Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AKAP2 Gene

Aliases for AKAP2 Gene

  • A-Kinase Anchoring Protein 2 2 3 5
  • A Kinase (PRKA) Anchor Protein 2 2 3
  • Protein Kinase A2 2 3
  • AKAP-2 3 4
  • PRKA2 3 4
  • Protein Kinase A Anchoring Protein 2 3
  • Protein Kinase A-Anchoring Protein 2 4
  • KIAA0920 4
  • AKAP-KL 4
  • AKAPKL 3

External Ids for AKAP2 Gene

Previous HGNC Symbols for AKAP2 Gene

  • PRKA2

Previous GeneCards Identifiers for AKAP2 Gene

  • GC09P103340
  • GC09P104135
  • GC09U900391
  • GC09P107923
  • GC09P107924
  • GC09P109623
  • GC09P111442
  • GC09P111850
  • GC09P112810
  • GC09P082413
  • GC09P112543

Summaries for AKAP2 Gene

Entrez Gene Summary for AKAP2 Gene

  • The protein encoded by this gene binds to the regulatory subunit of protein kinase A and is found associated with the actin cytoskeleton. The encoded protein mediates signals carried by cAMP and may be involved in creating polarity in certain signaling processes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for AKAP2 Gene

AKAP2 (A-Kinase Anchoring Protein 2) is a Protein Coding gene. Diseases associated with AKAP2 include kallmann syndrome. Among its related pathways are G Protein Signaling Pathways and Proton Pump Inhibitor Pathway, Pharmacodynamics. An important paralog of this gene is PALMD.

UniProtKB/Swiss-Prot for AKAP2 Gene

  • Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity).

Gene Wiki entry for AKAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP2 Gene

Genomics for AKAP2 Gene

Regulatory Elements for AKAP2 Gene

Promoters for AKAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AKAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for AKAP2 Gene

Chromosome:
9
Start:
110,048,598 bp from pter
End:
110,172,512 bp from pter
Size:
123,915 bases
Orientation:
Plus strand

Genomic View for AKAP2 Gene

Genes around AKAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP2 Gene

Proteins for AKAP2 Gene

  • Protein details for AKAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2D5-AKAP2_HUMAN
    Recommended name:
    A-kinase anchor protein 2
    Protein Accession:
    Q9Y2D5
    Secondary Accessions:
    • B1ALX9
    • B2RTU4
    • B3KQ00
    • B4DTZ2
    • B7ZW07
    • B9EJB5
    • Q9UG26

    Protein attributes for AKAP2 Gene

    Size:
    859 amino acids
    Molecular mass:
    94661 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76764.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AKAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKAP2 Gene

Proteomics data for AKAP2 Gene at MOPED

Post-translational modifications for AKAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKAP2 Gene

No data available for DME Specific Peptides for AKAP2 Gene

Domains & Families for AKAP2 Gene

Gene Families for AKAP2 Gene

Protein Domains for AKAP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AKAP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2D5

UniProtKB/Swiss-Prot:

AKAP2_HUMAN :
  • The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Domain:
  • The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
genes like me logo Genes that share domains with AKAP2: view

Function for AKAP2 Gene

Molecular function for AKAP2 Gene

GENATLAS Biochemistry:
A kinase,scaffold protein (PRKA regulatory subunit RIIA) anchor protein 2
UniProtKB/Swiss-Prot Function:
Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity).

Phenotypes for AKAP2 Gene

genes like me logo Genes that share phenotypes with AKAP2: view

Animal Model Products

miRNA for AKAP2 Gene

miRTarBase miRNAs that target AKAP2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKAP2 Gene

Localization for AKAP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP2 Gene COMPARTMENTS Subcellular localization image for AKAP2 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AKAP2 Gene

Pathways & Interactions for AKAP2 Gene

genes like me logo Genes that share pathways with AKAP2: view

Pathways by source for AKAP2 Gene

1 BioSystems pathway for AKAP2 Gene
1 PharmGKB pathway for AKAP2 Gene
1 GeneGo (Thomson Reuters) pathway for AKAP2 Gene

Interacting Proteins for AKAP2 Gene

Gene Ontology (GO) - Biological Process for AKAP2 Gene

None

No data available for SIGNOR curated interactions for AKAP2 Gene

Drugs & Compounds for AKAP2 Gene

(1) Drugs for AKAP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with AKAP2: view

