Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AKAP1 Gene

protein-coding   GIFtS: 62
GCID: GC17P055162

A Kinase (PRKA) Anchor Protein 1


(Previous symbol: PRKA1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
A Kinase (PRKA) Anchor Protein 11 2     AKAP2
PRKA11 2 3     AKAP1212
AKAP1492 3 5     AKAP842
Dual Specificity A-Kinase-Anchoring Protein 11 3     D-AKAP12
Tudor Domain Containing 171 2     PPP1R432
Spermatid A-Kinase Anchor Protein 842 3     TDRD172
D-AKAP-12 3     A-Kinase Anchor Protein 1, Mitochondrial2
A-Kinase Anchor Protein 149 KDa2 3     Dual-Specificity A-Kinase Anchoring Protein 12
AKAP 1492 3     Protein Kinase A Anchoring Protein 12
SAKAP842 5     Protein Kinase A12
Protein Kinase Anchoring Protein 11     Protein Phosphatase 1, Regulatory Subunit 432
Protein Phosphatase 11     S-AKAP843
Regulatory Subunit 431     Protein Kinase A-Anchoring Protein 13

External Ids:    HGNC: 3671   Entrez Gene: 81652   Ensembl: ENSG000001210577   OMIM: 6024495   UniProtKB: Q926673   

Export aliases for AKAP1 gene to outside databases

Previous GC identifers: GC17P054899 GC17P057644 GC17P055504 GC17P055637 GC17P052517 GC17P050523


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for AKAP1 Gene:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function
of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations
within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II
regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in
the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. (provided
by RefSeq, Jul 2008)

GeneCards Summary for AKAP1 Gene:
AKAP1 (A kinase (PRKA) anchor protein 1) is a protein-coding gene. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: AKAP1_HUMAN, Q92667
Function: Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face
of the mitochondrial outer membrane

Gene Wiki entry for AKAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AKAP1 gene promoter:
         USF1   AP-1   ATF-2   CUTL1   GATA-2   CREB   deltaCREB   USF-1   Sox9   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AKAP1 promoter sequence
   Search Chromatin IP Primers for AKAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q22

AKAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKAP1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P055162:  view genomic region     (about GC identifiers)

Start:
55,162,453 bp from pter      End:
55,198,710 bp from pter
Size:
36,258 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AKAP1_HUMAN, Q92667 (See protein sequence)
Recommended Name: A-kinase anchor protein 1, mitochondrial precursor  
Size: 903 amino acids; 97342 Da
Secondary accessions: A8K8Q1 D3DTZ0 Q13320 Q9BW14
Alternative splicing: 2 isoforms:  Q92667-1   Q92667-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for AKAP1: NX_Q92667

Explore proteomics data for AKAP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AKAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001229831.1  NP_001229832.1  NP_003479.1  

    ENSEMBL proteins: 
     ENSP00000459808   ENSP00000337736   ENSP00000459968   ENSP00000458982   ENSP00000461418  
     ENSP00000460557   ENSP00000458164   ENSP00000460209   ENSP00000459895   ENSP00000433212  
     ENSP00000443139   ENSP00000460514   ENSP00000459521   ENSP00000458378   ENSP00000461854  
     ENSP00000460762   ENSP00000458370   ENSP00000314075  
    Reactome Protein details: Q92667

    AKAP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for AKAP1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for AKAP1
    GenScript Custom Purified and Recombinant Proteins Services for AKAP1
    Novus Biologicals AKAP1 Protein
    Novus Biologicals AKAP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AKAP1

     
    Search eBioscience for Proteins for AKAP1 

    AKAP1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of AKAP1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for AKAP1 
    OriGene Antibodies for AKAP1
    OriGene Custom Antibody Services for AKAP1
    Novus Biologicals AKAP1 Antibodies
    Abcam antibodies for AKAP1
    Cloud-Clone Corp. Antibodies for AKAP1
    ThermoFisher Antibody for AKAP1
    LSBio Antibodies in human, mouse, rat for AKAP1

    AKAP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AKAP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AKAP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AKAP1
    Cloud-Clone Corp. CLIAs for AKAP1
    Search eBioscience for ELISAs for AKAP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
    TDRD: Tudor domain containing
    AKAP: A-kinase anchor proteins

    3 InterPro protein domains:
     IPR004087 KH_dom
     IPR004088 KH_dom_type_1
     IPR002999 Tudor

    Graphical View of Domain Structure for InterPro Entry Q92667

    ProtoNet protein and cluster: Q92667

    4 Blocks protein domains:
    IPB002999 Tudor domain
    IPB004087 KH domain
    IPB004088 KH
    IPB008191 Maternal tudor protein


