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AKAP3 Gene

protein-coding   GIFtS: 56
GCID: GC12M004724

A Kinase (PRKA) Anchor Protein 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
A Kinase (PRKA) Anchor Protein 31 2     HEL1592
Cancer/Testis Antigen 821 2 3     A-Kinase Anchor Protein 32
Fibrous Sheath Protein Of 95 KDa1 2 3     A-Kinase Anchor Protein, 110kDa2
Fibrousheathin I2 3     Epididymis Luminal Protein 1592
Protein Kinase A-Anchoring Protein 32 3     fibrousheathin-12
AKAP1102 3     Protein Kinase A Binding Protein AKAP 1102
CT822 3     Sperm Oocyte-Binding Protein 12
FSP952 3     AKAP-33
PRKA32 3     Fibrousheathin-13
SOB12 3     A-Kinase Anchor Protein 110 KDa3
AKAP 1102 3     Sperm Oocyte-Binding Protein3

External Ids:    HGNC: 3731   Entrez Gene: 105662   Ensembl: ENSG000001112547   OMIM: 6046895   UniProtKB: O759693   

Export aliases for AKAP3 gene to outside databases

Previous GC identifers: GC12M004462 GC12M004617 GC12M004594


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AKAP3 Gene:
This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that
target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in
protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins.
This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the
length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome
reaction. (provided by RefSeq, May 2013)

GeneCards Summary for AKAP3 Gene:
AKAP3 (A kinase (PRKA) anchor protein 3) is a protein-coding gene. GO annotations related to this gene include protein kinase A binding. An important paralog of this gene is AKAP4.

UniProtKB/Swiss-Prot: AKAP3_HUMAN, O75969
Function: May function as a regulator of both motility- and head-associated functions such as capacitation and the
acrosome reaction

Gene Wiki entry for AKAP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AKAP3 gene promoter:
         RFX1   AML1a   GATA-3   FOXD1   POU6F1 (c2)   STAT5A   E4BP4   Arnt   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAKAP3 promoter sequence
   Search Chromatin IP Primers for AKAP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKAP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.32   HGNC cytogenetic band: 12p13.3

AKAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKAP3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M004724:  view genomic region     (about GC identifiers)

Start:
4,724,674 bp from pter      End:
4,758,213 bp from pter
Size:
33,540 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AKAP3_HUMAN, O75969 (See protein sequence)
Recommended Name: A-kinase anchor protein 3  
Size: 853 amino acids; 94751 Da
Subunit: Interacts with ROPN1 AND ROPN1L
Secondary accessions: O75945 Q86X01 Q9UM61

Explore the universe of human proteins at neXtProt for AKAP3: NX_O75969

Explore proteomics data for AKAP3 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AKAP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265238.1  NP_006413.3  

    ENSEMBL proteins: 
     ENSP00000440994   ENSP00000442376   ENSP00000439382   ENSP00000228850  

    AKAP3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AKAP: A-kinase anchor proteins

    4 InterPro protein domains:
     IPR020799 AKAP_110
     IPR018292 AKAP_110_C
     IPR008382 SPHK1-interactor_AKAP_110
     IPR018459 RII_binding_1

    Graphical View of Domain Structure for InterPro Entry O75969

    ProtoNet protein and cluster: O75969

    1 Blocks protein domain: IPB008382 A-kinase anchor 110 kDa

    UniProtKB/Swiss-Prot: AKAP3_HUMAN, O75969
    Domain: RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein
    interactions with a complementary surface on the R-subunit dimer
    Similarity: Belongs to the AKAP110 family


    Find genes that share domains with AKAP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKAP3_HUMAN, O75969
    Function: May function as a regulator of both motility- and head-associated functions such as capacitation and the
    acrosome reaction

         Genatlas biochemistry entry for AKAP3:
    A kinase (PRKA regulatory subunit RIIA) anchor protein 3,may be involved in oocyte recognition,sperm-oocyte
    binding protein

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11278869
    GO:0051018protein kinase A binding IEA--
         
    Find genes that share ontologies with AKAP3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AKAP3:
     Increased apoptosis 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for AKAP3

