways and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein kinase A binding. An important paralog of this gene is AKAP4.

UniProtKB/Swiss-Prot for AKAP3 Gene

  • May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.

Gene Wiki entry for AKAP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP3 Gene

Genomics for AKAP3 Gene

Regulatory Elements for AKAP3 Gene

Promoters for AKAP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AKAP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for AKAP3 Gene

Chromosome:
12
Start:
4,615,508 bp from pter
End:
4,649,047 bp from pter
Size:
33,540 bases
Orientation:
Minus strand

Genomic View for AKAP3 Gene

Genes around AKAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP3 Gene

Proteins for AKAP3 Gene

  • Protein details for AKAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75969-AKAP3_HUMAN
    Recommended name:
    A-kinase anchor protein 3
    Protein Accession:
    O75969
    Secondary Accessions:
    • O75945
    • Q86X01
    • Q9UM61

    Protein attributes for AKAP3 Gene

    Size:
    853 amino acids
    Molecular mass:
    94751 Da
    Quaternary structure:
    • Interacts with ROPN1 AND ROPN1L.

neXtProt entry for AKAP3 Gene

Proteomics data for AKAP3 Gene at MOPED

Post-translational modifications for AKAP3 Gene

Other Protein References for AKAP3 Gene

Antibody Products

No data available for DME Specific Peptides for AKAP3 Gene

Domains & Families for AKAP3 Gene

Gene Families for AKAP3 Gene

Protein Domains for AKAP3 Gene

Suggested Antigen Peptide Sequences for AKAP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75969

UniProtKB/Swiss-Prot:

AKAP3_HUMAN :
  • RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
  • Belongs to the AKAP110 family.
Domain:
  • RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Family:
  • Belongs to the AKAP110 family.
genes like me logo Genes that share domains with AKAP3: view

Function for AKAP3 Gene

Molecular function for AKAP3 Gene

GENATLAS Biochemistry:
A kinase (PRKA regulatory subunit RIIA) anchor protein 3,may be involved in oocyte recognition,sperm-oocyte binding protein
UniProtKB/Swiss-Prot Function:
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.

Gene Ontology (GO) - Molecular Function for AKAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051018 protein kinase A binding IEA --
genes like me logo Genes that share ontologies with AKAP3: view
genes like me logo Genes that share phenotypes with AKAP3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AKAP3 Gene

Localization for AKAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP3 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP3 Gene COMPARTMENTS Subcellular localization image for AKAP3 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for AKAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with AKAP3: view

Pathways & Interactions for AKAP3 Gene

genes like me logo Genes that share pathways with AKAP3: view

Pathways by source for AKAP3 Gene

1 BioSystems pathway for AKAP3 Gene
1 GeneGo (Thomson Reuters) pathway for AKAP3 Gene

Gene Ontology (GO) - Biological Process for AKAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA --
GO:0007338 single fertilization TAS 10319321
genes like me logo Genes that share ontologies with AKAP3: view

No data available for SIGNOR curated interactions for AKAP3 Gene

Drugs & Compounds for AKAP3 Gene

(1) Additional Compounds for AKAP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with AKAP3: view

Transcripts for AKAP3 Gene

Unigene Clusters for AKAP3 Gene

A kinase (PRKA) anchor protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5
SP1: -
SP2:
SP3: - -

Relevant External Links for AKAP3 Gene

GeneLoc Exon Structure for
AKAP3
ECgene alternative splicing isoforms for
AKAP3

Expression for AKAP3 Gene

mRNA expression in normal human tissues for AKAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AKAP3 Gene

This gene is overexpressed in Testis (x36.0).

