Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AK6 Gene

Aliases for AK6 Gene

  • Adenylate Kinase 6 2 3 5
  • Coilin Interacting Nuclear ATPase Protein 2 3
  • Adrenal Gland Protein AD-004 3 4
  • EC 2.7.4.3 4 63
  • HCINAP 3 4
  • CINAP 3 4
  • Coilin-Interacting Nuclear ATPase Protein 4
  • Dual Activity Adenylate Kinase/ATPase 4
  • ATP-AMP Transphosphorylase 6 3
  • Coilin Interacting Protein 3
  • AK/ATPase 4
  • CGI-137 3
  • AD-004 3
  • CIP 3

External Ids for AK6 Gene

Previous GeneCards Identifiers for AK6 Gene

  • GC00U990579
  • GC05M068647

Summaries for AK6 Gene

Entrez Gene Summary for AK6 Gene

  • This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for AK6 Gene

AK6 (Adenylate Kinase 6) is a Protein Coding gene. Among its related pathways are Purine metabolism and Chromatin organization. GO annotations related to this gene include ATPase activity and adenylate kinase activity.

UniProtKB/Swiss-Prot for AK6 Gene

  • Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AK6 Gene

Genomics for AK6 Gene

Regulatory Elements for AK6 Gene

Enhancers for AK6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AK6 on UCSC Golden Path with GeneCards custom track

Promoters for AK6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AK6 on UCSC Golden Path with GeneCards custom track

Genomic Location for AK6 Gene

Chromosome:
5
Start:
69,350,984 bp from pter
End:
69,370,013 bp from pter
Size:
19,030 bases
Orientation:
Minus strand

Genomic View for AK6 Gene

Genes around AK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AK6 Gene

Proteins for AK6 Gene

  • Protein details for AK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3D8-KAD6_HUMAN
    Recommended name:
    Adenylate kinase isoenzyme 6
    Protein Accession:
    Q9Y3D8
    Secondary Accessions:
    • A8MSZ6
    • Q5F2S9

    Protein attributes for AK6 Gene

    Size:
    172 amino acids
    Molecular mass:
    20061 Da
    Quaternary structure:
    • Monomer and homodimer (By similarity). Interacts with COIL (via C-terminus).

    Three dimensional structures from OCA and Proteopedia for AK6 Gene

    Alternative splice isoforms for AK6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AK6 Gene

Proteomics data for AK6 Gene at MOPED

Selected DME Specific Peptides for AK6 Gene

Post-translational modifications for AK6 Gene

Other Protein References for AK6 Gene

Domains & Families for AK6 Gene

Gene Families for AK6 Gene

Protein Domains for AK6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y3D8

UniProtKB/Swiss-Prot:

KAD6_HUMAN :
  • Belongs to the adenylate kinase family. AK6 subfamily.
Family:
  • Belongs to the adenylate kinase family. AK6 subfamily.
genes like me logo Genes that share domains with AK6: view

No data available for Suggested Antigen Peptide Sequences for AK6 Gene

Function for AK6 Gene

Molecular function for AK6 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=192 uM for AMP {ECO:0000269 PubMed:15630091, ECO:0000269 PubMed:16079131, ECO:0000269 PubMed:22038794}; KM=45 uM for ATP (for adenylate kinase activity) {ECO:0000269 PubMed:15630091, ECO:0000269 PubMed:16079131, ECO:0000269 PubMed:22038794}; KM=332 uM for ATP (for ATPase activity) {ECO:0000269 PubMed:15630091, ECO:0000269 PubMed:16079131, ECO:0000269 PubMed:22038794}; Vmax=1.27 umol/min/mg enzyme for ATPase activity {ECO:0000269 PubMed:15630091, ECO:0000269 PubMed:16079131, ECO:0000269 PubMed:22038794}; Vmax=982 nmol/min/mg enzyme for the forward adenylate kinase reaction {ECO:0000269 PubMed:15630091, ECO:0000269 PubMed:16079131, ECO:0000269 PubMed:22038794}; Vmax=955 nmol/min/mg enzyme for the reverse adenylate kinase reaction {ECO:0000269 PubMed:15630091, ECO:0000269 PubMed:16079131, ECO:0000269 PubMed:22038794}; Note=kcat is 6.3 sec(-1) for adenylate kinase activity. kcat is 4.8 sec(-1) for ATPase activity.;
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + AMP = 2 ADP.
UniProtKB/Swiss-Prot Function:
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.

