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Aliases for AKAP14 Gene

Aliases for AKAP14 Gene

  • A-Kinase Anchoring Protein 14 2 3 5
  • Protein Kinase A-Anchoring Protein 14 3 4
  • A Kinase (PRKA) Anchor Protein 14 2 3
  • A-Kinase Anchor Protein 28 KDa 3 4
  • AKAP 28 3 4
  • AKAP-14 3 4
  • AKAP28 3 4
  • PRKA14 3 4
  • A-Kinase Anchoring Protein 28 3

External Ids for AKAP14 Gene

Previous GeneCards Identifiers for AKAP14 Gene

  • GC0XP118811
  • GC0XP118913
  • GC0XP119029
  • GC0XP108526

Summaries for AKAP14 Gene

Entrez Gene Summary for AKAP14 Gene

  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way, may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKAP14 Gene

AKAP14 (A-Kinase Anchoring Protein 14) is a Protein Coding gene. GO annotations related to this gene include protein kinase A binding.

UniProtKB/Swiss-Prot for AKAP14 Gene

  • Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP14 Gene

Genomics for AKAP14 Gene

Regulatory Elements for AKAP14 Gene

Genomic Location for AKAP14 Gene

Chromosome:
X
Start:
119,895,837 bp from pter
End:
119,920,716 bp from pter
Size:
24,880 bases
Orientation:
Plus strand

Genomic View for AKAP14 Gene

Genes around AKAP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP14 Gene

Proteins for AKAP14 Gene

  • Protein details for AKAP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UN6-AKA28_HUMAN
    Recommended name:
    A-kinase anchor protein 14
    Protein Accession:
    Q86UN6
    Secondary Accessions:
    • A6NNZ0
    • Q86UN4
    • Q86UN5

    Protein attributes for AKAP14 Gene

    Size:
    197 amino acids
    Molecular mass:
    22815 Da
    Quaternary structure:
    • Binds to type II regulatory subunits (RII).

    Alternative splice isoforms for AKAP14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKAP14 Gene

Proteomics data for AKAP14 Gene at MOPED

Post-translational modifications for AKAP14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKAP14 Gene

No data available for DME Specific Peptides for AKAP14 Gene

Domains & Families for AKAP14 Gene

Gene Families for AKAP14 Gene

Protein Domains for AKAP14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AKAP14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AKAP14: view

No data available for UniProtKB/Swiss-Prot for AKAP14 Gene

Function for AKAP14 Gene

Molecular function for AKAP14 Gene

UniProtKB/Swiss-Prot Function:
Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
genes like me logo Genes that share phenotypes with AKAP14: view

Animal Model Products

miRNA for AKAP14 Gene

miRTarBase miRNAs that target AKAP14

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKAP14 Gene

Localization for AKAP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP14 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP14 Gene COMPARTMENTS Subcellular localization image for AKAP14 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for AKAP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with AKAP14: view

Pathways & Interactions for AKAP14 Gene

SuperPathways for AKAP14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AKAP14 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AKAP14 Gene

Drugs & Compounds for AKAP14 Gene

No Compound Related Data Available

Transcripts for AKAP14 Gene

Unigene Clusters for AKAP14 Gene

A kinase (PRKA) anchor protein 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP14 Gene

No ASD Table

Relevant External Links for AKAP14 Gene

GeneLoc Exon Structure for
AKAP14
ECgene alternative splicing isoforms for
AKAP14

Expression for AKAP14 Gene

mRNA expression in normal human tissues for AKAP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AKAP14 Gene

This gene is overexpressed in Testis (x34.8).

Protein differential expression in normal tissues from HIPED for AKAP14 Gene

This gene is overexpressed in Gallbladder (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AKAP14 Gene



SOURCE GeneReport for Unigene cluster for AKAP14 Gene Hs.592245

mRNA Expression by UniProt/SwissProt for AKAP14 Gene

Q86UN6-AKA28_HUMAN
Tissue specificity: Present in cilia (at protein level). Expressed in tissues containing axoneme-based organelles (cilia and/or flagella): trachea and testis. Highly expressed in airway cilia.
genes like me logo Genes that share expression patterns with AKAP14: view

Protein tissue co-expression partners for AKAP14 Gene

Primer Products

In Situ Assay Products

Orthologs for AKAP14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AKAP14 35
  • 68.57 (n)
  • 48.19 (a)
AKAP14 36
  • 48 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKAP14 35
  • 69.62 (n)
  • 49.48 (a)
mouse
(Mus musculus)
Mammalia Akap14 35
  • 65.57 (n)
  • 47.25 (a)
Akap14 16
Akap14 36
  • 16 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AKAP14 35
  • 99.49 (n)
  • 99.49 (a)
AKAP14 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akap14 35
  • 69.17 (n)
  • 49.37 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia AKAP14 36
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves AKAP14 36
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKAP14 36
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToOne
Species with no ortholog for AKAP14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AKAP14 Gene

ENSEMBL:
Gene Tree for AKAP14 (if available)
TreeFam:
Gene Tree for AKAP14 (if available)

Paralogs for AKAP14 Gene

No data available for Paralogs for AKAP14 Gene

Variants for AKAP14 Gene

Sequence variations from dbSNP and Humsavar for AKAP14 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs194282 -- 119,915,269(+) ttatg(A/T)tcccc intron-variant
rs194283 -- 119,916,160(+) caaaa(A/G)tgctt intron-variant
rs194284 -- 119,916,185(+) tcttt(C/T)ttttt intron-variant
rs194285 -- 119,917,553(+) tgagc(C/T)gagat intron-variant
rs194286 -- 119,918,245(+) gtttt(G/T)ttttT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKAP14 Gene

Variant ID Type Subtype PubMed ID
dgv2468e1 CNV Complex 17122850
dgv2469e1 CNV Complex 17122850
esv996162 CNV Insertion 20482838
nsv9969 CNV Gain 18304495
dgv203e180 CNV Gain 20482838
esv26416 CNV Gain 19812545
nsv442815 CNV CNV 18776908
nsv515676 CNV Gain 19592680
nsv433462 CNV Gain 18776910
nsv515166 CNV Complex 21397061
esv29965 CNV Gain 17803354
nsv7058 CNV Insertion 18451855
esv996782 CNV Insertion 20482838
nsv7059 CNV Insertion 18451855

Variation tolerance for AKAP14 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKAP14 Gene

HapMap Linkage Disequilibrium report
AKAP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP14 Gene

Disorders for AKAP14 Gene

Relevant External Links for AKAP14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKAP14

No disorders were found for AKAP14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKAP14 Gene

Publications for AKAP14 Gene

  1. Characterization of an A-kinase anchoring protein in human ciliary axonemes. (PMID: 12475942) Kultgen P.L. … Milgram S.L. (Mol. Biol. Cell 2002) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3

Products for AKAP14 Gene

Sources for AKAP14 Gene

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