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Aliases for AK7 Gene

Aliases for AK7 Gene

  • Adenylate Kinase 7 2 3 5
  • ATP-AMP Transphosphorylase 7 4
  • EC 2.7.4.3 4
  • EC 2.7.4.6 4
  • AK 7 4

External Ids for AK7 Gene

Previous GeneCards Identifiers for AK7 Gene

  • GC14P090675
  • GC14P094848
  • GC14P095928
  • GC14P096858
  • GC14P077043

Summaries for AK7 Gene

GeneCards Summary for AK7 Gene

AK7 (Adenylate Kinase 7) is a Protein Coding gene. Diseases associated with AK7 include reticular dysgenesis and primary ciliary dyskinesia. Among its related pathways are Metabolism and AMPK Enzyme Complex Pathway. GO annotations related to this gene include nucleoside diphosphate kinase activity and nucleobase-containing compound kinase activity.

UniProtKB/Swiss-Prot for AK7 Gene

  • Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AK7 Gene

Genomics for AK7 Gene

Regulatory Elements for AK7 Gene

Promoters for AK7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AK7 on UCSC Golden Path with GeneCards custom track

Genomic Location for AK7 Gene

Chromosome:
14
Start:
96,392,111 bp from pter
End:
96,489,427 bp from pter
Size:
97,317 bases
Orientation:
Plus strand

Genomic View for AK7 Gene

Genes around AK7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AK7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AK7 Gene

Proteins for AK7 Gene

  • Protein details for AK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M32-KAD7_HUMAN
    Recommended name:
    Adenylate kinase 7
    Protein Accession:
    Q96M32
    Secondary Accessions:
    • Q8IYP6

    Protein attributes for AK7 Gene

    Size:
    723 amino acids
    Molecular mass:
    82658 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AK7 Gene

Proteomics data for AK7 Gene at MOPED

Post-translational modifications for AK7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AK7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AK7 Gene

Domains & Families for AK7 Gene

Gene Families for AK7 Gene

Protein Domains for AK7 Gene

Suggested Antigen Peptide Sequences for AK7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96M32

UniProtKB/Swiss-Prot:

KAD7_HUMAN :
  • In the central section; belongs to the adenylate kinase family.
Family:
  • In the central section; belongs to the adenylate kinase family.
  • In the C-terminal section; belongs to the dpy-30 family.
genes like me logo Genes that share domains with AK7: view

Function for AK7 Gene

Molecular function for AK7 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.0 uM for AMP {ECO:0000269 PubMed:21080915}; KM=28 uM for dAMP {ECO:0000269 PubMed:21080915}; KM=1.2 uM for CMP {ECO:0000269 PubMed:21080915}; Vmax=1130 pmol/min/ug enzyme with AMP as substrate {ECO:0000269 PubMed:21080915}; Vmax=860 pmol/min/ug enzyme with dAMP as substrate {ECO:0000269 PubMed:21080915}; Vmax=150 pmol/min/ug enzyme with CMP as substrate {ECO:0000269 PubMed:21080915};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + AMP = 2 ADP.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function:
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function.

Enzyme Numbers (IUBMB) for AK7 Gene

Gene Ontology (GO) - Molecular Function for AK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004017 adenylate kinase activity IDA 21080915
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with AK7: view
genes like me logo Genes that share phenotypes with AK7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AK7

miRNA for AK7 Gene

miRTarBase miRNAs that target AK7

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AK7 Gene

Localization for AK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AK7 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AK7 Gene COMPARTMENTS Subcellular localization image for AK7 gene
Compartment Confidence
cytosol 5
nucleus 2
cytoskeleton 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for AK7 Gene

Pathways & Interactions for AK7 Gene

genes like me logo Genes that share pathways with AK7: view

Pathways by source for AK7 Gene

Interacting Proteins for AK7 Gene

Gene Ontology (GO) - Biological Process for AK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process IEA --
GO:0009142 nucleoside triphosphate biosynthetic process IDA 23416111
GO:0009165 nucleotide biosynthetic process EXP 10215863
GO:0016310 phosphorylation IEA --
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with AK7: view

No data available for SIGNOR curated interactions for AK7 Gene

Drugs & Compounds for AK7 Gene

(2) Drugs for AK7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for AK7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
Deoxyadenosine monophosphate
  • 2'-dAMP
  • 2'-Deoxy-5'-adenylate
  • 2'-Deoxy-5'-adenylic acid
  • 2'-Deoxy-Adenosine 5'-phosphorate
  • 2'-Deoxy-Adenosine 5'-phosphoric acid
653-63-4
genes like me logo Genes that share compounds with AK7: view

