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Aliases for AKAP2 Gene

Aliases for AKAP2 Gene

  • A Kinase (PRKA) Anchor Protein 2 2 3
  • Protein Kinase A2 2 3
  • KIAA0920 4 6
  • AKAPKL 3 6
  • AKAP-2 3 4
  • PRKA2 3 4
  • Protein Kinase A Anchoring Protein 2 3
  • Protein Kinase A-Anchoring Protein 2 4
  • A-Kinase Anchor Protein 2 3
  • AKAP-KL 4
  • PALM2 6

External Ids for AKAP2 Gene

Previous Symbols for AKAP2 Gene

  • PRKA2

Summaries for AKAP2 Gene

Entrez Gene Summary for AKAP2 Gene

  • The protein encoded by this gene binds to the regulatory subunit of protein kinase A and is found associated with the actin cytoskeleton. The encoded protein mediates signals carried by cAMP and may be involved in creating polarity in certain signaling processes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for AKAP2 Gene

AKAP2 (A Kinase (PRKA) Anchor Protein 2) is a Protein Coding gene. Among its related pathways are G Protein Signaling Pathways and Signal transduction_PKA signaling. GO annotations related to this gene include enzyme binding. An important paralog of this gene is PALMD.

UniProtKB/Swiss-Prot for AKAP2 Gene

  • Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity).

Gene Wiki entry for AKAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP2 Gene

Genomics for AKAP2 Gene

Genomic Location for AKAP2 Gene

Start:
110,048,598 bp from pter
End:
110,172,512 bp from pter
Size:
123,915 bases
Orientation:
Plus strand

Genomic View for AKAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP2 Gene

Regulatory Elements for AKAP2 Gene

Proteins for AKAP2 Gene

  • Protein details for AKAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2D5-AKAP2_HUMAN
    Recommended name:
    A-kinase anchor protein 2
    Protein Accession:
    Q9Y2D5
    Secondary Accessions:
    • B1ALX9
    • B2RTU4
    • B3KQ00
    • B4DTZ2
    • B7ZW07
    • B9EJB5
    • Q9UG26

    Protein attributes for AKAP2 Gene

    Size:
    859 amino acids
    Molecular mass:
    94661 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76764.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AKAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKAP2 Gene

Proteomics data for AKAP2 Gene at MOPED

Post-translational modifications for AKAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKAP2 Gene

No data available for DME Specific Peptides for AKAP2 Gene

Domains for AKAP2 Gene

Gene Families for AKAP2 Gene

HGNC:
  • AKAP :A-kinase anchor proteins

Protein Domains for AKAP2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

AKAP2_HUMAN
Domain:
  • The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer:
    • Q9Y2D5
genes like me logo Genes that share domains with AKAP2: view

Function for AKAP2 Gene

Molecular function for AKAP2 Gene

GENATLAS Biochemistry: A kinase,scaffold protein (PRKA regulatory subunit RIIA) anchor protein 2
UniProtKB/Swiss-Prot Function: Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity).

miRNA for AKAP2 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AKAP2 Gene

Localization for AKAP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP2 Gene COMPARTMENTS Subcellular localization image for AKAP2 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for AKAP2 Gene

Pathways for AKAP2 Gene

genes like me logo Genes that share pathways with AKAP2: view

Pathways by source for AKAP2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for AKAP2 Gene
1 BioSystems pathway for AKAP2 Gene
1 PharmGKB pathway for AKAP2 Gene

Interacting Proteins for AKAP2 Gene

Gene Ontology (GO) - Biological Process for AKAP2 Gene

None

Compounds for AKAP2 Gene

(1) HMDB Compounds for AKAP2 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4
genes like me logo Genes that share compounds with AKAP2: view

Transcripts for AKAP2 Gene

Unigene Clusters for AKAP2 Gene

A kinase (PRKA) anchor protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP2 Gene

No ASD Table

Relevant External Links for AKAP2 Gene

GeneLoc Exon Structure for
AKAP2
ECgene alternative splicing isoforms for
AKAP2

Expression for AKAP2 Gene

mRNA expression in normal human tissues for AKAP2 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for AKAP2 Gene

SOURCE GeneReport for Unigene cluster for AKAP2 Gene Hs.591908

genes like me logo Genes that share expressions with AKAP2: view

Orthologs for AKAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 96 (a)
ManyToMany
AKAP2 36
  • 99.02 (n)
  • 98.95 (a)
PALM2 37
  • 38 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 37
  • 88 (a)
ManyToMany
PALM2 37
  • 37 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia PALM2 37
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Akap2 36
  • 83.41 (n)
  • 85.4 (a)
Akap2 16
Gm20459 37
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia AKAP2 37
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia AKAP2 37
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Akap2 36
  • 83.63 (n)
  • 85.41 (a)
chicken
(Gallus gallus)
Aves AKAP2 36
  • 67.35 (n)
  • 65.78 (a)
AKAP2 37
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 63 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.2612 36
tropical clawed frog
(Silurana tropicalis)
Amphibia akap2 36
  • 56.92 (n)
  • 53.12 (a)
Str.15035 36
zebrafish
(Danio rerio)
Actinopterygii akap2 36
  • 57.39 (n)
  • 53.37 (a)
palm2 37
  • 39 (a)
OneToMany
Species with no ortholog for AKAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKAP2 Gene

ENSEMBL:
Gene Tree for AKAP2 (if available)
TreeFam:
Gene Tree for AKAP2 (if available)

Paralogs for AKAP2 Gene

Paralogs for AKAP2 Gene

genes like me logo Genes that share paralogs with AKAP2: view

Variants for AKAP2 Gene

Sequence variations from dbSNP and Humsavar for AKAP2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
VAR_024248 -

Structural Variations from Database of Genomic Variants (DGV) for AKAP2 Gene

Variant ID Type Subtype PubMed ID
dgv494n21 CNV Gain 19592680
nsv893711 CNV Gain 21882294
nsv471314 CNV Loss 18288195
esv2619523 CNV Deletion 19546169
esv2096560 CNV Deletion 18987734
esv2672512 CNV Deletion 23128226
esv2501710 CNV Deletion 19546169
esv2195369 CNV Deletion 18987734
esv2658904 CNV Deletion 23128226
esv28884 CNV Loss 19812545
nsv466480 CNV Loss 19166990
esv2738920 CNV Deletion 23290073
esv273365 CNV Insertion 20981092
nsv466481 CNV Gain 19166990
nsv471316 CNV Gain 18288195
nsv515562 CNV Gain 19592680
nsv524745 CNV Gain 19592680
esv2752274 CNV Gain 17911159

Relevant External Links for AKAP2 Gene

HapMap Linkage Disequilibrium report
AKAP2
Human Gene Mutation Database (HGMD)
AKAP2

Disorders for AKAP2 Gene

Relevant External Links for AKAP2

Genetic Association Database (GAD)
AKAP2
Human Genome Epidemiology (HuGE) Navigator
AKAP2
genes like me logo Genes that share disorders with AKAP2: view

No data available for UniProtKB/Swiss-Prot for AKAP2 Gene

Publications for AKAP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative. (PMID: 11478809) Hu B. … Kilimann M.W. (Biochem. Biophys. Res. Commun. 2001) 3 4
  5. Replication of a genome-wide case-control study of esophageal squamous cell carcinoma. (PMID: 18649358) Ng D. … Taylor P.R. (Int. J. Cancer 2008) 3 49

Products for AKAP2 Gene

Sources for AKAP2 Gene

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