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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AKAP12 Gene

protein-coding GIFtS: 62
GCID: GC06P151561

A kinase (PRKA) anchor protein 12

(Previous name: A kinase (PRKA) anchor protein (gravin) 12 )

Explore 25 diseases affiliated with
AKAP12 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
A Kinase (PRKA) Anchor Protein 12¹ ²		Kinase Scaffold Protein Gravin²
AKAP250¹ ² ³		Myasthenia Gravis Autoantigen Gravin²
SSeCKS¹ ²		Src-Suppressed C Kinase Substrate²
AKAP 250² ³		AKAP-12³
A Kinase (PRKA) Anchor Protein (Gravin) 12¹		Gravin³
A-Kinase Anchor Protein 12²		A-Kinase Anchor Protein 250 KDa³
A-Kinase Anchor Protein, 250kDa²		Myasthenia Gravis Autoantigen³

External Ids:	HGNC: 370¹	Entrez Gene: 9590²	Ensembl: ENSG00000131016⁷	OMIM: 604698⁵	UniProtKB: Q02952³

Export aliases for AKAP12 gene to outside databases

Previous GC identifers: GC06P151122 GC06P151456 GC06P151592 GC06P151653 GC06P149123

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AKAP12:

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of

binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within

the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells,

cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves

as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein

is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis.

Alternative splicing of this gene results in two transcript variants encoding different isoforms. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: AKA12_HUMAN, Q02952

Function: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase

C (PKC)

Gene Wiki entry for AKAP12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AKAP12 gene promoter:
GR NF-1 NF-1/L AML1a GR-beta STAT5A HEN1 HFH-1 GR-alpha ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): AKAP12 promoter sequence

Search SABiosciences Chromatin IP Primers for AKAP12

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKAP12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24-q25 Ensembl cytogenetic band: 6q25.1 HGNC cytogenetic band: 6q24-q25

AKAP12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKAP12 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P151561: view genomic region (about GC identifiers)

Start:	151,561,134 bp from pter	End:	151,679,694 bp from pter
Size:	118,561 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AKA12_HUMAN, Q02952 (See protein sequence)

Recommended Name: A-kinase anchor protein 12

Size: 1782 amino acids; 191482 Da

Subunit: Binds to dimeric RII-alpha regulatory subunit of PKC

Subcellular location: Cytoplasm, cell cortex (Probable). Cytoplasm, cytoskeleton (Probable). Note=May be part of the

cortical cytoskeleton

Miscellaneous: Antibodies against the C-terminal of gravin can be produced by patients with myasthenia gravis (MG)

Sequence caution: Sequence=BAE06085.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: O00310 O00498 Q4LE68 Q5SZ80 Q5TGN1 Q68D82 Q99970

Alternative splicing: 3 isoforms: Q02952-1 Q02952-2 Q02952-3

Explore the universe of human proteins at neXtProt for AKAP12: NX_Q02952

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q02952

AKAP12 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_005091.2 NP_653080.1

ENSEMBL proteins:

ENSP00000253332 ENSP00000346702 ENSP00000384537 ENSP00000352794

Human Recombinant Protein Products:

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	Novus Biologicals AKAP12 Protein Novus Biologicals AKAP12 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for AKAP12

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005856	cytoskeleton	IEA	--
GO:0005886	plasma membrane	IDA	--
GO:0005938	cell cortex	IEA	--

AKAP12 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for AKAP12

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AKAP12 for domains About GeneDecksing

2 InterPro domains/families:

IPR018459 RII_binding_1

IPR001573 Pkinase-A_anch_WSK-motif

Graphical View of Domain Structure for InterPro Entry Q02952

ProtoNet protein and cluster: Q02952

1 Blocks protein family: IPB001573 Protein kinase A anchoring domain

UniProtKB/Swiss-Prot: AKA12_HUMAN, Q02952

Domain: Polybasic regions located between residues 266 and 557 are involved in binding PKC

Similarity: Contains 3 AKAP domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AKA12_HUMAN, Q02952

Function: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase

C (PKC)

Induction: Activated by lysophosphatidylcholine (lysoPC)

