AKAP12 Gene
protein-coding GIFtS : 62
GCID: GC06 P151561
A kinase (PRKA) anchor protein 12 (Previous name: A kinase (PRKA) anchor protein (gravin) 12 )
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Aliasesfor AKAP12 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases A Kinase (PRKA) Anchor Protein 12 1 2 Kinase Scaffold Protein Gravin2 AKAP2501 2 3 Myasthenia Gravis Autoantigen Gravin2 SSeCKS1 2 Src-Suppressed C Kinase Substrate2 AKAP 2502 3 AKAP-123 A Kinase (PRKA) Anchor Protein (Gravin) 121 Gravin3 A-Kinase Anchor Protein 122 A-Kinase Anchor Protein 250 KDa3 A-Kinase Anchor Protein, 250kDa2 Myasthenia Gravis Autoantigen3
Export aliases for AKAP12 gene to outside databases Previous GC identifers: GC06P151122 GC06P151456 GC06P151592 GC06P151653 GC06P149123
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Summariesfor AKAP12 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for AKAP12 : The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: AKA12_HUMAN, Q02952 Function : Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinaseC (PKC) Gene Wiki entry for AKAP12
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Genomic Viewsfor AKAP12 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_025741.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the AKAP12 gene promoter: GR NF-1 NF-1/L AML1a GR-beta STAT5A HEN1 HFH-1 GR-alpha ATF6 Other transcription factors Search SABiosciences Chromatin IP Primers for AKAP12 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat AKAP12
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6q24-q25 Ensembl cytogenetic band: 6q25.1 HGNC cytogenetic band: 6q24-q25 AKAP12 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P151561: view genomic region
(about GC identifiers )
Start:
151,561,134 bp from pter
End:
151,679,694 bp from pter
Size:
118,561 bases
Orientation:
plus strand
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Proteinsfor AKAP12 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: AKA12_HUMAN, Q02952 (See
protein sequence )Recommended Name: A-kinase anchor protein 12 Size : 1782 amino acids; 191482 Da
Subunit : Binds to dimeric RII-alpha regulatory subunit of PKC
Subcellular location : Cytoplasm, cell cortex (Probable). Cytoplasm, cytoskeleton (Probable). Note=May be part of thecortical cytoskeleton
Miscellaneous : Antibodies against the C-terminal of gravin can be produced by patients with myasthenia gravis (MG)
Sequence caution : Sequence=BAE06085.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions : O00310 O00498 Q4LE68 Q5SZ80 Q5TGN1 Q68D82 Q99970Alternative splicing : 3 isoforms : Q02952-1 Q02952-2 Q02952-3 Explore the universe of human proteins at neXtProt for AKAP12: NX_Q02952 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q02952 AKAP12 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_005091.2 NP_653080.1 ENSEMBL proteins: ENSP00000253332 ENSP00000346702 ENSP00000384537 ENSP00000352794 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
AKAP12 for ontologies About GeneDecksing AKAP12 Antibody Products: Assay Products for AKAP12:
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Protein
Domains / Familiesfor AKAP12 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
AKAP12 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q02952 ProtoNet protein and cluster: Q02952
1 Blocks protein family : IPB001573 Protein kinase A anchoring domain UniProtKB/Swiss-Prot: AKA12_HUMAN, Q02952 Domain : Polybasic regions located between residues 266 and 557 are involved in binding PKCSimilarity : Contains 3 AKAP domains
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Functionfor AKAP12 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: AKA12_HUMAN, Q02952 Function : Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinaseC (PKC) Induction : Activated by lysophosphatidylcholine (lysoPC)
Genatlas biochemistry entry for AKAP12 : A kinase (PRKA regulatory subunits PRKC and RIIA) anchor protein 12,expressed in endothelial cells and several adherent cells Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AKAP12 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AKAP12 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): AKAP12 (NM_144497 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AKAP12 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AKAP12
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP12
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
AKAP12 for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for AKAP12 :Animal Models: Mouse knock-out Akap12 tm1Ihg for AKAP12 11 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Akap12) :
AKAP12 for phenotypes About GeneDecksing
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Pathways & Interactionsfor AKAP12 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Activation of cAMP-Dependent PKA 2 G Protein Signaling Pathways
