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Aliases for AK8 Gene

Aliases for AK8 Gene

  • Adenylate Kinase 8 2 3
  • ATP-AMP Transphosphorylase 8 3 4
  • C9orf98 3 4
  • AK 8 3 4
  • Putative Adenylate Kinase-Like Protein C9orf98 3
  • Chromosome 9 Open Reading Frame 98 2
  • EC 2.7.4.3 4
  • EC 2.7.4.6 4
  • DDX31 3

External Ids for AK8 Gene

Previous HGNC Symbols for AK8 Gene

  • C9orf98

Previous GeneCards Identifiers for AK8 Gene

  • GC09M135601

Summaries for AK8 Gene

GeneCards Summary for AK8 Gene

AK8 (Adenylate Kinase 8) is a Protein Coding gene. Among its related pathways are purine nucleotide salvage and purine nucleotide salvage. GO annotations related to this gene include nucleoside diphosphate kinase activity and cytidylate kinase activity. An important paralog of this gene is AK3.

UniProtKB/Swiss-Prot for AK8 Gene

  • Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AK8 Gene

Genomics for AK8 Gene

Genomic Location for AK8 Gene

Start:
132,725,571 bp from pter
End:
132,878,811 bp from pter
Size:
153,241 bases
Orientation:
Minus strand

Genomic View for AK8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AK8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AK8 Gene

No data available for Regulatory Elements for AK8 Gene

Proteins for AK8 Gene

  • Protein details for AK8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MA6-KAD8_HUMAN
    Recommended name:
    Adenylate kinase 8
    Protein Accession:
    Q96MA6
    Secondary Accessions:
    • A8K821
    • Q8N9W9

    Protein attributes for AK8 Gene

    Size:
    479 amino acids
    Molecular mass:
    54926 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AK8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AK8 Gene

Proteomics data for AK8 Gene at MOPED

Post-translational modifications for AK8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AK8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AK8 Gene

Domains for AK8 Gene

Gene Families for AK8 Gene

HGNC:
  • AK :Adenylate kinases

Protein Domains for AK8 Gene

Suggested Antigen Peptide Sequences for AK8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MA6

UniProtKB/Swiss-Prot:

KAD8_HUMAN :
  • Q96MA6
Family:
  • Belongs to the adenylate kinase family.
genes like me logo Genes that share domains with AK8: view

Function for AK8 Gene

Molecular function for AK8 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=4.1 uM for AMP {ECO:0000269 PubMed:21080915}; KM=630 uM for dAMP {ECO:0000269 PubMed:21080915}; KM=1.4 uM for CMP {ECO:0000269 PubMed:21080915}; Vmax=2400 pmol/min/ug enzyme with AMP as substrate {ECO:0000269 PubMed:21080915}; Vmax=1360 pmol/min/ug enzyme with dAMP as substrate {ECO:0000269 PubMed:21080915}; Vmax=190 pmol/min/ug enzyme with CMP as substrate {ECO:0000269 PubMed:21080915};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + AMP = 2 ADP
UniProtKB/Swiss-Prot CatalyticActivity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
UniProtKB/Swiss-Prot Function: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.

Enzyme Numbers (IUBMB) for AK8 Gene

Gene Ontology (GO) - Molecular Function for AK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004017 adenylate kinase activity IDA 21080915
GO:0004127 cytidylate kinase activity IDA 21080915
GO:0004550 nucleoside diphosphate kinase activity IDA 23416111
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with AK8: view
genes like me logo Genes that share phenotypes with AK8: view

miRNA for AK8 Gene

miRTarBase miRNAs that target AK8

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for AK8 Gene

Localization for AK8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AK8 Gene

Cytoplasm, cytosol.

