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AKAP10 Gene

protein-coding   GIFtS: 60
GCID: GC17M019807

A Kinase (PRKA) Anchor Protein 10

  See AKAP10-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
A Kinase (PRKA) Anchor Protein 101 2     PRKA102 3
Mitochondrial A Kinase PPKA Anchor Protein 101 2     Dual-Specificity A-Kinase Anchoring Protein 21
Protein Kinase A Anchoring Protein 101 2     D-AKAP22
Dual Specificity A Kinase-Anchoring Protein 22 3     A-Kinase Anchor Protein 10, Mitochondrial2
AKAP-102 3     Protein Kinase A-Anchoring Protein 103
D-AKAP-22 3     

External Ids:    HGNC: 3681   Entrez Gene: 112162   Ensembl: ENSG000001085997   OMIM: 6046945   UniProtKB: O435723   

Export aliases for AKAP10 gene to outside databases

Previous GC identifers: GC17M019978 GC17M021445 GC17M019712 GC17M019970 GC17M019749 GC17M019192


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AKAP10 Gene:
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory
subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded
protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA.
Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death.
(provided by RefSeq, May 2012)

GeneCards Summary for AKAP10 Gene:
AKAP10 (A kinase (PRKA) anchor protein 10) is a protein-coding gene. Diseases associated with AKAP10 include cardiac conduction defect.

UniProtKB/Swiss-Prot: AKA10_HUMAN, O43572
Function: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and
anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and
AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated
and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G
protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain,
it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the
downstream kinase (By similarity)

Gene Wiki entry for AKAP10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AKAP10 gene promoter:
         MAZR   GCNF   p300   GATA-2   E2F-1   E2F   GCNF-1   GCNF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAKAP10 promoter sequence
   Search Chromatin IP Primers for AKAP10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKAP10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.1   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.1

AKAP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKAP10 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M019807:  view genomic region     (about GC identifiers)

Start:
19,807,615 bp from pter      End:
19,881,656 bp from pter
Size:
74,042 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AKA10_HUMAN, O43572 (See protein sequence)
Recommended Name: A-kinase anchor protein 10, mitochondrial precursor  
Size: 662 amino acids; 73818 Da
2 PDB 3D structures from and Proteopedia for AKAP10:
3IM4 (3D)        3TMH (3D)    
Secondary accessions: B2R650 Q96AJ7

Explore the universe of human proteins at neXtProt for AKAP10: NX_O43572

Explore proteomics data for AKAP10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AKAP10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009133.2  
    ENSEMBL proteins: 
     ENSP00000225737   ENSP00000466329   ENSP00000378907   ENSP00000463398   ENSP00000464294  
     ENSP00000464079   ENSP00000461040   ENSP00000458637   ENSP00000461793  
    Reactome Protein details: O43572

    AKAP10 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AKAP: A-kinase anchor proteins

    2 InterPro protein domains:
     IPR016137 Regulat_G_prot_signal_superfam
     IPR000342 RGS_dom

    Graphical View of Domain Structure for InterPro Entry O43572

    ProtoNet protein and cluster: O43572

    UniProtKB/Swiss-Prot: AKA10_HUMAN, O43572
    Domain: RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein
    interactions with a complementary surface on the R-subunit dimer
    Similarity: Contains 2 RGS domains


    Find genes that share domains with AKAP10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKA10_HUMAN, O43572
    Function: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and
    anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and
    AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated
    and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G
    protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain,
    it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the
    downstream kinase (By similarity)

         Genatlas biochemistry entry for AKAP10:
    A kinase (PRKA regulatory subunits RIA and RIIA) anchor protein 10

    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Akap10):
     cardiovascular system  mortality/aging  nervous system 

    Find genes that share phenotypes with AKAP10           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for AKAP10

    miRNA
    Products:
        
    miRTarBase miRNAs that target AKAP10:
    hsa-mir-331-3p (MIRT043412), hsa-mir-339-5p (MIRT042793)

    Block miRNA regulation of human, mouse, rat AKAP10 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate AKAP10:
    hsa-miR-30c hsa-miR-30a hsa-miR-30b hsa-miR-628-3p hsa-miR-30d hsa-miR-219-5p hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidAKAP10 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AKA10_HUMAN, O43572: Mitochondrion. Membrane. Cytoplasm. Note=Predominantly mitochondrial but also membrane
    associated and cytoplasmic
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol4
    plasma membrane4
    nucleus3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with AKAP10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AKAP10 About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    3Hemostasis
    Hemostasis0.43
    4Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production


