Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AKAP11 Gene

protein-coding   GIFtS: 55
GCID: GC13P042846

A kinase (PRKA) anchor protein 11

  Search for AKAP11
in our new
 Human Malady Compendium 
Biological research products
for AKAP11
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
A Kinase (PRKA) Anchor Protein 111 2     FLJ113041
AKAP2201 2 3     A Kinase Anchor Protein 220 KDa2
PRKA111 2 3     A-Kinase Anchor Protein 112
PPP1R441 2     A-Kinase Anchoring Protein, 220kDa2
KIAA06291 3     Protein Kinase A Anchoring Protein 112
Protein Kinase A-Anchoring Protein 112 3     Protein Phosphatase 1, Regulatory Subunit 442
AKAP-112 3     AKAP 2203
A-Kinase Anchor Protein 220 KDa2 3     HAKAP2201
DKFZp781I121611     

External Ids:    HGNC: 3691   Entrez Gene: 112152   Ensembl: ENSG000000235167   OMIM: 6046965   UniProtKB: Q9UKA43   

Export aliases for AKAP11 gene to outside databases

Previous GC identifers: GC13P040846 GC13P036832 GC13P041782 GC13P040644 GC13P041744 GC13P023649


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AKAP11:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of
binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within
the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout
spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in
cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm
function. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AKA11_HUMAN, Q9UKA4
Function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them

Gene Wiki entry for AKAP11


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AKAP11 gene promoter:
         Max1   RP58   NF-1/L   NF-1   IRF-1   Nkx2-5   HEN1   MRF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAKAP11 promoter sequence
   Search SABiosciences Chromatin IP Primers for AKAP11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKAP11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.11   Ensembl cytogenetic band:  13q14.11   HGNC cytogenetic band: 13q

AKAP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKAP11 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P042846:  view genomic region     (about GC identifiers)

Start:
42,846,289 bp from pter      End:
42,897,402 bp from pter
Size:
51,114 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AKA11_HUMAN, Q9UKA4 (See protein sequence)
Recommended Name: A-kinase anchor protein 11  
Size: 1901 amino acids; 210512 Da
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Note=Cytoplasmic in premeiotic pachytene
spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was
found in elongating spermatocytes and mature sperm
Sequence caution: Sequence=BAA92117.1; Type=Erroneous initiation;
Secondary accessions: O75124 Q9NUK7

Explore the universe of human proteins at neXtProt for AKAP11: NX_Q9UKA4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UKA4

  • AKAP11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057332.1  
    ENSEMBL proteins: 
     ENSP00000025301  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for AKAP11 
    GenScript Custom Purified and Recombinant Proteins Services for AKAP11
    Novus Biologicals AKAP11 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for AKAP11

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005815microtubule organizing center IEA--
    GO:0005886plasma membrane IDA--
    GO:0043234protein complex ----


    AKAP11 for ontologies           About GeneDecksing



    AKAP11 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for AKAP11 
    GenScript Custom Superior Antibodies Services for AKAP11
    Novus Biologicals AKAP11 Antibodies
    Search for Antibodies for AKAP11 at Abcam  
    Uscn Antibodies for AKAP11
    Search ThermoFisher Antibodies for AKAP11

    Assay Products for AKAP11: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AKAP11
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for AKAP11


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    AKAP11 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008382 SPHK1-interactor_AKAP_110

    Graphical View of Domain Structure for InterPro Entry Q9UKA4

    ProtoNet protein and cluster: Q9UKA4

    1 Blocks protein family: IPB008382 A-kinase anchor 110 kDa

    UniProtKB/Swiss-Prot: AKA11_HUMAN, Q9UKA4
    Domain: RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein
    interactions with a complementary surface on the R-subunit dimer
    Similarity: Belongs to the AKAP110 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: AKA11_HUMAN, Q9UKA4
    Function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them

         Genatlas biochemistry entry for AKAP11:
    A kinase (PRKA,regulating subunit RIIA) anchor protein 11,expressed in brain,related to rat A kinase anchoring protein
    AKAP220

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: AKAP11
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKAP11
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate AKAP11 (see all 57):
    hsa-miR-323-3p hsa-miR-142-5p hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-503 hsa-miR-548l hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidAKAP11 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKAP11 (see all 4)
    OriGene shRNA RFP: AKAP11
    OriGene siRNA: AKAP11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKAP11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AKAP11

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKAP11 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKAP11
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: AKAP11 (NM_016248)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKAP11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKAP11 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AKAP11
    Search LifeMap BioReagents cell lines for AKAP11

