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Aliases for AKAP1 Gene

Aliases for AKAP1 Gene

  • A Kinase (PRKA) Anchor Protein 1 2 3
  • AKAP149 3 4 6
  • Dual Specificity A-Kinase-Anchoring Protein 1 2 4
  • Spermatid A-Kinase Anchor Protein 84 3 4
  • A-Kinase Anchor Protein 149 KDa 3 4
  • Tudor Domain Containing 17 2 3
  • AKAP 149 3 4
  • D-AKAP-1 3 4
  • SAKAP84 3 6
  • PRKA1 3 4
  • Dual-Specificity A-Kinase Anchoring Protein 1 3
  • Protein Phosphatase 1, Regulatory Subunit 43 3
  • A-Kinase Anchor Protein 1, Mitochondrial 3
  • Protein Kinase A Anchoring Protein 1 3
  • Protein Kinase A-Anchoring Protein 1 4
  • Protein Kinase Anchoring Protein 1 2
  • Protein Phosphatase 1 2
  • Regulatory Subunit 43 2
  • Protein Kinase A1 3
  • S-AKAP84 4
  • AKAP121 3
  • D-AKAP1 3
  • PPP1R43 3
  • AKAP84 3
  • TDRD17 3
  • AKAP 3

External Ids for AKAP1 Gene

Previous HGNC Symbols for AKAP1 Gene

  • PRKA1

Previous GeneCards Identifiers for AKAP1 Gene

  • GC17P054899
  • GC17P057644
  • GC17P055504
  • GC17P055637
  • GC17P052517
  • GC17P055162
  • GC17P050523

Summaries for AKAP1 Gene

Entrez Gene Summary for AKAP1 Gene

  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKAP1 Gene

AKAP1 (A Kinase (PRKA) Anchor Protein 1) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for AKAP1 Gene

  • Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane

Gene Wiki entry for AKAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP1 Gene

Genomics for AKAP1 Gene

Regulatory Elements for AKAP1 Gene

Genomic Location for AKAP1 Gene

Start:
57,085,092 bp from pter
End:
57,121,349 bp from pter
Size:
36,258 bases
Orientation:
Plus strand

Genomic View for AKAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP1 Gene

Proteins for AKAP1 Gene

  • Protein details for AKAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92667-AKAP1_HUMAN
    Recommended name:
    A-kinase anchor protein 1, mitochondrial
    Protein Accession:
    Q92667
    Secondary Accessions:
    • A8K8Q1
    • D3DTZ0
    • Q13320
    • Q9BW14

    Protein attributes for AKAP1 Gene

    Size:
    903 amino acids
    Molecular mass:
    97342 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AKAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKAP1 Gene

Proteomics data for AKAP1 Gene at MOPED

Post-translational modifications for AKAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AKAP1 Gene

Domains for AKAP1 Gene

Gene Families for AKAP1 Gene

HGNC:
  • AKAP :A-kinase anchor proteins
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
  • TDRD :Tudor domain containing

Protein Domains for AKAP1 Gene

Suggested Antigen Peptide Sequences for AKAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92667

UniProtKB/Swiss-Prot:

AKAP1_HUMAN :
  • Q92667
Domain:
  • RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer
  • Contains 1 KH domain.
  • Contains 1 Tudor domain.
genes like me logo Genes that share domains with AKAP1: view

Function for AKAP1 Gene

Molecular function for AKAP1 Gene

GENATLAS Biochemistry: A kinase (PRKA regulatory subunit RIIA) anchor protein 1
UniProtKB/Swiss-Prot Function: Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane

Gene Ontology (GO) - Molecular Function for AKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 8769136
GO:0005515 protein binding IPI 12223483
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with AKAP1: view

Phenotypes for AKAP1 Gene

MGI mutant phenotypes for AKAP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for AKAP1:
genes like me logo Genes that share phenotypes with AKAP1: view

Animal Models for AKAP1 Gene

MGI Knock Outs for AKAP1:

miRNA for AKAP1 Gene

miRTarBase miRNAs that target AKAP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AKAP1 Gene

Localization for AKAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP1 Gene

Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP1 Gene COMPARTMENTS Subcellular localization image for AKAP1 gene
Compartment Confidence
cytosol 4
mitochondrion 4
cytoskeleton 2
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AKAP1: view

Pathways for AKAP1 Gene

genes like me logo Genes that share pathways with AKAP1: view

Pathways by source for AKAP1 Gene

1 Cell Signaling Technology pathway for AKAP1 Gene
1 BioSystems pathway for AKAP1 Gene

Gene Ontology (GO) - Biological Process for AKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with AKAP1: view

