AKAP13 Gene
protein-coding GIFtS : 66
GCID: GC15 P085925
A kinase (PRKA) anchor protein 13 (Previous name: lymphoid blast crisis oncogene ) (Previous symbol: LBC )
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Aliasesfor AKAP13 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases A Kinase (PRKA) Anchor Protein 13 1 2 Human Thyroid-Anchoring Protein 312 3 BRX1 2 3 5 Non-Oncogenic Rho GTPase-Specific GTP Exchange Factor2 3 LBC1 2 3 5 Protein Kinase A-Anchoring Protein 132 3 Lymphoid Blast Crisis Oncogene1 2 3 AKAP-132 3 AKAP-Lbc1 2 3 PRKA132 3 ARHGEF131 2 LBC Oncogene2 3 HA-31 2 P471 Ht311 2 HT313 5 PROTO-LB1 2 PROTO-LBC2 C-Lbc1 A-Kinase Anchor Protein 132 Breast Cancer Nuclear Receptor-Binding Auxiliary Protein2 3 A-Kinase Anchoring Protein2 Guanine Nucleotide Exchange Factor Lbc2 3
Export aliases for AKAP13 gene to outside databases Previous GC identifers: GC15M082290 GC15P079144 GC15P083511 GC15P083653 GC15P083724 GC15P083578 GC15P061986 GC15P085777
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Summariesfor AKAP13 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for AKAP13 : The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. (provided by RefSeq, Jul 2012) UniProtKB/Swiss-Prot: AKP13_HUMAN, Q12802 Function : Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13and Rho. Augments gene activation by the estrogen receptor in an element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions Gene Wiki entry for AKAP13
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Viewsfor AKAP13 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010274.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the AKAP13 gene promoter: Nkx3-1 AML1a Lmo2 Nkx3-1 v1 CUTL1 Meis-1b S8 Nkx6-1 Meis-1a Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for AKAP13 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat AKAP13
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q24-q25 Ensembl cytogenetic band: 15q25.3 HGNC cytogenetic band: 15q24-q25 AKAP13 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15P085925: view genomic region
(about GC identifiers )
Start:
85,923,802 bp from pter
End:
86,292,586 bp from pter
Size:
368,785 bases
Orientation:
plus strand
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Proteinsfor AKAP13 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: AKP13_HUMAN, Q12802 (See
protein sequence )Recommended Name: A-kinase anchor protein 13 Size : 2813 amino acids; 307550 Da
Subunit : Binds cAMP-dependent protein kinase (PKA) and to the RII-alpha regulatory subunit of PKA. Interacts with ESR1,ESR2, THRA, PPARA, RHOA and NME2
Subcellular location : Cytoplasm. Nucleus. Membrane
Sequence caution : Sequence=AAC50065.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAC50065.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAD21311.1; Type=Frameshift; Positions=2614, 2647; Sequence=AAD40799.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAD40799.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAL40923.1; Type=Frameshift; Positions=2614, 2647;
2 PDB 3D structures from and Proteopedia for AKAP13 :2DRN (3D)
  2LG1 (3D)
 
Secondary accessions : Q14572 Q59FP6 Q86W90 Q8WXQ6 Q96JP6 Q96P79 Q9Y5T0 Q9Y5T6Alternative splicing : 4 isoforms : Q12802-1 Q12802-2 Q12802-4 Q12802-5 Explore the universe of human proteins at neXtProt for AKAP13: NX_Q12802 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q12802 AKAP13 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001257475.1 NP_006729.4 NP_009131.2 ENSEMBL proteins: ENSP00000453768 ENSP00000453634 ENSP00000378026 ENSP00000354718 ENSP00000453620 ENSP00000452622 ENSP00000452698 ENSP00000453205 ENSP00000378018 Reactome Protein details: Q12802 Human Recombinant Protein Products: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
AKAP13 for ontologies About GeneDecksing AKAP13 Antibody Products: Assay Products for AKAP13:
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Protein
Domains / Familiesfor AKAP13 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
AKAP13 for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q12802 ProtoNet protein and cluster: Q12802
2 Blocks protein families : IPB000219 DH domain IPB001849 Pleckstrin-like UniProtKB/Swiss-Prot: AKP13_HUMAN, Q12802 Domain : Both the DH and PH domains are required for transforming activitySimilarity : Contains 1 DH (DBL-homology) domainSimilarity : Contains 1 PH domainSimilarity : Contains 1 phorbol-ester/DAG-type zinc finger
