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AKAP13 Gene

protein-coding   GIFtS: 66

GC15P083724
A kinase (PRKA) anchor protein 13
(Previous name: lymphoid blast crisis oncogene )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: LBC)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
AKAP-Lbc 1, 2, 3
ARHGEF13 1, 2
BRX 1, 2, 3, 5
FLJ11952 2
FLJ43341 2
HA-3 1, 2
HT31 3, 5
Ht31 1, 2
LBC 2, 3, 5
P47 3
PROTO-LB 1, 2
PROTO-LBC 2
c-lbc 1, 2
Descriptions
A kinase (PRKA) anchor protein 13 2
A kinase anchor protein 13 1
A-kinase anchor protein 13 2
A-kinase anchoring protein 2
AKAP 13 3
Breast cancer nuclear receptor-binding auxiliary protein 2, 3
Guanine nucleotide exchange factor Lbc 2, 3
Human thyroid-anchoring protein 31 3
LBC oncogene 3
Lymphoid blast crisis oncogene 1, 2, 3
Non-oncogenic Rho GTPase-specific GTP exchange factor 3
Protein kinase A-anchoring protein 13 3
External Ids
HGNC: 3711
Entrez Gene: 112142
UniProtKB: Q128023
Ensembl: ENSG000001707767
Search outside databases for aliases for AKAP13 gene

Previous GC identifers: GC15M082290 GC15P079144 GC15P083511 GC15P083653 GC15P083578

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AKAP13:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the
common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the
holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family.
Alternative splicing of this gene results in at least 3 transcript variants encoding different
isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The
DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of
small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form
capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms
function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function
as protein kinase A-anchoring proteins. [provided by RefSeq]

UniProtKB/Swiss-Prot: AKP13_HUMAN, Q12802
Function: Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively
couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an
element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38
MAPK-dependent pathway. Isoform 6 stimulates exchange activity on Rho proteins in vitro, but not
on CDC42, Ras or Rac and may bind calcium ions

Gene Wiki entry for AKAP13

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the AKAP13 gene  

Entrez Gene cytogenetic band: 15q24-q25   Ensembl cytogenetic band:  15q25.3   HGNC cytogenetic band: 15q24-q25

AKAP13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P083724:     (about GC identifiers)

Start:
83,724,875 bp from pter
End:
84,093,590 bp from pter
Size:
368,716 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000015.8  NT_010274.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AKP13_HUMAN, Q12802 (See protein sequence)
Recommended Name: A-kinase anchor protein 13  
Size: 2813 amino acids; 307550 Da
Subunit: Binds cAMP-dependent protein kinase (PKA) and to the RII-alpha regulatory subunit of PKA.
Interacts with ESR1, ESR2, THRA, PPARA, RHOA and NME2
Subcellular location: Isoform 3: Cytoplasm. Nucleus
Subcellular location: Isoform 2: Cytoplasm
Subcellular location: Isoform 6: Cytoplasm
Subcellular location: Isoform 7: Membrane
Sequence caution: Sequence=AAD21311.1; Type=Frameshift; Positions=2614, 2647; Sequence=AAL40923.1;
Type=Frameshift; Positions=2614, 2647;
PDB structures from and Proteopedia :
2DRN (3D)    
Secondary accessions: Q14572 Q59FP6 Q86W90 Q8WXQ6 Q96JP6 Q96P79 Q9Y5T0 Q9Y5T6
Alternative splicing: 7 isoforms:  Q12802-1   Q12802-2   Q12802-3   Q12802-4   Q12802-5   Q12802-6   Q12802-7   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_006729.4  NP_009131.2  NP_658913.1  


    ENSEMBL proteins: 
    ENSP00000378024 ENSP00000378026 ENSP00000378018 ENSP00000354718 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (AKAP13)
    Human Recombinant Proteins from Abnova (AKAP13)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575 cellular_component ND--
    GO:0005622 intracellular IEA--
    GO:0005624 membrane fraction TAS9891067
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for AKAP13: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of AKAP13
    Sigma-Aldrich Antibodies for AKAP13
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (AKAP13), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (AKAP13)
    Novus Biologicals Antibodies for AKAP13

    Assays for AKAP13: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/7 InterPro domains/families (see all 7 ):
     IPR018459 RII_binding_1
     IPR001331 GDS_CDC24_CS
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR002219 DAG_PE_bd