Pathway sources See GeneCards unified pathways Show all pathways 1 EMD Millipore Pathway for AKAP12 4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AKAP12 1 GeneGo (Thomson Reuters) Pathway for AKAP12 1 BioSystems Pathway for AKAP12
AKAP12 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AKAP12 STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)5/10 Interacting proteins for AKAP12 (Q02952 1 , 2 , 3 ENSP00000253332 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 10 )Interactant Interaction Details GeneCard External ID(s) FHL1 Q13642 2 , 3 , ENSP00000359724 4 MINT-8255365 I2D:
score=3 STRING: ENSP00000359724 PRKAR2A P13861 2 , 3 , ENSP00000265563 4 MINT-2411858 I2D:
score=3 STRING: ENSP00000265563 PDE4D Q08499 2 , 3 , ENSP00000384806 4 MINT-2411838 I2D:
score=1 STRING: ENSP00000384806 EGFR P00533 1 , 3 , ENSP00000275493 4 EBI-2680946,EBI-297353 I2D:
score=2 STRING: ENSP00000275493 ADRB2 P07550 3 , ENSP00000305372 4 I2D:
score=2 STRING: ENSP00000305372
About this table Gene Ontology (GO): 5 biological process terms (GO ID links to tree view) : About this table
AKAP12 for ontologies About GeneDecksing
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Drugs & Compoundsfor AKAP12 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
AKAP12 for compounds About GeneDecksing Browse Tocris compounds for AKAP12 1 Novoseek chemical compound relationship for AKAP12 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine
0
1
14715081 (1)
Search CenterWatch for drugs/clinical trials and news about AKAP12 / AKA12
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Transcriptsfor AKAP12 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for AKAP12 gene (2 alternative transcripts): NM_005100.3 NM_144497.2 Unigene Cluster for AKAP12:
A kinase (PRKA) anchor protein 12 Hs.371240 [show with all ESTs ] Unigene Representative Sequence: NM_005100 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000253332 ENST00000354675 ENST00000490177 ENST00000402676 (uc011eep.2 uc003qoe.3 uc003qof.3 uc010kim.3 uc003qog.3 )ENST00000359755 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AKAP12 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AKAP12 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): AKAP12 (NM_144497 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AKAP12 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AKAP12
Additional cDNA sequence: AB003476.1 AB210003.1 AF001504.1 AF086250.1 AK024598.1 AK126161.1 AK307578.1 AK307673.1 AK307739.1 BC000188.1 BC015830.1 BC022814.1 BC033829.1 BC047728.1 BC070151.1 BC117679.1 BC117680.1 CR749527.1 CR936604.1 M96322.1 U81607.1
14 DOTS entries : DT.95170629 DT.100823862
DT.97843539 DT.100823860 DT.87016407 DT.75106825 DT.100031427 DT.75138132 DT.100680885 DT.91650893 DT.97800929 DT.121362334 DT.40132830 DT.95170641 24/362 AceView cDNA sequences (see all 362 ):
F03530 BU149157 CF780760 BF114967 BQ221404 BI494934 BC047728 AL041580 AI078016 AK126161 AL041405 F03015 AL040086 BF511548 BM679663 NM_005100 BQ717711 BX642788 AI656759 CA396125 BM461663 BE378422 BQ432119 AL119021 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AKAP12 (see all 7 ) About this scheme ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b SP1 :   -           -   -   -   -             SP2 :             -   -   -   -             SP3 :                               SP4 :             -   -   -   -   -   -   -       SP5 :                   -            
ECgene alternative splicing isoforms for AKAP12
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Expression for AKAP12 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section AKAP12 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGTTGCCTCT
About this image AKAP12 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 2 LifeMap Cells Name Category Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass Posterior foregut-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See AKAP12 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for AKAP12 SOURCE GeneReport for Unigene cluster: Hs.371240 UniProtKB/Swiss-Prot: AKA12_HUMAN, Q02952 Tissue specificity : Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets,leukocytes, monocytic cell lines or peripherical blood cells SABiosciences Custom PCR Arrays for AKAP12 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for AKAP12Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat AKAP12 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat AKAP12 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat AKAP12 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP12
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Orthologsfor AKAP12 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for AKAP12 gene from 8/21 species (see all 21 ) About this table
ENSEMBL Gene Tree for AKAP12 (if available)TreeFam Gene Tree for AKAP12 (if available)
