Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AK8 Gene

protein-coding   GIFtS: 49
GCID: GC09M135601

Adenylate Kinase 8

(Previous name: chromosome 9 open reading frame 98)
(Previous symbol: C9orf98)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Adenylate Kinase 81 2     DDX312
C9orf981 2 3     Putative Adenylate Kinase-Like Protein C9orf982
AK 82 3     EC 2.7.4.33
ATP-AMP Transphosphorylase 82 3     EC 2.7.4.63
Chromosome 9 Open Reading Frame 981     

External Ids:    HGNC: 265261   Entrez Gene: 1580672   Ensembl: ENSG000001656957   OMIM: 6153655   UniProtKB: Q96MA63   

Export aliases for AK8 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for AK8 Gene:
AK8 (adenylate kinase 8) is a protein-coding gene. Diseases associated with AK8 include major depressive disorder, and obesity. GO annotations related to this gene include nucleoside diphosphate kinase activity and cytidylate kinase activity. An important paralog of this gene is AK3.

UniProtKB/Swiss-Prot: KAD8_HUMAN, Q96MA6
Function: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate
group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity
toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for AK8
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAK8 promoter sequence
   Search Chromatin IP Primers for AK8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AK8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13   Ensembl cytogenetic band:  9q34.13   HGNC cytogenetic band: 9q34.13

AK8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AK8 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M135601:  view genomic region     (about GC identifiers)

Start:
135,600,965 bp from pter      End:
135,754,198 bp from pter
Size:
153,234 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KAD8_HUMAN, Q96MA6 (See protein sequence)
Recommended Name: Adenylate kinase 8  
Size: 479 amino acids; 54926 Da
Secondary accessions: A8K821 Q8N9W9
Alternative splicing: 2 isoforms:  Q96MA6-1   Q96MA6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AK8: NX_Q96MA6

Explore proteomics data for AK8 at MOPED


See AK8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689785.1  
ENSEMBL proteins: 
 ENSP00000298545  

AK8 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for AK8
OriGene Custom MassSpec
OriGene Custom Protein Services for AK8
GenScript Custom Purified and Recombinant Proteins Services for AK8
Novus Biologicals AK8 Proteins
Novus Biologicals AK8 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for AK8

AK8 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for AK8
OriGene Custom Antibody Services for AK8
Novus Biologicals AK8 Antibodies
Abcam antibodies for AK8
Cloud-Clone Corp. Antibodies for AK8
ThermoFisher Antibodies for AK8
LSBio Antibodies in human, mouse, rat for AK8

AK8 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for AK8
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for AK8
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for AK8
Cloud-Clone Corp. CLIAs for AK8


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
AK: Adenylate kinases

3 InterPro protein domains:
 IPR000850 Adenylat/UMP-CMP_kin
 IPR007862 Adenylate_kinase_lid-dom
 IPR027417 P-loop_NTPase

Graphical View of Domain Structure for InterPro Entry Q96MA6

ProtoNet protein and cluster: Q96MA6

1 Blocks protein domain: IPB000850 Adenylate kinase

UniProtKB/Swiss-Prot: KAD8_HUMAN, Q96MA6
Similarity: Belongs to the adenylate kinase family


AK8 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: KAD8_HUMAN, Q96MA6
Function: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate
group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity
toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity
Catalytic activity: ATP + AMP = 2 ADP
Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
Biophysicochemical properties: Kinetic parameters: KM=4.1 uM for AMP; KM=630 uM for dAMP; KM=1.4 uM for CMP;
Vmax=2400 pmol/min/ug enzyme with AMP as substrate; Vmax=1360 pmol/min/ug enzyme with dAMP as substrate; Vmax=190
pmol/min/ug enzyme with CMP as substrate;

     Enzyme Numbers (IUBMB): EC 2.7.4.61 EC 2.7.4.31

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004017adenylate kinase activity IDA--
GO:0004127cytidylate kinase activity IDA--
GO:0004550nucleoside diphosphate kinase activity IDA--
GO:0005524ATP binding IEA--
     
AK8 for ontologies           About GeneDecksing


Phenotypes:
     3 GenomeRNAi human phenotypes for AK8:
 G0/1 arrest  Increased G1 DNA content  Weaker migration 

     5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ak8):
 behavior/neurological  craniofacial  growth/size/body  nervous system  reproductive system 

AK8 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AK8
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AK8

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AK8
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AK8

miRNA
Products:
    
miRTarBase miRNAs that target AK8:
hsa-mir-877-3p (MIRT037156), hsa-mir-16-5p (MIRT031816)

Block miRNA regulation of human, mouse, rat AK8 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate AK8
SwitchGear 3'UTR luciferase reporter plasmidAK8 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for AK8
Predesigned siRNA for gene silencing in human, mouse, rat AK8

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for AK8

Clone
Products:
     
OriGene clones in human, mouse for AK8 (see all 5)
OriGene ORF clones in mouse, rat for AK8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: AK8 (NM_152572)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for AK8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AK8