    UniProtKB/Swiss-Prot: AKAP1_HUMAN, Q92667
    Domain: RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein
    interactions with a complementary surface on the R-subunit dimer
    Similarity: Contains 1 KH domain
    Similarity: Contains 1 Tudor domain


    Find genes that share domains with AKAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AKAP1_HUMAN, Q92667
    Function: Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face
    of the mitochondrial outer membrane

         Genatlas biochemistry entry for AKAP1:
    A kinase (PRKA regulatory subunit RIIA) anchor protein 1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS8769136
    GO:0005515protein binding IPI12223483
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with AKAP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AKAP1:
     PARP inhibitor sensitization 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Akap1):
     reproductive system 

    Find genes that share phenotypes with AKAP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Akap1tm1Gsm for AKAP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AKAP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AKAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AKAP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AKAP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target AKAP1:
    hsa-mir-877-5p (MIRT037317), hsa-mir-204-5p (MIRT005814)

    Block miRNA regulation of human, mouse, rat AKAP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AKAP1 (see all 42):
    hsa-let-7a-2* hsa-miR-301a hsa-miR-766 hsa-miR-507 hsa-miR-409-5p hsa-miR-4273 hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidAKAP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AKAP1
    Predesigned siRNA for gene silencing in human, mouse, rat AKAP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AKAP1

    Clone
    Products:
         
    OriGene clones in human, mouse for AKAP1 (see all 6)
    OriGene ORF clones in mouse, rat for AKAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AKAP1 (NM_003488)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKAP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AKAP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for AKAP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AKAP1_HUMAN, Q92667: Mitochondrion outer membrane (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion4
    cytoskeleton2
    plasma membrane2
    endoplasmic reticulum1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005741mitochondrial outer membrane IEA--
    GO:0005829cytosol TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with AKAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for AKAP1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    3Hemostasis
    Hemostasis0.43
    4Selected targets of ESR1
    Selected targets of ESR1
    5Proton Pump Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics


    Find genes that share SuperPaths with AKAP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AKAP1
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 Cell Signaling Technology (CST) Pathway for AKAP1
        Ca, cAMP and Lipid Signaling

    1 BioSystems Pathway for AKAP1
        G Protein Signaling Pathways

    1 Reactome Pathway for AKAP1
        Factors involved in megakaryocyte development and platelet production

    1 PharmGKB Pathway for AKAP1
        Proton Pump Inhibitor Pathway, Pharmacodynamics

        Pathway & Disease-focused RT2 Profiler PCR Array including AKAP1: 
              Estrogen Receptor Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AKAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for AKAP1 (Q926671, 2, 3 ENSP000003377364) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAR2AP138611, 2, 3, ENSP000002655634EBI-2119593,EBI-2556122 MINT-2411925 I2D: score=4 STRING: ENSP00000265563
    MYCBPQ994171, 3, ENSP000003807024EBI-2120060,EBI-716185 I2D: score=4 STRING: ENSP00000380702
    PRKAR1AP106442, 3, ENSP000003514104MINT-17792 I2D: score=4 STRING: ENSP00000351410
    AMY1AP047453, ENSP000003591004I2D: score=2 STRING: ENSP00000359100
    AMY1BP047453I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation TAS--

    Find genes that share ontologies with AKAP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AKAP1

    9 Novoseek inferred chemical compound relationships for AKAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 53.3 1 15143158 (1)
    potassium 11.5 1 15528278 (1)
    serine 3.74 4 16669629 (2), 8910553 (1)
    atp 2.57 5 16251349 (2), 8228907 (1), 7972090 (1), 10600928 (1)
    lipid 0 1 16856837 (1)
    steroid 0 1 12943713 (1)
    calcium 0 3 12709444 (1), 9620705 (1), 9247274 (1)
    tyrosine 0 5 16251349 (3), 15143158 (1), 12509440 (1)
    hydrogen 0 1 16260760 (1)



    Find genes that share compounds with AKAP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AKAP1 gene (4 alternative transcripts): 
    NM_001242902.1  NM_001242903.1  NM_003488.3  NM_139275.1  

    Unigene Cluster for AKAP1:

    A kinase (PRKA) anchor protein 1
    Hs.463506  [show with all ESTs]
    Unigene Representative Sequence: NM_001242903
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575322 ENST00000337714(uc002iux.3 uc010wnl.2) ENST00000571629
    ENST00000570423 ENST00000575186 ENST00000573085 ENST00000572814 ENST00000574683
    ENST00000572557 ENST00000481416(uc021uak.1 uc010dcm.3 uc002iuy.3)
    ENST00000539273 ENST00000576591 ENST00000572156 ENST00000576295 ENST00000573326
    ENST00000575032 ENST00000572560 ENST00000314126
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AKAP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AKAP1 (see all 42):
    hsa-let-7a-2* hsa-miR-301a hsa-miR-766 hsa-miR-507 hsa-miR-409-5p hsa-miR-4273 hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidAKAP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AKAP1
    Predesigned siRNA for gene silencing in human, mouse, rat AKAP1
    Clone
    Products:
         
    OriGene clones in human, mouse for AKAP1 (see all 6)
    OriGene ORF clones in mouse, rat for AKAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AKAP1 (NM_003488)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AKAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKAP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AKAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for AKAP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AKAP1
      QuantiTect SYBR Green Assays in human, mouse, rat AKAP1
      QuantiFast Probe-based Assays in human, mouse, rat AKAP1

    Additional mRNA sequence: 

    AK292416.1 AK297810.1 AK308397.1 BC000729.2 X97335.1 

    12 DOTS entries:

    DT.95125145  DT.40239465  DT.95184536  DT.120932653  DT.95125148  DT.120932644  DT.120932647  DT.120932635 
    DT.120932650  DT.120932656  DT.100789733  DT.101978716 

    Selected AceView cDNA sequences (see all 335):

    BM968946 BC000729 AI284936 BM772839 AI264546 CK906226 BM127048 Z38604 
    AI825239 BM765562 BU782997 BM742819 AA916893 BQ001492 AW752876 BQ689533 
    BU787835 BQ721084 BQ650895 CA440025 AA868550 CR594012 BM785005 BQ021521 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AKAP1 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:        -     -     -     -     -     -     -                                         -                                                                     
    SP2:                                            -                                                                                                               
    SP3:                                                                                      -                                                                     
    SP4:                                                                                                                                                            
    SP5:                                            -                                                                                                               


    ECgene alternative splicing isoforms for AKAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AKAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCACCTGTAG
    AKAP1 Expression
    About this image


    AKAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    AKAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AKAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.463506

    UniProtKB/Swiss-Prot: AKAP1_HUMAN, Q92667
    Tissue specificity: AKAP149 is highly expressed in prostate and small intestine whereas S-AKAP84 is expressed in
    kidney, pancreas, liver, lung and brain. AKAP149 is also expressed in colon carcinoma

        Pathway & Disease-focused RT2 Profiler PCR Array including AKAP1: 
              Estrogen Receptor Signaling in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AKAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for AKAP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AKAP1
    QuantiTect SYBR Green Assays in human, mouse, rat AKAP1
    QuantiFast Probe-based Assays in human, mouse, rat AKAP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for AKAP1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Akap11 , 5 A kinase (PRKA) anchor protein 11, 5 77.37(n)1
    71.51(a)1
      11 (54.34 cM)5
    116401  NM_009648.21  NP_033778.21 
     888307925 
    chicken
    (Gallus gallus)
    Aves AKAP11 A kinase (PRKA) anchor protein 1 57.06(n)
    51.81(a)
      417668  XM_415913.4  XP_415913.1 
    lizard
    (Anolis carolinensis)
    Reptilia AKAP16
    A kinase (PRKA) anchor protein 1
    73(a)
    1 ↔ 1
    GL343543.1(660-14337)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.100322 Transcribed sequence with moderate similarity to protein more 75.98(n)    137713903 
    zebrafish
    (Danio rerio)
    Actinopterygii akap12 A kinase (PRKA) anchor protein 1 76.2(n)   334904  BM860930.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta spoon6
    spoonbill
    24(a)
    1 ↔ 1
    X(5306419-5314896)
    worm
    (Caenorhabditis elegans)
    Secernentea C56G2.1a3   -- 33(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for AKAP1 (if available)
    TreeFam Gene Tree for AKAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for AKAP1 (see all 987)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483121421,2
    Cuntested156199084(+) AGAAAA/GGGAAC 6 K R mis10--------
    rs673453521,2
    C--50551110(+) CTCTC-/GCCCCT 3 -- int10--------
    rs2002621861,2
    C--55164158(+) AGTACC/TTTTTT 3 -- int10--------
    rs105955331,2
    C--55167836(+) TCCTC-/CTCTGCCC 3 -- int10--------
    rs38423681,2
    C--55176058(+) CAATTC/-CCAAG 3 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs58211611,2
    C--55186085(+) CTGAGA/-AGGGG 3 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs114645271,2
    C--55190230(+) GCTCTG/-CCCCC 3 -- int1 trp34Minor allele frequency- -:0.00NA CSA 10
    rs711399641,2
    C--55192273(+) TTTTT-/C/TCCCTC 3 -- int11NA 2
    rs38378021,2
    C--55195054(+) CCTCT-/CTGCTTC 3 -- int1 trp30--------
    rs58211621,2
    C--55197931(+) AAAAA-/AGGAAT 3 -- ut31 trp30--------

