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AKAP12 Gene

protein-coding   GIFtS: 63

GC06P151653
A kinase (PRKA) anchor protein 12
(Previous name: A kinase (PRKA) anchor protein (gravin) 12 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for AKAP12

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
AKAP250 1, 2, 3
DKFZp686M0430 2
DKFZp686O0331 2
FLJ20945 2
FLJ97621 2
Gravin 3
OTTHUMP00000017426 2
Descriptions
A kinase (PRKA) anchor protein (gravin) 12 1, 2
A kinase (PRKA) anchor protein 12 2
A kinase anchor protein 12 1
A-kinase anchor protein 250 kDa 3
A-kinase anchor protein, 250kDa 2
AKAP 250 3
Myasthenia gravis autoantigen 3
kinase scaffold protein gravin 2
myasthenia gravis autoantigen gravin 2
External Ids
HGNC: 3701
Entrez Gene: 95902
UniProtKB: Q029523
Ensembl: ENSG000001310167
Search outside databases for aliases for AKAP12 gene

Previous GC identifers: GC06P151122 GC06P151456 GC06P151592

Summaries
for AKAP12

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for AKAP12:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the
common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the
holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family.
The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma
cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold
protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This
protein is a cell growth-related protein. Antibodies to this protein can be produced by patients
with myasthenia gravis. Alternative splicing of this gene results in two transcript variants
encoding different isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: AKA12_HUMAN, Q02952
Function: Anchoring protein that mediates the subcellular compartmentation of protein kinase A
(PKA) and protein kinase C (PKC)

Gene Wiki entry for AKAP12

Genomic Location
for AKAP12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the AKAP12 gene  

Entrez Gene cytogenetic band: 6q24-q25   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q24-q25

AKAP12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P151653:     (about GC identifiers)

Start:
 151,603,202 bp from pter
End:
 151,719,602 bp from pter
Size:
 116,401 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000006.10  NT_025741.14  

Proteins
for AKAP12

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: AKA12_HUMAN, Q02952 (See protein sequence)
Recommended Name: A-kinase anchor protein 12  
Size: 1782 amino acids; 191483 Da
Subunit: Binds to dimeric RII-alpha regulatory subunit of PKC
Subcellular location: Cytoplasm, cell cortex (Probable). Cytoplasm, cytoskeleton (Probable).
Note=May be part of the cortical cytoskeleton
Secondary accessions: O00310 O00498 Q4LE68 Q5SZ80 Q5TGN1 Q68D82 Q99970
Alternative splicing: 3 isoforms:  Q02952-1   Q02952-2   Q02952-3   

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_005091.2  NP_653080.1  


    ENSEMBL proteins: 
    ENSP00000253332 ENSP00000384537 ENSP00000346702 ENSP00000352794 ENSP00000376073 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (AKAP12)
    Human Recombinant Proteins from Abnova (AKAP12)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA18029348
    GO:0005737 cytoplasm TAS10858453
    GO:0005856 cytoskeleton IEA--
    GO:0005886 plasma membrane IDA18029348
    About this table

    Antibodies for AKAP12: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for AKAP12
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (AKAP12), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (AKAP12)
    Novus Biologicals Antibodies for AKAP12

    Assays for AKAP12: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for AKAP12

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro domains/families:
     IPR018459 RII_binding_1
     IPR001573 Pkinase-A_anch_WSK-motif


       GeneDecks  AKAP12 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q02952

    ProtoNet protein and cluster: Q02952

    1 Blocks protein family: IPB001573 Protein kinase A anchoring domain

    UniProtKB/Swiss-Prot: AKA12_HUMAN, Q02952
    Domain: Polybasic regions located between residues 266 and 557 are involved in binding PKC
    Similarity: Contains 3 AKAP domains

    Gene Function
    for AKAP12

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (AKAP12)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AKAP12)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005100

                  Applied Biosystems Silencer® siRNAs for AKAP12

                  Sigma-Aldrich siRNA for AKAP12  
                         Sigma-Aldrich shRNA Panels and shRNA for AKAP12  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for AKAP12
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005100
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005100
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_005100 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005100

    UniProtKB/Swiss-Prot: AKA12_HUMAN, Q02952
    Function: Anchoring protein that mediates the subcellular compartmentation of protein kinase A
    (PKA) and protein kinase C (PKC)
    Induction: Activated by lysophosphatidylcholine (lysoPC)

    Genatlas biochemistry entry for AKAP12:
    A kinase (PRKA regulatory subunits PRKC and RIIA) anchor protein 12,expressed in endothelial cells
    and several adherent cells

    1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Akap12):

    normal

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051018 protein kinase A binding TAS10858453
    About this table

    Pathways & Interactions
    for AKAP12

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for AKAP12
     Signal transduction PKA signaling