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Paralogsfor AKAP12 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for AKAP12 gene MAP1B 2 MAP1S 2 MAP1A 2 1 SIMAP similar gene for AKAP12 using alignment to 3 protein entries: AKA12_HUMAN (see all proteins ):DKFZp686M0430
AKAP12 for paralogs About GeneDecksing
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Genomic Variantsfor AKAP12 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for AKAP12 (151561134 - 151679694 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for AKAP12 1 CNV : 51822 1 Indel : 12867
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing AKAP12
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Disorders
/ Diseasesfor AKAP12 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
AKAP12 for disorders About GeneDecksing
OMIM gene information: 604698
OMIM disorders : --20/25 diseases for AKAP12 (see all 25 ): About MalaCards myasthenia gravis myasthenia osteosarcoma pancreatic ductal adenocarcinoma chronic myeloid leukemia myeloid leukemia myeloid malignancy kidney disease fibrosarcoma thrombosis colorectal cancer leukemia lung cancer adenocarcinoma prostate cancer pancreatitis esophagitis cholesterol hypoxia retinitis 2 Novoseek disease relationships for AKAP12 gene About this table
Human Genome Epidemiology (HuGE) Navigator: AKAP12 (3 documents) Export disorders for AKAP12 gene to outside databases
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Publicationsfor AKAP12 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for AKAP12 gene, integrated from 9 sources (see all 71 ): (articles sorted by number of sources associating them with AKAP12) Utopia : connect your pdf to the dynamic world of online information
Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein. (PubMed id 9000000) 1 , 2 , 3 Nauert J.B.... Scott J.D. (1997) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 Olsen J.V....Mann M. (2006) Changes of gene expression by lysophosphatidylcholine in vascular endothelial cells: 12 up-regulated distinct genes including 5 cell growth-related, 3 thrombosis-related, and 4 others. (PubMed id 9604001) 1 , 2 Sato N.... Miyata T. (1998) Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera. (PubMed id 1522245) 1 , 2 Gordon T.... Ginsberg M.H. (1992) Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression. (PubMed id 18199717) 1 , 9 Jin Z....Meltzer S.J. (2008) Multiple promoters direct expression of three AKAP12 isoforms with distinct subcellular and tissue distribution profiles. (PubMed id 15496411) 2 , 9 Streb J.W.... Miano J.M. (2004) G-protein-coupled receptor-associated A-kinase anchoring proteins AKAP5 and AKAP12: differential trafficking and distribution. (PubMed id 18950703) 1 , 9 Chen M.H. and Malbon C.C. (2009) A-kinase anchoring protein 12 regulates the completion of cytokinesis. (PubMed id 18554502) 1 , 9 Choi M.C....Bang Y.J. (2008) AKAP12 in astrocytes induces barrier functions in human endothelial cells through protein kinase Czeta. (PubMed id 18397319) 1 , 9 Choi Y.K. and Kim K.W. (2008) AKAP12 regulates human blood-retinal barrier formation by downregulation of hypoxia-inducible factor-1alpha. (PubMed id 17442832) 1 , 9 Choi Y.K....Kim K.W. (2007)
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External Searches for AKAP12 gene
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Specialized Databases showing AKAP12 gene (According to PharmGKB ,
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About This Section Patent Information for AKAP12 gene: Search GeneIP for patents involving AKAP12 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor AKAP12 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for AKAP12 OriGene shRNA RFP for AKAP12 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for AKAP12 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for AKAP12 OriGene Protein Over-expression Lysate for AKAP12 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for AKAP12 OriGene 3'-UTR Clone for AKAP12 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AKAP12 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AKAP12 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for AKAP12 OriGene Custom Protein Services for AKAP12 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AKAP12 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing AKAP12 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat AKAP12 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat AKAP12 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat AKAP12 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat AKAP12
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AKAP12 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP12
ThermoFisher Antibody for AKAP12
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AKAP12
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