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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AK8 Gene

protein-coding GIFtS: 45
GCID: GC09M135601

adenylate kinase 8

(Previous name: chromosome 9 open reading frame 98 )
(Previous symbol: C9orf98)

Explore 1 disease affiliated with
AK8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adenylate Kinase 8¹ ²		DDX31²
C9orf98¹ ² ³		RP11-143F18.1²
FLJ32704¹		Putative Adenylate Kinase-Like Protein C9orf98²
Chromosome 9 Open Reading Frame 98¹		EC 2.7.4.3³

External Ids:	HGNC: 26526¹	Entrez Gene: 158067²	Ensembl: ENSG00000165695⁷	UniProtKB: Q96MA6³

Export aliases for AK8 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KAD8_HUMAN, Q96MA6

Function: Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_035014.4

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for AK8
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AK8 promoter sequence

Search SABiosciences Chromatin IP Primers for AK8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AK8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13 Ensembl cytogenetic band: 9q34.13 HGNC cytogenetic band: 9q34.13

AK8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AK8 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M135601: view genomic region (about GC identifiers)

Start:	135,600,965 bp from pter	End:	135,754,198 bp from pter
Size:	153,234 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KAD8_HUMAN, Q96MA6 (See protein sequence)

Recommended Name: Adenylate kinase 8

Size: 479 amino acids; 54926 Da

Subcellular location: Cytoplasm, cytosol

Secondary accessions: A8K821 Q8N9W9

Alternative splicing: 2 isoforms: Q96MA6-1 Q96MA6-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AK8: NX_Q96MA6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96MA6

AK8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689785.1

ENSEMBL proteins:

ENSP00000298545

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	Uscn Proteins for AK8

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	IEA	--

AK8 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AK8 for domains About GeneDecksing

3 InterPro domains/families:

IPR000850 Adenylate_kin

IPR007862 Adenylate_kinase_lid-dom

IPR026867 AK7/AK8

Graphical View of Domain Structure for InterPro Entry Q96MA6

ProtoNet protein and cluster: Q96MA6

1 Blocks protein family: IPB000850 Adenylate kinase

UniProtKB/Swiss-Prot: KAD8_HUMAN, Q96MA6

Similarity: Belongs to the adenylate kinase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KAD8_HUMAN, Q96MA6

Function: Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP

Catalytic activity: ATP + AMP = 2 ADP

Biophysicochemical properties: Kinetic parameters: KM=4.1 uM for AMP; KM=630 uM for dAMP; KM=1.4 uM for CMP; Vmax=2400

pmol/min/ug enzyme with AMP as substrate; Vmax=1360 pmol/min/ug enzyme with dAMP as substrate; Vmax=190 pmol/min/ug

enzyme with CMP as substrate;

Enzyme Number (IUBMB): EC 2.7.4.3¹

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AK8

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004017	adenylate kinase activity	IDA	--
GO:0004127	cytidylate kinase activity	IDA	--
GO:0005524	ATP binding	IEA	--

AK8 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for AK8:

G0/1 arrest

Increased G1 DNA content

Weaker migration

Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ak8):

behavior/neurological

craniofacial

growth/size

nervous system

reproductive system

AK8 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for AK8

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0021591	ventricular system development	IEA	--

AK8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AK8

1 DrugBank Compound for AK8 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Bis(Adenosine)-5'-Pentaphosphate	--	--	target	--	17139284 17016423 10592235

Search CenterWatch for drugs/clinical trials and news about AK8 / KAD8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for AK8 gene:

NM_152572.2

Unigene Cluster for AK8:

Adenylate kinase 8

Hs.421340 [show with all ESTs]

Unigene Representative Sequence: BC037402

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000298545(uc004cbu.1) ENST00000477396(uc010mzx.1) ENST00000476719(uc004cbv.1)

ENST00000467161 ENST00000482422

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Additional cDNA sequence:

AK057266.1 AK093446.1 AK292186.1 BC034776.1 BC037402.1 BC050576.1

10 DOTS entries:

DT.203791 DT.100019553 DT.100748848 DT.101981125 DT.97804340 DT.86848944 DT.100648345 DT.75118489

DT.95079216 DT.121161578

24/46 AceView cDNA sequences (see all 46):

AI368484 BM684476 AI362274 AX748132 BI828586 BM983192 AI359456 BC037402

BC050576 BX100680 AA580077 AX748058 AK057266 BC034776 NM_152572 BI767614

BX091015 CD515464 AK093446 BU617945 AK093333 BM926674 AL040402 AL040403

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for AK8 About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15
SP1:							-		-																								-
SP2:							-										-																-
SP3:																	-
SP4:																															-		-
SP5:

ECgene alternative splicing isoforms for AK8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AK8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGATCCAGG

About this image

AK8 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See AK8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AK8

