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Aliases for AKAP10 Gene

Aliases for AKAP10 Gene

  • A Kinase (PRKA) Anchor Protein 10 2 3
  • Mitochondrial A Kinase PPKA Anchor Protein 10 2 3
  • Dual Specificity A Kinase-Anchoring Protein 2 3 4
  • Protein Kinase A Anchoring Protein 10 2 3
  • D-AKAP-2 3 4
  • AKAP-10 3 4
  • PRKA10 3 4
  • Dual-Specificity A-Kinase Anchoring Protein 2 2
  • A-Kinase Anchor Protein 10, Mitochondrial 3
  • Protein Kinase A-Anchoring Protein 10 4
  • D-AKAP2 3

External Ids for AKAP10 Gene

Previous GeneCards Identifiers for AKAP10 Gene

  • GC17M019978
  • GC17M021445
  • GC17M019712
  • GC17M019970
  • GC17M019749
  • GC17M019192

Summaries for AKAP10 Gene

Entrez Gene Summary for AKAP10 Gene

  • This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]

GeneCards Summary for AKAP10 Gene

AKAP10 (A Kinase (PRKA) Anchor Protein 10) is a Protein Coding gene. Diseases associated with AKAP10 include cardiac conduction defect. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA.

UniProtKB/Swiss-Prot for AKAP10 Gene

  • Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).

Gene Wiki entry for AKAP10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP10 Gene

Genomics for AKAP10 Gene

Regulatory Elements for AKAP10 Gene

Genomic Location for AKAP10 Gene

Start:
19,904,302 bp from pter
End:
19,978,343 bp from pter
Size:
74,042 bases
Orientation:
Minus strand

Genomic View for AKAP10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKAP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP10 Gene

Proteins for AKAP10 Gene

  • Protein details for AKAP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43572-AKA10_HUMAN
    Recommended name:
    A-kinase anchor protein 10, mitochondrial
    Protein Accession:
    O43572
    Secondary Accessions:
    • B2R650
    • Q96AJ7

    Protein attributes for AKAP10 Gene

    Size:
    662 amino acids
    Molecular mass:
    73818 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for AKAP10 Gene

neXtProt entry for AKAP10 Gene

Proteomics data for AKAP10 Gene at MOPED

Post-translational modifications for AKAP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKAP10 Gene

No data available for DME Specific Peptides for AKAP10 Gene

Domains for AKAP10 Gene

Gene Families for AKAP10 Gene

HGNC:
  • AKAP :A-kinase anchor proteins

Protein Domains for AKAP10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AKAP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43572

UniProtKB/Swiss-Prot:

AKA10_HUMAN :
  • O43572
Domain:
  • RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer
  • Contains 2 RGS domains.
genes like me logo Genes that share domains with AKAP10: view

Function for AKAP10 Gene

Molecular function for AKAP10 Gene

GENATLAS Biochemistry: A kinase (PRKA regulatory subunits RIA and RIIA) anchor protein 10
UniProtKB/Swiss-Prot Function: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).

Phenotypes for AKAP10 Gene

genes like me logo Genes that share phenotypes with AKAP10: view

miRNA for AKAP10 Gene

miRTarBase miRNAs that target AKAP10

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for AKAP10 Gene

Localization for AKAP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP10 Gene

Mitochondrion. Membrane. Cytoplasm. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP10 Gene COMPARTMENTS Subcellular localization image for AKAP10 gene
Compartment Confidence
mitochondrion 5
cytosol 4
plasma membrane 4
nucleus 3

Gene Ontology (GO) - Cellular Components for AKAP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with AKAP10: view

Pathways for AKAP10 Gene

genes like me logo Genes that share pathways with AKAP10: view

Pathways by source for AKAP10 Gene

Gene Ontology (GO) - Biological Process for AKAP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9326583
GO:0007596 blood coagulation TAS --
GO:0008104 protein localization IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway --
GO:0038032 termination of G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with AKAP10: view

Compounds for AKAP10 Gene

(1) HMDB Compounds for AKAP10 Gene

Compound Synonyms Cas Number PubMed IDs
9-cis-Retinal
  • 9-cis-Retinal
514-85-2
genes like me logo Genes that share compounds with AKAP10: view

Transcripts for AKAP10 Gene

Unigene Clusters for AKAP10 Gene

A kinase (PRKA) anchor protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2: -
SP3: - -