       GeneDecks  AKAP12 for the pathways selected above  
    About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  AKAP12  (Your Favorite Gene powered by Ingenuity) 
     Cardiac &beta
     cAMP-mediated Signaling

       GeneDecks  AKAP12 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  AKAP12 


    5/15 Interacting proteins for AKAP12 (Q029522 ENSP000002533323) via UniProtKB, MINT, and/or STRING (see all 15 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAR2AP138612, ENSP000002655633MINT-2411858 STRING (score=.964)
    PDE4DQ084992, ENSP000003455023MINT-2411838 STRING (score=.833)
    PRKCAENSP000002843843STRING (score=.957)
    SRCENSP000003626593STRING (score=.937)
    ADRB2ENSP000003053723STRING (score=.924)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006605 protein targeting IEA--
    GO:0007165 signal transduction IEA--
    GO:0007186 G-protein coupled receptor protein signaling pathway TAS10858453
    About this table

    Drugs & Compounds
    for AKAP12

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for AKAP12
    1 Novoseek chemical compound relationship for AKAP12 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 1.18 1 14715081 (1)
    About this table


    Transcripts
    for AKAP12

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (AKAP12)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AKAP12)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005100

                  Sigma-Aldrich siRNA for AKAP12  
                         Sigma-Aldrich shRNA Panels and shRNA for AKAP12  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005100  NM_144497  

    REFSEQ mRNAs for AKAP12 gene (2 alternative transcripts): 

    NM_005100.3   NM_144497.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005100  NM_144497  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005100
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005100
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_005100 

    Additional cDNA sequence: 

    AB003476.1 AB210003.1 AF001504.1 AF086250.1 AK024598.1 AK126161.1 AK307578.1 AK307673.1 
    AK307739.1 BC000188.1 BC015830.1 BC022814.1 BC033829.1 BC047728.1 BC070151.1 BC117679.1 
    BC117680.1 CR619037.1 CR749527.1 CR936604.1 M96322.1 U81607.1 

    14 DOTS entries:

    DT.95170629  DT.100823862  DT.97843539  DT.100823860  DT.87016407  DT.75106825  DT.91650893  DT.75138132 
    DT.100031427  DT.40132830  DT.100680885  DT.97800929  DT.121362334  DT.95170641 

    24/362 AceView cDNA sequences (see all 362 ):

    BM697257 AI656759 AA570647 CB158171 BM996222 BM679663 AB003476 BQ919238 
    BQ772759 AA699718 BQ432119 NM_144497 CR619037 AL040086 BQ221404 BM721250 
    CB160154 BU735937 BM729126 BX492672 CA390252 BG112901 BF339175 AI078016 

    highest scoring ESTs for AKAP12:

    U81607 AA010248 AA010249 AA024796 AA032141 AA092037 AA101138 AA146779 AA148133 AA470106 

    Unigene Cluster for AKAP12:

    A kinase (PRKA) anchor protein 12
    Hs.371240  [show with all ESTs]
    Unigene Representative Sequence: NM_005100


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AKAP12 (see all 7 )

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b
    SP1:        -                             -     -     -     -                                 
    SP2:                                      -     -     -     -                                 
    SP3:                                                                                          
    SP4:                                      -     -     -     -     -     -     -               
    SP5:                                                        -                                 

    About this scheme

    ECgene alternative splicing isoforms for AKAP12

    5 Ensembl transcripts including schematic representations:
    ENST00000253332  ENST00000402676  ENST00000354675  ENST00000359755  ENST00000392241  

    Expression
    for AKAP12

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    AKAP12 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for AKAP12

    1 / 2 / 3

    11 probe-sets matching AKAP12 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		82404_s_at2, 3 U95-E 1 1.00 1.00 0.97 0.60 AA037161 0.40 1.00 0.76 1

    		82406_r_at2, 3 U95-E 1 1.00 1.00 0.94 0.73 AA037161 0.40 1.00 0.76 1
    49825_at2, 3 U95-C 1 1.00 1.00 0.98 1.70 AI806221 0.40 1.00 0.76 1

    		37680_at2, 3 U95-A 2 1.00 0.97 0.82 1.16 U81607 1.00 0.90 0.95 1

    		227529_s_at2, 3 U133-B 1 1.00 1.00 -- -- BF511276 0.40 1.00 0.76 1

    		227530_at2, 3 U133-B 1 1.00 1.00 -- -- BF511276 0.40 1.00 0.76 1

    		210517_s_at2, 3 U133-A 1 1.00 1.00 -- -- AB003476 0.80 1.00 0.91 1

    		1555395_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		227529_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		227530_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		210517_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  AKAP12 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AGTTGCCTCT

    SOURCE GeneReport for Unigene cluster: Hs.371240

    Expression variation in blood from EXPOLDB for AKAP12

    UniProtKB/Swiss-Prot: AKA12_HUMAN, Q02952
    Tissue specificity: Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not
    in platelets, leukocytes, monocytic cell lines or peripherical blood cells