Transcripts for AKAP2 Gene

Unigene Clusters for AKAP2 Gene

A kinase (PRKA) anchor protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP2 Gene

No ASD Table

Relevant External Links for AKAP2 Gene

GeneLoc Exon Structure for
AKAP2
ECgene alternative splicing isoforms for
AKAP2

Expression for AKAP2 Gene

mRNA expression in normal human tissues for AKAP2 Gene

Protein differential expression in normal tissues from HIPED for AKAP2 Gene

This gene is overexpressed in Bone marrow stromal cell (25.7) and Lung (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AKAP2 Gene



SOURCE GeneReport for Unigene cluster for AKAP2 Gene Hs.591908

genes like me logo Genes that share expression patterns with AKAP2: view

Protein tissue co-expression partners for AKAP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AKAP2 Gene

Orthologs for AKAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKAP2 35
  • 99.02 (n)
  • 98.95 (a)
-- 36
  • 96 (a)
ManyToMany
PALM2 36
  • 38 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 88 (a)
ManyToMany
PALM2 36
  • 37 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia PALM2 36
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm20459 36
  • 78 (a)
OneToMany
Akap2 16
Akap2 35
  • 83.41 (n)
  • 85.4 (a)
oppossum
(Monodelphis domestica)
Mammalia AKAP2 36
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia AKAP2 36
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Akap2 35
  • 83.63 (n)
  • 85.41 (a)
chicken
(Gallus gallus)
Aves AKAP2 36
  • 64 (a)
OneToMany
AKAP2 35
  • 67.35 (n)
  • 65.78 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.2612 35
tropical clawed frog
(Silurana tropicalis)
Amphibia akap2 35
  • 56.92 (n)
  • 53.12 (a)
Str.15035 35
zebrafish
(Danio rerio)
Actinopterygii palm2 36
  • 39 (a)
OneToMany
akap2 35
  • 57.39 (n)
  • 53.37 (a)
Species with no ortholog for AKAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKAP2 Gene

ENSEMBL:
Gene Tree for AKAP2 (if available)
TreeFam:
Gene Tree for AKAP2 (if available)

Paralogs for AKAP2 Gene

Paralogs for AKAP2 Gene

genes like me logo Genes that share paralogs with AKAP2: view

Variants for AKAP2 Gene

Sequence variations from dbSNP and Humsavar for AKAP2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_024248 -

Structural Variations from Database of Genomic Variants (DGV) for AKAP2 Gene

Variant ID Type Subtype PubMed ID
dgv494n21 CNV Gain 19592680
nsv893711 CNV Gain 21882294
nsv471314 CNV Loss 18288195
esv2619523 CNV Deletion 19546169
esv2096560 CNV Deletion 18987734
esv2672512 CNV Deletion 23128226
esv2501710 CNV Deletion 19546169
esv2195369 CNV Deletion 18987734
esv2658904 CNV Deletion 23128226
esv28884 CNV Loss 19812545
nsv466480 CNV Loss 19166990
esv2738920 CNV Deletion 23290073
esv273365 CNV Insertion 20981092
nsv466481 CNV Gain 19166990
nsv471316 CNV Gain 18288195
nsv515562 CNV Gain 19592680
nsv524745 CNV Gain 19592680
esv2752274 CNV Gain 17911159

Variation tolerance for AKAP2 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKAP2 Gene

HapMap Linkage Disequilibrium report
AKAP2
Human Gene Mutation Database (HGMD)
AKAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP2 Gene

Disorders for AKAP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AKAP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
kallmann syndrome
  • familial hypogonadism with anosmia
- elite association - COSMIC cancer census association via MalaCards
Search AKAP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AKAP2

Genetic Association Database (GAD)
AKAP2
Human Genome Epidemiology (HuGE) Navigator
AKAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKAP2
genes like me logo Genes that share disorders with AKAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AKAP2 Gene

Publications for AKAP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 3
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3

Products for AKAP2 Gene

Sources for AKAP2 Gene

Back to Top

Content