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    6 qRT-PCR Assays for microRNAs that regulate AKAP3:
    hsa-miR-502-5p hsa-miR-199a-5p hsa-miR-2276 hsa-miR-199b-5p hsa-miR-590-3p hsa-miR-1825
    SwitchGear 3'UTR luciferase reporter plasmidAKAP3 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AKAP3_HUMAN, O75969: Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Note=Ribs of the fibrous
    sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0031514motile cilium IEA--

    Find genes that share ontologies with AKAP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AKAP3 About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    3Signal transduction PKA signaling
    Signal transduction PKA signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AKAP3
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 GeneGo (Thomson Reuters) Pathway for AKAP3
        Signal transduction PKA signaling

    1 BioSystems Pathway for AKAP3
        G Protein Signaling Pathways


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AKAP3
    Interactions:

        GeneGlobe Interaction Network for AKAP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for AKAP3 (O759693 ENSP000002288504) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAR2AP138613, ENSP000002655634I2D: score=3 STRING: ENSP00000265563
    ROPN1Q9HAT03, ENSP000001841834I2D: score=2 STRING: ENSP00000184183
    ROPN1LQ96C743, ENSP000002741344I2D: score=2 STRING: ENSP00000274134
    ROPN1BQ9BZX43, ENSP000002517764I2D: score=1 STRING: ENSP00000251776
    GNA13Q143443, ENSP000004007174I2D: score=3 STRING: ENSP00000400717
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    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement IEA--
    GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway IEA--
    GO:0007338single fertilization TAS10319321
    GO:0007340acrosome reaction TAS10319321
    GO:0008104protein localization IEA--

    Find genes that share ontologies with AKAP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AKAP3

    1 Novoseek inferred chemical compound relationship for AKAP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sp(1-7) 90.2 13 15257753 (7), 17551920 (1)



    Find genes that share compounds with AKAP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AKAP3 gene (2 alternative transcripts): 
    NM_001278309.1  NM_006422.3  

    Unigene Cluster for AKAP3:

    A kinase (PRKA) anchor protein 3
    Hs.98397  [show with all ESTs]
    Unigene Representative Sequence: AK292451
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000545990 ENST00000540967 ENST00000536414 ENST00000541484 ENST00000544636
    ENST00000228850(uc001qnb.4)
    miRNA
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    hsa-miR-502-5p hsa-miR-199a-5p hsa-miR-2276 hsa-miR-199b-5p hsa-miR-590-3p hsa-miR-1825
    SwitchGear 3'UTR luciferase reporter plasmidAKAP3 3' UTR sequence
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    Additional mRNA sequence: 

    AF087003.1 AF093408.1 AK074722.1 AK292451.1 BC047535.1 U85715.1 

    5 DOTS entries:

    DT.121205621  DT.410289  DT.121205619  DT.100710834  DT.121205640 

    Selected AceView cDNA sequences (see all 32):

    AL045409 AA437255 NM_006422 AI138771 AI217917 AL079520 BG772484 AI028271 
    U85715 BI459865 BC047535 BV173748 BM702548 BG772320 AI081873 AF093408 
    AK074722 AI143878 AF087003 BM665261 AA626349 BG188100 BX110710 AA781821 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for AKAP3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5
    SP1:                    -                                       
    SP2:                                                            
    SP3:                    -     -                                 


    ECgene alternative splicing isoforms for AKAP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AKAP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGCAAGGA
    AKAP3 Expression
    About this image


    AKAP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
    AKAP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKAP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98397

    UniProtKB/Swiss-Prot: AKAP3_HUMAN, O75969
    Tissue specificity: Testis specific; only expressed in spermatids

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AKAP3 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akap31 , 5 A kinase (PRKA) anchor protein 31, 5 78.91(n)1
    75.24(a)1
      6 (61.92 cM)5
    116421  NM_009650.21  NP_033780.21 
     1268530985 
    lizard
    (Anolis carolinensis)
    Reptilia AKAP36
    A kinase (PRKA) anchor protein 3
    38(a)
    1 ↔ 1
    5(80890592-80903611)


    ENSEMBL Gene Tree for AKAP3 (if available)
    TreeFam Gene Tree for AKAP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AKAP3 gene
    AKAP42  