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP11

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008157protein phosphatase 1 binding TAS10209101
    GO:0032947protein complex scaffold ----
    GO:0034236protein kinase A catalytic subunit binding ----
    GO:0034237protein kinase A regulatory subunit binding ----
    GO:0051018protein kinase A binding TAS10209101


    AKAP11 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for AKAP11:
     Decreased focal adhesion (FA)   Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA1.00
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2G Protein Signaling Pathways
    G Protein Signaling Pathways1.00
    Signal transduction_PKA signaling0.23
    Signal transduction PKA signaling0.23

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for AKAP11
        Signal transduction PKA signaling

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AKAP11
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 GeneGo (Thomson Reuters) Pathway for AKAP11
        Signal transduction PKA signaling

    1 BioSystems Pathway for AKAP11 
        G Protein Signaling Pathways



    AKAP11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AKAP11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/16 Interacting proteins for AKAP11 (Q9UKA43 ENSP000000253014) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498413, ENSP000003248064I2D: score=3 STRING: ENSP00000324806
    PRKAR1AP106443, ENSP000003514104I2D: score=3 STRING: ENSP00000351410
    PRKAR2AP138613, ENSP000002655634I2D: score=3 STRING: ENSP00000265563
    PRKAR2BP313233, ENSP000002657174I2D: score=3 STRING: ENSP00000265717
    PPP1CAP621363, ENSP000003260314I2D: score=2 STRING: ENSP00000326031
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007243intracellular protein kinase cascade TAS10209101
    GO:0010738regulation of protein kinase A signaling cascade ----


    AKAP11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AKAP11
    Search CenterWatch for drugs/clinical trials and news about AKAP11 / AKA11 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AKAP11 gene (2 alternative transcripts): 
    NM_016248.3  NM_144490.1  

    Unigene Cluster for AKAP11:

    A kinase (PRKA) anchor protein 11
    Hs.105105  [show with all ESTs]
    Unigene Representative Sequence: NM_016248
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000025301(uc001uys.2)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: AKAP11
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AKAP11
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate AKAP11 (see all 57):
    hsa-miR-323-3p hsa-miR-142-5p hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-503 hsa-miR-548l hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidAKAP11 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKAP11 (see all 4)
    OriGene shRNA RFP: AKAP11
    OriGene siRNA: AKAP11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKAP11
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKAP11 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKAP11
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: AKAP11 (NM_016248)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKAP11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKAP11 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKAP11
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AKAP11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKAP11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKAP11

    Additional cDNA sequence: 

    AB014529.2 AF176555.1 AK002166.1 AK074384.1 CR627087.1 

    8 DOTS entries:

    DT.114752  DT.100023768  DT.100704976  DT.100769091  DT.120776864  DT.120776877  DT.95223295  DT.120776881 

    24/156 AceView cDNA sequences (see all 156):

    AA463313 BQ719874 AI357298 CR627087 AA862480 AK002166 BX283776 NM_144490 
    BX483248 AA837616 BU620731 CN479538 AA112737 BI335861 BU167169 F37180 
    AI039073 AI285046 BM460367 CB266408 AL045871 AI573202 AI370183 BP368267 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for AKAP11 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c
    SP1:              -     -                                                                                                                                 
    SP2:                    -                                                                                                                                 
    SP3:                    -     -                                                                                                                           
    SP4:                                                                                                                    -                                 
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for AKAP11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AKAP11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGAATATAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See AKAP11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AKAP11

    SOURCE GeneReport for Unigene cluster: Hs.105105

    UniProtKB/Swiss-Prot: AKA11_HUMAN, Q9UKA4
    Tissue specificity: Expressed in heart, brain, lung, liver, kidney, testis and ovary. Weakly expressed in skeletal
    muscle, pancreas and spleen

        SABiosciences Custom PCR Arrays for AKAP11
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKAP11
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AKAP11
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKAP11
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKAP11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AKAP11 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akap111 , 5 A kinase (PRKA) anchor protein 111, 5 81.85(n)1
    75.07(a)1
      14 (41.46 cM)5
    2191811  NM_001164503.11  NP_001157975.11 
     784922465 
    chicken
    (Gallus gallus)
    Aves AKAP111 A kinase (PRKA) anchor protein 11 65.71(n)
    55.17(a)
      418835  XM_417031.3  XP_417031.3 
    lizard
    (Anolis carolinensis)
    Reptilia AKAP116
    --
    49(a)
    1 ↔ 1
    3(70210795-70234734)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.302202 Xenopus laevis transcribed sequence with weak similarity more 80.26(n)    48025371 
    zebrafish
    (Danio rerio)
    Actinopterygii akap111 A kinase (PRKA) anchor protein 11 54.13(n)
    43.45(a)
      558595  XM_681824.5  XP_686916.5 


