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Aliases for AKAP12 Gene

Aliases for AKAP12 Gene

  • A Kinase (PRKA) Anchor Protein 12 2 3
  • Src-Suppressed C Kinase Substrate 2 3
  • AKAP 250 3 4
  • AKAP250 3 4
  • Gravin 2 4
  • A Kinase (PRKA) Anchor Protein (Gravin) 12 2
  • Myasthenia Gravis Autoantigen Gravin 3
  • A-Kinase Anchor Protein, 250kDa 3
  • A-Kinase Anchor Protein 250 KDa 4
  • Kinase Scaffold Protein Gravin 3
  • Myasthenia Gravis Autoantigen 4
  • A-Kinase Anchor Protein 12 3
  • AKAP-12 4
  • SSeCKS 3

External Ids for AKAP12 Gene

Previous GeneCards Identifiers for AKAP12 Gene

  • GC06P151122
  • GC06P151456
  • GC06P151592
  • GC06P151653
  • GC06P149123
  • GC06P151561

Summaries for AKAP12 Gene

Entrez Gene Summary for AKAP12 Gene

  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKAP12 Gene

AKAP12 (A Kinase (PRKA) Anchor Protein 12) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein kinase A binding and adenylate cyclase binding.

UniProtKB/Swiss-Prot for AKAP12 Gene

  • Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC)

Gene Wiki entry for AKAP12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP12 Gene

Genomics for AKAP12 Gene

Regulatory Elements for AKAP12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AKAP12 Gene

Start:
151,239,999 bp from pter
End:
151,358,559 bp from pter
Size:
118,561 bases
Orientation:
Plus strand

Genomic View for AKAP12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKAP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP12 Gene

Proteins for AKAP12 Gene

  • Protein details for AKAP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02952-AKA12_HUMAN
    Recommended name:
    A-kinase anchor protein 12
    Protein Accession:
    Q02952
    Secondary Accessions:
    • O00310
    • O00498
    • Q4LE68
    • Q5SZ80
    • Q5TGN1
    • Q68D82
    • Q99970

    Protein attributes for AKAP12 Gene

    Size:
    1782 amino acids
    Molecular mass:
    191482 Da
    Quaternary structure:
    • Binds to dimeric RII-alpha regulatory subunit of PKC
    Miscellaneous:
    • Antibodies against the C-terminal of gravin can be produced by patients with myasthenia gravis (MG)
    SequenceCaution:
    • Sequence=BAE06085.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for AKAP12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKAP12 Gene

Proteomics data for AKAP12 Gene at MOPED

Post-translational modifications for AKAP12 Gene

  • Ubiquitination at Lys177, Lys182, and Lys298
  • Modification sites at PhosphoSitePlus

Other Protein References for AKAP12 Gene

Antibody Products

No data available for DME Specific Peptides for AKAP12 Gene

Domains for AKAP12 Gene

Gene Families for AKAP12 Gene

HGNC:
  • AKAP :A-kinase anchor proteins

Protein Domains for AKAP12 Gene

Suggested Antigen Peptide Sequences for AKAP12 Gene

Graphical View of Domain Structure for InterPro Entry

Q02952

UniProtKB/Swiss-Prot:

AKA12_HUMAN :
  • Q02952
Domain:
  • Polybasic regions located between residues 266 and 557 are involved in binding PKC
  • Contains 3 AKAP domains.
genes like me logo Genes that share domains with AKAP12: view

Function for AKAP12 Gene

Molecular function for AKAP12 Gene

GENATLAS Biochemistry: A kinase (PRKA regulatory subunits PRKC and RIIA) anchor protein 12,expressed in endothelial cells and several adherent cells
UniProtKB/Swiss-Prot Function: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC)
UniProtKB/Swiss-Prot Induction: Activated by lysophosphatidylcholine (lysoPC)

Gene Ontology (GO) - Molecular Function for AKAP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20029029
GO:0008179 adenylate cyclase binding IPI 17081159
GO:0051018 protein kinase A binding IEA --
genes like me logo Genes that share ontologies with AKAP12: view
genes like me logo Genes that share phenotypes with AKAP12: view

Animal Models for AKAP12 Gene

MGI Knock Outs for AKAP12:

Animal Model Products

CRISPR Products

miRNA for AKAP12 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKAP12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AKAP12 Gene

Localization for AKAP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP12 Gene

Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=May be part of the cortical cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP12 Gene COMPARTMENTS Subcellular localization image for AKAP12 gene
Compartment Confidence
cytoskeleton 4
plasma membrane 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for AKAP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA --
GO:0005925 focal adhesion IDA 21423176
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with AKAP12: view

Pathways for AKAP12 Gene

genes like me logo Genes that share pathways with AKAP12: view

Pathways by source for AKAP12 Gene

1 BioSystems pathway for AKAP12 Gene
1 GeneGo (Thomson Reuters) pathway for AKAP12 Gene

Gene Ontology (GO) - Biological Process for AKAP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0007165 signal transduction --
GO:0007186 G-protein coupled receptor signaling pathway TAS 10858453
GO:0010739 positive regulation of protein kinase A signaling IMP 17081159
GO:0030819 positive regulation of cAMP biosynthetic process IMP 17081159
genes like me logo Genes that share ontologies with AKAP12: view

