AK7 Gene
protein-coding GIFtS: 53
GCID: GC14P096858
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adenylate kinase 7
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Aliases
for AK7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adenylate Kinase 71 2 | | FLJ328641 | | Putative Adenylate Kinase 72 | | EC 2.7.4.33 |
Export aliases for AK7 gene to outside databasesPrevious GC identifers: GC14P090675 GC14P094848 GC14P095928 GC14P077043 |
Summaries
for AK7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KAD7_HUMAN, Q96M32Function: Adenylate kinase involved in maintaining ciliary structure and function (By similarity). Has highest activitytoward AMP, and weaker activity toward dAMP, CMP and dCMP
|
Genomic Views
for AK7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AK7 gene promoter:
Oct-B1 GR oct-B3 oct-B2 FOXD3 HSF1 (long) FOXL1 HSF1short GR-alpha LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for AK7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AK7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.2 Ensembl cytogenetic band: 14q32.2 HGNC cytogenetic band: 14q32.31AK7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P096858: view genomic region
(about GC identifiers)
Start:
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96,858,448 bp from pter |
End:
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96,955,764 bp from pter |
Size:
|
97,317 bases |
Orientation:
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plus strand |
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Proteins
for AK7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KAD7_HUMAN, Q96M32 (See
protein sequence)Recommended Name: Adenylate kinase 7 Size: 723 amino acids; 82658 Da
Subcellular location: Cytoplasm, cytosol
Secondary accessions: Q8IYP6Explore the universe of human proteins at neXtProt for AK7: NX_Q96M32
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96M32
AK7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689540.2
ENSEMBL proteins: ENSP00000267584 ENSP00000451068 ENSP00000450453
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
IEA | -- |
AK7 for ontologies About GeneDecksing
AK7 Antibody Products:
Assay Products for AK7: |
Protein
Domains /
Families
for AK7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AK7 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96M32ProtoNet protein and cluster: Q96M32 2 Blocks protein families: IPB000850 Adenylate kinase IPB007858 Dpy-30
UniProtKB/Swiss-Prot: KAD7_HUMAN, Q96M32Similarity: In the central section; belongs to the adenylate kinase familySimilarity: In the C-terminal section; belongs to the dpy-30 family |
Function
for AK7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KAD7_HUMAN, Q96M32Function: Adenylate kinase involved in maintaining ciliary structure and function (By similarity). Has highest activitytoward AMP, and weaker activity toward dAMP, CMP and dCMPCatalytic activity: ATP + AMP = 2 ADPBiophysicochemical properties: Kinetic parameters: KM=1.0 uM for AMP; KM=28 uM for dAMP; KM=1.2 uM for CMP; Vmax=1130pmol/min/ug enzyme with AMP as substrate; Vmax=860 pmol/min/ug enzyme with dAMP as substrate; Vmax=150 pmol/min/ugenzyme with CMP as substrate;Enzyme Number (IUBMB): EC 2.7.4.31
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AK7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AK7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): AK7 (NM_020341) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AK7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AK7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AK7 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004017 | adenylate kinase activity |
IDA | -- | | GO:0004127 | cytidylate kinase activity |
IDA | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0019205 | nucleobase-containing compound kinase activity |
-- | -- |
AK7 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for AK7:
Animal Models:
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ak7):
AK7 for phenotypes About GeneDecksing
|
Pathways & Interactions
for AK7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | ATP/ITP metabolism | | | 2 | AMPK Enzyme Complex Pathway | | | 3 | Purine metabolism | | | 4 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | | | 5 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for AK7
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AK7
1  GeneGo (Thomson Reuters) Pathway for AK7
2 
Kegg Pathways (Kegg details for AK7):
AK7 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AK7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/48 Interacting proteins for AK7 (ENSP000002675844) via UniProtKB, MINT, STRING, and/or I2D (see all 48)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002437 | inflammatory response to antigenic stimulus |
IEA | -- | | GO:0003351 | epithelial cilium movement |
IEA | -- | | GO:0006139 | nucleobase-containing compound metabolic process |
-- | -- | | GO:0007283 | spermatogenesis |
IEA | -- | | GO:0007420 | brain development |
IEA | -- |
AK7 for ontologies About GeneDecksing
|
Drugs & Compounds
for AK7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AK7
5 HMDB Compounds for AK7 About this table
Search CenterWatch for drugs/clinical trials and news about AK7 / KAD7
|
Transcripts
for AK7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AK7 gene: NM_152327.3 Unigene Cluster for AK7: Adenylate kinase 7 Hs.667462 [show with all ESTs]Unigene Representative Sequence: NM_1523275 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000267584(uc001yfn.2) ENST00000555570(uc001yfm.1) ENST00000556643
ENST00000554313 ENST00000554706
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AK7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AK7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): AK7 (NM_020341) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AK7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AK7 |
Additional cDNA sequence: AK057426.1 BC023986.1 BC035256.1 5 DOTS entries: DT.100014700 DT.75137763 DT.75100746 DT.65285585 DT.100018557 24/36 AceView cDNA sequences (see all 36): BU622508 CA313867 BU607380 BU675343 AI792423 CA312368 BM981526 AI792424 BM018498 AI733700 AI761827 BX097430 BU944613 BM982686 AI739250 CA416623 AI191504 BU684495 AI733701 NM_152327 BC023986 AK057426 BG718413 BC035256
GeneLoc Exon Structure
|
Expression
for AK7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AK7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTGTTATC
About this image
See AK7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AK7
SOURCE GeneReport for Unigene cluster: Hs.667462
SABiosciences Custom PCR Arrays for AK7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AK7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AK7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AK7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AK7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AK7 |
Orthologs
for AK7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for AK7 gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for AK7 (if available)
TreeFam Gene Tree for AK7 (if available) |
Paralogs
for AK7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for AK7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AK7 (96858448 - 96955764 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AK7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AK7 |
|
Disorders
/ Diseases
for AK7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AK7 for disorders About GeneDecksing
4  diseases for AK7: About MalaCardsciliary dyskinesia reticular dysgenesis primary ciliary dyskinesia bronchiectasis
2 diseases from the University of Copenhagen DISEASES database for AK7:Primary ciliary dyskinesia Reticular dysgenesis Human Genome Epidemiology (HuGE) Navigator: AK7 (2 documents)
Export disorders for AK7 gene to outside databases
|
Publications
for AK7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AK7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with AK7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization a mong the family of adenylate kinase isoenzymes. (PubMed id 21080915)1, 2 Panayiotou C....Karlsson A. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
- New adenylate kinase 7 (AK7) mutation in primary cilia ry dyskinesia. (PubMed id 22801010)1 Mata M....Cortijo J. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Role of adenylate kinase type 7 expression on cilia m otility: possible link in primary ciliary dyskinesia. (PubMed id 20537283)1 Milara J....Cortijo J. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for AK7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AK7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AK7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AK7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AK7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for AK7 gene:
Search GeneIP for patents involving AK7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AK7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for AK7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AK7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AK7 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AK7 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AK7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AK7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AK7 | | OriGene Custom Protein Services for AK7 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AK7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AK7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AK7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AK7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AK7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AK7 |
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| | | | Search Tocris compounds for AK7 |
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 | | | AK7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AK7 |
|  |  |  | | | | ThermoFisher Antibodies for AK7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AK7 |
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