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AKAP2 Gene

protein-coding   GIFtS: 56
GCID: GC09P112543

A Kinase (PRKA) Anchor Protein 2


(Previous symbol: PRKA2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
A Kinase (PRKA) Anchor Protein 21 2     A-Kinase Anchor Protein 22
PRKA21 2 3     Protein Kinase A Anchoring Protein 22
Protein Kinase A21 2     AKAP-KL3
AKAP-22 3     Protein Kinase A-Anchoring Protein 23
AKAPKL2 5     PALM25
KIAA09203 5     

External Ids:    HGNC: 3721   Entrez Gene: 112172   Ensembl: ENSG000002419787   OMIM: 6045825   UniProtKB: Q9Y2D53   

Export aliases for AKAP2 gene to outside databases

Previous GC identifers: GC09P103340 GC09P104135 GC09U900391 GC09P107923 GC09P107924 GC09P109623 GC09P111442 GC09P111850 GC09P112810 GC09P082413


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AKAP2 Gene:
The protein encoded by this gene binds to the regulatory subunit of protein kinase A and is found associated with
the actin cytoskeleton. The encoded protein mediates signals carried by cAMP and may be involved in creating
polarity in certain signaling processes. Three transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Mar 2011)

GeneCards Summary for AKAP2 Gene:
AKAP2 (A kinase (PRKA) anchor protein 2) is a protein-coding gene. Diseases associated with AKAP2 include exfoliation syndrome, and kallmann syndrome. GO annotations related to this gene include enzyme binding. An important paralog of this gene is PALMD.

UniProtKB/Swiss-Prot: AKAP2_HUMAN, Q9Y2D5
Function: Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in
signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus
diffuse, trans-cellular signals carried by cAMP (By similarity)

Gene Wiki entry for AKAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the AKAP2 gene promoter:
         ER-alpha   Pax-6   RORalpha2   E47   NRF-2   POU2F1   FOXO4   POU2F1a   IRF-7A   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAKAP2 promoter sequence
   Search Chromatin IP Primers for AKAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.3   Ensembl cytogenetic band:  9q31.3   HGNC cytogenetic band: 9q31.3

AKAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKAP2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P112543:  view genomic region     (about GC identifiers)

Start:
112,542,769 bp from pter      End:
112,934,792 bp from pter
Size:
392,024 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AKAP2_HUMAN, Q9Y2D5 (See protein sequence)
Recommended Name: A-kinase anchor protein 2  
Size: 859 amino acids; 94661 Da
Sequence caution: Sequence=BAA76764.2; Type=Erroneous initiation;
Secondary accessions: B1ALX9 B2RTU4 B3KQ00 B4DTZ2 B7ZW07 B9EJB5 Q9UG26
Alternative splicing: 5 isoforms:  Q9Y2D5-3   Q9Y2D5-4   Q9Y2D5-5   Q9Y2D5-6   Q9Y2D5-7   (Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein)

Explore the universe of human proteins at neXtProt for AKAP2: NX_Q9Y2D5

Explore proteomics data for AKAP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AKAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001004065.2  NP_001130034.1  NP_001185585.1  

    ENSEMBL proteins: 
     ENSP00000404782   ENSP00000363649   ENSP00000419364   ENSP00000419268   ENSP00000259318  
     ENSP00000451476   ENSP00000421522  

    AKAP2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for AKAP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AKAP: A-kinase anchor proteins

    1 InterPro protein domain:
     IPR018459 RII_binding_1

    Graphical View of Domain Structure for InterPro Entry Q9Y2D5

    ProtoNet protein and cluster: Q9Y2D5

    UniProtKB/Swiss-Prot: AKAP2_HUMAN, Q9Y2D5
    Domain: The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein
    interactions with a complementary surface on the R-subunit dimer


    AKAP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKAP2_HUMAN, Q9Y2D5
    Function: Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in
    signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus
    diffuse, trans-cellular signals carried by cAMP (By similarity)

         Genatlas biochemistry entry for AKAP2:
    A kinase,scaffold protein (PRKA regulatory subunit RIIA) anchor protein 2

