Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AKAIN1 Gene

Aliases for AKAIN1 Gene

  • A-Kinase Anchor Inhibitor 1 2 3 5
  • A Kinase (PRKA) Anchor Inhibitor 1 2 3
  • C18orf42 3 4
  • Chromosome 18 Open Reading Frame 42 2
  • A-Kinase Anchor Protein Inhibitor 1 3
  • A-Kinase Anchor Protein C18orf42 3

External Ids for AKAIN1 Gene

Previous HGNC Symbols for AKAIN1 Gene

  • C18orf42

Summaries for AKAIN1 Gene

GeneCards Summary for AKAIN1 Gene

AKAIN1 (A-Kinase Anchor Inhibitor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AKAIN1 Gene

  • Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA (PubMed:25653177).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAIN1 Gene

Genomics for AKAIN1 Gene

Regulatory Elements for AKAIN1 Gene

Enhancers for AKAIN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F005293 1.5 FANTOM5 ENCODE 10.5 -98.3 -98271 5.8 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 LINC00667 AKAIN1 ZBTB14 GC18P005279
GH18F005236 1.2 ENCODE 11.1 -40.9 -40883 4.4 PKNOX1 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 LINC00667 AKAIN1 LINC00526 LOC100422274
GH18F005417 0.8 Ensembl ENCODE 9.5 -219.6 -219555 0.9 NFIL3 CEBPA HLF CEBPB CEBPG EPB41L3 AKAIN1 GC18P005414 GC18P005449
GH18F005318 0.3 FANTOM5 10.3 -120.4 -120425 0.3 AKAIN1 ZBTB14 ENSG00000264254 LOC105371970
GH18F005158 0.2 ENCODE 12.4 +39.1 39140 1.5 AKAIN1 BOD1P2 ENSG00000266153 GC18P005155
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AKAIN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AKAIN1 Gene

Chromosome:
18
Start:
5,143,673 bp from pter
End:
5,198,203 bp from pter
Size:
54,531 bases
Orientation:
Minus strand

Genomic View for AKAIN1 Gene

Genes around AKAIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKAIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKAIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAIN1 Gene

Proteins for AKAIN1 Gene

  • Protein details for AKAIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CW23-AKAI1_HUMAN
    Recommended name:
    A-kinase anchor protein inhibitor 1
    Protein Accession:
    P0CW23

    Protein attributes for AKAIN1 Gene

    Size:
    69 amino acids
    Molecular mass:
    7848 Da
    Quaternary structure:
    • Binds cAMP-dependent protein kinase (PKA). Interacts specifically with RII-regulatory subunits of PKA (PRKAR2A and PRKAR2B) (PubMed:25653177).

neXtProt entry for AKAIN1 Gene

Post-translational modifications for AKAIN1 Gene

No Post-translational modifications

Other Protein References for AKAIN1 Gene

No data available for DME Specific Peptides for AKAIN1 Gene

Domains & Families for AKAIN1 Gene

Protein Domains for AKAIN1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P0CW23

UniProtKB/Swiss-Prot:

AKAI1_HUMAN :
  • The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Domain:
  • The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
genes like me logo Genes that share domains with AKAIN1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for AKAIN1 Gene

Function for AKAIN1 Gene

Molecular function for AKAIN1 Gene

UniProtKB/Swiss-Prot Function:
Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA (PubMed:25653177).

Gene Ontology (GO) - Molecular Function for AKAIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034237 protein kinase A regulatory subunit binding IBA --
GO:0051018 protein kinase A binding IEA,IDA 25653177
genes like me logo Genes that share ontologies with AKAIN1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKAIN1 Gene

Localization for AKAIN1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AKAIN1 gene
Compartment Confidence
cytosol 5
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for AKAIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with AKAIN1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for AKAIN1 Gene

Pathways & Interactions for AKAIN1 Gene

SuperPathways for AKAIN1 Gene

No Data Available

Interacting Proteins for AKAIN1 Gene

Gene Ontology (GO) - Biological Process for AKAIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008104 protein localization IDA 25653177
GO:0010738 regulation of protein kinase A signaling IBA --
GO:0031333 negative regulation of protein complex assembly IEA --
genes like me logo Genes that share ontologies with AKAIN1: view

No data available for Pathways by source and SIGNOR curated interactions for AKAIN1 Gene

Transcripts for AKAIN1 Gene

mRNA/cDNA for AKAIN1 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AKAIN1 Gene

Chromosome 18 open reading frame 42:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKAIN1 Gene

No ASD Table

Relevant External Links for AKAIN1 Gene

GeneLoc Exon Structure for
AKAIN1
ECgene alternative splicing isoforms for
AKAIN1

Expression for AKAIN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of AKAIN1 Gene:

AKAIN1

SOURCE GeneReport for Unigene cluster for AKAIN1 Gene:

Hs.437160

mRNA Expression by UniProt/SwissProt for AKAIN1 Gene:

P0CW23-AKAI1_HUMAN
Tissue specificity: Preferentially expressed in the neural tissues (PubMed:25653177).

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for AKAIN1 Gene

Orthologs for AKAIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AKAIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C18H18orf42 34
  • 99.03 (n)
C18orf42 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C18orf42 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A330050F15Rik 34 35
  • 79.71 (n)
Akain1 16
rat
(Rattus norvegicus)
Mammalia LOC100362606 34
  • 79.23 (n)
chicken
(Gallus gallus)
Aves C18orf42 35
  • 72 (a)
OneToOne
Species where no ortholog for AKAIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AKAIN1 Gene

ENSEMBL:
Gene Tree for AKAIN1 (if available)
TreeFam:
Gene Tree for AKAIN1 (if available)

Paralogs for AKAIN1 Gene

No data available for Paralogs for AKAIN1 Gene

Variants for AKAIN1 Gene

Sequence variations from dbSNP and Humsavar for AKAIN1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1009818 -- 5,184,033(-) atttt(G/T)gtgtt intron-variant
rs10163862 -- 5,184,450(+) gtagt(C/T)gctgc intron-variant
rs10468761 -- 5,172,742(+) TACTG(C/T)TGAGG intron-variant
rs10601646 -- 5,200,205(+) TTTTT(-/T)GAGAC upstream-variant-2KB
rs10651301 -- 5,197,504(+) TTGTC(-/A/AA/AAAA/AAAAA)AAAAA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for AKAIN1 Gene

Variant ID Type Subtype PubMed ID
nsv523963 CNV loss 19592680
nsv476958 CNV novel sequence insertion 20440878
nsv1066095 CNV gain 25217958
esv3641646 CNV loss 21293372
esv3641645 CNV loss 21293372
esv2670046 CNV deletion 23128226
dgv3317n100 CNV gain 25217958
dgv184n21 CNV gain 19592680

Variation tolerance for AKAIN1 Gene

Gene Damage Index Score: 0.30; 6.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKAIN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AKAIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAIN1 Gene

Disorders for AKAIN1 Gene

Relevant External Links for AKAIN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKAIN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKAIN1

No disorders were found for AKAIN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AKAIN1 Gene

Publications for AKAIN1 Gene

  1. Hypothetical gene C18orf42 encodes a novel protein kinase A-binding protein. (PMID: 25653177) Fukuda M. … Aizawa Y. (Genes Cells 2015) 2 3 4 64
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  3. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for AKAIN1 Gene

Sources for AKAIN1 Gene

Content
Loading form....