Genatlas biochemistry entry for AKAP12:

A kinase (PRKA regulatory subunits PRKC and RIIA) anchor protein 12,expressed in endothelial cells and several adherent

cells

miRNA Products:		miRTarBase miRNAs that target AKAP12: hsa-mir-186 (MIRT005871), hsa-mir-183 (MIRT005870)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKAP12
		8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate AKAP12 (see all 61):
		hsa-miR-4291 hsa-miR-300 hsa-miR-15a hsa-let-7a-2* hsa-miR-219-5p hsa-miR-29b-1* hsa-miR-3916 hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: AKAP12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKAP12 (see all 7) OriGene shRNA RFP: AKAP12 OriGene siRNA: AKAP12
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for AKAP12

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		Search LifeMap BioReagents cell lines for AKAP12

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP12

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0008179	adenylate cyclase binding	IPI	17081159
GO:0051018	protein kinase A binding	TAS	10858453

AKAP12 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for AKAP12:

Cell division defect

Increased G2M DNA content

Animal Models:
Mouse knock-out Akap12^tm1Ihg for AKAP12
11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Akap12):

behavior/neurological	cardiovascular system	endocrine/exocrine gland	hematopoietic system	immune system
liver/biliary system	mortality/aging	nervous system	normal	reproductive system
respiratory system

AKAP12 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

G Protein Signaling Pathways

	G Protein Signaling Pathways	1.00			Signal transduction_PKA signaling	0.23
	Signal transduction PKA signaling	0.23

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for AKAP12

Signal transduction PKA signaling

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AKAP12

	Activation of PKA through GPCR
	PKA Signaling
	cAMP Pathway
	Activation of cAMP-Dependent PKA

1 GeneGo (Thomson Reuters) Pathway for AKAP12

Signal transduction PKA signaling

1 BioSystems Pathway for AKAP12

G Protein Signaling Pathways

AKAP12 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for AKAP12

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/10 Interacting proteins for AKAP12 (Q02952^{1, 2, 3} ENSP00000253332⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FHL1	Q13642²^,³, ENSP00000359724⁴	MINT-8255365 I2D: score=3 STRING: ENSP00000359724
PRKAR2A	P13861²^,³, ENSP00000265563⁴	MINT-2411858 I2D: score=3 STRING: ENSP00000265563
PDE4D	Q08499²^,³, ENSP00000384806⁴	MINT-2411838 I2D: score=1 STRING: ENSP00000384806
EGFR	P00533¹^,³, ENSP00000275493⁴	EBI-2680946,EBI-297353 I2D: score=2 STRING: ENSP00000275493
ADRB2	P07550³, ENSP00000305372⁴	I2D: score=2 STRING: ENSP00000305372

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006605	protein targeting	IEA	--
GO:0007165	signal transduction	--	--
GO:0007186	G-protein coupled receptor signaling pathway	TAS	10858453
GO:0010739	positive regulation of protein kinase A signaling cascade	IMP	17081159
GO:0030819	positive regulation of cAMP biosynthetic process	IMP	17081159

AKAP12 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

AKAP12 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AKAP12
1 Novoseek chemical compound relationship for AKAP12 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	0	1	14715081 (1)

Search CenterWatch for drugs/clinical trials and news about AKAP12 / AKA12

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AKAP12 gene (2 alternative transcripts):

NM_005100.3 NM_144497.2

Unigene Cluster for AKAP12:

A kinase (PRKA) anchor protein 12

Hs.371240 [show with all ESTs]

Unigene Representative Sequence: NM_005100

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000253332 ENST00000354675 ENST00000490177 ENST00000402676(uc011eep.2 uc003qoe.3 uc003qof.3 uc010kim.3 uc003qog.3)

ENST00000359755

miRNA Products:		OriGene 3'-UTR Clone (see all 2): AKAP12 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKAP12
		8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate AKAP12 (see all 61):
		hsa-miR-4291 hsa-miR-300 hsa-miR-15a hsa-let-7a-2* hsa-miR-219-5p hsa-miR-29b-1* hsa-miR-3916 hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: AKAP12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKAP12 (see all 7) OriGene shRNA RFP: AKAP12 OriGene siRNA: AKAP12
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKAP12