Relevant External Links for AKAP10 Gene

GeneLoc Exon Structure for
AKAP10
ECgene alternative splicing isoforms for
AKAP10

Expression for AKAP10 Gene

mRNA expression in normal human tissues for AKAP10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKAP10 Gene

SOURCE GeneReport for Unigene cluster for AKAP10 Gene Hs.642676

genes like me logo Genes that share expressions with AKAP10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AKAP10 Gene

Orthologs for AKAP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for AKAP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKAP10 35
  • 97.51 (n)
  • 97.26 (a)
AKAP10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AKAP10 35
  • 90.41 (n)
  • 93.22 (a)
AKAP10 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKAP10 35
  • 94.21 (n)
  • 94.71 (a)
AKAP10 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akap10 35
  • 90.63 (n)
  • 89.73 (a)
Akap10 16
Akap10 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AKAP10 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKAP10 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akap10 35
  • 90.94 (n)
  • 90.94 (a)
chicken
(Gallus gallus)
Aves AKAP10 35
  • 80.96 (n)
  • 82.79 (a)
AKAP10 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKAP10 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13624 35
tropical clawed frog
(Silurana tropicalis)
Amphibia akap10 35
  • 71.59 (n)
  • 74.13 (a)
zebrafish
(Danio rerio)
Actinopterygii akap10 35
  • 64.87 (n)
  • 68.83 (a)
akap10 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007895 35
  • 43.67 (n)
  • 33.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta pkaap 35
  • 44.49 (n)
  • 32.83 (a)
pkaap 36
  • 23 (a)
OneToOne
pkaap 37
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea rgs-5 36
  • 26 (a)
OneToOne
Species with no ortholog for AKAP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AKAP10 Gene

ENSEMBL:
Gene Tree for AKAP10 (if available)
TreeFam:
Gene Tree for AKAP10 (if available)

Paralogs for AKAP10 Gene

No data available for Paralogs for AKAP10 Gene

Variants for AKAP10 Gene

Sequence variations from dbSNP and Humsavar for AKAP10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs6813 -- 19,905,132(-) ACTCC(A/G)TTGAC utr-variant-3-prime
rs119672 -- 19,915,288(-) TCTCT(C/T)TCCTT intron-variant
rs169411 -- 19,951,219(-) ctccc(A/G)gacgg intron-variant
rs169412 -- 19,948,562(-) ggcca(A/C)gACTT intron-variant
rs169413 -- 19,946,432(-) TTGTC(C/T)AGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKAP10 Gene

Variant ID Type Subtype PubMed ID
nsv907868 CNV Gain 21882294
nsv907869 CNV Loss 21882294
esv2715737 CNV Deletion 23290073
nsv833394 CNV Gain 17160897
nsv507837 CNV Insertion 20534489
esv1070888 CNV Deletion 17803354
nsv907870 CNV Gain 21882294

Relevant External Links for AKAP10 Gene

HapMap Linkage Disequilibrium report
AKAP10
Human Gene Mutation Database (HGMD)
AKAP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP10 Gene

Disorders for AKAP10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for AKAP10 Gene including...

Search for AKAP10 Gene in MalaCards »

(1) OMIM Diseases for AKAP10 Gene (604694)

UniProtKB/Swiss-Prot

AKA10_HUMAN
  • Sudden cardiac death (SCD) [MIM:115080]: Unexpected rapid death due to cardiovascular collapse in a short time period, generally within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. {ECO:0000269 PubMed:17485678}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.

Relevant External Links for AKAP10

Genetic Association Database (GAD)
AKAP10
Human Genome Epidemiology (HuGE) Navigator
AKAP10
genes like me logo Genes that share disorders with AKAP10: view

Publications for AKAP10 Gene

  1. Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. (PMID: 11248059) Wang L. … Taylor S.S. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23
  2. Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. (PMID: 12646697) Kammerer S. … Braun A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 23 48
  3. The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer. (PMID: 16956908) Wirtenberger M. … Burwinkel B. (Carcinogenesis 2007) 3 23 48
  4. Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. (PMID: 17485678) Tingley W.G. … Conklin B.R. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 23
  5. The Ile646Val (2073A>G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 and the risk of colorectal cancer. (PMID: 19209010) Wang M.J. … Sun X.F. (Oncology 2009) 3 23 48

Products for AKAP10 Gene

Sources for AKAP10 Gene

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