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Functionfor AKAP13 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: AKP13_HUMAN, Q12802 Function : Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13and Rho. Augments gene activation by the estrogen receptor in an element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions
Genatlas biochemistry entry for AKAP13 : A kinase (PRKA regulatory subunit RII) anchor protein 13 Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AKAP13 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AKAP13 (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): AKAP13 (NM_144767 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AKAP13 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AKAP13
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP13
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
AKAP13 for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for AKAP13 :Animal Models: 12 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Akap13) :
AKAP13 for phenotypes About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Pathways & Interactionsfor AKAP13 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/8 super-pathways (see all 8 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Cell death signalling via NRAGE, NRIF and NADE 2 Activation of cAMP-Dependent PKA 3 G Protein Signaling Pathways 4 Signaling by GPCR 5 Regulation of Water Balance by Renal Aquaporins
Pathway sources See GeneCards unified pathways Show all pathways 3 EMD Millipore Pathways for AKAP13 4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AKAP13 3 GeneGo (Thomson Reuters) Pathways for AKAP13 2 BioSystems Pathways for AKAP13 5/10
Reactome Pathways for AKAP13 (see all 10 )
AKAP13 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AKAP13 STRING Interaction
Network Preview (showing 5 interactants - click image to see 18)5/27 Interacting proteins for AKAP13 (Q12802 1 , 2 , 3 ENSP00000354718 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 27 )Interactant Interaction Details GeneCard External ID(s) YWHAB P31946 2 , 3 , ENSP00000300161 4 MINT-8006913 I2D:
score=5 STRING: ENSP00000300161 TGM2 P21980 1 , 3 , ENSP00000355330 4 EBI-1373806,EBI-727668 I2D:
score=1 STRING: ENSP00000355330 ESR1 P03372 1 , 3 , ENSP00000206249 4 EBI-1373806,EBI-78473 I2D:
score=3 STRING: ENSP00000206249 RHOA P61586 3 , ENSP00000400175 4 I2D:
score=4 STRING: ENSP00000400175 YWHAG P61981 3 , ENSP00000306330 4 I2D:
score=4 STRING: ENSP00000306330
About this table Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006915 apoptotic process
TAS -- GO:0007264 small GTPase mediated signal transduction
TAS -- GO:0035023 regulation of Rho protein signal transduction
IEA -- GO:0035556 intracellular signal transduction
-- -- GO:0048011 nerve growth factor receptor signaling pathway
TAS --
AKAP13 for ontologies About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Drugs & Compoundsfor AKAP13 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
AKAP13 for compounds About GeneDecksing Browse Tocris compounds for AKAP13 10/845 HMDB Compounds for AKAP13 (see all 845 ) About this table 10/24 Novoseek chemical compound relationships for AKAP13 gene (see all 24 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
cyclic amp
53.3
5
16540556 (1), 17081989 (1), 16460837 (1), 10074940 (1)
forskolin
36.5
3
10887192 (1), 12777250 (1)
threonine
27.6
3
17200117 (1), 11823486 (1), 16700649 (1)
calcium
23.8
11
9620705 (2), 11258666 (1), 15652351 (1), 9545239 (1) (see all 6 )
serine
20.6
3
17200117 (1), 11823486 (1), 16700649 (1)
ryanodine
18.2
3
12709444 (1), 11258666 (1), 15652351 (1)
potassium
15.8
5
15710486 (1), 11287423 (1), 16647783 (1), 16002409 (1) (see all 5 )
isoproterenol
14
1
11731570 (1)
gdp
13.6
4
8910315 (3), 11696353 (1)
gtp
7.02
1
11696353 (1)
Search CenterWatch for drugs/clinical trials and news about AKAP13 / AKP13
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Transcriptsfor AKAP13 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for AKAP13 gene (4 alternative transcripts): NM_001270546.1 NM_006738.5 NM_007200.4 NM_144767.3 Unigene Clusters for AKAP13:
A kinase (PRKA) anchor protein 13 Hs.459211 [show with all ESTs ] , Hs.710656 [show with all ESTs ] Unigene Representative Sequences: NM_006738 , AK022014 18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24 ): ENST00000560571 ENST00000559362 (uc002blt.1 ) ENST00000560302 (uc002bls.3 )ENST00000394518 (uc002blu.1 uc002blv.1 uc010bne.1 uc002blw.1 )ENST00000361243 ENST00000560256 ENST00000558166 ENST00000558811 ENST00000561337 ENST00000560340 ENST00000560676 (uc010bnf.1 ) ENST00000560579 ENST00000559486 ENST00000560957 ENST00000558092 ENST00000557852 ENST00000560482 ENST00000559278 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AKAP13 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AKAP13 (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): AKAP13 (NM_144767 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AKAP13 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AKAP13
Additional cDNA sequence: AK022014.1
24/32 DOTS entries (see all 32 ): DT.95104508 DT.95291719
DT.100795176 DT.40214988 DT.95298158 DT.100795183 DT.307348 DT.86857503 DT.100686517 DT.100713955 DT.121018027 DT.121018104 DT.99941659 DT.75170979 DT.97770739 DT.92453875 DT.92453880 DT.95275310 DT.100032362 DT.100646339 DT.121018025 DT.121018132 DT.40263503 DT.70105049 24/60 AceView cDNA sequences (see all 60 ):
BQ225311 AI885889 R82598 BM129627 AA835490 CA416389 AI864082 AI679155 AW440054 BM673486 CA424347 T40618 BM969106 BQ021860 BM707378 N41455 T50096 AA704565 BM129808 N77147 C01311 AA332594 BG011313 AI955468 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for AKAP13 (see all 6 ) About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ SP1 :           -                     -   -                     SP2 :                                 -                     SP3 :                                                     SP4 :                                                     SP5 :                                                    
ExUns: 22a · 22b ^ 23 SP1 :       SP2 :       SP3 :       SP4 :       SP5 :      
ECgene alternative splicing isoforms for AKAP13
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Expression for AKAP13 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section AKAP13 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGATGCGCAG
About this image AKAP13 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Reproductive System Early Gonad Testis Somatic Cells Testis Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See AKAP13 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for AKAP13 SOURCE GeneReport for Unigene clusters: Hs.459211 Hs.710656 UniProtKB/Swiss-Prot: AKP13_HUMAN, Q12802 Tissue specificity : Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart,estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle SABiosciences Custom PCR Arrays for AKAP13 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for AKAP13Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat AKAP13 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat AKAP13 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat AKAP13 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP13
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Orthologsfor AKAP13 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for AKAP13 gene from 3/15 species (see all 15 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
AKAP131
A kinase (PRKA) anchor protein 13
69.78(n) 68.05(a)
 
415502 XM_413874.3 XP_413874.3
zebrafish (Danio rerio)
Actinopterygii
wu:fi40d091
wu:fi40d09
50.25(n) 42.14(a)
 
556620 XM_679462.5 XP_684554.5
fruit fly (Drosophila melanogaster)
Insecta
CG101883
Rho guanyl-nucleotide exchange factor
30(a)
 
--
ENSEMBL Gene Tree for AKAP13 (if available)TreeFam Gene Tree for AKAP13 (if available)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Paralogsfor AKAP13 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for AKAP13 gene ARHGEF2 2 ARHGEF3 2 ARHGEF12 2 ARHGEF11 2 ARHGEF18 2 ARHGEF28 2 NET1 2 ARHGEF1 2 5 SIMAP similar genes for AKAP13 using alignment to 8 protein entries: AKP13_HUMAN (see all proteins ):ARHGEF28 RGNEF ARHGEF18 ARHGEF2 ARHGEF1
AKAP13 for paralogs About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Variantsfor AKAP13 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 15 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for AKAP13 (85923802 - 86173802 bp, first 250kb of AKAP13)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 16 variations for AKAP13 14 CNVs : 5800 66860 34473 7077 66859 8802 49606 49607 87814 77055 34474 102151 53215 43437 2 Indels : 49605 41376 Human Gene Mutation Database (HGMD) : AKAP13 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing AKAP13
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Disorders