       GeneDecks  AKAP13 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q12802

    ProtoNet protein and cluster: Q12802

    2 Blocks protein families:
    IPB000219 DH domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: AKP13_HUMAN, Q12802
    Domain: Both the DH and PH domains are required for transforming activity
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (AKAP13)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AKAP13)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_144767

                  Applied Biosystems Silencer® siRNAs for AKAP13

                  Sigma-Aldrich siRNA and siRNA Panels for AKAP13  
                         Sigma-Aldrich shRNA for AKAP13  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for AKAP13
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_006738
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_006738
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_006738 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_006738

    UniProtKB/Swiss-Prot: AKP13_HUMAN, Q12802
    Function: Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively
    couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an
    element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38
    MAPK-dependent pathway. Isoform 6 stimulates exchange activity on Rho proteins in vitro, but not
    on CDC42, Ras or Rac and may bind calcium ions

    Genatlas biochemistry entry for AKAP13:
    A kinase (PRKA regulatory subunit RII) anchor protein 13

    5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004691 cAMP-dependent protein kinase activity NAS1618839
    GO:0004871 signal transducer activity TAS8290273
    GO:0005085 guanyl-nucleotide exchange factor activity IEA--
    GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515 protein binding IPI16301118 17353931
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    3 Invitrogen iPath™ Online BioAtlas - Pathways for AKAP13 (Maps provided by GeneGo):
     Ligand- dependent and ligand-independent activation of estrogen receptors
     G-Protein alpha-12 signaling pathway
     Estrogen receptor signaling pathway

       GeneDecks  AKAP13 for the pathways selected above  
    About GeneDecksing

    3 Millipore Pathways for AKAP13
     Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
     G-protein signaling G-Protein alpha-12 signaling pathway
     Signal transduction PKA signaling

       GeneDecks  AKAP13 for the pathways selected above  
    About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  AKAP13  (Your Favorite Gene powered by Ingenuity) 
     Cardiac &beta
     cAMP-mediated Signaling

       GeneDecks  AKAP13 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  AKAP13 


    5/100 Interacting proteins for AKAP13 (Q128021 ENSP000003547183) via UniProtKB, MINT, and/or STRING (see all 100 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319461, ENSP000003619303EBI-1373806, EBI-359815 STRING (score=.753)
    BAK1Q166111EBI-1373806, EBI-519866
    TGM2P219801EBI-1373806, EBI-727668
    PRKAR2AENSP000002655633STRING (score=.976)
    CDC42P2ENSP000003144583STRING (score=.975)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007242 intracellular signaling cascade IEA--
    GO:0008150 biological_process ND--
    GO:0035023 regulation of Rho protein signal transduction IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for AKAP13
    10/16 Novoseek chemical compound relationships for AKAP13 gene (see all 16 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 51.98 5 16540556 (1), 17081989 (1), 16460837 (1), 10074940 (1)
    forskolin 38.12 3 10887192 (1), 12777250 (1)
    threonine 26.07 3 17200117 (1), 11823486 (1), 16700649 (1)
    calcium 20.65 11 9620705 (2), 11258666 (1), 15652351 (1), 9545239 (1) (see all 6)
    ryanodine 20.29 3 12709444 (1), 11258666 (1), 15652351 (1)
    gdp 15.83 4 8910315 (3), 11696353 (1)
    potassium 10.33 5 15710486 (1), 11287423 (1), 16647783 (1), 16002409 (1) (see all 5)
    gtp 8.99 1 11696353 (1)
    tyrosine 3.84 3 15342355 (1), 17200117 (1), 12509440 (1)
    atp 0.00 1 10600928 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (AKAP13)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AKAP13)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_144767

                  Sigma-Aldrich siRNA and siRNA Panels for AKAP13  
                         Sigma-Aldrich shRNA for AKAP13  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_006738  NM_007200  NM_144767  

    REFSEQ mRNAs for AKAP13 gene (3 alternative transcripts): 

    NM_006738.4   NM_007200.3   NM_144767.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_006738  NM_007200  NM_144767  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_006738
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_006738
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_006738 

    Additional cDNA sequence: AK022014.1 

    24/35 DOTS entries (see all 35 ):

