V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

AKAP13 Gene

protein-coding GIFtS: 66

GC15P083724

A kinase (PRKA) anchor protein 13
(Previous name: lymphoid blast crisis oncogene )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: LBC)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AKAP-Lbc ^¹, ², ³
ARHGEF13 ^¹, ²
BRX ^¹, ², ³, ⁵
FLJ11952 ^²
FLJ43341 ^²
HA-3 ^¹, ²
HT31 ^³, ⁵
Ht31 ^¹, ²
LBC ^², ³, ⁵
P47 ^³
PROTO-LB ^¹, ²
PROTO-LBC ^²
c-lbc ^¹, ²

Descriptions
A kinase (PRKA) anchor protein 13 ^²
A kinase anchor protein 13 ^¹
A-kinase anchor protein 13 ^²
A-kinase anchoring protein ^²
AKAP 13 ^³
Breast cancer nuclear receptor-binding auxiliary protein ^², ³
Guanine nucleotide exchange factor Lbc ^², ³
Human thyroid-anchoring protein 31 ^³
LBC oncogene ^³
Lymphoid blast crisis oncogene ^¹, ², ³
Non-oncogenic Rho GTPase-specific GTP exchange factor ^³
Protein kinase A-anchoring protein 13 ^³

External Ids
HGNC: 371¹
Entrez Gene: 11214²
UniProtKB: Q12802³
Ensembl: ENSG00000170776⁷

Search outside databases for aliases for AKAP13 gene

Previous GC identifers: GC15M082290 GC15P079144 GC15P083511 GC15P083653 GC15P083578

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AKAP13:

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the

common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the

holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family.

Alternative splicing of this gene results in at least 3 transcript variants encoding different

isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The

DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of

small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form

capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms

function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function

as protein kinase A-anchoring proteins. [provided by RefSeq]

UniProtKB/Swiss-Prot: AKP13_HUMAN, Q12802

Function: Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively

couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an

element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38

MAPK-dependent pathway. Isoform 6 stimulates exchange activity on Rho proteins in vitro, but not

on CDC42, Ras or Rac and may bind calcium ions

Gene Wiki entry for AKAP13

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AKAP13 gene

Entrez Gene cytogenetic band: 15q24-q25 Ensembl cytogenetic band: 15q25.3 HGNC cytogenetic band: 15q24-q25

AKAP13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P083724: (about GC identifiers)

Start:	83,724,875 bp from pter
End:	84,093,590 bp from pter
Size:	368,716 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000015.8 NT_010274.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AKP13_HUMAN, Q12802 (See protein sequence)

Recommended Name: A-kinase anchor protein 13

Size: 2813 amino acids; 307550 Da

Subunit: Binds cAMP-dependent protein kinase (PKA) and to the RII-alpha regulatory subunit of PKA.

Interacts with ESR1, ESR2, THRA, PPARA, RHOA and NME2

Subcellular location: Isoform 3: Cytoplasm. Nucleus

Subcellular location: Isoform 2: Cytoplasm

Subcellular location: Isoform 6: Cytoplasm

Subcellular location: Isoform 7: Membrane

Sequence caution: Sequence=AAD21311.1; Type=Frameshift; Positions=2614, 2647; Sequence=AAL40923.1;

Type=Frameshift; Positions=2614, 2647;

PDB structures from and Proteopedia :

2DRN (3D)

Secondary accessions: Q14572 Q59FP6 Q86W90 Q8WXQ6 Q96JP6 Q96P79 Q9Y5T0 Q9Y5T6

Alternative splicing: 7 isoforms: Q12802-1 Q12802-2 Q12802-3 Q12802-4 Q12802-5 Q12802-6 Q12802-7

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_006729.4 NP_009131.2 NP_658913.1

ENSEMBL proteins:

ENSP00000378024 ENSP00000378026 ENSP00000378018 ENSP00000354718

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AKAP13)
	Human Recombinant Proteins from Abnova (AKAP13)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	IEA	--
GO:0005624	membrane fraction	TAS	9891067
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for AKAP13:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of AKAP13
	Sigma-Aldrich Antibodies for AKAP13
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (AKAP13), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AKAP13)
	Novus Biologicals Antibodies for AKAP13