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019899enzyme binding ----
         
    AKAP2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AKAP2
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    miRNA
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    miRTarBase miRNAs that target AKAP2:
    hsa-mir-98-5p (MIRT027549), hsa-mir-99a-5p (MIRT048649), hsa-mir-769-5p (MIRT039159), hsa-mir-125b-5p (MIRT046035)

    Block miRNA regulation of human, mouse, rat AKAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AKAP2 (see all 92):
    hsa-miR-140-5p hsa-miR-188-5p hsa-miR-200a hsa-miR-134 hsa-miR-3138 hsa-miR-4275 hsa-miR-4325 hsa-miR-3148
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKAP2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----

    AKAP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AKAP2 About    
    See pathways by source

    SuperPathContained pathways About
    1G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    2Signal transduction PKA signaling
    Signal transduction PKA signaling
    3Proton Pump Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for AKAP2
        Signal transduction PKA signaling

    1 BioSystems Pathway for AKAP2
        G Protein Signaling Pathways

    1 PharmGKB Pathway for AKAP2
        Proton Pump Inhibitor Pathway, Pharmacodynamics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AKAP2
    Interactions:

        Search GeneGlobe Interaction Network for AKAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for AKAP2 (Q9Y2D52, 3 ENSP000003636494) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8111667 I2D: score=3 STRING: ENSP00000274335
    PLCG1P191742, 3, ENSP000002440074MINT-8112363 I2D: score=3 STRING: ENSP00000244007
    SRCP129312, 3, ENSP000003509414MINT-8112879 I2D: score=3 STRING: ENSP00000350941
    PRKAR2AP138613, ENSP000002655634I2D: score=3 STRING: ENSP00000265563
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008360regulation of cell shape ----

    AKAP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AKAP2

    1 HMDB Compound for AKAP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AKAP2 gene (3 alternative transcripts): 
    NM_001004065.4  NM_001136562.2  NM_001198656.1  

    Unigene Cluster for AKAP2:

    A kinase (PRKA) anchor protein 2
    Hs.591908  [show with all ESTs]
    Unigene Representative Sequence: NM_053016
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434623 ENST00000374525(uc011lwi.2 uc004bem.3 uc011lwj.2 uc004ben.3)
    ENST00000495980 ENST00000480388(uc010mtw.1) ENST00000259318 ENST00000471798
    ENST00000482335 ENST00000485762 ENST00000555236 ENST00000510514(uc004bel.1)

    miRNA
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    Block miRNA regulation of human, mouse, rat AKAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AKAP2 (see all 92):
    hsa-miR-140-5p hsa-miR-188-5p hsa-miR-200a hsa-miR-134 hsa-miR-3138 hsa-miR-4275 hsa-miR-4325 hsa-miR-3148
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKAP2
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat AKAP2
      QuantiFast Probe-based Assays in human, mouse, rat AKAP2

    Additional mRNA sequence: 

    AJ312216.1 AJ420463.1 AK022693.1 AK057098.1 AK095003.1 AK300427.1 AK304311.1 AK308388.1 
    AL110268.1 BC010513.1 BC039306.1 BC146863.1 BC171800.1 

    22 DOTS entries:

    DT.95224337  DT.100672436  DT.454365  DT.100814438  DT.100714673  DT.307265  DT.121200228  DT.40126257 
    DT.40308274  DT.100016459  DT.86848985  DT.101970470  DT.95089978  DT.100037195  DT.100814437  DT.121200234 
    DT.91952001  DT.100814435  DT.121200364  DT.95293768  DT.100697843  DT.91799761 

    Selected AceView cDNA sequences (see all 299):

    AA806005 BF112229 BU156689 BX112910 AJ714001 N68133 AA419030 AV656593 
    CB110510 AI568078 AA040278 CD676069 CD673966 AI033138 BG027094 N51499 
    NM_007203 AI753746 BU682644 BP340477 CR594891 AW963614 BU619804 AI564315 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AKAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTCACCC
    AKAP2 Expression
    About this image

    AKAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKAP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591908
        Custom PCR Arrays for AKAP2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AKAP2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akap21 , 5 A kinase (PRKA) anchor protein 21, 5 83.41(n)1
    85.4(a)1
      4 (31.79 cM)5
    116411  NM_001035533.21  NP_001030610.11 
     577176575 
    chicken
    (Gallus gallus)
    Aves AKAP21 A kinase (PRKA) anchor protein 2 67.35(n)
    65.78(a)
      100533110  NM_001204217.2  NP_001191146.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    63(a)
    1 → many
    2(57950006-58269436)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.26122 Xenopus laevis transcribed sequence with weak similarity more 75.28(n)    BJ057955.1 
    zebrafish
    (Danio rerio)
    Actinopterygii akap21 A kinase (PRKA) anchor protein 2 57.39(n)
    53.37(a)
      100002543  NM_001204200.1  NP_001191129.1 


    ENSEMBL Gene Tree for AKAP2 (if available)
    TreeFam Gene Tree for AKAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AKAP2 gene
    PALMD2  PALM2  PALM22  PALM2-AKAP22  

    AKAP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AKAP2 (see all 2707)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs606431291,2
    C--82424752(+) TAGCC-/TGACAA 2 -- int10--------
    rs1509187601,2
    C--82427550(+) GCATA-/CATCTG 2 -- int10--------
    rs345216491,2
    C--82432865(+) TTTTT-/A/TAAAAA 2 -- int11CSA 2
    rs348719671,2
    C--82450472(+) ATCTC-/AAAAAA 2 -- int10--------
    rs109801831,2
    A--82456502(+) CAAGAC/TCAGCC 2 -- int10--------
    rs109801841,2
    --82456503(+) AAGATC/TAGCCT 2 -- int10--------
    rs1472445501,2
    C--82459032(+) ACCAC-/GGG   
       GCGGG
    GGGGC
    2 -- int10--------
    rs106348361,2
    C--82465793(+) CCCTCCTT/-ATTAC 2 -- cds11Minor allele frequency- -:0.00CSA 2
    rs58998791,2
    C--82495584(+) TCTAG-/G/TAATTT 3 -- int10--------
    rs21828061,2
    C,F--82495827(-) TAGGCA/C/GAACGT 3 -- int113NS NA CSA WA EA 471

    HapMap Linkage Disequilibrium report for AKAP2 (112542769 - 112792769 bp, first 250kb of AKAP2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AKAP2 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2195369CNV Deletion18987734
    esv2658904CNV Deletion23128226
    esv2096560CNV Deletion18987734
    esv2738920CNV Deletion23290073
    esv2501710CNV Deletion19546169
    esv2619523CNV Deletion19546169
    esv2672512CNV Deletion23128226
    esv273365CNV Insertion20981092
    nsv466480CNV Loss19166990
    nsv471314CNV Loss18288195

    Human Gene Mutation Database (HGMD): AKAP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AKAP2
    DNA2.0 Custom Variant and Variant Library Synthesis for AKAP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604582    OMIM disorders: --

    7 diseases for AKAP2:    
    About MalaCards
    exfoliation syndrome    kallmann syndrome    vesicoureteral reflux    cleft lip
    esophageal squamous cell carcinoma    squamous cell carcinoma    esophagitis


    AKAP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AKAP2
    Human Genome Epidemiology (HuGE) Navigator: AKAP2 (7 documents)

    Export disorders for AKAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AKAP2 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with AKAP2)
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    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. Identification of 15 loci influencing height in a Korean population. (PubMed id 19893584)1, 4 Kim J.J....Lee J.K. (J. Hum. Genet. 2010)
    3. Replication of a genome-wide case-control study of esophageal squamous cell carcinoma. (PubMed id 18649358)1, 4 Ng D....Taylor P.R. (Int. J. Cancer 2008)
    4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative. (PubMed id 11478809)1, 2 Hu B.... Kilimann M.W. (Biochem. Biophys. Res. Commun. 2001)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. (PubMed id 22456796)1 Imamura M....Kadowaki T. (Hum. Mol. Genet. 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11217 HGNC: 372 AceView: AKAP2 Ensembl:ENSG00000241978 euGenes: HUgn11217
    ECgene: AKAP2 H-InvDB: AKAP2

    (According to HUGE)
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    HUGE: KIAA0920

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AKAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AKAP2 gene:
    Search GeneIP for patents involving AKAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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