SOURCE GeneReport for Unigene cluster: Hs.421340

SABiosciences Custom PCR Arrays for AK8

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for AK8 gene from 8/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ak8^{1 , 5}	adenylate kinase 8^{1, 5}	78.38(n)¹ 77.2(a)¹		2 (19.38 cM)⁵ 68870¹ NM_001033874.2¹ NP_001029046.2¹ 28700164⁵
chicken (Gallus gallus)	Aves	AK8¹	adenylate kinase 8	64.14(n) 58.23(a)		430522 XM_428077.3 XP_428077.3
lizard (Anolis carolinensis)	Reptilia	AK8⁶	--	56(a)	1 ↔ 1	GL343916.1(101076-102512)
African clawed frog (Xenopus laevis)	Amphibia	Xl.16566²	Xenopus laevis transcribed sequence with weak similarity more	73.72(n)		CB207268.1
zebrafish (Danio rerio)	Actinopterygii	ak8¹	adenylate kinase 8	55.16(n) 47.37(a)		553671 NM_001020644.1 NP_001018480.1
honey bee (Apis mellifera)	Insecta	--	--	13(a)	1 ↔ 1	Group3.27(320150-322246)
thale cress (Arabidopsis thaliana)	eudicotyledons	AMK2¹	adenosine monophosphate kinase	44.71(n) 36.54(a)		834835 NM_124158.3 NP_199595.1
rice (Oryza sativa)	Liliopsida	Os08g0109300¹	hypothetical protein	47.12(n) 38.46(a)		4344470 NM_001067345.1 NP_001060810.1

ENSEMBL Gene Tree for AK8 (if available)
TreeFam Gene Tree for AK8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AK8 gene

AK3² AK4²

AK8 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5900989^1,2	C	--	105096842(+)	`TGTGT-/CCCCCCA`	1	--	int¹		3		NA CSA	6
rs11284702^1,2	C	--	105201460(+)	`CATTT-/AAAAAA`	1	--	int¹ trp³		1		NA	2
rs192731664^1,2		--	135600468(+)	`TGGGAC/TTACAG`	1	--	int¹		0	--	--	--	--
rs184707507^1,2		--	135600487(+)	`CACCAC/TGCCCA`	1	--	int¹		0	--	--	--	--
rs7036319^1,2	C,	--	135600572(+)	`gatccA/Gcacgc`	1	--	int¹		0	--	--	--	--
rs189163247^1,2		--	135600577(+)	`ACACGC/TCTCGG`	1	--	int¹		0	--	--	--	--
rs7039533^1,2	C,F,A,	--	135600588(+)	`cctccC/Taaagt`	1	--	int¹		3		WA CSA	6
rs145523848^1,2		--	135600632(+)	`CCAAGA/GTGGGT`	1	--	int¹		0	--	--	--	--
rs7019609^1,2	C,F,A,H,	--	135600687(+)	`GCGCTA/GAGATC`	1	--	int¹		17		NS EA NA WA CSA	998
rs192025977^1,2		--	135600699(+)	`TCATCA/GGCATC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for AK8 (135600965 - 135754198 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AK8: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AK8 for disorders About GeneDecksing

1 disease for AK8: About MalaCards

adhd

Export disorders for AK8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for AK8 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with AK8)

Utopia: connect your pdf to the dynamic
world of online information

The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization a mong the family of adenylate kinase isoenzymes. (PubMed id 21080915)^{1, 2, 3} Panayiotou C....Karlsson A. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)¹ Trynka G....Wijmenga C. (2009)
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)¹ Lesch K.P....Jacob C. (2008)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)⁷ Imming P....Meyer A. (2006)
How many drug targets are there? (PubMed id 17139284)⁷ Overington J.P....Hopkins A.L. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)² Humphray S.J.... Dunham I. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 158067	HGNC: 26526	AceView: C9orf98	Ensembl:ENSG00000165695	euGenes: HUgn158067
ECgene: AK8	H-InvDB: AK8

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for AK8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for AK8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for AK8 gene:
Search GeneIP for patents involving AK8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	OriGene Antibodies for AK8		OriGene shRNA RFP for AK8
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AK8		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AK8
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	OriGene Custom Antibody Services for AK8		OriGene Custom Protein Services for AK8
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AK8
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AK8
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AK8
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AK8
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AK8
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	GenScript Custom Purified and Recombinant Proteins Services for AK8		GenScript cDNA clones with any tag delivered in your preferred vector for AK8
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	GenScript Custom overexpressing Cell Line Services for AK8		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AK8

	SwitchGear 3'UTR luciferase reporter plasmids for AK8
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ThermoFisher Antibodies for AK8

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AK8

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes AK8 gene at Home site.

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AK8 Gene

adenylate kinase 8

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AK8 Gene

adenylate kinase 8

Aliasesfor AK8 gene

Summariesfor AK8 gene

Genomic Viewsfor AK8 gene

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for AK8 gene

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for AK8 gene

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for AK8 gene

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for AK8 gene

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for AK8 gene

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for AK8 gene

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for AK8 gene

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for AK8 gene

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for AK8 gene

Expression
for AK8 gene

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for AK8 gene

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for AK8 gene

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for AK8 gene

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for AK8 gene

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for AK8 gene

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for AK8 gene

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for AK8 gene