Assays for AKAP13:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q12802

ProtoNet protein and cluster: Q12802

2 Blocks protein families:

IPB000219 DH domain

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: AKP13_HUMAN, Q12802

Domain: Both the DH and PH domains are required for transforming activity

Similarity: Contains 1 DH (DBL-homology) domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 phorbol-ester/DAG-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AKAP13)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AKAP13)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_144767

Applied Biosystems Silencer® siRNAs for AKAP13

Sigma-Aldrich siRNA and siRNA Panels for AKAP13

Sigma-Aldrich shRNA for AKAP13

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AKAP13
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_006738
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_006738
untagged cDNA clones in CMV expression vector (see all 4): NM_006738

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006738

UniProtKB/Swiss-Prot: AKP13_HUMAN, Q12802

Function: Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively

couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an

element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38

MAPK-dependent pathway. Isoform 6 stimulates exchange activity on Rho proteins in vitro, but not

on CDC42, Ras or Rac and may bind calcium ions

Genatlas biochemistry entry for AKAP13:

A kinase (PRKA regulatory subunit RII) anchor protein 13

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004691	cAMP-dependent protein kinase activity	NAS	1618839
GO:0004871	signal transducer activity	TAS	8290273
GO:0005085	guanyl-nucleotide exchange factor activity	IEA	--
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005515	protein binding	IPI	16301118 17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for AKAP13 (Your Favorite Gene powered by Ingenuity)

Cardiac &beta
cAMP-mediated Signaling

GeneDecks AKAP13 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for AKAP13

5/100 Interacting proteins for AKAP13 (Q12802¹ ENSP00000354718³) via UniProtKB, MINT, and/or STRING (see all 100 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAB	P31946¹, ENSP00000361930³	EBI-1373806, EBI-359815 STRING (score=.753)
BAK1	Q16611¹	EBI-1373806, EBI-519866
TGM2	P21980¹	EBI-1373806, EBI-727668
PRKAR2A	ENSP00000265563³	STRING (score=.976)
CDC42P2	ENSP00000314458³	STRING (score=.975)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007242	intracellular signaling cascade	IEA	--
GO:0008150	biological_process	ND	--
GO:0035023	regulation of Rho protein signal transduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AKAP13
10/16 Novoseek chemical compound relationships for AKAP13 gene (see all 16 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cyclic amp	51.98	5	16540556 (1), 17081989 (1), 16460837 (1), 10074940 (1)
forskolin	38.12	3	10887192 (1), 12777250 (1)
threonine	26.07	3	17200117 (1), 11823486 (1), 16700649 (1)
calcium	20.65	11	9620705 (2), 11258666 (1), 15652351 (1), 9545239 (1) (see all 6)
ryanodine	20.29	3	12709444 (1), 11258666 (1), 15652351 (1)
gdp	15.83	4	8910315 (3), 11696353 (1)
potassium	10.33	5	15710486 (1), 11287423 (1), 16647783 (1), 16002409 (1) (see all 5)
gtp	8.99	1	11696353 (1)
tyrosine	3.84	3	15342355 (1), 17200117 (1), 12509440 (1)
atp	0.00	1	10600928 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AKAP13)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AKAP13)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_144767

Sigma-Aldrich siRNA and siRNA Panels for AKAP13

Sigma-Aldrich shRNA for AKAP13

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006738 NM_007200 NM_144767

REFSEQ mRNAs for AKAP13 gene (3 alternative transcripts):

NM_006738.4 NM_007200.3 NM_144767.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006738 NM_007200 NM_144767

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_006738
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_006738
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_006738

Additional cDNA sequence: AK022014.1

24/35 DOTS entries (see all 35 ):

