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Aliases for AK8 Gene

Aliases for AK8 Gene

  • Adenylate Kinase 8 2 3 5
  • ATP-AMP Transphosphorylase 8 3 4
  • C9orf98 3 4
  • AK 8 3 4
  • Putative Adenylate Kinase-Like Protein C9orf98 3
  • Chromosome 9 Open Reading Frame 98 2
  • EC 2.7.4.3 4
  • EC 2.7.4.6 4
  • DDX31 3

External Ids for AK8 Gene

Previous HGNC Symbols for AK8 Gene

  • C9orf98

Previous GeneCards Identifiers for AK8 Gene

  • GC09M135601

Summaries for AK8 Gene

GeneCards Summary for AK8 Gene

AK8 (Adenylate Kinase 8) is a Protein Coding gene. Among its related pathways are Purine metabolism and Metabolism. GO annotations related to this gene include nucleoside diphosphate kinase activity and cytidylate kinase activity. An important paralog of this gene is AK2.

UniProtKB/Swiss-Prot for AK8 Gene

  • Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AK8 Gene

Genomics for AK8 Gene

Regulatory Elements for AK8 Gene

Enhancers for AK8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AK8 on UCSC Golden Path with GeneCards custom track

Promoters for AK8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AK8 on UCSC Golden Path with GeneCards custom track

Genomic Location for AK8 Gene

Chromosome:
9
Start:
132,725,574 bp from pter
End:
132,878,811 bp from pter
Size:
153,238 bases
Orientation:
Minus strand

Genomic View for AK8 Gene

Genes around AK8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AK8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AK8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AK8 Gene

Proteins for AK8 Gene

  • Protein details for AK8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MA6-KAD8_HUMAN
    Recommended name:
    Adenylate kinase 8
    Protein Accession:
    Q96MA6
    Secondary Accessions:
    • A8K821
    • Q8N9W9

    Protein attributes for AK8 Gene

    Size:
    479 amino acids
    Molecular mass:
    54926 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AK8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AK8 Gene

Proteomics data for AK8 Gene at MOPED

Post-translational modifications for AK8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AK8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AK8 Gene

Domains & Families for AK8 Gene

Gene Families for AK8 Gene

Protein Domains for AK8 Gene

Suggested Antigen Peptide Sequences for AK8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MA6

UniProtKB/Swiss-Prot:

KAD8_HUMAN :
  • Belongs to the adenylate kinase family.
Family:
  • Belongs to the adenylate kinase family.
genes like me logo Genes that share domains with AK8: view

Function for AK8 Gene

Molecular function for AK8 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=4.1 uM for AMP {ECO:0000269 PubMed:21080915}; KM=630 uM for dAMP {ECO:0000269 PubMed:21080915}; KM=1.4 uM for CMP {ECO:0000269 PubMed:21080915}; Vmax=2400 pmol/min/ug enzyme with AMP as substrate {ECO:0000269 PubMed:21080915}; Vmax=1360 pmol/min/ug enzyme with dAMP as substrate {ECO:0000269 PubMed:21080915}; Vmax=190 pmol/min/ug enzyme with CMP as substrate {ECO:0000269 PubMed:21080915};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + AMP = 2 ADP.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function:
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.

Enzyme Numbers (IUBMB) for AK8 Gene

Gene Ontology (GO) - Molecular Function for AK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004017 adenylate kinase activity IDA 21080915
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with AK8: view
genes like me logo Genes that share phenotypes with AK8: view

Animal Model Products

CRISPR Products

miRNA for AK8 Gene

miRTarBase miRNAs that target AK8

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AK8 Gene

Localization for AK8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AK8 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AK8 Gene COMPARTMENTS Subcellular localization image for AK8 gene
Compartment Confidence
cytosol 5
chloroplast 2
mitochondrion 2
cytoskeleton 1
extracellular 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for AK8 Gene

Pathways & Interactions for AK8 Gene

genes like me logo Genes that share pathways with AK8: view

Gene Ontology (GO) - Biological Process for AK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009165 nucleotide biosynthetic process EXP 10215863
GO:0015949 nucleobase-containing small molecule interconversion TAS --
GO:0021591 ventricular system development IEA --
genes like me logo Genes that share ontologies with AK8: view