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for AK8
Browse ESI BIO Cell Lines and PureStem Progenitors for AK8 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AK8


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
KAD8_HUMAN, Q96MA6: Cytoplasm, cytosol

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005829cytosol IEA--

AK8 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for AK8 About    
See pathways by source

SuperPathContained pathways About
1purine nucleotide salvage
purine nucleotide salvage0.78
adenosine ribonucleotides de novo biosynthesis0.51
purine nucleotides de novo biosynthesis0.78


3 BioSystems Pathways for AK8
    purine nucleotides de novo biosynthesis
purine nucleotide salvage
adenosine ribonucleotides de novo biosynthesis


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AK8
Interactions:

    Search GeneGlobe Interaction Network for AK8

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

Selected Interacting proteins for AK8 (ENSP000002985454) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
InteractantInteraction Details
GeneCardExternal ID(s)
CMPK2ENSP000002567224STRING: ENSP00000256722
DTYMKENSP000003048024STRING: ENSP00000304802
BICC1ENSP000003629934STRING: ENSP00000362993
HDLBPENSP000003120424STRING: ENSP00000312042
AK1ENSP000003622494STRING: ENSP00000362249
About this table

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006165nucleoside diphosphate phosphorylation IDA--
GO:0009142nucleoside triphosphate biosynthetic process IDA--
GO:0021591ventricular system development IEA--

AK8 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for AK8 (KAD8)

1 DrugBank Compound for AK8    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Bis(Adenosine)-5'-Pentaphosphate-- --target--17139284 17016423 10592235



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for AK8 gene: 
NM_152572.2  

Unigene Cluster for AK8:

Adenylate kinase 8
Hs.421340  [show with all ESTs]
Unigene Representative Sequence: BC037402
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000298545(uc004cbu.1) ENST00000477396(uc010mzx.1) ENST00000476719(uc004cbv.1)
ENST00000467161 ENST00000482422
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat AK8 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate AK8
SwitchGear 3'UTR luciferase reporter plasmidAK8 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for AK8
Predesigned siRNA for gene silencing in human, mouse, rat AK8
Clone
Products:
     
OriGene clones in human, mouse for AK8 (see all 5)
OriGene ORF clones in mouse, rat for AK8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: AK8 (NM_152572)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for AK8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AK8
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for AK8
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AK8
  QuantiTect SYBR Green Assays in human, mouse, rat AK8
  QuantiFast Probe-based Assays in human, mouse, rat AK8

Additional mRNA sequence: 

AK057266.1 AK093446.1 AK292186.1 BC034776.1 BC037402.1 BC050576.1 

10 DOTS entries:

DT.203791  DT.100019553  DT.100748848  DT.101981125  DT.97804340  DT.86848944  DT.100648345  DT.75118489 
DT.95079216  DT.121161578 

Selected AceView cDNA sequences (see all 46):

BX091015 BX100680 AK057266 BC037402 AK093333 BU617945 AI368484 BC034776 
BI828586 AI362274 AX748132 BM983192 AX748058 BC050576 AA580077 AK093446 
BI767614 AI359456 NM_152572 CD515464 BM684476 AL040403 AW008827 AA861038 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for AK8    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1:                    -     -                                                                       -               
SP2:                    -                             -                                               -               
SP3:                                                  -                                                               
SP4:                                                                                            -     -               
SP5:                                                                                                                  


ECgene alternative splicing isoforms for AK8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

AK8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGATCCAGG
AK8 Expression
About this image

AK8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

AK8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.421340
    Custom PCR Arrays for AK8
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for AK8
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AK8
QuantiTect SYBR Green Assays in human, mouse, rat AK8
QuantiFast Probe-based Assays in human, mouse, rat AK8
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AK8

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of eukaryotes.

Orthologs for AK8 gene from Selected species (see all 18)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ak81 , 5 adenylate kinase 81, 5 78.38(n)1
77.2(a)1
  2 (19.38 cM)5
688701  NM_001033874.21  NP_001029046.21 
 287001645 
chicken
(Gallus gallus)
Aves AK81 adenylate kinase 8 64.14(n)
58.23(a)
  430522  XM_428077.4  XP_428077.3 
lizard
(Anolis carolinensis)
Reptilia AK86
adenylate kinase 8
56(a)
1 ↔ 1
GL343916.1(101076-102512)
African clawed frog
(Xenopus laevis)
Amphibia Xl.165662 Xenopus laevis transcribed sequence with weak similarity more 73.72(n)    CB207268.1 
zebrafish
(Danio rerio)
Actinopterygii ak81 adenylate kinase 8 55.3(n)
47.79(a)
  553671  NM_001020644.1  NP_001018480.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADK26
Mitochondrial adenylate kinase, catalyzes the reve...
24(a)
1 → many
V(525974-526651) YER170W
thale cress
(Arabidopsis thaliana)
eudicotyledons AMK21 AMK2 45.11(n)
37.31(a)
  834835  NM_124158.3  NP_199595.1 
rice
(Oryza sativa)
Liliopsida Os08g01093001 Os08g0109300 47.12(n)
38.46(a)
  4344470  NM_001067345.1  NP_001060810.1 