    Find genes that share SuperPaths with AKAP10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AKAP10
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 BioSystems Pathway for AKAP10
        G Protein Signaling Pathways

    1 Reactome Pathway for AKAP10
        Factors involved in megakaryocyte development and platelet production


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AKAP10
    Interactions:

        Search GeneGlobe Interaction Network for AKAP10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for AKAP10 (O435722, 3 ENSP000002257374) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAR1AP106442, 3, ENSP000003514104MINT-68409 I2D: score=6 STRING: ENSP00000351410
    PRKAR2AP138613, ENSP000002655634I2D: score=4 STRING: ENSP00000265563
    PRKAR2BP313233, ENSP000002657174I2D: score=2 STRING: ENSP00000265717
    SLC9A3R1O147453, ENSP000002626134I2D: score=2 STRING: ENSP00000262613
    HAX1O001653, ENSP000003290024I2D: score=1 STRING: ENSP00000329002
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9326583
    GO:0007596blood coagulation TAS--
    GO:0008104protein localization IEA--
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--

    Find genes that share ontologies with AKAP10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AKAP10 (AKA10)

    1 HMDB Compound for AKAP10    About this table
    CompoundSynonyms CAS #PubMed Ids
    9-cis-Retinal9-cis-Retinal (see all 5)514-85-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AKAP10 gene: 
    NM_007202.3  

    Unigene Cluster for AKAP10:

    A kinase (PRKA) anchor protein 10
    Hs.642676  [show with all ESTs]
    Unigene Representative Sequence: NM_007202
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225737(uc002gwo.3 uc002gwp.1 uc010cqw.1 uc010vze.1)
    ENST00000578898 ENST00000395536 ENST00000583951 ENST00000460046 ENST00000582611
    ENST00000474245 ENST00000572155 ENST00000572341 ENST00000576896 ENST00000571858

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    7 qRT-PCR Assays for microRNAs that regulate AKAP10:
    hsa-miR-30c hsa-miR-30a hsa-miR-30b hsa-miR-628-3p hsa-miR-30d hsa-miR-219-5p hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidAKAP10 3' UTR sequence
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat AKAP10
      QuantiFast Probe-based Assays in human, mouse, rat AKAP10

    Additional mRNA sequence: 

    AF037439.1 AK295180.1 AK308297.1 AK312438.1 BC017055.1 BC111518.1 DQ270159.1 U00957.1 

    8 DOTS entries:

    DT.454880  DT.91675912  DT.210512  DT.120916287  DT.120916295  DT.40249560  DT.95362933  DT.440631 

    Selected AceView cDNA sequences (see all 245):

    BF221910 F15209 AU279494 CD300615 F15213 BM473905 AI191333 AA643615 
    AI373507 N49089 BQ772616 CR607110 F15214 BQ937697 AA548977 CB321908 
    T17079 BM803701 AU121472 BQ378872 BC017055 AW028684 NM_007202 AW452153 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for AKAP10    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                                                    -                                       
    SP2:                                                  -                                                         
    SP3:                          -     -                                                                           


    ECgene alternative splicing isoforms for AKAP10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AKAP10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AKAP10 Expression
    About this image

    AKAP10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKAP10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.642676
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AKAP10 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akap101 , 5 A kinase (PRKA) anchor protein 101, 5 90.63(n)1
    89.73(a)1
      11 (37.96 cM)5
    566971  NM_019921.31  NP_064305.21 
     618713075 
    chicken
    (Gallus gallus)
    Aves AKAP101 A kinase (PRKA) anchor protein 10 80.96(n)
    82.79(a)
      417612  XM_415856.4  XP_415856.3 
    lizard
    (Anolis carolinensis)
    Reptilia AKAP106
    A kinase (PRKA) anchor protein 10
    78(a)
    1 ↔ 1
    GL343393.1(251701-269759)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.136242 Xenopus laevis transcribed sequence with weak similarity more 78.49(n)    BU910284.1 
    zebrafish
    (Danio rerio)
    Actinopterygii akap101 A kinase (PRKA) anchor protein 10 64.87(n)
    68.83(a)
      566920  XM_005165576.1  XP_005165633.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pkaap1 , 3 protein kinase A anchor protein3
    pkaap1
    26(a)3
    44.49(n)1
    32.83(a)1
      349571  NM_135939.21  NP_609783.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rgs-56
    Protein RGS-5, isoform a (rgs-5) mRNA, complete cd...
    26(a)
    1 ↔ 1
    III(5698436-5702302) WBGene00004348