Transcripts for AK7 Gene

Unigene Clusters for AK7 Gene

Adenylate kinase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AK7 Gene

No ASD Table

Relevant External Links for AK7 Gene

GeneLoc Exon Structure for
AK7
ECgene alternative splicing isoforms for
AK7

Expression for AK7 Gene

mRNA expression in normal human tissues for AK7 Gene

Protein differential expression in normal tissues from HIPED for AK7 Gene

This gene is overexpressed in Testis (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AK7 Gene



SOURCE GeneReport for Unigene cluster for AK7 Gene Hs.667462

genes like me logo Genes that share expression patterns with AK7: view

Protein tissue co-expression partners for AK7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AK7 Gene

Orthologs for AK7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AK7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AK7 35
  • 99.17 (n)
  • 98.48 (a)
AK7 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AK7 36
  • 87 (a)
OneToOne
AK7 35
  • 86.65 (n)
  • 87.29 (a)
dog
(Canis familiaris)
Mammalia AK7 35
  • 87.26 (n)
  • 86.98 (a)
AK7 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ak7 36
  • 85 (a)
OneToOne
Ak7 16
Ak7 35
  • 82.65 (n)
  • 85.94 (a)
oppossum
(Monodelphis domestica)
Mammalia AK7 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AK7 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ak7 35
  • 82.68 (n)
  • 86.62 (a)
chicken
(Gallus gallus)
Aves AK7 36
  • 66 (a)
OneToOne
AK7 35
  • 69.85 (n)
  • 67.66 (a)
lizard
(Anolis carolinensis)
Reptilia AK7 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ak7-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ak7 35
  • 66.1 (n)
  • 64.01 (a)
Str.9896 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12827 35
zebrafish
(Danio rerio)
Actinopterygii ak7a 36
  • 50 (a)
OneToMany
ak7b 36
  • 52 (a)
OneToMany
ak7b 35
  • 58.82 (n)
  • 53.97 (a)
Dr.28379 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5754 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
Species with no ortholog for AK7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AK7 Gene

ENSEMBL:
Gene Tree for AK7 (if available)
TreeFam:
Gene Tree for AK7 (if available)

Paralogs for AK7 Gene

(1) SIMAP similar genes for AK7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with AK7: view

No data available for Paralogs for AK7 Gene

Variants for AK7 Gene

Sequence variations from dbSNP and Humsavar for AK7 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2275554 - 96,404,767(+) CTCTC(A/G)AGAAG reference, missense
rs2369679 - 96,456,415(+) GCCAA(C/G)TACTA reference, missense
rs1373097 -- 96,397,832(+) gtatc(C/T)ggaaa intron-variant
rs1890913 -- 96,417,632(+) CTTTG(C/T)TCTCT intron-variant
rs1443340 -- 96,395,488(+) aaacc(G/T)gtgtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AK7 Gene

Variant ID Type Subtype PubMed ID
nsv902211 CNV Loss 21882294
nsv510389 CNV Loss 20534489
esv2674373 CNV Deletion 23128226

Variation tolerance for AK7 Gene

Residual Variation Intolerance Score: 49.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.27; 85.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AK7 Gene

HapMap Linkage Disequilibrium report
AK7
Human Gene Mutation Database (HGMD)
AK7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AK7 Gene

Disorders for AK7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for AK7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
reticular dysgenesis
  • aleukocytosis
primary ciliary dyskinesia
  • kartagener syndrome
kartagener syndrome
  • kartagener's syndrome
- elite association - COSMIC cancer census association via MalaCards
Search AK7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AK7

Genetic Association Database (GAD)
AK7
Human Genome Epidemiology (HuGE) Navigator
AK7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AK7
genes like me logo Genes that share disorders with AK7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AK7 Gene

Publications for AK7 Gene

  1. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. (PMID: 23416111) Amiri M. … Solaroli N. (Int. J. Biochem. Cell Biol. 2013) 3 4 67
  2. New adenylate kinase 7 (AK7) mutation in primary ciliary dyskinesia. (PMID: 22801010) Mata M. … Cortijo J. (Am J Rhinol Allergy 2012) 3
  3. The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes. (PMID: 21080915) Panayiotou C. … Karlsson A. (Biochem. J. 2011) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Role of adenylate kinase type 7 expression on cilia motility: possible link in primary ciliary dyskinesia. (PMID: 20537283) Milara J. … Cortijo J. (Am J Rhinol Allergy 2010) 3

Products for AK7 Gene

Sources for AK7 Gene

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