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Aliases for AKAIN1 Gene

Aliases for AKAIN1 Gene

  • A Kinase (PRKA) Anchor Inhibitor 1 2 3
  • C18orf42 3 4 5
  • Chromosome 18 Open Reading Frame 42 2 5

External Ids for AKAIN1 Gene

Previous HGNC Symbols for AKAIN1 Gene

  • C18orf42

Summaries for AKAIN1 Gene

GeneCards Summary for AKAIN1 Gene

AKAIN1 (A Kinase (PRKA) Anchor Inhibitor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AKAIN1 Gene

  • Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA (PubMed:25653177).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAIN1 Gene

Genomics for AKAIN1 Gene

Regulatory Elements for AKAIN1 Gene

Enhancers for AKAIN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AKAIN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AKAIN1 Gene

5,143,673 bp from pter
5,198,203 bp from pter
54,531 bases
Minus strand

Genomic View for AKAIN1 Gene

Genes around AKAIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAIN1 Gene

Proteins for AKAIN1 Gene

  • Protein details for AKAIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A-kinase anchor protein C18orf42
    Protein Accession:

    Protein attributes for AKAIN1 Gene

    69 amino acids
    Molecular mass:
    7848 Da
    Quaternary structure:
    • Binds cAMP-dependent protein kinase (PKA). Interacts specifically with RII-regulatory subunits of PKA (PRKAR2A and PRKAR2B) (PubMed:25653177).

neXtProt entry for AKAIN1 Gene

Proteomics data for AKAIN1 Gene at MOPED

Post-translational modifications for AKAIN1 Gene

No Post-translational modifications

Other Protein References for AKAIN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AKAIN1 Gene

Domains & Families for AKAIN1 Gene

Protein Domains for AKAIN1 Gene


Graphical View of Domain Structure for InterPro Entry



  • The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
  • The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
genes like me logo Genes that share domains with AKAIN1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for AKAIN1 Gene

Function for AKAIN1 Gene

Molecular function for AKAIN1 Gene

UniProtKB/Swiss-Prot Function:
Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA (PubMed:25653177).

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKAIN1 Gene

Localization for AKAIN1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for AKAIN1 Gene

Pathways & Interactions for AKAIN1 Gene

SuperPathways for AKAIN1 Gene

No Data Available

Interacting Proteins for AKAIN1 Gene

Gene Ontology (GO) - Biological Process for AKAIN1 Gene


No data available for Pathways by source and SIGNOR curated interactions for AKAIN1 Gene

Drugs & Compounds for AKAIN1 Gene

No Compound Related Data Available

Transcripts for AKAIN1 Gene

mRNA/cDNA for AKAIN1 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AKAIN1 Gene

Chromosome 18 open reading frame 42:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKAIN1 Gene

No ASD Table

Relevant External Links for AKAIN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AKAIN1 Gene

SOURCE GeneReport for Unigene cluster for AKAIN1 Gene Hs.437160

mRNA Expression by UniProt/SwissProt for AKAIN1 Gene

Tissue specificity: Preferentially expressed in the neural tissues (PubMed:25653177).

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for AKAIN1 Gene

Orthologs for AKAIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAIN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia A330050F15Rik 35
  • 79.71 (n)
  • 76.81 (a)
Akain1 16
A330050F15Rik 36
  • 77 (a)
(Pan troglodytes)
Mammalia C18H18orf42 35
  • 99.03 (n)
  • 97.1 (a)
C18orf42 36
  • 97 (a)
(Rattus norvegicus)
Mammalia LOC100362606 35
  • 79.23 (n)
  • 79.71 (a)
(Canis familiaris)
Mammalia C18orf42 36
  • 88 (a)
(Gallus gallus)
Aves C18orf42 36
  • 72 (a)
Species with no ortholog for AKAIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AKAIN1 Gene

Gene Tree for AKAIN1 (if available)
Gene Tree for AKAIN1 (if available)

Paralogs for AKAIN1 Gene

No data available for Paralogs for AKAIN1 Gene

Variants for AKAIN1 Gene

Sequence variations from dbSNP and Humsavar for AKAIN1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs184123 -- 5,164,119(-) TTGCT(C/T)TAGAT intron-variant
rs186042 -- 5,165,644(+) TCCTT(A/C)ACAGA intron-variant
rs292264 -- 5,183,007(+) CTATT(A/G/T)TGCAA intron-variant
rs292265 -- 5,183,863(-) aatga(A/G)tcaac intron-variant
rs292266 -- 5,184,634(-) ctccc(C/T)ggtta intron-variant

Variation tolerance for AKAIN1 Gene

Gene Damage Index Score: 0.30; 6.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for AKAIN1 Gene

Disorders for AKAIN1 Gene

Relevant External Links for AKAIN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for AKAIN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKAIN1 Gene

Publications for AKAIN1 Gene

  1. Hypothetical gene C18orf42 encodes a novel protein kinase A-binding protein. (PMID: 25653177) Fukuda M. … Aizawa Y. (Genes Cells 2015) 2 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for AKAIN1 Gene

Sources for AKAIN1 Gene