ENSEMBL Gene Tree for AK8 (if available)
TreeFam Gene Tree for AK8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for AK8 gene
AK32  AK42  

AK8 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for AK8 (see all 3180)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1927316641,2
--135600468(+) TGGGAC/TTACAG 1 -- int10--------
rs1847075071,2
--135600487(+) CACCAC/TGCCCA 1 -- int10--------
rs70363191,2
C--135600572(+) gatccA/Gcacgc 1 -- int10--------
rs1891632471,2
--135600577(+) ACACGC/TCTCGG 1 -- int10--------
rs70395331,2
C,F,A--135600588(+) cctccC/Taaagt 1 -- int13Minor allele frequency- T:0.33WA CSA 6
rs1455238481,2
--135600632(+) CCAAGA/GTGGGT 1 -- int10--------
rs70196091,2
C,F,A,H--135600687(+) gcgctA/Gagatc 1 -- int117Minor allele frequency- N:0.01NS EA NA WA CSA 998
rs1920259771,2
--135600699(+) TCATCA/GGCATC 1 -- int10--------
rs1411938211,2
C--135600813(+) CATGCA/GTTGGT 1 -- int10--------
rs1470902651,2
--135600859(+) AGACCC/TGGCCT 1 -- int10--------

HapMap Linkage Disequilibrium report for AK8 (135600965 - 135754198 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for AK8 (see all 17):    About this table    
Variant IDTypeSubtypePubMed ID
esv2739141CNV Deletion23290073
esv2739144CNV Deletion23290073
esv2739142CNV Deletion23290073
esv2669233CNV Deletion23128226
esv1992766CNV Deletion18987734
esv2739145CNV Deletion23290073
esv2739143CNV Deletion23290073
esv2739138CNV Deletion23290073
esv1023755CNV Deletion17803354
esv1077930CNV Insertion17803354

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing AK8
DNA2.0 Custom Variant and Variant Library Synthesis for AK8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 615365    OMIM disorders: --

2 diseases for AK8:    
About MalaCards
major depressive disorder    obesity


AK8 for disorders           About GeneDecksing


Export disorders for AK8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for AK8 gene, integrated from 10 sources (see all 16):
(articles sorted by number of sources associating them with AK8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes. (PubMed id 21080915)1, 2, 3 Panayiotou C.... Karlsson A. (Biochem. J. 2011)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. (PubMed id 23416111)2 Amiri M....Solaroli N. (amp 2013)
  4. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. (PubMed id 23377640)1 (Am J Psychiatry 2013)
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
  6. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
  7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  8. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (Gut 2009)
  9. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1 Lesch K.P....Jacob C. (J Neural Transm 2008)
  10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 158067 HGNC: 26526 AceView: C9orf98 Ensembl:ENSG00000165695 euGenes: HUgn158067
ECgene: AK8 H-InvDB: AK8

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for AK8 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for AK8 gene:
Search GeneIP for patents involving AK8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for AK8   OriGene RNAi products in human, mouse, rat for AK8  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for AK8  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for AK8  
 OriGene qSTAR qPCR primer pairs in human, mouse for AK8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for AK8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for AK8   OriGene Custom Protein Services for AK8  

 
 
 Block miRNA regulation of human, mouse, rat AK8 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AK8
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AK8 Predesigned siRNA for gene silencing in human, mouse, rat AK8
 QuantiFast Probe-based Assays in human, mouse, rat AK8 QuantiTect SYBR Green Assays in human, mouse, rat AK8
 Custom PCR Arrays for AK8 Search Chromatin IP Primers for AK8
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AK8  Search GeneGlobe Interaction Network for AK8
 Search Regulatory tfbs for AK8
 GenScript Custom Purified and Recombinant Proteins Services for AK8 GenScript cDNA clones with any tag delivered in your preferred vector for AK8
 GenScript Custom Assay Services for AK8 GenScript Custom overexpressing Cell Line Services for AK8
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for AK8 (KAD8)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 AK8 antibodies
 AK8 proteins
 AK8 lysates
 Antibodies for AK8
 See all of Abcam's Antibodies, Kits and Proteins for AK8
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for AK8
 Antibodies for AK8
 ELISAs for AK8
 CLIAs for AK8



 Browse ESI BIO Cell Lines and PureStem Progenitors for AK8
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AK8
 SwitchGear 3'UTR luciferase reporter plasmids for AK8
 SwitchGear Promoter luciferase reporter plasmids for AK8
 ThermoFisher Antibodies for AK8
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AK8
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AK8
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AK8
 LSBio Antibodies in human, mouse, rat for AK8
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      AK8 gene at Home site.
Version: 3.12.142 28 July 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4