No data available for SIGNOR curated interactions for AK8 Gene

Drugs & Compounds for AK8 Gene

(3) Drugs for AK8 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Bis(Adenosine)-5'-Pentaphosphate Experimental Pharma Target 0

(1) Additional Compounds for AK8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with AK8: view

Transcripts for AK8 Gene

Unigene Clusters for AK8 Gene

Adenylate kinase 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AK8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - -
SP2: - - -
SP3: -
SP4: - -
SP5:

Relevant External Links for AK8 Gene

GeneLoc Exon Structure for
AK8
ECgene alternative splicing isoforms for
AK8

Expression for AK8 Gene

mRNA expression in normal human tissues for AK8 Gene

mRNA differential expression in normal tissues according to GTEx for AK8 Gene

This gene is overexpressed in Testis (x13.0).

Protein differential expression in normal tissues from HIPED for AK8 Gene

This gene is overexpressed in Testis (44.9) and Brain (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AK8 Gene



SOURCE GeneReport for Unigene cluster for AK8 Gene Hs.421340

genes like me logo Genes that share expression patterns with AK8: view

Protein tissue co-expression partners for AK8 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for AK8 Gene

Orthologs for AK8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AK8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AK8 35
  • 83.72 (n)
  • 82.25 (a)
AK8 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AK8 35
  • 84.9 (n)
  • 81.84 (a)
AK8 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ak8 35
  • 78.38 (n)
  • 77.2 (a)
Ak8 16
Ak8 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AK8 35
  • 99.1 (n)
  • 99.16 (a)
AK8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ak8 35
  • 77.75 (n)
  • 76.99 (a)
oppossum
(Monodelphis domestica)
Mammalia AK8 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AK8 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves AK8 35
  • 64.14 (n)
  • 58.23 (a)
AK8 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AK8 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ak8 35
  • 61.59 (n)
  • 54.07 (a)
MGC76170 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16566 35
zebrafish
(Danio rerio)
Actinopterygii ak8 35
  • 55.3 (n)
  • 47.79 (a)
ak8 36
  • 46 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3842 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADK2 36
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AMK2 35
  • 45.11 (n)
  • 37.31 (a)
rice
(Oryza sativa)
Liliopsida Os08g0109300 35
  • 47.12 (n)
  • 38.46 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.855 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for AK8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AK8 Gene

ENSEMBL:
Gene Tree for AK8 (if available)
TreeFam:
Gene Tree for AK8 (if available)

Paralogs for AK8 Gene

Paralogs for AK8 Gene

genes like me logo Genes that share paralogs with AK8: view

Variants for AK8 Gene

Sequence variations from dbSNP and Humsavar for AK8 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_030873 -
rs17407084 - 132,854,870(+) TGCAA(C/T)CCTCT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs675851 -- 132,815,948(-) GGAAT(A/G)AATCC intron-variant
rs693692 -- 132,730,103(-) TAGGC(A/C)CCTCC intron-variant
rs717141 -- 132,861,884(-) GATGA(A/G)AGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AK8 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
nsv512122 CNV Loss 21212237
esv23761 CNV Loss 19812545
esv2669233 CNV Deletion 23128226
nsv517306 CNV Loss 19592680
nsv894024 CNV Gain 21882294
nsv416899 CNV Insertion 16902084
esv1077930 CNV Insertion 17803354
esv1992766 CNV Deletion 18987734
esv2739141 CNV Deletion 23290073
esv2739142 CNV Deletion 23290073
nsv831743 CNV Loss 17160897
esv2739143 CNV Deletion 23290073
esv2739144 CNV Deletion 23290073
esv2739145 CNV Deletion 23290073
esv1023755 CNV Deletion 17803354
nsv510206 CNV Loss 20534489

Variation tolerance for AK8 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.58; 65.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AK8 Gene

Disorders for AK8 Gene

Relevant External Links for AK8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AK8

No disorders were found for AK8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AK8 Gene

Publications for AK8 Gene

  1. The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes. (PMID: 21080915) Panayiotou C. … Karlsson A. (Biochem. J. 2011) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. (PMID: 23377640) (Am J Psychiatry 2013) 3
  4. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. (PMID: 23416111) Amiri M. … Solaroli N. (Int. J. Biochem. Cell Biol. 2013) 3
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3

Products for AK8 Gene

Sources for AK8 Gene

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