Protein differential expression in normal tissues from HIPED for AKAP3 Gene

This gene is overexpressed in Ovary (38.5) and Testis (29.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AKAP3 Gene



SOURCE GeneReport for Unigene cluster for AKAP3 Gene Hs.98397

mRNA Expression by UniProt/SwissProt for AKAP3 Gene

O75969-AKAP3_HUMAN
Tissue specificity: Testis specific; only expressed in spermatids.
genes like me logo Genes that share expression patterns with AKAP3: view

Protein tissue co-expression partners for AKAP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for AKAP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKAP3 35
  • 98.67 (n)
  • 98.01 (a)
AKAP3 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AKAP3 36
  • 75 (a)
OneToOne
AKAP3 35
  • 80.22 (n)
  • 76.83 (a)
dog
(Canis familiaris)
Mammalia AKAP3 35
  • 85.95 (n)
  • 81.22 (a)
AKAP3 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akap3 16
Akap3 36
  • 73 (a)
OneToOne
Akap3 35
  • 78.91 (n)
  • 75.24 (a)
oppossum
(Monodelphis domestica)
Mammalia AKAP3 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akap3 35
  • 79.42 (n)
  • 75.95 (a)
lizard
(Anolis carolinensis)
Reptilia AKAP3 36
  • 38 (a)
OneToOne
Species with no ortholog for AKAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AKAP3 Gene

ENSEMBL:
Gene Tree for AKAP3 (if available)
TreeFam:
Gene Tree for AKAP3 (if available)

Paralogs for AKAP3 Gene

Paralogs for AKAP3 Gene

genes like me logo Genes that share paralogs with AKAP3: view

Variants for AKAP3 Gene

Sequence variations from dbSNP and Humsavar for AKAP3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_036428 A colorectal cancer sample
rs2072355 - 4,628,549(-) CAACG(A/G)GAGTT reference, missense
rs12366671 - 4,627,403(+) TGCCA(A/G)TATCT reference, missense
rs1990313 - 4,626,920(-) CCAGA(C/T)AGATG reference, missense
rs2041291 - 4,626,803(-) CAAGT(C/T)TGGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for AKAP3 Gene

Variant ID Type Subtype PubMed ID
nsv832318 CNV Gain 17160897
nsv7226 OTHER Inversion 18451855
dgv1346n71 CNV Loss 21882294
nsv468986 CNV Loss 19166990
esv2745449 CNV Deletion 23290073
dgv1347n71 CNV Loss 21882294
nsv826200 CNV Gain 20364138
esv1007580 CNV Insertion 20482838
esv267844 CNV Insertion 20981092
nsv587 CNV Insertion 18451855
dgv1348n71 CNV Loss 21882294

Variation tolerance for AKAP3 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.73; 86.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKAP3 Gene

HapMap Linkage Disequilibrium report
AKAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP3 Gene

Disorders for AKAP3 Gene

Relevant External Links for AKAP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKAP3

No disorders were found for AKAP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKAP3 Gene

Publications for AKAP3 Gene

  1. Isolation and molecular characterization of AKAP110, a novel, sperm- specific protein kinase A-anchoring protein. (PMID: 10319321) Vijayaraghavan S. … Carr D.W. (Mol. Endocrinol. 1999) 2 3 4 23 67
  2. A-kinase anchoring protein 3 messenger RNA expression correlates with poor prognosis in epithelial ovarian cancer. (PMID: 16005946) Sharma S. … Odunsi K. (Gynecol. Oncol. 2005) 3 23
  3. Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. (PMID: 15257753) Lea I.A. … O'Rand M.G. (Reprod. Biol. Endocrinol. 2004) 3 23
  4. A-kinase anchoring protein 3 messenger RNA expression in ovarian cancer and its implication on prognosis. (PMID: 14618620) Hasegawa K. … Nakayama E. (Int. J. Cancer 2004) 3 23
  5. FSP95, a testis-specific 95-kilodalton fibrous sheath antigen that undergoes tyrosine phosphorylation in capacitated human spermatozoa. (PMID: 10529264) Mandal A. … Herr J.C. (Biol. Reprod. 1999) 3 23

Products for AKAP3 Gene

Sources for AKAP3 Gene

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