Gene Ontology (GO) - Cellular Components for AK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with AK8: view

No data available for Subcellular locations from COMPARTMENTS for AK8 Gene

Pathways for AK8 Gene

genes like me logo Genes that share pathways with AK8: view

Gene Ontology (GO) - Biological Process for AK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IDA 23416111
GO:0009142 nucleoside triphosphate biosynthetic process IDA 23416111
GO:0021591 ventricular system development IEA --
genes like me logo Genes that share ontologies with AK8: view

Compounds for AK8 Gene

(1) Drugbank Compounds for AK8 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Bis(Adenosine)-5'-Pentaphosphate
target
genes like me logo Genes that share compounds with AK8: view

Transcripts for AK8 Gene

Unigene Clusters for AK8 Gene

Adenylate kinase 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AK8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - -
SP2: - - -
SP3: -
SP4: - -
SP5:

Relevant External Links for AK8 Gene

GeneLoc Exon Structure for
AK8
ECgene alternative splicing isoforms for
AK8

Expression for AK8 Gene

mRNA expression in normal human tissues for AK8 Gene

mRNA differential expression in normal tissues according to GTEx for AK8 Gene

This gene is overexpressed in Testis (13.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AK8 Gene

SOURCE GeneReport for Unigene cluster for AK8 Gene Hs.421340

genes like me logo Genes that share expressions with AK8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for AK8 Gene

Orthologs for AK8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AK8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AK8 35
  • 99.1 (n)
  • 99.16 (a)
AK8 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AK8 35
  • 83.72 (n)
  • 82.25 (a)
AK8 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AK8 35
  • 84.9 (n)
  • 81.84 (a)
AK8 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ak8 35
  • 78.38 (n)
  • 77.2 (a)
Ak8 16
Ak8 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AK8 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AK8 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ak8 35
  • 77.75 (n)
  • 76.99 (a)
chicken
(Gallus gallus)
Aves AK8 35
  • 64.14 (n)
  • 58.23 (a)
AK8 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AK8 36
  • 56 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16566 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ak8 35
  • 61.59 (n)
  • 54.07 (a)
MGC76170 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3842 35
zebrafish
(Danio rerio)
Actinopterygii ak8 35
  • 55.3 (n)
  • 47.79 (a)
ak8 36
  • 46 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADK2 36
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AMK2 35
  • 45.11 (n)
  • 37.31 (a)
rice
(Oryza sativa)
Liliopsida Os08g0109300 35
  • 47.12 (n)
  • 38.46 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.855 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for AK8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AK8 Gene

ENSEMBL:
Gene Tree for AK8 (if available)
TreeFam:
Gene Tree for AK8 (if available)

Paralogs for AK8 Gene

Paralogs for AK8 Gene

genes like me logo Genes that share paralogs with AK8: view

Variants for AK8 Gene

Sequence variations from dbSNP and Humsavar for AK8 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs71147 -- 132,812,866(-) GTGAG(C/T)GGGTC intron-variant
rs106906 -- 132,797,819(-) GAGCC(A/G)CCCAT intron-variant
rs108994 -- 132,801,925(-) gattg(A/G)ctgga intron-variant
rs172541 -- 132,803,461(-) CCATC(A/G)TCATC intron-variant
rs172542 -- 132,799,493(-) GGGGC(A/G)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AK8 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
nsv512122 CNV Loss 21212237
esv23761 CNV Loss 19812545
esv2669233 CNV Deletion 23128226
nsv517306 CNV Loss 19592680
nsv894024 CNV Gain 21882294
nsv416899 CNV Insertion 16902084
esv1077930 CNV Insertion 17803354
esv1992766 CNV Deletion 18987734
esv2739141 CNV Deletion 23290073
esv2739142 CNV Deletion 23290073
nsv831743 CNV Loss 17160897
esv2739143 CNV Deletion 23290073
esv2739144 CNV Deletion 23290073
esv2739145 CNV Deletion 23290073
esv1023755 CNV Deletion 17803354
nsv510206 CNV Loss 20534489

Relevant External Links for AK8 Gene

HapMap Linkage Disequilibrium report
AK8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AK8 Gene

Disorders for AK8 Gene

No disorders were found for AK8 Gene.

No data available for UniProtKB/Swiss-Prot for AK8 Gene

Publications for AK8 Gene

  1. The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes. (PMID: 21080915) Panayiotou C. … Karlsson A. (Biochem. J. 2011) 2 3 4
  2. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. (PMID: 23416111) Amiri M. … Solaroli N. (Int. J. Biochem. Cell Biol. 2013) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PMID: 18839057) Lesch K.P. … Jacob C. (J Neural Transm 2008) 3

Products for AK8 Gene

  • Addgene plasmids for AK8

Sources for AK8 Gene

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