    ENSEMBL Gene Tree for AKAP11 (if available)
    TreeFam Gene Tree for AKAP11 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AKAP11 gene
    SPHKAP2  
    1 SIMAP similar gene for AKAP11 using alignment to 1 protein entry:     AKA11_HUMAN:
    DKFZp781I12161

    AKAP11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/952 NCBI SNPs in AKAP11 are shown (see all 952    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs95669531,2
    --42844323(+) TTTTTA/TTAAAA 1 -- us2k1 trp30--------
    rs2383531,2
    C,A,--42844324(-) TTTTTT/AAAAAA 1 -- us2k1 trp32Minor allele frequency- A:0.00NA 4
    rs1148234911,2
    --42844328(+) TTAAAA/TAAAAG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1409631311,2
    --42844380(+) CCTTAC/TATTGC 1 -- us2k10--------
    rs598008191,2
    F,--42844385(+) TATTGC/TGTTTA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1501882231,2
    --42844491(+) AGCACC/TGCCAT 1 -- us2k10--------
    rs1895454361,2
    --42844492(+) GCACCA/GCCATT 1 -- us2k10--------
    rs788776661,2
    --42844645(+) AAATAT/CGCCTC 1 -- us2k12Minor allele frequency- C:0.04CSA EA 121
    rs95256011,2
    C,F,--42844718(+) AGTCTA/GCAATA 1 -- us2k17Minor allele frequency- G:0.11NA WA CSA EA 366
    rs1825732311,2
    --42844947(+) ATCCTC/TACTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AKAP11 (42846289 - 42897402 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for AKAP11: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKAP11
    DNA2.0 Custom Variant and Variant Library Synthesis for AKAP11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    AKAP11 for disorders           About MalaCards

    AKAP11 for disorders           About GeneDecksing

    OMIM gene information: 604696    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: AKAP11 (2 documents)

    Export disorders for AKAP11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AKAP11 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with AKAP11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
    2. Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis. (PubMed id 10864471)1, 2, 9 Reinton N.... Tasken K. (2000)
    3. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    6. Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes. (PubMed id 8621616)1, 3 Lester L.B....Scott J.D. (1996)
    7. Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation. (PubMed id 11152471)1, 9 Schillace R.V....Scott J.D. (2001)
    8. Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes. (PubMed id 11823486)1, 9 Schillace R.V.... Carr D.W. (2002)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11215 HGNC: 369 AceView: AKAP11 Ensembl:ENSG00000023516 euGenes: HUgn11215
    ECgene: AKAP11 H-InvDB: AKAP11

    (According to HUGE)
    About This Section
    HUGE: KIAA0629

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AKAP11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AKAP11 gene:
    Search GeneIP for patents involving AKAP11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for AKAP11  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AKAP11   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AKAP11  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for AKAP11   OriGene 3'-UTR Clone for AKAP11  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AKAP11   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AKAP11  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AKAP11   OriGene Custom Protein Services for AKAP11  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AKAP11
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AKAP11
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AKAP11
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AKAP11
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AKAP11
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AKAP11
     GenScript Custom Purified and Recombinant Proteins Services for AKAP11 GenScript cDNA clones with any tag delivered in your preferred vector for AKAP11
     GenScript Custom Assay Services for AKAP11 GenScript Custom Superior Antibodies Services for AKAP11
     GenScript Custom overexpressing Cell Line Services for AKAP11 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in AKAP11 promoter
     Search Chromatin IP Primers for AKAP11
     RT2 qPCR Primer Assay in human, mouse, rat AKAP11
     GNC Network for AKAP11
     SABiosciences PCR Arrays including human, mouse, rat AKAP11
     Search Tocris compounds for AKAP11
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AKAP11 antibodies
     AKAP11 proteins
     Search for Antibodies for AKAP11 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for AKAP11
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     AKAP11 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for AKAP11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP11
     SwitchGear 3'UTR luciferase reporter plasmids for AKAP11
     SwitchGear Promoter luciferase reporter plasmids for AKAP11
     Search ThermoFisher Antibodies for AKAP11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKAP11
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AKAP11 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4