    Orthologs
    for AKAP12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for AKAP12 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 AKAP121   -- A kinase (PRKA) anchor protein 12 77.07(n)
    69.03(a)    		 476246  XM_533451.2  XP_533451.2 
    cow
    (Bos taurus)    		 AKAP121   -- A kinase (PRKA) anchor protein 12 74.12(n)
    66.23(a)    		 513774  XM_591518.3  XP_591518.3 
    rat
    (Rattus norvegicus)    		 Akap121   -- A kinase (PRKA) anchor protein 12 70.92(n)
    61.42(a)    		 83425  NM_001033653.1  NP_001028825.1 
    mouse
    (Mus musculus)    		 Akap121, 5 105
    		 A kinase (PRKA) anchor protein (gravin) 121, 5 71.18(n)1
    61.28(a)1    		 833971  NM_031185.21  NP_112462.11 
     AB0208865  AB0252785  (see all 21)
    chicken
    (Gallus gallus)    		 AKAP121   -- A kinase (PRKA) anchor protein (gravin) 12 53.2(n)
    43.18(a)    		 421634  XM_419673.2  XP_419673.2 
    About this table        Species with no ortholog for AKAP12

    ENSEMBL Gene Tree for AKAP12

    Paralogs
    for AKAP12

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for AKAP12 gene
    TCOF12  NOLC12  

    SNPs/Variants
    for AKAP12

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/965 NCBI SNPs in AKAP12 are shown (see all 965 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 278)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs92061,2
    		A,C,F,H,O151720891(+) TATCTA/GTGTCC 2 -- ut319Minor allele frequency- G:0.48MN NA EU EA WA 930
    rs22488611,2
    		A,C,F,H,O151687262(-) GTTGCG/ACTTTT 2 -- int1 ng5114Minor allele frequency- A:0.31EA NA EU WA 2660
    rs24855431,2
    		A,C,F,H,O151687978(+) CAGTCC/TTCAGA 2 -- int1 ng517Minor allele frequency- T:0.42NA EU EA WA 542
    rs77570021,2
    		A,C,F,H151688324(+) CGGGGG/AAGGGC 2 -- int1 ng518Minor allele frequency- A:0.13EU EA WA 836
    rs9604661,2
    		A,C,F,H151601545(+) AAACTC/GCAGAG 1 -- ng518Minor allele frequency- G:0.23EU EA WA 838
    rs37347991,2
    		A,C,F,H151711865(-) GTCCTG/TGTGGT 2 K/Q mis1 ese311Minor allele frequency- T:0.41EA EU WA NA 2302
    rs22977781,2
    		A,C,F,H151686771(-) GTCCCT/CTCCCC 2 -- int1 ng51 trp39Minor allele frequency- C:0.35EA EU WA 1908
    rs37347951,2
    		A,C,F,H151716286(-) GACTTC/ATCTAT 2 D/E mis1 ese317Minor allele frequency- A:0.13EA NS EU WA NA 2576
    rs65571301,2
    		A,C,F,H151718601(+) AGTAGT/CAGAAG 2 -- ut317Minor allele frequency- C:0.06EU EA WA NA 558
    rs38233101,2
    		A,C,F,H151716019(-) TGAGGT/GTCCTC 2 D/E mis1 ese3 trp312Minor allele frequency- G:0.47EA NA EU WA 1052
    About this table

    HapMap Linkage Disequilibrium images for AKAP12 (up to first 250kb)

    Disorders & Mutations
    for AKAP12

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 604698

    UniProtKB/Swiss-Prot: AKA12_HUMAN, Q02952
  • Antibodies to the C-terminal of gravin can be produced by patients with myasthenia gravis
    (MG)

    • 2 Novoseek disease relationships for AKAP12 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 5.37 9 17442483 (3), 18579430 (1), 18199717 (1), 15496411 (1) (see all 6)
    cancer 0.00 3 15258566 (1), 18554502 (1), 17442483 (1)
    About this table

    1 PharmGKB disease relationship for AKAP12 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
    About this table

    Medical News
    for AKAP12

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    Publications
    for AKAP12

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/44 PubMed articles for AKAP12 gene (see all 44 ):

    Search for AKAP12

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing AKAP12

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 9590 HGNC: 370 AceView: AKAP12 Ensembl:ENSG00000131016 euGenes: HUgn9590
    ECgene: AKAP12 H-InvDB: AKAP12

    Other Databases showing AKAP12

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing AKAP12

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for AKAP12 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for AKAP12

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for AKAP12

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for AKAP12:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for AKAP12-related products

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     Predesigned and custom siRNAs for AKAP12 Antibodies for AKAP12
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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     Antibodies for AKAP12

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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