/ Diseasesfor AKAP13 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
AKAP13 for disorders About GeneDecksing
OMIM gene information: 604686
OMIM disorders : --17 diseases for AKAP13 : About MalaCards breast cancer long qt syndrome thyroiditis relapsing fever mantle cell lymphoma cystic fibrosis familial breast cancer fibrosis astrocytoma prostate cancer spasticity alzheimer's disease endometriosis colorectal cancer prostatitis leukemia neuronitis 2 diseases from the University of Copenhagen DISEASES database for AKAP13 :Relapsing fever Cervical cancer 8 Novoseek disease relationships for AKAP13 gene About this table
Genetic Association Database (GAD): AKAP13 Human Genome Epidemiology (HuGE) Navigator: AKAP13 (9 documents) Export disorders for AKAP13 gene to outside databases
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Publicationsfor AKAP13 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for AKAP13 gene, integrated from 9 sources (see all 236 ): (articles sorted by number of sources associating them with AKAP13) Utopia : connect your pdf to the dynamic world of online information
Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action. (PubMed id 9627117) 1 , 2 , 3, 9 Rubino D.... Segars J. (1998) Lbc proto-oncogene product binds to and could be negatively regulated by metastasis suppressor nm23-H2. (PubMed id 15249197) 1 , 2 , 9 Iwashita S.... Miyamoto M. (2004) Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. (PubMed id 11696353) 1 , 2 , 9 Klussmann E.... Rosenthal W. (2001) Association of genetic variants in the Rho guanine nucleotide exchange factor AKAP13 with familial breast cancer. (PubMed id 16234258) 1 , 4, 9 Wirtenberger M....Burwinkel B. (2006) Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products. (PubMed id 8290273) 1 , 2 , 9 Toksoz D. and Williams D.A. (1994) AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation. (PubMed id 11546812) 1 , 2 , 9 Diviani D.... Scott J.D. (2001) A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243) 1 , 2 Beausoleil S.A.... Gygi S.P. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 Olsen J.V....Mann M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway. (PubMed id 11579095) 1 , 2 Driggers P.H.... Rubino D.M. (2001)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
External Searches for AKAP13 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genome Databases showing AKAP13 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Other Databases showing AKAP13 gene
(According to HUGE )
About This Section --
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Specialized Databases showing AKAP13 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
About This Section Patent Information for AKAP13 gene: Search GeneIP for patents involving AKAP13 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Productsfor AKAP13 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for AKAP13 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for AKAP13 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for AKAP13 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for AKAP13 OriGene 3'-UTR Clone for AKAP13 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AKAP13 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AKAP13 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for AKAP13 OriGene Custom Protein Services for AKAP13 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AKAP13 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing AKAP13 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat AKAP13 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat AKAP13 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat AKAP13 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat AKAP13
Search Tocris compounds for AKAP13
AKAP13 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP13
Search ThermoFisher Antibodies for AKAP13
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AKAP13
Jump to Section...
Aliases for AKAP13
Databases for AKAP13
Disorders / Diseases for AKAP13
Domains / Families for AKAP13
Drugs / Compounds for AKAP13
Expression for AKAP13
Function for AKAP13
Genomic Views for AKAP13
Intellectual Property for AKAP13
Orthologs for AKAP13
Paralogs for AKAP13
Pathways / Interactions for AKAP13
Products for AKAP13
Proteins for AKAP13
Publications for AKAP13
Search Box for AKAP13
Summaries for AKAP13
Transcripts for AKAP13
Variants for AKAP13
TOP
BOTTOM