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Aliases for AKAP13 Gene

Aliases for AKAP13 Gene

  • A-Kinase Anchoring Protein 13 2 3 5
  • Lymphoid Blast Crisis Oncogene 2 3 4
  • Breast Cancer Nuclear Receptor-Binding Auxiliary Protein 3 4
  • Non-Oncogenic Rho GTPase-Specific GTP Exchange Factor 3 4
  • Guanine Nucleotide Exchange Factor Lbc 3 4
  • Protein Kinase A-Anchoring Protein 13 3 4
  • Human Thyroid-Anchoring Protein 31 3 4
  • A Kinase (PRKA) Anchor Protein 13 2 3
  • LBC Oncogene 3 4
  • AKAP-Lbc 3 4
  • AKAP-13 3 4
  • PRKA13 3 4
  • Ht31 3 4
  • LBC 3 4
  • BRX 3 4
  • P47 3 4
  • A-Kinase Anchor Protein 13 3
  • A-Kinase Anchoring Protein 3
  • PROTO-LBC 3
  • ARHGEF13 3
  • PROTO-LB 3
  • C-Lbc 3
  • HA-3 3

External Ids for AKAP13 Gene

Previous HGNC Symbols for AKAP13 Gene

  • LBC

Previous GeneCards Identifiers for AKAP13 Gene

  • GC15M082290
  • GC15P079144
  • GC15P083511
  • GC15P083653
  • GC15P083724
  • GC15P083578
  • GC15P085925
  • GC15P061986
  • GC15P085777

Summaries for AKAP13 Gene

Entrez Gene Summary for AKAP13 Gene

  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]

GeneCards Summary for AKAP13 Gene

AKAP13 (A-Kinase Anchoring Protein 13) is a Protein Coding gene. Diseases associated with AKAP13 include Tick-Borne Relapsing Fever and Relapsing Fever. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include signal transducer activity and protein complex scaffold. An important paralog of this gene is ARHGEF28.

UniProtKB/Swiss-Prot for AKAP13 Gene

  • Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity).

Gene Wiki entry for AKAP13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP13 Gene

Genomics for AKAP13 Gene

Regulatory Elements for AKAP13 Gene

Enhancers for AKAP13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F085442 1.5 FANTOM5 Ensembl ENCODE 9.7 +63.6 63552 3.0 TBP PKNOX1 TBL1XR1 INSM2 ARID4B BMI1 FEZF1 RAD21 RFX5 SLC30A9 FABP5P9 ADAMTS7P4 AKAP13 GC15M085415 GC15P085515
GH15F085701 1.7 FANTOM5 Ensembl ENCODE 7.8 +324.9 324867 8.7 HDGF PKNOX1 ATF1 MLX WRNIP1 ARID4B ZNF48 YY1 ZNF207 JUNB LOC105370950 RNU6-1280P RNU6-231P ENSG00000259407 AKAP13 ENSG00000259762 KLHL25 ENSG00000259453 ENSG00000259544
GH15F085666 1.4 FANTOM5 Ensembl ENCODE 8.2 +287.7 287736 3.7 MXI1 WRNIP1 JUN SIN3A BMI1 RAD21 ZBTB40 FOS CREM NFE2L2 LOC105370950 ENSG00000259407 AKAP13 ENSG00000259762 KLHL25 ENSG00000259367 GC15M085652 RNU6-1280P
GH15F085400 1.5 FANTOM5 Ensembl ENCODE 6.4 +24.1 24130 9.4 HDGF BMI1 FEZF1 RARA GLIS2 ZNF366 CBX5 SCRT2 SMARCC2 ETV6 LOC105370950 FABP5P9 ADAMTS7P4 GOLGA6L5P AKAP13 ENSG00000259762 LOC103171574 PDE8A RNU7-79P
GH15F085410 1.7 FANTOM5 Ensembl ENCODE 5.2 +32.6 32603 4.5 PKNOX1 MLX SIN3A ARID4B DMAP1 SLC30A9 CBX5 FOS DEK JUNB RNU7-79P FABP5P9 WDR73 ADAMTS7P4 LOC105370950 ENSG00000259762 AKAP13 PDE8A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AKAP13 on UCSC Golden Path with GeneCards custom track

Promoters for AKAP13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000412800 429 3201 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF48 ZNF2 YY1 GLIS2 ZNF143

Genomic Location for AKAP13 Gene

Chromosome:
15
Start:
85,380,571 bp from pter
End:
85,749,358 bp from pter
Size:
368,788 bases
Orientation:
Plus strand