    ENSEMBL Gene Tree for AKAP10 (if available)
    TreeFam Gene Tree for AKAP10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AKAP10 (see all 1512)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2034621,2,,4
    C,F,O,A,Hother119801226(-) GTGACA/GTTATG 2 I V mis143Minor allele frequency- C:0.00EA NA MN NS WA CSA EU 9419
    rs287568951,2
    F--19228405(+) ATATAA/TTATAT 1 -- int12Minor allele frequency- T:0.37NA 8
    rs40059381,2
    F,A--19228406(-) tatatT/Aatata 1 -- int12Minor allele frequency- A:0.50NA 8
    rs75030121,2
    C--19228407(+) ATATTA/TTATAT 1 -- int12Minor allele frequency- T:0.13NA 8
    rs99006331,2
    C--19228487(+) CATAAA/GAGAAG 1 -- int11Minor allele frequency- G:0.00NA 2
    rs99006401,2
    C,F--19228489(+) TAAGAG/AAAGGC 1 -- int11Minor allele frequency- A:0.50NA 4
    rs1463595861,2
    C--19228504(+) CCCAAC/TCTACA 1 -- int10--------
    rs676497701,2
    C--19228826(+) AAACTT/-TTTTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs353987791,2
    C--19231948(+) AAAAA-/ACGGTG 1 -- int12Minor allele frequency- A:0.25NA 4
    rs597043851,2
    C,F--19796180(+) CAACTT/CTAAAA 1 -- ds50012Minor allele frequency- C:0.09WA 120

    HapMap Linkage Disequilibrium report for AKAP10 (19807615 - 19881656 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for AKAP10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715737CNV Deletion23290073
    esv1070888CNV Deletion17803354
    nsv507837CNV Insertion20534489
    nsv907869CNV Loss21882294
    nsv907870CNV Gain21882294
    nsv907868CNV Gain21882294
    nsv833394CNV Gain17160897

    Human Gene Mutation Database (HGMD): AKAP10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AKAP10
    DNA2.0 Custom Variant and Variant Library Synthesis for AKAP10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604694   
    OMIM disorders: 115080  
    UniProtKB/Swiss-Prot: AKA10_HUMAN, O43572
  • Sudden cardiac death (SCD) [MIM:115080]: Unexpected rapid death due to cardiovascular collapse in a short
    time period, generally within one hour of initial symptoms. It is usually caused by the worsening of existing
    heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly
    ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death.
    Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Increased
    susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of
    low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability

  • 1 disease for AKAP10:    
    About MalaCards
    cardiac conduction defect


    Find genes that share disorders with AKAP10           About GenesLikeMe

    Genetic Association Database (GAD): AKAP10
    Human Genome Epidemiology (HuGE) Navigator: AKAP10 (13 documents)

    Export disorders for AKAP10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AKAP10 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with AKAP10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. (PubMed id 11248059)1, 2, 9 Wang L.... Taylor S.S. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    2. Association of the A1936G (rs203462) of A-kinase anchoring protein 10 polymorphisms with QT interval prolongation during kidney transplantation. (PubMed id 19857670)1, 4, 9 Zukowski M....BrykczyA8ski M. (Transplant. Proc. 2009)
    3. The Ile646Val (2073A&gt;G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 and the risk of colorectal cancer. (PubMed id 19209010)1, 4, 9 Wang M.J....Sun X.F. (Oncology 2009)
    4. The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer. (PubMed id 16956908)1, 4, 9 Wirtenberger M....Burwinkel B. (Carcinogenesis 2007)
    5. Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. (PubMed id 17485678)1, 2, 9 Tingley W.G.... Conklin B.R. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    6. Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. (PubMed id 12646697)1, 4, 9 Kammerer S....Braun A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    7. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    8. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    9. AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle-aged European-Americans. (PubMed id 19496216)1, 4 Neumann S.A....Manuck S.B. (Psychophysiology 2009)
    10. Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11216 HGNC: 368 AceView: AKAP10 Ensembl:ENSG00000108599 euGenes: HUgn11216
    ECgene: AKAP10 H-InvDB: AKAP10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AKAP10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AKAP10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AKAP10 gene:
    Search GeneIP for patents involving AKAP10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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