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Aliases for AK9 Gene

Aliases for AK9 Gene

  • Adenylate Kinase 9 2 3
  • Adenylate Kinase Domain Containing 2 2 3
  • Adenylate Kinase Domain Containing 1 2 3
  • C6orf199 3 4
  • C6orf224 3 4
  • AK 9 3 4
  • AKD1 3 4
  • AKD2 3 4
  • Adenylate Kinase Domain-Containing Protein 1 4
  • Adenylate Kinase Domain-Containing Protein 2 4
  • Chromosome 6 Open Reading Frame 224 2
  • Chromosome 6 Open Reading Frame 199 2
  • EC 2.7.4.4 4
  • EC 2.7.4.6 4
  • DJ70A9.1 3

External Ids for AK9 Gene

Previous HGNC Symbols for AK9 Gene

  • C6orf224
  • AKD2
  • C6orf199
  • AKD1

Previous GeneCards Identifiers for AK9 Gene

  • GC06M109815

Summaries for AK9 Gene

GeneCards Summary for AK9 Gene

AK9 (Adenylate Kinase 9) is a Protein Coding gene. GO annotations related to this gene include nucleoside-triphosphatase activity and nucleoside phosphate kinase activity.

UniProtKB/Swiss-Prot for AK9 Gene

  • Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AK9 Gene

Genomics for AK9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AK9 Gene

Start:
109,492,856 bp from pter
End:
109,691,217 bp from pter
Size:
198,362 bases
Orientation:
Minus strand

Genomic View for AK9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AK9 Gene

No data available for Regulatory Elements for AK9 Gene

Proteins for AK9 Gene

  • Protein details for AK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TCS8-KAD9_HUMAN
    Recommended name:
    Adenylate kinase 9
    Protein Accession:
    Q5TCS8
    Secondary Accessions:
    • A6NL75
    • B2RDJ0
    • B6ZDM7
    • Q3MIS4
    • Q5I0W8
    • Q6ZNF1
    • Q6ZVR7
    • Q8N7C6
    • Q8WW00
    • Q96NF4

    Protein attributes for AK9 Gene

    Size:
    1911 amino acids
    Molecular mass:
    221413 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI01715.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI11949.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC05368.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for AK9 Gene

neXtProt entry for AK9 Gene

Proteomics data for AK9 Gene at MOPED

Post-translational modifications for AK9 Gene

No data available for DME Specific Peptides for AK9 Gene

Domains for AK9 Gene

Protein Domains for AK9 Gene

Graphical View of Domain Structure for InterPro Entry

Q5TCS8

UniProtKB/Swiss-Prot:

KAD9_HUMAN :
  • Q5TCS8
Family:
  • Belongs to the adenylate kinase family.
genes like me logo Genes that share domains with AK9: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for AK9 Gene

Function for AK9 Gene

Molecular function for AK9 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=48 uM for AMP (with ATP as phosphate donor) {ECO:0000269 PubMed:23416111}; KM=3600 uM for dAMP (with ATP as phosphate donor) {ECO:0000269 PubMed:23416111}; KM=940 uM for CMP (with ATP as phosphate donor) {ECO:0000269 PubMed:23416111};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + nucleoside phosphate = ADP + nucleoside diphosphate.
UniProtKB/Swiss-Prot CatalyticActivity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP.

Enzyme Numbers (IUBMB) for AK9 Gene

Gene Ontology (GO) - Molecular Function for AK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity IDA 23416111
GO:0005524 ATP binding IEA --
GO:0019205 nucleobase-containing compound kinase activity --
GO:0050145 nucleoside phosphate kinase activity IDA 23416111
genes like me logo Genes that share ontologies with AK9: view

Phenotypes for AK9 Gene

GenomeRNAi human phenotypes for AK9:
genes like me logo Genes that share phenotypes with AK9: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AK9 Gene

Localization for AK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AK9 Gene

Cytoplasm. Nucleus.

Gene Ontology (GO) - Cellular Components for AK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 23416111
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with AK9: view

No data available for Subcellular locations from COMPARTMENTS for AK9 Gene

Pathways for AK9 Gene

SuperPathways for AK9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process --
GO:0006174 dADP phosphorylation IDA 23416111
GO:0006186 dGDP phosphorylation IDA 23416111
GO:0006756 AMP phosphorylation IDA 23416111
GO:0006757 ADP phosphorylation IDA 23416111
genes like me logo Genes that share ontologies with AK9: view

No data available for Pathways by source for AK9 Gene

Transcripts for AK9 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AK9

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for AK9
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AK9 Gene

No ASD Table

Relevant External Links for AK9 Gene

GeneLoc Exon Structure for
AK9
ECgene alternative splicing isoforms for
AK9

Expression for AK9 Gene

mRNA expression in normal human tissues for AK9 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AK9 Gene

genes like me logo Genes that share expressions with AK9: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AK9 Gene

Orthologs for AK9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AK9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AK9 36
  • 99 (a)
OneToOne
AKD1 35
  • 99.44 (n)
  • 99.01 (a)
cow
(Bos Taurus)
Mammalia AK9 36
  • 74 (a)
OneToOne
AKD1 35
  • 85.48 (n)
  • 78.69 (a)
dog
(Canis familiaris)
Mammalia AK9 35
  • 86.31 (n)
  • 80.46 (a)
AK9 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ak9 35
  • 76.89 (n)
  • 73.03 (a)
Ak9 36
  • 55 (a)
OneToOne
Akd1 16
oppossum
(Monodelphis domestica)
Mammalia AK9 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AK9 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1560386 35
  • 75.09 (n)
  • 71.98 (a)
chicken
(Gallus gallus)
Aves AK9 36
  • 53 (a)
OneToOne
AKD1 35
  • 65.4 (n)
  • 55.46 (a)
lizard
(Anolis carolinensis)
Reptilia AK9 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ak9 35
  • 60.92 (n)
  • 53.01 (a)
zebrafish
(Danio rerio)
Actinopterygii ak9 36
  • 41 (a)
OneToOne
si:ch211-199m3.4 35
  • 55.17 (n)
  • 46.99 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
Species with no ortholog for AK9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AK9 Gene

ENSEMBL:
Gene Tree for AK9 (if available)
TreeFam:
Gene Tree for AK9 (if available)

Paralogs for AK9 Gene

Selected SIMAP similar genes for AK9 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with AK9: view

No data available for Paralogs for AK9 Gene

Variants for AK9 Gene

Sequence variations from dbSNP and Humsavar for AK9 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs729888 -- 109,636,120(+) TGACT(C/T)GAAAG intron-variant
rs731878 -- 109,661,525(-) AACTA(A/C/G)GCCTA intron-variant
rs731879 -- 109,661,281(-) GATGG(A/G)TCTTA intron-variant
rs749517 -- 109,531,713(+) CATAT(A/G)AATGT intron-variant
rs829813 -- 109,673,107(+) AGTTG(C/T)TATAT intron-variant

Relevant External Links for AK9 Gene

HapMap Linkage Disequilibrium report
AK9
Human Gene Mutation Database (HGMD)
AK9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AK9 Gene

Disorders for AK9 Gene

No disorders were found for AK9 Gene.

No data available for UniProtKB/Swiss-Prot for AK9 Gene

Publications for AK9 Gene

  1. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. (PMID: 23416111) Amiri M. … Solaroli N. (Int. J. Biochem. Cell Biol. 2013) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for AK9 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate AK9
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for AK9
    • Block miRNA regulation of AK9 using miScript Target Protectors

    Sources for AK9 Gene

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