Additional cDNA sequence:

AB003476.1 AB210003.1 AF001504.1 AF086250.1 AK024598.1 AK126161.1 AK307578.1 AK307673.1

AK307739.1 BC000188.1 BC015830.1 BC022814.1 BC033829.1 BC047728.1 BC070151.1 BC117679.1

BC117680.1 CR749527.1 CR936604.1 M96322.1 U81607.1

14 DOTS entries:

DT.95170629 DT.100823862 DT.97843539 DT.100823860 DT.87016407 DT.75106825 DT.100031427 DT.75138132

DT.100680885 DT.91650893 DT.97800929 DT.121362334 DT.40132830 DT.95170641

24/362 AceView cDNA sequences (see all 362):

F03530 BU149157 CF780760 BF114967 BQ221404 BI494934 BC047728 AL041580

AI078016 AK126161 AL041405 F03015 AL040086 BF511548 BM679663 NM_005100

BQ717711 BX642788 AI656759 CA396125 BM461663 BE378422 BQ432119 AL119021

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AKAP12 (see all 7) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b
SP1:			-										-		-		-		-
SP2:													-		-		-		-
SP3:
SP4:													-		-		-		-		-		-		-
SP5:																			-

ECgene alternative splicing isoforms for AKAP12

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AKAP12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTTGCCTCT

About this image

AKAP12 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Line H7 (WA07) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See AKAP12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AKAP12

SOURCE GeneReport for Unigene cluster: Hs.371240

UniProtKB/Swiss-Prot: AKA12_HUMAN, Q02952

Tissue specificity: Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets,

leukocytes, monocytic cell lines or peripherical blood cells

SABiosciences Custom PCR Arrays for AKAP12

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKAP12

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for AKAP12 gene from 8/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	AKAP12⁶	Uncharacterized protein	47(a)	1 ↔ 1	3(50734495-50737737)
lizard (Anolis carolinensis)	Reptilia	AKAP12⁶	--	44(a)	1 ↔ 1	GL343259.1(1111045-1116690)
African clawed frog (Xenopus laevis)	Amphibia	gl²	gravin-like	75.07(n)		AF308810.1
zebrafish (Danio rerio)	Actinopterygii	akap12b¹	A kinase (PRKA) anchor protein (gravin) 12b	49.14(n) 38.91(a)		567365 NM_001098184.1 NP_001091654.1
fruit fly (Drosophila melanogaster)	Insecta	CG1910⁶ CG14692⁶ (see all 3)	--	7(a) 5(a) (see all 3)	1 ↔ many 1 ↔ many (see all 3)	3R(27571766-27576745) 3R(6619849-6629631)
worm (Caenorhabditis elegans)	Secernentea	T23E7.2⁶	Protein T23E7.2, isoform e	6(a)	1 ↔ 1	X(17670953-17680714)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G40450⁶	uncharacterized protein	4(a)	1 ↔ 1	5(16184650-16195651)
rice (Oryza sativa)	Liliopsida	--	expressed protein	4(a)	possible ortholog	2(1617326-1630169)

ENSEMBL Gene Tree for AKAP12 (if available)
TreeFam Gene Tree for AKAP12 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AKAP12 gene