Compounds for AKAP12 Gene

(1) Novoseek inferred chemical compound relationships for AKAP12 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 0 1
genes like me logo Genes that share compounds with AKAP12: view

Transcripts for AKAP12 Gene

Unigene Clusters for AKAP12 Gene

A kinase (PRKA) anchor protein 12:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKAP12

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for AKAP12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP12 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - - -
SP2: - - - -
SP3:
SP4: - - - - - - -
SP5: -
SP6:
SP7:

Relevant External Links for AKAP12 Gene

GeneLoc Exon Structure for
AKAP12
ECgene alternative splicing isoforms for
AKAP12

Expression for AKAP12 Gene

mRNA expression in normal human tissues for AKAP12 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKAP12 Gene

SOURCE GeneReport for Unigene cluster for AKAP12 Gene Hs.371240

mRNA Expression by UniProt/SwissProt for AKAP12 Gene

Q02952-AKA12_HUMAN
Tissue specificity: Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells
genes like me logo Genes that share expressions with AKAP12: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for AKAP12 Gene

Orthologs for AKAP12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAP12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKAP12 35
  • 99.08 (n)
  • 98.62 (a)
AKAP12 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AKAP12 35
  • 73.67 (n)
  • 65.99 (a)
AKAP12 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKAP12 35
  • 76.88 (n)
  • 68.91 (a)
AKAP12 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akap12 35
  • 71.02 (n)
  • 61.03 (a)
Akap12 16
Akap12 36
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AKAP12 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKAP12 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akap12 35
  • 71.37 (n)
  • 62.02 (a)
chicken
(Gallus gallus)
Aves AKAP12 36
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKAP12 36
  • 45 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia gl 35
zebrafish
(Danio rerio)
Actinopterygii akap12a 36
  • 11 (a)
OneToOne
Species with no ortholog for AKAP12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKAP12 Gene

ENSEMBL:
Gene Tree for AKAP12 (if available)
TreeFam:
Gene Tree for AKAP12 (if available)

Paralogs for AKAP12 Gene

Selected SIMAP similar genes for AKAP12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with AKAP12: view

No data available for Paralogs for AKAP12 Gene

Variants for AKAP12 Gene

Sequence variations from dbSNP and Humsavar for AKAP12 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs7515 -- 151,358,463(+) TAGTC(C/G)AAGAC utr-variant-3-prime
rs9206 -- 151,358,063(+) TATCT(A/G)TGTCC utr-variant-3-prime
rs222570 -- 151,336,263(+) atttt(A/G)tctct intron-variant
rs222571 -- 151,336,574(+) acccc(A/G)tctct intron-variant
rs222572 -- 151,337,170(+) AGTTA(C/T)CTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKAP12 Gene

Variant ID Type Subtype PubMed ID
esv2664668 CNV Deletion 23128226
dgv1163e199 CNV Deletion 23128226
nsv521795 CNV Loss 19592680
nsv519279 CNV Loss 19592680
esv2732897 CNV Deletion 23290073
nsv349261 CNV Loss 16902084
esv2410237 CNV Deletion 18987734
esv2732898 CNV Deletion 23290073
nsv5541 CNV Insertion 18451855
nsv518240 CNV Loss 19592680

Relevant External Links for AKAP12 Gene

HapMap Linkage Disequilibrium report
AKAP12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP12 Gene

Disorders for AKAP12 Gene

(2) Novoseek inferred disease relationships for AKAP12 Gene

Disease -log(P) Hits PubMed IDs
cancer 9.64 4
tumors 2.02 8

Relevant External Links for AKAP12

Genetic Association Database (GAD)
AKAP12
Human Genome Epidemiology (HuGE) Navigator
AKAP12
genes like me logo Genes that share disorders with AKAP12: view

No data available for UniProtKB/Swiss-Prot for AKAP12 Gene

Publications for AKAP12 Gene

  1. Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein. (PMID: 9000000) Nauert J.B. … Scott J.D. (Curr. Biol. 1997) 2 3 4
  2. Changes of gene expression by lysophosphatidylcholine in vascular endothelial cells: 12 up-regulated distinct genes including 5 cell growth-related, 3 thrombosis-related, and 4 others. (PMID: 9604001) Sato N. … Miyata T. (J. Biochem. 1998) 3 4
  3. AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity. (PMID: 15258566) Choi M.C. … Bang Y.J. (Oncogene 2004) 3 23
  4. Multiple promoters direct expression of three AKAP12 isoforms with distinct subcellular and tissue distribution profiles. (PMID: 15496411) Streb J.W. … Miano J.M. (J. Biol. Chem. 2004) 4 23
  5. AKAP12alpha, an atypical serum response factor-dependent target gene. (PMID: 15590635) Streb J.W. … Miano J.M. (J. Biol. Chem. 2005) 3 23

Products for AKAP12 Gene

  • antibodies-online proteins for AKAP12
  • antibodies-online antibodies for AKAP12
  • antibodies-online kits for AKAP12

Sources for AKAP12 Gene

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