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Aliases for AK9 Gene

Aliases for AK9 Gene

  • Adenylate Kinase 9 2 3 5
  • Adenylate Kinase Domain Containing 2 2 3
  • Adenylate Kinase Domain Containing 1 2 3
  • C6orf199 3 4
  • C6orf224 3 4
  • AK 9 3 4
  • AKD1 3 4
  • AKD2 3 4
  • Adenylate Kinase Domain-Containing Protein 1 4
  • Adenylate Kinase Domain-Containing Protein 2 4
  • Chromosome 6 Open Reading Frame 224 2
  • Chromosome 6 Open Reading Frame 199 2
  • EC 2.7.4.4 4
  • EC 2.7.4.6 4
  • DJ70A9.1 3

External Ids for AK9 Gene

Previous HGNC Symbols for AK9 Gene

  • C6orf224
  • AKD2
  • C6orf199
  • AKD1

Previous GeneCards Identifiers for AK9 Gene

  • GC06M109815

Summaries for AK9 Gene

GeneCards Summary for AK9 Gene

AK9 (Adenylate Kinase 9) is a Protein Coding gene. Among its related pathways are Purine metabolism and Metabolism. GO annotations related to this gene include nucleoside diphosphate kinase activity and nucleoside phosphate kinase activity.

UniProtKB/Swiss-Prot for AK9 Gene

  • Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AK9 Gene

Genomics for AK9 Gene

Regulatory Elements for AK9 Gene

Enhancers for AK9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AK9 on UCSC Golden Path with GeneCards custom track

Promoters for AK9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AK9 on UCSC Golden Path with GeneCards custom track

Genomic Location for AK9 Gene

Chromosome:
6
Start:
109,492,855 bp from pter
End:
109,691,217 bp from pter
Size:
198,363 bases
Orientation:
Minus strand

Genomic View for AK9 Gene

Genes around AK9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AK9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AK9 Gene

Proteins for AK9 Gene

  • Protein details for AK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TCS8-KAD9_HUMAN
    Recommended name:
    Adenylate kinase 9
    Protein Accession:
    Q5TCS8
    Secondary Accessions:
    • A6NL75
    • B2RDJ0
    • B6ZDM7
    • Q3MIS4
    • Q5I0W8
    • Q6ZNF1
    • Q6ZVR7
    • Q8N7C6
    • Q8WW00
    • Q96NF4

    Protein attributes for AK9 Gene

    Size:
    1911 amino acids
    Molecular mass:
    221413 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI01715.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI11949.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC05368.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for AK9 Gene

neXtProt entry for AK9 Gene

Proteomics data for AK9 Gene at MOPED

Post-translational modifications for AK9 Gene

No data available for DME Specific Peptides for AK9 Gene

Domains & Families for AK9 Gene

Gene Families for AK9 Gene

Protein Domains for AK9 Gene

Suggested Antigen Peptide Sequences for AK9 Gene

Graphical View of Domain Structure for InterPro Entry

Q5TCS8

UniProtKB/Swiss-Prot:

KAD9_HUMAN :
  • Belongs to the adenylate kinase family.
Family:
  • Belongs to the adenylate kinase family.
genes like me logo Genes that share domains with AK9: view

Function for AK9 Gene

Molecular function for AK9 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=48 uM for AMP (with ATP as phosphate donor) {ECO:0000269 PubMed:23416111}; KM=3600 uM for dAMP (with ATP as phosphate donor) {ECO:0000269 PubMed:23416111}; KM=940 uM for CMP (with ATP as phosphate donor) {ECO:0000269 PubMed:23416111};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside phosphate = ADP + nucleoside diphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function:
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP.

Enzyme Numbers (IUBMB) for AK9 Gene

Gene Ontology (GO) - Molecular Function for AK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with AK9: view
genes like me logo Genes that share phenotypes with AK9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AK9

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AK9 Gene

Localization for AK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AK9 Gene

Cytoplasm. Nucleus.

Gene Ontology (GO) - Cellular Components for AK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 23416111
GO:0005829 cytosol TAS --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with AK9: view

No data available for Subcellular locations from COMPARTMENTS for AK9 Gene

Pathways & Interactions for AK9 Gene

genes like me logo Genes that share pathways with AK9: view

Gene Ontology (GO) - Biological Process for AK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process IEA --
GO:0006174 dADP phosphorylation IDA 23416111
GO:0006757 ATP generation from ADP IDA 23416111
GO:0016310 phosphorylation IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with AK9: view

No data available for SIGNOR curated interactions for AK9 Gene

Drugs & Compounds for AK9 Gene

No Compound Related Data Available

Transcripts for AK9 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for AK9 Gene

No ASD Table

Relevant External Links for AK9 Gene

GeneLoc Exon Structure for
AK9
ECgene alternative splicing isoforms for
AK9

Expression for AK9 Gene

mRNA expression in normal human tissues for AK9 Gene

Protein differential expression in normal tissues from HIPED for AK9 Gene

This gene is overexpressed in Heart (50.0), Liver, secretome (8.2), and Urinary Bladder (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AK9 Gene



genes like me logo Genes that share expression patterns with AK9: view

Protein tissue co-expression partners for AK9 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AK9 Gene

Orthologs for AK9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AK9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AKD1 35
  • 85.48 (n)
  • 78.69 (a)
AK9 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AK9 35
  • 86.31 (n)
  • 80.46 (a)
AK9 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ak9 35
  • 76.89 (n)
  • 73.03 (a)
Ak9 16
Ak9 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AKD1 35
  • 99.44 (n)
  • 99.01 (a)
AK9 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1560386 35
  • 75.09 (n)
  • 71.98 (a)
oppossum
(Monodelphis domestica)
Mammalia AK9 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AK9 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves AKD1 35
  • 65.4 (n)
  • 55.46 (a)
AK9 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AK9 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ak9 35
  • 60.92 (n)
  • 53.01 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-199m3.4 35
  • 55.17 (n)
  • 46.99 (a)
ak9 36
  • 41 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
Species with no ortholog for AK9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AK9 Gene

ENSEMBL:
Gene Tree for AK9 (if available)
TreeFam:
Gene Tree for AK9 (if available)

Paralogs for AK9 Gene

(2) SIMAP similar genes for AK9 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with AK9: view

No data available for Paralogs for AK9 Gene

Variants for AK9 Gene

Sequence variations from dbSNP and Humsavar for AK9 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1096138 -- 109,680,567(+) ctagc(A/G)aggca intron-variant
rs1096139 -- 109,680,781(+) agaag(A/G)gagtg intron-variant
rs1096140 -- 109,680,947(+) aagga(A/G)gcact intron-variant
rs1096141 -- 109,681,360(+) ttaca(C/T)agtgg intron-variant
rs1096142 -- 109,681,449(+) agcaa(A/G)ttctt intron-variant

Variation tolerance for AK9 Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.15; 99.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AK9 Gene

Human Gene Mutation Database (HGMD)
AK9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AK9 Gene

Disorders for AK9 Gene

Relevant External Links for AK9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AK9

No disorders were found for AK9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AK9 Gene

Publications for AK9 Gene

  1. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. (PMID: 23416111) Amiri M. … Solaroli N. (Int. J. Biochem. Cell Biol. 2013) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities. (PMID: 20602751) Docherty S.J. … Plomin R. (BMC Genet. 2010) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for AK9 Gene

Sources for AK9 Gene

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