MAP1B² MAP1S² MAP1A²

1 SIMAP similar gene for AKAP12 using alignment to 3 protein entries: AKA12_HUMAN (see all proteins):

DKFZp686M0430

AKAP12 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28489215^1,2	C	--	149241091(+)	`TATAAT/ATTTTT`	1	--	ut3¹		1		WA	2
rs112332754^1,2	F,	--	151559168(+)	`TGGCAC/TGATCT`	1	--	us2k¹		2		CSA	4
rs188730437^1,2		--	151559206(+)	`GTTCAA/GGCAGT`	1	--	us2k¹		0	--	--	--	--
rs191599069^1,2		--	151559272(+)	`GGCTAA/CTTTTT`	1	--	us2k¹		0	--	--	--	--
rs113146383^1,2	C,	--	151559282(+)	`TGTACT/-TTTAG`	1	--	us2k¹		1		CSA	2
rs139607585^1,2		--	151559294(+)	`AGAGAC/TGGGGT`	1	--	us2k¹		0	--	--	--	--
rs183604045^1,2		--	151559466(+)	`GCCACA/GTTTCA`	1	--	us2k¹		0	--	--	--	--
rs188708673^1,2		--	151559626(+)	`TCTCCA/GGGCCT`	1	--	us2k¹		0	--	--	--	--
rs149739454^1,2		--	151559682(+)	`ATCCCA/GTGGGG`	1	--	us2k¹		0	--	--	--	--
rs6906905^1,2	C,F,A,H,	--	151559709(+)	`TATGTA/GAAGTG`	1	--	us2k¹		16		NS EA NA CSA WA	1736

HapMap Linkage Disequilibrium report for AKAP12 (151561134 - 151679694 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for AKAP12
1 CNV: 51822
1 Indel: 12867

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AKAP12 for disorders           About GeneDecksing

OMIM gene information: 604698    OMIM disorders: --

20/25 diseases for AKAP12 (see all 25):    About MalaCards

myasthenia gravis myasthenia osteosarcoma pancreatic ductal adenocarcinoma

chronic myeloid leukemia myeloid leukemia myeloid malignancy kidney disease

fibrosarcoma thrombosis colorectal cancer leukemia

lung cancer adenocarcinoma prostate cancer pancreatitis

esophagitis cholesterol hypoxia retinitis

2 Novoseek disease relationships for AKAP12 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	9.64	4	15258566 (1), 18554502 (1), 17442483 (1), 20227403 (1)
tumors	2.02	9	17442483 (3), 18579430 (1), 18199717 (1), 15496411 (1) (see all 6)

Human Genome Epidemiology (HuGE) Navigator: AKAP12 (3 documents)

Export disorders for AKAP12 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for AKAP12 gene, integrated from 9 sources (see all 71):
(articles sorted by number of sources associating them with AKAP12)

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world of online information

Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein. (PubMed id 9000000)^{1, 2, 3} Nauert J.B.... Scott J.D. (1997)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Changes of gene expression by lysophosphatidylcholine in vascular endothelial cells: 12 up-regulated distinct genes including 5 cell growth-related, 3 thrombosis-related, and 4 others. (PubMed id 9604001)^{1, 2} Sato N.... Miyata T. (1998)
Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera. (PubMed id 1522245)^{1, 2} Gordon T.... Ginsberg M.H. (1992)
Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression. (PubMed id 18199717)^{1, 9} Jin Z....Meltzer S.J. (2008)
Multiple promoters direct expression of three AKAP12 isoforms with distinct subcellular and tissue distribution profiles. (PubMed id 15496411)^{2, 9} Streb J.W.... Miano J.M. (2004)
G-protein-coupled receptor-associated A-kinase anchoring proteins AKAP5 and AKAP12: differential trafficking and distribution. (PubMed id 18950703)^{1, 9} Chen M.H. and Malbon C.C. (2009)
A-kinase anchoring protein 12 regulates the completion of cytokinesis. (PubMed id 18554502)^{1, 9} Choi M.C....Bang Y.J. (2008)
AKAP12 in astrocytes induces barrier functions in human endothelial cells through protein kinase Czeta. (PubMed id 18397319)^{1, 9} Choi Y.K. and Kim K.W. (2008)
AKAP12 regulates human blood-retinal barrier formation by downregulation of hypoxia-inducible factor-1alpha. (PubMed id 17442832)^{1, 9} Choi Y.K....Kim K.W. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9590	HGNC: 370	AceView: AKAP12	Ensembl:ENSG00000131016	euGenes: HUgn9590
ECgene: AKAP12	H-InvDB: AKAP12

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for AKAP12	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for AKAP12	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for AKAP12 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for AKAP12 gene:
Search GeneIP for patents involving AKAP12

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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A kinase (PRKA) anchor protein 12

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AKAP12 Gene

A kinase (PRKA) anchor protein 12

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