    HapMap Linkage Disequilibrium report for AKAP1 (55162453 - 55198710 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AKAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv111740CNV Loss16902084
    esv33941CNV Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AKAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for AKAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602449    OMIM disorders: --


    Find genes that share disorders with AKAP1           About GenesLikeMe

    1 Novoseek inferred disease relationship for AKAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cystic fibrosis 0.309 1 10600928 (1)

    Genetic Association Database (GAD): AKAP1
    Human Genome Epidemiology (HuGE) Navigator: AKAP1 (2 documents)

    Export disorders for AKAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AKAP1 gene, integrated from 10 sources (see all 161):
    (articles sorted by number of sources associating them with AKAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells. (PubMed id 7499250)1, 2, 3, 9 Lin R.-Y.... Rubin C.S. (J. Biol. Chem. 1995)
    2. Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain. (PubMed id 8769136)1, 2, 3, 9 Trendelenburg G.... Hanski C. (Biochem. Biophys. Res. Commun. 1996)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    5. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP- dependent protein kinase. (PubMed id 11483602)1, 9 Furusawa M.... Ariga H. (J. Biol. Chem. 2001)
    8. NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum. (PubMed id 10352013)1, 9 Huang L.J....Taylor S.S. (J. Cell Biol. 1999)
    9. Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network. (PubMed id 19074462)1, 9 Rogne M....KA1ntziger T. (Hum. Mol. Genet. 2009)
    10. Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia. (PubMed id 18323779)1, 9 Carlucci A....Feliciello A. (EMBO J. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8165 HGNC: 367 AceView: AKAP1 Ensembl:ENSG00000121057 euGenes: HUgn8165
    ECgene: AKAP1 H-InvDB: AKAP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for AKAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AKAP1 gene:
    Search GeneIP for patents involving AKAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of AKAP1
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for AKAP1   OriGene RNAi products in human, mouse, rat for AKAP1  
     OriGene qPCR primer pairs and template standards for AKAP1   OriGene Protein Over-expression Lysate for AKAP1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for AKAP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for AKAP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for AKAP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AKAP1   OriGene Custom Protein Services for AKAP1  

     
     
     Block miRNA regulation of human, mouse, rat AKAP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AKAP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AKAP1 Predesigned siRNA for gene silencing in human, mouse, rat AKAP1
     QuantiFast Probe-based Assays in human, mouse, rat AKAP1 QuantiTect SYBR Green Assays in human, mouse, rat AKAP1
     PCR Arrays including human, mouse, rat AKAP1 Search Chromatin IP Primers for AKAP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AKAP1  GeneGlobe Interaction Network for AKAP1
     Regulatory tfbs in AKAP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for AKAP1 GenScript cDNA clones with any tag delivered in your preferred vector for AKAP1
     GenScript Custom Assay Services for AKAP1 GenScript Custom overexpressing Cell Line Services for AKAP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for AKAP1 

     Search Tocris compounds for AKAP1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     AKAP1 antibodies
     AKAP1 proteins
     AKAP1 lysates
     Antibodies for AKAP1
     See all of Abcam's Antibodies, Kits and Proteins for AKAP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for AKAP1
     Antibodies for AKAP1
     ELISAs for AKAP1
     CLIAs for AKAP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for AKAP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AKAP1
     SwitchGear 3'UTR luciferase reporter plasmids for AKAP1
     SwitchGear Promoter luciferase reporter plasmids for AKAP1
     ThermoFisher Antibody for AKAP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AKAP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AKAP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AKAP1
     LSBio Antibodies in human, mouse, rat for AKAP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for AKAP1
      Search eBioscience for proteins for AKAP1
      Search eBioscience for elisas for AKAP1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AKAP1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4