    DT.95104508  DT.100795176  DT.95291719  DT.40214988  DT.95298158  DT.100795183  DT.75170979  DT.307348 
    DT.86857503  DT.100686517  DT.100713955  DT.121018027  DT.121018104  DT.99941659  DT.100685917  DT.97770739 
    DT.92453875  DT.92453880  DT.95275310  DT.100032362  DT.100646339  DT.121018025  DT.121018132  DT.40263503 

    24/60 AceView cDNA sequences (see all 60 ):

    BQ225311 AW440054 AI679155 BM673486 CA424347 CA416389 BM129627 R82598 
    AA835490 AI864082 BM969106 AI885889 T40618 BM707378 T50096 N41455 
    BM129808 AA704565 BQ021860 AA332594 C01311 AA029344 N29395 AW794724 

    highest scoring ESTs for AKAP13:

    AA029344 AA534713 AI674926 AA029343 AA040150 AA113166 AA312928 AA332594 AA347605 AA347723 

    Unigene Clusters for AKAP13:

    A kinase (PRKA) anchor protein 13
    Hs.459211  [show with all ESTs], Hs.710656  [show with all ESTs]
    Unigene Representative Sequences: NM_006738, AK022014


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for AKAP13 (see all 6 )

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                                -                                                           -     -                                                         
    SP2:                                                                                                  -                                                         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22a · 22b ^ 23
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  

    About this scheme

    ECgene alternative splicing isoforms for AKAP13

    4 Ensembl transcripts including schematic representations:
    ENST00000394516  ENST00000394518  ENST00000394510  ENST00000361243  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    AKAP13 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for AKAP13

    1 / 2 / 3

    26 probe-sets matching AKAP13 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    53972_at2, 3 U95-B 1 1.00 1.00 0.19 0.32 AA044176 0.60 1.00 0.82 1

    45330_at2, 3 U95-B 1 1.00 1.00 0.92 1.55 AA534713 1.00 1.00 1.00 1
    62466_at2, 3 U95-C 1 1.00 1.00 0.29 0.57 AI797853 0.80 1.00 0.91 1

    735_s_at2, 3 U95-A 1 1.00 1.00 0.12 0.35 HG2167-HT2237 0.20 1.00 0.72 1
    45861_at2, 3 U95-B 1 1.00 1.00 0.75 0.98 AI674926 1.00 1.00 1.00 1

    44769_at2, 3 U95-B 1 1.00 1.00 0.94 1.49 AA029344 1.00 1.00 1.00 1

    89813_at2, 3 U95-E 1 0.94 1.00 0.64 0.85 AW014130 0.80 1.00 0.91 1

    554_at2, 3 U95-A 2 0.50 0.89 0.43 0.59 U03634 0.40 1.00 0.76 1

    222023_at2, 3 U133-A 1 1.00 1.00 -- -- AK022014 0.60 1.00 0.82 1

    222024_s_at2, 3 U133-A 1 1.00 1.00 -- -- AK022014 0.60 1.00 0.82 1

    224884_at2, 3 U133-B 1 1.00 1.00 -- -- AW575773 0.80 1.00 0.91 1

    221718_s_at2, 3 U133-A 1 1.00 1.00 -- -- M90360 0.60 1.00 0.82 1

    227039_at2, 3 U133-B 1 1.00 1.00 -- -- AI674926 1.00 1.00 1.00 1

    209534_x_at2, 3 U133-A 1 1.00 1.00 -- -- BF222823 0.40 1.00 0.76 1

    208325_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006738 0.60 1.00 0.82 1

    209535_s_at*2, 3 U133-A 1 1.00 1.00 -- -- AF127481 0.40 1.00 0.76 1

    232188_at*2, 3 U133-B NULL 0.00 0.00 -- -- AL133427 0.40 1.00 0.76 1

    222023_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    222024_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    224884_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    221718_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    227039_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    209534_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    208325_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    209535_s_at*2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    232188_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
    GeneDecks  AKAP13 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTTATAGATA

    SOURCE GeneReport for Unigene clusters: Hs.459211 Hs.710656

    Expression variation in blood from EXPOLDB for AKAP13

    UniProtKB/Swiss-Prot: AKP13_HUMAN, Q12802
    Tissue specificity: Isoform 3 and isoform 6 are found in hematopoietic cells, skeletal muscle,
    lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also
    found in testis and breast cancer cell lines. Isoform 6 is not found in brain, placenta, liver,
    pancreas or kidney. Isoform 7 is expressed in myeloid and lymphoid lineages, a variety of
    epithelial tissues and skeletal muscle. Isoform 2 is predominantly found in the heart and at lower
    levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for AKAP13 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    AKAP131   -- A kinase (PRKA) anchor protein 13 83.93(n)
    78.96(a)
    479032  XM_536182.2  XP_536182.2 
    chimpanzee
    (Pan troglodytes)
    AKAP131   -- A kinase (PRKA) anchor protein 13 99.38(n)
    99.14(a)
    743772  XM_001163760.1  XP_001163760.1 
    mouse
    (Mus musculus)
    Akap131, 5 75
    A kinase (PRKA) anchor protein 131, 5 80.1(n)1
    74.9(a)1
    755471  XM_133543.71  XP_133543.71 
     AK0063825  AK0180235  (see all 23)
    chicken
    (Gallus gallus)
    AKAP131   -- A kinase (PRKA) anchor protein 13 70.06(n)
    68.49(a)
    415502  XM_413874.2  XP_413874.2 
    zebrafish
    (Danio rerio)
    wu:fi40d091   -- wu:fi40d09 49.71(n)
    41.39(a)
    556620  XM_679462.3  XP_684554.3 
    About this table        Species with no ortholog for AKAP13

    ENSEMBL Gene Tree for AKAP13
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for AKAP13 gene
    ENSG000002149442  ARHGEF22  ARHGEF182  ENSG000000381022  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/2520 NCBI SNPs in AKAP13 are shown (see all 2520 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 817)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs10539921,2
    A,C,F,H,O84089522(+) CACCCG/CTGTTT 3 -- ut31 ese38Minor allele frequency- C:0.38MN NA EU EA WA 742
    rs18083391,2
    A,C,F,H,O84089271(-) AGGCAG/TTCGGA 3 -- ut3111Minor allele frequency- T:0.35EA NA EU WA 908
    rs20618221,2
    A,C,F,H,O83923783(+) CTGTTC/TGGAAG 2 W/R mis113Minor allele frequency- T:0.39EU EA WA NA 1118
    rs8706891,2
    A,C,F,H,O84092261(-) TCCCAC/TCCTCT 3 -- ut31 ese313Minor allele frequency- T:0.30MN EU EA WA NA 2066
    rs20618211,2
    A,C,F,H,O83923658(+) GGTCAC/TGGAGC 2 M/T mis18Minor allele frequency- T:0.39EU EA WA 838
    rs20618241,2
    A,C,F,H,O83924023(+) GAAGTT/CGTGAG 2 C/R mis19Minor allele frequency- C:0.39EU EA WA NA 902
    rs71739231,2
    A,C,F,H84093475(+) CGAATT/ATTGCC 3 -- ut3112Minor allele frequency- A:0.12MN EU EA WA NA 1164
    rs26146661,2
    A,C,F,H84093026(-) CGGTGG/ACAGGG 3 -- ut31 ese37Minor allele frequency- A:0.22NA EU EA WA 562
    rs7451911,2
    A,C,F,H83924174(+) TCTTGG/TGCTGG 2 G/V mis1 ese39Minor allele frequency- T:0.11EU EA WA NA 904
    rs3385151,2
    C,F,H,O84019771(-) GTACGG/CAAAAG 3 -- int1 ng5111Minor allele frequency- C:0.27EU EA WA NA 980
    About this table

    HapMap Linkage Disequilibrium images for AKAP13 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 604686

    7 Novoseek disease relationships for AKAP13 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    cystic fibrosis 7.19 1 10600928 (1)
    cancer 2.34 5 16234258 (2), 15059896 (1)
    tumors 1.85 1 17577780 (1)
    colon cancer 0.00 1 15059896 (1)
    breast cancer 0.00 3 16412732 (2), 16234258 (1)
    prostate cancer 0.00 3 16301118 (2)
    astrocytoma 0.00 1 11278452 (1)
    About this table

    Human Gene Mutation Database: AKAP13
    Genetic Association Database: AKAP13
    Human Genome Epidemiology Navigator: AKAP13 (4 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/197 PubMed articles for AKAP13 gene (see all 197 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 11214 HGNC: 371 AceView: AKAP13.1 Ensembl:ENSG00000170776 euGenes: HUgn11214
    ECgene: AKAP13 H-InvDB: AKAP13
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for AKAP13 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



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