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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AKAP14 Gene

protein-coding   GIFtS: 46
GCID: GC0XP119029

A kinase (PRKA) anchor protein 14
  Search for AKAP14
in
MalaCards
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 Human Malady Compendium 
Biological research products
for AKAP14    

Aliases
for AKAP14 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
A Kinase (PRKA) Anchor Protein 141 2     A-Kinase Anchor Protein 28 KDa2 3
AKAP281 2 3 5     AKAP 282 3
Protein Kinase A-Anchoring Protein 142 3     A-Kinase Anchor Protein 142
AKAP-142 3     A-Kinase Anchoring Protein 282
PRKA142 3     

External Ids:    HGNC: 240611   Entrez Gene: 1587982   Ensembl: ENSG000001864717   OMIM: 3004625   UniProtKB: Q86UN63   

Export aliases for AKAP14 gene to outside databases

Previous GC identifers: GC0XP118811 GC0XP118913 GC0XP108526


Summaries
for AKAP14 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AKAP14:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of
binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within
the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way,
may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different
isoforms, have been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AKA28_HUMAN, Q86UN6
Function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them




Genomic Views
for AKAP14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AKAP14 gene promoter:
         Sox5   FOXF2   FOXO3   FOXD1   FOXO3b   FOXL1   HFH-1   FOXJ2 (long isoform)   FOXO3a   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AKAP14 promoter sequence
   Search SABiosciences Chromatin IP Primers for AKAP14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKAP14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq24

AKAP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKAP14 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP119029:  view genomic region     (about GC identifiers)

Start:
 119,029,800 bp from pter      End:
 119,054,679 bp from pter
Size:
 24,880 bases      Orientation:
 plus strand

Proteins
for AKAP14 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AKA28_HUMAN, Q86UN6 (See protein sequence)
Recommended Name: A-kinase anchor protein 14  
Size: 197 amino acids; 22815 Da
Subunit: Binds to type II regulatory subunits (RII)
Subcellular location: Cytoplasm (Probable)
Secondary accessions: Q86UN4 Q86UN5
Alternative splicing: 3 isoforms:  Q86UN6-1   Q86UN6-2   Q86UN6-3   

Explore the universe of human proteins at neXtProt for AKAP14: NX_Q86UN6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86UN6

    • AKAP14 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001008534.1  NP_001008535.1  NP_848928.1  

    ENSEMBL proteins: 
     ENSP00000360485   ENSP00000360476   ENSP00000334680   ENSP00000360477   ENSP00000360479  
     ENSP00000378094  

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    Uscn Proteins for AKAP14

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--


    AKAP14 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for AKAP14 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AKAP14 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR025663 AKAP_28

    Graphical View of Domain Structure for InterPro Entry Q86UN6

    ProtoNet protein and cluster: Q86UN6


    Function
    for AKAP14 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AKA28_HUMAN, Q86UN6
    Function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051018protein kinase A binding IEA--


    AKAP14 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for AKAP14:
     Gemcitabine induced cell-death  Upregulation of NF-kappaB path 


    Pathways & Interactions
    for AKAP14 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AKAP14

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for AKAP14 (Q86UN63 ENSP000003604854) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAR2AP138613, ENSP000002655634I2D: score=2 STRING: ENSP00000265563
    MYCBPQ994173, ENSP000003807024I2D: score=1 STRING: ENSP00000380702
    PRKACAP176123, ENSP000003095914I2D: score=1 STRING: ENSP00000309591
    PRKAR2BP313233, ENSP000002657174I2D: score=1 STRING: ENSP00000265717
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007283spermatogenesis IEA--


    AKAP14 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AKAP14 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AKAP14
    Search CenterWatch for drugs/clinical trials and news about AKAP14 / AKA28 

    Transcripts
    for AKAP14 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AKAP14 gene (3 alternative transcripts): 
    NM_001008534.1  NM_001008535.1  NM_178813.5  

    Unigene Cluster for AKAP14:

    A kinase (PRKA) anchor protein 14
    Hs.592245  [show with all ESTs]
    Unigene Representative Sequence: BC066357
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371431(uc004ese.3 uc004esf.3) ENST00000371422 ENST00000334356
    ENST00000491105 ENST00000371423 ENST00000371425 ENST00000394594(uc004esd.3)


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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF514780.1 AF514781.1 AF514782.1 BC066357.1 

    5 DOTS entries:

    DT.86851991  DT.100745652  DT.95257308  DT.121289693  DT.455943 

    24/28 AceView cDNA sequences (see all 28):

    CA945061 AI419955 AI624725 AF514782 AI002127 AW137676 BX112222 AA400209 
    BU676922 AF514781 BC066357 AI867890 AA400121 NM_178813 AA883165 AF514780 
    AW340689 BI559462 CB854562 AI633252 AI652093 AW002983 BG182109 AA292847 