Enzyme Numbers (IUBMB) for AK6 Gene

Gene Ontology (GO) - Molecular Function for AK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016887 ATPase activity IEA --
genes like me logo Genes that share ontologies with AK6: view

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AK6 Gene

Localization for AK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AK6 Gene

Nucleus, nucleoplasm. Nucleus, Cajal body. Note=Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.

Gene Ontology (GO) - Cellular Components for AK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with AK6: view

No data available for Subcellular locations from COMPARTMENTS for AK6 Gene

Pathways & Interactions for AK6 Gene

genes like me logo Genes that share pathways with AK6: view

Gene Ontology (GO) - Biological Process for AK6 Gene

None

No data available for SIGNOR curated interactions for AK6 Gene

Drugs & Compounds for AK6 Gene

No Compound Related Data Available

Transcripts for AK6 Gene

mRNA/cDNA for AK6 Gene

(2) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for AK6 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: -
SP9: - - - - - - -
SP10:

Relevant External Links for AK6 Gene

GeneLoc Exon Structure for
AK6
ECgene alternative splicing isoforms for
AK6

Expression for AK6 Gene

Protein differential expression in normal tissues from HIPED for AK6 Gene

This gene is overexpressed in Bone (23.4), Kidney (17.1), and Colon (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AK6 Gene



mRNA Expression by UniProt/SwissProt for AK6 Gene

Q9Y3D8-KAD6_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, chorionic villi and the central nervous system.

Protein tissue co-expression partners for AK6 Gene

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AK6 Gene

Orthologs for AK6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AK6 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ak6 35
  • 86.55 (n)
  • 88.3 (a)
Ak6 16
Taf9 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AK6 35
  • 100 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Ak6 35
  • 84.21 (n)
  • 86.55 (a)
cow
(Bos Taurus)
Mammalia TAF9 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF9 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves AK6 35
  • 75.24 (n)
  • 77.78 (a)
TAF9 36
  • 86 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia taf9 35
  • 74.07 (n)
  • 77.78 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:86811 35
  • 70.96 (n)
  • 75.44 (a)
taf9 36
  • 81 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000272 35
  • 50.68 (n)
  • 47.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ak6 35
  • 54.81 (n)
  • 47.85 (a)
e(y)1 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea E02H1.6 35
  • 57.14 (n)
  • 48.81 (a)
taf-9 36
  • 31 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL150W 35
  • 51.9 (n)
  • 46.11 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12386g 35
  • 54.49 (n)
  • 44.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAP7 35
  • 53.69 (n)
  • 41.32 (a)
TAF9 36
  • 29 (a)
OneToMany
FAP7 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G60340 35
  • 57.87 (n)
  • 55.83 (a)
rice
(Oryza sativa)
Liliopsida Os07g0412400 35
  • 57.06 (n)
  • 57.67 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10220 35
  • 54.51 (n)
  • 49.06 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC830.11c 35
  • 53.17 (n)
  • 44.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for AK6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AK6 Gene

ENSEMBL:
Gene Tree for AK6 (if available)
TreeFam:
Gene Tree for AK6 (if available)

Paralogs for AK6 Gene

(1) SIMAP similar genes for AK6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AK6: view

No data available for Paralogs for AK6 Gene

Variants for AK6 Gene

Sequence variations from dbSNP and Humsavar for AK6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs34525896 -- 69,356,411(+) GCCCA(-/G/GG)TACGA intron-variant
rs112728914 -- 69,353,944(+) TTTTA(-/T)TTTTT intron-variant

Variation tolerance for AK6 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for AK6 Gene

Disorders for AK6 Gene

Relevant External Links for AK6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AK6

No disorders were found for AK6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AK6 Gene

Publications for AK6 Gene

  1. Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus. (PMID: 16079131) Santama N. … Lamond A.I. (J. Biol. Chem. 2005) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies. (PMID: 22038794) Drakou C.E. … Zographos S.E. (Proteins 2012) 3
  4. hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14. (PMID: 23246961) Zhang J. … Zheng X. (Oncogene 2012) 3
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 3

Products for AK6 Gene

Sources for AK6 Gene

Content