Compounds for AKAP1 Gene

(9) Novoseek inferred chemical compound relationships for AKAP1 Gene

Compound -log(P) Hits PubMed IDs
cyclic amp 53.3 1
potassium 11.5 1
serine 3.74 3
atp 2.57 5
lipid 0 1
genes like me logo Genes that share compounds with AKAP1: view

Transcripts for AKAP1 Gene

Unigene Clusters for AKAP1 Gene

A kinase (PRKA) anchor protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - - - -
SP2: -
SP3: -
SP4:
SP5: -
SP6: - - - - -
SP7: - - - -

Relevant External Links for AKAP1 Gene

GeneLoc Exon Structure for
AKAP1
ECgene alternative splicing isoforms for
AKAP1

Expression for AKAP1 Gene

mRNA expression in normal human tissues for AKAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKAP1 Gene

SOURCE GeneReport for Unigene cluster for AKAP1 Gene Hs.463506

mRNA Expression by UniProt/SwissProt for AKAP1 Gene

Q92667-AKAP1_HUMAN
Tissue specificity: AKAP149 is highly expressed in prostate and small intestine whereas S-AKAP84 is expressed in kidney, pancreas, liver, lung and brain. AKAP149 is also expressed in colon carcinoma
genes like me logo Genes that share expressions with AKAP1: view

No data available for mRNA differential expression in normal tissues for AKAP1 Gene

Orthologs for AKAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for AKAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKAP1 35
  • 99.04 (n)
  • 98.45 (a)
AKAP1 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AKAP1 35
  • 76.72 (n)
  • 74.14 (a)
AKAP1 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKAP1 35
  • 80.36 (n)
  • 77.65 (a)
AKAP1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Akap1 35
  • 77.37 (n)
  • 71.51 (a)
Akap1 16
Akap1 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia AKAP1 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akap1 35
  • 78.58 (n)
  • 72.41 (a)
chicken
(Gallus gallus)
Aves AKAP1 35
  • 57.06 (n)
  • 51.81 (a)
AKAP1 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKAP1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10032 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2949 35
zebrafish
(Danio rerio)
Actinopterygii akap1 35
akap1b 36
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta spoon 36
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea akap-1 36
  • 20 (a)
OneToOne
C56G2.1a 37
  • 33 (a)
C56G2.1b 37
  • 33 (a)
Species with no ortholog for AKAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AKAP1 Gene

ENSEMBL:
Gene Tree for AKAP1 (if available)
TreeFam:
Gene Tree for AKAP1 (if available)

Paralogs for AKAP1 Gene

No data available for Paralogs for AKAP1 Gene

Variants for AKAP1 Gene

Sequence variations from dbSNP and Humsavar for AKAP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4583 -- 57,120,441(+) TCTTT(A/C)TCCAT utr-variant-3-prime
rs6967 -- 57,121,059(+) AGATT(C/T)TTCCA utr-variant-3-prime
rs15944 -- 57,120,887(+) TAAAT(A/T)TGAAA utr-variant-3-prime
rs721425 -- 57,087,564(-) CTTTA(A/G)GACAG intron-variant
rs721426 -- 57,087,520(-) TTCCC(C/G)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKAP1 Gene

Variant ID Type Subtype PubMed ID
esv33941 CNV Loss 17666407
nsv111740 CNV Loss 16902084

Relevant External Links for AKAP1 Gene

HapMap Linkage Disequilibrium report
AKAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP1 Gene

Disorders for AKAP1 Gene

(1) Novoseek inferred disease relationships for AKAP1 Gene

Disease -log(P) Hits PubMed IDs
cystic fibrosis 0.309 1

Relevant External Links for AKAP1

Genetic Association Database (GAD)
AKAP1
Human Genome Epidemiology (HuGE) Navigator
AKAP1
genes like me logo Genes that share disorders with AKAP1: view

No data available for UniProtKB/Swiss-Prot for AKAP1 Gene

Publications for AKAP1 Gene

  1. Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells. (PMID: 7499250) Lin R.-Y. … Rubin C.S. (J. Biol. Chem. 1995) 2 3 4 23
  2. Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain. (PMID: 8769136) Trendelenburg G. … Hanski C. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23
  3. cAMP-dependent protein kinase A (PKA) signaling induces TNFR1 exosome-like vesicle release via anchoring of PKA regulatory subunit RIIbeta to BIG2. (PMID: 18625701) Islam A. … Levine S.J. (J. Biol. Chem. 2008) 3 23
  4. AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription. (PMID: 18786546) Lemay J. … Liu L.X. (J. Mol. Biol. 2008) 3 23
  5. AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase. (PMID: 12697839) Steen R.L. … Collas P. (J. Cell. Sci. 2003) 3 23

Products for AKAP1 Gene

Sources for AKAP1 Gene

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