DT.95104508 DT.100795176 DT.95291719 DT.40214988 DT.95298158 DT.100795183 DT.75170979 DT.307348

DT.86857503 DT.100686517 DT.100713955 DT.121018027 DT.121018104 DT.99941659 DT.100685917 DT.97770739

DT.92453875 DT.92453880 DT.95275310 DT.100032362 DT.100646339 DT.121018025 DT.121018132 DT.40263503

24/60 AceView cDNA sequences (see all 60 ):

BQ225311 AW440054 AI679155 BM673486 CA424347 CA416389 BM129627 R82598

AA835490 AI864082 BM969106 AI885889 T40618 BM707378 T50096 N41455

BM129808 AA704565 BQ021860 AA332594 C01311 AA029344 N29395 AW794724

highest scoring ESTs for AKAP13:

AA029344 AA534713 AI674926 AA029343 AA040150 AA113166 AA312928 AA332594 AA347605 AA347723

Unigene Clusters for AKAP13:

A kinase (PRKA) anchor protein 13

Hs.459211 [show with all ESTs], Hs.710656 [show with all ESTs]

Unigene Representative Sequences: NM_006738, AK022014

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for AKAP13 (see all 6 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20	^	21	^
SP1:											-																				-		-
SP2:																																	-
SP3:
SP4:
SP5:

ExUns:	22a	·	22b	^	23
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for AKAP13

4 Ensembl transcripts including schematic representations:

ENST00000394516 ENST00000394518 ENST00000394510 ENST00000361243

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AKAP13 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AKAP13

¹ / ² / ³

26 probe-sets matching AKAP13 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
53972_at²^{, 3}	U95-B	1	1.00	1.00	0.19	0.32	AA044176	0.60	1.00	0.82	1
45330_at²^{, 3}	U95-B	1	1.00	1.00	0.92	1.55	AA534713	1.00	1.00	1.00	1
62466_at²^{, 3}	U95-C	1	1.00	1.00	0.29	0.57	AI797853	0.80	1.00	0.91	1
735_s_at²^{, 3}	U95-A	1	1.00	1.00	0.12	0.35	HG2167-HT2237	0.20	1.00	0.72	1
45861_at²^{, 3}	U95-B	1	1.00	1.00	0.75	0.98	AI674926	1.00	1.00	1.00	1
44769_at²^{, 3}	U95-B	1	1.00	1.00	0.94	1.49	AA029344	1.00	1.00	1.00	1
89813_at²^{, 3}	U95-E	1	0.94	1.00	0.64	0.85	AW014130	0.80	1.00	0.91	1
554_at²^{, 3}	U95-A	2	0.50	0.89	0.43	0.59	U03634	0.40	1.00	0.76	1
222023_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK022014	0.60	1.00	0.82	1
222024_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK022014	0.60	1.00	0.82	1
224884_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW575773	0.80	1.00	0.91	1
221718_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M90360	0.60	1.00	0.82	1
227039_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI674926	1.00	1.00	1.00	1
209534_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF222823	0.40	1.00	0.76	1
208325_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006738	0.60	1.00	0.82	1
209535_s_at*²^{, 3}	U133-A	1	1.00	1.00	--	--	AF127481	0.40	1.00	0.76	1
232188_at*²^{, 3}	U133-B	NULL	0.00	0.00	--	--	AL133427	0.40	1.00	0.76	1
222023_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222024_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224884_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221718_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227039_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209534_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208325_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209535_s_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
232188_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks AKAP13 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTATAGATA

SOURCE GeneReport for Unigene clusters: Hs.459211 Hs.710656
Expression variation in blood from EXPOLDB for AKAP13
UniProtKB/Swiss-Prot: AKP13_HUMAN, Q12802
Tissue specificity: Isoform 3 and isoform 6 are found in hematopoietic cells, skeletal muscle,
lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also
found in testis and breast cancer cell lines. Isoform 6 is not found in brain, placenta, liver,
pancreas or kidney. Isoform 7 is expressed in myeloid and lymphoid lineages, a variety of
epithelial tissues and skeletal muscle. Isoform 2 is predominantly found in the heart and at lower
levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AKAP13 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AKAP13¹	--	A kinase (PRKA) anchor protein 13	83.93(n) 78.96(a)	479032 XM_536182.2 XP_536182.2
chimpanzee (Pan troglodytes)	AKAP13¹	--	A kinase (PRKA) anchor protein 13	99.38(n) 99.14(a)	743772 XM_001163760.1 XP_001163760.1
mouse (Mus musculus)	Akap13^{1, 5}	7⁵	A kinase (PRKA) anchor protein 13^{1, 5}	80.1(n)¹ 74.9(a)¹	75547¹ XM_133543.7¹ XP_133543.7¹ AK006382⁵ AK018023⁵ (see all 23)
chicken (Gallus gallus)	AKAP13¹	--	A kinase (PRKA) anchor protein 13	70.06(n) 68.49(a)	415502 XM_413874.2 XP_413874.2
zebrafish (Danio rerio)	wu:fi40d09¹	--	wu:fi40d09	49.71(n) 41.39(a)	556620 XM_679462.3 XP_684554.3

About this table Species with no ortholog for AKAP13

ENSEMBL Gene Tree for AKAP13

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AKAP13 gene

ENSG00000214944² ARHGEF2² ARHGEF18² ENSG00000038102²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2520 NCBI SNPs in AKAP13 are shown (see all 2520 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 817)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1053992^1,2	A,C,F,H,O	84089522(+)	`CACCCG/CTGTTT`	3	--	ut3¹ ese³		8	MN NA EU EA WA	742
	rs1808339^1,2	A,C,F,H,O	84089271(-)	`AGGCAG/TTCGGA`	3	--	ut3¹		11	EA NA EU WA	908
	rs2061822^1,2	A,C,F,H,O	83923783(+)	`CTGTTC/TGGAAG`	2	W/R	mis¹		13	EU EA WA NA	1118
	rs870689^1,2	A,C,F,H,O	84092261(-)	`TCCCAC/TCCTCT`	3	--	ut3¹ ese³		13	MN EU EA WA NA	2066
	rs2061821^1,2	A,C,F,H,O	83923658(+)	`GGTCAC/TGGAGC`	2	M/T	mis¹		8	EU EA WA	838
	rs2061824^1,2	A,C,F,H,O	83924023(+)	`GAAGTT/CGTGAG`	2	C/R	mis¹		9	EU EA WA NA	902
	rs7173923^1,2	A,C,F,H	84093475(+)	`CGAATT/ATTGCC`	3	--	ut3¹		12	MN EU EA WA NA	1164
	rs2614666^1,2	A,C,F,H	84093026(-)	`CGGTGG/ACAGGG`	3	--	ut3¹ ese³		7	NA EU EA WA	562
	rs745191^1,2	A,C,F,H	83924174(+)	`TCTTGG/TGCTGG`	2	G/V	mis¹ ese³		9	EU EA WA NA	904
	rs338515^1,2	C,F,H,O	84019771(-)	`GTACGG/CAAAAG`	3	--	int¹ ng5¹		11	EU EA WA NA	980

About this table

HapMap Linkage Disequilibrium images for AKAP13 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604686

7 Novoseek disease relationships for AKAP13 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cystic fibrosis	7.19	1	10600928 (1)
cancer	2.34	5	16234258 (2), 15059896 (1)
tumors	1.85	1	17577780 (1)
colon cancer	0.00	1	15059896 (1)
breast cancer	0.00	3	16412732 (2), 16234258 (1)
prostate cancer	0.00	3	16301118 (2)
astrocytoma	0.00	1	11278452 (1)

About this table

Human Gene Mutation Database: AKAP13
Genetic Association Database: AKAP13
Human Genome Epidemiology Navigator: AKAP13 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/197 PubMed articles for AKAP13 gene (see all 197 ):

Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action. (PubMed id 9627117)^{1, 2, 3, 4} Rubino D.... Segars J. (1998)
Lbc proto-oncogene product binds to and could be negatively regulated by metastasis suppressor nm23-H2. (PubMed id 15249197)^{1, 3, 4} Iwashita S.... Miyamoto M. (2004)
Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. (PubMed id 11696353)^{1, 3, 4} Klussmann E.... Rosenthal W. (2001)
Association of genetic variants in the Rho guanine nucleotide exchange factor AKAP13 with familial breast cancer. (PubMed id 16234258)^{1, 3, 6} Wirtenberger M....Burwinkel B. (2006)
Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products. (PubMed id 8290273)^{1, 3, 4} Toksoz D. and Williams D.A. (1994)
AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation. (PubMed id 11546812)^{1, 3, 4} Diviani D.... Scott J.D. (2001)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway. (PubMed id 11579095)^{3, 4} Driggers P.H.... Rubino D.M. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 11214	HGNC: 371	AceView: AKAP13.1	Ensembl:ENSG00000170776	euGenes: HUgn11214
ECgene: AKAP13	H-InvDB: AKAP13

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for AKAP13	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for AKAP13
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AKAP13:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AKAP13-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AKAP13		Antibodies for AKAP13
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AKAP13		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (AKAP13)
	Antibodies (AKAP13)
	Chimera RNAi (AKAP13)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (AKAP13)
	Antibodies (AKAP13)

Search OriGene for AKAP13

Search Tocris compounds for AKAP13

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for AKAP13

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
AKAP13 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

AKAP13 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for AKAP13

Summaries
for AKAP13

Genomic Location
for AKAP13

Proteins
for AKAP13

Protein Domains/
Families
for AKAP13

Gene Function
for AKAP13

Pathways & Interactions
for AKAP13

Drugs & Compounds
for AKAP13

Transcripts
for AKAP13

Expression
for AKAP13

Orthologs
for AKAP13

Paralogs
for AKAP13

SNPs/Variants
for AKAP13

Disorders & Mutations
for AKAP13

Medical News
for AKAP13

Publications
for AKAP13

Search for AKAP13

Genome Databases showing AKAP13

Other Databases showing AKAP13

Specialized Databases showing AKAP13

Licensable Technologies
for AKAP13

Services
for AKAP13

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AKAP13 (Gene Symbol)
AKAP-Lbc
ARHGEF13
BRX
FLJ11952
FLJ43341
HA-3
HT31
Ht31
LBC
P47
PROTO-LB
PROTO-LBC
c-lbc
A kinase (PRKA) anchor protein 13
A kinase anchor protein 13
A-kinase anchor protein 13
A-kinase anchoring protein
AKAP 13
Breast cancer nuclear receptor-binding auxiliary protein
Guanine nucleotide exchange factor Lbc
Human thyroid-anchoring protein 31
LBC oncogene
Lymphoid blast crisis oncogene
Non-oncogenic Rho GTPase-specific GTP exchange factor
Protein kinase A-anchoring protein 13

AKAP13 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor AKAP13

Summariesfor AKAP13

Genomic Locationfor AKAP13

Proteinsfor AKAP13

Protein Domains/Familiesfor AKAP13

Gene Functionfor AKAP13

Pathways & Interactionsfor AKAP13

Drugs & Compoundsfor AKAP13

Transcriptsfor AKAP13

Expression for AKAP13

Orthologsfor AKAP13

Paralogsfor AKAP13

SNPs/Variantsfor AKAP13

Disorders & Mutationsfor AKAP13

Medical Newsfor AKAP13

Publicationsfor AKAP13

Search for AKAP13

Genome Databases showing AKAP13

Other Databases showing AKAP13

Specialized Databases showing AKAP13

Licensable Technologiesfor AKAP13

Servicesfor AKAP13

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AKAP13

Summaries
for AKAP13

Genomic Location
for AKAP13

Proteins
for AKAP13

Protein Domains/
Families
for AKAP13

Gene Function
for AKAP13

Pathways & Interactions
for AKAP13

Drugs & Compounds
for AKAP13

Transcripts
for AKAP13

Expression
for AKAP13

Orthologs
for AKAP13

Paralogs
for AKAP13

SNPs/Variants
for AKAP13

Disorders & Mutations
for AKAP13

Medical News
for AKAP13

Publications
for AKAP13

Licensable Technologies
for AKAP13

Services
for AKAP13