Genomic View for AKAP13 Gene

Genes around AKAP13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAP13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAP13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP13 Gene

Proteins for AKAP13 Gene

  • Protein details for AKAP13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12802-AKP13_HUMAN
    Recommended name:
    A-kinase anchor protein 13
    Protein Accession:
    Q12802
    Secondary Accessions:
    • Q14572
    • Q59FP6
    • Q86W90
    • Q8WXQ6
    • Q96JP6
    • Q96P79
    • Q9Y5T0
    • Q9Y5T6

    Protein attributes for AKAP13 Gene

    Size:
    2813 amino acids
    Molecular mass:
    307550 Da
    Quaternary structure:
    • Interacts with the cAMP-dependent protein kinase (PKA) holoenzyme and with the regulatory subunit PRKAR2A (PubMed:11546812, PubMed:1618839, PubMed:15229649, PubMed:21102438, PubMed:11285229). Interacts with RHOA (PubMed:11546812, PubMed:17537920, PubMed:25186459, PubMed:24993829). Interacts also with RHOB and RHOC (PubMed:11546812). Identified in a ternary complex with RHOA and PRKAR2A (PubMed:11546812). Identified in a complex with NR3C1 and RHOA (PubMed:16469733). Interacts with BRAF and KSR1 (PubMed:21102438). Identified in a complex with BRAF and KSR1 (PubMed:21102438). Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381). Interacts (phosphorylated form) with YWHAB and YWHAZ (PubMed:15229649, PubMed:21224381). Interaction with YWHAB inhibits activation of RHOA, interferes with PKN1 binding and activation of MAP kinases (PubMed:15229649, PubMed:21224381). Interacts with GNA12 (PubMed:11546812). Interacts with IKBKB (PubMed:23090968). Interacts with ESR1, THRA, PPARA and NME2 (PubMed:9627117, PubMed:15249197). Interacts (via the C-terminal domain after the PH domain) with MEF2C and RXRB. Interacts (via the C-terminal domain after the PH domain) with PRKD1 (By similarity).
    • Interacts with the cAMP-dependent protein kinase (PKA) holoenzyme and with the regulatory subunit PRKAR2A (PubMed:11546812, PubMed:1618839, PubMed:15229649, PubMed:21102438, PubMed:11285229). Interacts with RHOA (PubMed:11546812, PubMed:17537920, PubMed:25186459, PubMed:24993829). Interacts also with RHOB and RHOC (PubMed:11546812). Identified in a ternary complex with RHOA and PRKAR2A (PubMed:11546812). Identified in a complex with NR3C1 and RHOA (PubMed:16469733). Interacts with BRAF and KSR1 (PubMed:21102438). Identified in a complex with BRAF and KSR1 (PubMed:21102438). Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381). Interacts (phosphorylated form) with YWHAB and YWHAZ (PubMed:15229649, PubMed:21224381). Interaction with YWHAB inhibits activation of RHOA, interferes with PKN1 binding and activation of MAP kinases (PubMed:15229649, PubMed:21224381). Interacts with GNA12 (PubMed:11546812). Interacts with IKBKB (PubMed:23090968). Interacts with ESR1, THRA, PPARA and NME2 (PubMed:9627117, PubMed:15249197). Interacts (via the C-terminal domain after the PH domain) with MEF2C and RXRB. Interacts (via the C-terminal domain after the PH domain) with PRKD1 (By similarity).
    SequenceCaution:
    • Sequence=AAC50065.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC50065.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAD21311.1; Type=Frameshift; Positions=2614, 2647; Evidence={ECO:0000305}; Sequence=AAD40799.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD40799.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAL40923.1; Type=Frameshift; Positions=2614, 2647; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AKAP13 Gene

    Alternative splice isoforms for AKAP13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKAP13 Gene

Post-translational modifications for AKAP13 Gene

  • Ubiquitination at Lys 186
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for AKAP13

No data available for DME Specific Peptides for AKAP13 Gene

Domains & Families for AKAP13 Gene

Suggested Antigen Peptide Sequences for AKAP13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12802

UniProtKB/Swiss-Prot:

AKP13_HUMAN :
  • The DH domain is sufficient for interaction with RHOA, and for guanine nucleotide exchange (GEF) activity with RHOA (PubMed:24993829). Forms that lack C-terminal regulatory domains have transforming activity and function as oncogenes (PubMed:9891067).
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • The DH domain is sufficient for interaction with RHOA, and for guanine nucleotide exchange (GEF) activity with RHOA (PubMed:24993829). Forms that lack C-terminal regulatory domains have transforming activity and function as oncogenes (PubMed:9891067).
  • The PH domain does not play a role in lipid-binding. Instead, it inhibits the guanine nucleotide exchange (GEF) activity of the isolated DH domain (in vitro).
  • The C-terminal domain after the PH domain is involved in protein-protein interactions that are required for normal, compensatory cardiac hypertrophy in response to pressure overload.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with AKAP13: view

Function for AKAP13 Gene

Molecular function for AKAP13 Gene

GENATLAS Biochemistry:
A kinase (PRKA regulatory subunit RII) anchor protein 13
UniProtKB/Swiss-Prot Function:
Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for AKAP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004691 cAMP-dependent protein kinase activity IEA --
GO:0004871 signal transducer activity TAS 8290273
GO:0005078 MAP-kinase scaffold activity IDA 21224381
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA,TAS --
genes like me logo Genes that share ontologies with AKAP13: view
genes like me logo Genes that share phenotypes with AKAP13: view

Animal Models for AKAP13 Gene

MGI Knock Outs for AKAP13:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AKAP13 Gene

Localization for AKAP13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP13 Gene

Cytoplasm, cytosol. Cytoplasm. Cytoplasm, cell cortex. Nucleus. Membrane; Peripheral membrane protein. Note=Colocalizes with the actin cytoskeleton at the cell cortex. {ECO:0000269 PubMed:11546812}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKAP13 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for AKAP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005884 actin filament IEA --
genes like me logo Genes that share ontologies with AKAP13: view

Pathways & Interactions for AKAP13 Gene

genes like me logo Genes that share pathways with AKAP13: view

SIGNOR curated interactions for AKAP13 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for AKAP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007186 G-protein coupled receptor signaling pathway IDA 11546812
GO:0007507 heart development IEA,ISS --
GO:0010611 regulation of cardiac muscle hypertrophy IEA --
GO:0035023 regulation of Rho protein signal transduction IEA --
genes like me logo Genes that share ontologies with AKAP13: view

Drugs & Compounds for AKAP13 Gene

(18) Drugs for AKAP13 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
calcium Nutra 0

(10) Additional Compounds for AKAP13 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with AKAP13: view

Transcripts for AKAP13 Gene

Unigene Clusters for AKAP13 Gene

A kinase (PRKA) anchor protein 13:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - -
SP2: -
SP3:
SP4:
SP5:
SP6:

ExUns: 22a · 22b ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for AKAP13 Gene

GeneLoc Exon Structure for
AKAP13
ECgene alternative splicing isoforms for
AKAP13

Expression for AKAP13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AKAP13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AKAP13 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.6) and Adrenal (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AKAP13 Gene



Protein tissue co-expression partners for AKAP13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AKAP13 Gene:

AKAP13

SOURCE GeneReport for Unigene cluster for AKAP13 Gene:

Hs.459211

mRNA Expression by UniProt/SwissProt for AKAP13 Gene:

Q12802-AKP13_HUMAN
Tissue specificity: Detected in mammary gland (PubMed:9627117). Detected in heart (at protein level) (PubMed:11546812). Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle.
genes like me logo Genes that share expression patterns with AKAP13: view

Primer Products

No data available for mRNA differential expression in normal tissues for AKAP13 Gene

Orthologs for AKAP13 Gene

This gene was present in the common ancestor of animals.

Orthologs for AKAP13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKAP13 34 35
  • 99.41 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 89 (a)
OneToMany
-- 35
  • 69 (a)
OneToMany
dog
(Canis familiaris)
Mammalia AKAP13 34 35
  • 83.89 (n)
mouse
(Mus musculus)
Mammalia Akap13 34 16 35
  • 79.71 (n)
rat
(Rattus norvegicus)
Mammalia Akap13 34
  • 79.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AKAP13 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AKAP13 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves AKAP13 34 35
  • 70.26 (n)
lizard
(Anolis carolinensis)
Reptilia AKAP13 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia akap13 34
  • 63.66 (n)
zebrafish
(Danio rerio)
Actinopterygii AKAP13 (1 of 2) 35
  • 59 (a)
OneToMany
AKAP13 (2 of 2) 35
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10188 36 35
  • 30 (a)
Species where no ortholog for AKAP13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKAP13 Gene

ENSEMBL:
Gene Tree for AKAP13 (if available)
TreeFam:
Gene Tree for AKAP13 (if available)

Paralogs for AKAP13 Gene

Paralogs for AKAP13 Gene