    Find genes that share paralogs with AKAP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AKAP3 (see all 803)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364284
    A colorectal cancer sample4--see VAR_0364282 R C mis40--------
    rs30837271,2
    C--4583627(+) AAAAA-/A/A   
       A
    /AAA
    GTGTT
    2 -- int1 cds1 trp30--------
    rs3763843491,2
    --4675327(+) CCATT-/AAAAAAA 1 -- int10--------
    rs1865531541,2
    --4724226(+) GCAGTA/GTTAGA 1 -- ds50010--------
    rs1119907831,2
    C,F--4724228(+) AGTGTC/TAGAAC 1 -- ds50012Minor allele frequency- T:0.00CSA 2
    rs1914737651,2
    --4724290(+) AACTCA/GGATCC 1 -- ds50010--------
    rs1828061261,2
    --4724414(+) TTTGAC/TTGAAT 1 -- ds50010--------
    rs118308261,2
    C,F,A,H--4724588(+) CTGTTG/ATACCT 1 -- ds50015Minor allele frequency- A:0.00NS EA NA 422
    rs801774351,2
    F--4724668(+) GAAACA/GAAACA 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1439356981,2
    --4724831(+) AGATGA/TGGAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for AKAP3 (4724674 - 4758213 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AKAP3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745449CNV Deletion23290073
    esv1007580CNV Insertion20482838
    esv267844CNV Insertion20981092
    nsv587CNV Insertion18451855
    nsv468986CNV Loss19166990
    dgv1346n71CNV Loss21882294
    dgv1348n71CNV Loss21882294
    dgv1347n71CNV Loss21882294
    nsv826200CNV Gain20364138
    nsv832318CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AKAP3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604689    OMIM disorders: --


    Find genes that share disorders with AKAP3           About GenesLikeMe

    2 Novoseek inferred disease relationships for AKAP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 33 2 14618620 (1), 16005946 (1)
    tumors 3.56 2 14618620 (2)


    Export disorders for AKAP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AKAP3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with AKAP3)
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    1. Isolation and molecular characterization of AKAP110, a novel, sperm- specific protein kinase A-anchoring protein. (PubMed id 10319321)1, 2, 3, 9 Vijayaraghavan S....Carr D.W. (Mol. Endocrinol. 1999)
    2. Cloning and characterization of SOB1, a new testis-specific cDNA encoding a human sperm protein probably involved in oocyte recognition. (PubMed id 10334916)1, 2, 3 Lefevre A.... Finaz C. (Biochem. Biophys. Res. Commun. 1999)
    3. FSP95, a testis-specific 95-kilodalton fibrous sheath antigen that undergoes tyrosine phosphorylation in capacitated human spermatozoa. (PubMed id 10529264)1, 2, 9 Mandal A.... Herr J.C. (Biol. Reprod. 1999)
    4. Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin- containing protein/p97 during capacitation. (PubMed id 12509440)1, 2 Ficarro S....Visconti P.E. (J. Biol. Chem. 2003)
    5. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. (PubMed id 11278869)1, 2 Carr D.W....Narumiya S. (J. Biol. Chem. 2001)
    6. Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. (PubMed id 15257753)1, 9 Lea I.A....O'Rand M.G. (amp 2004)
    7. A-kinase anchoring protein 3 messenger RNA expression correlates with poor prognosis in epithelial ovarian cancer. (PubMed id 16005946)1, 9 Sharma S....Odunsi K. (Gynecol. Oncol. 2005)
    8. A-kinase anchoring protein 3 messenger RNA expression in ovarian cancer and its implication on prognosis. (PubMed id 14618620)1, 9 Hasegawa K....Nakayama E. (Int. J. Cancer 2004)
    9. Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. (PubMed id 23077236)1 Vigodner M....Callaway M. (Hum. Reprod. 2013)
    10. Identification of the cancer/testis antigens AKAP3 and CTp11 by SEREX in hepatocellular carcinoma. (PubMed id 22941507)1 Song M.H....Lee S.Y. (Oncol. Rep. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10566 HGNC: 373 AceView: AKAP3 Ensembl:ENSG00000111254 euGenes: HUgn10566
    ECgene: AKAP3 H-InvDB: AKAP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AKAP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AKAP3 gene:
    Search GeneIP for patents involving AKAP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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