Aliases for AKAP10 Gene
External Ids for AKAP10 Gene
Previous GeneCards Identifiers for AKAP10 Gene
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]
GeneCards Summary for AKAP10 Gene
AKAP10 (A-Kinase Anchoring Protein 10) is a Protein Coding gene. Diseases associated with AKAP10 include cardiac conduction defect. Among its related pathways are Platelet activation, signaling and aggregation and Factors involved in megakaryocyte development and platelet production.
UniProtKB/Swiss-Prot for AKAP10 Gene
Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).