    GeneLoc Exon Structure


    Expression
    for AKAP14 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AKAP14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGTCATTCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AKAP14 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSpermatidGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Dorsal forebrain-like neurons (Generation of midbra...)Brain

    See AKAP14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AKAP14

    SOURCE GeneReport for Unigene cluster: Hs.592245

    UniProtKB/Swiss-Prot: AKA28_HUMAN, Q86UN6
    Tissue specificity: Present in cilia (at protein level). Expressed in tissues containing axoneme-based organelles
    (cilia and/or flagella): trachea and testis. Highly expressed in airway cilia

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP14

    Orthologs
    for AKAP14 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for AKAP14 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Akap141 , 5 A kinase (PRKA) anchor protein 141, 5 65.75(n)1
    47.25(a)1    		   X (21.57 cM)5
    4347561  NM_001033785.21  NP_001028957.11 
     371506985 
    chicken
    (Gallus gallus)    		 Aves AKAP141 A kinase (PRKA) anchor protein 14 53.33(n)
    39.38(a)    		   772147  XM_001234243.2  XP_001234244.1 
    lizard
    (Anolis carolinensis)    		 Reptilia AKAP146
    		 --
    		 37(a)
    		 1 ↔ 1
    		 GL343950.1(73263-77044)
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 16(a)
    		 1 ↔ 1
    		 Group7.11(211087-211884)


    ENSEMBL Gene Tree for AKAP14 (if available)
    TreeFam Gene Tree for AKAP14 (if available) 

    Paralogs
    for AKAP14 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for AKAP14 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/360 NCBI SNPs in AKAP14 are shown (see all 360)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs48254121,2
    		C,H--119027990(+) AAAAAA/GAGAGA 3 -- us2k1 trp31Minor allele frequency- G:0.00NA 2
    rs24282271,2
    		C,F,A,H,--119028008(+) AGAGAA/GAAAGA 3 -- us2k1 trp316Minor allele frequency- G:0.12NS EA WA NA CSA 1750
    rs1894227871,2
    		--119028216(+) TTTCAA/TCTTTG 3 -- us2k10--------
    rs1807061391,2
    		--119028438(+) ATTTAC/GTGAGC 3 -- us2k10--------
    rs24282291,2
    		C,--119028451(+) gagacA/Ggatac 3 -- us2k10--------
    rs1837899821,2
    		--119028483(+) TGCTCG/TTTTTC 3 -- us2k10--------
    rs778902461,2
    		C--119028518(+) TGTGAC/GCATAC 3 -- us2k10--------
    rs24961911,2
    		C,--119028554(+) atttcC/Tccttt 3 -- us2k1 tfbs3 trp30--------
    rs24282301,2
    		C,--119028573(+) tatttT/Attatt 3 -- us2k1 tfbs31Minor allele frequency- A:0.00CSA 1
    rs24282311,2
    		C,--119028624(+) tgcccA/Gggttg 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for AKAP14 (119029800 - 119054679 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 15 variations for AKAP14
         15 CNVs: 36996 23330 52918 38928 68023 31559 83711 52917 96928 68021 37639 36995 4167 96929 83712
    Locus Specific Mutation Databases (LSDB): AKAP14

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    Disorders / Diseases
    for AKAP14 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AKAP14 for disorders           About MalaCards

    AKAP14 for disorders           About GeneDecksing

    OMIM gene information: 300462    OMIM disorders: --


    Export disorders for AKAP14 gene to outside databases

    Publications
    for AKAP14 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AKAP14 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with AKAP14)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of an A-kinase anchoring protein in human ciliary axonemes. (PubMed id 12475942)1, 2, 3 Kultgen P.L.... Milgram S.L. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    4. Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)

    External Searches for AKAP14 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing AKAP14 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 158798 HGNC: 24061 AceView: AKAP14 Ensembl:ENSG00000186471 euGenes: HUgn158798
    ECgene: AKAP14 H-InvDB: AKAP14

    Other Databases showing AKAP14 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AKAP14 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AKAP14 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AKAP14 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AKAP14 gene:
    Search GeneIP for patents involving AKAP14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for AKAP14 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
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     Browse OriGene Antibodies   OriGene shRNA RFP for AKAP14  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKAP14   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKAP14  
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AKAP14
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     GenScript Custom Purified and Recombinant Proteins Services for AKAP14 GenScript cDNA clones with any tag delivered in your preferred vector for AKAP14
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     Regulatory tfbs in AKAP14 promoter
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     Browse Sino Biological Proteins and Antibodies
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     Search for Antibodies for AKAP14 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for AKAP14
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     AKAP14 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for AKAP14
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP14
     Browse SwitchGear 3'UTR luciferase reporter plasmids for AKAP14
     SwitchGear Promoter luciferase reporter plasmids for AKAP14
     ThermoFisher Antibodies for AKAP14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKAP14
           
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